title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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ENAM mutations with incomplete penetrance. | Amelogenesis imperfecta (AI) is a genetic disease affecting tooth enamel formation. AI can be an isolated entity or a phenotype of syndromes. To date, more than 10 genes have been associated with various forms of AI. We have identified 2 unrelated Turkish families with hypoplastic AI and performed mutational analysis. ... | 25,143,514 | [
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How much does Disease Activity Score in 28 joints ESR and CRP calculations underestimate disease activity compared with the Simplified Disease Activity Index? | Disease Activity Score in 28 joints calculated with C-reactive protein (DAS28-CRP) is used instead of erythrocyte sedimentation rate (DAS28-ESR) to assess rheumatoid arthritis disease activity; however, values for remission and low disease activity (LDA) for DAS28-CRP have not been validated. American College of Rheuma... | 25,143,522 | [
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Mechanism by which a LINE protein recognizes its 3' tail RNA. | LINEs mobilize their own copies via retrotransposition. LINEs can be divided into two types. One is a stringent type, which constitutes a majority of LINEs. The other is a relaxed type. To elucidate the molecular mechanism of retrotransposition, we used here two different zebrafish LINEs belonging to the stringent type... | 25,143,533 | [
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Retinoid acid-related orphan receptor γ, RORγ, participates in diurnal transcriptional regulation of lipid metabolic genes. | The hepatic circadian clock plays a pivotal role in regulating major aspects of energy homeostasis and lipid metabolism. In this study, we show that RORγ robustly regulates the rhythmic expression of several lipid metabolic genes, including the insulin-induced gene 2a, Insig2a, elongation of very long chain fatty acids... | 25,143,535 | [
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Differential modulation of descending signals from the reticulospinal system during reaching and locomotion. | We tested the hypothesis that the same spinal interneuronal pathways are activated by the reticulospinal system during locomotion and reaching. If such were the case, we expected that microstimulation within the pontomedullary reticular formation (PMRF) would evoke qualitatively similar responses in muscles active duri... | 25,143,539 | [
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The organization and dynamics of corticostriatal pathways link the medial orbitofrontal cortex to future behavioral responses. | Accurately making a decision in the face of incongruent options increases the efficiency of making similar congruency decisions in the future. Contextual factors like reward can modulate this adaptive process, suggesting that networks associated with monitoring previous success and failure outcomes might contribute to ... | 25,143,543 | [
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A new electronic diary tool for mapping and tracking spatial and temporal head pain patterns in migraine. | We present an electronic tool for collecting data on the patterns of migraine headache onset and progression. A digitized map consisting of 44 color-coded segments was defined based on previous reports of migraine pain and the distribution of nerves in the face, head and neck. The map was overlaid on a schematic map of... | 25,143,550 | [
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A clinical interview versus prospective headache diaries in the diagnosis of menstrual migraine without aura. | The objective of this article is to compare the diagnosis of menstrual migraine without aura (MM) from a clinical interview with prospective headache diaries in a population-based study. A total of 237 women with self-reported migraine in at least half of menstruations were interviewed by a neurologist about headache a... | 25,143,553 | [
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Molecular and clinical diagnosis of group A streptococcal pharyngitis in children. | Group A Streptococcus (GAS) pharyngitis is a very common condition causing significant morbidity in children. Accurate diagnosis followed by appropriate antimicrobial therapy is recommended to prevent postinfectious sequelae. Diagnosis of GAS pharyngitis by a rapid antigen detection test (RADT) or culture in the absenc... | 25,143,573 | [
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Dietary calcium, phosphorus, and phytase effects on bird performance, intestinal morphology, mineral digestibility, and bone ash during a natural necrotic enteritis episode. | The objective of this study was to evaluate the effects of dietary Ca, P, and phytase on performance, intestinal morphology, bone ash, and Ca and P digestibility during a necrotic enteritis (NE) outbreak. The 35-d trial was designed as a 2 × 2 × 2 factorial, which included 2 Ca levels (0.6 and 0.9%), 2 P levels (0.3 an... | 25,143,591 | [
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Intersubject variability of and genetic effects on the brain's functional connectivity during infancy. | Infancy is a period featuring a high level of intersubject variability but the brain basis for such variability and the potential genetic/environmental contributions remain largely unexplored. The assessment of the brain's functional connectivity during infancy by the resting state functional magnetic resonance imaging... | 25,143,609 | [
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Neonatal amygdala lesions lead to increased activity of brain CRF systems and hypothalamic-pituitary-adrenal axis of juvenile rhesus monkeys. | The current study examined the long-term effects of neonatal amygdala (Neo-A) lesions on brain corticotropin-releasing factor (CRF) systems and hypothalamic-pituitary-adrenal (HPA) axis function of male and female prepubertal rhesus monkeys. At 12-months-old, CSF levels of CRF were measured and HPA axis activity was ch... | 25,143,624 | [
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Platelet rich plasma versus laser therapy in lateral epicondylitis of elbow. | Platelet rich plasma (PRP) extract has shown to be a general stimulation for repair and currently used widely in various sports injury. A prospective observational study was done to assess the efficacy of autologous PRP injection in lateral epicondylitis of elbow, and compare the result with low level laser therapy. Th... | 25,143,643 | [
