title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Relative deficiency of plasma-calcitonin in normal women. | A new radioimmunoassay technique was used to measure plasma-calcitonin in normal subjects. Plasma-calcitonin concentrations in women were less than 25% of those in men, and were often undetectable. However, during pregnancy or administration of the oestrogen-progestagen contraceptive pill, plasma-calcitonin equalled or... | 76,891 | [
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Strong association between HLA-DRW2 and antibody-mediated Goodpasture's syndrome. | In a study of HLA types in Caucasian patients with nephritis due to antibodies to glomerular basement membrane, antigen frequencies at A, B, or CW loci were normal. However, 15 out of 17 (88%) patients to whom DRW types were definitely assigned had HLA-DRW2 compared with 32 out of 100 Caucasian blood-donors. This diffe... | 76,894 | [
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Primary hyperparathyroidism in paraneoplastic hypercalcaemia. | Hypercalcaemia is often associated with malignant disease. Causes of elevated serum-calcium levels in the absence of bony metastases include parathyroid-hormone production by the tumour, osteolytic factors made by the tumour, and coexistent primary hyperparathyroidism. By measuring nephrogenous cyclic-A.M.P. excretion ... | 76,931 | [
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Leucocyte adherence inhibition for detecting specific tumour immunity in early pancreatic cancer. | Tumour-specific immunity to pancreatic tumour antigens, assayed by an automated tube leucocyte-adherence inhibition assay (L.A.I.), was detected in 3 of 3 patients with localised pancreatic cancer and 3 of 8 patients with more extensive pancreatic cancer. Leucocytes from pancreatic cancer patients with L.A.I. reactivit... | 76,938 | [
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Intracellular calcium accumulation in Duchenne dystrophy and other myopathies: a study of 567,000 muscle fibers in 114 biopsies. | Ultrastructural studies have shown plasmalemmal defects in a proportion of non-necrotic muscle fibers in Duchenne dystrophy, suggesting that intracellular calcium overloading may be an important mechanism of muscle fiber degeneration. To investigate this assumption, we studied the localization of calcium with the von K... | 76,996 | [
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Enzymatic synthesis of DNA complementary to mitochondrial mRNA via reverse transcription. | The poly(A)-containing mitochondrial mRNAs of rat liver were tested for their ability to serve as templates for the DNA synthesis by means of reverse transcription in the presence of the oligo(dT) primer and the RNA-directed DNA-polymerase from avian myeloblastosis virus. The mT-mRNA does not support the DNA synthesis ... | 77,007 | [
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Regulation of rat alpha-fetoprotein production by methionine and adenosine 5'-triphosphate. | Simultaneous and equimolar injections of methionine and adenosine 5'-triphosphate significantly accelerated the rapid fall of rat serum alpha-fetoprotein (AFP) concentrations after birth. The results were compared with those obtained by administrations of prednisolone and adult tissue extracts. Correlations between a m... | 77,035 | [
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Primary affective disorders and HLA antigens. | In 125 patients with various types of primary affective disorders, 27 HLA antigens of the A, B and C loci were examined. Bw40 occurred more frequently in the primarly form (20.83% against 7.64% in controls) and Cw4 in the unipolar form (25%) and, in disease in general, 16%, against 9.58% in controls. Following correcti... | 77,064 | [
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[Virion precipitation reaction based on determination of reverse transcriptase activity: Method of study of membrane antigens of oncornaviruses]. | A method for the study of the envelope antigens of oncornaviruses of C, B, and D types by the virion precipitation test (VPT) based on the measurement of the amount of precipitated virus by its reverse transcriptase activity is described. The method is immunologically specific for titration of antibody to the envelope ... | 77,082 | [
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[Treatment of burned children--current therapeutic principles (author's transl)]. | This paper deals with the working plan of immediate care, parenteral nutrition and surgery in burned children according to experience gained in the treatment of these children at the specialist Burns Unit of the Department of Dermatology (I) of the University of Vienna. Features peculiar to this age group lie in the ap... | 77,086 | [
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A receptor-immunoassay for the determination of the specificity of anti-HCG-beta sera. | In the receptor-immunoassay, the binding of anti-HCG-beta sera to 125I-HCG and 125I-HLH is measured in the presence of bovine corpus luteum "receptor". Anti-sera specific for HCG show little binding with 125I-HLH. The receptor-immunoassay permits an evaluation of specificity, affinity and the ability of anti-HCG-beta s... | 77,119 | [
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The role of the anaesthetist in chronic pain management. | The role of the anaesthetist in the continuing care of patients suffering from chronic pain has been discussed. Many of the techniques, both invasive and non-invasive, which are currently available for the treatment of chronic pain have been reviewed. | 77,139 | [
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[Method of intravital injection of the internal blood vessels of organs for experimental-morphological research]. | Ten minutes before the injection the rat is given heparin (500 units per 1 kg weight) intradermally. To the narcotized animal, the needle with the 1 ml syringe is inserted and 3--5 ml of blood are aspirated (about 2% of the body mass). Then with the same needle another syringe of 10 ml volume containing filtrated and h... | 77,152 | [
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Cellular histamine release, specific and total serum IgE levels in hay fever patients and controls. | The amount of histamine released from blood leucocytes by allergen, the amount of allergen required to release 50% histamine and the total IgE and IgE specific for Dactylis glomerata are compared in nine hay fever patients and five control individuals. The variation with time of total IgE, of specific IgEe and of the p... | 77,195 | [
