title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Isolation and characterization of Bacillus megaterium mutants containing decreased levels of spore protease. | A proteolytic activity present in spores of Bacillus megaterium has previously been implicated in the initiation of hydrolysis of the A, B, and C proteins which are degraded during spore germination. Four mutants of B. megaterium containing 20 to 30% of the normal level of spore proteolytic activity have been isolated.... | 99,436 | [
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Aspartate transcarbamylase synthesis ceases prior to inactivation of the enzyme in Bacillus subtilis. | Aspartate transcarbamylase is synthesized during exponential growth of Bacillus subtilis and is inactivated when the cells enter the stationary phase. This work is a study of the regulation of aspartate transcarbamylase synthesis during growth and the stationary phase. Using specific immunoprecipitation of aspartate tr... | 99,440 | [
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Separation and characterization of the outer membrane of Pseudomonas aeruginosa. | A method is described for the preparation of outer and cytoplasmic membranes of Pseudomonas aeruginosa, and the outer membrane proteins characterized. Isolated outer and cytoplasmic membranes differed markedly in the content of 2-keto-3-deoxyoctonate (lipopolysaccharide) and phospholipid as well as in the localization ... | 99,443 | [
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Estimation of antibodies specific for dextran. | Methods are described for the isolation and characterization of picogram quantities of anti-dextran antibodies. 14C-dextrans produced by using the dextransucrases of Leuconostoc mesenteroides strains B1355 and B512 were used in a radioimmunoassay. The specificity of this assay was verified by using cell cytoplasmic lys... | 99,480 | [
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Virulence of Mycobacterium tuberculosis and susceptibility to peroxidative killing systems. | At sub-bactericidal concentrations of hydrogen peroxide, Mycobacterium tuberculosis was killed by hydrogen peroxide/peroxidase/halide microbicidal systems. The halide cofactor could be either iodide or, with much lower efficiency, chloride. Omission of any one of the reactants eliminated the tuberculocidal effect. Diff... | 99,484 | [
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Catabolism and protein binding of Tc-99m pyridoxylideneglutamate. | Various Tc-99m-labeled compounds have been suggested as replacements for [I-131] rose bengal for imaging of the hepatobiliary system. Among such compounds are Schiff's bases, which are tin-free Tc-chelates easily prepared by 30-min autoclaving of an equimolar mixture of pyridoxal and an amino acid at pH 8.5. We have co... | 99,499 | [
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Polychlorinated dibenzofurans--potent inducers of rat hepatic drug-metabolizing enzymes. | The effects of polychlorinated dibenzofurans (PCDFs), trace toxic contaminants of commercial polychlorinated biphenyl preparations (PCBs), on the induction of hepatic drug-metabolizing enzymes were studied in the rat. PCDFs were about a thousand times more potent than PCBs (Kanechlor-500) as inducers of cytochrome P-45... | 99,592 | [
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[Pharmacotherapy of peripheral arteriosclerosis]. | Peripheral atherosclerosis was treated in 178 patients: 90 were given pyridinol carbamate for 2--4 months, 40 pentoxyphylline, 30 cetedil, and 18 received butalamine. in intermittent claudication pyridinol carbamate and trental proved most effective, cetedil (straten) was less effective. The favourable effect of pyridi... | 99,596 | [
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[Neuropathology of Chagas' disease]. | CNS involvement includes: 1) acute phase: scattered focal meningoencephalitic lesions, meningeal and cerebral edema, disseminated microgranulomas containing microgliocytes and situated in relation to cerebral blood vessels, and moderate cerebral fluid pleocytosis. Acute chagasic meningoencephalitis is always fatal, and... | 99,677 | [
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Subacute sclerosing panencephalitis (SSPE) agent in hamsters. | A hamster-adapted SSPE agent was shown to cause a productive infection in weanling hamster brain, which changed to a cell-associated or defective infection coincident with the appearance of measles antibodies in serum. Antibodies to measles hemagglutinin, hemolysin and neucleocapsid antigens developed in serum, which a... | 99,679 | [
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Familial chorea and myoclonus epilepsy. | A familial disorder was characterized by chorea, ataxia, myoclonus, convulsions, dementia, and mental retardation. In five cases, the main lesion affected cerebellar dentate nuclei, with nerve cell loss, gliosis, chromatolysis, and grumose degeneration. Fibrous glial cell proliferation was detected in the globus pallid... | 99,688 | [
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A comparison of intralingual and intravenous epinephrine before and during cardiovascular depression. | Dose-response methodology was used to evaluate the cardiopulmonary effects of epinephrine administered intravenously and intralingually to normotensive and acutely hypotensive dogs and monkeys. Results indicate that the intralingual route is much less effective than the intravenous route and that conventional doses of ... | 99,706 | [
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[Enlarge indications for controlled respiration (author's transl)]. | Controlled respiration should have a place not only in cases of hypoventilation but also in the treatment of comatose and hyperventilating persons. Hyperventilation is liable severely to interfere with the blood supply to the brain, and this disturbance, in conjunction with the primary disease responsible for the comat... | 99,735 | [
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Mechanisms of antibody diversity: multiple genes encode structurally related mouse kappa variable regions. | The complete amino acid sequences of the variable regions of three mouse Vkappa-21 kappa chains (A22, T111, and CB101) and one partial sequence (B32) have been determined and are compared to four previously reported Vkappa-21 variable regions. These eight kappa variable region sequences have, with the exception of an a... | 99,744 | [
