title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Survival outcome and reduction rate of Ki-67 between pre- and post-neoadjuvant chemotherapy in breast cancer patients with non-pCR. | The research question of this investigation is whether the reduction rate of Ki-67 after neoadjuvant chemotherapy (NAC) could indicate a survival in patients with non-pCR. A total of 455 patients had received NAC, and subsequent surgery was analyzed retrospectively. Patients with non-pCR were divided into three subgrou... | 25,106,660 | [
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Pollution biomonitoring in the Bizerte lagoon (Tunisia), using combined chemical and biomarker analyses in grass goby, Zosterisessor ophiocephalus (Teleostei, Gobiidae). | In this study, biological responses and contaminant levels in biological tissues were investigated in grass goby fish specimens (Zosterisessor ophiocephalus) collected from five stations in a moderately polluted ecosystem, namely the Bizerte lagoon on the north coast of Tunisia. The following biomarkers were measured: ... | 25,106,667 | [
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CD18 deficiency evolving to megakaryocytic (M7) acute myeloid leukemia: case report. | Leukocyte adhesion deficiency type 1 (LAD 1 - CD18 deficiency) is a rare disease characterized by disturbance of phagocyte function associated with less severe cellular and humoral dysfunction. The main features are bacterial and fungal infections predominantly in the skin and mucosal surfaces, impaired wound healing a... | 25,106,692 | [
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Thioredoxin-1 redox signaling regulates cell survival in response to hyperoxia. | The most common form of newborn chronic lung disease, bronchopulmonary dysplasia (BPD), is thought to be caused by oxidative disruption of lung morphogenesis, which results in decreased pulmonary vasculature and alveolar simplification. Although cellular redox status is known to regulate cellular proliferation and diff... | 25,106,706 | [
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GP surgeons: what are they? An audit of GP surgeons in South Australia. | In many parts of Australia where there is no access to local specialist services, procedural services are provided by local GPs. Within the range of procedural skills offered, a small group of GPs is able to provide surgery. Unlike other procedural areas, there remains no defined training or assessment pathway for GP s... | 25,106,725 | [
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Neighborhood Ethnic Composition and Problem Drinking Among Older Mexican American Men: Results from the Hispanic Established Populations for the Epidemiologic Study of the Elderly. | Ethnic enclaves may be protective for health. This study investigates the effects of neighborhood co-ethnic density on problem drinking among older Mexican American men. Probability sample of 2,086 community-dwelling Mexican Americans aged 75 or older drawn in 2004-2005 residing in communities in Arizona, California, C... | 25,106,726 | [
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Preterm small-for-gestational age children: predictive role of gestational age for mental development at the age of 2 years. | The aim of the study was to compare the cognitive development of very low birth weight (VLBW) preterm SGA children and preterm AGA children at the age of 2 years. The hypothesis was that SGA children are at an additional risk for deficits in cognitive function. Additionally, the impact of neonatal risk factors and the ... | 25,106,733 | [
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Comprehensive study of hydrostatic pressure treated human umbilical cord blood cells via response surface method. | Amelioration of the survival parameters of cryopreserved samples after thawing has already been addressed through several techniques including vitrification to avoid the formation of ice cores. However, this approach cannot be followed in the case of samples with higher volumes. Hydrostatic pressure (HP) treatment has ... | 25,106,745 | [
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TDS exposure project: relevance of the total diet study approach for different groups of substances. | A method to validate the relevance of the Total Diet Study (TDS) approach for different types of substances is described. As a first step, a list of >2800 chemicals classified into eight main groups of relevance for food safety (natural components, environmental contaminants, substances intentionally added to foods,... | 25,106,751 | [
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Phylogenetic analyses on the diversity of Aspergillus fumigatus sensu lato based on five orthologous loci. | One hundred isolates of Aspergillus fumigatus sensu lato mainly from China, as well as from Australia, France, India, Indonesia, Ireland, UK, and USA were analyzed to infer their sequence types (STs) and population diversity based on partial calmodulin, calcineurin regulatory subunit B, beta-tubulin, cytochrome C and c... | 25,106,755 | [
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Role of Brønsted acid in selective production of furfural in biomass pyrolysis. | In this work, the role of Brønsted acid for furfural production in biomass pyrolysis on supported sulfates catalysts was investigated. The introduction of Brønsted acid was shown to improve the degradation of polysaccharides to intermediates for furfural, which did not work well when only Lewis acids were used in the p... | 25,106,779 | [
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Does an injection of a stromal vascular fraction containing adipose-derived mesenchymal stem cells influence the outcomes of marrow stimulation in osteochondral lesions of the talus? A clinical and magnetic resonance imaging study. | Marrow stimulation for the treatment of osteochondral lesions of the talus (OLTs) is controversial in patients with poor prognostic factors of OLTs. Currently, mesenchymal stem cells (MSCs) are expected to biologically augment the treatment of OLTs. To compare the clinical and magnetic resonance imaging (MRI) outcomes ... | 25,106,781 | [
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The effectiveness of student-run organizations within global health promotion initiatives. | This commentary describes a student-led project that distributed long-lasting insecticide-treated nets in Masaka, Uganda. The role of student-led initiatives in global health promotion projects is also discussed. A survey of 213 net recipients was conducted after a 12-month period to evaluate malaria prevention knowled... | 25,106,790 | [