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Stable Estimation of a Covariance Matrix Guided by Nuclear Norm Penalties. | Estimation of a covariance matrix or its inverse plays a central role in many statistical methods. For these methods to work reliably, estimated matrices must not only be invertible but also well-conditioned. The current paper introduces a novel prior to ensure a well-conditioned maximum a posteriori (MAP) covariance e... | 25,143,662 | [
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Green nail syndrome treated with the application of tobramycin eye drop. | Green nail syndrome (chromonychia) is a nail disorder characterized by onycholysis and green-black discoloration of the nail bed. This condition is often associated with chronic paronychia. Pseudomonas aeruginosa is the most commonly identified organism in cultures from the affected area. Despite the various treatment ... | 25,143,684 | [
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Clinical utility and patient perspectives on the use of extended half-life rFIXFc in the management of hemophilia B. | Hemophilia B is an X-linked genetic disease caused by mutation of the gene for coagulation protein factor IX (FIX), with an incidence of approximately once every 30,000 male births in all populations and ethnic groups. When severe, the disease leads to spontaneous life threatening bleeding episodes. When untreated, mos... | 25,143,713 | [
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A retrospective analysis focusing on a group of patients with dual diagnosis treated by both mental health and substance use services. | To highlight which demographic, familial, premorbid, clinical, therapeutic, rehabilitative, and assistance factors were related to dual diagnosis, which, in psychiatry, means the co-occurrence of both mental disorder and substance use in the same patient. Our sample (N=145) was chosen from all outpatients with a dual d... | 25,143,738 | [
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Heart rate variability measured early in patients with evolving acute coronary syndrome and 1-year outcomes of rehospitalization and mortality. | This study sought to examine the prognostic value of heart rate variability (HRV) measurement initiated immediately after emergency department presentation for patients with acute coronary syndrome (ACS). Altered HRV has been associated with adverse outcomes in heart disease, but the value of HRV measured during the ea... | 25,143,740 | [
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Initial LDH level can predict the survival benefit from bevacizumab in the first-line setting in Chinese patients with metastatic colorectal cancer. | Markers to predict the efficacy of bevacizumab treatment have been not fully validated in most cancers, including metastatic colorectal cancer (mCRC). The aim of this study was to investigate the potential role of lactate dehydrogenase (LDH) in predicting the survival benefit from first-line bevacizumab treatment, in C... | 25,143,746 | [
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Dietary pattern and asthma: a systematic review and meta-analysis. | The literature on the relationship between diet and asthma has largely focused on individual nutrients, with conflicting results. People consume a combination of foods from various groups that form a dietary pattern. Studying the role of dietary patterns in asthma is an emerging area of research. The purpose of this st... | 25,143,747 | [
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A randomized, double-blind, placebo-controlled clinical trial evaluating Dermytol(®) cream for the treatment of actinic keratoses. | Actinic keratosis lesions (AKs) have the potential to develop into squamous cell carcinoma (SCC) and thus therapies to prevent SCC development from AKs are warranted. The aim of this study was to assess the effects of a 3 month application of a canola phenolic acid-based cream (CPA) on AK lesions. This was a randomized... | 25,143,750 | [
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Role of uterine forces in intrauterine device embedment, perforation, and expulsion. | The purpose of this study was to examine factors that could help reduce primary perforation during insertion of a framed intrauterine device (IUD) and to determine factors that contribute in generating enough uterine muscle force to cause embedment and secondary perforation of an IUD. The objective was also to evaluate... | 25,143,756 | [
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A mixed methods study of student perceptions of using standardized patients for learning and evaluation. | Educators recognize the value of using standardized patients (SPs) when teaching and evaluating clinical skills in rehabilitation entry-to-practice education programs but have published little supporting evidence and have yet to evaluate programmatic SP use from a student perspective. This study explored occupational a... | 25,143,758 | [
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Prophylactic Appendectomy during Laparoscopic Surgery for Other Conditions. | Acute appendicitis remains the most common surgical emergency. Laparoscopy has gained increasing favor as a method of both investigating right iliac fossa pain and treating the finding of appendicitis. A question arises: what to do with an apparent healthy appendix discovered during laparoscopic surgery for other patho... | 25,143,764 | [
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Melatonin's Effect in Febrile Seizures and Epilepsy. | Recognition of risk factors for febrile seizures (FS) and epilepsy is essential. Studies regarding the role of melatonin in these convulsive disorders are limited. This study determines the relationship between serum melatonin levels and FS and epilepsy in children. A population of 111 children with simple FS, complex ... | 25,143,770 | [
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Is "benign Childhood Epilepsy with Centrotemporal Spikes" Always Benign? | To determine the prevalence of associated behavioral problems and prognosis with Benign Childhood Epilepsy with CentroTemporal Spikes (BCECTS). Descriptive, Cross Sectional study that was conducted from October 2009 to April 2013 in the Department of Pediatric Neurology, the Children's Hospital Taif, KSA. This study wa... | 25,143,772 | [