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Lead poisoning treated with haemodialysis. | A 27-year-old woman ingested as an abortifacient 40 grams of litharge (PbO). She was treated with EDTA infusion and haemodialysis. The half-life of lead in the blood was 9 hours during combined haemodialysis and EDTA infusion and 96 hours when EDTA was given alone. Signs and symptoms attributable to acute lead intoxica... | 99,808 | [
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[Mobility measurements and histological studies on endosseous titanium implants under masticatory stress in the mandibles of adult macacas]. | Linkow blades were implanted into 5 adult monkeys. Measurements of mobility showed that two weeks after implantation the implant mobility was below the mobility of the control teeth. Fixed bridgework was inserted and after 8-14 months the mobility of implant and control teeth were alike. Inspite of this favourable resu... | 99,811 | [
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Productivity of ospreys in Connecticut--Long Island increases as DDE residues decline. | Nesting success of ospreys (Pandion haliaetus) breeding in the Connecticut--Long Island area has increased since 1973 and is now approaching the levels recorded prior to the 1950's. Simultaneously, DDE and dieldrin residues have declined in unhatched eggs. Levels of polychorinated biphenyls have shown no changes over t... | 99,818 | [
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Changes of cell cycle affecting cidal effect of triethylene thiophosphoramide on cultured human bladder carcinoma cells. | The cell cycle of the human bladder carcinoma cell line (MGH-U1 cells) was prolonged immediately after low dose of triethylene thiophosphoramide (Thio Tepa). Although the elongated cell cycle time seemed to return to the control level 48 hr following the treatment, there still remained postsynthetic accumulation and po... | 99,842 | [
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Serological, immunochemical and immuoncytological properties of granulocyte antibodies. | The immunochemical characteristics of granulocyte allo- and autoantibodies can easily be studied with indirect immunofluorescence techniques. The correlation of these properties with the serological behavior of the antibodies and the clinical condition in which they were found was studied. The investigations included t... | 99,875 | [
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The fate of brominated soya oil in the animal body. | 1. The bromine-containing material accumulated in tissues of rats dosed with brominated soya oil gradually decreased when the oil was no longer administered. 2. G.l.c. of the transesterified ether extracts of tissues from dosed animals showed 9,10-dibromostearic acid in extracts from fat, heart, kidney, liver and muscl... | 99,886 | [
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The role of certain oxidative enzymes, catalase, and beta-glucosidase on virulence of Cephalosporium maydis. | Isolates of Cephalosporium maydis varied in their pathogenicity to D.C. 67 maize cultivar from highly to weakly pathogenic. Highly pathogenic isolates showed lower activity of polyphenol oxidase, peroxidase, cytochrome oxidase, and beta-glucosidase enzymes and higher activity of catalase and dehydrogenase than weakly p... | 99,910 | [
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The measurement of serum proteins with rapid turnover for early diagnosis of fatal hepatitis. | An attempt was made to find reliable indices for the early recognition of fatal cases of acute viral hepatitis, using the values of serum proteins with rapid turnover. Prealbumin and alpha2-HS-glycoprotein were measured in the sera of 44 cases by immunodiffusion method before the appearance of hepatic coma and/or gastr... | 99,944 | [
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Electronmicroscopic cytochemical studies on lysosomes and peroxisomes of a rat cardiac muscle in the experimental alloxan diabetes. | The combined electronmicroscopic and cytochemical investigations of lysosomes and peroxisomes of a rat cardiac muscle were carried out in various duration time of the alloxan diabetes. The analysis of cytochemical reactions with DAB, confirming the existence of peroxisomes in rat heart muscle revealed that the state of... | 99,963 | [
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[About the differentiation of antibodies against the connective tissue (author's transl)]. | Unfixed cryostat sections of an organ block comprising the liver, stomach, and kidney of rats as well as the kidney of mice were used as antigenic substrate for detecting antibodies against connective tissues by indirect immunofluorescence. There were found more than 14 different fluorescent patterns. Two types could b... | 99,965 | [
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Regional developmental and fractional studies on myelin and other carbonic anhydrases in rat CNS. | Myelin carbonic anhydrase (CA) was studied with respect to its development in various brain regions and light and heavy myelin (LM and HM). The data indicate that the specific activity of myelin CA has a clear neuraxial distribution, increasing rostrally. The absolute activities and relative distribution are invariant ... | 99,992 | [
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Patient-specific total parenteral nutrient formulas. | A method of formulating total parenteral nutrient (TPN) solutions to meet specific patient requirements is discussed. A series of calculations is presented which results in a specific formula that provides the required nutrients. The input data for the calculations are the patient's 24-hour requirements for protein, ca... | 100,009 | [
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Chrysotherapy-induced aplastic anemia: a case report. | A case of gold-induced aplastic anemia occurring in a 58-year-old male with rheumatoid arthritis who received a total dose of 635 mg of gold sodium thiomalate over a 16-week period is reported. The clinical features, treatment, prevention and pathogenesis of gold-induced aplastic anemia are reviewed. The ability to pre... | 100,010 | [
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Transplantation of pancreatic beta-cells prevents development of hypothalamic obesity in rats. | The present experiments have tested the hypothesis that ventromedial hypothalamic (VMH) lesions enhance insulin secretion by neural mechanisms. Rats were made diabetic by injecting streptozotocin to destroy their own pancreatic beta-cells. Subsequently, transplants of fetal pancreatic tissue were placed under the renal... | 100,013 | [
