title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Novel homozygous mutations in the osteoprotegerin gene TNFRSF11B in two unrelated patients with juvenile Paget's disease. | Most patients with juvenile Paget's disease (JPD) are homozygous for mutations in the gene TNFRSF11B that result in deficiency of osteoprotegerin (OPG) - a key regulator of bone turnover. So far, about 10 different OPG mutations have been described. The current study presents two novel OPG mutations in JPD patients. Pa... | 25,108,083 | [
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Obstructive sleep apnea syndrome: a risk factor for Stanford's type B aortic dissection. | Obstructive sleep apnea syndrome (OSAS) has been associated with aortic dissection (AD), but the magnitude of this association and its independence from confounders have not yet been established. A cross-sectional study was performed in 82 patients with Stanford's Type B AD and 116 controls from May 2009 to October 201... | 25,108,088 | [
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Measurement tools for adherence to non-pharmacologic self-management treatment for chronic musculoskeletal conditions: a systematic review. | To identify measures of adherence to nonpharmacologic self-management treatments for chronic musculoskeletal (MSK) populations; and to report on the measurement properties of identified measures. Five databases were searched for all study types that included a chronic MSK population, unsupervised intervention, and meas... | 25,108,098 | [
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The gene silencing transcription factor REST represses miR-132 expression in hippocampal neurons destined to die. | The gene silencing transcription factor REST [repressor element 1 silencing transcription factor]/NRSF (neuron-restrictive silencer factor) actively represses a large array of coding and noncoding neuron-specific genes important to synaptic plasticity including miR-132. miR-132 is a neuron-specific microRNA and plays a... | 25,108,103 | [
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Hepatocellular toxicity of benzbromarone: effects on mitochondrial function and structure. | Benzbromarone is an uricosuric structurally related to amiodarone and a known mitochondrial toxicant. The aim of the current study was to improve our understanding in the molecular mechanisms of benzbromarone-associated hepatic mitochondrial toxicity. In HepG2 cells and primary human hepatocytes, ATP levels started to ... | 25,108,121 | [
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Associations of parent-adolescent relationship quality with type 1 diabetes management and depressive symptoms in Latino and Caucasian youth. | To examine associations of parent-adolescent relationship quality (parental acceptance and parent-adolescent conflict) with adolescent type 1 diabetes management (adherence and metabolic control) and depressive symptoms in Latinos and Caucasians. In all, 118 adolescents and their mothers (56 = Latino, 62 = Caucasian) c... | 25,108,119 | [
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Adults hospitalised with acute respiratory illness rarely have detectable bacteria in the absence of COPD or pneumonia; viral infection predominates in a large prospective UK sample. | Many adult patients hospitalised with acute respiratory illness have viruses detected but the overall importance of viral infection compared to bacterial infection is unclear. Patients were recruited from two acute hospital sites in Leicester (UK) over 3 successive winters. Samples were taken for viral and bacterial te... | 25,108,123 | [
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Human trophoblasts confer resistance to viruses implicated in perinatal infection. | Primary human trophoblasts were previously shown to be resistant to viral infection, and able to confer this resistance to nontrophoblast cells. Can trophoblasts protect nontrophoblastic cells from infection by viruses or other intracellular pathogens that are implicated in perinatal infection? Isolated primary term hu... | 25,108,145 | [
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cNMP-AMs mimic and dissect bacterial nucleotidyl cyclase toxin effects. | In addition to the well-known second messengers cAMP and cGMP, mammalian cells contain the cyclic pyrimidine nucleotides cCMP and cUMP. The Pseudomonas aeruginosa toxin ExoY massively increases cGMP and cUMP in cells, whereas the Bordetella pertussis toxin CyaA increases cAMP and, to a lesser extent, cCMP. To mimic and... | 25,108,158 | [
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The spinal inhibition of N-type voltage-gated calcium channels selectively prevents scratching behavior in mice. | The present study investigated the effects of pharmacological spinal inhibition of voltage-gated calcium channels (VGCC) in mouse pruritus. The epidural administration of P/Q-type MVIIC or PhTx3.3, L-type verapamil, T-type NNC 55-0396 or R-type SNX-482 VGCC blockers failed to alter the scratching behavior caused by the... | 25,108,164 | [
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Neurophysiological correlates of error monitoring and inhibitory processing in juvenile violent offenders. | Performance monitoring is crucial for well-adapted behavior. Offenders typically have a pervasive repetition of harmful-impulsive behaviors, despite an awareness of the negative consequences of their actions. However, the link between performance monitoring and aggressive behavior in juvenile offenders has not been clo... | 25,108,171 | [
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Recent advances in employing molecular modelling to determine the specificity of glycan-binding proteins. | Impressive improvements in docking performance can be achieved by applying energy bonuses to poses in which glycan hydroxyl groups occupy positions otherwise preferred by bound waters. In addition, inclusion of glycosidic conformational energies allows unlikely glycan conformations to be appropriately penalized. A meth... | 25,108,191 | [
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The Vaccine Safety Datalink: successes and challenges monitoring vaccine safety. | The Vaccine Safety Datalink (VSD) is a collaborative project between the Centers for Disease Control and Prevention (CDC) and 9 health care organizations. Established in 1990, VSD is a vital resource informing policy makers and the public about the safety of vaccines used in the United States. Large linked databases ar... | 25,108,215 | [