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Aneuploidy and ageing: chromosome studies on a random sample of the population using G-banding. | Chromosome analysis using G-banding was carried out on cells from 65 males and 102 females of all ages from a random sample of the population. The frequency of aneuploid cells showed a significant increase with age in both sexes, and in females the increase in hypodiploidy and hyperdiploidy was more marked than in male... | 77,211 | [
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Human tumor and rodent-human hybrid cells with an increased number of active human NORs. | A human fibrosarcoma line, HT1080-6TG, with a near diploid number of chromosomes, has an average of 7.3 chromosomes with an Ag-stained nucleolus organizer region (NOR). Cells of this line with an increased number of chromosomes have an increased number of Ag-stained NORs. This cell line has been used as the human paren... | 77,212 | [
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Serum and tumour ferritins in primary liver cancer. | Serum ferritin concentrations were found to be raised, often considerably, in 58 of 76 black patients with primary liver cancer (PLC). No correlation could be demonstrated between the serum ferritin concentration and several other measurements, including the following: hepatic iron stores measured chemically, the size ... | 77,242 | [
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The capping of lymphocytes and other cells, studied by an improved method for immunofluorescence staining of frozen sections. | Experiments have been carried out on the capping by lectins and antibodies of surface receptors of mouse splenic T and B lymphocytes and other cells, in which the surface distribution of the lectin or antibody, and the intracellular distribution of myosin or actin, were determined on the same cells by a double fluoresc... | 77,276 | [
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Radioimmunoassay of ovine alpha-fetoprotein. | Highly purified ovine alpha-fetoprotein (AFP) was used both for radioisotope labelling and as the reference standard in the double antibody radioimmunoassay of ovine AFP. The sensitivity of the assay is 2 ng/ml which is about 8000 times more sensitive than radialimmunodiffusion assay. The assay is of sufficient sensiti... | 77,294 | [
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Anterior-horn cell degeneration and gross calf hypertrophy with adolescent onset. A new spinal muscular atrophy syndrome. | A new variant of spinal muscular atrophy (S.M.A.), characterised by adolescent onset, gross hypertrophy of calves, and a slowly progressive clinical course, was found in 5 patients, 3 of them in a series of 102 cases being studied in North-East England. Biopsy and electrophysiological studies indicated the presence of ... | 77,364 | [
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Drug-induced immunological neutropenia. | Antineutrophil antibody capable of opsonising normal neutrophils was detected in the sera of 16 neutropenic patients receiving various drugs. A single drug was involved in 10 cases, multiple medication in 6. 4 patients received semisynthetic penicillins, 8 some form of antimicrobial, and 2 antithyroid agents. Neutrophi... | 77,368 | [
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[Distribution studies of 111In labeled bleomycin in the intratumoral and peritumoral treatment of advanced squamous cell carcinomas in the oto-rhino-larygnological region (author's transl)]. | The localization of 111In labeled Bleomycin was studied in 9 patients with advanced squamous cell carcinomas. The dosis was injected either peritumorally or intramorally. Accumulation of Radiobleomycin in tumor tissue, in blood and in urine was tested. We found a very high accumulation in tumor tissue for a short time ... | 77,462 | [
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Ethanol-induced alterations in histamine content and release in the rat hypothalamus. | In the rat hypothalamus, histamine content and histidine decarboxylas: activity are enhanced significantly after acute administration (80--160 mg/100g body weight) of ethanol. The effects are less pronounced after chronic treatment (15% v/v in drinking water for 4 weeks). Histamine methyltransferase is unaffected in ei... | 77,479 | [
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Specificity of Fc-receptors on lymphocytes and monocytes for guinea-pig IgG1 and IgG2: phagocytosis of erythrocytes. | The capacity of guinea-pig IgG1 and IgG2 antibodies to induce lymphocyte (K-cell) mediated lysis or monocyte/macrophage mediated phagocytosis of erythrocytes was studied with both human and guinea-pig effector cells. For both species, induction of K-cell mediated lysis was restricted to IgG2 whereas both IgG1 and IgG2 ... | 77,554 | [
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[Evaluation of the antigenicity of heart valve leaflets using inbred rat strain combinations (author's transl)]. | Experiments with large, non-inbred animals yield no reliable evidence in the antigenicity of heart valves. With inbred strains of rats, however, it is possible to obtain evidence on the immunological reactions of heart valve leaflet transplants. Our experiments were undertaken on the inbred rat strains (CDR, LEW, CAP a... | 77,566 | [
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[Change in the brain neuron structure of man and other mammals in edema and swelling of the brain substance]. | A correlation was made between literature and obtained light microscopy data relative to the problem concerning the central neuron involvement at edema development and brain tissue swelling at different etiological backgrounds. A polymorphism of neuronic variations was demonstrated determined by a variety of causes inc... | 77,577 | [
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[The manual extrathoracal stimulation of the heart. Technique and effect of the precordial thump (author's transl)]. | The findings of the manual extrathoracal stimulation of the heart (precordial thump) among 50 persons, healthy individuals and patients with pacemakers, are reported. By all persons it was possible either to cause "extrasystoles" through single blows or to maintain a continuous heart action through a rhythmic stimulati... | 77,593 | [
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[Incidence of a persisting prostatic duct following transvesical adenomectomy]. | 32 patients underwent an after-examination one to five years after transvesical adenomectomy. In 25 cases thare was a persisting lodge of the prostate. 6 patients with persisting lodge had urethrographically a narrowing in the region of the posterior urethra. There were no pathological values of the residual urine and ... | 77,601 | [