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... |
Carbonic anhydrase in the generation of cochlear potentials. | The experiments on 18 guinea pigs were divided into two groups and each group was arranged in such a way that the effect of hypercapnia (generated by breathing 10% CO2-90% O2) was investigated with and without inhibition of carbonic anhydrase by methazolamide, 25 mg/kg, in the first group and acetazolamide, 50 mg/kg, i... | 100,017 | [
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[Induction of interferon by Bacillus subtilis (author's transl)]. | Although it is generally admitted that Gram-positive bacteria cannot induce interferon, we were able to show that organisms and cell walls of Bacillis subtilis as well as components obtained through the extraction of endotoxins from Gram-negative bacteria can induce type II interferon. Moreover we have ascertained that... | 100,036 | [
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Animal model for the 4-kHz tonal dip. | In humans, noise exposures produce permanent hearing losses which usually begin at 4 kHz. In chinchillas, a similar pattern of hearing loss was observed following exposure for 9 or 18 days to an octave band of noise with a center frequency of 0.5 kHz. Histopathological observations of cellular degeneration showed that ... | 100,042 | [
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[Method of determining the antimicrobial activity of alcohol extracts of propolis]. | It is proposed to determine the antimicrobial activity of propolys alcohol extracts by the method of subsequent dilutions in solid nutrient media. Dilution of the extracts immediately in hot agar eliminated the inhibiting effect of the extragent on the microbial growth. Opalesence appearing in the agar did not prevent ... | 100,047 | [
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Rosette formation by human lymphoid cells with monkey red blood cells. | The present paper describes a study on rosette formation by human lymphoid cells with monkey erythrocytes (MRBC) obtained from two species: African green monkey (Cercopithecus aethiops) and rhesus monkey (Macaca mulata). All the lymphocyte preparations obtained from peripheral blood, tonsils, thymocytes, bone-marrow an... | 100,044 | [
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Effects of dispersed recreational activities on the microbiological quality of forest surface water. | The microbiological quality of forest surface waters in the Greenwater River watershed was examined to investigate the influence of heavy motorized camping in an area with no sanitary facilities. Indicator densities increased during weekend human-use periods when compared to weekdays. Increases in indicator densities w... | 100,055 | [
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Denitrifying Pseudomonas aeruginosa: some parameters of growth and active transport. | Optimal cell yield of Pseudomonas aeruginosa grown under denitrifying conditions was obtained with 100 mM nitrate as the terminal electron acceptor, irrespective of the medium used. Nitrite as the terminal electron acceptor supported poor denitrifying growth when concentrations of less than 15 mM, but not higher, were ... | 100,056 | [
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Morphology of freeze-etched Treponema refringens (Nichols). | The freeze-etch technique was used to study the morphology of Treponema refringens (Nichols). There is a single band of cytoplasmic fibrils which follows a path in the form of a right-handed helix with a periodicity of 1500 nm around the body of the treponeme just below the cytoplasmic membrane. There are two major fra... | 100,069 | [
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Acute toxicity in poults associated with carbaryl insecticide. | Death of young poults is described as probably due to abuse of carbaryl in turkey pens (14 times the recommended dose). Method of application was not as described by the manufacturer. | 100,099 | [
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Studies of the binding of different iron donors to human serum transferrin and isolation of iron-binding fragments from the N- and C-terminal regions of the protein. | 1. Trypsin digestion of human serum transferrin partially saturated with iron(III)-nitrilotriacetate at pH 5.5 or pH 8.5 produces a carbohydrate-containing iron-binding fragment of mol.wt. 43000. 2. When iron(III) citrate, FeCl3, iron (III) ascorabate and (NH4)2SO4,FeSO4 are used as iron donors to saturate the protein ... | 100,104 | [
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BRL10833 in inhibiting exercise-induced bronchoconstriction in asthmatic children. | A double-blind controlled exercise challenge study has been performed in 16 asthmatic chlidren to show the effectiveness of BRL10833 in inhibiting exercise-induced bronchoconstriction. The children attended the respiratory laboratory on four occasions within the space of two weeks; on each occassion a routine 6-min exe... | 100,129 | [
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Light chain variable region sequence of rabbit antipneumococcal type III polysaccharide antibody 3368. | The amino acid sequence of the amino-terminal 111 residues (variable region) for the light chain of the homogeneous rabbit antipneumococcal type III polysaccharide antibody 3368 was determined. This sequence was obtained principally through automated Edmann degradations of the intact light chain and of peptides generat... | 100,133 | [
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Influence of dietary calcium selenium and methylmercury on eggshell thickness in Japanese quail. | A high Ca, semi-purified diet promoted greater egg production with thicker shells in Japanese quail hens. 7 ppm of dietary Se depressed egg weights with no effect on eggshell thickness. The addition of 20 ppm of MHg to either a low or high Ca diet containing Se depressed both egg production and eggshell thickness. Se r... | 100,155 | [
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Total skin electron beam therapy in mycosis fungoides. | Thirty-nine patients with mycosis fungoides were treated with total skin electron beam irradiation from 1971 to 1976, and all received minimum follow-up of 12 months. Details of treatment technique and dosimetry are given. Sixteen patients cleared completely. Seven patients are in long-term remission (1 1/2 to 4 1/2 ye... | 100,206 | [
