title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
|---|---|---|---|
Modeling companion diagnostics in economic evaluations of targeted oncology therapies: systematic review and methodological checklist. | The successful use of a targeted therapy is intrinsically linked to the ability of a companion diagnostic to correctly identify patients most likely to benefit from treatment. The aim of this study was to review the characteristics of companion diagnostics that are of importance for inclusion in an economic evaluation.... | 25,142,227 | [
-0.06200324,
0.09997495,
-0.04387657,
-0.3664812,
0.008187071,
-0.1279574,
0.02916006,
0.1720399,
0.32606,
-0.02713419,
-0.09548227,
0.1822135,
0.1048367,
-0.1561824,
-0.172032,
0.03865827,
-0.3972587,
0.07354331,
-0.06352514,
0.1363288,
0.13771,
0.1057737,
-0.1052304,
... |
Immunization with a novel chimeric peptide representing B and T cell epitopes from HER2 extracellular domain (HER2 ECD) for breast cancer. | Because of direct stimulating immune system against disease, vaccination or active immunotherapy is preferable compared to passive immunotherapy. For this purpose, a newly designed chimeric peptide containing epitopes for both B and T cells from HER2 ECD subdomain III was proposed. To evaluate the effects of the active... | 25,142,233 | [
0.007496058,
-0.3991554,
-0.05538836,
-0.01252954,
0.009347019,
-0.08557432,
0.04456139,
0.4450471,
-0.04302648,
0.1737829,
-0.1901638,
0.4307424,
0.06563419,
0.341558,
-0.2735942,
-0.1232596,
-0.4222812,
0.1250451,
-0.2060486,
0.1246874,
0.3929248,
0.01219065,
-0.0717221... |
Tacrolimus pharmacodynamics and pharmacogenetics along the calcineurin pathway in human lymphocytes. | Although therapeutic drug monitoring has improved the clinical use of immunosuppressive drugs, there is still interpatient variability in efficacy and toxicity that pharmacodynamic monitoring may help to reduce. To select the best biomarkers of tacrolimus pharmacodynamics, we explored the strength and variability of si... | 25,142,246 | [
-0.07272296,
-0.1972215,
-0.2554529,
-0.1939289,
0.1147167,
-0.1891181,
-0.2094663,
0.1959052,
0.0593168,
-0.1172022,
0.08361938,
-0.533844,
0.01021198,
-0.07403202,
-0.3988131,
-0.1187738,
-0.4842945,
-0.2398479,
-0.05065969,
0.4385019,
0.3841958,
0.4648403,
0.1202798,
... |
College Students: Mental Health Problems and Treatment Considerations. | Attending college can be a stressful time for many students. In addition to coping with academic pressure, some students have to deal with the stressful tasks of separation and individuation from their family of origin while some may have to attend to numerous work and family responsibilities. In this context, many col... | 25,142,250 | [
-0.2085339,
0.2618532,
0.04693804,
0.03358497,
0.006413808,
-0.1903816,
-0.2432349,
-0.06971503,
-0.08051773,
0.1324498,
0.141597,
-0.2871762,
-0.235377,
-0.01378213,
-0.3554228,
-0.01555097,
0.1195639,
0.2918305,
-0.0685158,
-0.1410816,
0.0145586,
0.2629934,
-0.1714316,
... |
Distal femoral osteotomy. | Osteotomies around the knee are well-recognized treatments for unloading the affected compartment in cases of lower limb malalignment. There are few papers in the literature describing the outcomes of distal femoral osteotomy (DFO), as compared with the studies reporting on high tibial osteotomy (HTO), probably because... | 25,142,271 | [
-0.01585233,
0.06984363,
0.2529275,
-0.2518048,
-0.09910028,
-0.1557494,
-0.01007956,
0.2363475,
-0.4394253,
0.06072646,
0.255518,
-0.2385621,
-0.1132907,
-0.114341,
-0.2529247,
-0.5235671,
-0.07697351,