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Toward aldehyde and alkane production by removing aldehyde reductase activity in Escherichia coli. | Advances in synthetic biology and metabolic engineering have enabled the construction of novel biological routes to valuable chemicals using suitable microbial hosts. Aldehydes serve as chemical feedstocks in the synthesis of rubbers, plastics, and other larger molecules. Microbial production of alkanes is dependent on... | 25,108,218 | [
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15d-PGJ₂ decreases PGE₂ synthesis in HBx-positive liver cells by interfering EGR1 binding to mPGES-1 promoter. | Microsomal prostaglandin E synthase 1 (mPGES-1) is the terminal regulator of PGE₂ synthesis. The expression of mPGES-1 is increased by stimulating inflammatory factors in various human cancers. However, whether hepatitis B virus (HBV) infection affects mPGES-1 and its molecular mechanism in liver cells has not been stu... | 25,108,236 | [
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Occurrence, distribution, sources and toxic potential of polycyclic aromatic hydrocarbons (PAHs) in surface soils from the Kumasi Metropolis, Ghana. | As a developing country, the economic and population growth rates in Ghana over the past few years have seen a tremendous increase. The growing rate of industrialization is gradually leading to contamination and deterioration of the environment and pollution is likely to reach disturbing levels. Surface soil samples we... | 25,108,249 | [
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Outdoor pilot-scale production of Nannochloropsis gaditana: influence of culture parameters and lipid production rates in tubular photobioreactors. | This work studied outdoor pilot scale production of Nannochloropsis gaditana in tubular photobioreactors. The growth and biomass composition of the strain were studied under different culture strategies: continuous-mode (varying nutrient supply and dilution rate) and two-stage cultures aiming lipid enhancement. Besides... | 25,108,265 | [
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Purification of xylose in simulated hemicellulosic hydrolysates using a two-step emulsion liquid membrane process. | Purification of xylose in simulated hemicellulosic hydrolysates was attempted using a two-step emulsion liquid membrane (ELM) process. The effects of various experimental variables on extraction of each component in the hydrolysates were investigated in the ELM steps. In the first ELM step, acetic acid could be selecti... | 25,108,268 | [
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Secondary biochemical and morphological consequences in lysosomal storage diseases. | More than 50 hereditary lysosomal storage disorders (LSDs) are currently described. Most of these disorders are due to a deficiency of certain hydrolases/glycosidases and subsequent accumulation of nonhydrolyzable carbohydrate-containing compounds in lysosomes. Such accumulation causing hypertrophy of the lysosomal com... | 25,108,325 | [
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Cation-pi interactions at non-redundant protein--RNA interfaces. | Cation-pi interactions have proved to be important in proteins and protein-ligand complexes. Here, cation-pi interactions are analyzed for 282 non-redundant protein-RNA interfaces. The statistical results show that this kind of interactions exists in 65% of the interfaces. The four RNA bases are ranked as Gua>Ade>... | 25,108,327 | [
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Treatment outcomes of childhood tuberculous meningitis: a systematic review and meta-analysis. | Tuberculous meningitis disproportionately affects young children. We aimed to characterise treatment outcomes for this deadliest and most debilitating form of tuberculosis. We did a systematic review and meta-analysis of childhood tuberculous meningitis studies published up to Oct 12, 2012. We included study reports th... | 25,108,337 | [
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"I can do better": exploring purposeful improvement in daily clinical work. | Clinicians' purposeful improvement of practice is vital to maintaining excellence in patient care. This activity is understood as a core competency of adaptive expertise. As part of a broader program of research exploring adaptive expertise in healthcare, this study explored purposeful improvement in paediatric minimal... | 25,108,367 | [
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Proximity of the axillary nerve during bicortical drilling for biceps tenodesis. | Pathology of the biceps tendon can contribute to significant shoulder pain and dysfunction for which biceps tenodesis may be indicated. A variety of techniques tenodesing the biceps tendon have been described. Recently, tenodesis using a uni- or bicortical button has been advocated. This cadaveric study investigates th... | 25,108,370 | [
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Molecular phylogeny and intricate evolutionary history of the three isofunctional enzymes involved in the oxidation of protoporphyrinogen IX. | Tetrapyrroles such as heme and chlorophyll are essential for biological processes, including oxygenation, respiration, and photosynthesis. In the tetrapyrrole biosynthesis pathway, protoporphyrinogen IX oxidase (Protox) catalyzes the formation of protoporphyrin IX, the last common intermediate for the biosynthesis of h... | 25,108,393 | [
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Detection of disseminated tumor cells in bone marrow and circulating tumor cells in blood of patients with early-stage male breast cancer. | Male breast cancer (MBC) is a rare malignant disease, accounting for <1% of all breast cancers (BCs). Treatment of men with early-stage BC is based on standards established in female BC. Prognostic or predictive markers to guide therapeutic decisions, in particular in early-stage male BC, are missing. Here, we explo... | 25,108,406 | [