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0.02889... |
Natural history of papillary lesions of the urinary bladder in schistosomiasis. | Variable epithelial hyperplasia was observed in urinary bladder of nine capuchin monkeys (Cebus apella) when examined at cystotomy 94 to 164 weeks after infection with Schistosoma haematobium. These hosts were followed for 24 to 136 weeks postcystotomy to determine the status of bladder lesions in relation to duration ... | 100,209 | [
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Vasopressin stimulation of acetate incorporation into lipids in a dimethylbenz(a)anthracene-induced rat mammary tumor cell line. | In a preliminary report we described the effects of rat prolactin on the incorporation of [14C]acetate into lipids by a cell line from a dimethylbenz(a)anthracene-induced rat mammary tumor. The characteristics of the response to prolactin were very similar to those described for the normal rat mammary gland; namely, in... | 100,217 | [
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Stress testing and working capacity in Chagas' cardiomyopathy. | The EKG response to exercise and the working capacity in a group of 70 patients with positive serology for Chagas' disease has been determined by stress testing on a bicycle-ergometer, in order to establish the usefulness of such a test in the early diagnosis of Chagas' cardiomyopathy. The exercise EKG provides informa... | 100,220 | [
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Immunofluorescence study of the hypothalamo-infundibular LRH tract and serum gonadotropin levels in the female squirrel monkey during the estrous cycle. | The study of LRH reactive neurons of the medial basal hypothalamic group was made with rabbit antisera to unconjugated synthetic LRH, in normally cycling female squirrel monkeys. The specifically immunoreactive material present along the hypothalamo-infundibular LRH tract shows significant modifications that are partic... | 100,222 | [
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Factors affecting the binding of polycyclic aromatic hydrocarbons to human embryo cells, and transformable and non-transformable hamster embryo cells. | The effects of various factors, including population doubling number, percent of confluence, serum concentration and storage in liquid nitrogen on the binding of several polycyclic aromatic hydrocarbons to human and hamster embryo cells were studied. The binding of 7,12-dimethylbenz[a]-anthracene (DMBA) to hamster embr... | 100,230 | [
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[The effect of anesthetics on the basal secretion of immunoreactive growth hormone in rats]. | The authors investigated basal levels of plasma immunoreactive growth-hormone in the rat (R-GH) after administration of 3 different anesthetic drugs: urethan, chloral hydrate and gamma-hdroxy-butyrate (GHB). Lowest R-GH concentrations (5 +/- 3 ng/ml) are observed after urethan; they are significantly higher (15 +/- 4 n... | 100,239 | [
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... |
[Origin of a mitogrenic factor for cultivated macrophages (IMF: Inflammatory Mitogenic Factor) found in exudates of non-specific acute inflammation]. | The mitogenic activity of inflammatory exudate obtained from irradiated Rats is reduced. After transfer of bone marrow syngeneic cells into irradiated Rats this mitogenic activity is further decreased, while after transfer of thymic cells it is increased. It is postulated that the mitogenic activity of inflammatory exu... | 100,246 | [
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Thyroid function in early sub-acute thyroiditis. | A 53-year-old woman with an early form of de Quervain's disease involving both thyroid lobes was found to have her thyroid uptake of iodine suppressed, although the serum thyroid hormone concentrations were normal while the administration of TRH resulted in significant increase in the serum TSH concentrations. After ad... | 100,262 | [
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[Somatosensory evoked cortical potentials (SSEP) in regenerating nerves following suture (author's transl)]. | In 37 patients with sutured median and ulnar nerves 106 SSEP were evaluated. Stimulation of the finger nerves was performed at a rate of 4-6/sec. In the early stage of reinnervation, just when the electrical stimulus was perceived, the second positive component (P2) of the SSEP could be recorded, but the primary part o... | 100,312 | [
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The detection of cysteine-homocysteine mixed disulphide in plasma of normal fasting man. | Cysteine-homocysteine mixed disulphide, formed in the degradation of methionine, is detected routinely in the plasma of fasting patients homozygous for homocystinuria and in some obligate heteroxygotes. It has not hitherto been identified in the plasma of normal fasting man. Using a highly cross-linked resin with lithi... | 100,323 | [
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Experience with high doses of ibuprofen in the long-term treatment of rheumatoid arthritis. | Ibuprofen (Brufen) is a non-steroidal anti-inflammatory drug well-established in the symptomatic treatment of rheumatoid arthritis. In view of its exceptionally good tolerance it has become fashionable to prescribe increasingly large doses for severe cases or in those patients unable to tolerate other anti-rheumatic co... | 100,352 | [
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Susceptibility of 327 clinical isolates to netilmicin. | Netilmicin, a semisynthetic derivative of sisomicin, was tested against 327 isolates of Staphylococcus aureus, Pseudomonas aeruginosa and Gram-negative enteric bacilli. Seventy-two per cent of the isolates were inhibited at a concentration of 0.5 microgram netilmicin per ml, and 93% of the isolates were susceptible to ... | 100,353 | [
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... |
Can the United States learn from foreign medical insurance systems? | After data are given on trends in health care expenditures in several nations, selected health care cost indicators in Canada and in the United States are contrasted in more detail; and a study of the Canadian health care insurance system is criticized. Finally some broader questions on the nature of U.S. social policy... | 100,406 | [