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Natural polyphenols enhance stability of crosslinked UHMWPE for joint implants. | Radiation-crosslinked UHMWPE has been used for joint implants since the 1990s. Postirradiation remelting enhances oxidative stability, but with some loss in strength and toughness. Vitamin E-stabilized crosslinked UHMWPE has shown improved strength and stability as compared with irradiated and remelted UHMWPE. With mor... | 25,106,800 | [
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Positive symptoms and water diffusivity of the prefrontal and temporal cortices in schizophrenia patients: a pilot study. | The development of diffusion tensor imaging (DTI) has provided information about microstructural changes in the brain. Most DTI studies have focused on white matter (WM). Few DTI studies have examined the gray matter (GM) in schizophrenia and, to date, there has been no attempt to identify the relationship between wate... | 25,106,804 | [
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Unraveling the mechanism underlying the glycosylation and methylation of anthocyanins in peach. | Modification of anthocyanin plays an important role in increasing its stability in plants. Here, six anthocyanins were identified in peach (Prunus persica), and their structural diversity is attributed to glycosylation and methylation. Interestingly, peach is quite similar to the wild species Prunus ferganensis but dif... | 25,106,821 | [
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[Misuse of opioid analgesics. An internet analysis]. | Apart from the prescribed administration and indications for pain relief, opioids are also used for unintended purposes. Information for misuse is circulated on the internet. In order to analyze the abuse of opioids and opiates,which are only available by prescription, defined search keywords were entered into the sear... | 25,106,826 | [
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Is neutrophil/lymphocyte ratio predict to short-term mortality in acute cerebral infarct independently from infarct volume? | Neutrophil/lymphocyte ratio (NLR) is related with increased mortality in both myocardial infarction and acute ischemic stroke. It remains unclear whether NLR is a simple marker of ischemic infarct volume or an independent marker of stroke mortality. The aim of this study is to investigate the relationship of NLR with i... | 25,106,834 | [
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Metazoan parasite communities of catfishes (Teleostei: Siluridae) in Benin (West Africa). | The need for more precise information on the effect of dry season on fish parasite communities in Benin lead us to undergo a focus during this season in one of the major sites of collection fry by fish farmers.Metazoan parasites were then inventoried in 166 specimens of catfishes which constituted of C larias gariepinu... | 25,106,838 | [
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Age-dependent changes in Porphyromonas gingivalis and Prevotella species/phylotypes in healthy gingiva and inflamed/diseased sub-gingival sites. | Early colonisation of oral surfaces by periodontal pathogens presents a significant risk factor for subsequent development of destructive disease affecting tissues that support the dentition. The aims of the present study were to establish the age-dependent relationship between sub-gingival profiles of 22 Prevotella sp... | 25,106,846 | [
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Overexpression of recombinant infectious bursal disease virus (IBDV) capsid protein VP2 in the middle silk gland of transgenic silkworm. | Infectious bursal disease virus (IBDV) is the causative agent of a highly contagious disease affecting young chickens and causes serious economic losses to the poultry industry worldwide. Development of subunit vaccine using its major caspid protein, VP2, is one of the promising strategies to protect against IBDV. This... | 25,106,848 | [
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Stem-loop binding protein is required for retinal cell proliferation, neurogenesis, and intraretinal axon pathfinding in zebrafish. | In the developing retina, neurogenesis and cell differentiation are coupled with cell proliferation. However, molecular mechanisms that coordinate cell proliferation and differentiation are not fully understood. In this study, we found that retinal neurogenesis is severely delayed in the zebrafish stem-loop binding pro... | 25,106,852 | [
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The rice WUSCHEL-related homeobox genes are involved in reproductive organ development, hormone signaling and abiotic stress response. | The WUSCHEL-related homeobox (WOX) genes are important transcription regulators participated in plant development processes. Rice (Oryza sativa L.) genome encodes at least 13 WOX members. In this study, a systematic microarray-based gene expression profiling of eleven WOX genes was performed for the whole life cycle of... | 25,106,855 | [
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Drosophila COP9 signalosome subunit 7 interacts with multiple genomic loci to regulate development. | The COP9 signalosome protein complex has a central role in the regulation of development of multicellular organisms. While the function of this complex in ubiquitin-mediated protein degradation is well established, results over the past few years have hinted that the COP9 signalosome may function more broadly in the re... | 25,106,867 | [
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ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway. | Low-density lipoprotein receptor (LDLR) mRNA is unstable, but is stabilized upon extracellular signal-regulated kinase (ERK) activation, possibly through the binding of certain proteins to the LDLR mRNA 3'-untranslated region (UTR), although the detailed mechanism underlying this stability control is unclear. Here, usi... | 25,106,868 | [
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Quantification of DNA-associated proteins inside eukaryotic cells using single-molecule localization microscopy. | Development of single-molecule localization microscopy techniques has allowed nanometre scale localization accuracy inside cells, permitting the resolution of ultra-fine cell structure and the elucidation of crucial molecular mechanisms. Application of these methodologies to understanding processes underlying DNA repli... | 25,106,872 | [
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Lupinalbin A as the most potent estrogen receptor α- and aryl hydrocarbon receptor agonist in Eriosema laurentii de Wild. (Leguminosae). | Eriosema laurentii De Wild. (Leguminosae) is a plant used in Cameroon against infertility and gynecological or menopausal complaints. In our previous report, a methanol extract of its aerial parts was shown to exhibit estrogenic and aryl hydrocarbon receptor agonistic activities in vitro and to prevent menopausal sympt... | 25,106,881 | [