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Drug-related problems and the clinical role of pharmacists in inpatient mental health: an insight into practice in Australia. | Drug-related problems (DRPs) cause significant morbidity and mortality in healthcare. Clinical pharmacists have shown to reduce DRPs in the inpatient setting. In mental health the effects of clinical pharmacists on DRPs is relatively unknown. To explore the clinical role of inpatient mental health pharmacists and the f... | 25,108,413 | [
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Polyacrylic acid-coated and non-coated iron oxide nanoparticles induce cytokine activation in human blood cells through TAK1, p38 MAPK and JNK pro-inflammatory pathways. | Iron oxide nanoparticles (ION) can have a wide scope of applications in biomedicine, namely in magnetic resonance imaging, tissue repair, drug delivery, hyperthermia, transfection, tissue soldering, and as antimicrobial agents. The safety of these nanoparticles, however, is not completely established, namely concerning... | 25,108,419 | [
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[Mesenchymal stem cells promote mouse breast tumor progression by inducing the suppressive function of myeloid-derived CD11b⁺ Gr1⁺ cells]. | To investigate the role of mesenchymal stem cells (MSCs) in tumor progression by inducing immuno-suppressive function of myeloid-derived CD11b⁺ Gr1⁺ cells (BM-CD11b⁺ Gr1⁺ cells). After co-cultured with MSCs, the immunophenotypes of BM-CD11b⁺ Gr1⁺ cells were tested by flow cytometry. The influence of MSCs on CD11b⁺ Gr1⁺... | 25,108,426 | [
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[Preparation and characterization of monoclonal antibodies against metallothionein of freshwater crab (Sinopotamon henanense)]. | To prepare a monoclonal antibody (mAb) against metallothionein (MT) of freshwater crab (Sinopotamon henanense) and characterize its immunologic properties. Two recombinant MT of S.henanense, namely SUMO-MT and His-MT, were produced by SUMO fusion system and phoA secretion expression system in E.coli. SUMO-MT was used a... | 25,108,438 | [
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MicroRNAs involved in bone formation. | During skeletal development, mesenchymal progenitor cells undergo a multistage differentiation process in which they proliferate and become bone- and cartilage-forming cells. This process is tightly regulated by multiple levels of regulatory systems. The small non-coding RNAs, microRNAs (miRNAs), post-transcriptionally... | 25,108,446 | [
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Models and implementation for relationship problems with dropout. | Allelic dropout in relationship problems may commonly appear in areas such as disaster victim identification and the identification of missing persons. If dropout is not accounted for, the results may be incorrect interpretation of profiles, loss of valuable information and biased results. In this paper, we explore dif... | 25,108,449 | [
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An in silico model for rapid identification of multiple bacteria in resource limited laboratories. | We have developed an in silico model for simplified detection of five major food borne bacteria using common PCR primer based on conserved region flanking a variable region in the first rRNA operon sequences. The RFLP pattern exhibited on virtual SmaI and MboI digestion were unique to each genus. This design is based o... | 25,108,457 | [
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Multi-marker-LD based genetic algorithm for tag SNP selection. | Despite the advances in genotyping technologies which have led to large reduction in genotyping cost, the Tag SNP Selection problem remains an important problem for computational biologists and geneticists. Selecting the smallest subset of tag SNPs that can predict the other SNPs would considerably minimize the complex... | 25,108,458 | [
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Semen quality of consecutive ejaculates from cancer patients for fertility preservation. | To study variations in semen parameters among cancer patients who visited a sperm banking clinic before undergoing cancer treatment. Retrospective, consecutive study. University-based hospital. Eighty-six patients, diagnosed with various cancers, undergoing multiple semen collections on 5 consecutive days, for fertilit... | 25,108,463 | [
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Lignin extraction--reassessment of the severity factor with respect to hydroxide concentration. | Steam processes have often been associated with a severity factor, correlating the cooking temperature, time and catalyst used in the process. Although equations for treatments with and without acid catalyst have been suggested, there is so far no simple equation allowing a precise estimation of the amount of lignin ex... | 25,108,472 | [
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Occurrence and removal of drugs of abuse in Wastewater Treatment Plants of Valencia (Spain). | The occurrence of 8 drugs of abuse and metabolites in the influent and effluent of the 3 Wastewater Treatment Plants (WWTP) that treat wastewater from Valencia was studied in 2011, 2012 and 2013. Target drugs except 6-monoacetylmorphine (6-ACMOR) were detected in 100% of the influents. The WWTPs eliminate cocaine (COC)... | 25,108,491 | [
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Neovascularization and associated fistula formation in a left atrial myxoma: evaluation with multidetector computed tomography. | Although angiographically detectable neovascularity is being reported with increasing frequency in patients with cardiac myxoma, associated coronary fistula to the cardiac chamber has not been described. We report a 62-year-old woman in whom cardiac computed tomography (CT) enabled the noninvasive diagnosis of a left a... | 25,108,497 | [
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Maternal ratings of child health and child obesity, variations by mother's race/ethnicity and nativity. | We examined whether indicators of child health, focusing on obesity, are associated with maternal ratings of child health (MRCH) and its variation by mother's ethnicity/nativity, focusing on Hispanics. The early childhood longitudinal study, kindergarten cohort kindergarten-eighth grade waves (n = 48,814) and nested ge... | 25,108,502 | [
