title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Who are the children using hospice care? | The purpose was to examine the characteristics of children who use hospice care. Using the Andersen Model of Health Services Use, California Medicaid administrative databases were analyzed to describe the characteristics of 76 children in hospice. The predisposing, enabling, and need characteristics of children were id... | 25,131,751 | [
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A heterogeneous hierarchy of co-regulatory receptors regulates exhaustion of HCV-specific CD8 T cells in patients with chronic hepatitis C. | The functionality of virus-specific T cells is regulated by a sophisticated network of an expanding repertoire of co-regulatory receptors, which could be harnessed for immunotherapeutic applications. However, targeting particular pathways during persistent virus infections has resulted in variable outcomes. The extent ... | 25,131,771 | [
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Hepatic fungal infection in a young beagle with unrecognised hereditary cobalamin deficiency (Imerslund-Gräsbeck syndrome). | A 12-month-old beagle presented for anorexia, pyrexia and vomiting. The dog had been treated intermittently with antibiotics and corticosteroids for inappetence and lethargy since five months of age. Previous laboratory abnormalities included macrocytosis and neutropenia. At presentation, the dog was lethargic, febrile... | 25,131,805 | [
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Phylogenetic analysis of fowl adenoviruses isolated from chickens with gizzard erosion in Japan. | Thirty-four fowl adenoviruses (FAdVs) isolated from chickens with gizzard erosion (GE) from 1999 to 2010 were characterized phylogenetically together with foreign isolates. The phylogenetic analysis based on part of the hexon gene classified these 34 FAdV isolates into 3 groups: FAdV-1, -8a and 8b, thereby suggesting t... | 25,131,809 | [
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Effect of passive polarizing three-dimensional displays on surgical performance for experienced laparoscopic surgeons. | Although the potential benefits of stereoscopic laparoscopy have been recognized for years, the technology has not been adopted because of poor operator tolerance. Passive polarizing projection systems, which have revolutionized three-dimensional (3D) cinema, are now being trialled in surgery. This study was designed t... | 25,131,843 | [
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Complete remission of VZV reactivation treated with valganciclovir in a patient with total lymphocyte depletion and acute kidney injury after allogeneic bone marrow transplantation. | Varicella zoster virus (VZV), a threat for hematopoietic stem cell transplantation (HSCT) recipients, is still one of the most common viral pathogens that affect these patients with a reported incidence ranging between 17% and 50% in the post transplantation period. Valganciclovir (V-GCV), a valine ester pro-drug of GC... | 25,131,855 | [
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Expression, purification, and micelle reconstitution of antimicrobial piscidin 1 and piscidin 3 for NMR studies. | Piscidin 1 and piscidin 3, which were discovered in the mast cells of hybrid striped sea bass, are homologous antimicrobial peptides that are active against drug-resistant bacteria. Piscidin 1, the more antimicrobial and hemolytic peptide, also has anti-HIV-1 and anti-cancer properties. To understand the reasons underl... | 25,131,859 | [
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Expression and biochemical characterization of recombinant human epididymis protein 4. | Whey acidic proteins (WAP) belong to a large gene family of antibacterial peptides that perform critical immune system functions. The function of human epididymis protein 4 (HE4), a 124-amino acid long polypeptide that has two whey acidic protein four-disulfide core (WFDC) domains, is not well studied. Here, a fusion g... | 25,131,860 | [
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[The efficacy and safety of FOLFIRI or combined FOLFIRI and bevacizumab treatment as second-line chemotherapy for metastatic colorectal cancer patients aged 75 years and older]. | The safety and efficacy of FOLFIRI as second-line chemotherapy for metastatic colorectal cancer patients ≥ 75 years was retrospectively evaluated. We analyzed 106 patients, who received FOLFIRI or a combination of FOLFIRI and bevacizumab following oxaliplatin-based first-line chemotherapy. The clinical characteristics ... | 25,131,872 | [
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[Successful treatment of advanced sigmoid colon cancer with liver metastases with cetuximab monotherapy as first-line treatment-a case report]. | The prognosis for patients diagnosed with advanced colorectal cancer with liver metastases is poor. Chemotherapy should be administered with caution in such patients because of complications due to severe liver dysfunction. We report here the successful management of a case of advanced sigmoid colon cancer, with icteru... | 25,131,880 | [
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A cold-induced myo-inositol transporter-like gene confers tolerance to multiple abiotic stresses in transgenic tobacco plants. | A full length cDNA encoding a myo-inositol transporter-like protein, named as MfINT-like, was cloned from Medicago sativa subsp. falcata (herein falcata), a species with greater cold tolerance than alfalfa (M. sativa subsp. sativa). MfINT-like is located on plasma membranes. MfINT-like transcript was induced 2-4 h afte... | 25,131,886 | [
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Geographical comparisons of information and support needs of Australian women following the primary treatment of breast cancer: a 10-year replication study. | In 2002, Raupach and Hiller examined the use of and satisfaction with information and support following treatment of breast cancer from a sample of participants in South Australia. In 2013 this study was replicated to include participants Australia wide and analyse comparisons based on geographical location. Statistica... | 25,131,899 | [