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Polymorphisms in endothelial nitric oxide synthase gene in early and late severe preeclampsia. | Preeclampsia (PE) is characterized by hypertension and proteinuria, occurring after the 20th week of pregnancy in women who have had no previous symptoms. The disease progresses with generalized vasoconstriction and endothelial dysfunction. Clinically, it is important to diagnose the severe form of the disease (sPE), i... | 25,106,888 | [
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Dynamic fabrication of tissue-engineered bone substitutes based on derived cancellous bone scaffold in a spinner flask bioreactor system. | The in vitro dynamic fabrications of tissue-engineered bones were performed to assess the advantages of human adipose-derived stem cells (hADSCs) combined with acellular cancellous bone scaffold coming from fresh pig femur in a spinner flask compared with traditional static culture. In this study, the bio-derived cance... | 25,106,897 | [
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CPP-mediated protein delivery in a noncovalent form: proof-of-concept for percutaneous and intranasal delivery. | Macromolecular drugs (e.g., proteins and nucleic acids) are highly environmentally liable and unstable, and their administration is strictly limited to injection. Moreover, a vast majority of macromolecules are cell membrane- impermeable, and it is a critical issue to enhance the cellular uptake efficiency for improvin... | 25,106,905 | [
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Desertibacter xinjiangensis sp. nov., isolated from the soil of a Euphrates poplar forest, and emended description of the genus Desertibacter. | A pale pink and strictly aerobic bacterium, designated strain M71(T), was isolated from the soil of a Euphrates poplar forest in Xingjiang, PR China. Cells of the strain were Gram-reaction-negative, rod-shaped and motile by means of a single polar flagellum. Growth occurred at 10-37 °C (optimum 30 °C), at pH 6.0-9.0 (o... | 25,106,921 | [
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De-identification of clinical narratives through writing complexity measures. | Electronic health records contain a substantial quantity of clinical narrative, which is increasingly reused for research purposes. To share data on a large scale and respect privacy, it is critical to remove patient identifiers. De-identification tools based on machine learning have been proposed; however, model train... | 25,106,934 | [
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Association of common SNP rs1136410 in PARP1 gene with the susceptibility to male infertility with oligospermia. | This study aims to explore possible associations between polymorphisms of common SNP rs1136410 and rS1805405 in PARP1 gene and male infertility with spermatogenesis impairment. The polymorphic distributions of SNP rs1136410 and rS1805405 were investigated by polymerase chain reaction and restriction fragment length pol... | 25,106,941 | [
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Subspecialty emergency room as alternative model for otolaryngologic care: implications for emergency health care delivery. | A dedicated otolaryngology emergency room (ER) represents a specialized surgical evaluation and treatment setting that may be an alternative triage pathway for acute otolaryngologic complaints. We aim to characterize practice patterns in this setting and to provide insight into the epidemiology of all-comer, urgent oto... | 25,106,951 | [
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Stability, complexity and robustness in population dynamics. | The problem of stability in population dynamics concerns many domains of application in demography, biology, mechanics and mathematics. The problem is highly generic and independent of the population considered (human, animals, molecules,…). We give in this paper some examples of population dynamics concerning nucleic ... | 25,107,273 | [
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Molecular pathogenesis of congenital diaphragmatic hernia revealed by exome sequencing, developmental data, and bioinformatics. | Congenital diaphragmatic hernia (CDH) is a common and severe birth defect. Despite its clinical significance, the genetic and developmental pathways underlying this disorder are incompletely understood. In this study, we report a catalog of variants detected by a whole exome sequencing study on 275 individuals with CDH... | 25,107,291 | [
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The mechanism of enterohepatic circulation in the formation of gallstone disease. | Bile acids entering into enterohepatic circulating are primary acids synthesized from cholesterol in hepatocyte. They are secreted actively across canalicular membrane and carried in bile to gallbladder, where they are concentrated during digestion. About 95% BAs are actively taken up from the lumen of terminal ileum e... | 25,107,305 | [
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Two C4-sterol methyl oxidases (Erg25) catalyse ergosterol intermediate demethylation and impact environmental stress adaptation in Aspergillus fumigatus. | The human pathogen Aspergillus fumigatus adapts to stress encountered in the mammalian host as part of its ability to cause disease. The transcription factor SrbA plays a significant role in this process by regulating genes involved in hypoxia and low-iron adaptation, antifungal drug responses and virulence. SrbA is a ... | 25,107,308 | [
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C-reactive protein and risk of fracture: a systematic review and dose-response meta-analysis of prospective cohort studies. | This study systematically reviews prospective cohort studies evaluating the relationship between C-reactive protein (CRP) concentrations and subsequent fracture risk. The positive association cannot completely explain the existing evidence, and further studies are needed to demonstrate the shape of the association. We ... | 25,107,320 | [
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Mechanical work and energy consumption in children with cerebral palsy after single-event multilevel surgery. | Multilevel surgery is commonly performed to improve walking in children with cerebral palsy (CP). Classical gait analysis (kinetics, kinematics) demonstrated positive outcomes after this intervention, however it doesn't give global indication about gait's features. The assessment of energy cost and mechanical work of l... | 25,107,323 | [