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Paroxysmal nocturnal hemoglobinuria presenting as cerebral venous sinus thrombosis: a case report. | Paroxysmal Nocturnal Hemoglobinuria (PNH) is a rare type of acquired hemolytic anemia that is frequently associated with thrombophilia. It may rarely present with cerebral venous sinus thrombosis, which manifests clinically with signs of raised intracranial pressure and requires lifelong anticoagulation therapy. One su... | 25,143,784 | [
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Pachymic Acid Enhances Pentobarbital-Induced Sleeping Behaviors via GABAA-ergic Systems in Mice. | This study was investigated to know whether pachymic acid (PA), one of the predominant triterpenoids in Poria cocos (Hoelen) has the sedative-hypnotic effects, and underlying mechanisms are mediated via γ-aminobutyric acid (GABA)-ergic systems. Oral administration of PA markedly suppressed locomotion activity in mice. ... | 25,143,810 | [
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Routes and mechanisms of extracellular vesicle uptake. | Extracellular vesicles (EVs) are small vesicles released by donor cells that can be taken up by recipient cells. Despite their discovery decades ago, it has only recently become apparent that EVs play an important role in cell-to-cell communication. EVs can carry a range of nucleic acids and proteins which can have a s... | 25,143,819 | [
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The nasal cavity microbiota of healthy adults. | The microbiota of the nares has been widely studied. However, relatively few studies have investigated the microbiota of the nasal cavity posterior to the nares. This distinct environment has the potential to contain a distinct microbiota and play an important role in health. We obtained 35,142 high-quality bacterial 1... | 25,143,824 | [
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Case report: a 37-year-old male with telangiectasias, polycythemia vera, perinephric fluid collections, and intrapulmonary shunting. | The TEMPI syndrome was recently described in 2011, and is characterized by the constellation of five hallmarks: Telangiectasias, Erythrocytosis and elevated Erythropoietin, Monoclonal gammopathy, Perinephric fluids collections, and Intrapulmonary shunting. The underlying pathophysiology is unknown, though it has been p... | 25,143,825 | [
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Evaluation of pachymetric measurements with scheimpflug photography-based system and optical coherence tomography pachymetry at different stages of keratoconus. | The aim of this study was to compare the central and peripheral pachymetric measurements determined with Sirius system and Visante OCT and evaluate the agreement between them at different stages of keratoconus. Measurements were not significantly different in all patients and subgroups and showed high correlation for t... | 25,143,828 | [
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Minimally invasive esophagectomy for esophageal cancer: the first experience from Pakistan. | Two common procedures for esophageal resection are Ivor Lewis esophagectomy and transhiatal esophagectomy. Both procedures have high morbidity rates of 20-46%. Minimally invasive esophagectomy has been introduced to decrease morbidity. We report initial experience of MIE to determine the morbidity and mortality associa... | 25,143,832 | [
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Aggressive Subcutaneous Panniculitis-Like CD30+ Peripheral T-Cell Lymphoma with Diffuse EBER Expression. | T-cell lineage lymphoma with an intense membranous and paranuclear CD30 expression in the absence of ALK1 raises a differential diagnosis of peripheral T-cell lymphoma (PTCL), NOS and anaplastic large cell lymphoma (ALCL), ALK negative. However, Epstein-Barr virus is consistently negative in ALCL and is not considered ... | 25,143,841 | [
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Isolated asymptomatic short sternum in a healthy young girl. | Congenital sternal defects are rare deformities frequently associated with other anomalies of the chest wall and other organ systems. Although pectus excavatum, pectus carinatum, and cleft sternum can present as isolated deformity, in most cases they are associated with heart and inner organs anomalies and described as... | 25,143,854 | [
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Initial in vivo PET imaging of 5-HT1A receptors with 3-[(18)F]mefway. | 4-trans-[(18)F]Mefway is a PET radiotracer with high affinity for 5-HT1A receptors. Our preliminary work indicated the positional isomer, 3-[(18)F]mefway, would be suitable for PET imaging of 5-HT1A receptors. We now compare the in vivo behaviour of 3-mefway with 4-mefway to evaluate 3-[(18)F]mefway as a potential 5-HT... | 25,143,866 | [
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Molecular analysis of interleukin-25 exons 1 and 2 and its serum levels in Iranian patients with multiple sclerosis. | Overexpression of Interleukin-17 (IL-17) family has been shown in a variety of autoimmune diseases. IL-25 (IL-17E), as a member of this family of cytokines, induces the overexpression of IL-13 and impedes Th17/IL-17 responses. In the present study potential single nucleotide polymorphisms (SNP) of IL-25, its serum leve... | 25,143,869 | [
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Modified case based learning: Our experience with a new module for pharmacology undergraduate teaching. | The undergraduate teaching in pharmacology has always been a challenging task for medical teachers. Traditional lecture format is monotonous and a passive way of learning. There is a need to shift the educational focus from content centered to case based. In an effort to create interest and further improve the student ... | 25,143,883 | [
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Diabetes mellitus and suicide. | Relationship of diabetes mellitus (DM) with metal health disorders such as depression has been explored extensively in the published literatures. However, association of diabetes mellitus with suicidal tendencies has been evaluated less extensively. The present narrative review aimed to assess the literature relating t... | 25,143,900 | [