0.5244608,
-0.2787141,
-0.2772821,
-0.3216852,
0.04416196,
-0.0840197... |
Distribution of ether lipids and composition of the archaeal community in terrestrial geothermal springs: impact of environmental variables. | Archaea can respond to changes in the environment by altering the composition of their membrane lipids, for example, by modification of the abundance and composition of glycerol dialkyl glycerol tetraethers (GDGTs). Here, we investigated the abundance and proportions of polar GDGTs (P-GDGTs) and core GDGTs (C-GDGTs) sa... | 25,142,282 | [
0.3026552,
0.3645363,
-0.1473254,
0.1849995,
-0.4128346,
-0.1058931,
-0.3723434,
0.1974571,
0.08511724,
-0.1753786,
-0.1402472,
-0.4282294,
-0.224496,
0.1489724,
-0.4592457,
-0.09591955,
-0.0457205,
0.1140325,
0.1532223,
0.203899,
0.1541995,
0.4629955,
-0.392314,
0.1172... |
IL-15-dependent CD8+ CD122+ T cells ameliorate experimental autoimmune encephalomyelitis by modulating IL-17 production by CD4+ T cells. | Interleukin-15 (IL-15) is an inflammatory cytokine whose role in autoimmune diseases has not been fully elucidated. Th17 cells have been shown to play critical roles in experimental autoimmune encephalomyelitis (EAE) models. In this study, we demonstrate that blockade of IL-15 signaling by TMβ-1 mAb treatment aggravate... | 25,142,300 | [
-0.3497988,
-0.537148,
-0.1942234,
-0.2598445,
-0.004599874,
-0.1157652,
0.06477206,
0.2752803,
-0.2430046,
-0.3013204,
-0.1725583,
0.2437018,
-0.01584356,
-0.1645484,
-0.1845579,
0.07226951,
-0.4647051,
0.06026926,
-0.3764485,
0.1380106,
-0.01872126,
0.2968442,
-0.006370... |
Potential anticancer agents. I. Synthesis of isoxazole moiety containing quinazoline derivatives and preliminarily in vitro anticancer activity. | 14 new structures of isoxazole-moiety-containing quinazoline derivatives(3a~3n) were synthesized for the first time and characterized by IR, (1)H NMR, (13)C NMR, ESI-MS. Subsequently, their in vitro anticancer activity against A549, HCT116 and MCF-7 cell lines was preliminarily evaluated using the MTT method. Among the... | 25,142,319 | [
-0.2960079,
0.06597556,
-0.1118621,
0.09492179,
0.004762595,
0.3464405,
-0.1165709,
0.4779111,
0.1283309,
-0.01959217,
0.1116662,
0.1552926,
-0.06533024,
-0.02234044,
-0.457339,
-0.05398495,
-0.5412595,
0.2237375,
-0.1102669,
0.3327645,
0.3896481,
0.1780184,
-0.01403831,
... |
The place of four-dimensional ultrasound in evaluating fetal anomalies. | To analyze the capability of four-dimensional surface rendering mode ultrasound (4D SRM USG) in the detection of fetal abnormalities, and also compare it with 2D USG. A total of 1,379 pregnant women were enrolled in the study, and they all underwent 2D USG screening. In the same session, they were all subsequently scre... | 25,142,340 | [
0.1139611,
0.2636815,
0.1521757,
-0.2381717,
0.2172306,
-0.0911037,
-0.1788113,
-0.270951,
0.3959709,
-0.2778448,
0.1548789,
-0.1836779,
-0.2969393,
-0.07746126,
-0.02892812,
0.106198,
-0.4833494,
-0.2159894,
-0.2607886,
-0.6094272,
0.3341433,
0.2316945,
-0.1494053,
0.2... |
Polycyclic aromatic hydrocarbons (PAHs) in Crassostrea rhizophorae and Cathorops spixii from the Caroni Swamp, Trinidad, West Indies. | Dietary exposure to polycyclic aromatic hydrocarbons (PAHs) may pose serious threats to human health. However, within the Caribbean, quantitative assessments regarding the risks associated with dietary PAH exposure remain sparse. This study investigated PAH presence in edible biota from the Caroni Swamp and quantitativ... | 25,142,345 | [
-0.3045315,
-0.2191298,
0.1353007,
-0.2943518,
