title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
|---|---|---|---|
LiftingWiSe: a lifting-based efficient data processing technique in wireless sensor networks. | Monitoring thousands of objects which are deployed over large-hard-to-reach areas, is an important application of the wireless sensor networks (WSNs). Such an application requires disseminating a large amount of data within the WSN. This data includes, but is not limited to, the object's location and the environment co... | 25,116,902 | [
0.06963478,
-0.0196835,
-0.0427976,
-0.206203,
0.05708626,
-0.3707773,
-0.2189824,
-0.02112515,
0.07217681,
-0.1601385,
-0.2252028,
-0.05833972,
0.100289,
0.06802836,
-0.5937493,
0.01598203,
-0.4570297,
0.09258764,
-0.2304842,
-0.215192,
0.06306642,
0.1415023,
-0.275254,
... |
Expression of vesicular glutamate transporter 3 mRNA in the brain and retina of the pigeon. | Vesicular glutamate transporters (vGluTs), which accumulate glutamate into synaptic vesicles, are classified into three subtypes in mammalian brains: vGluT1, vGluT2, and vGluT3. VGluT3 is localized in non-glutamatergic neurons of the brain and retinal amacrine cells. In birds, the vGluT3 genome is found, but its distri... | 25,116,931 | [
-0.211054,
0.08512816,
-0.4230306,
-0.3894123,
0.006496274,
-0.3385033,
-0.1897141,
0.05512369,
0.003498558,
-0.01349226,
0.2776545,
0.3186873,
-0.00887585,
0.208193,
-0.2912649,
0.09195732,
-0.5150226,
0.298018,
0.2317268,
-0.2964283,
0.3492284,
0.4098049,
0.1125187,
-... |
Value of water mazes for assessing spatial and egocentric learning and memory in rodent basic research and regulatory studies. | Maneuvering safely through the environment is central to survival of all animals. The ability to do this depends on learning and remembering locations. This capacity is encoded in the brain by two systems: one using cues outside the organism (distal cues), allocentric navigation, and one using self-movement, internal c... | 25,116,937 | [
-0.345295,
0.1783913,
0.1232347,
-0.3313457,
0.07468984,
-0.5842018,
-0.2490649,
-0.5441242,
0.1188992,
-0.129515,
-0.1354366,
0.4463669,
0.2391744,
-0.2558172,
-0.3904725,
-0.03697836,
-0.3084104,
0.4180914,
-0.5159682,
-0.1103188,
-0.3065476,
0.0951888,
0.0201588,
-0.... |
Main trunk crossover stenting in a patient with left internal thoracic artery--protected single coronary artery. | A 74-year-old man with single coronary artery and history of previous coronary artery bypass graft (CABG) was admitted to our hospital with worsening angina. Because of high risk of redo-CABG, we performed transradial percutaneous coronary intervention against the just proximal left anterior descending coronary artery ... | 25,117,026 | [
-0.01331714,
0.3051405,
-0.1489986,
-0.01653626,
0.09093018,
-0.1859245,
0.08481862,
-0.3444368,
0.03756635,
-0.1022974,
0.08893669,
0.1363253,
-0.3033544,
-0.0372103,
0.08897726,
-0.07098901,
-0.5274133,
0.3243545,
-0.06389374,
-0.3653368,
-0.03964484,
0.2452566,
0.07416... |
Toxicity of naturally occurring Bio-fly and chitosan compounds to control the Mediterranean fruit fly Ceratitis capitata (Wiedemann). | The efficacy of five compounds of a biopolymer chitosan and Bio-fly (Beauveria bassiana fungus) as biopesticide was evaluated on Ceratitis capitata under laboratory conditions. The inhibitory effects on acetylcholinesterase (AChE) and adenosinetriphosphatase (ATPase) as biochemical indicators were also determined in vi... | 25,117,027 | [
-0.08466818,
0.182529,
-0.01238278,
0.1047818,
0.05973406,
0.1221201,
0.09888325,
0.1408215,
-0.07399467,
-0.3703321,
0.06340159,
-0.1137607,
0.3595465,
-0.1595391,
-0.7009425,
0.1714694,
-0.6218518,
0.476841,
0.1398792,
0.1521052,
0.228113,
0.4730346,
-0.09066375,
0.13... |
[Factors associated with health promoting behaviors among Chilean adolescents]. | Health-promoting behaviors are important to prevent diseases and prolong life in the population. People develop these behaviors throughout life. However, better benefits for health are obtained with an early development. To determine the prevalence of health-promoting behaviors among early adolescents and its associate... | 25,117,031 | [
-0.1091664,
0.06940173,
0.2102141,
0.1645771,
0.03478689,
-0.08789819,
-0.1359167,
-0.001485444,
-0.07825534,
-0.3803165,
-0.1415011,
-0.3788134,
-0.3904455,
-0.6266909,
-0.5002992,
-0.3514301,
-0.1878654,
0.3003562,
0.0960098,
0.1225239,
0.1765399,
0.05910713,
-0.3132088... |
[A proposal for the definitive reform of the private health insurance system in Chile]. | Private health insurance should be able to provide coverage to people considered as high risk, such as women and the elderly. The only way to do that is to organize implicit or explicit cross-subsidies from low to high-risk individuals. This paper examines how European private health insurance companies introduced regu... | 25,117,041 | [
-0.1709171,
-0.02212957,
0.5970637,
0.367231,
0.3617763,
-0.2210907,
-0.08076508,
0.0530927,
-0.09607001,
-0.05379149,
-0.08482495,
-0.1116654,
-0.274644,
-0.2143009,
-0.5266649,
-0.6165031,
-0.283213,
0.03919293,
-0.2093592,
-0.3060884,
0.1144004,
0.2275669,
-0.01581911,... |
Real-time analysis of endogenous protoporphyrin IX fluorescence from δ-aminolevulinic acid and its derivatives reveals distinct time- and dose-dependent characteristics in vitro. | Photodynamic therapy (PDT) and photodiagnosis based on the intracellular production of the photosensitizer protoporphyrin IX (PPIX) by administration of its metabolic precursor -aminolevulinic acid (ALA) achieved their breakthrough upon the clinical approval of MAL (ALA methyl ester) and HAL (ALA hexyl ester). For newl... | 25,117,078 | [
-0.2423375,
-0.4599451,
-0.4714967,
0.2662099,
0.2674423,
0.09904439,
-0.1910543,
0.5547169,
0.433623,
-0.03333974,
-0.0175926,
-0.09484837,
0.1154619,
-0.3590769,
-0.2629485,
0.2631942,
-0.422886,
0.2454563,
-0.2128772,
0.4205357,
0.513986,
0.3860862,
-0.2547194,
0.301... |
Identification of cancer stem cells and a strategy for their elimination. | It has been established previously that up to 40% of mouse CD34(+) hematopoietic stem cells are capable of internalizing exogenous dsDNA fragments both in vivo and ex vivo. Importantly, when mice are treated with a combination of cyclophosphamide and dsDNA, the repair of interstrand crosslinks in hematopoietic progenit... | 25,117,082 | [
0.08489824,
-0.005683507,
-0.1559713,
-0.2455141,
0.3808188,
-0.03006021,
-0.0388444,
0.2411724,
0.2120785,
0.09340216,
-0.08932417,
0.02962209,
0.1290571,
0.03074423,
-0.6971298,
0.08991464,
-0.3652709,
-0.1436465,
-0.01119768,
0.1811673,
0.1565644,
-0.1514452,
-0.179694... |
Correlation between low folate levels and hyperhomocysteinemia, but not with vitamin B12 in hypertensive patients. | Hypertension is considered to be among the most important risk factors for cardiovascular and cerebrovascular diseases. In recent years, several investigators have reported that high plasma levels of total homocysteine (t-hcy) has a key role in the development of hypertension, and the deficiency of B complex vitamins c... | 25,117,099 | [
-0.2576883,
-0.002890083,
-0.1501594,
-0.1656976,
0.247585,
-0.2062529,
0.03307743,
0.08694465,
-0.315058,
-0.04947701,
0.2000208,
0.6468025,
-0.0825317,
0.112515,
-0.3061848,
-0.1572258,
-0.1427534,
0.2852639,
-0.08593969,
0.1607846,
-0.07803571,
0.6448337,
-0.1456511,
... |
Novel ABCC8 (SUR1) gene mutations in Asian Indian children with congenital hyperinsulinemic hypoglycemia. | Congenital hyperinsulinemic hypoglycemia (HI) is a heterogeneous genetic disorder of insulin secretion characterized by persistent hypoglycemia, most commonly associated with inactivating mutations of the β-cell ATP-sensitive K(+) channel (K(ATP) channel) genes ABCC8 (encoding SUR1) and KCNJ11(encoding Kir6.2). This st... | 25,117,148 | [
-0.005592815,
-0.08337799,
-0.2006062,
-0.1756197,
0.18985,
0.178886,
-0.08230893,
0.1577811,
0.3037616,
0.03151862,
0.5145384,
0.3645244,
-0.3581043,
0.01274245,
-0.1152221,
-0.4089017,
-0.3672532,
0.2795744,
0.001233086,
-0.3076517,
-0.3478911,
0.2334127,
0.1931408,
-... |
Dermatological toxicity associated with targeted therapies in cancer: optimal management. | Targeted therapies have developed rapidly over the last few years in the field of oncology thanks to a better understanding of carcinogenesis. They target pathways involved in signal transduction (EGFR, HER2, HER3, HER4, FLT3, RAS, RAF, MEK, KIT, RET, mTOR, SRC, EPH, SCF), tumor angiogenesis (VEGFR, TIE2), and tumor mi... | 25,117,153 | [
0.07356498,
-0.07181842,
0.2602552,
-0.2259117,
-0.06530698,
-0.2459559,
0.1596261,
0.1182395,
-0.04972069,
0.155971,
0.1447154,
-0.2193634,
-0.1233972,
-0.134697,
-0.3085076,
-0.1971366,
-0.07228934,
-0.01723423,
0.1871047,
0.08876447,
-0.04364355,
0.4164346,
-0.2309806,... |
Neuropsychological Assessment of Children With Reading Disabilities From 8 to 10 Years Old: An Exploratory Portuguese Study. | Reading disabilities are one of the most significant causes of school failure and may result from different causes and cognitive processes. A comprehensive battery of neuropsychological tests was applied to a control group of 102 children (46 girls, 56 boys) with no history of learning disabilities and 32 children (13 ... | 25,117,206 | [