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0.1033456,
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0.272224,
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0.002152239,
0.2332506,
-0.2185046,
0.2982189,
0.1221572,
0.2262316,
-0.046... |
[Early catheter removal in water-tight bladder closure following transversical prostatic adenometomy]. | It is reported on 124 patients in whom after a transvesical adenomectomy an early removal of the catheter was aspired to. A watertight closure of the urinary bladder is one of the most important prerequisites. The 5th day after operation seems to be best suited for the removal of the catheter. A temporary fistulisation... | 77,602 | [
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0.0011456... |
Primary culture of adult rat liver cells. II. Cytological and biochemical properties of primary cultured cells. | Primary mass culture of isolated cells from adult rat livers by the trypsin-perfusion method uas carried out to investigate cytological and biochemical properties of primary cultured cells. Two main types of cells were found in the course of primary culture of isolated hepatic cells. One was a group of polygonal cells ... | 77,631 | [
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... |
African trials in chemotherapy of gastrointestinal cancer. | Bleomycin either alone or in combination with radiotherapy was used in the treatment of 24 patients with non-resectable cancer of the oesophagus. Improvement in performance (swallowing) status was observed in 75% of patients, although only 19% were known to be alive after 1 year of follow-up. Patients with liver cancer... | 77,658 | [
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0.09631852,
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Induction of four proteins in eukaryotic cells by kethoxal bis(thiosemicarbazone). | Kethoxal bis(thiosemicarbazone) induces the synthesis of four proteins (100 000, 70 000, 35 000 and 25 000 daltons) in normal chick embryo cells. The 70 000 dalton species is produced at the fastest rate 2 hr after exposure to the compound. Pulse-chase experiments revealed neither precursors nor products of these prote... | 77,683 | [
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... |
A rapid assay for neuraminidase. The detection of two differences in activity associated with virus transformation. | Neuraminidase (acylneuraminyl hydrolase, EC 3.2.1.18) activity in fibroblast homogenates was measured by a rapid and simple assay with a synthetic substrate. The activity of neuraminidase in virus transformed hamster fibroblasts was increased over the normal counterpart. In addition, the differential activity seen usin... | 77,684 | [
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Antenatal prophylaxis of Rh isoimmunization: 28-weeks'-gestation service program. | Two (0.18%) of 1086 Rh-negative primigravidas or multigravidas treated similarly in all previous pregnancies, who were given a single injection of Rh immune globulin (300 mug) at 28 weeks' gestation and subsequently were delivered of Rh-positive babies, had demonstrable Rh isoimmunization at the time of that injection ... | 77,715 | [
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0.113658... |
Treatment of advanced Hodgkin's disease with adriamycin, bleomycin, vinblastine, and imidazole carboxamide (ABVD) after failure of MOPP therapy. | From June 19, 1975 to December 22, 1976, twenty-seven patients with advanced Hodgkin's disease who failed MOPP (nitrogen mustard, vincristine, procarbazine and prednisone) were treated with adriamycin, bleomycin, vinblastine, and imidazole carboxamide, (ABVD). Complete response (CR) was achieved in 22% of patients and ... | 77,716 | [
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Comparative antitumor activity of actinomycin analogs in mice bearing Ridgway osteogenic sarcoma or P388 leukemia. | Actinomycin (Act) analogs, differing in the chemical substitution(s) made at various positions in either their pentapeptide chain(s) or chromophore ring, were evaluated for their antitumor activity in mice bearing either Ridgway osteogenic sarcoma (ROS) or P388 leukemia. Of the analogs tested against advanced (2--3-g) ... | 77,730 | [
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Placental-like alkaline phosphatase in malignant and benign ovarian tumors. | Alkaline phosphatase (ALP) components in extracts of seven malignant and eleven benign ovarian tumors were characterized using the criteria of electrophoretic mobility before and after neuraminidase treatment, heat stability, L-phenylalanine inhibition and reactivity against antiplacental ALP antiserum. Seven of the ei... | 77,747 | [
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Factors involved in differential Giemsa-staining of sister chromatids. | Microspectrophotometric evaluation of differentially stained sister chromatids made it possible to analyse precisely the factors involved in the Giemsa methods. The concentration of Hoechst 33258, pH of the mounting medium temperature during UV-exposure and the quality (wavelength)of UV-light influenced the differentia... | 77,756 | [
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Wrist actigraphic measures of sleep and rhythms. | With a piezo-electric activity transducer, wrist activity recordings were made simultaneously with EEG, EOG and EMG recordings. Wrist activity alone was used to estimate Total Sleep Time and blind independent scoring of sleep and wakefulness by EEG-EOG-EMG was done. Correlations between the two methods were termined fo... | 77,772 | [
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0.07628429... |
A phase locked loop device for automatic detection of sleep spindles and stage 2. | A method is described using phase-locked loops which, as electronic frequency detection devices, provide the basis of a relatively inexpensive system of automatic sleep spindle detection. It is acceptably reliable at quite high rates of data processing. | 77,773 | [
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Regulation of the immune response. I. Regulatory cell equilibrium in the "virgin" state. | Spleen cells from pairs of inbred mice (age- and sex-matched) were challenged in vitro with a T-independent antigen. The specific plaque-forming cell (PFC) response in cultures containing cells from both donors was not intermediate to the responses of independently cultured donor spleen cells. Instead, a pattern of sig... | 77,784 | [
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0.2301206,
