title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Intra-amniotic LPS modulates expression of antimicrobial peptides in the fetal sheep lung. | Damage-associated molecular patterns (DAMPs) and antimicrobial peptides (AMPs) are components of pulmonary innate immunity and tissue repair. We hypothesized that DAMPs and AMPs would increase in response to fetal pulmonary inflammation caused by chorioamnionitis in a time-dependent manner. Fetal sheep were exposed to ... | 25,105,257 | [
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Hereditary interstitial lung diseases manifesting in early childhood in Japan. | Genetic variations associated with interstitial lung diseases (ILD) have not been extensively studied in Japanese infants. Forty-three infants with unexplained lung dysfunction were studied. All 43, 22, and 17 infants underwent analyses of surfactant protein (SP)-C gene (SFTPC) and ATP-binding cassette A3 gene (ABCA3),... | 25,105,258 | [
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The heat-transfer method: a versatile low-cost, label-free, fast, and user-friendly readout platform for biosensor applications. | In recent years, biosensors have become increasingly important in various scientific domains including medicine, biology, and pharmacology, resulting in an increased demand for fast and effective readout techniques. In this Spotlight on Applications, we report on the recently developed heat-transfer method (HTM) and il... | 25,105,260 | [
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Effect of multidisciplinary disease management for hospitalized heart failure under a national health insurance programme. | Multidisciplinary disease management programmes (MDPs) for heart failure have been shown to be effective in Western countries. However, it is not known whether they improve outcomes in a high population density country with a national health insurance programme. In total, 349 patients hospitalized because of heart fail... | 25,105,284 | [
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Lapatinib antagonizes multidrug resistance-associated protein 1-mediated multidrug resistance by inhibiting its transport function. | Lapatinib, a tyrosine kinase inhibitor, is used in the treatment of advanced or metastatic breast cancer overexpressing human epidermal receptor 2 (HER2). Lapatinib can modulate the function of ATP-binding cassette (ABC) transporters (ABCB1 and ABCG2), which are the major mechanism responsible for multidrug resistance ... | 25,105,301 | [
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Comparative effectiveness of second-line targeted therapies for metastatic renal cell carcinoma: synthesis of findings from two multi-practice chart reviews in the United States. | Second-line targeted therapies for metastatic renal cell carcinoma (mRCC) include mammalian target of rapamycin (mTOR) inhibitors and tyrosine kinase inhibitors (TKIs). This study compares the effectiveness of these therapies in a multi-practice chart review and synthesizes the findings with those of a similarly design... | 25,105,304 | [
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Cell death and DAMPs in acute pancreatitis. | Cell death and inflammation are key pathologic responses of acute pancreatitis (AP), the leading cause of hospital admissions for gastrointestinal disorders. It is becoming increasingly clear that damage-associated molecular pattern molecules (DAMPs) play an important role in the pathogenesis of AP by linking local tis... | 25,105,302 | [
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Treatment preference, adherence and outcomes in patients with cancer: literature review and development of a theoretical model. | A patient's preference may guide their behavior and influence their willingness to take medication or undergo treatment affecting outcomes, such as health-related quality of life, or survival. The importance of understanding patient preferences within oncology is unclear and few adherence studies exist compared with ot... | 25,105,306 | [
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Intravitreal ranibizumab injections with and without pneumatic displacement for treating submacular hemorrhage secondary to neovascular age-related macular degeneration. | To evaluate the efficacy of intravitreal ranibizumab with and without pneumatic displacement for the treatment of submacular hemorrhage secondary to neovascular age-related macular degeneration. We retrospectively reviewed the medical records of 93 treatment-naive patients (93 eyes) with submacular hemorrhage secondary... | 25,105,310 | [
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Expansion of the CRISPR-Cas9 genome targeting space through the use of H1 promoter-expressed guide RNAs. | The repurposed CRISPR-Cas9 system has recently emerged as a revolutionary genome-editing tool. Here we report a modification in the expression of the guide RNA (gRNA) required for targeting that greatly expands the targetable genome. gRNA expression through the commonly used U6 promoter requires a guanosine nucleotide ... | 25,105,359 | [
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What is the risk of diagnostic endoscopic retrograde cholangiopancreatography before cholecystectomy? | Many surgeons prefer to perform endoscopic retrograde cholangiopancreatography (ERCP) before cholecystectomy, specifically in patients at significant risk of having biliary pathology. However, a preoperative diagnostic ERCP, without the use of an endoscopic ultrasound or magnetic retrograde cholangiopancreatoscopy, rem... | 25,105,391 | [
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Reassessment of the role of enteral tube feedings for patients with esophageal cancer. | Nutrition is important for patients with esophageal cancer because dysphagia can be exacerbated by chemoradiotherapy. Some centers suggest routine enteral tube placement (TF) to facilitate nutrition. This investigation was to evaluate the use of TF access for patients undergoing multimodality therapy for esophageal car... | 25,105,392 | [