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[Maternal and perinatal outcomes in nulliparous gestations with late onset preeclampsia: Comparative study with gestations without preeclampsia]. | To assess obstetrical outcomes in a sample of nulliparous gestations with preeclampsia, as compared to gestations without preeclampsia, attended in the Enrique C. Sotomayor Hospital of Guayaquil, Ecuador. This was a comparative study of maternal and perinatal outcome data of gestations with late onset preeclampsia (n=1... | 25,107,334 | [
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Characteristics and outcomes of patients with multiple myeloma who develop therapy-related myelodysplastic syndrome, chronic myelomonocytic leukemia, or acute myeloid leukemia. | Patients with multiple myeloma (MM) have had significant improvements in outcomes. An increased risk of therapy-related myeloid neoplasms (t-MNs) has also developed. Little is known about the characteristics and outcomes of these patients. Patients with MM treated at our institution from 1993 to 2011 were reviewed. For... | 25,107,338 | [
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Use of multiplex PCR in diagnosis of bloodstream infections in kidney patients. | The LightCycler® SeptiFast Test (Roche Diagnostics GmbH, Mannheim, Germany) was prospectively compared with the standard blood culture technique in a series of 86 kidney patients. The sensitivity of the PCR compared with the culture was 71%, and the specificity was 88%. All the species identified by culture in these pa... | 25,107,361 | [
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CFTR interacts with ZO-1 to regulate tight junction assembly and epithelial differentiation through the ZONAB pathway. | Mutations in CFTR lead to dysfunction of tubular organs, which is currently attributed to impairment of its conductive properties. We now show that CFTR regulates tight junction assembly and epithelial cell differentiation through modulation of the ZO-1-ZONAB pathway. CFTR colocalizes with ZO-1 at the tight junctions o... | 25,107,366 | [
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Secreted fibroblast-derived miR-34a induces tubular cell apoptosis in fibrotic kidney. | Tubular epithelial cell apoptosis contributes to tubulointerstitial fibrosis but its regulation remains unclear. Here, in fibrotic kidney induced by unilateral ureteral obstruction (UUO), we demonstrate that miR-34a is markedly upregulated in tubulointerstitial spaces and microvesicles isolated from obstructed kidney. ... | 25,107,369 | [
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Natural products for the management of type 2 diabetes mellitus and comorbid conditions. | To provide pharmacists with practical information to guide consumers in their choices of herbal products and dietary supplements for the management of type 2 diabetes mellitus (T2DM) and its comorbid disease states. The herbal and dietary supplement market has grown exponentially over the past decade as Americans incre... | 25,107,389 | [
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Children's effortful control and academic achievement: do relational peer victimization and classroom participation operate as mediators? | Given that early academic achievement is related to numerous developmental outcomes, understanding processes that promote early success in school is important. This study was designed to clarify how students' (N=291; M age in fall of kindergarten=5.66 years, SD=0.39 year) effortful control, relational peer victimizatio... | 25,107,413 | [
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A review of paroxetine for the treatment of vasomotor symptoms. | Studies in recent years have exposed concerns about the safety of hormone replacement therapy (HRT) in the treatment of vasomotor symptoms (VMS) in menopausal women. Numerous studies have examined the use of antidepressants for relief of VMS. Despite recommendations to deny approval of paroxetine mesylate (Brisdelle™) ... | 25,107,421 | [
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Intrapleural Antimicrobial Irrigation for Postpneumonectomy Empyema in Patients With Lung Cancer. | Postpneumonectomy empyema (PPE) is a possible complication after a pneumonectomy in patients with lung cancer. The use of intrapleural (IP) antibiotic irrigation to treat infections in the pleural space may be indicated after systemic antimicrobial therapy, and drainage of the pleural space has been insufficient. Adult... | 25,107,425 | [
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Current and future use of point-of-care tests in primary care: an international survey in Australia, Belgium, The Netherlands, the UK and the USA. | Despite the growing number of point-of-care (POC) tests available, little research has assessed primary care clinician need for such tests. We therefore aimed to determine which POC tests they actually use or would like to use (if not currently available in their practice). Cross-sectional survey. Primary care in Austr... | 25,107,438 | [
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Phospholipid transfer protein in diabetes, metabolic syndrome and obesity. | It has been reported that phospholipid transfer protein (PLTP) is an independent risk factor for human coronary artery disease. And metabolic tissues are important contributors to the systemic pools of PLTP protein. Consistently, PLTP mass and activity have been found to be elevated in the plasma of type 2 diabetes mel... | 25,107,452 | [
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0.05810904,
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HepaRG microencapsulated spheroids in DMSO-free culture: novel culturing approaches for enhanced xenobiotic and biosynthetic metabolism. | The need for models that recapitulate liver physiology is perceived for drug development, study of liver disease and bioartificial liver support. The bipotent cell line HepaRG constitutes an efficient surrogate of liver function, yet its differentiated status relies on high concentrations of DMSO, which may compromise ... | 25,107,451 | [
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0.05994697,
0.1266817,
0.2200003,
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... |
Far lateral paracondylar versus transcondylar approach in the pediatric age group: CT morphometric analysis. | This study aimed to determine if partial removal of the occipital condyle provides a significant increase in visibility and "angle of attack" for treating lesions with extension ventral to the brainstem in children using CT morphometric data. Morphometric analysis was performed in 199 children using CT scans. Angle of ... | 25,107,454 | [