-0.09126826,
0.3196042,
0.3505898,
-0.02356268,
0.3223673,
-0.4990736,
-0.02869808,
-0.1807096,
-0.04695277,
-0.03892986,
0.2420037,
0.3595875,
-0.2995541,
-0.3936796,
-0.3730682,
-0.04885812,
-0.1516446,
0.1456972,
-0.1329286,
-0.04643533,
0.1896844,
0.2103193,
-0.080426... |
NMR analysis of carbohydrate-binding interactions in solution: an approach using analysis of saturation transfer difference NMR spectroscopy. | One of the most commonly used ligand-based NMR methods for detecting ligand binding is saturation transfer difference (STD) nuclear magnetic resonance (NMR) spectroscopy. The STD NMR method is an invaluable technique for assessing carbohydrate-lectin interactions in solution, because STD NMR can be used to detect weak ... | 25,117,260 | [
-0.1632523,
-0.1512277,
0.1336818,
-0.08555236,
-0.1101326,
-0.08303875,
-0.0711152,
0.07181504,
0.07543143,
0.2569082,
-0.2734517,
0.1514328,
0.1287809,
-0.1239665,
-0.5478547,
-0.01420073,
-0.8984156,
0.1176223,
-0.03779762,
-0.1556934,
0.1726754,
0.192849,
-0.08553839,... |
Structural basis for constitutive activity and agonist-induced activation of the enteroendocrine fat sensor GPR119. | GPR119 is a Gαs-coupled 7TM receptor activated by endogenous lipids such as oleoylethanolamide (OEA) and by the dietary triglyceride metabolite 2-monoacylglycerol. GPR119 stimulates enteroendocrine hormone and insulin secretion. But despite massive drug discovery efforts in the field, very little is known about the bas... | 25,117,266 | [
0.07530542,
-0.1224267,
-0.2083988,
-0.277963,
0.2445634,
-0.02796752,
-0.0273801,
0.2450617,
0.2277861,
0.2042309,
0.1224353,
-0.2099757,
-0.2147108,
-0.06393091,
-0.3946733,
0.3074598,
-0.5000505,
0.005006847,
-0.2721703,
0.185435,
0.2848956,
0.5782322,
-0.1338082,
-0... |
Chemical genomics screening for biomodulators of endomembrane system trafficking. | Cell proteins traffic through complex and tightly regulated pathways. Although the endomembrane system is essential, its different pathways are still not well understood. In order to dissect protein trafficking pathways, chemical genomic screenings have been performed. This strategy has been utilized to successfully di... | 25,117,289 | [
0.1179774,
-0.09539398,
0.03123298,
-0.1263692,
-0.02106205,
-0.134741,
0.01996652,
0.01791797,
0.150741,
-0.1570257,
0.1055036,
-0.004455555,
0.03146521,
-0.07051443,
-0.5727671,
0.3224255,
-0.6093553,
0.1868193,
0.1144407,
-0.06797922,
0.1830084,
0.5042934,
-0.2187277,
... |
Increased serum levels of GDF-15 associated with mortality and subclinical atherosclerosis in patients on maintenance hemodialysis. | Increased carotid intima-media thickness (CIMT) was shown to be an independent predictor of cardiovascular (CV) mortality in dialysis patients and the general population. Growth differentiation factor 15 (GDF-15), a member of the transforming growth factor superfamily, is produced by cardiomyocytes and atherosclerotic ... | 25,117,302 | [
-0.1565868,
-0.3693923,
0.04413464,
-0.1628083,
0.203515,
-0.1388819,
-0.1829823,
0.1193607,
0.02919771,
-0.1784209,
-0.03433738,
0.07050399,
-0.4174815,
0.1111337,
0.1116692,
-0.2350014,
-0.5094491,
0.09281671,
-0.2509054,
0.4368732,
-0.4026881,
0.1686819,
-0.368378,
-... |
Development of polymorphic expressed sequence tag-single sequence repeat markers in the common Chinese cuttlefish, Sepiella maindroni. | The common Chinese cuttlefish (Sepiella maindroni) is one of the popular edible cephalopod consumed across Asia. To facilitate the population genetic investigation of this species, we developed fourteen polymorphic microsatellite makers from expressed sequence tags of S. maindroni. The number of alleles at each locus r... | 25,117,305 | [
0.02392165,
0.08269803,
0.1498705,
-0.1356492,
0.06475395,
-0.04927932,
-0.1674374,
0.1710639,
0.1347842,
-0.01908373,
0.1830768,
0.1460684,
-0.08862002,
0.3468609,
-0.2356696,
-0.3709951,
-0.4050487,
0.1205749,
0.3514026,
0.1831997,
0.04236792,
0.2442986,
-0.004915049,
... |
Multiple nevoid basal cell carcinoma syndrome associated with congenital orbital teratoma, caused by a PTCH1 frameshift mutation. | Gorlin-Goltz syndrome, or nevoid basal cell carcinoma syndrome (NBCCS), is a rare autosomal dominant disorder caused by mutations in the PTCH1 gene and shows a high level of penetrance and variable expressivity. The syndrome is characterized by developmental abnormalities or neoplasms and is diagnosed with 2 major crit... | 25,117,323 | [
0.03606848,
-0.1680747,
-0.1525293,
-0.4235543,
0.06166537,
-0.3022005,
-0.1162738,
-0.007335011,
0.1748344,
0.4000843,
0.1508607,
0.09130863,
-0.282035,
-0.2666124,
-0.08866803,
-0.1687469,
-0.4132836,
-0.2095791,
0.1926733,
-0.1025117,
0.3358437,
0.5724826,
0.001592897,... |
Effect of Jianpi Bushen prescription on the expression of SHP-1 and apoptosis-related genes in chemically damaged model mice. | We investigated the effect of Jianpi Bushen prescription (JBP) on the expression of the SHP-1 and apoptosis-related genes in chemically damaged model mice and a compound e-jiao slurry (EJS) group (positive control). Kunming mice received an abdominal injection of 100 mg/kg cyclophosphamide once a day for 3 consecutive ... | 25,117,354 | [
-0.1947402,
0.4889199,
0.04013126,
0.08346079,
0.2315478,
-0.2064341,
-0.4053565,
0.06820302,
0.126763,
0.04798218,
0.2831894,
0.3023247,
-0.1061899,
0.3963086,
-0.6329276,
-0.1668417,
-0.111421,
-0.08422315,
0.06768359,
0.308057,
0.2712924,
0.1751207,
-0.01683099,
-0.2... |
Effects of simulated weightlessness on cellular morphology and biological characteristics of cell lines SGC-7901 and HFE-145. | We investigated the effects of simulated weightlessness on cellular morphology, proliferation, cell cycle, and apoptosis of the human gastric carcinoma cell line SGC-7901 and the human gastric normal cell line HFE-145. A rotating clinostat was used to simulate weightlessness. The Image-Pro4.5 image analysis system was ... | 25,117,363 | [
-0.1907732,
0.06914582,
-0.1113576,
-0.1120151,
0.2635666,
-0.05782178,
0.118199,
-0.249528,
0.4636427,
0.2699325,
-0.1689441,
0.04351219,
-0.5282512,
-0.2084561,
-0.07232399,
0.1730331,
-0.2059206,
0.3921608,
-0.3259115,
0.330982,
0.2553757,
0.3549211,
-0.173421,
0.160... |
Influence of neural stem cell transplantation on angiogenesis in rats with spinal cord injury. | We examined the influence of neural stem cell transplantation on angiogenesis in rats with spinal cord injury. Sixty rats with spinal cord injury were divided into an experimental group and a control group and given neural stem cells or an equivalent amount of phosphate-buffered saline by intravenous transplantation, r... | 25,117,366 | [
0.1102729,
0.06162745,
-0.2327801,
-0.1403391,
0.2515448,
-0.3391518,
-0.001302324,
0.1364749,
-0.346453,
0.01447283,
0.0549253,
0.02790088,
-0.4851049,
-0.3755342,
-0.09213082,
-0.208906,
-0.1023072,
0.212946,
-0.1821302,
0.07414911,
-0.02792584,
0.3014572,
0.2668589,
... |
Variants -250G/A and -514C/T in the LIPC gene are associated with hypertensive disorders of pregnancy in Chinese women. | We examined the influence of the promoter polymorphisms -250G/A (rs2070895) and -514C/T (rs1800588) in the human hepatic lipase (LIPC) gene on dyslipidemia and hypertensive disorders complicating pregnancy (HDCP) in a Chinese population. Clinically defined HDCP patients (N = 321) and healthy pregnant women (N = 331) we... | 25,117,371 | [
0.1909568,
-0.242534,
0.05563207,
-0.2103305,
-0.01340447,
-0.03699517,
-0.05525368,
-0.2890838,
0.2140706,
0.1866219,
0.07817506,
0.06207204,
0.0360346,
0.3592018,
-0.3834075,
-0.436945,
-0.381242,
-0.09383541,
0.122805,
0.2065754,
-0.3481394,
0.4869303,
-0.0620062,
0.... |
Incontinentia Pigmenti in 22-month Old Afro-Caribbean Fraternal Twin Girls. A Case Report. | Incontinentia pigmenti is a rare X-linked dominant condition characterized by cutaneous, neural, ocular and dental manifestations. The condition has mainly been reported in Caucasian females. The aim of this case report is to highlight the clinical presentation in Afro-Caribbean twin girls. The girls demonstrated abnor... | 25,117,394 | [
-0.0177465,
-0.2968744,
0.09162535,
-0.1270499,
-0.01101889,
-0.561563,
-0.388207,
-0.01080076,
0.006721454,
-0.02137935,
0.2568533,
0.7093085,
-0.3168161,
0.00971166,
-0.1134193,
-0.5687585,
-0.3554357,
-0.1698564,
-0.1846838,
-0.6306266,
0.1597932,
0.3539568,
-0.1201279... |
Double bag or Y-set versus standard transfer systems for continuous ambulatory peritoneal dialysis in end-stage kidney disease. | Peritonitis is the most frequent serious complication of continuous ambulatory peritoneal dialysis (CAPD). It has a major influence on the number of patients switching from CAPD to haemodialysis and has probably restricted the wider acceptance and uptake of CAPD as an alternative mode of dialysis.This is an update of a... | 25,117,423 | [
-0.08481124,
0.06337339,
0.1747492,
0.121688,
-0.05960034,
-0.4158341,