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Chromosomal investigations in children with pyknolepsy on dipropylacetate monotherapy. | We analyzed chromosome preparations obtained from leukocytes of ten children with pyknolepsy and treated with dipropylacetate (DPA) as monotherapy. Structural or numerical aberrations were not found more frequently in our patients than in five normal children (control group). | 100,408 | [
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0.154576,
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0.093253,
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-0.167... |
Human triclonal anti-IgG gammopathy. I. Iso-electric focusing characteristics of the IgG, IgA and IgM anti-IgG and their heavy and light chains. | Human IgG, IgA and IgM anti-IgG autoantibodies have been isolated from the serum of an individual with Felty's syndrome. These were initially noted as soluble circulating serum complexes by analytical ultracentrifugation. Isolation was accomplished by solid phase immunoadsorption and each of the three antibody populati... | 100,416 | [
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Role of the meniscus in the etiology of posttraumatic temporomandibular joint ankylosis. | From an analysis of the factors that could contribute to the development of post-traumatic TMJ ankylosis, it is evident that a number of different conditions are probably operant. Based on clinical and experimental findings, however, it is suggested that of primary importance is the location of the meniscus in relation... | 100,450 | [
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Physiotherapy in diagnosis and treatment of the myofascial pain dysfunction syndrome. | Thirty-four patients with the Myofascial Pain Dysfunction (M.P.D.) syndrome of the masticatory system were investigated and treated using physiotherapy techniques. Resisted static contraction of the temporomandibular joints, passive movement tests of the muscles and electromyography indicated that the joint function wa... | 100,453 | [
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Release of mandibular ankylosis due to gross tissue loss in the cheek. | Experience with mandibular ankylosis due to the loss of variable amounts of cheek tissue as a result of cancrum oris is reviewed. Where enough cheek has been lost to cause an ankylosis, replacement tissue in the form of a graft is necessary to prevent recurrence and to reconstruct the cheek. A number of methods are rev... | 100,454 | [
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Follow-up investigation of reconstruction of the alveolar process in the atrophic mandible. | In this article the results are presented of the reconstruction of the alveolar process with iliac crest bone grafts in 14 patients. In all cases in a second operation a vestibuloplasty and a floor-of-mouth plasty was done. After an average follow-up period of 39 months, almost complete resorption of the bone grafts wa... | 100,459 | [
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Norwalk agent-like particles associated with gastroenteritis in human beings. | Currently, 6 agents of viral gastroenteritis with properties similar to the Norwalk agent have been described. These are the Hawaii, Montgomery County, W, Ditchling, and Cockle agents, as well as the Norwalk agent. These agents are 25 to 27 nm in diameter, are nonenveloped, and have a buoyant density of 1.38 to 1.40 g/... | 100,481 | [
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Immunological comparison of the proteins of chicken and rat liver ribosomes. | A comparison of the proteins of chicken and rat liver ribosomes using immunochemical techniques was undertaken. The procedures included quantitative precipitation, passive hemagglutination, and immunodiffusion on Ouchterlony plates. The results indicate that antisera specific for chicken or rat liver ribosomes recogniz... | 100,494 | [
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Identification of Neisseria gonorrhoeae from primary cultures by a slide agglutination test. | Hen antigonococcal lipopolysaccharide hen serum was used in a simple slide agglutination test for the identification of Neisseria gonorrhoeae from primary isolates. | 100,511 | [
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Third component, HBeAg/3, of hepatitis B e antigen system, identified by three different double-diffusion techniques. | A third component, HB(e)AG/3, of the hepatitis B e antigen system has been detected, and it was consistently detected in three variations of the double-diffusion technique. | 100,512 | [
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Ultrasonic calculation of chorion cavity volume. | A method for calculating chorion cavity volume in the first trimester of pregnancy from the ultrasonic projection of the gestation sac is described. The area of the longitudinal and transverse sections were measured, and the volume was calculated from the mean value of the two measurements. The chorion cavity volume in... | 100,522 | [
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Alternative pathways of T lymphocyte activation. | Data presented in this paper suggest that there may be two alternative pathways which T lymphocytes can use in generating a cytotoxic response to alloantigens in vitro. First, there is the pathway taken when stimulator and responder cells differ by an entire H-2 complex where Ly1+2- helper T lymphocytes respond to I re... | 100,571 | [
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Therapy of gonorrhea. Comparison of trimethoprim-sulfamethoxazole and ampicillin. | Eighty-nine men with gonococcal urethritis were randomly treated with trimethoprim-sulfamethoxazole, four tablets (trimethoprin, 320 mg, and sulfamethoxazole, 1,600 mg) twice daily for two days, or ampicillin, 3.5 g, plus probenecid, 1 g, in a single dose. Forty-one (95.3%) of 43 patients who received trimethoprin-sulf... | 100,624 | [
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Antigenic relationship of two strains of simian hemorrhagic fever virus. | Serological comparison of the prototype and an epizootic (Corbell) strain of simian hemorrhagic fever virus revealed that the two viruses were serologically similar. The prototype strain differs from the Corbell strain in that the latter cannot be cultivated in vitro. Serological comparison of the prototype virus grown... | 100,652 | [