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Incidence and morbidity of craniocervical arterial dissections in atraumatic subarachnoid hemorrhage patients who underwent aneurysmal repair. | No studies have assessed the incidence of craniocervical arterial dissections (CCADs) and its association to mortality in hospitalized patients with a primary diagnosis of atraumatic subarachnoid hemorrhage (SAH) requiring aneurysmal repair. We hypothesize that the incidence of CCADs in these patients has increased ove... | 25,107,470 | [
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Akirin2 is critical for inducing inflammatory genes by bridging IκB-ζ and the SWI/SNF complex. | Transcription of inflammatory genes in innate immune cells is coordinately regulated by transcription factors, including NF-κB, and chromatin modifiers. However, it remains unclear how microbial sensing initiates chromatin remodeling. Here, we show that Akirin2, an evolutionarily conserved nuclear protein, bridges NF-κ... | 25,107,474 | [
0.246257,
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A new pathway for mitochondrial quality control: mitochondrial-derived vesicles. | The last decade has been marked by tremendous progress in our understanding of the cell biology of mitochondria, with the identification of molecules and mechanisms that regulate their fusion, fission, motility, and the architectural transitions within the inner membrane. More importantly, the manipulation of these mac... | 25,107,473 | [
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Glycemic control among U.S. Hispanics/Latinos with diabetes from the HCHS/SOL Sociocultural Ancillary Study: do structural and functional social support play a role? | Social support is one potential source of health-related resiliency in Hispanics with diabetes. This study examined relationships of structural (i.e., social integration) and functional (i.e., perceived) social support with glycemic control (glycosylated hemoglobin; HbA1c) in the Hispanic Community Health Study/Study o... | 25,107,503 | [
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Testing manifest monotonicity using order-constrained statistical inference. | Most dichotomous item response models share the assumption of latent monotonicity, which states that the probability of a positive response to an item is a nondecreasing function of a latent variable intended to be measured. Latent monotonicity cannot be evaluated directly, but it implies manifest monotonicity across a... | 25,107,519 | [
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Optimal and most exact confidence intervals for person parameters in item response theory models. | The common way to calculate confidence intervals for item response theory models is to assume that the standardized maximum likelihood estimator for the person parameter θ is normally distributed. However, this approximation is often inadequate for short and medium test lengths. As a result, the coverage probabilities ... | 25,107,520 | [
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Surface texture and priming play important roles in predator recognition by the red-backed shrike in field experiments. | We compared the responses of the nesting red-backed shrikes (Lanius collurio) to three dummies of a common nest predator, the Eurasian jay (Garrulus glandarius), each made from a different material (stuffed, plush, and silicone). The shrikes performed defensive behaviour including attacks on all three dummies. Neverthe... | 25,107,529 | [
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MAGE proteins regulate KRAB zinc finger transcription factors and KAP1 E3 ligase activity. | Expression of Melanoma AntiGen Encoding (MAGE) genes, particularly MAGE-A3, has been correlated with aggressive clinical course, the acquisition of resistance to chemotherapy and poor clinical outcomes of melanoma and other malignancies. MAGE proteins bind to KAP1, a gene repressor and ubiquitin E3 ligase which also bi... | 25,107,531 | [
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The role of CXC chemokine receptor 2 in Staphylococcus aureus keratitis. | Staphylococcus aureus is a leading cause of corneal infection. CXC receptor 2 binding chemokines have been implicated in the pathogenesis of Pseudomonas aeruginosa keratitis. The role of this receptor in immune responses during Staphylococcus keratitis remains to be fully understood. Corneas of CXC receptor 2 knockout ... | 25,107,538 | [
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Activation of β-catenin signalling by TFF1 loss promotes cell proliferation and gastric tumorigenesis. | In this study, we investigated the role of Trefoil factor 1 (TFF1) in regulating cell proliferation and tumour development through β-catenin signalling using in vivo and in vitro models of gastric tumorigenesis. Tff1-knockout (Tff1-KO) mice, immunohistochemistry, luciferase reporter, qRT-PCR, immunoblot, and phosphatas... | 25,107,557 | [
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The rescuable function and mechanism of resveratrol on As₂O₃-induced hERG K⁺ channel deficiency. | Arsenic trioxide (As2O3) is used to treat acute promyelocytic leukemia. However, the cardiotoxicity of long QT syndrome restricts its clinical application. Previous studies showed that As2O3 can damage the human ether-a-go-go-related gene (hERG) current via disturbing its trafficking to cellular membrane. This study ai... | 25,107,562 | [
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Phase II gemcitabine and capecitabine combination therapy in recurrent or metastatic breast cancer patients pretreated with anthracycline and taxane. | We conducted a phase II study evaluating safety and efficacy of combination gemcitabine and capecitabine therapy for metastatic breast cancer patients following anthracycline and taxane treatment in Korea. This was a single-arm, non-randomized phase II study. Patients received 1,000 mg/m(2) gemcitabine intravenously ov... | 25,107,569 | [
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Anticancer activity of VDR-coregulator inhibitor PS121912. | PS121912 has been developed as selective vitamin D receptor (VDR)-coregulator inhibitor starting from a high throughput screening campaign to identify new agents that modulate VDR without causing hypercalcemia. Initial antiproliferative effects of PS121912 were observed that are characterized herein to enable future in... | 25,107,568 | [