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Effects of salpingectomy and antituberculosis treatments on fertility results in patients with genital tuberculosis. | The aim of this study was to demonstrate the effects of tubal surgery and antituberculosis treatments in patients with genital tuberculosis. A total of 38 infertile women who had been diagnosed with pelvic tuberculosis and who had had laparoscopy and hysteroscopy were recruited into the study. All women with female gen... | 25,131,900 | [
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Appetite predicts mortality in free-living older adults in association with dietary diversity. A NAHSIT cohort study. | This study aimed to assess the predictive ability of appetite for mortality among representative free-living Taiwanese older adults. A total of 1856 participants aged 65 years or over from the Elderly Nutrition and Health Survey during 1999-2000 completed an appetite question in a larger questionnaire. Personal informa... | 25,131,903 | [
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PTX3: a modulator of human coronary plaque vulnerability acting by macrophages type 2. | Acute myocardial infarction (AMI), is related to a diffuse active inflammation of the coronary tree associated with rupture of one of the multiple vulnerable plaques. The presence of soluble mediators of inflammation with their synergic or antagonistic actions coordinates the physiological response determining the plaq... | 25,131,923 | [
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Severe autonomic failure as a predictor of mortality in aortic valve stenosis. | Identification of new risk markers in aortic valve stenosis (AS) is of great interest. Here, we hypothesized that the presence of severe autonomic failure (SAF) is an important prognostic marker in both, symptomatic patients undergoing invasive treatment for severe AS, and in asymptomatic patients with severe AS who we... | 25,131,928 | [
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Protective effect of the herbal preparation, STW 5, against intestinal damage induced by gamma radiation in rats. | STW 5 (marketed as Iberogast(®), Steigerwald Arzneimittelwerk GmbH, Darmstadt, Germany) is a herbal preparation reported to possess anti-inflammatory properties and antioxidant activity. We investigated the effect of STW 5 against intestinal injury induced after whole body exposure to ionizing radiation (IR). Intestina... | 25,131,937 | [
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Transcript elongation factors: shaping transcriptomes after transcript initiation. | Elongation is a dynamic and highly regulated step of eukaryotic gene transcription. A variety of transcript elongation factors (TEFs), including modulators of RNA polymerase II (RNAPII) activity, histone chaperones, and histone modifiers, have been characterized from plants. These factors control the efficiency of tran... | 25,131,948 | [
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Imatinib mesylate plus hydroxyurea chemotherapy for cerebellar meningioma in a Belgian Malinois dog. | An 8-year-old intact male Belgian Malinois, weighing 37.2 kg, was referred for evaluation due to right side facial paresis, ataxia and a 2-month history of decreased cognitive ability. Physical and neurological examinations revealed mild depression, left-sided head tilt, right-sided facial paresis and ataxia. A well-de... | 25,131,949 | [
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Triglycerides and cardiovascular disease. | After the introduction of statins, clinical emphasis first focussed on LDL cholesterol-lowering, then on the potential for raising HDL cholesterol, with less focus on lowering triglycerides. However, the understanding from genetic studies and negative results from randomised trials that low HDL cholesterol might not ca... | 25,131,982 | [
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Gallic acid regulates skin photoaging in UVB-exposed fibroblast and hairless mice. | Ultraviolet (UV) radiation is the primary factor in skin photoaging, which is characterized by wrinkle formation, dryness, and thickening. The mechanisms underlying skin photoaging are closely associated with degradation of collagen via upregulation of matrix metalloproteinase (MMP) activity, which is induced by reacti... | 25,131,997 | [
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Clinical and molecular characteristics of community-acquired methicillin-resistant Staphylococcus aureus infections in Chinese neonates. | This study aims to characterize the clinical features of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections in Chinese neonates, as well as the molecular characteristics and expression of key virulence genes of isolates. Clinical information and molecular characteristics of 130 cases we... | 25,132,016 | [
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Heritability of head motion during resting state functional MRI in 462 healthy twins. | Head motion (HM) is a critical confounding factor in functional MRI. Here we investigate whether HM during resting state functional MRI (RS-fMRI) is influenced by genetic factors in a sample of 462 twins (65% female; 101 MZ (monozygotic) and 130 DZ (dizygotic) twin pairs; mean age: 21 (SD = 3.16), range 16-29). Heritab... | 25,132,021 | [
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[Maintenance therapy for advanced non-small-cell lung cancer]. | Maintenance therapy is a new treatment strategy for advanced non-small-cell lung cancer(NSCLC), and it consists of switch maintenance and continuation maintenance.Switch maintenance is the introduction of a different drug, not included as part of the induction therapy, immediately after completion of 4 cycles of first-... | 25,132,023 | [
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[Gallbladder cancer with elevated serum α-fetoprotein, α-fetoprotein-L3, and human chorionic gonadotropin levels]. | A 61-year-old woman presented with fever and was diagnosed with choledocholithiasis, which was removed endoscopically. Incidentally, a markedly elevated serum α-fetoprotein(AFP)level was detected(1,951 ng/mL), but computed tomography( CT)showed only diffuse gallbladder wall thickening. Subsequently, markedly elevated s... | 25,132,038 | [