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Program directors' perspective of transplant training during general surgery residency. | In 2011, the Accreditation Council for Graduate Medical Education (ACGME) began to mandate "a formal transplant experience" rather than a formal rotation to allow programs more flexibility. What constitutes a "transplant experience" or how to optimize such education remains unclear. The objectives of this study were to... | 25,105,401 | [
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Hinokitiol induces DNA damage and autophagy followed by cell cycle arrest and senescence in gefitinib-resistant lung adenocarcinoma cells. | Despite good initial responses, drug resistance and disease recurrence remain major issues for lung adenocarcinoma patients with epidermal growth factor receptor (EGFR) mutations taking EGFR-tyrosine kinase inhibitors (TKI). To discover new strategies to overcome this issue, we investigated 40 essential oils from plant... | 25,105,411 | [
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MicroRNA-493 suppresses tumor growth, invasion and metastasis of lung cancer by regulating E2F1. | miRNAs have been proposed to be key regulators of progression and metastasis in cancer. However, an understanding of their roles and molecular mechanisms is needed to provide deeper insights for better therapeutic opportunities. In this study we investigated the role and mechanism of miR-493 in the development and prog... | 25,105,419 | [
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[From psychopathophysiology towards a biomarker-based classification and stratified treatment of schizophrenic disorders]. | This article gives an overview of the role of functional neuroimaging for 1. a better understanding of the phenotypic symptoms and their underlying pathophysiology, 2. research into the genetic and environmental factors involved in the pathogenesis, and 3. current and future developments towards a biomarker-based class... | 25,105,430 | [
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Unique effects of the chain lengths and anions of tetra-alkylammonium salts on quenching pyrene excimer. | Pyrene (Py) excimer, through its unique fluorescence quenching, exhibits high sensitivity and high selectivity in detecting specific electron-deficient molecules, providing a potential platform for sensing technology, optical switch, and probing hydrophobicity of molecular environment. In solution state, its quenching ... | 25,105,459 | [
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Supertough polylactide materials prepared through in situ reactive blending with PEG-based diacrylate monomer. | Supertough biocompatible and biodegradable polylactide materials were fabricated by applying a novel and facile method involving reactive blending of polylactide (PLA) and poly(ethylene glycol) diacylate (PEGDA) monomer with no addition of exogenous radical initiators. Torque analysis and FT-IR spectra confirm that cro... | 25,105,468 | [
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Phylogeography and epidemic history of hepatitis C virus genotype 4 in Africa. | HCV genotype 4 is prevalent in many African countries, yet little is known about the genotype׳s epidemic history on the continent. We present a comprehensive study of the molecular epidemiology of genotype 4. To address the deficit of data from the Democratic Republic of the Congo (DRC) we PCR amplified 60 new HCV isol... | 25,105,489 | [
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Response of Saccharomyces cerevisiae to the stimulation of lipopolysaccharide. | Lipopolysaccharide, known as endotoxin, can stimulate potent host immune responses through the complex of Toll-like-receptor 4 and myeloid differentiation protein 2; but its influence on Saccharomyces cerevisiae, a model organism for studying eukaryotes, is not clear. In this study, we found that lipopolysaccharide-tre... | 25,105,496 | [
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Systemic CD8+ T cell-mediated tumoricidal effects by intratumoral treatment of oncolytic herpes simplex virus with the agonistic monoclonal antibody for murine glucocorticoid-induced tumor necrosis factor receptor. | Oncolytic virotherapy combined with immunomodulators is a novel noninvasive strategy for cancer treatment. In this study, we examined the tumoricidal effects of oncolytic HF10, a naturally occurring mutant of herpes simplex virus type-1, combined with an agonistic DTA-1 monoclonal antibody specific for the glucocortico... | 25,105,508 | [
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Enantioselective carbocycle formation through intramolecular Pd-catalyzed allyl-aryl cross-coupling. | Aryl electrophiles containing tethered allylboronate units undergo efficient intramolecular coupling in the presence of a chiral palladium catalyst to give enantioenriched carbocyclic products. The reaction is found to be quite general, affording 5, 6, and 7-membered carbocyclic products as single regioisomers and with... | 25,105,510 | [
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What is the risk of infecting a cerebrospinal fluid-diverting shunt with percutaneous tapping? | Most CSF-diverting shunt systems have an access port that can be percutaneously tapped. Tapping the shunt can yield valuable information as to its function and whether an infection is present. The fear of causing a shunt infection by tapping may limit the physician's willingness to do so. The authors of this study inve... | 25,105,511 | [
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Elastic nature of the lacrimal canalicular wall. | To examine the elastic nature of the lacrimal canalicular wall. Fifteen postmortem specimens of 11 Japanese individuals (8 right, 7 left; age range, 45-89 years at death) fixed in 10% buffered formalin were axially sliced parallel to the lower eyelid margin to include all 3 portions of the lacrimal canaliculi (intrasac... | 25,105,525 | [
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Shear adhesion strength of aligned electrospun nanofibers. | Inspiration from nature such as insects' foot hairs motivates scientists to fabricate nanoscale cylindrical solids that allow tens of millions of contact points per unit area with material substrates. In this paper, we present a simple yet robust method for fabricating directionally sensitive shear adhesive laminates. ... | 25,105,533 | [