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Family history as a risk factor for peripheral arterial disease. | The association of a family history of peripheral arterial disease (PAD) with the presence of PAD is largely unknown. We conducted a case-control study of 2,296 patients with PAD (69 ± 10 years, 64% men) and 4,390 controls (66 ± 11 years, 62% men) identified from noninvasive vascular and stress testing laboratories at ... | 25,107,577 | [
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Erythrocyte very long-chain saturated fatty acids associated with lower risk of incident sudden cardiac arrest. | Prior studies suggest that circulating n-3 and trans-fatty acids influence the risk of sudden cardiac arrest (SCA). Yet, while other fatty acids also differ in their membrane properties and biological activities which may influence SCA, little is known about the associations of other circulating fatty acids with SCA. T... | 25,107,579 | [
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Leishmania molecules that mediate intracellular pathogenesis. | Parasites of the Leishmania genus are the causative agents of a complex disease called leishmaniasis. Many activities of infected cells including their responses to a range of stimuli are modulated by Leishmania parasites. This review will profile some of the parasite molecules that target host cell processes for which... | 25,107,580 | [
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Vascular access in hemodialysis patients older than 80 years. | There is a worldwide surge in numbers of elderly people requiring hemodialysis accompanying the prevailing increase in longevity. There is a trend for central venous catheters to be preferentially placed in elderly patients, whereas others recommend routine use of grafts for surgical access. In our center, age has not ... | 25,107,601 | [
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Clinical manifestations and prognostic factors of Morganella morganii bacteremia. | Although Morganella morganii causes a variety of clinical infections, there are limited studies on M. morganii bacteremia after the year 2000. A total of 109 patients with M. morganii bacteremia at a medical center in Taiwan from 2003 to 2012 were studied. Among them, 30.3 % had polymicrobial bacteremia and 75.2 % had ... | 25,107,625 | [
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Photo-oxidation of tyrosine in a bio-engineered bacterioferritin 'reaction centre'-a protein model for artificial photosynthesis. | The photosynthetic reaction centre (RC) is central to the conversion of solar energy into chemical energy and is a model for bio-mimetic engineering approaches to this end. We describe bio-engineering of a Photosystem II (PSII) RC inspired peptide model, building on our earlier studies. A non-photosynthetic haem contai... | 25,107,631 | [
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Coverage of vitamin A supplementation and deworming during Malezi Bora in Kenya. | Twice-yearly child health weeks are an effective way of reaching children with essential child survival services in developing countries. In Kenya, child health weeks, or Malezi Bora, were restructured in 2007 from an outreach-based delivery structure to a health facility-based delivery structure to reduce delivery cos... | 25,107,652 | [
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Low-contrast response deficits and increased neural noise in children with autism spectrum disorder. | A battery of short-duration neurophysiological tests were designed and implemented using visual evoked potentials (VEPs) to examine specific neural mechanisms in children with and without autism spectrum disorder (ASD). Contrast-sweep conditions (bright or dark isolated-checks) were used to elicit steady-state VEPs to ... | 25,107,679 | [
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Prevalence and neuro-psychiatric comorbidities of pediatric epilepsy in Taiwan: a national population-based study. | Children with epilepsy may have comorbidities that result in significant disability. Epidemiological information for pediatric patients with epilepsy in Taiwan is scant. This research estimates the prevalence and common neuro-psychiatric comorbidities of children with epilepsy in Taiwan. Patients aged less than 20 year... | 25,107,685 | [
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MCL-1 dependency of cisplatin-resistant cancer cells. | The selection of human cancer cell lines in cis-diamminedichloroplatinum(II) (CDDP, best known as cisplatin) is accompanied by stereotyped alterations that contribute to the acquisition of a CDDP-resistant state. Thus, CDDP resistance often leads to the upregulation of the DNA repair enzyme poly (ADP-ribose) polymerase... | 25,107,702 | [
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The impact of intraoperative hypothermia on early postoperative adverse events after radical esophagectomy for cancer: a retrospective cohort study. | To investigate the correlation between intraoperative body temperature and postoperative adverse effects in patients who underwent esophagectomy procedures. Retrospective cohort study. University Hospital. One hundred twenty-one patients undergoing esophagectomy were enrolled. None. Various perioperative and intraopera... | 25,107,714 | [
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Time up and go task performance improves after transcranial direct current stimulation in patient affected by Parkinson's disease. | Locomotor disturbances represent one of the major distress in everyday life in people with Parkinson's disease (PD). Timed up and go test (TUG) has been advocated a useful and reliable tool for quantifying locomotor performance. The aim of this study was to assess the effect of anodal transcranial direct current stimul... | 25,107,738 | [
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Prognostic factors and course for successful clinical outcome quality of life and patients' perceived effect after a cognitive behavior therapy for chronic non-specific low back pain: A 12-months prospective study. | This study investigates the clinical course of and prognostic factors for quality of life (Short Form 36 items Health survey (SF-36)) and global perceived effect (GPE) in patients treated for chronic non-specific low back pain at 5 and 12-months follow-up. Data from a prospective cohort (n = 1760) of a rehabilitation c... | 25,107,827 | [
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Delivery of lipophilic porphyrin by liposome vehicles: preparation and photodynamic therapy activity against cancer cell lines. | Porphyrin photosensitizers are mostly used components in photodynamic therapy (PDT). The poor solubility of porphyrins in aqueous medium is the problem to be solved for the in vivo applications. The delivery of photosensitizers to the tumor cells using liposome vehicles can help to overcome this problem. In this work, ... | 25,107,838 | [