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RET mutations in a large indian family with medullary thyroid carcinoma. | Medullary thyroid carcinoma (MTC) is a tumor arising from the para follicular (C) cells of the thyroid gland and can occur either sporadically or as part of an inherited syndrome. A proportion of these cases carry an autosomal dominant mutation in the RET (REarranged during Transfection) proto-oncogene. Screening for t... | 25,143,909 | [
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Does pulsed magnetic field therapy influence nerve regeneration in the median nerve model of the rat? | The aim of this study was to evaluate the impact of pulsed magnetic field therapy on peripheral nerve regeneration after median nerve injury and primary coaptation in the rat. Both median nerves were surgically exposed and denervated in 24 female Wistar rats. A microsurgical coaptation was performed on the right side, ... | 25,143,937 | [
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Test anxiety levels of board exam going students in Tamil Nadu, India. | The latest report by the National Crime Records Bureau has positioned Tamil Nadu as the Indian state with highest suicide rate. At least in part, this is happening due to exam pressure among adolescents, emphasizing the imperative need to understand the pattern of anxiety and various factors contributing to it among st... | 25,143,938 | [
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The role of oxidative stress and inflammation in cardiovascular aging. | Age is an independent risk factor of cardiovascular disease, even in the absence of other traditional factors. Emerging evidence in experimental animal and human models has emphasized a central role for two main mechanisms of age-related cardiovascular disease: oxidative stress and inflammation. Excess reactive oxygen ... | 25,143,940 | [
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Identifying hierarchical and overlapping protein complexes based on essential protein-protein interactions and "seed-expanding" method. | Many evidences have demonstrated that protein complexes are overlapping and hierarchically organized in PPI networks. Meanwhile, the large size of PPI network wants complex detection methods have low time complexity. Up to now, few methods can identify overlapping and hierarchical protein complexes in a PPI network qui... | 25,143,945 | [
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The genetic structure of wild Orobanche cumana Wallr. (Orobanchaceae) populations in eastern Bulgaria reflects introgressions from weedy populations. | Orobanche cumana is a holoparasitic plant naturally distributed from central Asia to south-eastern Europe, where it parasitizes wild Asteraceae species. It is also an important parasitic weed of sunflower crops. The objective of this research was to investigate genetic diversity, population structure, and virulence on ... | 25,143,963 | [
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RSSI-based smooth localization for indoor environment. | Radio frequency (RF) technique, for its better penetrability over traditional techniques such as infrared or ultrasound, is widely used for indoor localization and tracking. In this paper, three novel measurements, point decision accuracy, path matching error and wrong jumping ratio, are firstly defined to express the ... | 25,143,988 | [
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Gorgonian disease outbreak in the Gulf of Naples: pathology reveals cyanobacterial infection linked to elevated sea temperatures. | In recent years, mass mortality events of benthic invertebrates in the Mediterranean Sea have been documented to coincide with the increased seawater temperatures associated with global climate change. Following a disease outbreak in gorgonians during the summer seasons of 2008 and 2009 in the Gulf of Naples (Tyrrhenia... | 25,144,119 | [
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Total fructose intake and risk of hypertension: a systematic review and meta-analysis of prospective cohorts. | Although most controlled feeding trials have failed to show an adverse effect of fructose on blood pressure, concerns continue to be raised regarding the role of fructose in hypertension. To quantify the association between fructose-containing sugar (high-fructose corn syrup, sucrose, and fructose) intake and incident ... | 25,144,126 | [
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Using testosterone and cortisol as biomarker for training individualization in elite basketball: a 4-year follow-up study. | The purpose of this study was to determine the responses of testosterone and cortisol, with special reference to playing positions, playing time (PT), and phase of the season. We performed a follow-up study during 4 consecutive seasons to investigate the effects of PT, positional role, and phase of the season on anabol... | 25,144,130 | [
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Higher levels of sex chromosome heteromorphism are associated with markedly stronger reproductive isolation. | The two 'rules of speciation', Haldane's rule and the large X-effect, describe the genetic basis of postzygotic isolation, and have led to the realization that sex chromosomes play an important role in this process. However, a range of sex determination mechanisms exists in nature, not always involving sex chromosomes.... | 25,144,162 | [
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Reviewing effectiveness of ankle assessment techniques for use in robot-assisted therapy. | This article provides a comprehensive review of studies that investigated ankle assessment techniques to better understand those that can be used in the real-time monitoring of rehabilitation progress for implementation in conjunction with robot-assisted therapy. Seventy-six publications published between January 1980 ... | 25,144,166 | [
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Development of a progressive audiologic tinnitus management program for Veterans with tinnitus. | Tinnitus is the most prevalent service-connected disability awarded to Veterans. However, clinical protocols for management of tinnitus have been inconsistent across Department of Veterans Affairs (VA) medical centers. A study was funded to develop and pilot test a protocol to provide tinnitus services consistently acr... | 25,144,174 | [