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An acetate switch regulates stress erythropoiesis. | The hormone erythropoietin (EPO), which is synthesized in the kidney or liver of adult mammals, controls erythrocyte production and is regulated by the stress-responsive transcription factor hypoxia-inducible factor-2 (HIF-2). We previously reported that the lysine acetyltransferase CREB-binding protein (CBP) is requir... | 25,108,527 | [
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The availability and the adherence to pediatric guidelines for the management of syncope in the Emergency Department. | To evaluate the impact of the 2009 Italian pediatric clinical guidelines on the management of syncope. A retrospective study of patients who presented to the Emergency Department (ED) of Bambino Gesù Children's Hospital with syncope during the 2 years before and then for 2 years after the establishment of the Italian p... | 25,108,542 | [
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0.1663467,
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Acetylcholinesterase inhibitors from a marine fungus Talaromyces sp. strain LF458. | Two new oxaphenalenone dimers, talaromycesone A (1) and talaromycesone B (2), and a new isopentenyl xanthenone, talaroxanthenone (3), together with six known diphenyl ether derivatives, e.g., Δ(1',3'),-1'-dehydroxypenicillide (4), 1',2'-dehydropenicillide (5), vermixocin A (6), vermixocin B (7), 3'-methoxy-1'2'-dehydro... | 25,108,548 | [
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0.484747,
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Anatomical and physiological regulation of post-fire carbon and water exchange in canopies of two resprouting Eucalyptus species. | The great majority of Eucalyptus spp. are facultative resprouters, and they dominate the eucalypt forests of Australia. Despite this numeric and geographic dominance, there is a general lack of knowledge of their capacity for carbon capture and water loss during canopy reinstation. After a crown-removing fire, we measu... | 25,108,550 | [
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First in vivo application and evaluation of a novel method for non-invasive estimation of cardiac output. | Surgical or critically ill patients often require continuous assessment of cardiac output (CO) for diagnostic purposes or for guiding therapeutic interventions. A new method of non-invasive CO estimation has been recently developed, which is based on pressure wave analysis. However, its validity has been examined only ... | 25,108,554 | [
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No association between plasma adiponectin levels and central auditory function in adults. | Adiponectin might play a protective role in cardiometabolic and peripheral auditory disorders, but its role on central auditory function was still unclear. The aim of this study was to examine whether there is an association between plasma adiponectin levels and central auditory function in adults. We recruited 297 adu... | 25,108,594 | [
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The clinical and pathological features of 133 colorectal cancer patients with brain metastasis: a multicenter retrospective analysis of the Gastrointestinal Tumors Working Committee of the Turkish Oncology Group (TOG). | Brain metastasis in colorectal cancer is highly rare. In the present study, we aimed to determine the frequency of brain metastasis in colorectal cancer patients and to establish prognostic characteristics of colorectal cancer patients with brain metastasis. In this cross-sectional study, the medical files of colorecta... | 25,108,599 | [
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Usefulness of the Palliative Prognostic Index in patients with lung cancer. | The usefulness of the Palliative Prognostic Index (PPI) has been successfully validated in a variety of clinical settings. However, while lung cancer is the leading cause of death worldwide, patients with lung cancer accounted for only 6.9-25.8 % of the study populations in these previous studies. We conducted a retros... | 25,108,600 | [
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Electric control of the spin Hall effect by intervalley transitions. | Controlling spin-related material properties by electronic means is a key step towards future spintronic technologies. The spin Hall effect (SHE) has become increasingly important for generating, detecting and using spin currents, but its strength--quantified in terms of the SHE angle--is ultimately fixed by the magnit... | 25,108,612 | [
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Stable lithium electrodeposition in liquid and nanoporous solid electrolytes. | Rechargeable lithium, sodium and aluminium metal-based batteries are among the most versatile platforms for high-energy, cost-effective electrochemical energy storage. Non-uniform metal deposition and dendrite formation on the negative electrode during repeated cycles of charge and discharge are major hurdles to commer... | 25,108,613 | [
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Skip pedicle screw fixation combined with Ponte osteotomy for adolescent idiopathic scoliosis. | This study aimed to determine whether Ponte osteotomy combined with skip pedicle screw fixation (SPSF) can improve the correction rate and restore thoracic kyphosis for patients with adolescent idiopathic scoliosis. Surgical time, blood loss, preoperative Cobb angle of the main thoracic curve, flexibility, Cobb angle a... | 25,108,620 | [
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The physician's role and empathy - a qualitative study of third year medical students. | Empathy is important in ensuring the quality of the patient-physician relationship. Several studies have concluded that empathy declines during medical training, especially during the third year. However, there is little empirical research on what may influence a medical student's empathy. In addition, studies of empat... | 25,108,627 | [
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Residual behavior and risk assessment of flubendiamide on tomato at different agro-climatic conditions in India. | Supervised field trials were conducted at four different agro-climatic zones in India to evaluate the dissipation pattern and risk assessment of flubendiamide on tomato. Flubendiamide 480 SC was sprayed on tomato at 48 and 96 g active ingredient (a.i.) ha(-1). Samples of tomato fruits were drawn at 0, 1, 3, 5, 7, 10, 1... | 25,108,662 | [