-0.02716827,
0.008019094,
-0.1583876,
0.09981897,
0.3391028,
-0.007661534,
-0.02182596,
-0.1004387,
-0.1704489,
-0.4042714,
-0.4436257,
-0.2871654,
-0.7309232,
0.2664814,
0.04388169,
-0.01768728,
-0.1301661,
0.458888,
0.11724... |
Response of growth and superoxide dismutase to enhanced arsenic in two Bacillus species. | Species differences in inorganic arsenic tolerance were investigated by comparing the responses of Bacillus subtilis (B. subtilis) and Bacillus thuringiensis (B. thuringiensis) to elevated concentrations of As(III) and As(V). The cell densities in treatments were always lower during the experiment compared to controls,... | 25,142,350 | [
0.2304294,
-0.2295176,
-0.07059654,
0.02712172,
-0.2366266,
-0.1735296,
-0.0973548,
0.218928,
-0.04322386,
-0.1150571,
0.0008439699,
0.2853531,
-0.3895011,
0.3299007,
-0.4098072,
-0.07513718,
0.01480662,
0.3642312,
0.2379487,
0.05144043,
0.5309843,
0.4760204,
-0.1071167,
... |
Surgical management of multilevel cervical spinal stenosis and spinal cord injury complicated by cervical spine fracture. | There are few reports regarding surgical management of multilevel cervical spinal stenosis with spinal cord injury. Our purpose is to evaluate the safety and feasibility of open-door expansive laminoplasty in combination with transpedicular screw fixation for the treatment of multilevel cervical spinal stenosis and spi... | 25,142,353 | [
0.1031598,
-0.08136138,
0.2110003,
0.03424671,
-0.174434,
-0.4801401,
-0.2961823,
-0.02407667,
0.1935636,
0.1713071,
-0.03568367,
-0.06267571,
-0.04756758,
0.03623688,
-0.2599788,
-0.08097773,
-0.2467985,
0.09897694,
-0.1072858,
-0.1774453,
0.02871531,
0.134474,
-0.065270... |
Spatial and temporal control of fungal natural product synthesis. | Despite their oftentimes-elusive ecological role, fungal natural products have, for better or worse, impacted our daily lives tremendously owing to their diverse and potent bioactive properties. This Janus-faced nature of fungal natural products inevitably ushered in a field of research dedicated towards understanding ... | 25,142,354 | [
-0.04410503,
-0.0552423,
-0.01756013,
-0.0971944,
-0.07194589,
-0.06106265,
-0.05819698,
0.08908588,
0.1023596,
-0.04480727,
-0.05784055,
-0.3403156,
-0.05956347,
-0.06506661,
-0.5959581,
0.1730519,
-0.4066841,
0.190089,
0.2333793,
-0.0656448,
0.2351666,
0.3570084,
-0.475... |
Factors associated with effects of 90Y-ibritumomab tiuxetan in patients with relapsed or refractory low-grade B cell non-Hodgkin lymphoma: single-institution experience with 94 Japanese patients in rituximab era. | This retrospective study analyzes the results of radioimmunotherapy (RIT) with (90)Y-ibritumomab tiuxetan in 94 Japanese patients with relapsed or refractory low-grade B cell non-Hodgkin lymphoma at a single institution. All patients had previously been administered with 1-8 (median 1) regimens of rituximab alone or co... | 25,142,378 | [
-0.2207267,
-0.3309238,
0.1257053,
-0.2040506,
-0.1961644,
-0.2494486,
0.211578,
0.09610948,
-0.0776948,
0.2382246,
0.02768169,
0.09580467,
-0.0940185,
0.1138059,
-0.2192351,
-0.4598119,
0.09977686,
0.333278,
0.177509,
0.03587162,
0.03018535,
0.3398226,
-0.09613482,
0.0... |
Association between bipolar episodes and fluid and electrolyte homeostasis: a retrospective longitudinal study. | Imbalance of fluid and electrolyte homeostasis has been suggested to be associated with the neuropathological processes underlying bipolar disorder. However, longitudinal data regarding the association of bipolar episodes with fluid balance are still lacking. We hypothesized that mania may be associated with a relative... | 25,142,404 | [