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Test-retest reliability and rater agreements of assessment of capacity for myoelectric control version 2.0. | The Assessment of Capacity for Myoelectric Control (ACMC) is an observation-based tool that evaluates ability to control a myoelectric prosthetic hand. Validity evidence led to ACMC version 2.0, but the test-retest reliability and minimal detectable change (MDC) of the ACMC have never been evaluated. Investigation of r... | 25,144,176 | [
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External validation of the simple clinical score and the HOTEL score, two scores for predicting short-term mortality after admission to an acute medical unit. | Clinical scores can be of aid to predict early mortality after admission to a medical admission unit. A developed scoring system needs to be externally validated to minimise the risk of the discriminatory power and calibration to be falsely elevated. We performed the present study with the objective of validating the S... | 25,144,186 | [
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Differential sensitivity of Src-family kinases to activation by SH3 domain displacement. | Src-family kinases (SFKs) are non-receptor protein-tyrosine kinases involved in a variety of signaling pathways in virtually every cell type. The SFKs share a common negative regulatory mechanism that involves intramolecular interactions of the SH3 domain with the PPII helix formed by the SH2-kinase linker as well as t... | 25,144,189 | [
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Psychological stress exerts effects on pathogenesis of hepatitis B via type-1/type-2 cytokines shift toward type-2 cytokine response. | Psychological and physical stress has been demonstrated to have an impact on health through modulation of immune function. Despite high prevalence of stress among patients with hepatitis B virus (HBV) infection, little is known about whether and how stress exerts an effect on the course of hepatitis B. Eighty patients ... | 25,144,199 | [
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The role of emotion in musical improvisation: an analysis of structural features. | One of the primary functions of music is to convey emotion, yet how music accomplishes this task remains unclear. For example, simple correlations between mode (major vs. minor) and emotion (happy vs. sad) do not adequately explain the enormous range, subtlety or complexity of musically induced emotions. In this study,... | 25,144,200 | [
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Patterns of shoulder imbalance in adolescent idiopathic scoliosis: a retrospective observational study. | Retrospective cohort study. To study the relationship between the proximal spine and shoulder levels in adolescent idiopathic scoliosis (AIS). It has been frequently observed that the shoulder levels do not correspond to the spinal curve direction in AIS. Eighty-five operated cases of AIS were analyzed retrospectively ... | 25,144,206 | [
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Myocardial and microvascular inflammation/infection in patients with HIV-associated pulmonary artery hypertension. | Right ventricle compromise affects survival of patients with HIV-associated pulmonary artery hypertension (PAH). Myocardial histology with viral assessment may clarify the mechanism of right ventricular deterioration and provide clues on PAH origin. Fifteen patients with HIV infection, PAH and right ventricular dysfunc... | 25,144,217 | [
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Detection of MPLW515L/K mutations and determination of allele frequencies with a single-tube PCR assay. | A gain-of-function mutation in the myeloproliferative leukemia virus (MPL) gene, which encodes the thrombopoietin receptor, has been identified in patients with essential thrombocythemia and primary myelofibrosis, subgroups of classic myeloproliferative neoplasms (MPNs). The presence of MPL gene mutations is a critical... | 25,144,224 | [
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Distinct kinetics in the frequency of peripheral CD4+ T cells in patients with ulcerative colitis experiencing a flare during treatment with mesalazine or with a herbal preparation of myrrh, chamomile, and coffee charcoal. | We found the first evidence of the efficacy of a herbal treatment with myrrh, dry extract of chamomile flowers, and coffee charcoal for ulcerative colitis (UC). However, the impact of the herbal treatment on the CD4+ T-cell compartment, which is essential for both the induction of UC and the maintenance of tolerance in... | 25,144,293 | [
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Rapidly self-renewing human multipotent marrow stromal cells (hMSC) express sialyl Lewis X and actively adhere to arterial endothelium in a chick embryo model system. | There have been conflicting observations regarding the receptors utilized by human multipotent mesenchymal bone marrow stromal cells (hMSC) to adhere to endothelial cells (EC). To address the discrepancies, we performed experiments with cells prepared with a standardized, low-density protocol preserving a sub-populatio... | 25,144,321 | [
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Positron emission tomography in CNS drug discovery and drug monitoring. | Molecular imaging methods such as positron emission tomography (PET) are increasingly involved in the development of new drugs. Using radioactive tracers as imaging probes, PET allows the determination of the pharmacokinetic and pharmacodynamic properties of a drug candidate, via recording target engagement, the patter... | 25,144,329 | [
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Simulation-based education and performance assessments for pediatric surgeons. | Education in the knowledge, skills, and attitudes necessary for a surgeon to perform at an expert level in the operating room, and beyond, must address all potential cognitive and technical performance gaps, professionalism and personal behaviors, and effective team communication. Educational strategies should also see... | 25,144,355 | [
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Pronator teres opposition transfer through Guyon's canal: a technique. | Restoration of thumb opposition in the setting of peripheral nerve or brachial plexus injury is critical to upper limb function. When commonly utilized opposition donors are unavailable for clinical use, the pronator teres represents a good and reliable tendon for restoration of thumb opposition. Here we describe our r... | 25,144,357 | [