0.02924887,
-0.3073057,
-0.09170064,
-0.217658,
-0.1250965,
-0.340613,
-0.1417476,
0.3797575,
-0.3326036,
-0.4233311,
-0.1327416,
-0.00063039,
-0.1300084,
-0.09015645,
-0.261437,
0.2568288,
-0.2296231,... |
Draft genome sequence of Rhodomicrobium udaipurense JA643T with special reference to hopanoid biosynthesis. | Hopanoids are present in vast amounts as integral components of bacteria and plants with their primary function to strengthen rigidity of the plasma membrane. To establish their roles more precisely, we conducted sequencing of the whole genome of Rhodomicrobium udaipurense JA643(T) isolated from a fresh water stream of... | 25,117,430 | [
0.0747172,
-0.2596928,
0.07325528,
-0.5307561,
0.4221334,
-0.2629815,
-0.2023496,
-0.1914431,
0.1684178,
-0.1625895,
0.0735489,
0.0927006,
-0.153584,
-0.1645102,
-0.7731109,
-0.01232849,
-0.5886199,
0.5993412,
-0.1755854,
0.0218668,
0.3023124,
0.311414,
-0.4072852,
-0.1... |
Inhibition of N-acetylglucosaminyltransferase V enhances sensitivity of radiotherapy in human prostate cancer. | The purpose of this study was to investigate the relationship between N-acetylglucosaminyltransferase V (GnT-V) and radiation sensitivity of prostate cancer (PCa) cells both in vitro and in vivo. Firstly, the GnT-V expression was studied in 84 cases of PCa tissues, in which higher level of GnT-V was detected more frequ... | 25,117,443 | [
0.003340509,
-0.3447307,
-0.3967768,
-0.1682281,
-0.002925232,
0.06588344,
0.1886303,
0.3858062,
0.03680915,
0.01391892,
0.2044306,
0.4166738,
-0.03613641,
-0.1039271,
-0.1322597,
-0.2789699,
-0.01280315,
0.2277888,
-0.1024794,
0.3334102,
0.2460739,
0.1241667,
-0.1024531,... |
Ten weeks of aerobic training does not result in persistent changes in VLDL triglyceride turnover or oxidation in healthy men. | Very low density lipoprotein triglyceride (VLDL-TG) and free fatty acids (FFA) constitute a substantial proportion of human energy supply both at rest and during exercise. Exercise acutely decreases VLDL-TG concentration, and VLDL-TG clearance is increased after an exercise bout. However, the effects of long-term train... | 25,117,466 | [
-0.007136183,
0.2288962,
-0.3861247,
-0.1643455,
0.1444121,
-0.1639515,
-0.1059379,
0.07847826,
-0.1105235,
0.03349041,
0.1735887,
-0.1357902,
-0.1000275,
-0.1807507,
-0.3130083,
-0.4224475,
-0.39974,
0.1733545,
-0.1956373,
0.3184239,
-0.3122676,
0.2449155,
-0.07701848,
... |
Identification of threshold prostate specific antigen levels to optimize the detection of clinically significant prostate cancer by magnetic resonance imaging/ultrasound fusion guided biopsy. | Prostate specific antigen sensitivity increases with lower threshold values but with a corresponding decrease in specificity. Magnetic resonance imaging/ultrasound targeted biopsy detects prostate cancer more efficiently and of higher grade than standard 12-core transrectal ultrasound biopsy but the optimal population ... | 25,117,476 | [
-0.08650979,
0.1197681,
-0.1063466,
-0.1360481,
-0.2477334,
-0.4518387,
-0.08246429,
0.1979558,
0.2173506,
0.04932122,
0.02117774,
-0.07898138,
0.202095,
-0.4083006,
-0.5188223,
-0.1239873,
-0.2426875,
-0.05913837,
0.05660441,
-0.2567045,
-0.07685424,
0.2521065,
-0.040181... |
Correlation of gross urine color with diagnostic findings in male cats with naturally occurring urethral obstruction. | Seventy-five male cats with urethral obstruction were prospectively enrolled to evaluate gross urine color at urinary catheter placement for correlation with diagnostic findings. Cats with darker red urine were more likely to be azotemic (serum creatinine concentration >2.0 mg/dl [177 µmol/l]), and urine color corre... | 25,117,491 | [
0.03887967,
0.4730939,
-0.1963293,
-0.1254369,
-0.2459217,
-0.07726391,
-0.07411972,
-0.06088249,
-0.02750369,
-0.006501791,
0.3035081,
0.2652257,
-0.01550872,
0.3211974,
0.1880907,
0.1151103,
-0.4513609,
0.1309559,
0.3162006,
-0.6905608,
-0.1407196,
-0.0943294,
-0.166592... |
Advantages of crystallographic fragment screening: functional and mechanistic insights from a powerful platform for efficient drug discovery. | X-ray crystallography has been an under-appreciated screening tool for fragment-based drug discovery due to the perception of low throughput and technical difficulty. Investigators in industry and academia have overcome these challenges by taking advantage of key factors that contribute to a successful crystallographic... | 25,117,499 | [
0.01224842,
0.2876674,
0.127657,
-0.1355546,
-0.05775536,
-0.1420306,
-0.1694655,
0.2636874,
0.1968313,
-0.2416761,
0.06022814,
-0.001054225,
0.09155483,
0.09930267,
-0.3888235,
0.1958815,
-0.2046513,
-0.1513443,
-0.1143794,
0.2468126,
0.2319689,
0.05793019,
-0.1145443,
... |
Building safety into active living initiatives. | Efforts to promote environmental designs that facilitate opportunities for physical activity should consider the fact that injuries are the leading cause of death for Americans ages 1 to 44, with transportation-related injuries the most common cause. Drawing on the latest research and best practices in the field of inj... | 25,117,526 | [
-0.4116403,
0.201369,
-0.2979046,
-0.07803906,
0.0172355,
0.08654787,
-0.2112752,
-0.0582218,
0.2479104,
-0.1429335,
-0.01273489,
-0.2779187,
-0.0481109,
-0.04277197,
-0.293338,
0.09327596,
-0.4478504,
0.06152051,
-0.0936379,
0.04154101,
-0.2014778,
0.3479231,
-0.103351,
... |
Endophytic fungi: expanding the arsenal of industrial enzyme producers. | Endophytic fungi, mostly belonging to the Ascomycota, are found in the intercellular spaces of the aerial plant parts, particularly in leaf sheaths, sometimes even within the bark and root system without inducing any visual symptoms of their presence. These fungi appear to have a capacity to produce a wide range of enz... | 25,117,531 | [
-0.02793757,
0.0103989,
0.1299438,
0.1853936,
-0.1049263,
-0.1537964,
0.00940561,
-0.04476158,
0.02615883,
0.1933658,
0.001905119,
-0.4244165,
-0.06736603,
0.1883684,
-0.251222,
0.3586175,
-0.6162665,
0.4535954,
0.3232373,
-0.2130895,
0.2594665,
0.4845712,
-0.2168066,
-... |
Label-free colorimetric detection of cadmium ions in rice samples using gold nanoparticles. | A simple and label-free colorimetric method for cadmium ions (Cd(2+)) detection using unmodified gold nanoparticles (AuNPs) is reported. The unmodified AuNPs easily aggregate in a high concentration of NaCl solution, but the presence of glutathione (GSH) can prevent the salt-induced aggregation of AuNPs. When Cd(2+) is... | 25,117,533 | [
0.1443781,
0.305973,
-0.01043345,
0.09661815,
-0.03023546,
-0.04695297,
-0.3312166,
0.07641347,
0.08302978,
0.01740621,
-0.02758828,
0.3073447,
0.1552083,
0.1599066,
0.0513793,
0.1189565,
-0.7477528,
0.2019065,
0.1414887,
-0.1103193,
0.4174487,
0.2225007,
-0.2105958,
0.... |
The energy allocation function of sleep: a unifying theory of sleep, torpor, and continuous wakefulness. | The energy allocation (EA) model defines behavioral strategies that optimize the temporal utilization of energy to maximize reproductive success. This model proposes that all species of the animal kingdom share a universal sleep function that shunts waking energy utilization toward sleep-dependent biological investment... | 25,117,535 | [
0.07801049,
0.1904186,
-0.2727018,
-0.2127504,
-0.0343662,
-0.5152469,
-0.1385361,
-0.3801824,
0.08004245,
-0.1289238,
-0.09311479,
-0.1926443,
-0.03757755,
0.02506988,
-0.4566922,
-0.01571342,
-0.9100327,
-0.1936183,
0.2174154,
-0.162852,
-0.1659734,
0.2930434,
-0.194952... |
First report of a direct surface plasmon resonance immunosensor for a small molecule seafood toxin. | Tetrodotoxin (TTX), a small molecular weight neurotoxin, is responsible for poisoning events that traditionally occur from consumption of contaminated puffer fish. Recent studies have shown a growing number of foods contaminated with TTX and a larger number of waters and associated countries where the toxin may occur. ... | 25,117,539 | [
-0.006098697,
-0.1606091,
0.09592926,
0.07138471,
-0.02548156,
0.1576815,
-0.06059809,
0.2863316,
0.173375,
-0.2263159,
0.2938316,
-0.04332836,
-0.03425086,
-0.159558,
-0.1324522,
0.07213031,
-0.5464018,
0.2451475,
0.2278076,
-0.1006338,
0.09609702,
0.1961267,
-0.2198624,... |
Polyethylenimine carbon nanotube fiber electrodes for enhanced detection of neurotransmitters. | Carbon nanotube (CNT)-based microelectrodes have been investigated as alternatives to carbon-fiber microelectrodes for the detection of neurotransmitters because they are sensitive, exhibit fast electron transfer kinetics, and are more resistant to surface fouling. Wet spinning CNTs into fibers using a coagulating poly... | 25,117,550 | [
-0.1578182,
0.04396737,
-0.2820366,
-0.09989976,
-0.061741,
0.07472437,
-0.1165472,
0.211989,
0.09806747,
-0.1411652,
0.2835872,
0.02541503,
0.06877135,
-0.06830273,
-0.01370535,
-0.08433992,
-0.5653737,
0.1907853,
0.2749647,
-0.094841,
0.04126674,
0.2268492,
-0.008735079... |