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[The postnatal development of lamina V pyramidal cells in the sensomotor cortex of the albino rat. 1. Introduction and qualitative studies of Golgi preparations]. | 1. It is given an introductory survey about the usual Golgi procedures and modifications, and about the possible quantitative methods in Golgi researches. Upon them a synopsis of the literature about dendrite spine distribution and density in rodents' cortices (mouse, rat, hamster) follows. Concluding the preamble it i... | 77,800 | [
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Target cell - substratum interaction. I. Effect of primed lymphocytes on a rat mammary adenocarcinoma tumor cell line. | The differential effects of normal and immunologically primed lymphocytes on the adherence of trypsinized rat mammary adenocarcinoma tumor cells (DMBA"8) to their substratum are described, utilizing both allogeneically and syngeneically primed lymphoid cells as effectors. This observation may illustrate an important im... | 77,840 | [
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Degradation products of fibrinogen by elastase-like neutral protease from human granulocytes. Characterization and effects on blood coagulation in vitro. | We investigated the effect of elastase-like neutral protease isolated from human granolocytes on human fibrinogen. Dependent on enzyme concentration and time of incubation, the elastase-like protease induced a progressive degradation of fibrinogen. Analysis of the remaining polypeptide chains showed a high susceptibili... | 77,863 | [
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Idiotype-specific transplantation resistance to MOPC-315: abrogation by post-immunization thymectomy. | The idiotype-specific myeloma transplantation resistance induced in BALB/c mice by immunization with the DNP-binding IgAlambda2 protein produced by plasmacytoma MOPC-315 is ablated by post-immunization thymectomy. Sham-thymectomy has no effect. The ablative effect of thymectomy is observed is observed in mice challenge... | 77,876 | [
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... |
Concealed atrial bigeminy and trigeminy. | Patterns indicative of concealed atrial extrasystoles were observed in two patients with frequent premature atrial depolarizations. In the first patient, the predominant pattern was such that most of the numbers (S) of sinus P waves between atrial extrasystoles satisfied the equation S = 3n-1, where n is any positive i... | 77,889 | [
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0.02391428... |
The role of the radioimmunoassay of serum alpha-fetoprotein and human chorionic gonadotropin in the intensive chemotherapy and surgery of metastatic testicular tumors. | Quantitative measurement of serum alpha-fetoprotein and human chorionic gonadotropin by double antibody radioimmunoassays reflects the efficacy of surgical, radiation and/or chemotherapeutic regimens in patients with bulky disseminated testicular tumors. When these therapies are effective they produce an immediate decr... | 77,918 | [
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The effect of human serum on 3H-thymidine incorporation in human prostate tumors in tissue culture. | Human prostatic tumors, 4 adenomas and 4 adenocarcinomas, were established in tissue culture. We used the incorporation of 3H-thymidine into deoxyribonucleic acid as a measure of cell activity to compare the effects of supplementing the culture media with human or fetal calf serum. 3H-thymidine incorporation was greate... | 77,919 | [
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... |
Scintigraphic detection of atherosclerotic lesions and venous thrombi in man by indium-111-labelled autologous platelets. | Accumulation of autologous platelets labelled with indium-111 at sites of atherosclerosis or venous thrombosis was demonstrated by scintigraphy in three patients. The lesions detected were bilateral ulcerated carotid-artery plaques, iliofemoral venous thrombosis, and renal-vein thrombosis. This technique shows promose ... | 77,949 | [
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... |
Weight-for-age as an index of risk of death in children. | Between April, 1968, and May, 1973, the Department of International Health of Johns Hopkins University studied the effects of the interaction of nutrition and infection in fourteen villages of Punjab, North India. Serial anthropometric measurements (used as index of nutritional status) and vital statistics of almost 30... | 78,007 | [
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0.132319,
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0... |
Avoidance of anencephalic and spina bifida births by maternal serum-alphafetoprotein screening. | Screening of 11 585 pregnant women between 16 and 20 completed weeks' gestation for raised serum-alphafetoprotein (A.F.P.) levels showed that the birth of 81.4% of babies with open neural-tube defects could be avoided. The screening test was sensitive enough to detect 93% of those affected and serum-A.F.P. levels above... | 78,097 | [
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... |
Inhibition of active-transport sodium-potassium-A.T.P.ase by myeloma protein. | Patients with multiple myeloma excrete immunoglobulin light chain (Bence-Jones protein) in the urine. Light chain accumulates in the nephron, and this may result in renal disease, which accounts for the death of between 1 in 4 and 1 in 7 patients with multiple myeloma. Myeloma light chain inhibits transport of paraamin... | 78,213 | [
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0.2421561,
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... |
Leucocyte adherence inhibition test in arthritis. | Peripheral leucocytes from healthy blood-donors were preincubated in polyarthritic serum or normal serum and their adherence to glass tubes in the presence of synovial extract of control extract was measured. Serum from patients with inflammatory polyarthritis significantly reduced the proportion of leucocytes which ad... | 78,294 | [
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0.01586438,
-0.1903502... |
Substances moved by axonal transport and released by nerve stimulation have an innervation-like effect on muscle. | Substances which have an innervation-like effect on the cholinesterase activity of organ-cultured rat extensor digitorum longus muscles are moved in nerve by axonal transport, are released from nerve by stimulation, and are present in innervated muscle but apparently absent from denervated muscle. Substances which incr... | 78,522 | [
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0.1371245,
0.02929948,
0.1672316,
0.07920296... |