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Tracing the evolution of lineage-specific transcription factor binding sites in a birth-death framework. | Changes in cis-regulatory element composition that result in novel patterns of gene expression are thought to be a major contributor to the evolution of lineage-specific traits. Although transcription factor binding events show substantial variation across species, most computational approaches to study regulatory elem... | 25,144,359 | [
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Chemokine-like factor 1 promotes the migration of rat primary cortical neurons by the induction of actin polymerization. | Chemokine-like factor 1 (CKLF1), a newly cloned chemotactic cytokine, plays an essential role in immune cell migration. However, the potential role of CKLF1 in the cortical neuronal migration remains unclear. In the present research, by measuring the distance between the margin of brain slices and the leading populatio... | 25,144,394 | [
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Resource-poor settings: response, recovery, and research: care of the critically ill and injured during pandemics and disasters: CHEST consensus statement. | Planning for mass critical care in resource-poor and constrained settings has been largely ignored, despite large, densely crowded populations who are prone to suffer disproportionately from natural disasters. As a result, disaster response has been suboptimal and in many instances hampered by lack of planning, educati... | 25,144,410 | [
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The invisible issue of organ laundering. | Global institutions, although suggesting measures to deter organ trafficking, reiterate the lack of official statistics about this illegal trade. In this article, we explore the reasons why organ trafficking remains unreported. We argue that the complex factors that perpetuate invisibility facilitate trafficked organs ... | 25,144,445 | [
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van der Waals radii of noble gases. | Consistent van der Waals radii are deduced for Ne-Xe, based on the noble gas···oxygen intermolecular distances found in gas phase structures. The set of radii proposed is shown to provide van der Waals distances for a wide variety of noble gas···element atom pairs that represent properly the distribution of distances b... | 25,144,450 | [
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Microcirculatory changes identified by photoacoustic microscopy in patients with complex regional pain syndrome type I after stellate ganglion blocks. | Complex regional pain syndrome (CRPS) is a chronic pain syndrome that causes intractable pain, disability, and poor quality of life for patients. The etiology and pathophysiology of CRPS are still poorly understood. Due to a lack of proper diagnostic tools, the prognosis of CRPS is primarily based on clinical observati... | 25,144,451 | [
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LIN-3/EGF promotes the programmed cell death of specific cells in Caenorhabditis elegans by transcriptional activation of the pro-apoptotic gene egl-1. | Programmed cell death (PCD) is the physiological death of a cell mediated by an intracellular suicide program. Although key components of the PCD execution pathway have been identified, how PCD is regulated during development is poorly understood. Here, we report that the epidermal growth factor (EGF)-like ligand LIN-3... | 25,144,461 | [
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Magnon transistor for all-magnon data processing. | An attractive direction in next-generation information processing is the development of systems employing particles or quasiparticles other than electrons--ideally with low dissipation--as information carriers. One such candidate is the magnon: the quasiparticle associated with the eigen-excitations of magnetic materia... | 25,144,479 | [
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Redefining "charge nurse" within the front line. | Don't overlook the importance of charge nurses. Learn how one organization redefined the role and strengthened these leaders, increasing patient and staff satisfaction. | 25,144,488 | [
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Hydrotropy: monomer-micelle equilibrium and minimum hydrotrope concentration. | Drug molecules with low aqueous solubility can be solubilized by a class of cosolvents, known as hydrotropes. Their action has often been explained by an analogy with micelle formation, which exhibits critical micelle concentration (CMC). Indeed, hydrotropes also exhibit "minimum hydrotrope concentration" (MHC), a thre... | 25,144,510 | [
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Plasma exchange in antineutrophil cytoplasm antibody-associated vasculitis. | This article reviews the use of plasma exchange for the treatment of antineutrophil cytoplasm antibody-associated vasculitis (AAV) with a focus on current controversies and knowledge gaps. Experimental evidence suggesting that antineutrophil cytoplasm antibodies are pathogenic continues to evolve and support the theory... | 25,144,513 | [
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New Kagome metal Sc₃Mn₃Al₇Si₅ and its gallium-doped analogues: synthesis, crystal structure, and physical properties. | We report the synthesis, crystal structure, and basic properties of the new intermetallic compound Sc3Mn3Al7Si5. The structure of the compound was established by single-crystal X-ray diffraction, and it crystallizes with a hexagonal structure (Sc3Ni11Si4 type) with Mn atoms forming the Kagome nets. The dc magnetic susc... | 25,144,523 | [
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Personal trust increases cooperation beyond general trust. | In this paper we present a new methodology which, while allowing for anonymous interaction, it also makes possible to compare decisions of cooperating or defecting when playing games within a group, according to whether or not players personally trust each other. The design thus goes beyond standard approaches to the r... | 25,144,539 | [
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Synthesis of 1-(2,3-dihydrobenzofuran-3-yl)-methanesulfonohydrazides through insertion of sulfur dioxide. | A three-component reaction of 2-(allyloxy)anilines, sulfur dioxide and hydrazines under mild conditions is developed, which gives rise to 1-(2,3-dihydrobenzofuran-3-yl)-methanesulfonohydrazides in good yields. This radical process involves an intramolecular 5-exo-cyclization and insertion of sulfur dioxide. | 25,144,558 | [