Reference gene selection for quantitative real-time PCR normalization in Reaumuria soongorica. | Despite its superiority for evaluating gene expression, real-time quantitative polymerase chain reaction (qPCR) results can be significantly biased by the use of inappropriate reference genes under different experimental conditions. Reaumuria soongorica is a dominant species of desert ecosystems in arid central Asia. G... | 25,117,551 | [
0.223047,
0.2379513,
0.1258772,
-0.1757756,
-0.0728446,
0.06604278,
-0.04789576,
-0.2081957,
0.1718039,
-0.09007479,
0.1398193,
-0.2359529,
-0.09127741,
0.1444337,
-0.1143549,
0.1542917,
-0.1989823,
0.1601114,
-0.1455799,
0.2018993,
0.1309263,
0.07574489,
-0.308352,
0.0... |
Engineering bacterial microcompartment shells: chimeric shell proteins and chimeric carboxysome shells. | Bacterial microcompartments (BMCs) are self-assembling organelles composed entirely of protein. Depending on the enzymes they encapsulate, BMCs function in either inorganic carbon fixation (carboxysomes) or organic carbon utilization (metabolosomes). The hallmark feature of all BMCs is a selectively permeable shell for... | 25,117,559 | [
0.09072168,
0.03011734,
-0.05193362,
-0.08787081,
-0.04069377,
-0.2605455,
-0.07581459,
0.1798373,
0.2214245,
-0.06118392,
0.1552731,
0.06340618,
-0.1518708,
0.2171457,
-0.4117914,
0.1125819,
-0.3048048,
-0.2382776,
0.06786282,
-0.0602873,
-0.02964536,
0.1019655,
0.055766... |
Secretoglobin 3A2 attenuates lipopolysaccharide-induced inflammation through inhibition of ERK and JNK pathways in bronchial epithelial cells. | Secretoglobin (SCGB) 3A2, previously known as uteroglobin-related protein 1, is a secreted protein highly expressed in the epithelial cells of the airways. It has been demonstrated that SCGB3A2 is involved in allergic airway inflammation such as bronchial asthma. However, the role of SCGB3A2 in lipopolysaccharide (LPS)... | 25,117,566 | [
0.2220331,
-0.2764014,
-0.3377651,
-0.1876467,
-0.1196222,
0.255374,
-0.241849,
-0.2124929,
0.09716236,
-0.1285074,
0.06938951,
-0.1355841,
-0.2375294,
-0.539636,
0.09460755,
0.3743421,
-0.07317677,
0.01924787,
0.07180924,
-0.2266229,
0.03023516,
0.2040895,
-0.1938846,
... |
Interleukin-6 and other inflammatory markers in diagnosis of periprosthetic joint infection. | The purpose of this study was to evaluate the diagnostic value of interleukin-6 (IL-6) and other inflammatory markers including C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and white blood cell count (WCC) in diagnosis of PJI. The study group included 40 patients (21 males, 19 females) admitted for s... | 25,117,573 | [
0.2394414,
-0.3421216,
-0.1641942,
-0.1653191,
-0.09557719,
-0.256117,
-0.1569298,
0.4215893,
-0.1104601,
-0.1754592,
0.07340354,
0.2983747,
-0.02949603,
0.1755924,
-0.05417408,
-0.2381843,
-0.06234743,
0.4408955,
0.02443878,
0.0626565,
-0.04568589,
-0.1582288,
-0.0619028... |
Prevalence of femoro-acetabular impingement in international competitive track and field athletes. | The aim of our study was to analyse the prevalence of femoro-acetabular impingement (FAI) in national elite track and field athletes compared to peers using magnetic resonance imaging (MRI) and clinical examination including impingement tests. A total of 44 participants (22 national elite track and field athletes and 2... | 25,117,575 | [
-0.3386029,
0.09300393,
0.2737704,
0.06250507,
0.204371,
-0.3865407,
-0.2969189,
0.136635,
-0.3819227,
-0.04772568,
-0.15653,
0.3126319,
0.1500468,
-0.3407439,
-0.07838479,
-0.4341339,
-0.0609066,
0.5000169,
-0.1660416,
-0.1606922,
-0.04732554,
-0.09278277,
-0.1915938,
... |
Effect of multilevel laboratory rat caging system on the well-being of the singly-housed Sprague Dawley rat. | Current regulations emphasize that good husbandry practices allow animals to engage in species appropriate postural adjustments without touching the enclosure walls. This study evaluated the well-being of rats housed in a commercially available multilevel rat caging system, with or without access to the upper level of ... | 25,117,586 | [
0.2606443,
0.3677061,
-0.1907933,
-0.3573818,
0.1716064,
-0.5625485,
-0.2445997,
-0.06282189,
-0.159535,
-0.2383257,
-0.1491655,
-0.3030777,
0.1360071,
0.1544864,
-0.1624915,
0.1965377,
-0.4510501,
0.1570532,
0.2053968,
-0.03251614,
-0.5713521,
0.4348563,
0.2295136,
-0.... |
Urodynamics before stress urinary incontinence surgery. | In patients with symptoms of stress urinary incontinence, there is still a debate regarding the benefit of a multichannel urodynamic investigation prior to surgical management. The purpose of this article is to review recent evidence on this topic. Results of two large randomized controlled trials provided evidence tha... | 25,117,607 | [
0.01643183,
0.2988193,
-0.09718347,
-0.3549803,
0.1448661,
-0.345579,
-0.249421,
-0.2230804,
0.06219834,
0.07208888,
0.2505542,
0.1171904,
-0.1786023,
-0.247203,
-0.122239,
-0.1244355,
-0.02732318,
0.2784982,
-0.3597443,
-0.3810161,
0.09686407,
0.1559996,
-0.005889207,
... |
Phase-1 study of abiraterone acetate in chemotherapy-naïve Japanese patients with castration-resistant prostate cancer. | Persistent androgen synthesis under castration status in adrenal gland, testes and tumor cells is thought to be one of the major causes of development and progression of castration-resistant prostate cancer (CRPC). Abiraterone acetate (AA), the prodrug of abiraterone, which is an inhibitor of androgen synthesis enzymes... | 25,117,615 | [
-0.17502,
0.08639902,
-0.04870596,
-0.4911596,
-0.2185724,
-0.3326695,
-0.1271785,
0.5136926,
0.3245879,
-0.2643279,
0.1516706,
-0.1802341,
0.1329561,
0.05324541,
-0.4742529,
-0.06053566,
-0.3165855,
-0.01931379,
0.1337766,
0.2856978,
0.1494684,
0.2158409,
-0.09929753,
... |
Transforming growth factor alpha is a critical mediator of radiation lung injury. | Radiation fibrosis of the lung is a late toxicity of thoracic irradiation. Epidermal growth factor (EGF) signaling has previously been implicated in radiation lung injury. We hypothesized that TGF-α, an EGF receptor ligand, plays a key role in radiation-induced fibrosis in lung. Mice deficient in transforming growth fa... | 25,117,621 | [
0.2327205,
-0.5201324,
-0.1511162,
-0.08146842,
-0.05400972,
-0.118249,
-0.05506831,
-0.0540465,
-0.0320192,
0.02721546,
-0.134113,
0.2331999,
-0.257974,
-0.2062636,
-0.168858,
0.1483527,
0.3352464,
0.06491397,
0.0327826,
0.4578581,
-0.07995734,
0.2983442,
-0.1826312,
0... |
Modeling dose deposition and DNA damage due to low-energy β(-) emitters. | One of the main issues of low-energy internal emitters concerns the very short ranges of the beta particles, versus the dimensions of the biological targets. Depending on the chemical form, the radionuclide may be more concentrated either in the cytoplasm or in the nucleus of the target cell. Consequently, since in mos... | 25,117,624 | [
-0.1066395,
0.02962289,
-0.01175393,
0.2811137,
0.2335972,
-0.09389114,
-0.2641796,
-0.02944308,
0.3097101,
0.5488959,
-0.1773026,
-0.4820359,
0.1278365,
0.2467066,
-0.4957091,
-0.2624464,
0.1775998,
0.1331846,
0.0837413,
0.3918161,
0.3341788,
0.5863135,
0.07999372,
-0.... |
Hierarchically porous three-dimensional electrodes of CoMoO₄ and ZnCo₂O₄ and their high anode performance for lithium ion batteries. | Ternary metal oxides have been receiving wide attention in electrochemical energy storage due to their rich redox reactions and tuneable conductivity. We present a simple solution-based method to prepare a 3D interconnected porous network of ternary metal oxide (CoMoO₄ and ZnCo₂O₄) nanostructures on macroporous nickel ... | 25,117,647 | [
0.01778987,
0.2830915,
0.1381016,
0.1913005,
0.03317972,
-0.3171366,
-0.5224939,
-0.05072244,
-0.1997816,
-0.1148404,
-0.1438067,
-0.2907842,
-0.02422305,
0.4603359,
-0.7752261,
-0.2509937,
-0.2365102,
0.2278692,
-0.06488638,
0.1599517,
0.095011,
0.1538967,
-0.150623,
0... |
Oxidative stress and antioxidant status in patients with autoimmune liver diseases. | To estimate oxidative stress and antioxidant components during different stages of autoimmune liver diseases and assess their possible implication on disease progression. We determined several markers of oxidative injury (isoprostane, aldehydes, protein carbonyls, 3-nitrotyrosine, and myeloperoxidase) and antioxidant c... | 25,117,650 | [
-0.3401912,
0.1083279,
-0.001056315,
-0.1818838,
-0.07184994,
-0.1406341,
-0.02769538,
0.290557,
0.0705794,
0.2174055,
0.1181086,
-0.02103682,
-0.004234305,
0.08953407,
-0.1960369,
-0.1583096,
-0.5151707,
0.1481741,
-0.07117403,
0.2458255,
-0.5471399,
0.09509385,
-0.38701... |
Systemic lupus erythematosus-associated acute transverse myelitis: manifestations, treatments, outcomes, and prognostic factors in 20 patients. | Transverse myelitis is a rare complication of systemic lupus erythematosus (SLE). This retrospective multicentre study identifies the prognostic factors in a relatively large patient series. Twenty patients fulfilled the SLE criteria of the ACR classification and the Transverse Myelitis Consortium Working Group. A seve... | 25,117,654 | [
0.07263628,
-0.176261,
0.180507,
-0.3142023,
-0.164633,
-0.3318725,
-0.01666867,
-0.01146024,
-0.3751202,
-0.07115209,
-0.2134343,
-0.2949975,
0.3043152,