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Whole-body diffusion-weighted MRI for staging lymphoma at 3.0T: comparative study with MR imaging at 1.5T. | To compare 3T and 1.5T Whole Body Diffusion Weighted MRI (WB-DW-MRI) in patients at initial diagnosis of lymphoma. Twenty-three patients were included. We performed a 3.0T and 1.5T WB-DW-MRI with 18 F-Fluoride Positron Emission Tomography Computed Tomography (PET-CT) as the reference standard. Image quality, lymph node... | 25,108,666 | [
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Characterisation of a novel hypovirus from Sclerotinia sclerotiorum potentially representing a new genus within the Hypoviridae. | A novel mycovirus tentatively assigned the name Sclerotinia sclerotiorum hypovirus 2 (SsHV2/5472) was detected in the phytopathogenic fungus Sclerotinia sclerotiorum. The genome is 14581 nucleotides (nts) long, excluding the poly (A) tail. A papain-like cysteine protease (Pro), an RNA-dependent RNA polymerase (RdRp) an... | 25,108,682 | [
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Hemoglobin level and risk of hospitalization and mortality in children on peritoneal dialysis. | Clinical practice guidelines for management of anemia in children with end-stage kidney disease (ESKD) remain largely opinion-based. In this study, we evaluated the risk of mortality and hospitalization by hemoglobin (Hb) level in a large prevalent population of U.S. children on peritoneal dialysis (PD). Hemoglobin lev... | 25,108,709 | [
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Analysis of the bacterial community composition in acidic well water used for drinking in Guinea-Bissau, West Africa. | Potable water is a resource out of reach for millions worldwide, and the available water may be chemically and microbiologically compromised. This is particularly acute in Africa, where water-networks may be non-existent or restricted to a small fraction of the urban population, as in the case of Guinea-Bissau, West Af... | 25,108,716 | [
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Performance and role of N-acyl-homoserine lactone (AHL)-based quorum sensing (QS) in aerobic granules. | The present study investigated the relationship between N-acyl-homoserine lactone (AHL)-based quorum sensing (QS) and the physico-chemical properties of aerobic granules. Stable mature granules were observed in SBR2 and SBR3 with average diameters of 0.96, and 1.49 mm, respectively. The sludge densities of aerobic gran... | 25,108,717 | [
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Adsorption behavior of sulfamethazine in an activated sludge process treating swine wastewater. | Swine wastewater is an important pollution source of antibiotics entering the aquatic environment. In this work, the adsorption behavior of sulfamethazine (SMN), a commonly-used sulfonamide antibiotic, on activated sludge from a sequencing batch reactor treating swine wastewater was investigated. The results show that ... | 25,108,718 | [
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Acute and chronic toxic effects of Pb²⁺ on polychaete Perinereis aibuhitensis: morphological changes and responses of the antioxidant system. | Perinereis aibuhitensis was used to assess adverse biological effects caused by acute and chronic Pb²⁺ exposure in artificial seawater under controlled laboratory conditions. In 96-hr acute toxicity experiments, the morphological changes showed a positive time/dose-dependent tendency, and the 96-hr LC₅₀ value of Pb²⁺ w... | 25,108,724 | [
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Association between germline single nucleotide polymorphisms in the PI3K-AKT-mTOR pathway, obesity, and breast cancer disease-free survival. | Obesity-related hormones and cytokines alter PI3 K-AKT-mTOR pathway activation in breast tumors contributing to poorer disease-free survival (DFS) and decreased responsiveness to tamoxifen and trastuzumab. We hypothesized that single nucleotide polymorphisms (SNPs) in candidate genes in the PI3 K-AKT-mTOR signaling pat... | 25,108,739 | [
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Simultaneous and enantioselective determination of cis-epoxiconazole and indoxacarb residues in various teas, tea infusion and soil samples by chiral high performance liquid chromatography coupled with tandem quadrupole-time-of-flight mass spectrometry. | A novel and sensitive method for simultaneous enantiomeric analysis of two pesticides-cis-epoxiconazole and indoxacarb-in various teas, black tea infusion, and soil samples has been developed. The samples were initially subjected to acetonitrile extraction followed by cleanup using lab-made florisil/graphitized carbon ... | 25,108,768 | [
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Glial activation and midkine and pleiotrophin transcription in the ventral tegmental area are modulated by morphine administration. | Opiates cause persistent restructuring in the mesolimbic reward system. Although a possible role for midkine and pleiotrophin cytokines in the field of synaptic plasticity has been proposed, it has not been assessed whether morphine administration regulates astrogliosis and midkine and pleiotrophin transcription. We ob... | 25,108,770 | [
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Circadian rhythms in cognitive functioning among patients with schizophrenia: impact on signal detection in clinical trials of potential pro-cognitive therapies. | Cognition is affected by circadian rhythms over the course of a day. Circadian rhythms in cognitive functioning are driven by a variety of both endogenous and exogenous factors. Patients with schizophrenia are known to have disturbed circadian rhythms that can affect their cognitive functioning. We examined the impact ... | 25,108,773 | [
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The prevalence of rickettsial and ehrlichial organisms in Amblyomma americanum ticks collected from Ohio and surrounding areas between 2000 and 2010. | The lone star tick, Amblyomma americanum, feeds upon a variety of hosts and is a known vector of several human pathogens. In Ohio, populations of A. americanum have been expanding their range and increasing in abundance and distribution, thereby elevating the public health concerns regarding bites from this species. We... | 25,108,789 | [