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Suspected ascorbic acid deficiency in a colony of squirrel monkeys (Saimiri sciureus). | Subperiosteal cranial hematomas were observed in five female squirrel monkeys. The absence of trauma in the clinical history, the characteristic clinical changes, and the pathological lesions suggested that the animals were scorbutic. Analysis of feed which was soaked in water, or left on the ground for varying time pe... | 100,654 | [
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E.N.T. manifestations of Von Recklinghausen's disease. | Von Recklinghausen's Disease (VRD) is a neurocutaneous, systemic disease characterized by CNS tumors and disorders, cafe-au-lait spots, generalized cutaneous neurofibromata, skeletal deformities, and somatic and endocrine abnormalities. It is an autosomal dominant, hereditary disorder found in approximately 1:2500 to 3... | 100,661 | [
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Intramural diverticulosis of the esophagus. | A description is given of the etiology and pathology of intramural esophageal diverticulosis as so far discussed in the literature. In view of the course and the clinical findings in two young patients in whom this diagnosis was established, it is suggested that intramural diverticulosis develops as a result of a devol... | 100,662 | [
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[Amino acid makeup characteristics of bacteria utilizing nonnatural compounds]. | A peculiarity of the amino acid pool has been discovered for the first time in bacteria utilizing such synthetic compounds as gamma butyrolactam, epsilon-caprolactam and zeta-aminoenanthic acid. The main components of the amino acid pool are omega-aminoacids (including synthetic ones) as well as glutamic acid. The tota... | 100,669 | [
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Maternal syndrome associated with hydrops fetalis: case report. | A case of maternal fluid retention syndrome associated with fetal hydrops due to rhesus isoimmunisation is reported. The aetiology and clinical features are discussed. Prophylactic anti-Rh immunoglobin should reduce the incidence of such cases in the future. | 100,749 | [
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Circadian activity rhythms of the pig-tailed macaque, Macaca nemestrina, under constant illumination. | Locomotor activity was recorded in singly caged pig-tailed macaques Macaca nemestrina in constant conditions with intensities of illumination varying between 0.003 lux and 100 lux. Each animal was kept in at least 5 different conditions for 2-3 weeks each. Three quantities of the circadian rhythm: the period, the durat... | 100,764 | [
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RNA metabolism, manganese, and RNA polymerases of zinc-sufficient and zinc-deficient Euglena gracilis. | The three major RNA classes from zinc-sufficient [(+Zn)] and zinc-deficient [(=Zn)] Euglena gracilis have been separated by affinity chromatography on oligo(dT)- and N-[N'-[m-(dihydroxyboryl)phenyl]succinamoyl]aminoethyl (DBAE)-celluloses. The total RNA content and the ribosomal and transfer RNA fractions are the same ... | 100,782 | [
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High-affinity 3H-serotonin binding to caudate: inhibition by hallucinogens and serotoninergic drugs. | The specific binding of 3H-serotonin to calf caudate homogenate was studied. The dissociation constant was 2nM and the number of specific sites was 14fmoles/mg protein. Of many drugs tested, inhibition of specific 3H-serotonin binding occurred almost exclusively with serotonin agonists and antagonists. The concentratio... | 100,806 | [
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A near-lethal dose of ethanol, given intraperitoneally, does not affect memory consolidation of two different avoidance tasks. | Ethanol (3 g/kg, given i.p. as a 33% w/v solution), was given to adult Wistar rats 1 min after training in (1) a 50-trial session of shuttle avoidance, using buzzers and shocks, and (2) an inhibitory avoidance experience in a step-through apparatus. The animals were retested 7 days after training in condition (1), and ... | 100,817 | [
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[Uremic pericarditis: clinical aspects, echocardiography, therapy]. | Over a 2-year period uremic pericarditis was observed in 11 of 62 patients treated by chronic dialysis. The uremic state appeared to be the most important contributing factor in these patients. Chest pain, fever and a pericardial friction rub were observed in the majority of patients; the illness may however be silent.... | 100,877 | [
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The comprehensive child health care centres in the Sudan. | In 1963, Morley initiated the concept of clinics for children under five years old. This paper describes our experience in applying that concept in Omdurman town (Sudan) where existing maternity and child health centres and hospitals in the area were involved in the scheme. It was found necessary to establish a main ce... | 100,909 | [
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... |
[Examination of market carps for residues of antimicrobial agents]. | The residues of inhibitory substances in the muscle, hepatopancreas, bile, and pyloric caeca of 30 carps from ponds south of Brno were examined by the microbiological diffusion method. The following testing micro-organisms were used: B. cereus var. mycoides (ATCC 11778), B. subtilis (ATCC 6633), Sarcina lutea (ATCC 934... | 100,930 | [
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Intermediate (10 nm) filaments in human malignant mesothelioma. | Human malignant mesotheliomas were studied by electron microscopy. Three main types of cells were seen--submesothelial epithelioid cells, epithelial lining cells and fibroblast-like cells. In submesothelial epithelioid cells prominent arrays of intermediate (10 nm) filaments were often seen attached to plasma membrane,... | 100,958 | [
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[Relationship between aminoglucuronide synthesis in the bodies of white rats and the physico-chemical properties of the substrate]. | In rats 5-substituted 2-aminobenzophenones (R-NH2; CH3; Cl) formed N-glucuronides. Amounts of free substances and of the glucuronyl-conjugates, excreted with the urine, depended on the nature of the radical; the derivatives differed in the values of Hammet's constants, in the lipophility and alkalinity. Estimation of H... | 100,967 | [
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-0.2193556,
... |