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Oleic acid-induced hepatic steatosis is coupled with downregulation of aquaporin 3 and upregulation of aquaporin 9 via activation of p38 signaling. | Excess lipid deposition in hepatocytes is a hallmark feature of nonalcoholic fatty liver disease (NAFLD). The present study was designed to explore the expression and regulation of aquaporin (AQP) 3 and AQP9 in oleic acid-induced hepatic steatosis. HepG2 cells were incubated with oleic acid at different concentrations ... | 25,105,540 | [
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Comparison of clinical management of young and elderly asthmatics by respiratory specialists and general practitioners. | Asthmatic death in the elderly is a serious problem worldwide. Differences in clinical skill between respiratory specialists (RS) and general practitioners (GP) are important in asthma control. The aim of this study was to compare asthma management between RS and GP. A cross-sectional survey was carried out in Shimane,... | 25,105,556 | [
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The diagnostic adaptive behavior scale: evaluating its diagnostic sensitivity and specificity. | The Diagnostic Adaptive Behavior Scale (DABS) was constructed with items across three domains--conceptual, social, and practical adaptive skills--and normed on a representative sample of American individuals from 4 to 21 years of age. The DABS was developed to focus its assessment around the decision point for determin... | 25,105,569 | [
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Out of the F-box: reawakening the pancreas. | The adult pancreas lacks stem cells, and consequently, differentiation of pancreatic endocrine cells has been restricted to embryonic development or experimental manipulation. In this issue of Cell Stem Cell, Sancho et al. (2014) show that pancreas-specific loss of the ubiquitin ligase Fbxw7 stabilizes an endocrine-spe... | 25,105,572 | [
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Loss of Fbw7 reprograms adult pancreatic ductal cells into α, δ, and β cells. | The adult pancreas is capable of limited regeneration after injury but has no defined stem cell population. The cell types and molecular signals that govern the production of new pancreatic tissue are not well understood. Here, we show that inactivation of the SCF-type E3 ubiquitin ligase substrate recognition componen... | 25,105,579 | [
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Nanoporous silicon nitride membranes fabricated from porous nanocrystalline silicon templates. | The extraordinary permeability and manufacturability of ultrathin silicon-based membranes are enabling devices with improved performance and smaller sizes in such important areas as molecular filtration and sensing, cell culture, electroosmotic pumping, and hemodialysis. Because of the robust chemical and mechanical pr... | 25,105,590 | [
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Phototoxic effect of na-pheophorbide a toward osteosarcoma cells in vitro using a laser diode. | The purpose of this study was to investigate the effectiveness of photodynamic therapy (PDT) with Na-pheophorbide A in anticancer treatment, using osteosarcoma cells in vitro. It has been reported that PDT with chlorophyll derivatives inhibits the proliferation of various cancer cells. However, there have been no repor... | 25,105,597 | [
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Experimental comparison of efficient tomography schemes for a six-qubit state. | Quantum state tomography suffers from the measurement effort increasing exponentially with the number of qubits. Here, we demonstrate permutationally invariant tomography for which, contrary to conventional tomography, all resources scale polynomially with the number of qubits both in terms of the measurement effort as... | 25,105,604 | [
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Antineutrino monitoring for heavy water reactors. | In this Letter we discuss the potential application of antineutrino monitoring to the Iranian heavy water reactor at Arak, the IR-40, as a nonproliferation measure. An above ground detector positioned right outside the IR-40 reactor building could meet IAEA verification goals for reactor plutonium inventories. While de... | 25,105,612 | [
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Spin and valley noise in two-dimensional Dirac materials. | We develop a theory for optical Faraday rotation noise in two-dimensional Dirac materials. In contrast to spin noise in conventional semiconductors, we find that the Faraday rotation fluctuations are influenced not only by spins but also the valley degrees of freedom attributed to intervalley scattering processes. We i... | 25,105,640 | [
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Characterization of spin-orbit interactions of GaAs heavy holes using a quantum point contact. | We present transport experiments performed in high-quality quantum point contacts embedded in a GaAs two-dimensional hole gas. The strong spin-orbit interaction results in peculiar transport phenomena, including the previously observed anisotropic Zeeman splitting and level-dependent effective g factors. Here we find a... | 25,105,641 | [
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Fractional quantum Hall effect in a curved space: gravitational anomaly and electromagnetic response. | We develop a general method to compute correlation functions of fractional quantum Hall (FQH) states on a curved space. In a curved space, local transformation properties of FQH states are examined through local geometric variations, which are essentially governed by the gravitational anomaly. Furthermore, we show that... | 25,105,643 | [
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Superradiant decay of cyclotron resonance of two-dimensional electron gases. | We report on the observation of collective radiative decay, or superradiance, of cyclotron resonance (CR) in high-mobility two-dimensional electron gases in GaAs quantum wells using time-domain terahertz magnetospectroscopy. The decay rate of coherent CR oscillations increases linearly with the electron density in a wi... | 25,105,654 | [