-0.2046665,
-0.0880145,
-0.2438882,
-0.3851941,
-0.02596868,
-0.3381156,
-0.2049379,
-0.1652033,
-0.2688772,
-0.195829,
0.2366977,
0.4899451,
-0.2935148,
-0.1581167,
-0.0566483,
-0.04162143,
0.1850018,
-0.02947299,
-0.05704793,
-0.1734038,
-0.1770277,
-0.01007722,
-0.2053... |
National and state patterns of teen births in the United States, 1940-2013. | This report presents trends from 1940 through 2013 in national birth rates for teenagers, with particular focus on the period since 1991. The percent changes in rates for 1991-2012 and for 2007-2012 are presented for the United States and for states. Preliminary data for 2013 are shown where available. Tabular and grap... | 25,142,408 | [
-0.4208957,
0.1184445,
-0.1651847,
-0.0670744,
0.05542312,
-0.09011286,
-0.3339512,
-0.06628986,
0.1314173,
0.005282072,
0.2016998,
-0.1235963,
-0.184004,
-0.09768466,
-0.09081884,
-0.01575632,
0.2238203,
0.1843104,
0.199232,
-0.1554047,
0.3261754,
0.4009159,
0.02794453,
... |
Standard individual cognitive behaviour therapy for paediatric obsessive-compulsive disorder: a systematic review of effect estimates across comparisons. | Previous meta-analyses of paediatric obsessive-compulsive disorder (OCD) have shown much higher effect size for standard individual cognitive behaviour therapy (SI-CBT) compared with control conditions than for serotonin reuptake inhibitors (SRIs) compared with placebo. Other factors, such as systematic differences in ... | 25,142,430 | [
0.008110682,
0.2249072,
-0.3032162,
-0.1347589,
0.2533329,
-0.3598111,
-0.200045,
-0.1322446,
-0.02665025,
-0.1746582,
-0.05806768,
0.5205575,
-0.2193918,
0.0622235,
-0.3567051,
-0.1391193,
-0.2585662,
0.4129915,
-0.2955234,
0.3337158,
0.05826812,
0.1985797,
-0.1580207,
... |
Pharyngeal transit in patients with chronic progressive external ophthalmoplegia. | A common presentation of mitochondrial myopathies is chronic progressive external ophthalmoplegia (CPEO). Dysphagia is a complaint in about 50% of cases. This investigation evaluated pharyngeal transit in patients with CPEO. Videofluoroscopic swallowing evaluation was performed with paste, liquid and solid boluses in 1... | 25,142,449 | [
-0.367668,
-0.1619078,
-0.1039293,
-0.1081482,
0.008992629,
-0.3220564,
0.05163614,
-0.1434591,
0.1272641,
-0.04844461,
0.3015614,
0.3469789,
-0.09455667,
-0.03293163,
-0.09938139,
0.1763949,
-0.6762892,
0.1003719,
-0.5304167,
-0.06934568,
0.1839368,
0.1993117,
0.2287571,... |
Adipokines: a link between obesity and dementia? | Being overweight or obese, as measured with body-mass index or central adiposity (waist circumference), and the trajectory of body-mass index over the life course have been associated with brain atrophy, white matter changes, disturbances of blood-brain barrier integrity, and risk of all-cause late-onset dementia and A... | 25,142,458 | [
-0.1297351,
-0.07415582,
0.07965798,
-0.244251,
0.2981612,
-0.2001174,
-0.09530604,
0.1343099,
0.01880315,
0.2383287,
-0.1772873,
-0.04725524,
0.1237007,
-0.1763053,
-0.4866605,
0.0644777,
-0.1648168,
0.2667907,
0.03903016,
0.03227457,
-0.1367271,
0.1363541,
-0.1482835,
... |
Mechanisms of exercise intolerance in global initiative for chronic obstructive lung disease grade 1 COPD. | The purpose of this study was to determine if a dissociation existed between respiratory drive, as estimated by diaphragmatic electromyography (EMGdi), and its pressure-generating capacity during exercise in mild chronic obstructive pulmonary disease (COPD) and whether this, if present, had negative sensory consequence... | 25,142,487 | [