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Water quality variation in the highly disturbed Huai River Basin, China from 1994 to 2005 by multi-statistical analyses. | Water quality deterioration is a prominent issue threatening water security throughout the world. Huai River Basin, as the sixth largest basin in China, is facing the most severe water pollution and high disturbance. Statistical detection of water quality trends and identification of human interferences are significant... | 25,108,800 | [
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Improved robotic stereotactic body radiation therapy plan quality and planning efficacy for organ-confined prostate cancer utilizing overlap-volume histogram-driven planning methodology. | This study is to determine if the overlap-volume histogram (OVH)-driven planning methodology can be adapted to robotic SBRT (CyberKnife Robotic Radiosurgery System) to further minimize the bladder and rectal doses achieved in plans manually-created by clinical planners. A database containing clinically-delivered, robot... | 25,108,808 | [
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Atomically thin p-n junctions with van der Waals heterointerfaces. | Semiconductor p-n junctions are essential building blocks for electronic and optoelectronic devices. In conventional p-n junctions, regions depleted of free charge carriers form on either side of the junction, generating built-in potentials associated with uncompensated dopant atoms. Carrier transport across the juncti... | 25,108,809 | [
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Roles of the active site residues and metal cofactors in noncanonical base-pairing during catalysis by human DNA polymerase iota. | Human DNA polymerase iota (Pol ι) is a Y-family polymerase that can bypass various DNA lesions but possesses very low fidelity of DNA synthesis in vitro. Structural analysis of Pol ι revealed a narrow active site that promotes noncanonical base-pairing during catalysis. To better understand the structure-function relat... | 25,108,837 | [
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Vegetation fires and air pollution in Vietnam. | Forest fires are a significant source of air pollution in Asia. In this study, we integrate satellite remote sensing data and ground-based measurements to infer fire-air pollution relationships in selected regions of Vietnam. We first characterized the active fires and burnt areas at a regional scale from MODIS satelli... | 25,108,840 | [
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Intramammary administration of platelet concentrate as an unconventional therapy in bovine mastitis: first clinical application. | Bovine udder infections induce a variety of changes in gene expression of different growth factors that may suggest their possible role in glandular tissue protection or repair processes. Growth factors and also chemokines and cytokines may act synergistically to increase the infiltration of neutrophils and macrophages... | 25,108,856 | [
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Breakthrough candidaemia caused by phenotypically susceptible Candida spp. in patients with haematological malignancies does not correlate with established interpretive breakpoints. | In a study of 27,864 patients with haematological malignancies, 40 patients with candidaemia were identified, among whom 21 developed candidaemia while receiving systemic antifungal therapy [breakthrough candidaemia (BTC)]. Demographic, clinical, microbiological and molecular features of these episodes were analysed. C... | 25,108,876 | [
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Motorcyclist's lane position as a factor in right-of-way violation collisions: a driving simulator study. | A driver turning left and failing to notice an oncoming motorcyclist until too late is the most common cause of motorcycle collisions. Consequently, much previous research has focused on motorcycle properties, such as size, shape, and color to explain its inconspicuousness. However, collision statistics remain largely ... | 25,108,901 | [
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Viscoelastic properties of common suture material used for rotator cuff repair and arthroscopic procedures. | The purpose of this study was to evaluate the viscoelastic properties of 5 suture materials, commonly used in arthroscopic rotator cuff repairs, when subjected to physiological loads. We evaluated 5 commercially available No. 2 sutures undergoing both creep and cyclic testing in both dry air and phosphate-buffered sali... | 25,108,903 | [
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Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA. | Macroautophagy (hereafter autophagy) is a key pathway in neurodegeneration. Despite protective actions, autophagy may contribute to neuron demise when dysregulated. Here we consider X-linked spinal and bulbar muscular atrophy (SBMA), a repeat disorder caused by polyglutamine-expanded androgen receptor (polyQ-AR). We fo... | 25,108,912 | [
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Why banks say NO to great healthcare practitioners. Five reasons why banks reject loans to quality small-business owners and what you can do about it. | If you have a dream of opening or expanding a practice, then bank lending is probably an option you've considered. However, many practitioners are under the false assumption that banks are currently not lending. Untrue! Between 2008 and 2012, banks have loaned an average of $216 billion to small businesses throughout t... | 25,108,988 | [
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Cronobacter: an emergent pathogen causing meningitis to neonates through their feeds. | The recognition of Cronobacter as a public health concern was raised when powdered infant formula (PIF) was linked to several neonatal meningitis outbreaks. It is an opportunistic pathogen that causes necrotising enterocolitis, infantile septicaemia, and meningitis which carries a high mortality rate among neonates. It... | 25,108,996 | [
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Job descriptions made easy. | The act of writing a job description can be a daunting and difficult task for many managers. This article focuses on the key concepts of What, How, and Measureable Results as they relate to an employee's job duties. When the answers to these three elements are articulated, they define the core responsibilities of any j... | 25,108,992 | [