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(19)F applications in drug development and imaging - a review. | To control drugs in vivo, new approaches are needed. Considerable progress has been made towards the applications of fluorine ((19)F) in pharmacotherapy in this regard. To date, many authors have showed that by using (19)F labelled drugs and non-invasive magnetic resonance imaging (MRI) techniques together, drug biodis... | 25,107,839 | [
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IκB kinase β (IKBKB) mutations in lymphomas that constitutively activate canonical nuclear factor κB (NFκB) signaling. | Somatic mutations altering lysine 171 of the IKBKB gene that encodes (IKKβ), the critical activating kinase in canonical (NFκB) signaling, have been described in splenic marginal zone lymphomas and multiple myeloma. Lysine 171 forms part of a cationic pocket that interacts with the activation loop phosphate in the acti... | 25,107,905 | [
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-0.01186412,
0.05749775,
0.5260265,
0.2542707,
0.002617736,
... |
A novel mouse model of a patient mucolipidosis II mutation recapitulates disease pathology. | Mucolipidosis II (MLII) is a lysosomal storage disorder caused by loss of N-acetylglucosamine-1-phosphotransferase, which tags lysosomal enzymes with a mannose 6-phosphate marker for transport to the lysosome. In MLII, the loss of this marker leads to deficiency of multiple enzymes and non-enzymatic proteins in the lys... | 25,107,912 | [
-0.3049288,
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0.1363824,
0.2758792,
0.2665249,
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... |
Molecular pathways: linking tumor microenvironment to epithelial-mesenchymal transition in metastasis. | During tumor development, tumor cells constantly communicate with the surrounding microenvironment through both biochemical and biophysical cues. In particular, the tumor microenvironment can instruct carcinoma cells to undergo a morphogenesis program termed epithelial-to-mesenchymal transition (EMT) to facilitate loca... | 25,107,915 | [
0.04018537,
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0.1618062,
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0.... |
Membrane dynamics at the nuclear exchange junction during early mating (one to four hours) in the ciliate Tetrahymena thermophila. | Using serial-section transmission electron microscopy and three-dimensional (3D) electron tomography, we characterized membrane dynamics that accompany the construction of a nuclear exchange junction between mating cells in the ciliate Tetrahymena thermophila. Our methods revealed a number of previously unknown feature... | 25,107,923 | [
-0.2303676,
0.08696211,
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0.03729816,
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0.2674022,
0.5184205,
-0.05755454,... |
Alport syndrome: its effects on the glomerular filtration barrier and implications for future treatment. | The glomerular filtration barrier comprises a fenestrated capillary endothelium, glomerular basement membrane and podocyte slit diaphragm. Over the past decade we have come to realise that permselectivity depends on size and not necessarily charge, that the molecular sieve depends on the podocyte contractile apparatus ... | 25,107,927 | [
-0.008726728,
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-0.003675951,
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0.08740304,
-0.6023254,
0.0622914,
-0.001645426,
-0.06081886,
-0... |
Different effects of transgenic maize and nontransgenic maize on nitrogen-transforming archaea and bacteria in tropical soils. | The composition of the rhizosphere microbiome is a result of interactions between plant roots, soil, and environmental conditions. The impact of genetic variation in plant species on the composition of the root-associated microbiota remains poorly understood. This study assessed the abundances and structures of nitroge... | 25,107,970 | [
0.1431987,
0.146221,
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0.21876,
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0.2868973,
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0.5078138,
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Vibrio harveyi adheres to and penetrates tissues of the European abalone Haliotis tuberculata within the first hours of contact. | Vibrio harveyi is a marine bacterial pathogen responsible for episodic epidemics generally associated with massive mortalities in many marine organisms, including the European abalone Haliotis tuberculata. The aim of this study was to identify the portal of entry and the dynamics of infection of V. harveyi in the Europ... | 25,107,972 | [
0.08990927,
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0.2832884,
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0.1134429,
0.6760848,
0.3075951,
0.099089,
... |
Obesity and physical activity in children of immigrants. | Childhood overweight and obesity have increased in recent decades, reaching alarming proportions. Children with a migrant background seem to be particularly at risk of developing overweight and obesity. This article provides an overview of the prevalence of overweight or obesity among North African (NA) children living... | 25,107,997 | [
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0.1813397,
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0.5356534,
-0.2576206,
-0.1283777,
-0.04307926,
0.2058563,
-0.3950765... |
Consanguinity and genetic diseases in North Africa and immigrants to Europe. | Endemic diseases are caused by environmental and genetic factors. While in this special issue several chapters deal with environmental factors, including infections, the present focus is on genetic causes of disease clustering due to inbreeding and recessive disease mechanisms. Consanguinity is implying sharing of gene... | 25,107,999 | [
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0.06097376,
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0.04992984,
0.1973689,
0.2895846,
-0.1... |
Metabolic hyperemia requires ATP-sensitive K+ channels and H2O2 but not adenosine in isolated mouse hearts. | We have previously demonstrated that adenosine-mediated H2O2 production and opening of ATP-sensitive K(+) (KATP) channels contributes to coronary reactive hyperemia. The present study aimed to investigate the roles of adenosine, H2O2, and KATP channels in coronary metabolic hyperemia (MH). Experiments were conducted on... | 25,108,010 | [
-0.1402565,
-0.2828934,
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0.1723087,
0.2713482,
0.2956339,