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Active phase and amplitude fluctuations of flagellar beating. | The eukaryotic flagellum beats periodically, driven by the oscillatory dynamics of molecular motors, to propel cells and pump fluids. Small but perceivable fluctuations in the beat of individual flagella have physiological implications for synchronization in collections of flagella as well as for hydrodynamic interacti... | 25,105,656 | [
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A new measure of functional evenness and some of its properties. | Functional evenness is increasingly considered an important facet of functional diversity that sheds light on the complex relationships between community assembly and ecosystem functioning. Nonetheless, in spite of its relevant role for ecosystem functioning, only a few measures of functional evenness have been propose... | 25,105,659 | [
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Impact of diabetes on mortality and complications after coronary artery by-pass graft operation in patients with left main coronary artery disease. | Left main disease (LMD) is a severe form of coronary artery disease (CAD). Fifty percent of patients with LMD treated conservatively die within 3-5 years of diagnosis. The aim of the study was to assess the influence of type 2 diabetes on early and late (2-year) prognosis and the risk of complications after coronary ar... | 25,105,661 | [
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[DHS osteosynthesis for proximal femoral fractures: infectious complications]. | Evaluation of infectious complications in patients with proximal femoral fractures treated by osteosynthesis using dynamic hip screws (DHS). The group included 501 patients with 532 DHS procedures performed in the years 1996-2010. In 31 patients osteosynthesis was carried out bilaterally. Osteosynthesis was indicated f... | 25,105,677 | [
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Sexual Dimorphism of Endocranial, Facial and Limb Measurements in the Yellow Baboon (Papio cynocephalus). | The present study focused on the sexual dimorphism of yellow baboon (Papio cynocephalus) to clarify its relationship with social behaviour. The degree of sexual dimorphism in the endocranial volume is the lowest among the investigated measurements. Among the facial measurements, the degree value of sexual dimorphism wa... | 25,105,681 | [
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Power maps and wavefront for progressive addition lenses in eyeglass frames. | To evaluate a method for measuring the cylinder, sphere, and wavefront of progressive addition lenses (PALs) in eyeglass frames. We examine the contour maps of cylinder, sphere, and wavefront of a PAL assembled in an eyeglass frame using an optical system based on a Hartmann test. To reduce the data noise, particularly... | 25,105,689 | [
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The history of neurosurgery at the University of Rochester. | The Department of Neurosurgery at the University of Rochester has a long legacy of excellent patient care and innovation in the neurosciences. The department's founder, Dr. William Van Wagenen, was a direct pupil of Harvey Cushing and the first president of the Harvey Cushing Society. His successor, Dr. Frank P. Smith,... | 25,105,700 | [
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Optimizing dosing of oncology drugs. | The purpose of this article is to acknowledge the challenges in optimizing the dosing of oncology drugs and to propose potential approaches to address these challenges in order to optimize effectiveness, minimize toxicity, and promote adherence in patients. These approaches could provide better opportunities to underst... | 25,105,705 | [
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Keeping consumers safe: food providers' perspectives on pureed food. | Twelve focus groups were conducted in five sites with 80 allied health providers to identify their perspectives on providing pureed food to consumers. Thematic care analysis was completed to summarize and interpret these data. Providers' greatest concern was keeping consumers safe, and the right texture was prioritized... | 25,105,713 | [
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Clinicopathologic features and treatment outcomes of primary extramammary Paget disease of the vulva. | The aim of this study was to identify the clinicopathologic features and treatment outcome of primary extramammary Paget disease of the vulva (EMPDV). We performed a retrospective analysis of 14 patients who were treated at our center from April 1994 to November 2010. The mean age of patients in our sample was 64.4 yea... | 25,105,720 | [
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Metabolic effects of glycerol supplementation and aerobic physical training on Wistar rats. | We evaluated the effects of oral glycerol supplementation on trained rats fed a normal diet. Wistar rats were distributed among 6 groups in a completely randomized 2 × 3 factorial design. The animals were subjected to 6 weeks of aerobic training. In the last 4 weeks, the animals' diet was supplemented with saline, gluc... | 25,105,723 | [
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Identification of bacterial community composition in freshwater aquaculture system farming of Litopenaeus vannamei reveals distinct temperature-driven patterns. | Change in temperature is often a major environmental factor in triggering waterborne disease outbreaks. Previous research has revealed temporal and spatial patterns of bacterial population in several aquatic ecosystems. To date, very little information is available on aquaculture environment. Here, we assessed environm... | 25,105,725 | [
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In vivo immunotoxicity of SiO2@(Y0.5Gd0.45Eu0.05)2O3 as dual-modality nanoprobes. | We have successfully synthesized SiO2@(Y0.5Gd0.45Eu0.05)2O3 nanocomposites as a potential dual-modality nanoprobe for molecular imaging in vitro. However, their immunotoxicity assessment in vivo remains unknown. In this article, the in vitro biocompatibility of our dual-modality nanoprobes was assayed in terms of cell ... | 25,105,724 | [