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Keeping our eyes on the eyes: the case of Arcimboldo. | While contemporaries often viewed his reversible composite heads as scherzi (jokes) and modem art connoisseurs as creative masterpieces, Giuseppe Arcimboldo's ingenious paintings served as inspiring stimuli for the present eye-tracking experiment. One group of participants viewed three chosen paintings in an upright, a... | 25,109,013 | [
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Location probability learning requires focal attention. | Target identification is related to the frequency with which targets appear at a given location, with greater frequency enhancing identification. This phenomenon suggests that location probability learned through repeated experience with the target modulates cognitive processing. However, it remains unclear whether att... | 25,109,022 | [
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Interdisciplinary orthodontics: a case report. | Replacement of the impacted maxillary canines with implants is a great challenge for all dentists. Adequate implant space, sufficient space between the roots, alveolar bone bed, thin labialgingiva and the guiding role of canine in a mutually protected occlusion make the choice of implant position with proper diameter m... | 25,109,057 | [
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Peripheral neuropathy may increase the risk for asymptomatic otic barotrauma during hyperbaric oxygen therapy: research report. | Otic barotrauma (OBT) is an adverse event seen in patients receiving hyperbaric oxygen (HBO2) therapy. After encountering a case of painless tympanic perforation during HBO2 therapy of a diabetic patient with the diagnosis of neuropathic Wagner Grade III foot ulcer, we hypothesized that peripheral neuropathy of the low... | 25,109,078 | [
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Hyperbaric oxygenation therapy for crush injuries reduces the risk of complications: research report. | Hyperbaric oxygen (HBO2) therapy has been adopted for crush injuries, but there are few studies supporting its use. We therefore investigated the effects of HBO2 on management of patients with complicated crush injuries. This historic cohort study included patients with crush injuries and open fractures with severities... | 25,109,081 | [
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Decompression illness in goats following simulated submarine escape: 1993-2006. | The United Kingdom Ministry of Defence commissioned work to define the relationship between the internal pressure of a distressed submarine (DISSUB), the depth from which escape is made and the risk of decompression illness (DCI). The program of work used an animal model (goat) to define these risks and this paper repo... | 25,109,083 | [
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0.06631264,
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0.06182506,
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-0.41503,
0.002784667,
0.02373281,
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0.04977718,
0.2432881,
-0.08030315... |
Edmund Pellegrino's philosophy and ethics of medicine: an overview. | It might seem ironic that the author in this mini-symposium who knew Edmund Pellegrino the best should be the one whose essay is the least personal,eschewing anecdote and reminiscence and concentrating on the substance of his scholarly contribution. I think, however, that for Ed, an exposition of his ideas would be the... | 25,109,090 | [
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... |
The A-test--reliability of functional recovery assessment during early rehabilitation of patients in an orthopedic ward. | There are few tests for evaluation of functional abilities of patients surgically treated for hip fractures or osteoarthritis during early rehabilition period. The aim of this study was to investigate reliability (interobserver reproducibility and internal consistency) of the A-test, an original test for functional rec... | 25,109,110 | [
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Performance management tools motivate change at the frontlines. | Performance management tools commonly used in business, such as incentives and the balanced scorecard, can be effectively applied in the public healthcare sector to improve quality of care. The province of Alberta applied these tools with the Institute for Health Improvement Learning Collaborative method to accelerate ... | 25,109,132 | [
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0.283... |
Ultrasound-guided interscalene-supraclavicular block for an intramedullary nailing of a pathologic humeral fracture: practical application of ultrasound-guided regional anesthesia. | Fractures of the proximal upper extremity present a challenge to the anesthesia provider when administering a regional anesthetic because the dermatomal distribution of the upper extremity requires more local anesthetic coverage than any single brachial plexus nerve block can provide. A 60-year-old woman underwent intr... | 25,109,160 | [
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Reexamining traditional intraoperative fluid administration: evolving views in the age of goal-directed therapy. | Intraoperative volume administration has long been a topic of debate in the field of anesthesia. Only recently, however, has the conversation shifted to a discussion of appropriate intraoperative volume. A thorough review of the literature explores the history of today's widely accepted fluid administration equation an... | 25,109,164 | [
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A critical review of nuisance foam formation and biological methods for foam management or elimination in nutrient removal facilities. | The classifying selector was introduced to the wastewater industry in 2001, after several successful full-scale applications. The classifying selector concept distinguishes itself from the earlier surface foam wasting schemes in that negative selection pressure is maintained so that nuisance foam-causing organisms cann... | 25,109,195 | [
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0.1275923,
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0.1756321,