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The development of a classification schema for arts-based approaches to knowledge translation. | Arts-based approaches to knowledge translation are emerging as powerful interprofessional strategies with potential to facilitate evidence uptake, communication, knowledge, attitude, and behavior change across healthcare provider and consumer groups. These strategies are in the early stages of development. To date, no ... | 25,132,050 | [
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Effect of lithium chloride on the production and sialylation of Fc-fusion protein in Chinese hamster ovary cell culture. | Lithium chloride (LiCl), which is a specific inhibitor of glycogen synthase kinase-3β, is known to induce cell cycle arrest at the G2/M phase and to regulate apoptosis. To determine the potential of LiCl as a chemical additive to enhance specific productivity (q p) of recombinant Chinese hamster ovary (rCHO) cells thro... | 25,132,065 | [
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Efficacy of catheter ablation for persistent atrial fibrillation: a systematic review and meta-analysis of evidence from randomized and nonrandomized controlled trials. | Catheter ablation (CA) is commonly performed for persistent atrial fibrillation, but few high-quality randomized controlled trials (RCTs) exist, leading to funding restrictions being proposed in several countries. We performed a random-effects meta-analysis of RCTs and non-RCTs to assess the efficacy of CA for persiste... | 25,132,078 | [
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Mitochondrial macro-haplogroup JT may play a protective role in ovarian ageing. | This study of 200 Caucasian women shows that the distribution of the mtDNA macro-haplogroups in patients with diminished ovarian reserve (DOR) differed significantly from that of patients with normal ovarian reserve (NOR) (p=0.02). The JT macro-haplogroup was significantly under-represented in DOR patients compared wit... | 25,132,080 | [
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Structural mapping of divergent regions in the type 1 ryanodine receptor using fluorescence resonance energy transfer. | Ryanodine receptors (RyRs) release Ca(2+) to initiate striated muscle contraction. Three highly divergent regions (DRs) in the RyR protein sequence (DR1, DR2, and DR3) may confer isoform-specific functional properties to the RyRs. We used cell-based fluorescence resonance energy transfer (FRET) measurements to localize... | 25,132,084 | [
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Crystal structures of designed armadillo repeat proteins: implications of construct design and crystallization conditions on overall structure. | Designed armadillo repeat proteins (dArmRP) are promising modular proteins for the engineering of binding molecules that recognize extended polypeptide chains. We determined the structure of a dArmRP containing five internal repeats and 3rd generation capping repeats in three different states by X-ray crystallography: ... | 25,132,085 | [
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Efficacy of concurrent cetuximab vs. 5-fluorouracil/carboplatin or high-dose cisplatin with intensity-modulated radiation therapy (IMRT) for locally-advanced head and neck cancer (LAHNSCC). | We previously reported inferior outcomes for locally-advanced head and neck squamous cell carcinoma (LAHNSCC) patients treated with concurrent cetuximab vs. high-dose cisplatin with intensity-modulated radiation therapy (IMRT). Prior to FDA approval of cetuximab for LAHNSCC, non-cisplatin eligible patients at our insti... | 25,132,089 | [
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FrxA is an S-nitrosoglutathione reductase enzyme that contributes to Helicobacter pylori pathogenicity. | Helicobacter pylori is a pathogen that infects the gastric mucosa of a large percentage of the human population worldwide, and predisposes to peptic ulceration and gastric cancer. Persistent colonization of humans by H. pylori triggers an inflammatory response that leads to the production of reactive nitrogen species. ... | 25,132,107 | [
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Efficient solar cells sensitized by porphyrins with an extended conjugation framework and a carbazole donor: from molecular design to cosensitization. | Porphyrin dyes containing the carbazole electron donor have been designed and optimized by wrapping the porphyrin framework, introducing an additional ethynylene bridge to extend the wavelength range of light absorption, and further suppression of the dye aggregation by introducing additional alkoxy chains. Application... | 25,132,108 | [
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Quantification of the statistical effects of spatiotemporal processing of nontask FMRI data. | Nontask functional magnetic resonance imaging (fMRI) has become one of the most popular noninvasive areas of brain mapping research for neuroscientists. In nontask fMRI, various sources of "noise" corrupt the measured blood oxygenation level-dependent signal. Many studies have aimed to attenuate the noise in reconstruc... | 25,132,113 | [
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Snacks, beverages, vending machines, and school stores: a comparison of alternative and regular schools in Minnesota, 2002 to 2008. | In US secondary schools, vending machines and school stores are a common source of low-nutrient, energy-dense snacks and beverages, including sugar-sweetened beverages, high-fat salty snacks, and candy. However, little is known about the prevalence of these food practices in alternative schools, which are educational s... | 25,132,120 | [
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Recent advances in germination of Clostridium spores. | Members of Clostridium genus are a diverse group of anaerobic spore-formers that includes several pathogenic species. Their anaerobic requirement enhances the importance of the dormant spore morphotype during infection, persistence and transmission. Bacterial spores are metabolically inactive and may survive for long t... | 25,132,133 | [
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Life history responses of Daphnia similoides simultaneously exposed to microcystin-LR and ammonia and their postexposure recovery. | Aquatic organisms often suffer episodic stress from cyanobacterial bloom-derived concomitants and sometimes interactive stressors, and they may recover when stressors terminate. To assess whether exposed Daphnia can quickly recover from combined toxicity of bloom-derived stressors, Daphnia similoides were exposed to mi... | 25,132,136 | [