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Bioactivity and Surface Characteristics of Titanium Implants Following Various Surface Treatments: An In Vitro Study. | This study compared the surface topography, hydrophilicity, and bioactivity of titanium implants after 3 different surface treatments (sandblasting and acid etching, modified sandblasting and acid etching, and thermal oxidation) with those of machined implants. One hundred indigenously manufactured threaded titanium im... | 25,105,748 | [
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Individual and cumulative effects of agriculture, forestry and metal mining activities on the metal and phosphorus content of fluvial fine-grained sediment; Quesnel River Basin, British Columbia, Canada. | The impact of agriculture, forestry and metal mining on the quality of fine-grained sediment (<63 μm) was investigated in the Quesnel River Basin (QRB) (~11,500 km(2)) in British Columbia, Canada. Samples of fine-grained sediment were collected monthly during the snow-free season in 2008 using time-integrated sample... | 25,105,754 | [
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Evolution of oleosin in land plants. | Oleosins form a steric barrier surface on lipid droplets in cytoplasm, preventing them from contacting and coalescing with adjacent droplets. Oleosin genes have been detected in numerous plant species. However, the presence of oleosin genes in the most basally diverging lineage of land plants, liverworts, has not been ... | 25,105,766 | [
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Co-occurrence of papillary thyroid cancer and MALT lymphoma of the thyroid with severe airway obstruction: A case report and review of the literature. | Co-occurrence of papillary thyroid carcinoma (PTC) and mucosa-associated lymphoid tissue (MALT) lymphoma resulting in severe airway obstruction is very rare. A 58-year-old woman visited our department because of enlargement of a neck mass. Computed tomography (CT) and ultrasonography showed 2 discrete hypoechoic nodule... | 25,105,773 | [
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Femoral shaft fractures in adults: treatment options and controversies. | Antegrade reamed femoral nailing via the piriformis entry point is the technique of choice in treating femoral shaft fractures, with retrograde nailing as an alternative. The supine position is favored to reduce complications, especially rotational malalignment. With navigation and robotic assistance fracture reduction... | 25,105,784 | [
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Differential effects of 670 and 830 nm red near infrared irradiation therapy: a comparative study of optic nerve injury, retinal degeneration, traumatic brain and spinal cord injury. | Red/near-infrared irradiation therapy (R/NIR-IT) delivered by laser or light-emitting diode (LED) has improved functional outcomes in a range of CNS injuries. However, translation of R/NIR-IT to the clinic for treatment of neurotrauma has been hampered by lack of comparative information regarding the degree of penetrat... | 25,105,800 | [
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Shaping bacterial symbiosis with legumes by experimental evolution. | Nitrogen-fixing symbionts of legumes have appeared after the emergence of legumes on earth, approximately 70 to 130 million years ago. Since then, symbiotic proficiency has spread to distant genera of α- and β-proteobacteria, via horizontal transfer of essential symbiotic genes and subsequent recipient genome remodelin... | 25,105,803 | [
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Cerebrovascular reactivity to carbon dioxide under anesthesia: a qualitative systematic review. | Controlling the arterial carbon dioxide tension (PaCO2) to reduce the cerebral blood flow (CBF) and the intracranial pressure is a common practice in neuroanesthesia. A change in CBF in response to change in PaCO2 is termed as cerebrovascular reactivity to carbon dioxide (CVR-CO2). Studies have shown that, both inhalat... | 25,105,825 | [
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Exploring Consumer Acceptance of Entomophagy: A Survey and Experiment in Australia and the Netherlands. | Insects are nutritious and suitable for human consumption. In this article an overview of research on consumer acceptance of entomophagy is given. This study furthermore provides insight into which factors are effective to influence consumer acceptance of entomophagy among Dutch and Australian participants. Based on th... | 25,105,864 | [
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Weight loss by telemonitoring of nutrition and physical activity in patients with metabolic syndrome for 1 year. | Mobile technology can improve lifestyle programs, but the monitoring techniques and carer feedback need to be optimized. To this end, we investigated the efficacy of telemonitoring physical activity and nutrition over 12 months in patients with metabolic syndrome in a randomized, parallel-group, open trial. Screening a... | 25,105,874 | [
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Mating damages the cuticle of C. elegans hermaphrodites. | Lifespan costs to reproduction are common across multiple species, and such costs could potentially arise through a number of mechanisms. In the nematode Caenorhabditis elegans, it has been suggested that part of the lifespan cost to hermaphrodites from mating results from physical damage owing to the act of copulation... | 25,105,881 | [
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Human fetal brain-derived neural stem/progenitor cells grafted into the adult epileptic brain restrain seizures in rat models of temporal lobe epilepsy. | Cell transplantation has been suggested as an alternative therapy for temporal lobe epilepsy (TLE) because this can suppress spontaneous recurrent seizures in animal models. To evaluate the therapeutic potential of human neural stem/progenitor cells (huNSPCs) for treating TLE, we transplanted huNSPCs, derived from an a... | 25,105,891 | [