0.06443957,
0.02635277,
-0.1881139,
0.02862619,
0.008428136,
-0.1273946,
0.01049085,
-0.08508815,
-0.001392446,
-0.206... |
Utilization of stem cells to treat congenital heart disease: hype and hope. | Surgical advances over the past few decades have transformed the clinical management of congenital heart disease, such as hypoplastic left heart syndrome. Congenital heart disease affects more than 1% of liveborn infants and accounts for more than 2.5 million affected children per year worldwide. The cost and availabil... | 25,117,663 | [
-0.2925067,
-0.1351644,
-0.2715265,
0.09915776,
-0.04181787,
-0.07621482,
0.1233478,
0.2937837,
0.2817069,
0.3981068,
0.05327412,
0.3168692,
-0.3328929,
-0.108183,
-0.434346,
-0.05348441,
-0.3236789,
-0.1653125,
-0.05356721,
-0.09909646,
0.0268751,
0.3461883,
-0.2798111,
... |
Genetic variation in dihydropyrimidine dehydrogenase (DPYD) gene in a healthy adult Indian population. | Dihydropyrimidine dehydrogenase (DPD) encoded by DPYD gene is the major enzyme involved in metabolism of 5-flurouracil (5-FU), a pyrimidine analogue used in cancer chemotherapy. Although very effective as a cancer therapeutic drug, if not rapidly metabolized, 5-FU may prove lethal. Single nucleotide variants (SNVs) wit... | 25,117,664 | [
-0.2962759,
-0.2384072,
0.1134923,
-0.0892072,
0.2421592,
-0.2427989,
0.1276539,
0.1864892,
0.05503035,
-0.2209452,
0.1945966,
0.1734381,
-0.1626519,
-0.01979904,
-0.1034092,
-0.3524739,
-0.1983549,
0.3566031,
0.2699637,
0.06942288,
0.01018766,
0.5003319,
-0.05681606,
-... |
Silencing of microRNA-122 is an early event during hepatocarcinogenesis from non-alcoholic steatohepatitis. | Non-alcoholic steatohepatitis (NASH) has emerged as a common cause of chronic liver disease and virus-independent hepatocellular carcinoma (HCC) in patients with obesity, diabetes, and metabolic syndrome. To reveal the molecular mechanism underlying hepatocarcinogenesis from NASH, microRNA (miRNA) expression profiles w... | 25,117,675 | [
-0.309561,
0.1050619,
0.04187545,
-0.09139388,
0.0544636,
0.06909543,
0.1112596,
0.04120146,
0.2503927,
0.1471579,
-0.1818213,
0.08703781,
-0.0008526913,
0.1336814,
-0.4898938,
0.01198856,
0.0346835,
0.2452703,
0.3320653,
-0.1434095,
-0.1241678,
0.07442751,
-0.3714645,
... |
Closing the gap between glia and neuroblast proliferation. | Reporting in this issue of Developmental Cell, Spéder and Brand (2014) show that gap junctions are required in blood-brain barrier glial cells to reactivate proliferation of quiescent neuroblasts. Gap junctions allow synchronous Ca(2+) waves and control insulin-like protein Dipl6 expression and secretion to trigger neu... | 25,117,678 | [
-0.2469739,
-0.3605865,
-0.166617,
-0.2052558,
0.2153702,
-0.0900704,
-0.2918659,
-0.07942203,
0.2673907,
-0.02338376,
-0.01407067,
0.1621417,
-0.1903384,
-0.1983219,
-0.8362883,
0.04158256,
-0.5889512,
-0.1199148,
-0.09064814,
-0.04826889,
0.1802644,
0.0006218914,
0.1234... |
A role for β3-integrins in linking breast development and cancer. | Pregnancy induces a rapid and controlled expansion of mammary stem cells. In this issue of Developmental Cell, Desgrosellier et al. (2014) show that β3-integrin is required downstream of hormonal signaling and TGFβ2 to regulate mammary stem cell number and alveolar development specifically during early pregnancy. | 25,117,679 | [
0.141579,
-0.05737184,
-0.2028289,
-0.2685329,
0.008246928,
-0.1694475,
-0.1180432,
0.227933,
-0.03937268,
0.3249528,
0.0421125,
0.1377961,
-0.1639551,
-0.2931326,
-0.1828013,
-0.2756643,
-0.2324019,
-0.05782231,
0.2509908,
-0.1520873,
0.3252191,
0.1900354,
-0.1207142,
... |
N-cadherin locks left-right asymmetry by ending the leftward movement of Hensen's node cells. | The stereotypic left-right (LR) asymmetric distribution of internal organs is due to an asymmetric molecular cascade in the lateral plate mesoderm (LPM) that is originated at the embryonic node. In chicken embryos, molecular asymmetries at Hensen's node are created by leftward cell movements that occur transiently. Wha... | 25,117,685 | [
-0.1547051,
0.145305,
-0.2859411,
-0.3327508,
0.0556557,
-0.01913578,
-0.3819106,
-0.1486804,
0.006044017,
-0.1418478,
-0.1454437,
0.5916783,
-0.05121944,
-0.3207361,
-0.1564255,
-0.04178089,
-0.3855097,
-0.07280976,
-0.1879267,
-0.03202706,
0.2432321,
0.2412209,
-0.20092... |
YAPping about differentiation therapy in muscle cancer. | Overcoming a presumed differentiation block in the childhood muscle cancer embryonal rhabdomyosarcoma is often thought to hold promise as an approach to replace cytotoxic chemotherapy with molecularly-targeted differentiation therapies. In this issue of Cancer Cell, Tremblay and colleagues implicate YAP1 and the Hippo ... | 25,117,705 | [
-0.08774168,
0.2099436,
-0.1534392,
-0.4795145,
-0.02227536,
-0.1518478,
-0.2328919,
0.0912517,
0.02198111,
0.1924498,
0.2452825,
0.2697258,
-0.2401016,
-0.09188385,
-0.5621285,
0.01446947,
-0.361175,
0.06123054,
-0.2159518,
0.08138792,
0.3599656,
0.02135974,
-0.2081034,
... |
Multiparametric magnetic resonance imaging for the differentiation of low and high grade clear cell renal carcinoma. | To retrospectively evaluate the ability of magnetic resonance (MR) imaging to differentiate low from high Fuhrman grade renal cell carcinoma (RCC). MR images from 80 consecutive pathologically proven RCC (57 clear cell, 16 papillary and 7 chromophobe) were evaluated. Double-echo chemical shift, dynamic contrast-enhance... | 25,117,747 | [
0.2233831,
0.02702248,
0.02794801,
-0.378274,
0.18203,
-0.6163643,
-0.04766211,
0.3770744,
-0.2831378,
0.3373826,
0.06313212,
0.3181956,
-0.131176,
-0.1099519,
-0.760651,
-0.4767362,
-0.4245137,
0.2338904,
0.05024121,
-0.008236903,
-0.1498094,
0.1710359,
-0.5214959,
0.0... |
Seasonal variations of vitamin D concentrations in pregnant women and neonates in Slovenia. | While foreign research shows a high prevalence of vitamin D deficiency in pregnant women and consequently in neonates, we do not have any data on vitamin D concentration in these risk groups for Slovenia. We performed a prospective study to evaluate vitamin D concentration in pregnant women and neonates in Maribor regi... | 25,117,752 | [
-0.2447551,
-0.304232,
-0.2670121,
0.09728786,
0.1155156,
-0.1129693,
-0.3928618,
0.08801357,
0.006759043,
0.0672299,
0.1825964,
0.2142575,
0.06069702,
-0.2446731,
-0.2615246,
-0.2854629,
-0.1632332,
0.3576845,
-0.02216963,
0.2818758,
0.2980788,
0.452063,
-0.1022154,
0.... |
Disease-specific T-helper cell polarizing function of lesional dendritic cells in different types of chronic rhinosinusitis with nasal polyps. | Although eosinophilic and noneosinophilic chronic rhinosinusitis with nasal polyps (CRSwNP) exhibit distinct T-helper (Th) responses, the underlying mechanisms remain unclear. To clarify the phenotypes and Th-cell polarizing functions of dendritic cells (DCs) in different types of CRSwNP. DC subsets, their surface phen... | 25,117,756 | [
0.04219219,
-0.1539208,
-0.1945161,
-0.2198936,
0.0613009,
-0.3001004,
-0.07481971,
0.124466,
-0.1463023,
0.1690818,
-0.1782256,
-0.2177502,
-0.03673248,
-0.3870422,
-0.3826461,
0.3344874,
-0.1176765,
0.1165996,
0.01634998,
0.1543423,
-0.0479752,
0.1462125,
-0.2366457,
... |
Predictors of health-related quality of life over time among adolescents and young adults with sickle cell disease. | Little is known about what factors affect the health-related quality of life (HRQoL) of adolescents and young adults (AYAs) with sickle cell disease (SCD), and how their HRQoL changes over time. This retrospective study included 87 AYAs attending a SCD Adolescent Clinic who completed a measure of HRQoL at each visit ov... | 25,117,764 | [
-0.1300361,
-0.2037994,
-0.5901689,
-0.1404735,
-0.1800215,
-0.09131815,
-0.2825876,
0.2138718,
-0.280485,
-0.1690744,
0.1424751,
0.4625846,
-0.4108631,
-0.2716025,
-0.0529532,
-0.04466883,
-0.158715,
0.06777,
0.4231831,
0.04818417,
0.03778127,
0.0408771,
-0.1271875,
0.... |
A short peptide from frog skin accelerates diabetic wound healing. | Delayed wound healing will result in the development of chronic wounds in some diseases, such as diabetes. Amphibian skins possess excellent wound-healing ability and represent a resource for prospective wound-healing promoting compounds. A potential wound-healing promoting peptide (CW49; amino acid sequence APFRMGICTT... | 25,117,795 | [
0.1578234,
-0.3328609,
-0.3913762,
0.0003111483,
0.1667808,
0.1442072,
-0.1446806,
0.2742842,
0.6885692,
-0.3463522,
-0.3387033,
-0.059189,
0.03581887,
-0.2287177,
-0.1045004,
0.01919656,
-0.1735371,
0.2529896,
0.1563288,
-0.1907112,
-0.1948411,
0.09984511,
-0.3347759,
... |
The selective adsorption of tellurium in the aluminosilicate regions of AFI- and MOR-type microporous crystals. | Attempts have been made to load tellurium (Te) atoms into the one-dimensional nano-channels of microporous crystals of aluminophosphate AlPO4-5 and of aluminosilicate mordenites of the Na(+) form (Na-MOR) and the H(+)-form (H-MOR) at 673 K. The density of the atoms adsorbed was in the sequence 0 ∼ AlPO4-5 ≪ H-MOR < ... | 25,117,797 | [
-0.1622478,