Suppression of chronic allergic encephalomyelitis: relevance to multiple sclerosis. | The expression of chronic relapsing experimental allergic encephalomyelitis in strain 13 guinea pigs was suppressed with a single series of injections of myelin basic protein in incomplete Freund's adjuvant. The suppression appeared permanent, and subsequent rechallenge with central nervous system antigen failed to eli... | 78,524 | [
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0.2298183,
-0.03009... |
[Use of chlormadinone acetate (CAP) in bovine reproduction (author's transl)]. | The results obtained with chlormadinone acetate (CAP) in the treatment of dairy cattle with inactive ovaries (anoestrus) and during the puerperium are reported. CAP was administered to eighteen animals with inactive ovaries for fourteen days. Oestrus occurred in fourteen animals within from one to four days after treat... | 78,531 | [
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... |
Relationship of HLA--D associated B lymphocyte (Ia-like) antigens in the cell membrane. | The molecular relationship of HLA--D-associated by B lymphocyte antigens was studied in lysostrip, immunofluorescence and MLC inhibition experiments. Two B cell antigens, strongly associated with HLA--Dw2 and Dw3 respectively, redistributed independently of each other in the cell membrane. A more broadly reacting B cel... | 78,538 | [
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[Drug therapy of thyroid malignomas (author's transl)]. | We may recapitulate: Chemotherapy, first of all with adriamycin, has proved successful in thyroid cancer even after exhaustion of the therapeutic measures used so far. The combination of adriamycin with bleomycin and Velbe, corresponding to our preliminary experiences, seems to be superior to a monotherapy with adriamy... | 78,550 | [
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[Therapeutic effect of myelin basic protein and synthetic encephalitogenic peptide in guinea pigs with experimental allergic encephalomyelitis]. | Effect of antigenic factors of experimental allergic encephalomyelitis (alkaline protein of myelin and synthetic encephalitogenic peptide) was studied in guinea pigs with distinct manifestations of the experimental allergic encephalomyelitis. The animals recovered after prolonged administration of alkaline protein of m... | 78,577 | [
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Nomenclature for factors of the HLA system--1977. | A Nomenclature Committee composed of geneticists and immunologists, including specialists in tissue typing, has met after each of the Histocompatibility Testing Workshops beginning with the 3rd Workshop in 1967. The Committee met again, in part under the auspices of the World Health Organisation and for report to the I... | 78,582 | [
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Immunoglobulin-bearing cells in leprosy. | Peripheral blood lymphocytes of 28 untreated and 17 treated patients with different types of leprosy were investigated for the occurrence of immunoglobulin (Ig) bearing cells by means of a smear method. Seven healthy Africans served as controls. In a later stage a complementary study was performed on 6 tuberculoid and ... | 78,615 | [
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Antenatal assessment of fetal age and maturity using fetal fat staining cells in amniotic fluid. | A cross sectional retrospective study of 400 cases of amniocentesis was performed to evaluate the reliability of using fetal fat staining cells as a method for assessment of fetal age and maturity. A sharp rise in the percentage of these cells in amniotic fluid occurred after 37 weeks of gestation and a level of 20 per... | 78,612 | [
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0.005... |
Recurrent bullous eruptions on the lower legs. | In 15 patients with venous or arterial insufficiency of the legs, bullous eruptions were observed on the lower legs. The bullae were subepidermally situated. Circulating antibodies against the basement membrane zone were not demonstrated in 2 cases investigated. This eruption seems to represent a clinical entity of unk... | 78,629 | [
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Lymphocyte transformation induced by nickel sulphate: an in vitro study of subjects with and without a positive nickel patch test. | Lymphocytes from 8 patients with contact dermatitis and a positive nickel patch test, 7 patients with contact dermatitis due to other factors and with a negative nickel patch test, and 9 other subjects, 7 of whom suffered from other dermatological disorders, were tested with the lymphocyte transformation test (LTT), us... | 78,640 | [
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5-S-cysteinyldopa and trichochromes in red feathers. | Red cock feathers (Rhode Island) were found to contain dopa and cysteinyldopa, trichochromes B and C, and two unidentified trichochromes. Trichochromes E and F were not found. Previous findings of trichochromes E and F may be explained as artifacts. | 78,644 | [
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The effect of sodium 5,6-dimethyl-2-nitroindanedione on anaphylactic reactions in vitro. | A nitroindanedione (BRL 10833) inhibited the antigen induced release of histamine and slow reacting substance of anaphylaxis (SRS-A) from passively sensitized human lung at similar concentrations to those required for the inhibition of histamine release by disodium cromoglycate (DSCG). BRL 10833 was more potent than DS... | 78,665 | [
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Analytical methodology for the determination of Kepone residues in fish, shellfish, and Hi-Vol air filters. | The recent discovery of the pollution of the environment with Kepone has resulted in a tremendous interest in the development of residue methodology for the compound. Current multiresidue methods for the determination of the common organochlorinated pesticides do not yield good quantitative analytical results for Kepon... | 78,687 | [
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[Morphology and morphophysiology of reactive neuronal states]. | It is stated that nonspecific reactivity of the neuron to the irritating action of an agent is based on some morphological regularity such as dynamics of its structural-tinctorial changes. There exists a definite parallelism between phase development of the dynamics and fluctuations of the membrane potential (MP): inva... | 78,701 | [