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0.0420423,
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0.1350673,
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0.2558237,
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0.1049308,
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0.1850219,
0.2152795,
-0.1550532,
-0... |
Role of blood and vascular smooth muscle in the vasoactivity of nitrite. | Recent evidence from humans and rats indicates that nitrite is a vasodilator under hypoxic conditions by reacting with metal-containing proteins to produce nitric oxide (NO). We tested the hypothesis that near-physiological concentrations of nitrite would produce vasodilation in a hypoxia- and concentration-dependent m... | 25,108,012 | [
-0.2560561,
0.0480939,
-0.5815629,
0.1247874,
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-0.2981007,
0.05413772,
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0.1763641,
-0.1762953,
0.3176512,
0.02658554... |
Thymic epithelium determines a spontaneous chronic neuritis in Icam1(tm1Jcgr)NOD mice. | The NOD mouse strain spontaneously develops autoimmune diabetes. A deficiency in costimulatory molecules, such as B7-2, on the NOD genetic background prevents diabetes but instead triggers an inflammatory peripheral neuropathy. This constitutes a shift in the target of autoimmunity, but the underlying mechanism remains... | 25,108,020 | [
-0.09421816,
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0.06501953,
-0.04797531,
0.4245181,
0.2664975,
... |
In vitro PAMAM, phosphorus and viologen-phosphorus dendrimers prevent rotenone-induced cell damage. | We have investigated whether polyamidoamine (PAMAM), phosphorus (pd) and viologen-phosphorus (vpd) dendrimers can prevent damage to embryonic mouse hippocampal cells (mHippoE-18) caused by rotenone, which is used as a pesticide, insecticide, and as a nonselective piscicide, that works by interfering with the electron t... | 25,108,046 | [
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0.06231246,
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0.07897211,
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0.03917484,
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0.2652062,
0.1080037,
0.102808,
0.1380774,
0.2578419,
0.1563394,
... |
Cardiovascular and autonomic responses to whole-body cryostimulation in essential hypertension. | Over recent years, a considerable increase in the popularity of cryostimulation and whole body cryotherapy (WBC) procedures has occurred both among healthy individuals and in various groups of patients, including those with primary untreated hypertension. The aim of this study was to compare the effects of WBC on the f... | 25,108,050 | [
-0.1496659,
0.1945259,
-0.4306454,
0.1119037,
0.03187878,
-0.5978009,
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0.08215525,
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0.1762069,
-0.3029234,
0.3317901,
-0.1769474,... |
A critical appraisal of existing concepts for the grouping of nanomaterials. | The grouping of substances serves to streamline testing for regulatory purposes. General grouping approaches for chemicals have been implemented in, e.g., the EU chemicals regulation. While specific regulatory frameworks for the grouping of nanomaterials are unavailable, this topic is addressed in different publication... | 25,108,058 | [
-0.3506684,
0.2104104,
0.05166952,
0.09347914,
0.1208557,
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0.1168615,
0.1413776,
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0.2093138,
0.01293305,
0.04295504,
0.2452343,
0.4610416,
0.004481736,
... |
Localization of ocular albinism-1 gene product GPR143 in the rat central nervous system. | L-3,4-Dihydroxyphenylalanine (DOPA) has been believed to be a precursor of dopamine, and itself being an inert amino acid. Previously, we have proposed DOPA as a neurotransmitter candidate in the central nervous system (CNS). Recent findings have suggested DOPA as an endogenous agonist of a G-protein coupled receptor, ... | 25,108,060 | [
0.1852299,
-0.4007262,
-0.07435475,
-0.2167366,
-0.03208997,
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0.02670369,
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0.1482629,
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0.224507,
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0.2213809,
0.2022083,
0.008166292,
-0.04709923,
0.3135844,
-0.01514929... |
Progesterone production is affected by unfolded protein response (UPR) signaling during the luteal phase in mice. | We examined whether the three unfolded protein response (UPR) signaling pathways, which are activated in response to endoplasmic reticulum (ER)-stress, are involved in progesterone production in the luteal cells of the corpus luteum (CL) during the mouse estrous cycle. The luteal phase of C57BL/6 female mice (8 weeks o... | 25,108,065 | [
0.007656185,
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0.04157019,
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0.3553322,
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0.3468655,
0.04622739,
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0.06248066,
0.2432322,
0.06150448,
0.005750647,
0.228036,
0.3249877,
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0... |
Synthesis and biological evaluations of new analogs of 2-methoxyestradiol: inhibitors of tubulin and angiogenesis. | The synthesis, cytotoxicity, inhibition of tubulin polymerization and anti-angiogenic effects of 15 analogs of 2-methoxyestradiol (1) are reported. The biological studies revealed that the position of nitrogen atom in the heterocyclic ring is important for inhibition of both tubulin polymerization and angiogenesis. The... | 25,108,078 | [
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0.5157014,
0.02861474,
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0.06930444,
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0.3313656,
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0.3002185,
0.4285843,
0.3197874,
-0.194161... |
Synthesis and biological evaluation of novel thieno[2,3-d]pyrimidine-based FLT3 inhibitors as anti-leukemic agents. | The most common mutations in acute myeloid leukemia (AML) are those that cause the activation of FMS-like tyrosine kinase 3 (FLT3). Therefore, FLT3 is regarded as a potential target for the treatment of AML. A novel series of thieno[2,3-d]pyrimidine-based analogs was designed and synthesized as FLT3 inhibitors. All syn... | 25,108,079 | [
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0.3223054,
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0.2611367,
-0.2980722,
0.3559082,
0.4116923,
0.4727895,
-0.2265292,
0... |
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