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The impact of pneumolysin on the macrophage response to Streptococcus pneumoniae is strain-dependent. | Streptococcus pneumoniae is the world's leading cause of pneumonia, bacteremia, meningitis and otitis media. A major pneumococcal virulence factor is the cholesterol-dependent cytolysin, which has the defining property of forming pores in cholesterol-containing membranes. In recent times a clinically significant and in... | 25,105,894 | [
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Increased risk of Mycobacterium tuberculosis infection in household child contacts exposed to passive tobacco smoke. | Risk factors associated with Mycobacterium tuberculosis infection were investigated in a prospective cohort of household child tuberculosis contacts. A significantly increased risk of acquiring infection was associated with exposure to passive cigarette smoke, higher number of index cases, younger age and reduced house... | 25,105,895 | [
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Synthesis and characterization of some new 4-hydroxy-coumarin derivatives. | Some novel coumarins were synthesized starting from 4-hydroxycoumarin and methyl bromoacetate. The structures of the newly obtained compounds were confirmed by elemental analysis, mass, IR and NMR spectra. | 25,105,917 | [
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Reliable assessment of physical activity in disease: an update on activity monitors. | Physical activity is the main determinant of variability of individual energy expenditure. Reliable assessment of the activity level of an individual provides information on energy requirement and vital health. Here, evidence is presented on the validity of methods to assess physical activity as applied in health and d... | 25,105,926 | [
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HPV-related squamous neoplasia of the lower anogenital tract: an update and review of recent guidelines. | Squamous cell carcinomas of the lower anogenital tract that are related to human papillomavirus (HPV) infection represent a significant disease burden worldwide. The diagnosis and management of their noninvasive precursors has been the subject of extensive study and debate over several decades, accompanied by an evolvi... | 25,105,936 | [
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Coping with college and inflammatory bowel disease: implications for clinical guidance and support. | Studies have shown that young adults with chronic diseases, including inflammatory bowel disease (IBD), experience greater difficulty during the transition to college, reaching lower levels of educational attainment and reporting greater levels of perceived stress than their otherwise-healthy peers. We performed a qual... | 25,105,948 | [
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A mother cell-to-forespore channel: current understanding and future challenges. | Formation of endospores allows some bacteria to survive extreme nutrient limitation. The resulting dormant cell, the spore, persists in the environment and is highly resistant to physical and chemical stresses. During spore formation, cells divide asymmetrically and the mother cell engulfs the developing spore, encasin... | 25,105,965 | [
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Nitrogen fixed by cyanobacteria is utilized by deposit-feeders. | Benthic communities below the photic zone depend for food on allochthonous organic matter derived from seasonal phytoplankton blooms. In the Baltic Sea, the spring diatom bloom is considered the most important input of organic matter, whereas the contribution of the summer bloom dominated by diazotrophic cyanobacteria ... | 25,105,967 | [
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Environmental perchlorate exposure: potential adverse thyroid effects. | This review will present a general overview of the sources, human studies, and proposed regulatory action regarding environmental perchlorate exposure. Some recent studies have reported significant associations between urinary perchlorate concentrations, thyroid dysfunction, and decreased infant intelligence quotient i... | 25,106,002 | [
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Nitrogen-rich multinuclear ferrocenophanes as multichannel chemosensor molecules for transition and heavy-metal cations. | [m.n] Multinuclear ferrocenophanes prepared by aza-Wittig reaction of bisiminophosphoranes derived from 1,1'-diazidoferrocene and isophthaladelhyde or 2,5-diformylthiophene, behave as efficient electrochemical and chromogenic chemosensor molecules for Zn2+, Pb2+, and Hg2+ metal cations. Whereas the OSWV of receptor 3, ... | 25,106,019 | [
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Analysis of (7)Be behaviour in the air by using a multilayer perceptron neural network. | A multilayer perceptron artificial neural network (ANN) model for the prediction of the (7)Be behaviour in the air as the function of meteorological parameters was developed. The model was optimized and tested using (7)Be activity concentrations obtained by standard gamma-ray spectrometric analysis of air samples colle... | 25,106,024 | [
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Degradation and transformation of atrazine under catalyzed ozonation process with TiO2 as catalyst. | Degradation of atrazine by heterogeneously catalyzed ozonation was carried out with TiO2 in the form of rutile as the catalyst. Some experimental factors such as catalyst dose, ozone dose and initial concentration of atrazine were investigated for their influence on catalyzed ozonation process. Although atrazine was ef... | 25,106,044 | [
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Detection and molecular characterization of porcine circovirus type 2 from piglets with porcine circovirus associated diseases in Colombia. | The porcine circovirus-associated disease (PCVAD) has been known since 1991 in Canada, but the first outbreak of PCVAD in Colombia was reported in 2007. In order to understand the molecular epidemiology of the disease and to establish the origin of the virus in the country, the study presented here intended to evaluate... | 25,106,077 | [