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The kinematic relationship between sitting and standing posture and pelvic inclination and its significance to cup positioning in total hip arthroplasty. | The aim of this study is to describe the influence of sitting and standing posture on sagittal pelvic inclination in total hip replacement patients to assist with correct acetabular component positioning. Lateral radiographs of the pelvis and lumbar spine in sitting and standing positions were extracted. Pelvic tilt wa... | 25,132,150 | [
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Reproductive factors and non-Hodgkin lymphoma: a systematic review. | Considerable efforts have been made to elucidate non-Hodgkin lymphoma's (NHL) etiology during the last decades. Some evidence points to an association with reproductive factors, as incidence rates for most NHL subtypes are usually higher in men than in women, and several subtypes express hormonal receptors. Although th... | 25,132,165 | [
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Hi-C analysis in Arabidopsis identifies the KNOT, a structure with similarities to the flamenco locus of Drosophila. | Chromosomes are folded, spatially organized, and regulated by epigenetic marks. How chromosomal architecture is connected to the epigenome is not well understood. We show that chromosomal architecture of Arabidopsis is tightly linked to the epigenetic state. Furthermore, we show how physical constraints, such as nuclea... | 25,132,176 | [
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Theoretical study on molecular structure and vibrational analysis included FT-IR, FT-Raman and UV techniques of 2,4,5-trimethylbenzoic acid (monomer and dimer structures). | Theoretical study on the structural and vibrational analysis of monomer and dimer structures of 2,4,5-trimethylbenzoic acid (2,4,5-TMBA, C₁₀H₁₂O₂) were presented. The geometry of the molecule was fully optimized. The Fourier transform infrared (FT-IR) and the Fourier transform Raman (FT-Raman) spectra of the title mole... | 25,132,184 | [
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A novel treatment for propagated crown fractures. | A major complication after endodontic treatment is persistent pain on biting or chewing. Although unsuccessful endodontic treatment can account for such pain, pain to chewing and biting can also be a result of an unsupported or propagated crown fracture. Crown fractures that extend apically result in deterioration of t... | 25,132,190 | [
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Simultaneous determination of phenolic compounds in Equisetum palustre L. by ultra high performance liquid chromatography with tandem mass spectrometry combined with matrix solid-phase dispersion extraction. | A method based on matrix solid-phase dispersion extraction followed by ultra high performance liquid chromatography with tandem mass spectrometry is presented for the extraction and determination of phenolic compounds in Equisetum palustre. This method combines the high efficiency of matrix solid-phase dispersion extra... | 25,132,205 | [
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Does dexmedetomidine have a cardiac protective effect during non-cardiac surgery? A randomised controlled trial. | This study was designed to determine the effects of dexmedetomidine on perioperative myocardial injury by observing peripheral circulatory changes in response to tracheal intubation and extubation, myocardial enzyme levels, myocardial ischaemia improvements, cardiovascular adverse events and cytokines in patients with ... | 25,132,247 | [
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Identification of a Plasmodium falciparum inhibitor-2 motif involved in the binding and regulation activity of protein phosphatase type 1. | The regulation of Plasmodium falciparum protein phosphatase type 1 (PfPP1) activity remains to be deciphered. Data from homologous eukaryotic type 1 protein phosphatases (PP1) suggest that several protein regulators should be involved in this essential process. One such regulator, named PfI2 based on its primary sequen... | 25,132,288 | [
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Fragmentation of negative ions from N-linked carbohydrates: part 6. Glycans containing one N-acetylglucosamine in the core. | Negative ion collision-induced dissociation (CID) spectra of N-glycans contain many diagnostic ions that provide more structural information than positive ion spectra. EndoH or endoS release of glycans from glycoproteins, as used by many investigators, cleaves glycans between the GlcNAc residues of the chitobiose core ... | 25,132,301 | [
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Synaptic plasticity under learning challenge. | Memory formation requires changes in neuronal networks connectivity based on modifications in strength and number of synapses. The mechanisms driving these changes have been intensively studied, but mostly under naive conditions, i.e. in animals that have not been cognitively challenged. Better characterization of syna... | 25,132,316 | [
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Avian influenza H9N2 subtype in Poland--characterization of the isolates and evidence of concomitant infections. | In April/May 2013, four outbreaks of avian influenza virus (AIV) infections caused by H9N2 subtype were diagnosed in Poland in fattening turkey flocks exhibiting a drop in feed and water intake, depression, respiratory signs and mortality. The subsequent serological survey carried out on samples collected between June ... | 25,132,323 | [
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Melatonin treatment further improves adipose-derived mesenchymal stem cell therapy for acute interstitial cystitis in rat. | This study tests the hypothesis that combined melatonin and adipose-derived mesenchymal stem cell (ADMSC, 1.2 × 10(6) given intravenously) treatment offer superior protection against cyclophosphamide (CYP 150 mg/kg)-induced acute interstitial cystitis (AIC) in rats. Male adult Sprague-Dawley rats were treated as follow... | 25,132,326 | [