-0.2243425,
-0.1216986,
0.04243593,
0.08096179,
-0.005317924,
-0.3093714,
-0.2099287,
-0.4537228,
-0.06003483,
-0.3653257,
-0.2019707,
-0.4210974,
-0.317211,
-0.2323298,
-0.05555602,
-0.242193,
-0.6021635,
0.4148442,
-0.2492905,
-0.2428809,
-0.5028853,
-0.01079474,
0.1720... |
De novo use of generic tacrolimus in liver transplantation - a single center experience with one-yr follow-up. | Use of generic tacrolimus in liver transplantation (LT) could result in cost savings. Generic tacrolimus has been shown to be bioequivalent to innovator tacrolimus in healthy volunteers and renal transplant patients. There are limited data on the de novo use of generic tacrolimus in LT. This study aimed to determine wh... | 25,142,496 | [
-0.2581845,
0.02878836,
-0.1135019,
0.219465,
0.09255646,
-0.1772228,
-0.01606193,
-0.142648,
-0.1176577,
0.052618,
-0.004233003,
-0.3594475,
0.0385178,
0.4614449,
-0.737663,
-0.2187303,
-0.0681519,
-0.3488822,
-0.2529331,
0.07519925,
0.003429172,
0.1852549,
-0.3574831,
... |
Why do satellite imageries show exceptionally high chlorophyll in the Gulf of Mannar and the Palk Bay during the Norteast Monsoon? | The Gulf of Mannar (GoM) and the Palk Bay (PB) are two least studied marine environments located between India and Sri Lanka. Exceptionally high chlorophyll a concentration in the GoM and the PB during the Northeast Monsoon (November-February) is a consistent feature in satellite imageries, which has been attributed to... | 25,142,503 | [
-0.126989,
-0.08482061,
0.2687891,
-0.1702983,
-0.2167733,
-0.159359,
-0.3748019,
0.01407239,
-0.001946446,
-0.08400323,
-0.03717471,
0.1017839,
0.3503583,
0.2544845,
-0.3429265,
-0.05508689,
-0.5114614,
0.2463011,
0.009179275,
-0.02822338,
0.3013337,
0.2737075,
-0.116750... |
Determination of organochlorine pesticide concentrations in flathead mullet (Mugil cephalus) caught from the western Black Sea coast of Turkey. | The objective of this study was to determine the levels of 14 organochlorine pesticides (OCPs) in flathead mullet (Mugil cephalus) caught from the western Black Sea coast of Turkey. The fish samples were caught from five different locations of the western Black Sea coast of Turkey in August 2009. Organochlorine pestici... | 25,142,504 | [
-0.09799948,
0.25726,
0.1107007,
-0.0424048,
0.1524722,
-0.06597473,
-0.3652606,
0.06371953,
-0.1147319,
0.3212785,
0.2325999,
0.1122755,
-0.01499128,
0.07366304,
-0.2753426,
-0.2022377,
-0.4391145,
0.4481636,
0.2305694,
0.1995199,
-0.04830614,
0.3558844,
0.1175576,
-0.... |
The life and times of Ferruccio Ritossa. | Ferruccio Ritossa wrote these lines only a few months before he died, as a preface to a book he wanted to write and that, unfortunately, we will never be able to read. It was to be the story of his life, an amazing story indeed. With this article, we want to take a picture of Ferruccio's life, a mosaic of events, facts... | 25,142,515 | [
-0.07732356,
-0.1390776,
-0.07892697,
-0.0661793,
0.1878269,
-0.2303818,
-0.3198813,
-0.2319022,
-0.1759475,
-0.133868,
-0.1030129,
0.3583133,
0.115157,
-0.03710318,
-0.5931718,
-0.2532424,
0.1149029,
-0.1061101,
-0.1345255,
0.03255409,
0.1113566,
0.04518658,
-0.08461528,... |
Progressive promoter element combinations classify conserved orthogonal plant circadian gene expression modules. | We aimed to test the proposal that progressive combinations of multiple promoter elements acting in concert may be responsible for the full range of phases observed in plant circadian output genes. In order to allow reliable selection of informative phase groupings of genes for our purpose, intrinsic cyclic patterns of... | 25,142,519 | [