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Functional specialization among members of Knickkopf family of proteins in insect cuticle organization. | Our recent study on the functional analysis of the Knickkopf protein from T. castaneum (TcKnk), indicated a novel role for this protein in protection of chitin from degradation by chitinases. Knk is also required for the laminar organization of chitin in the procuticle. During a bioinformatics search using this protein... | 25,144,557 | [
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UK audit of glomerular filtration rate measurement from plasma sampling in 2013. | An audit was carried out into UK glomerular filtration rate (GFR) calculation. The results were compared with an identical 2001 audit. Participants used their routine method to calculate GFR for 20 data sets (four plasma samples) in millilitres per minute and also the GFR normalized for body surface area. Some unsound ... | 25,144,565 | [
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"The uncertainty is what is driving me crazy": the tripartite model of uncertainty in the adolescent and young adult cancer context. | Building on scholarship indicating that uncertainty is a fundamental component of the cancer experience, this study focuses on an understudied population: adolescents and young adults (AYAs) with cancer. Because AYAs' health outcomes lag behind those of older and younger people with cancer, scholars have recommended th... | 25,144,578 | [
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Longitudinal relationships among visual acuity, daily functional status, and mortality: the Salisbury Eye Evaluation Study. | Determination of the mechanisms by which visual loss increases mortality risk is important for developing interventional strategies. To evaluate the direct and indirect effects of loss of visual acuity (VA) on mortality risk through functional status changes among aging adults. Prospective longitudinal study of a popul... | 25,144,579 | [
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0.00220499,
0.05284502,
0.04179848,
-0.2044756,
0.4186157,
-0.04661185,
... |
Women's center staff perceptions of the campus climate on sexual violence. | Sexual assault is a major public health problem disproportionately affecting women on college and university campuses. As sexual assault is often unreported, survivors may not have the access to resources and services that are helpful in healing. Campus-based women's centers provide a comfortable place and resource to ... | 25,144,584 | [
-0.1161962,
0.1931063,
0.03295239,
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0.1042766,
0.01798185,
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... |
Victimization and perpetration of sexual violence in college-aged men and women. | Sexual violence is a significant public health issue on college campuses. Much of the research to date has focused on sexual violence victimization with less data on perpetration of sexual violence. This analysis describes sexual violence victimization and perpetration experiences in a sample of college students. We so... | 25,144,586 | [
-0.2673928,
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0.1504678,
0.2592004,
-0.5131955,
0.2639977,
0.1726539,
-0.04794319,
0.0876... |
Tuning electronic and magnetic properties of silicene with magnetic superhalogens. | Due to its compatibility with the well-developed Si-based semiconductor industry, silicene has attracted considerable attention. Using density functional theory we show for the first time that the recently synthesized superhalogen MnCl3 can be used to tune the electronic and magnetic properties of silicene, from semi-m... | 25,144,623 | [
-0.1607969,
0.1952549,
0.1339688,
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0.0917713,
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0.1590641,
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0.002896167,
-0.1131... |
Remission after potassium iodide therapy in patients with Graves' hyperthyroidism exhibiting thionamide-associated side effects. | Thionamides have various side effects. The effectiveness of potassium iodide (KI) was evaluated in hyperthyroid patients who experienced side effects to thionamides. An observational study was conducted at an academic medical center. Among 1388 patients with Graves' hyperthyroidism treated with thionamides, 204 (14.7%)... | 25,144,628 | [
-0.1122951,
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0.192647,
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0.2667364,
-0.189996... |
A simple algorithm for treating horizontal benign paroxysmal positional vertigo. | Horizontal benign paroxysmal positional vertigo (H-BPPV) is more difficult to successfully treat than posterior benign paroxysmal positional vertigo (P-BPPV) because of the diverse mechanisms required. We developed a simple, rapid, and effective treatment algorithm for treating all subtypes of H-BPPV in an ear, nose, a... | 25,144,642 | [
-0.165151,
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0.09294858,
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0.0155571... |
Relationship between bone mineral density and a 10-year risk for coronary artery disease in a healthy Korean population: the Korea National Health and Nutrition Examination Survey 2008-2010. | Bone mineral density (BMD) is associated with atherosclerosis and vascular calcification. If BMD is related independently to the risk of coronary heart disease (CHD), BMD could play an important role in CHD risk prediction. We assessed the hypothesis that BMD is related independently to the risk of CHD. We used data fr... | 25,144,671 | [
-0.3234767,
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0.06311368,
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0.239243,
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0.02002202,
0.1843954,
-0.03480266,
... |
Feature selection for the identification of antitumor compounds in the alcohol total extracts of Curcuma longa. | Antitumor activity has been reported for turmeric, the dried rhizome of Curcuma longa. This study proposes a new feature selection method for the identification of the antitumor compounds in turmeric total extracts. The chemical composition of turmeric total extracts was analyzed by gas chromatography-mass spectrometry... | 25,144,675 | [
-0.07860736,