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Protective properties of a fusion pneumococcal surface protein A (PspA) vaccine against pneumococcal challenge by five different PspA clades in mice. | An increase in the appearance of nonvaccine serotypes in both children and adults with invasive pneumococcal disease (IPD) after introduction of pneumococcal conjugate vaccine represents a limitation of this vaccine. In this study, we generated three recombinant pneumococcal surface protein A (PspA) proteins comprising... | 25,132,335 | [
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Curcumin attenuates cardiac fibrosis in spontaneously hypertensive rats through PPAR-γ activation. | To investigate the effects of curcumin (Cur) on cardiac fibrosis in spontaneously hypertensive rats (SHRs) and the mechanisms underlying the anti-fibrotic effect of Cur in rat cardiac fibroblasts (CFs) in vitro. SHRs were orally treated with Cur (100 mg·kg(-1)·d(-1)) or Cur (100 mg·kg(-1)·d(-1)) plus the PPAR-γ antagon... | 25,132,338 | [
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Animal models of social anxiety disorder and their validity criteria. | Anxiety disorders pose one of the largest threats to global mental health, and they predominantly emerge early in life. Social anxiety disorder, also known as social phobia, is the most common of all anxiety disorders. Moreover, it has severe consequences and is a disabling disorder that can cause an individual to be u... | 25,132,362 | [
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In-office bleaching gel with 35% hydrogen peroxide enhanced biofilm formation of early colonizing streptococci on human enamel. | To compare the effects of 25% and 35% hydrogen peroxide in-office bleaching systems on surface roughness and streptococcal biofilm formation on human enamel. Enamel specimens (3mm×3mm×2mm, n=162) from human permanent teeth were randomly divided into 3 treatment groups (n=54 each): (1) control, (2) bleached with 25% hyd... | 25,132,364 | [
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... |
Percutaneous carbon dioxide treatment using a gas mist generator enhances the collateral blood flow in the ischemic hindlimb. | Highly concentrated carbon dioxide (CO2) is thought to be useful for ischemic diseases. We investigated whether treatment with a few micrometers of CO2 molecules atomized via two fluidnozzles (CO2 mist) exerts an angiogenic effect in a mouse ischemic hindlimb model. Mice with unilateral hindlimb ischemia were divided i... | 25,132,376 | [
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Closed suction drainage for treatment of septic peritonitis of confirmed gastrointestinal origin in 20 dogs. | To determine survival rate in dogs with septic peritonitis of confirmed gastrointestinal origin treated with closed suction drainage. Retrospective case series. Dogs (n = 20) with septic peritonitis. Medical records (2007-2010) of dogs with septic peritonitis of confirmed gastrointestinal origin treated by closed sucti... | 25,132,380 | [
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Successful management of chronic postsurgical pain following total knee replacement. | We report reversal of chronic postsurgical pain (CPSP) along with functional restoration after total knee replacement (TKR) in two patients, using a combination therapy that included ultrasonography-guided pulsed radiofrequency (PRF) of nerves supplying the knee to provide pain relief, along with dry needling (DN) to r... | 25,132,412 | [
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Beyond the use of modifiers in selective alkyne hydrogenation: silver and gold nanocatalysts in flow mode for sustainable alkene production. | We report on the excellent stereo and chemoselectivity of nanosized silver and gold catalysts in the three-phase hydrogenation of acetylenic compounds under flow chemistry conditions. The materials featuring metal nanoparticles in the range of 2-21 nm were prepared by spray deposition or incipient wetness impregnation ... | 25,132,414 | [
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An analysis of genetic factors related to risk of inflammatory bowel disease and colon cancer. | Patients with inflammatory bowel disease (IBD) have a higher risk of developing colorectal cancer than the general population. Genome-wide association studies have identified and replicated several loci associated with risk of IBD; however, it is currently unknown whether these loci are also associated with colon cance... | 25,132,422 | [
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[A painful occipital mass revealing a posterior encephalocele]. | Encephalocele is a congenital malformation caused by a neural tube defect during embryonic development. We report a case of posterior encephalocele in a 7-month-old infant with a painful occipital mass known since birth. Pathological examination of the mass showed different mature tissues derived from the brain and its... | 25,132,445 | [
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Identification of putative kdr mutations in the tropical bed bug, Cimex hemipterus (Hemiptera: Cimicidae). | Bed bugs [both Cimex hemipterus (F.) and Cimex lectularius L.] are highly resistant to pyrethroids worldwide. An important resistance mechanism known as 'knockdown resistance' (kdr) is caused by genetic point mutations on the voltage-gated sodium channel (VGSC) gene. Previous studies have identified two point mutations... | 25,132,449 | [
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Development of a fluoride chronic effects benchmark for aquatic life in freshwater. | Canada has an interim water-quality guideline for fluoride for protection of freshwater aquatic life that dates from 2002, and 1 Canadian province has a different interim water-quality guideline for fluoride that dates to 1995. The United States does not have a national benchmark for fluoride in freshwater, and only 1 ... | 25,132,451 | [
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The immunology of human cytomegalovirus latency: could latent infection be cleared by novel immunotherapeutic strategies? | While the host immune response following primary human cytomegalovirus (HCMV) infection is generally effective at stopping virus replication and dissemination, virus is never cleared by the host and like all herpesviruses, persists for life. At least in part, this persistence is known to be facilitated by the ability o... | 25,132,454 | [