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Long-term stability of return to work after a workplace-oriented intervention for patients on sick leave for burnout. | The period from the mid-1990s to the mid-2000s saw a rapid increase in long-term sick leave in Sweden, primarily due to mental illness and often related to job burnout. This led to an urge for effective treatment programs that could prevent the often long sick leaves. In 2010 we presented a newly developed work-place i... | 25,106,094 | [
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Induction of the matricellular protein CCN1 through RhoA and MRTF-A contributes to ischemic cardioprotection. | Activation of RhoA, a low molecular-weight G-protein, plays an important role in protecting the heart against ischemic stress. Studies using non-cardiac cells demonstrate that the expression and subsequent secretion of the matricellular protein CCN1 is induced by GPCR agonists that activate RhoA. In this study we deter... | 25,106,095 | [
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Quantitative analysis of temperature dependent acoustic trapping characteristics by using concentric annular type dual element ultrasonic transducer. | This paper presents the temperature dependence of lateral acoustic trapping capability by probing the speed of sound in individual lipid droplets at a given temperature of water and measuring its corresponding displacement, a value for quantitatively evaluating a spring-like behavior of the acoustic trap with certain s... | 25,106,111 | [
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Role of astrocytic glycolytic metabolism in Alzheimer's disease pathogenesis. | Alzheimer's disease (AD) has historically been considered to arise due to the specific dysfunction and pathology of neurons in brain areas related to cognition. Recent progress indicates that astrocytes play an important role in neurodegenerative processes underlying AD. In this review, we focus on the different glucos... | 25,106,114 | [
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Chemical characterization of emissions from a municipal solid waste treatment plant. | Gaseous emissions are an important problem in municipal solid waste (MSW) treatment plants. The sources points of emissions considered in the present work are: fresh compost, mature compost, landfill leaks and leachate ponds. Hydrogen sulphide, ammonia and volatile organic compounds (VOCs) were analysed in the emission... | 25,106,121 | [
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Mitochondrial DNA capture and divergence in Pinus provide new insights into the evolution of the genus. | The evolution of the mitochondrial (mt) genome is far from being fully understood. Systematic investigations into the modes of inheritance, rates and patterns of recombination, nucleotide substitution, and structural changes in the mt genome are still lacking in many groups of plants. In this study, we sequenced >11... | 25,106,134 | [
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Assessing item fit for unidimensional item response theory models using residuals from estimated item response functions. | Residual analysis (e.g. Hambleton & Swaminathan, Item response theory: principles and applications, Kluwer Academic, Boston, 1985; Hambleton, Swaminathan, & Rogers, Fundamentals of item response theory, Sage, Newbury Park, 1991) is a popular method to assess fit of item response theory (IRT) models. We suggest ... | 25,106,393 | [
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CB2 Cannabinoid receptors as a therapeutic target-what does the future hold? | The past decades have seen an exponential rise in our understanding of the endocannabinoid system, comprising CB1 and CB2 cannabinoid receptors, endogenous cannabinoids (endocannabinoids), and the enzymes that synthesize and degrade endocannabinoids. The primary focus of this review is the CB2 receptor. CB2 receptors h... | 25,106,425 | [
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0.3056812,
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High matrix metalloproteinase levels are associated with dermal graft failure in diabetic foot ulcers. | The aim of our study is to analyze factors, including matrix metalloproteinase (MMP) levels, that could influence the integration of dermal grafts in diabetic foot ulcers. From September 2012 to September 2013, 35 diabetic patients with IIA lesion (Texas Wound Classification) and an extensive foot tissue loss were cons... | 25,106,443 | [
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0.07882345,
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Isolation and characterization of a Sca-1+/CD31- progenitor cell lineage derived from mouse heart tissue. | Myocardial infarction remains the leading cause of mortality in developed countries despite recent advances in its prevention and treatment. Regenerative therapies based on resident cardiac progenitor cells (CPCs) are a promising alternative to conventional treatments. However, CPCs resident in the heart are quite rare... | 25,106,452 | [
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0.3583353,
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0.1330941,
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In vivo and in vitro evaluation of effects of Mg-6Zn alloy on apoptosis of common bile duct epithelial cell. | Biodegradable magnesium alloy implants have attracted much attention because of their excellent biocompatibility and good mechanical properties. However, effects of Mg alloy on cell apoptosis remain unclear. The aim of this study was to investigate the effects of the Mg-6Zn alloy on the apoptosis and necrosis of common... | 25,106,461 | [
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Pancreatic duct abnormalities in focal autoimmune pancreatitis: MR/MRCP imaging findings. | To evaluate the magnetic resonance (MR) imaging-MR cholangiopancreatographic (MRCP) findings of focal forms of autoimmune pancreatitis (AIP) to describe ductal involvement at diagnosis. MR examinations of 123 patients affected by AIP were analysed. We included 26 patients who satisfied International Consensus Diagnosti... | 25,106,489 | [
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A miniature quantitative PCR device for directly monitoring a sample processing on a microfluidic rapid DNA system. | We report a microfluidic device and measurement method to perform real-time PCR (or qPCR) in a miniaturized configuration for on-chip implementation using reaction volumes of less than 20 μL. The qPCR bioreactor is designed as a module to be embedded in an automated sample-in/profile-out system for rapid DNA biometrics... | 25,106,501 | [