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A catalytic role for heparin. Evidence for a ternary complex of heparin cofactor thrombin and heparin. | The interaction of heparin with chemically modified thrombin and heparin cofactor is studied. Amidinated heparin cofactor does not bind to heparin-agarose and the reaction rate of the amidinated inhibitor with unmodified thrombin is not affected by heparin. Likewise, thrombin modified with 1,2--cyclohexanedione does no... | 78,728 | [
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Elimination of asialofetuin and asialoorosomucoid by the intact rat. Quantitative aspects of the hepatic clearance mechanism. | The capacity of the liver to eliminate asialofetuin and asialoorosomucoid was investigated in intact rats. From plasma radioactivity curve measurements and assays on tissue homogenates the liver is shown to be able to dispose of an average of 19.8 microgram of asialofetuin/min per 100 g body weight. No other major rout... | 78,729 | [
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A case of slow variant bisalbuminmia: study of its composition in amino acids. | The authors report an observation of slow variant bisalbuminemia. After electrophoretic separation of two varieties, the amino acid chromatographic analysis has permitted them to show that in the slow variant the molecule of albumin has undergone a substitution of several glutamic acid residues by lysine and of several... | 78,734 | [
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[Detection of antigenic determinants of membranes using an insoluble peanut lectin]. | The binding of lectins on insoluble supports may be used to detect the interactions occurring between these molecules and the sites of some receptors of membranes. An example is given, using the "anti-T" lectin extracted from peanut, to show the presence of determinants with terminal free glactose on the surface of ery... | 78,776 | [
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Auditory brain stem potentials in monkey (M. mulatta) and man. | Auditory brain stem potentials were mapped over the head of the rhesus monkey following monaural clicks. Latency and amplitude were dependent upon the recording site. No electrically indifferent point could be found on the head or neck. The results are interpreted as showing that waves I and V originate from single gen... | 78,822 | [
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Occipital rhythmic activity within the alpha band during conditioned externally paced movement. | The time-dependent behaviour of the power within the alpha band during conditioned movement was studied from the scalp EEG of 9 normal humans. Two tasks were used: (1) button pressing at imperative signal S1 and release at signal S2; (2) button pressing at imperative signal S2, preceded by warning signal S1. Together w... | 78,832 | [
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0.539491,
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0.00271612... |
Quantitative determination of single serum proteins during acute hepatitis in childhood. | Fifteen serum proteins were estimated by linear immunodiffusion in blood samples from children with acute hepatitis. Blood was drawn at the beginning of the disease and three weeks later. The results were compared with results obtained from a group of age-matched normal children. At the beginning of the disease prealbu... | 78,848 | [
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Purification and partial characterization of hepatitis e antigen (HBeAg). | Purification of hepatitis e antigen (HBeAg) from 200 ml of chimpanzee plasma was accomplished by a combination of ion-exchange chromatography on diethylaminoethyl-cellulose followed by gel filtration. High-resolution sodium dodecyl sulfate-polyacrylamide gel electrophoresis of purified HBeAg demonstrated two major poly... | 78,902 | [
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Electron-microscopic study of the anaphylactic degranulation of human basophils from atopic subjects. | Leukocytes from subjects allergic to Dermatophagoides pteronyssinus were incubated for 20 min with a solution of D. pteronyssinus extracts. Histamine release was measured at 0, 3, 10 and 20 min. Simultaneously, samples were treated for electron microscopy in such a way as to correlate histamine release and the morpholo... | 78,905 | [
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Saccharide distribution in human trophoblast demonstrated using fluorescein-labelled lectins. | The reaction of six Flourescein-conjugated lectins with human trophoblast and foetal limb are described. The trophoblast had marked membrane fluorescence after treatment with wheatgerm and Lotus tetragonolobus lectins. Concanavalin A reacted strongly with the trophoblastic cytoplasm but did not react with the nuclei. M... | 78,921 | [
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Comparison of immunofluorescence and immunoperoxidase staining for identification of rubella virus isolates. | To explore possible advantages which immunoperoxidase (IP) staining might have over immunofluorescence (IF) staining for identifying rubella virus isolates, direct comparative studies were done on the same coded clinical materials using the same rubella immune rabbit serum as the primary antiserum in both systems. The ... | 78,928 | [
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Ontogeny of actin and microsomal antigens in gastric parietal cells. | Six fetal and 10 neonatal rat or mouse stomachs and a 14-week human fetal stomach were examined for immunofluorescence reactivity with four sera containing parietal cell antibody (PCA) and four other sera containing smooth muscle antibody (SMA). In rat and mouse stomachs, parietal cells first reacted with PCA in 19-day... | 78,930 | [
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Technical improvements in the mixed antiglobulin rosetting reaction with consequent demonstration of high numbers of immunoglobulin-bearing lymphocytes in viable preparations of human peripheral blood. | A modification of the mixed antiglobulin rosetting reaction (MARR) to improve sensitivity as a test for immunoglobulin (Ig)-bearing human blood lymphocytes is described. A mean 5.7%, lymphocytes Ig-positive by the MARR when rosettes were formed in medium containing 0.2% bovine serum albumin (BSA), increased to 20% when... | 78,951 | [
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Group-specific component [Gc] levels in chronic liver disease. | Serum Group-specific component (a probable vitamin D transport protein) concentrations have been measured in 72 patients with chronic liver disease. Low mean values were found in groups of patients with cirrhosis and metastatic liver disease. In a group of patients with biliary tract disease the mean value was not sign... | 78,953 | [
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0.2734444,