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Practical knowledge of experienced nurses in critical care: a qualitative study of their narratives. | Scholars of nursing practices have claimed practical knowledge is source of knowledge in its own right, nevertheless we know little about this knowledge associated with day-to-day practice. The purpose of this study is to describe knowledge that the more experienced nurses the in ICU make use of and discover the compon... | 25,132,455 | [
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Desiccation enhances phosphorylation of PSII and affects the distribution of protein complexes in the thylakoid membrane. | Desiccation has significant effects on photosynthetic processes in intertidal macro-algae. We studied an intertidal macro-alga, Ulva sp., which can tolerate desiccation, to investigate changes in photosynthetic performance and the components and structure of thylakoid membrane proteins in response to desiccation. Our r... | 25,132,456 | [
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Lactate dehydrogenase and caspase activity in nasopharyngeal secretions are predictors of bronchiolitis severity. | Bronchiolitis is the leading cause of hospitalization in infants. Biomarkers of disease severity might help in clinical management. To determine the clinical predictiveness of NW-LDH, NW-caspase 3/7, and NW-LDH/NW-caspase 3/7 ratio in bronchiolitis. Previously healthy children less than 24 months of age with bronchioli... | 25,132,512 | [
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Magnetic ring anastomosis of suprahepatic vena cava: novel technique for liver transplantation in rat. | To improve the technique of suprahepatic vena cava (SHVC) reconstruction in rat OLT, novel magnetic rings were designed and manufactured to facilitate reconstruction of SHVC and shorten the anhepatic time. One-hundred and twenty adult male Wistar rats were randomly divided into two groups: rings group (n = 30), using m... | 25,132,515 | [
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Ranolazine attenuates mechanical allodynia associated with demyelination injury. | The aim of this study was to determine whether ranolazine, a new medication that targets sodium channels to improve cardiac ischemia and angina, could be an effective analgesic agent for pain associated with demyelination injury. Many agents have been used to treat neuropathic pain but not all neuropathic conditions re... | 25,132,522 | [
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Hallucigenia's onychophoran-like claws and the case for Tactopoda. | The Palaeozoic form-taxon Lobopodia encompasses a diverse range of soft-bodied 'legged worms' known from exceptional fossil deposits. Although lobopodians occupy a deep phylogenetic position within Panarthropoda, a shortage of derived characters obscures their evolutionary relationships with extant phyla (Onychophora, ... | 25,132,546 | [
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Transcriptional interference by antisense RNA is required for circadian clock function. | Eukaryotic circadian oscillators consist of negative feedback loops that generate endogenous rhythmicities. Natural antisense RNAs are found in a wide range of eukaryotic organisms. Nevertheless, the physiological importance and mode of action of most antisense RNAs are not clear. frequency (frq) encodes a component of... | 25,132,551 | [
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An albumin-based theranostic nano-agent for dual-modal imaging guided photothermal therapy to inhibit lymphatic metastasis of cancer post surgery. | A large variety of cancers are associated with a high incidence of lymph node metastasis, which leads to a high risk of cancer death. Herein, we demonstrate that multimodal imaging guided photothermal therapy can inhibit tumor metastasis after surgery by burning the sentinel lymph nodes (SLNs) with metastatic tumor cel... | 25,132,606 | [
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In vivo 1H MRS of human gallbladder bile at 3 T in one and two dimensions: detection and quantification of major biliary lipids. | In vitro (1)H MRS of human bile has shown potential in the diagnosis of various hepatopancreatobiliary (HPB) diseases. Previously, in vivo (1)H MRS of human bile in gallbladder using a 1.5 T scanner demonstrated the possibility of quantification of choline-containing phospholipids (chol-PLs). However, other lipid compo... | 25,132,620 | [
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Management of the pediatric spontaneous pneumothorax: is primary surgery the treatment of choice? | Surgery as the primary management strategy for pediatric primary spontaneous pneumothorax is controversial. This study aims to evaluate the outcomes and effectiveness of management approaches for pediatric spontaneous pneumothorax. Outcomes of pediatric patients undergoing initial nonoperative treatment versus video-as... | 25,132,627 | [
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Infant perceptual development for faces and spoken words: an integrated approach. | There are obvious differences between recognizing faces and recognizing spoken words or phonemes that might suggest development of each capability requires different skills. Recognizing faces and perceiving spoken language, however, are in key senses extremely similar endeavors. Both perceptual processes are based on r... | 25,132,626 | [
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Cross-sectional evidence for a decrease in cognitive function with age in children with autism spectrum disorders? | Autism spectrum disorders (ASD) are associated with early disturbances in brain maturation processes and these interferences presumably have their consequences for the progressive emergence of cognitive deficits later in life, as expressed in intelligence profiles. In this study, we addressed the impact of age on cogni... | 25,132,666 | [
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Modeling Oral Reading Fluency Development in Latino Students: A Longitudinal Study Across Second and Third Grade. | This study examines growth in oral reading fluency across 2nd and 3rd grade for Latino students grouped in 3 English proficiency levels: students receiving English as a second language (ESL) services (<in</i = 2,182), students exited from ESL services (<in</i = 965), and students never designated as needing services (<... | 25,132,688 | [