Calcified bodies in popliteal cysts: a characteristic radiographic appearance. | Calcified bodies in popliteal cysts have a characteristic radiographic appearance which can be confirmed by arthrography. Calcified bodies may arise in the true joint due to trauma, arthropathy resulting in joint destruction, or synovial osteochondromatosis. These calcified loose bodies may pass into a popliteal cyst t... | 101,044 | [
-0.2563883,
0.2019089,
0.1757982,
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0.2903225,
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0.009219501,
0.3651853,
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0.07550786,
0.005321354,
-0.1240038,... |
Use of a xenon flash tube as the excitation source in a new slit-lamp fluorophotometer. | A new objective fluorophotometer measures fluorescein mass or concentration in the cornea or anterior chamber. The excitation source is a xenon flash tube that allows the measurement of fluorescence to be made rapidly and conveniently. The instrument is designed for use in clinical studies requiring quantitative measur... | 101,087 | [
-0.297191,
0.002041054,
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0.1675403,
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-0.09128351,
0.02956804,
0.2994398,
-0.1352854,
0.16976... |
A quantitative approach to cytoarchiterctonics. II. The allocortex of Tupaia belangeri. | Fourteen allocortical areas of Tupaia belangeri are described after measuring the grey level index (Zilles et al., 1978b) with a new, automatic, high resolution measuring procedure. The laminar pattern of the cortical areas is quantitatively described after vertical changes in this index occurred from the pial surface ... | 101,095 | [
0.1907584,
0.2397463,
0.1472501,
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0.2508281,
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0.05627772,
0.04536463,
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0.12493,
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0.2073489,
0.2918949,
0.05647788,
-0.036382... |
Possible mechanisms of emphysema in smokers. In vitro suppression of serum elastase-inhibitory capacity by fresh cigarette smoke and its prevention by antioxidants. | Freshly prepared, aqueous solutions of cigarette smoke suppressed the elastase-inhibitory capacity of human serum. Immunoelectrophoresis of mixtures of aqueous smoke solution, human serum, and pancreatic elastase showed decreased elastase/alpha1-proteinase inhibitor complexes and increased free, active protease. Phenol... | 101,105 | [
0.1291454,
0.2713104,
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0.09362642,
0.02700548,
0.07366986,
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0.2997174,
0.0493069,
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0.2684664,
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0.002116576,
0.148525,
0.06452387,
-0.01156623,
0.1322695,
-0.2492584,
... |
The role of early left-brain injury in determining lateralization of cerebral speech functions. | Preparatory to craniotomy for the relief of medically refractory focal epilepsy, the lateralization of cerebral speech functions was determined by the Wada intracarotid Amytal test in 134 patients with clinical and radiologic evidence of an early left-hemisphere lesion. Their results were compared with those for 262 pa... | 101,116 | [
-0.109488,
-0.08886032,
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0.1591204,
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0.2169834,
0.4837987,
0.04701003,
0.2534548,
0.02078646,
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0.1526763,
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0.2511846,
0.09431629,
-0.6958385,
-0.07467354,
-0.006698866,
-0.110653,
-0.08669738... |
Effect of hydrostatic tensile stress on the growth of Escherichia coli and Bacillus cereus. | The specific growth rates of Escherichia coli and Bacillus cereus were measured for growth media in a flask, a lens-plate arrangement simulating an isolated capillary space, and a lens-plate arrangement under hydrostatic tensile stress. The specific growth rates of the bacteria were the same for the flask and lens-plat... | 101,141 | [
-0.07864045,
-0.09447396,
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0.09267876,
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0.07538531,
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-0.3217906,
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0.2016012,
-0.03927222,
0.3586539,
-0.3908345,
-0.03231187,
0.6768327,
0.04659481,
0... |
Physiological and histological effects of cerebellar stimulation. | Cerebellar implants have been placed in 62 patients with postoperative follow-up of 4 months to 3 years. Initially currents were applied through electrodes of alternate polarity on the superior surface of the cerebellar hemispheres and subsequently through negative electrodes on the superior surface to positive electro... | 101,138 | [
-0.1459706,
0.01028255,
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0.03960295,
0.04378445,
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0.05057384,
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-0.2540644,
-0.1031255,
-0.348117,
0.02197241,
0.09852648,
0.1806085,
0.218059... |
[Incidence of hyperuricemia in atrioventricular block. Systematic study of 158 cases which required implantation of an isotopic cardiac pacemaker]. | This is a study of 158 patients in whom the placement of an isotopic cardiac pacemaker was indicated; this procedure was carried out Broussais Hospital between 1970 and 1975. These patients, whose mean age was 39 (84 males, 47 females, 12 young men and 15 young women) were examined for uricaemia, and the levels compare... | 101,170 | [
0.009127196,
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-0.323556,
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-0.3369993,
-0.07431564,
0.1223669,
0.4011556,
-0.1988066,
0.01368416,
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-0.3785797,
-0.1859041,
0.1020595,
0.08549397,
-0.2137738,
0.2202418,
0.2442511,
-0.342895... |
[Role of diuretics in arterial hypertension]. | The place of diuretics in the treatment of hypertension (HT) no longer requires to be proved, but their mode of action remains uncertain. Blood volume measurements allow us to distinguish the cases of HT which are volume-dependent, and which constitute the major indication for this type of treatment. The various groups... | 101,179 | [
-0.08686379,
0.05902322,
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0.3761106,
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0.01278352,
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-0.07769561,