-0.1050722,
-0.1392067,
0.1929854,
-0.01701351,
-0.1141625,
-0.2742538,
-0.1448043,
-0.1285539,
-0.3468739,
-0.1525542,
-0.306509,
0.1131441,
0.03287479,
-0.2731822,
-0.3245369,
-0.4554952,
0.4592615,
0.1469369,
-0.08577226,
0.03367372,
0.09312362,
-0.00435315... |
Identification of 33 candidate oncogenes by screening for base-specific mutations. | Genes with recurrent codon-specific somatic mutations are likely drivers of tumorigenesis and potential therapeutic targets. Hypermutable cancers may represent a sensitive system for generation and selection of oncogenic mutations. We utilised exome-sequencing data on 25 sporadic microsatellite-instable (MSI) colorecta... | 25,117,815 | [
-0.1325205,
-0.410041,
-0.329538,
-0.2260931,
-0.05762073,
-0.1409529,
-0.2118348,
0.2400375,
0.1453888,
-0.2590836,
-0.0284796,
0.1811106,
0.3609179,
0.1032383,
-0.3047394,
-0.1504074,
-0.561536,
-0.2160171,
0.2631276,
0.03044585,
-0.06414461,
0.4628689,
-0.04925323,
0... |
Person-to-person transmission of norovirus resulting in an outbreak of acute gastroenteritis at a summer camp. | A significant proportion of norovirus (NV) gastroenteritis outbreaks described in the Spanish literature have been because of contaminated food or water. This study describes an outbreak of acute gastroenteritis because of NV in which there was person-to-person transmission. A retrospective cohort study was carried out... | 25,117,826 | [
-0.4875263,
0.03852028,
-0.08771311,
-0.3575867,
0.1069908,
-0.3794814,
-0.2130173,
-0.1079148,
-0.1328319,
-0.3776828,
0.1497709,
-0.08318706,
-0.01233071,
-0.2310395,
-0.1473554,
-0.4830866,
-0.214552,
0.1337326,
-0.0506828,
-0.04256436,
-0.03509646,
0.04431839,
-0.1776... |
Species variation in the enantioselective metabolism of tegafur to 5-fluorouracil among rats, dogs and monkeys. | Tegafur (FT), a pro-drug of 5-fluorouracil (5-FU), is a racemate consisting of two enantiomers, R and S-FT. The aim of this study was to clarify interspecies variation in the enantioselective metabolism of FT. Plasma concentrations of FT enantiomers were determined in rats, dogs and monkeys following intravenous and or... | 25,117,829 | [
-0.3838531,
0.1095817,
-0.5902988,
-0.3803366,
0.07317023,
-0.3144614,
0.2368093,
-0.09028946,
-0.1589788,
-0.2782247,
0.3219904,
-0.1852048,
0.1156861,
0.3397989,
-0.4803233,
-0.1230789,
-0.4455738,
0.05489528,
0.1546526,
0.2072145,
-0.2804797,
0.3322333,
-0.3448431,
0... |
Laparoscopic myomectomy: clinical outcomes and comparative evidence. | Laparoscopic myomectomy is a common surgical treatment for symptomatic uterine leiomyomas. Proponents of the laparoscopic approach to myomectomy propose that the advantages include shorter length of hospital stay and recovery time. Others suggest longer operative time, greater blood loss, increased risk of recurrence, ... | 25,117,840 | [
-0.1002477,
0.05982203,
-0.3925321,
-0.4073876,
-0.1826975,
-0.1873972,
-0.1128317,
-0.205434,
0.1008639,
0.04751897,
-0.1223106,
-0.1065403,
-0.003485409,
-0.1462668,
-0.1747795,
-0.2984725,
-0.1551658,
0.05398548,
0.1846731,
-0.2977295,
-0.152413,
0.3297387,
-0.2107732,... |
A latent growth curve analysis of alcohol-use specific parenting and adolescent alcohol use. | This study investigates how changes in alcohol use-specific parenting were associated with adolescent drinking trajectories. Three waves of data from a longitudinal study investigating adolescent substance use were used. The community sample (N=378) was aged 10-13 at the first wave of assessment. Our findings show that... | 25,117,845 | [
-0.04104184,
0.1959111,
-0.4608707,
-0.2588868,
0.2740578,
-0.1586706,
-0.396081,
-0.1650996,
-0.1262639,
-0.2473576,
-0.02300661,
-0.1409726,
-0.1214595,
-0.1318431,
0.1396704,
0.2159649,
-0.05538246,
0.5634585,
0.1087895,
0.002588217,
0.3068919,
0.1702593,
0.1034241,
... |
The emerging trend of work beyond retirement age in Germany. Increasing social inequality? | Population ageing, demographic change and the financial crisis has put the financial sustainability of the German pension system at risk. In reaction to these challenges, Germany recently abandoned generous early retirement policies and moved towards policies encouraging higher employment among the elderly. In this art... | 25,117,859 | [
0.2295312,
0.08595578,
0.08587873,
0.1882676,
0.1897946,
-0.2189358,
0.1119245,
0.1700296,
-0.1924019,
0.2752893,
0.01722608,
-0.3927281,
0.03760316,
0.02240023,
-0.1931345,
-0.1155889,
0.3207049,
0.1100911,
-0.03705351,
-0.1847805,
0.184819,
0.4358722,
0.05924834,
0.00... |
Effect of electrohydraulic shockwave treatment on tenderness, muscle cathepsin and peptidase activities and microstructure of beef loin steaks from Holstein young bulls. | Hydrodynamic pressure processing (HDP) or shockwave treatment improved tenderness (18% reduction in Warner-Bratzler shear force (WBSF) of beef loin steaks. Endogenous muscle proteolyic activities (cathepsins and peptidases) and protein fragmentation of sarcoplasmic and myofibrillar proteins detected by sodium dodecyl s... | 25,117,876 | [
0.07461888,
0.3041753,
0.1310431,
0.2192291,
0.1329862,
-0.4756995,
-0.01876129,
-0.4461712,
0.387056,
-0.03082227,
0.2208121,
-0.01588652,
-0.1428079,
-0.3918915,
-0.2431818,
0.1273087,
-0.4471424,
-0.1530318,
-0.1971847,
-0.3374157,
-0.08958409,
0.1278201,
-0.2943292,
... |
School-level factors associated with increased fruit and vegetable consumption among students in California middle and high schools. | This study assessed associations between selective school-level factors and students' consumption of fruits and vegetables at school. Better understanding of school factors associated with increased produce consumption is especially important, as students are served more produce items at school. This cross-sectional st... | 25,117,889 | [
-0.1688256,
0.2393796,
-0.2868521,
-0.02757093,
0.2147662,
-0.0646035,
-0.1609402,
0.4461151,
0.05678627,
-0.1895056,
0.02840274,
-0.1100981,
-0.008541604,
-0.2801947,
-0.2263486,
-0.3148722,
0.09920047,
0.265253,
0.0971617,
-0.1550687,
0.213014,
0.4022482,
0.06977459,
... |
The placebo effect in early-phase glaucoma clinical trials. | To analyze the extent and prevalence of the placebo effect in prior early-phase glaucoma clinical studies. Articles were evaluated on phase I and II trials of glaucoma medicines that became commercially available after 1977 with a placebo arm that involved glaucoma patients. We included 23 studies with 23 treatment arm... | 25,117,918 | [
-0.2829687,
0.1887461,
-0.4592291,
-0.337095,
-0.01042995,
-0.08668099,
-0.2464912,
0.07911805,
0.3088709,
-0.5252711,
-0.03615007,
0.04765081,
0.0957505,
-0.1518061,
-0.1816983,
-0.1628655,
-0.02203804,
0.4460801,
-0.0100376,
0.08839462,
-0.02011078,
0.3869461,
-0.051472... |
Can trained volunteers make a difference at mealtimes for older people in hospital? A qualitative study of the views and experience of nurses, patients, relatives and volunteers in the Southampton Mealtime Assistance Study. | Malnutrition is common amongst hospitalised older patients and associated with increased morbidity and mortality. Poor dietary intake results from factors including acute illness and cognitive impairment but additionally patients may have difficulty managing at mealtimes. Use of volunteers to help at mealtimes is rarel... | 25,117,920 | [
-0.3625768,
0.1476001,
-0.2852886,
-0.2791496,
0.2633169,
-0.2757343,
0.02656726,
-0.4190426,
0.1392074,
-0.1079053,
-0.06363679,
0.04961469,
-0.3255692,
-0.1972747,
-0.266319,
-0.05796594,
-0.3176892,
-0.1061372,
-0.4202946,
-0.03941784,
-0.2280948,
0.2249456,
0.00964943... |
HIV and noncommunicable diseases (NCDs) in Latin America: a call for an integrated and comprehensive response. | The life expectancy of people living with HIV has dramatically improved with the much increased access to antiretroviral therapy. Consequently, a larger number of people living with HIV are living longer and facing the increased burden of noncommunicable diseases (NCDs). NCDs and HIV infection share common epidemiologi... | 25,117,966 | [
-0.09964749,
-0.09194306,
0.3740609,
0.1263565,
0.09912821,
0.05554417,
0.08182212,
0.08803447,
0.0821299,
0.1191642,
0.06031505,
-0.06591025,
-0.1388304,
-0.06566547,
-0.3179809,
-0.2826118,
-0.1704603,
0.147278,
-0.03719975,
-0.04323729,
0.07215739,
0.2660287,
-0.235964... |
Bacteriocins: Recent Trends and Potential Applications. | In the modern era, there is great need for food preservation in both developing and developed countries due to increasing demand for extending shelf life and prevention of spoilage of food material. With the emergence of new pathogens and ability of micro-organisms to undergo changes, exploration of new avenues for the... | 25,117,970 | [
-0.2727705,
-0.1794714,
0.2405991,
0.004816908,
-0.0621405,
-0.245261,
-0.2902117,
0.2281971,
0.1823851,
-0.2900345,
-0.09330814,
-0.1853723,
-0.005935098,
0.03686488,
-0.2199624,
-0.2687102,
-0.3017421,
0.1316887,
0.3194354,
-0.160826,
0.0103558,
0.466684,
-0.3085283,
... |