-0.1188192... |
Immunological studies of T-cell receptors. I. Specifically induced resistance to graft-versus-host disease in rats mediated by host T-cell immunity to alloreactive parental T cells. | The present studies extend our previous efforts to understand the immunological basis of specifically induced graft-versus-host (GVH) resistance in F1 hybrid rats. Immunization of F1 rats with alloreactive T-cell populations of parental strain origin induces a host-mediated T-cell response which is specific for anti-ma... | 78,954 | [
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0.1094968,
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-0.5069088,
-0.3721744,
-0.2168218,
0.04389903,
0.1532834,
0.260077,
0.2256064,
0.2933743,
-0.05959588,
... |
Increased arterial-tissue cholesterol after intestinal bypass in severe obesity. | Cholesterol content was measured in biopsy specimens of mesenteric artery taken at the time of jejuno-ileal bypass from 4 very obese patients aged 19, 22, 27, and 42. When their body-weight had become stable (mean 22 months) after operation, biopsy specimens of the temporal artery were obtained from 3 patients and of a... | 79,083 | [
0.2844282,
-0.08998892,
-0.39661,
-0.09498504,
0.214382,
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0.180079,
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0.3652728,
0.2141855,
0.2369444,
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-0.02670849,
0.0004078646,
0.4937344,
0.1599903,
0.2595336,
-0.1856702,
... |
Localization of human pancreatic polypeptide in an argyrophilic fourth cell type in islets of the rat pancreas. | An argyrophilic fourth cell type in the rat pancreatic islet can be differentiated from other silver-staining cells by using a modification of the Grimelius aqueous silver nitrate technique. Restaining of the tissues using fluorescent techniques with anti-HPP (Human Pancreatic Polypeptide) serum results in bright fluor... | 79,309 | [
0.06706569,
-0.2459919,
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0.1099797,
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0.2909588,
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0.5594622,
0.2399732,
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0.04095101,
0.2166243,
-0.1851845,
0.0113895,
0.1871651,
0.1045454,
... |
Soft lens therapy for recurrent erosion syndrome. | Thirty-three eyes of 25 patients with previously unrelieved recurrent erosion syndrome were treated with soft contact lenses. Marked improvement was obtained in 16 cases, moderate in 6, and 11 patients showed no improvement. Patients with visible anterior membrane dystrophies and spontaneous recurrent erosion syndrome ... | 79,322 | [
-0.1330056,
0.2379221,
0.2789611,
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0.3351786,
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0.2325164,
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0.01388051,
0.03285214,
0.0144723,
-0.002992939,
0.04395902,
-0.1405... |
Seasonal changes in serum free fatty acid level in the migratory Canada goose. | The changes in the serum level of free fatty acids (FFA) in the migratory Canada goose (Branta canadensis interior) breeding in Ft. Churchill (Manitoba, Canada) and wintering in Swan Lake (Missouri, U.S.A.), were studied during the different periods of its yearly life cycle. The lowest serum FFA level was noted during ... | 79,367 | [
-0.2140327,
0.05918377,
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0.1370272,
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0.1240324,
0.1715154,
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0.4027188,
-0.2066991,
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0.3367193,
-0.1684967,
... |
A long term time-lapse video system to document the patients spontaneous clinical seizure synchronized with the EEG. | A long term audio/video clinical seizure monitoring system is described which is complementary to a previously described EEG seizure monitoring system. The video unit is mobile and based on time-lapsed video recording techniques to extend the unattended continuous video recording of the patient to many days if necessar... | 79,480 | [
-0.226058,
0.09255048,
-0.349034,
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0.05334804,
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0.1775493,
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0.05019767,
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0.3844287,
-0.05605396,
-0.2280403,
0.08694273,
-0.07074686,
-0.04761966,... |
Intramitochondrial rodlet-like inclusions in human leukemic lymphocytes. | Some mitochondria in leukemic cells in two of nine investigated patients with chronic lymphocytic leukemia and in one patient with morphologically less usual form of this disease contained unusual rodlet-like inclusion bodies. These structures were always present in the matrix of frequently dilatated intercristal space... | 79,519 | [
-0.3937325,
-0.05182126,
-0.2044717,
0.1102772,
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-0.2977737,
-0.05367089,
0.08865786,
0.2346474,
0.4983808,
-0.0341592,
0.06510194,
-0.002440904,
0.4298184,
-0.339154,
0.1584965,
-0.4009794,
-0.1010844,
-0.1411148,
-0.1346977,
0.3549465,
0.108358,
0.1956105,
... |
Haematological changes in experimental hydralazine-induced collagen-like syndrome in guinea pigs. | Haematological studies were carried out in hydralazine-induced collagen-like syndrome in guinea pigs. 37.5 per cent of animals were found to be LE-positive. It was found that long-term administration of hydralazine caused a decrease of erythrocyte count, a decrease of haemoglobin concentration and a decrease of haemogl... | 79,526 | [
0.2171887,
-0.2126364,
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0.145526,
0.1146487,
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0.02633104,
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-0.03136876,
0.1146142,
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0.3070452,
0.01248412,
0.08508886,
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0.2493579,
0.005464613,
0.3319377,
0.08014379,
0.2304343,
-0.1375471,
... |
[Blood morphology of the European eel (Anguilla anguilla). IV. Thrombocytes and their developmental stages]. | By the aid of histological special stainings, cytochemical proofs, phase contrast and electron microscopical methods the thrombocytes (spindle cells) of the European ell (Anguilla anguilla) and their stages of development were described as an independent series of cells. After an artificial blood loss thrombocytoblasts... | 79,529 | [
0.1914383,
0.2941528,
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-0.2119014,
-0.03244429,