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Variable Selection in Generalized Functional Linear Models. | Modern research data, where a large number of functional predictors is collected on few subjects are becoming increasingly common. In this paper we propose a variable selection technique, when the predictors are functional and the response is scalar. Our approach is based on adopting a generalized functional linear mod... | 25,132,690 | [
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Medical universities educational and research online services: benchmarking universities' website towards e-government. | Websites as one of the initial steps towards an e-government adoption do facilitate delivery of online and customer-oriented services. In this study we intended to investigate the role of the websites of medical universities in providing educational and research services following the E-government maturity model in the... | 25,132,713 | [
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Changes in the Muscle Strength of the Elbow Flexors Following a Six-week Experimental Procedure in Adolescents Monitored Through Isokinetic and Motor Tests. | A group of 7 subjects underwent an experimental procedure which studied the potential changes in the maximal strength of the non-dominant arm elbow flexors. The programme duration was limited to 6 weeks during which the subjects practiced exercises 3 times a week, 3 series, on a Scott bench. Individual approach was app... | 25,132,716 | [
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YKL-40 as a novel factor associated with inflammation and catabolic mechanisms in osteoarthritic joints. | YKL-40 is associated with tissue injury and inflammation, and consequently to diseases in which these mechanisms lead to tissue degradation, for example, asthma and rheumatoid arthritis. The purpose of the present study was to investigate if YKL-40 is also a significant factor in osteoarthritis (OA) by assessing associ... | 25,132,728 | [
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Oral administration of herbal mixture extract inhibits 2,4-dinitrochlorobenzene-induced atopic dermatitis in BALB/c mice. | CP001 is four traditional herbal medicine mixtures with anti-inflammatory properties. In this study, we investigated the effect of oral administration of CP001 ethanol extract on the 2,4-dinitrochlorobenzene- (DNCB-) induced AD mouse models. For that purpose, we observed the effects of oral administration of CP001 on s... | 25,132,731 | [
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Hepatitis B virus, HBx mutants and their role in hepatocellular carcinoma. | Hepatocellular carcinoma (HCC) is one of the leading causes of death induced by cancer in the modern world and majority of the cases are related to chronic hepatitis B virus (HBV) infection. HBV-encoded X protein (HBx) is known to play a pivotal role in the pathogenesis of viral induced HCC. HBx is a multifunctional pr... | 25,132,741 | [
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0.04304859,
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0.1647843,
0.2303512,
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... |
Natural history of chronic hepatitis B: phases in a complex relationship. | Chronic hepatitis B (CHB) is a condition of global prevalence and its sequelae include cirrhosis and hepatocellular carcinoma. The natural history of CHB is a complex interplay of virological, environmental and host factors. The dynamic relationship between the virus and host evolves over the duration of the infection ... | 25,132,755 | [
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Proton pump inhibitor responsive esophageal eosinophilia, a distinct disease entity? | Recent studies have suggested the existence of a patient population with esophageal eosinophilia that responds to proton pump inhibitor therapy. These patients are being referred to as having proton pump inhibitor responsive esophageal eosinophilia (PPI-REE), which is currently classified as a distinct and separate dis... | 25,132,757 | [
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Clinical epidemiology of gastric cancer in Hehuang valley of China: a 10-year epidemiological study of gastric cancer. | To investigate the clinical epidemiological characteristics of gastric cancer in the Hehuang valley, China, to provide a reference for treatment and prevention of regional gastric cancer. Between February 2003 and February 2013, the records of 2419 patients with gastric cancer were included in this study. The patient's... | 25,132,766 | [
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Comparative analysis of ERCP, IDUS, EUS and CT in predicting malignant bile duct strictures. | To compare endoscopic retrograde cholangio-pancreatography (ERCP), intraductal ultrasound (IDUS), endosonography (EUS), endoscopic transpapillary forceps biopsies (ETP) and computed tomography (CT) with respect to diagnosing malignant bile duct strictures. A patient cohort with bile duct strictures of unknown etiology ... | 25,132,767 | [
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Separating Octadecyltrimethoxysilane Hydrolysis and Condensation at the Air/Water Interface through Addition of Methyl Stearate. | The hydrolysis and condensation of octadecyltrimethoxysilane (OTMS) at the air/water interface were monitored through molecular area changes at a constant surface pressure of 10 mN/m. The onset of condensation was delayed through the addition of methyl stearate (SME) acting as an inert filler molecule. In the absence o... | 25,132,807 | [
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On the Existence and Uniqueness of the Scientific Method. | The ultimate utility of science is widely agreed upon: the comprehension of reality. But there is much controversy about what scientific understanding actually means, and how we should proceed in order to gain new scientific understanding. Is there a method for acquiring new scientific knowledge? Is this method unique ... | 25,132,810 | [