Enteral nutrition within 72 h after onset of acute pancreatitis vs delayed initiation. | To explore early (within 72 h) vs delayed enteral nutrition (EN) therapy for patients with acute pancreatitis (AP). A total of 93 patients were allocated to two groups: early enteral nutrition (EEN) group (started within 72 h after onset) and delayed enteral nutrition (DEN) group (started beyond 72 h but within 7 days ... | 25,117,988 | [
0.03047969,
-0.1734094,
0.08990148,
-0.03120873,
0.03885722,
-0.1777235,
0.2481155,
0.1488203,
0.1232884,
0.160768,
-0.04209097,
-0.1613028,
-0.028673,
0.3511865,
0.0529194,
-0.3750452,
-0.3573491,
0.1495863,
-0.05511356,
-0.08659206,
-0.2468203,
0.2874895,
-0.1401497,
... |
Associations of sugar-containing beverages with asthma prevalence in 11-year-old children: the PIAMA birth cohort. | Recently, a few studies have linked soft drink consumption to increased asthma risk, but the contribution of different types of soft drinks is unknown. We investigated cross-sectional associations between six different types of soft drinks and asthma in 11-year-old children. We analyzed data of 2406 children participat... | 25,117,998 | [
-0.009065831,
0.2419959,
-0.05277964,
0.09038708,
0.1261948,
-0.1467734,
-0.3455977,
0.1061571,
0.0557869,
-0.4825677,
0.1637156,
0.01184417,
0.2299834,
-0.5645348,
-0.1626168,
-0.05593735,
-0.06655251,
0.2475398,
0.2008467,
-0.006019427,
0.3708955,
0.2262666,
-0.3932665,... |
In vitro anticancer activity of loquat tea by inducing apoptosis in human leukemia cells. | Fresh loquat leaves have been used as folk health herb in Asian countries for long time, although the evidence supporting their functions is still minimal. This study aimed to clarify the chemopreventive effect of loquat tea extract (LTE) by investigating the inhibition on proliferation, and underlying mechanisms in hu... | 25,118,018 | [
-0.2745786,
0.2229665,
0.144047,
0.3152013,
0.2190509,
0.06666368,
-0.07533631,
-0.09330152,
0.1771404,
-0.1213945,
-0.06594717,
0.4367862,
0.1030428,
0.3713664,
-0.262418,
0.1002743,
-0.6467262,
0.2549415,
-0.19243,
0.05843845,
0.4340841,
0.5770786,
-0.2209171,
0.20521... |
Increased methylation of the MOR gene proximal promoter in primary sensory neurons plays a crucial role in the decreased analgesic effect of opioids in neuropathic pain. | The analgesic potency of opioids is reduced in neuropathic pain. However, the molecular mechanism is not well understood. The present study demonstrated that increased methylation of the Mu opioid receptor (MOR) gene proximal promoter (PP) in dorsal root ganglion (DRG) plays a crucial role in the decreased morphine ana... | 25,118,039 | [
0.1732542,
-0.04774381,
0.05333985,
-0.1003816,
-0.05755714,
0.03754155,
-0.07926327,
0.0782202,
0.1282979,
-0.1283589,
0.3438087,
0.1009514,
-0.09305906,
0.1985108,
0.02816238,
-0.1943439,
-0.5383682,
0.1219733,
0.132723,
0.08598213,
0.006738441,
0.1777372,
0.05418137,
... |
Of early animals, anaerobic mitochondria, and a modern sponge. | The origin and early evolution of animals marks an important event in life's history. This event is historically associated with an important variable in Earth history - oxygen. One view has it that an increase in oceanic oxygen levels at the end of the Neoproterozoic Era (roughly 600 million years ago) allowed animals... | 25,118,050 | [
-0.2185534,
-0.009126281,
0.09321302,
0.2007476,
-0.2931374,
-0.368337,
-0.1517384,
-0.07201758,
0.1902338,
-0.1542774,
-0.09956053,
0.1118633,
0.05361335,
-0.3013465,
-0.7867754,
-0.2805691,
-0.1964869,
-0.00679523,
0.006497777,
0.01359344,
0.1247866,
0.1687187,
-0.12448... |
Fitness for entering a simple exercise program and mortality: a study corollary to the exercise introduction to enhance performance in dialysis (EXCITE) trial. | In this corollary analysis of the EXCITE study, we looked at possible differences in baseline risk factors and mortality between subjects excluded from the trial because non-eligible (n=216) or because eligible but refusing to participate (n=116). Baseline characteristics and mortality data were recorded. Survival and ... | 25,118,055 | [
-0.4275837,
0.1142932,
-0.139808,
0.1177812,
-0.006540074,
-0.8589717,
-0.0825517,
0.2476572,
-0.1970076,
-0.03288081,
-0.2538802,
0.08278345,
0.03943889,
0.1703652,
-0.1275187,
0.0615593,
-0.1029398,
-0.06071347,
0.1746873,
0.3306664,
-0.2401744,
0.3100362,
-0.2334509,
... |
Synchronous tRNA movements during translocation on the ribosome are orchestrated by elongation factor G and GTP hydrolysis. | The translocation of tRNAs through the ribosome proceeds through numerous small steps in which tRNAs gradually shift their positions on the small and large ribosomal subunits. The most urgent questions are: (i) whether these intermediates are important; (ii) how the ribosomal translocase, the GTPase elongation factor G... | 25,118,068 | [
-0.2014365,
0.2671917,
-0.6177116,
-0.2041614,
0.07825762,
-0.4637672,
-0.1016922,
0.01370758,
0.1213829,
0.05737324,
-0.0299847,
-0.07924608,
-0.08375983,
-0.05753865,
0.009574021,
-0.04743693,
-0.3253326,
-0.1109135,
0.01060325,
-0.06818002,
0.2557812,
0.04839615,
-0.07... |
Viunalikeviruses are environmentally common agents of horizontal gene transfer in pathogens and biocontrol bacteria. | Bacteriophages have been used as natural biocontrol and therapeutic agents, but also as biotechnological tools for bacterial engineering. We showed recently that the transducing bacteriophage ϕMAM1 is a ViI-like phage and a member of the new genus, 'Viunalikevirus'. Here, we show that four additional ViI-like phages an... | 25,118,075 | [
-0.3169215,
0.09230382,
-0.1272352,
-0.2978124,
0.03156199,
-0.11592,
-0.1573333,
0.3201418,
0.08086541,
-0.1096632,
-0.03877699,
0.05942791,
0.2086964,
-0.1049599,
-0.4077038,
-0.001864705,
-0.4354683,
0.0003506515,
0.4349241,
0.06056522,
0.1881376,
0.2820585,
-0.3490389... |
The quantified patient: a patient participatory culture. | The Quantified Self Movement, which aims to improve various aspects of life and health through recording and reviewing daily activities and biometrics, is a new and upcoming practice of self monitoring that holds much promise. Now, the most underutilized resource in ambulatory health care, the patient, can participate ... | 25,118,077 | [
-0.2804764,
0.01386208,
-0.3688375,
-0.2418265,
-0.2202842,
0.01771365,
-0.2728015,
-0.01271272,
0.0009644041,
-0.35486,
0.004856515,
-0.1504829,
-0.04107688,
-0.5091561,
-0.4142589,
0.1293284,
-0.4793417,
0.1877162,
-0.245241,
0.07427558,
0.03033006,
0.01354191,
-0.04409... |
Reboxetine adjuvant therapy in patients with schizophrenia showing a suboptimal response to clozapine: a 12-week, open-label, pilot study. | The present 12-week open-label uncontrolled trial was aimed to explore the efficacy of reboxetine add-on pharmacotherapy on clinical symptoms and cognitive functioning in 15 patients with schizophrenia with suboptimal response (mean [SD] Brief Psychiatric Rating Scale baseline total score, 32.2 [5.4]) despite receiving... | 25,118,083 | [
0.0379488,
0.3809176,
-0.005288041,
-0.05296374,
0.1729322,
-0.4657932,
-0.2952181,
-0.01514954,
-0.05062374,
-0.1204062,
0.2710319,
0.1006636,
0.05864102,
0.2295507,
-0.0190886,
-0.1527299,
-0.08887774,
-0.03612879,
-0.07037914,
0.1156625,
-0.3509457,
0.1944054,
-0.07544... |
The rise of mortality from mental and neurological diseases in Europe, 1979-2009: observational study. | We studied recent trends in mortality from seven mental and neurological conditions and their determinants in 41 European countries. Age-standardized mortality rates were analysed using standard methods of descriptive epidemiology, and were related to cultural, economic and health care indicators using regression analy... | 25,118,099 | [
-0.1237338,
-0.1500474,
0.009274535,
-0.3075841,
-0.04007119,
-0.1124079,
-0.203488,
-0.2026202,
-0.2465909,
0.05066821,
-0.2164057,
-0.08176681,
0.1963456,
-0.06916752,
0.05655408,
-0.003586673,
0.2474135,
0.3879356,
0.09076969,
0.3343193,
0.2342407,
0.4228708,
-0.222357... |
Bipolar disorder and its relation to major psychiatric disorders: a family-based study in the Swedish population. | Bipolar disorder (BPD) shares genetic components with other psychiatric disorders; however, uncertainty remains about where in the psychiatric spectra BPD falls. To understand the etiology of BPD, we studied the familial aggregation of BPD and co-aggregation between BPD and schizophrenia, depression, anxiety disorders,... | 25,118,125 | [
-0.01714132,
0.04532291,
-0.006490748,
0.3709925,
0.1897353,
-0.4636626,
-0.1754462,
-0.1237576,
-0.1354583,
0.2642287,
-0.05359996,
0.03006498,
0.1364138,
0.1497734,
-0.08356573,
0.1615962,
-0.187831,
0.4995749,
0.02708763,
-0.1136239,
0.1961108,
0.3011577,
0.03293226,
... |
Use of psychotherapy in a representative adult community sample in São Paulo, Brazil. | Little is known about the use of psychotherapy to treat common mental disorders in a major city in a middle-income country. Our data come from in-home interviews with a stratified random sample of 2000 community residents aged 18 to 65 years in the city of São Paulo, Brazil. The information obtained included sociodemog... | 25,118,139 | [