0.3172964,
0.01443593,
0.2514084,
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0.5802327,
0.2422483,
0.1292866,
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0.1565686,
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0... |
Factors associated with perceived health among Korean adolescents. | This study examined the influences of personal, social, and environmental-structural factors on the perceived health of Korean adolescents. Using a two-stage generalized hierarchical logistic linear multilevel model, this study found that general high school enrollment, younger age, normal weight, and frequent exercise... | 25,144,695 | [
-0.1114917,
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0.2587481,
0.01929855,
-0.2476233,
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0.2905746,
-0.192068... |
A model-based approach for identifying signatures of ancient balancing selection in genetic data. | While much effort has focused on detecting positive and negative directional selection in the human genome, relatively little work has been devoted to balancing selection. This lack of attention is likely due to the paucity of sophisticated methods for identifying sites under balancing selection. Here we develop two co... | 25,144,706 | [
-0.03971795,
0.003695152,
-0.2101489,
-0.08738843,
0.3428476,
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0.3392541,
0.2901277,
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0.05568492,
0.1203915,
0.2358036,
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0.05386708,
0.1067679,
0.03200684,
0.2708105,
-0.1537897,... |
The Par-PrkC polarity complex is required for cilia growth in zebrafish photoreceptors. | Specification and development of the apical membrane in epithelial cells requires the function of polarity proteins, including Pard3 and an atypical protein kinase C (PrkC). Many epithelial cells possess microtubule-based organelles, known as cilia, that project from their apical surface and the membrane surrounding th... | 25,144,710 | [
0.1307203,
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0.288107,
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0.2277356,
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... |
System-level planning, coordination, and communication: care of the critically ill and injured during pandemics and disasters: CHEST consensus statement. | System-level planning involves uniting hospitals and health systems, local/regional government agencies, emergency medical services, and other health-care entities involved in coordinating and enabling care in a major disaster. We reviewed the literature and sought expert opinions concerning system-level planning and e... | 25,144,713 | [
-0.324624,
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0.05083682,
0.123393,
-0.1892826,
-0.1371762,
-0.1381531,
0.00031423... |
Mir-509-5p joins the Mdm2/p53 feedback loop and regulates cancer cell growth. | Although the Mdm2/p53 interaction has been well documented, it is not clear whether there are new microRNAs participating in this regulatory network. Here, we provide evidence that miR-509-5p, which is downregulated in a subset of newly diagnosed cervical cancer and hepatocellular carcinoma tissues compared with the ad... | 25,144,722 | [
-0.2719957,
0.1464842,
0.001672614,
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0.189658,
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0.2931391,
0.2862859,
0.008915768,
0.... |
Circulating mucosal associated invariant T cells are activated in Vibrio cholerae O1 infection and associated with lipopolysaccharide antibody responses. | Mucosal Associated Invariant T (MAIT) cells are innate-like T cells found in abundance in the intestinal mucosa, and are thought to play a role in bridging the innate-adaptive interface. We measured MAIT cell frequencies and antibody responses in blood from patients presenting with culture-confirmed severe cholera to a... | 25,144,724 | [
-0.02133461,
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-0.07782966,
-0.07257989,
0.1732981,
0.2058283,
-0.01967345... |
Rational design of a fusion protein to exhibit disulfide-mediated logic gate behavior. | Synthetic cellular logic gates are primarily built from gene circuits owing to their inherent modularity. Single proteins can also possess logic gate functions and offer the potential to be simpler, quicker, and less dependent on cellular resources than gene circuits. However, the design of protein logic gates that are... | 25,144,732 | [
0.1153731,
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0.23105,
0.1735784,
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0.05... |
Structural and biochemical characterization of the Cop9 signalosome CSN5/CSN6 heterodimer. | The Cop9 signalosome complex (CSN) regulates the functional cycle of the major E3 ubiquitin ligase family, the cullin RING E3 ubiquitin ligases (CRLs). Activated CRLs are covalently modified by the ubiquitin-like protein Nedd8 (neural precursor cell expressed developmentally down-regulated protein 8). CSN serves an ess... | 25,144,743 | [
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0.01184221,
0.1209686,
0.1803267,... |
Immunization with Hexon modified adenoviral vectors integrated with gp83 epitope provides protection against Trypanosoma cruzi infection. | Trypanosoma cruzi is the causative agent of Chagas disease. Chagas disease is an endemic infection that affects over 8 million people throughout Latin America and now has become a global challenge. The current pharmacological treatment of patients is unsuccessful in most cases, highly toxic, and no vaccines are availab... | 25,144,771 | [
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0.1301876,
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0.4013891,
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The MAP kinase p38 is part of Drosophila melanogaster's circadian clock. | All organisms have to adapt to acute as well as to regularly occurring changes in the environment. To deal with these major challenges organisms evolved two fundamental mechanisms: the p38 mitogen-activated protein kinase (MAPK) pathway, a major stress pathway for signaling stressful events, and circadian clocks to pre... | 25,144,774 | [
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0.1374059,
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0.1476252,
0.1861166,
0.009283439,... |
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