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Efficient removal of arsenic (V) from water using steel-making slag. | This study describes the potential use of steel-making slag as an arsenic-removal medium. Systematic analysis of slag material revealed a composition of oxides of calcium, iron, silicon, and phosphorous. Under the experimental conditions of this study, the equilibrium time was shown to be 2 hours, and the removal capac... | 25,109,198 | [
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0.05169872,
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0.266985,
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Incorporating a compact proton therapy unit into an existing National Cancer Institute-designated comprehensive cancer center. | Proton beams offer specific dosimetric advantages for radiation therapy. Their depth-dose relationship is characterized by the Bragg peak beyond which no dose is deposited. The elimination of exit dose for passively scattered proton beams results in greatly reduced low and intermediate doses to distant uninvolved norma... | 25,109,233 | [
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0.... |
In situ metabolic analysis of single plant cells by capillary microsampling and electrospray ionization mass spectrometry with ion mobility separation. | Advances in single cell analysis techniques have demonstrated cell-to-cell variability in both homogeneous and heterogeneous cell populations strengthening our understanding of multicellular organisms and individual cell behaviour. However, additional tools are needed for non-targeted metabolic analysis of live single ... | 25,109,271 | [
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0.1189452,
0.2787719,
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... |
Lorcaserin, a selective 5-HT(2C) receptor agonist, decreases alcohol intake in female alcohol preferring rats. | Serotonergic systems in the brain have been found to be important in the addiction to alcohol. The purpose of this study was to evaluate the efficacy of a novel 5-HT2c receptor agonist, lorcaserin for reducing alcohol consumption in alcohol-preferring (P) rats. Adult female rats were allowed to drink water or alcohol (... | 25,109,272 | [
0.04053163,
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... |
Alternative method of allelic discrimination. | 5' nuclease assays for allelic discrimination use both a wild-type and a mutant probe. Here we present a new method for genotyping by 5' nuclease assays that dispenses with the mutant probe, using the wild-type probe together with a probe for a reference gene known to be present in two copies to determine the copy numb... | 25,109,294 | [
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0.0... |
Clostridium difficile: improving the prevention paradigm in healthcare settings. | Clostridium difficile infection (CDI) is a major public health problem worldwide with significant morbidity and mortality that is spread by spores and fecal oral transmission. A variety of risk factors have been identified. Some risk factors such as age, are not amenable to change, while others such as antimicrobial ut... | 25,109,301 | [
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... |
Controlling resistant bacteria with a novel class of β-lactamase inhibitor peptides: from rational design to in vivo analyses. | Peptide rational design was used here to guide the creation of two novel short β-lactamase inhibitors, here named dBLIP-1 and -2, with length of five amino acid residues. Molecular modeling associated with peptide synthesis improved bactericidal efficacy in addition to amoxicillin, ampicillin and cefotaxime. Docked str... | 25,109,311 | [
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0.3537999,
0.1665565,
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0.0743429... |
Single-centre cross-sectional analysis of advance care planning among elderly inpatients. | Advance care planning (ACP) has been shown to provide beneficial outcomes for elderly patients; however, it may not be commonly implemented. To assess prevalence of advance care directives (ACD) and documented medical orders about end-of-life care for elderly inpatients; to explore the feasibility of an ACP screening i... | 25,109,312 | [
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Assessment of left atrial volume before and after pulmonary thromboendarterectomy in chronic thromboembolic pulmonary hypertension. | Impaired left ventricular diastolic filling is common in chronic thromboembolic pulmonary hypertension (CTEPH), and recent studies support left ventricular underfilling as a cause. To investigate this further, we assessed left atrial volume index (LAVI) in patients with CTEPH before and after pulmonary thromboendartere... | 25,109,313 | [
0.0271631,
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Spanish consensus document for acceptance and rejection of kidneys from expanded criteria donors. | In the recent years, more than 60% of available deceased donors are either older than 50 yr or have significant vascular comorbidities. This makes the acceptance and rejection criteria of renal allografts very rigorous, especially in cases of younger recipients, and at the same time encourages live donations. In our co... | 25,109,314 | [
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Tension on the linker gates the ATP-dependent release of dynein from microtubules. | Cytoplasmic dynein is a dimeric motor that transports intracellular cargoes towards the minus end of microtubules (MTs). In contrast to other processive motors, stepping of the dynein motor domains (heads) is not precisely coordinated. Therefore, the mechanism of dynein processivity remains unclear. Here, by engineerin... | 25,109,325 | [
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Continuous hypoxia regulates the osteogenic potential of mesenchymal stem cells in a time-dependent manner. | The effects of hypoxia on the osteogenic potential of mesenchymal stem cells (MSCs) have been previously reported. From these studies, possible factors affecting the association between hypoxia and the osteogenic differentiation of MSCs have been suggested, including hypoxia severity, cell origin and methods of inducti... | 25,109,357 | [
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0.06783128,
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0... |
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