-0.265644,
0.414652,
0.2466972,
0.1125569,
0.1900989,
-0.1598907,
-0.4697318,
-0.1932659,
-0.1569071,
-0.2018594,
0.4526056,
0.03524664,
-0.1562478,
-0.04607128,
-0.3063429,
-0.232296,
0.005792401,
0.1831747,
-0.1109748,
-0.07476615,
0.07915112,
0.1476219,
-0.08588142,
... |
Effects of earthworms on physicochemical properties and microbial profiles during vermicomposting of fresh fruit and vegetable wastes. | This study aimed to investigate the effect of earthworms on physicochemical and microbial properties during vermicomposting of fresh fruit and vegetable wastes (FVW) by contrasting two decomposing systems of FVW with and without earthworms for 5weeks. Compared to control treatment (without earthworms), vermicomposting ... | 25,118,152 | [
0.00460431,
0.3593509,
-0.07963997,
-0.1617943,
0.05591693,
-0.2601032,
-0.1025303,
0.2071487,
0.07148496,
-0.104501,
-0.05191652,
-0.2983731,
-0.2379002,
-0.1969391,
-0.3274574,
0.1064461,
-0.3947158,
0.2076242,
-0.09742646,
0.03809088,
0.003002747,
0.5997455,
0.03537951... |
Co-inheritance of α-thalassaemia and β-thalassaemia in a prenatal screening population in mainland China. | To determine the prevalence of α-thalassaemia in β-thalassaemia individuals in a Chinese population. The standard diagnostic marker for β-thalassaemia was elevation of the Hb A2 level (>3.5%) with low mean corpuscular volume. The common α-thalassaemia mutations were studied by molecular analysis in all identified β-... | 25,118,159 | [
0.0968482,
0.09849828,
0.177731,
0.2908747,
0.09467759,
-0.190696,
-0.1469203,
0.06438003,
0.2571282,
0.05617847,
0.06672373,
0.5649664,
-0.2022456,
0.04548333,
0.04285136,
-0.4029833,
-0.3219865,
-0.03881869,
0.05996367,
-0.1321517,
0.5441357,
0.3930022,
-0.08015588,
0... |
Type II cytokines impair host defense against an intracellular fungal pathogen by amplifying macrophage generation of IL-33. | Interleukin (IL)-4 subverts protective immunity to multiple intracellular pathogens, including the fungus Histoplasma capsulatum. Previously, we reported that H. capsulatum-challenged CCR2(-/-) mice manifest elevated pulmonary fungal burden owing to exaggerated IL-4. Paradoxical to our anticipation in IL-33 driving IL-... | 25,118,166 | [
0.009744361,
-0.2253207,
-0.06472691,
-0.2264511,
0.1670968,
-0.1767108,
-0.05769364,
0.2684804,
-0.001377136,
0.1044075,
-0.0316104,
-0.09031915,
-0.1114892,
-0.147983,
-0.0741735,
-0.01567783,
-0.1643165,
-0.2885608,
-0.1519525,
-0.02968862,
-0.1116944,
0.1480368,
-0.16... |
A high-density genetic map for soybean based on specific length amplified fragment sequencing. | Soybean is an important oil seed crop, but very few high-density genetic maps have been published for this species. Specific length amplified fragment sequencing (SLAF-seq) is a recently developed high-resolution strategy for large scale de novo discovery and genotyping of single nucleotide polymorphisms. SLAF-seq was ... | 25,118,194 | [
0.1924952,
0.2849405,
0.3794109,
0.1080877,
0.5554165,
-0.1448854,
-0.02620901,
-0.0246311,
0.1846906,
-0.09092651,
-0.08657869,
0.03713011,
0.0719611,
-0.3662652,
-0.2504819,
-0.2181406,
-0.3414871,
-0.02038282,
0.3938681,
-0.02403376,
0.2664231,
0.4116202,
-0.2729189,
... |
20 years of leptin: leptin and reproduction: past milestones, present undertakings, and future endeavors. | The association between leptin and reproduction originated with the leptin-mediated correction of sterility in ob/ob mice and initiation of reproductive function in normal female mice. The uncovering of a central leptin pathway regulating food intake prompted the dissection of neuroendocrine mechanisms involving leptin... | 25,118,207 | [
0.08480369,
-0.2621196,
0.2258701,
0.05285152,
0.2299424,
-0.4637162,
0.0334847,
-0.006189412,
0.2975796,
-0.03409917,
0.02595419,
0.03742934,
0.0327474,
-0.2211425,
-0.6204505,
-0.4212298,
-0.1454481,
0.06766523,
0.1465801,
-0.20215,
0.005336053,
0.3581577,
-0.204299,
... |
Proteome-wide light/dark modulation of thiol oxidation in cyanobacteria revealed by quantitative site-specific redox proteomics. | Reversible protein thiol oxidation is an essential regulatory mechanism of photosynthesis, metabolism, and gene expression in photosynthetic organisms. Herein, we present proteome-wide quantitative and site-specific profiling of in vivo thiol oxidation modulated by light/dark in the cyanobacterium Synechocystis sp. PCC... | 25,118,246 | [
0.3419724,
-0.1088973,
0.03445031,
0.09066317,
-0.2034959,
-0.01771875,
0.2538892,
0.2368775,
0.2546842,
-0.336615,
0.0941974,
0.1349538,
-0.09604337,
0.08582091,
0.117879,
0.240072,
-0.6194274,
-0.1236532,
0.02271212,
-0.1398229,
0.05099824,
0.4631758,
-0.1226012,
0.13... |
RESTORE: REcovery after Serious Trauma--Outcomes, Resource use and patient Experiences study protocol. | Traumatic injury is a leading contributor to the overall global burden of disease. However, there is a worldwide shortage of population data to inform understanding of non-fatal injury burden. An improved understanding of the pattern of recovery following trauma is needed to better estimate the burden of injury, guide ... | 25,118,259 | [
-0.0849712,
-0.2878244,
-0.0312983,
-0.1800489,
-0.4202211,
-0.3078144,
-0.03192313,
0.01915114,
0.002136171,
0.06898586,
-0.02052193,
0.00257108,
-0.07366779,
-0.01617578,
-0.08685915,
0.03497461,
-0.08447754,
0.1849717,
-0.2707149,
0.05192377,
-0.1856432,
0.1474054,
-0.... |
A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase. | Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are a promising class of antiretroviral agents for clinical development. Although ALLINIs promote aberrant IN multimerization and inhibit IN interaction with its cellular cofactor LEDGF/p75 with comparable potencies in vitro, their primary mechanism of action in infe... | 25,118,283 | [
-0.2406417,
0.5069413,
-0.3515908,
0.06430391,
0.1819655,
0.1770759,
-0.003235976,
0.2677191,
0.5979449,
-0.1499906,
0.1200167,
-0.2745907,
-0.1462334,
0.09576467,
-0.463698,
0.1546845,
-0.2937896,
-0.06352808,
-0.392682,
0.2778381,
0.05992595,
0.5082485,
-0.07628809,
0... |
Predictive markers of radiotherapy-induced rectal cancer regression. | Patients with locally advanced rectal cancer receive preoperative radiotherapy to reduce the probability of recurrence and to possibly improve overall survival. However, this appears dependent on the extent of histological tumour regression seen in the resected bowel, which can be highly variable between individuals. N... | 25,118,294 | [
0.06268867,
-0.2889231,
-0.08300322,
-0.2546605,
-0.1214148,
-0.4431984,
0.05255035,
0.03858788,
0.2418424,
0.07511608,
0.1271108,
0.05631901,
0.2539683,
-0.22471,
-0.2825163,
-0.09636743,
-0.4162196,
0.08053982,
0.1284822,
0.2733908,
-0.1667045,
0.08409616,
-0.3036363,
... |
Effects of different levels of pressure support on intra-individual breath-to-breath variability. | Evidence exists that during pressure support ventilation (PSV), the addition of an extrinsic (ie, ventilator-generated) breath-to-breath variability (BBV) of breathing pattern improves respiratory function. If BBV is beneficial per se, choosing the PS level that maximizes it could be considered a valid strategy for con... | 25,118,312 | [
-0.1087622,
-0.05326926,
-0.3831606,
-0.1674159,
0.0792172,
-0.09746137,
0.08041628,
-0.2792712,
-0.168186,
0.04352873,
0.1445204,
-0.219791,
-0.319279,
-0.3951306,
-0.1781123,
-0.1358204,
-0.533685,
-0.1724908,
-0.1793143,
0.1985212,
-0.2179234,
-0.1656411,
0.0198793,
... |
Low-dose CT for patients with clinically suspected acute appendicitis: optimal strength of sinogram affirmed iterative reconstruction for image quality and diagnostic performance. | As there is increased concern over the radiation exposure particularly in adolescents and young adults, computed tomography (CT) dose reduction is needed in the diagnosis of acute appendicitis. To evaluate the optimal strength of sinogram affirmed iterative reconstruction (SAFIRE) to obtain the best image quality on a ... | 25,118,330 | [
-0.05927651,
0.3510561,
-0.06703185,
-0.1377125,
-0.01912497,
-0.127233,
-0.268722,
-0.2440242,
0.2489284,
-0.471673,
-0.1157813,
-0.2352326,
-0.1463969,
-0.2411467,
0.04018278,
-0.2988422,
-0.7281922,
-0.08545189,
-0.1523265,
0.1234769,
0.1020124,
-0.03083522,
0.0919214,... |
[Genetic characteristics of influenza A/H3N2 virus neuraminidase gene: a survey from 2010 to 2012 in Qinghai Province, China]. | This study aims to perform a survey of genetic variation in neuraminidase (NA) gene of influenza A/H3N2 virus, as well as related resistance to NA inhibitors, in Qinghai Province of China, 2010 to 2012. Strains of influenza A/H3N2 isolated during an influenza survey from 2010 to 2012 in Qinghai were enrolled by random ... | 25,118,381 | [
-0.1707282,
0.1889194,
-0.3474742,
0.2151365,
-0.08100449,
-0.1130857,
-0.2013664,
0.03751237,
-0.1912544,
-0.3991851,
0.4144003,
0.03162036,
0.1319429,
-0.2827722,
0.1873994,
-0.1786054,
0.1302462,
0.1953231,
0.2659211,
0.1545138,
0.4332629,
0.3999577,
-0.4071914,
-0.0... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.