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0.09070794,
-0.1430101,
0.1848538,
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0.1311218,
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0.02150325,
-0.6220922,
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0.1869688,
-0.0389237,
0.3643294,
0.4169228,
0.1886392,
-0.1864941,
... |
Sequence of action of genes at the secretor, H, ABO and Lewis loci. | It is argued that Lewis genes are responsible for adding specificity to glycoprotein molecules after the activities of the secretor, H and ABO genes, respectively, have been expressed. This conclusion is based on the results of studies on the expression of ABO and Lewis antigens in salivas from Australian aborigines, a... | 79,541 | [
0.1733292,
-0.1964872,
-0.1689139,
-0.006343111,
0.06523003,
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-0.1516755,
0.03661249,
0.298463,
0.08531261,
0.4501064,
-0.09584945,
-0.2457784,
-0.1341298,
-0.283055,
-0.216939,
-0.1021992,
0.2116149,
-0.2968238,
0.3263751,
0.2026646,
-0.1938394,
... |
Angiotensin induced changes in blood glucose level. | Angiotensin given by intravenous route in rabbits caused a marked rise in blood glucose within 45 min. Guanethidine, bretylium, alpha methyl DOPA, adrenalectomy and reserpinization significantly influenced the changes in blood glucose induced by angiotensin II. It is suggested that the rise in blood glucose level induc... | 79,554 | [
-0.1194536,
-0.08432408,
-0.6141663,
-0.2034207,
-0.1407839,
-0.6154848,
-0.4342016,
-0.1591715,
0.2064759,
0.4269746,
0.2121453,
-0.1270423,
0.08029929,
-0.1315883,
-0.3624252,
0.1504358,
-0.4660925,
0.01017898,
0.1907802,
-0.1979901,
-0.1068967,
-0.09592709,
-0.06743294... |
Anaphylactoid reactions to iodinated contrast material. | A review of the literature involving anaphylactoid reactions to iodinated contrast material (ICM) suggests that the reactions are nonantibody-mediated but that a complex activation of inflammatory mediators occurs. Histamine release and/or complement activation has been demonstrated in both in vitro and in vivo experim... | 79,585 | [
-0.4634283,
-0.004507877,
0.01636523,
-0.03771552,
-0.06128383,
0.02810162,
-0.4969065,
0.07176929,
0.1501152,
0.0593297,
0.04400063,
0.2116246,
0.01334764,
-0.07132852,
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-0.2649669,
0.0422653,
-0.2353167,
0.1977965,
-0.06228371,
-0.08491357,
-0.067... |
Direct solid-phase radioimmunoassay for measuring antigenic differences between the hemagglutinins of influenza viruses. | A direct solid-phase radioimmunoassay, which involves binding of purified radio-labeled IgG to influenza virus hemagglutinins immobilized on Sepharose 4B gel, is described. | 79,617 | [
-0.04426777,
-0.09836893,
-0.1855998,
-0.03433707,
0.07054096,
-0.111916,
-0.2583685,
0.2730713,
-0.1323413,
0.1671699,
0.2403663,
0.09304724,
-0.1002253,
-0.06292929,
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-0.04489632,
-0.2761156,
0.2412276,
0.04551831,
-0.02722769,
0.5154006,
-0.1622444,
-0.262057... |
The immune response of allophenic mice to 2,4-dinitrophenyl (DNP)-bovine gamma globulin. I. Allotype analysis of anti-DNP antibody. | The question of whether or not lymphoid cells can cooperate across a histocompatibility difference barrier has been studied in several laboratories. Using an adoptive transfer system, Katz et al. (1) first showed that T cells from (low responder x high responder) F(1) mice, primed to the terpolymer L-glutamic acid, L-l... | 79,635 | [
0.238444,
-0.3100679,
-0.03294766,
0.1560073,
0.04023381,
0.08802035,
0.1894278,
0.09467343,
0.2606761,
0.1420998,
0.1399173,
0.2397883,
0.1265807,
0.3893396,
-0.7712812,
-0.1934491,
-0.2523451,
0.05785602,
-0.2158534,
0.2755066,
0.3162151,
-0.1758283,
0.1264877,
-0.351... |
New technique for measuring dynamic axonal transport and its application to temperature effects. | A new technique was devised for the dynamic detection of the axoplasmic transport of beta-radioactively labeled materials in which a semiconductor radiation detector was used as the beta-ray counter. The detector element is a silicon p-n junction diode and has a diameter of 2.0 mm. With this detector, the beta-radioact... | 79,636 | [
0.01170887,
-0.08980976,
-0.2292063,
0.204764,
-0.09871639,
-0.2766253,
-0.1493529,
-0.01449003,
0.1697438,
-0.07447952,
-0.1676423,
-0.3520437,
0.3119334,
0.004505575,
-0.4914005,
-0.5168976,
-0.5667077,
0.01609373,
0.1017408,
-0.004622169,
0.375097,
0.3924908,
0.1819003... |
Muscular carnitine synthesis and palmitate metabolism in vitro. | The carnitine content of the culture media for normal and pathological human muscles, including a case of systemic carnitine deficiency (SCD) was measured and the carnitine concentration was the same in all normal and pathological muscle culture media. Carnitine was never detected in growth medium. Some fibroblasts and... | 79,642 | [
-0.3282852,
-0.09629848,
0.02560526,
-0.08957518,
0.2355294,
0.2212782,
-0.4274308,
0.34475,
0.1232361,
-0.01297264,
0.1719538,
0.1792234,
-0.07283785,
0.4550267,
-0.2585494,
-0.1497937,
-0.2773871,
0.01409455,
-0.2517647,
0.3147159,
0.05156033,
0.2021913,
-0.178642,
-0... |
Doppler flow velocity measurements in patients with intracranial hypertension. | In patients with severe brain lesions monitoring of the intracranial pressure as well as monitoring of cerebral blood flow can be of clinical value. While at the moment there is no atraumatic method for measuring cerebral blood flow in man, it is recommended to measure blood flow velocity with the ultrasound Doppler te... | 79,643 | [
-0.1769635,
0.09560663,
-0.2474703,
-0.08880679,
0.1146223,
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-0.2306302,
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-0.04429114,
0.1215049,
0.06111928,
0.0258713,
-0.234507,
-0.1893197,
-0.2283627,
0.1442052,
-0.2945357,
0.1937466,
-0.3662044,
0.1200804,
0.02726605,
-0.1804236,
0.008331263,
... |
Differentiation of thyrotoxicosis induced by thyroid destruction from Graves' disease. | Thyroid function was tested in untreated patients with Graves' disease or thyrotoxic subacute thyroiditis, and in patients with autoimmune thyroiditis who showed postpartum or spontaneous transient thyrotoxicosis. The serum triiodothyronine/thyroxine ratio (T3/T4) was greater than 20 ng/microgram in Graves' disease but... | 79,711 | [
-0.1567798,
-0.3129038,
-0.1551906,
-0.05577609,
0.272368,
-0.2773895,
0.04887876,
0.122782,
-0.1268467,
0.08900113,
0.0388307,
0.1222155,
-0.1010122,
-0.05034933,
0.05141418,
-0.272961,
-0.6645214,
0.02353387,
0.05885009,
-0.1110252,
0.1793254,
0.3329624,
-0.1822533,
0... |
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