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Progress in stacking techniques based on field amplification of capillary electrophoresis. | Numerous strategies have been developed to mitigate the intrinsic low detection sensitivity that is a limitation of capillary electrophoresis. Among them, in-line stacking is an effective strategy to address the sensitivity challenge, and among the different stacking techniques, stacking based on field amplification is... | 25,106,543 | [
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Applicability of UV laser-induced solid-state fluorescence spectroscopy for characterization of solid dosage forms. | High production output of solid pharmaceutical formulations requires fast methods to ensure their quality. Likewise, fast analytical procedures are required in forensic sciences, for example at customs, to substantiate an initial suspicion. We here present the design and the optimization of an instrumental setup for ra... | 25,106,544 | [
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0.03859615,
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Does change in hostility predict sexual recidivism? | The purpose of the study was to examine whether scores on a widely used measure of hostility--the Buss-Durkee Hostility Inventory (BDHI)--and change on this measure predicted sexual recidivism in a sample of 120 adult male incarcerated sexual offenders. Pre- and posttreatment scores, simple difference scores, and clini... | 25,106,554 | [
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0.3136527,
0.0092... |
A new perturbation theory for electrolyte solutions. | Developing physically based equations of state for electrolyte solutions is demanding due to the long range behaviour of the Coulombic interaction potentials. In this work, we present a new perturbation approach for nonprimitive model electrolyte solutions consisting of hard spheres with a positive or negative point ch... | 25,106,566 | [
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Insertion of liquid crystal molecules into hydrocarbon monolayers. | Atomistic molecular dynamics simulations were carried out to investigate the molecular mechanisms of vertical surface alignment of liquid crystals. We study the insertion of nCB (4-Cyano-4'-n-biphenyl) molecules with n = 0,…,6 into a bent-core liquid crystal monolayer that was recently found to provide good vertical al... | 25,106,607 | [
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0.1694465,
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0.4982449,
-0.2124749,
... |
Many-body effect in ion binding to RNA. | Ion-mediated electrostatic interactions play an important role in RNA folding stability. For a RNA in a solution with higher Mg(2+) ion concentration, more counterions in the solution can bind to the RNA, causing a strong many-body coupling between the bound ions. The many-body effect can change the effective potential... | 25,106,614 | [
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0.001794504,
0.384519,
0.2743593,
-0.08419309,
0.029... |
Nitrogen K-edge X-ray absorption near edge structure (XANES) spectra of purine-containing nucleotides in aqueous solution. | The N K-edge X-ray absorption near edge structure (XANES) spectra of the purine-containing nucleotide, guanosine 5'-monophosphate (GMP), in aqueous solution are measured under various pH conditions. The spectra show characteristic peaks, which originate from resonant excitations of N 1s electrons to π* orbitals inside ... | 25,106,615 | [
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0.02570581,
0.1759092,
0.6404251,
0.08304439,
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Unusual structural properties of water within the hydration shell of hyperactive antifreeze protein. | Many hypotheses can be encountered explaining the mechanism of action of antifreeze proteins. One widespread theory postulates that the similarity of structural properties of solvation water of antifreeze proteins to ice is crucial to the antifreeze activity of these agents. In order to investigate this problem, the st... | 25,106,616 | [
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0.1803772,
0.4591248,
0.3219814,
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... |
The role of melatonin in multiple sclerosis, Huntington's disease and cerebral ischemia. | Melatonin is produced and released by the pineal gland in a circadian rhythm. This neurohormone has proven to be an antioxidant and anti-inflammatory molecule able to reduce or mitigate cell damage associated with oxidative stress and inflammation, and this phenomenon underlies neurodegenerative disorders. These facts ... | 25,106,623 | [
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0.08316499,
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Neuroprotection by association of palmitoylethanolamide with luteolin in experimental Alzheimer's disease models: the control of neuroinflammation. | Alzheimer's disease (AD) is the most common neurodegenerative disorder. Its neuropathological hallmarks include deposition of beta amyloid (Aβ) fibrils in senile plaques. Numerous biochemical events, leading to Aβ neurotoxicity in AD, have been proposed and it seems that neuroinflammation plays a prominent role among t... | 25,106,636 | [
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0.2978679,
0.07861035,
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Potential targets for the development of novel antidepressants: future perspectives. | Depression is an affective disorder characterized by hallucination, delusion and increased social risk and is estimated to affect approximately 20 % of the population at some point during the lifetime. As per World Health Organization (WHO) it is predicted to be the leading cause of burden of disease by 2030. Effects o... | 25,106,638 | [
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0.2705845,
0.1158084,
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0.3659446,
-0.2270034... |
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