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Quantification of a secondary task-specific tremor in a violinist after a temporal lobectomy. | Task-specific tremors (TSTs) occur mainly during certain tasks and may be highly disabling. In this case study, we report on a 66-year-old violinist who developed a TST of the right arm only while playing the violin 4 weeks after a temporal lobectomy, which had been performed as a result of his temporal lobe epilepsy. ... | 25,132,815 | [
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0.1842281,
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Inhibiting lung lining fluid glutathione metabolism with GGsTop as a novel treatment for asthma. | Asthma is characterized by airway inflammation. Inflammation is associated with oxidant stress. Airway epithelial cells are shielded from this stress by a thin layer of lung lining fluid (LLF) which contains an abundance of the antioxidant glutathione. LLF glutathione metabolism is regulated by γ-glutamyl transferase (... | 25,132,819 | [
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Contrasting group analysis of Brazilian students with dyslexia and good readers using the computerized reading and writing assessment battery "BALE". | The analysis of cognitive processes underpinning reading and writing skills may help to distinguish different reading ability profiles. The present study used a Brazilian reading and writing battery to compare performance of students with dyslexia with two individually matched control groups: one contrasting on reading... | 25,132,829 | [
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0.33181,
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0.5285557,
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... |
The incidence and risk factors for lower limb skin graft failure. | Lower limb skin grafts are thought to have higher failure rates than skin grafts in other sites of the body. Currently, there is a paucity of literature on specific factors associated with lower limb skin graft failure. We present a series of 70 lower limb skin grafts in 50 patients with outcomes at 6 weeks. One-third ... | 25,132,847 | [
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MTNR1B Genetic Variability Is Associated with Gestational Diabetes in Czech Women. | The gene MTNR1B encodes a receptor for melatonin. Melatonin receptors are expressed in human β-cells, which implies that genetic variants might affect glucose tolerance. Meta-analysis confirmed that the rs10830963 shows the most robust association. The aim of the study was to assess the rs10830963 in Czech GDM patients... | 25,132,852 | [
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-... |
Heat Stress Increases Long-term Human Migration in Rural Pakistan. | Human migration attributable to climate events has recently received significant attention from the academic and policy communities (1-2). Quantitative evidence on the relationship between individual, permanent migration and natural disasters is limited (3-9). A 21-year longitudinal survey conducted in rural Pakistan (... | 25,132,865 | [
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Comparison of prescribing and dispensing processes between veterinarians and pharmacists in New Zealand: Are there opportunities for cooperation? | Prescribing and dispensing of medicines are fundamental processes in providing healthcare for both human and animal patients. There has been recent discussion in the literature to advocate for increased co-operation between pharmacists and veterinarians, however there is little data available about veterinary prescribi... | 25,132,886 | [
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0.07152... |
Hyperlipidemia medication management in patients admitted for a myocardial infarction. | The purpose of this study is to determine the percentage of patients admitted for acute myocardial infarction currently prescribed a statin, with low-density lipoprotein (LDL) <100 mg/dL, and high-density lipoprotein (HDL) <50 mg/dL for men and <55 mg/dL for women and evaluate their medication management with ... | 25,132,887 | [
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... |
High-grade microscopic hematuria in adult men can predict urothelial malignancy. | Microscopic hematuria in men younger than 40 is a confusing issue to urologists, especially when these men have normal radiological findings. We report our experience in looking for urologic malignancy in this group of patients. We conducted a prospective study for men with vague urological symptoms. We included men un... | 25,132,893 | [
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0.02994102,
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... |
A surgical challenge: Idiopathic scrotal elephantiasis. | Scrotal elephantiasis is a condition rarely encountered in developed nations. It is endemic in tropical regions due to the presence of filariasis (Wucheria bancrofti). We report 2 cases of idiopathic scrotal elephantiasis in Canadian citizens with no history of travel to endemic filariasis regions, malignancy, surgery ... | 25,132,898 | [
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0.129717,
-0.3795286,... |
Entertainment Venue Visiting and Commercial Sex in China. | Entertainment venues in China play an important role in the sexually transmitted disease (STD)/HIV epidemic. Most previous studies have focused on sex workers working in entertainment venues, but little is known about their clients. This study investigated the perceptions and behavior of the patrons visiting entertainm... | 25,132,901 | [
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... |
Linking the Ohio Cancer Incidence Surveillance System with Medicare, Medicaid, and Clinical Data from Home Health Care and Long Term Care Assessment Instruments: Paving the Way for New Research Endeavors in Geriatric Oncology. | This study describes the Ohio Cancer-Aging Linked Database, which mirrors in structure the linked Surveillance, Epidemiology, and End-Results (SEER)-Medicare files, but also incorporates data from Medicaid enrollment and claims files, the home health care (HHC) Outcome Assessment Information Set (OASIS), and the long t... | 25,132,914 | [
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0.6069059,
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0.3363932,
0.1512023,
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0.25... |
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