-0.08275748,
0.3630598,
-0.01213966,
-0.06016919,
0.04862036,
-0.2813382,
-0.2012425,
-0.1931992,
0.2079215,
-0.1463778,
-0.08480443,
-0.075781,
0.1085533,
0.0657146,
-0.3689959,
0.2066907,
-0.2413357,
0.1574093,
0.01447943,
-0.0258465,
0.4317679,
0.2636897,
-0.0668022,
... |
Counterintuitive properties of the fixation time in network-structured populations. | Evolutionary dynamics on graphs can lead to many interesting and counterintuitive findings. We study the Moran process, a discrete time birth-death process, that describes the invasion of a mutant type into a population of wild-type individuals. Remarkably, the fixation probability of a single mutant is the same on all... | 25,142,521 | [
-0.03047589,
-0.2629828,
-0.1111973,
0.2058696,
0.3343962,
-0.3016495,
-0.1825994,
0.07958617,
0.1778695,
-0.1673398,
-0.1232919,
0.08411187,
-0.00124197,
0.130432,
-0.2827655,
-0.2504679,
-0.2598797,
-0.008355781,
-0.08504263,
0.1996361,
0.5353679,
0.3896659,
-0.08063444... |
The effect of glass-forming sugars on vesicle morphology and water distribution during drying. | Cryopreservation requires that stored materials be kept at extremely low temperatures and uses cryoprotectants that are toxic to cells at high concentrations. Lyopreservation is a potential alternative where stored materials can remain at room temperatures. That storage process involves desiccating cells filled with sp... | 25,142,522 | [
-0.3559061,
-0.01565775,
-0.4247055,
-0.1466629,
-0.05903683,
-0.1763474,
-0.04191603,
0.1861985,
0.1920161,
0.1561869,
0.1684832,
0.00124675,
-0.4698739,
-0.05687871,
-0.1391743,
-0.1672048,
-0.2139309,
0.08522113,
-0.02583688,
0.02630579,
0.3348575,
0.3686487,
-0.185824... |
[Hypothermia and memory disturbance as initial manifestations associated with lesions of the diencephalon in a patient with anti-aquaporin 4 antibody-associated disorder: a case report]. | A 69-year-old woman was admitted due to gradual progression of daytime sleepiness and forgetfulness over a period of approximately 1 month. Bradycardia and hypothermia were observed on admission, and neurological examination revealed memory disturbance, mild dysarthria, and bradykinesia. Fluid-attenuated inversion reco... | 25,142,537 | [
-0.1661534,
-0.06682426,
0.01191152,
-0.241628,
-0.03350991,
-0.3639832,
-0.2305908,
-0.3194203,
-0.03164846,
-0.03945846,
0.3917629,
0.5866053,
0.1881979,
-0.07809314,
0.1250233,
-0.2774672,
-0.2109206,
0.1527233,
-0.0007025678,
-0.1475533,
0.0386749,
0.04715978,
-0.2891... |
Periodic leg movements during sleep are associated with polymorphisms in BTBD9, TOX3/BC034767, MEIS1, MAP2K5/SKOR1, and PTPRD. | To examine association between periodic leg movements (PLM) and 13 single nucleotide polymorphisms (SNPs) in 6 loci known to increase risk of restless legs syndrome (RLS). Stanford Center for Sleep Sciences and Medicine and Clinical Research Unit of University of Wisconsin Institute for Clinical and Translational Resea... | 25,142,570 | [
0.01863542,
-0.1782774,
0.03619892,
-0.2634235,
-0.2005584,
-0.2310714,
0.02137608,
0.1952216,
0.1061909,
-0.2460561,
0.2798885,
0.3219975,
0.0456855,
0.1009871,
-0.2975675,
-0.1817411,
-0.4956473,
-0.2433171,
0.3783621,
-0.06371301,
-0.1592181,
0.3126684,
-0.01132834,
... |