0.2082701,
0.1821429,
0.08518238,
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-0.08480231,
0.2486957,
-0.02341847,
0.2752727,
0.3705475,
0.03730079,
-0.1907... |
Metabolism and the triggering of germination of Bacillus megaterium. Concentrations of amino acids, organic acids, adenine nucleotides and nicotinamide nucleotides during germination. | A considerable amount of evidence suggests that metabolism of germinants or metabolism stimulated by them is involved in triggering bacterial-spore germination. On the assumption that such a metabolic trigger might lead to relatively small biochemical changes in the first few minutes of germination, sensitive analytica... | 101,212 | [
-0.05893154,
0.2290879,
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0.09873343,
0.07174078,
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0.1291591,
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0.1275474,
0.4495481,
0.174489,
0.06595508,
-0.6812752,
0.02104278,
-0.2114229,
0.1818595,
0.05348998,
0.1590744,
0.8485869,
0.2172303,
-0.01202788,
0.... |
Comparison of atenolol with propranolol in the treatment of angina pectoris with special reference to once daily administration of atenolol. | Fourteen patients with angina pectoris completed a double blind trial of atenolol 25 mg, 50 mg, and 100 mg twice daily and propranolol 80 mg thrice daily. In comparison with placebo, all active treatments significantly reduced anginal attacks, consumption of glyceryl trinitrate, resting and exercise heart rate, resting... | 101,223 | [
-0.3646964,
0.256097,
-0.6339335,
-0.07850102,
-0.04293978,
-0.1078714,
-0.2722791,
-0.3643597,
-0.01591166,
-0.3663834,
-0.03743942,
0.298616,
-0.129729,
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-0.1691429,
-0.1990042,
-0.5131546,
0.2727415,
-0.1282798,
0.1295302,
-0.1891271,
0.136655,
-0.01458794,... |
Changes in conformation and immunological activity of ovalbumin during its modification with different acid anhydrides. | In order to probe the cause and nature of conformational changes induced by the chemical modification of amino groups in proteins, five acylated derivatives of ovalbumin namely 21% acetylated, 32% succinylated, 90% butyrated 92% succinylated, and 95% acetylated ovalbumins were prepared and their molecular and immunolog... | 101,249 | [
0.1875416,
0.0167868,
0.008367999,
0.3941966,
0.0793074,
-0.3725151,
-0.04836563,
0.09203041,
0.07414767,
0.1280943,
-0.0003753162,
-0.4628329,
0.01383857,
-0.07953833,
0.1516387,
0.1064582,
-0.5742534,
0.1564483,
0.08239884,
0.1108154,
-0.03287216,
0.1617293,
-0.1876268,... |
[Transplacental penetration of 7,12-dimethylbenz(a)anthracene and its distribution in the organs of rat fetuses]. | Rats were given 7,12-dimethylbenz(a)anthracene (DMBA) intravenously in a dose of 15 mg/kg on the 21st day of pregnancy; its content in the liver, placenta, and the fetus was determined by the fluorescent-spectral method. The maximal concentration was reached in 10--15 min in the liver and placenta of the pregnant rats ... | 101,257 | [
-0.15325,
-0.2626886,
-0.09370501,
0.03597511,
0.3216805,
-0.3832928,
-0.3982161,
-0.0632467,
-0.152197,
-0.05372763,
0.1318087,
-0.05801727,
0.4281,
-0.2586721,
-0.7238997,
-0.3039635,
-0.5883195,
0.1874676,
0.04039474,
0.1213865,
0.560598,
0.310727,
-0.03434857,
0.075... |
Electroencephalographic studies myoclonus. | Electroencephalographic studies were carried out in 30 patients with various kinds of myoclonus. It was confirmed that the technique of jerk-locked averaging with a backward averaging program was useful for detecting cortical spikes in association with the spontaneously occurring myoclonus, which are not recognized on ... | 101,279 | [
-0.1026655,
0.06514319,
-0.15928,
-0.2481328,
-0.02127635,
-0.1228988,
-0.1989186,
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0.1257557,
0.3733437,
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0.2084713,
0.2815054,
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-0.2403621,
0.02520011,
-0.2024558,
0.01241033,
0.3750737,
0.199278,
0.1600387,
... |
The production of toxic metabolites by Chaetomium spp. isolated from solis of permanent pasture. | One hundred and two isolates of Chaetomium spp. have been identified from 2563 soil samples collected from permanent pasture at Nappan, Nova Scotia. Chaetomium umbonatum was the Chaetomium species most commonly isolated. Fifty-six of the Chaetomium isolates were grown in the laboratory and the cultures examined for the... | 101,287 | [
0.005224792,
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0.07105576,
0.1246631,
-0.09152929,
-0.3910757,
-0.2006885,
0.2898513,
-0.1203913,
-0.1308157,
-0.3222067,
0.1864548,
0.07867627,
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0.09249668,
-0.315326,
0.1689375,
0.1967367,
-0.04926602,
-0.1186399,
0.5913212,
-0.155409,
... |
Serum thyroxin levels during hyperthermia evoked in the monkey by intrahypothalamic injection of PGE1, 5-HT or pyrogen. | Serotonin (5-HT), prostaglandin E1 (PGE1) or a bacterial pyrogen (E. coli or S. typhosa) was microinjected in a volume of 1.0--1.5 microliter into the hypothalamus of the unanesthetized monkey to evoke a long-term hyperthermia. Samples of venous blood collected every 15 min, before, during and after each fever were ana... | 101,286 | [
-0.1094558,
-0.02340508,
-0.4848573,
-0.2631252,
-0.2174642,
-0.1236206,
-0.2987455,
-0.08475911,
-0.1305873,
-0.02764292,
0.3890169,
-0.165364,
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0.04188741,
0.1369787,
-0.02702106,
0.1623003,
0.2885431,
0.3043499,
0.2367359,
-0.2056514... |
Clinical investigation of agents with prophylactic anti-allergic effects in bronchial asthma. | To determine the efficacy of ketotifen as an oral anti-asthmatic agent, experimental and therapeutic long-term trials were carried out. Four models were used in the expirmental therapeutic trials nad the antihistaminic agent clemastine and disodium cromoglycate were used as comparative substances. It was demonstrated t... | 101,313 | [
-0.1537639,
0.1388747,
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0.07031337,
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0.06309552,
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0.02512824,
0.05305658,
0.2497365,
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0.1617107,
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0.1416358,
-0.08105148,
-0.1895034,
-0.04298185,
0.07844092,
0.005536646... |
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