Which adenomas are detected by fecal occult blood testing? A state-wide analysis from Bavaria, Germany. | Guaiac-based fecal occult blood tests (gFOBTs) are the most widely used noninvasive tests for colorectal cancer screening. While it is well known that they detect only a minority of colorectal adenomas, evidence for the characteristics of adenomas associated with detection is sparse. We derived estimates of the positiv... | 25,142,576 | [
0.1663485,
-0.06910233,
-0.2219471,
-0.3038191,
0.2051405,
-0.2830188,
-0.02129055,
0.1363595,
0.01572055,
-0.04640367,
-0.05393365,
0.2965939,
-0.06990952,
-0.25793,
-0.1601852,
0.1717901,
-0.4436278,
0.296021,
0.2229197,
0.00147313,
0.2390007,
0.3126525,
-0.2888718,
0... |
Comprehensive analysis of herpes simplex virus 1 (HSV-1) entry mediated by zebrafish 3-O-Sulfotransferase isoforms: implications for the development of a zebrafish model of HSV-1 infection. | Binding of herpes simplex virus 1 (HSV-1) envelope glycoprotein D (gD) to the receptor 3-O-sulfated heparan sulfate (3-OS HS) mediates viral entry. 3-O-Sulfation of HS is catalyzed by the 3-O-sulfotransferase (3-OST) enzyme. Multiple isoforms of 3-OST are differentially expressed in tissues of zebrafish (ZF) embryos. H... | 25,142,596 | [
0.1857183,
-0.213765,
-0.1136432,
0.1378096,
-0.1580513,
-0.2978404,
0.1935562,
-0.007447795,
-0.1277498,
-0.09365112,
0.1060088,
-0.1196898,
-0.3205891,
-0.09338038,
-0.3906291,
0.3076406,
-0.400218,
0.286353,
0.2801974,
0.09297473,
-0.0275792,
0.1907647,
-0.2048841,
0... |
Immunodeficient mouse models with different disease profiles by in vivo infection with the same clinical isolate of enterovirus 71. | Like poliovirus infection, severe infection with enterovirus 71 (EV71) can cause neuropathology. Unlike poliovirus, EV71 is often associated with hand-foot-and-mouth disease (HFMD). Here we established three mouse models for experimental infection with the same clinical isolate of EV71. The NOD/SCID mouse model is uniq... | 25,142,603 | [
0.04414255,
-0.4506933,
-0.08006287,
-0.2199862,
0.152656,
-0.09334861,
-0.03423766,
0.09054783,
-0.2146485,
-0.1482284,
-0.08984101,
-0.09499879,
0.3469827,
0.187834,
-0.1390925,
-0.2955983,
-0.06994983,
-0.2833905,
-0.1490815,
0.1860663,
-0.109347,
0.4472981,
-0.1629625... |
Intrabronchial infection of rhesus macaques with simian varicella virus results in a robust immune response in the lungs. | Varicella-zoster virus (VZV) is the etiological agent of varicella (chickenpox) and herpes zoster (shingles). Primary VZV infection is believed to occur via the inhalation of virus either in respiratory droplets or from shedding varicella lesions or by direct contact with infectious vesicular fluid. However, the ensuin... | 25,142,604 | [
0.02474484,
-0.1979906,
-0.5446283,
-0.3013322,
0.0454996,
-0.4003396,
-0.3974961,
-0.0984474,
-0.1733272,
0.01349234,
0.1542289,
-0.2129386,
-0.1922029,
0.1429081,
-0.41249,
-0.1163175,
-0.1963086,
-0.2367726,
0.3030792,
0.2044474,
0.3946768,
0.3556378,
-0.1850518,
-0.... |
Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo. | Over the past 5 years, a new generation of highly potent and broadly neutralizing HIV-1 antibodies has been identified. These antibodies can protect against lentiviral infection in nonhuman primates (NHPs), suggesting that passive antibody transfer would prevent HIV-1 transmission in humans. To increase the protective ... | 25,142,607 | [
-0.01988109,
-0.05331563,
-0.3531394,
-0.07749492,
0.1867427,
0.1652044,
0.02809392,
0.1501883,
0.1234865,
-0.04585833,
0.2743846,
0.02037952,
0.234359,
0.133574,
-0.2394823,
-0.2672293,
-0.3679777,
-0.1227916,
-0.2350652,
0.1996672,
-0.003707828,
0.3917169,
-0.0192702,
... |
Systematic review of the multidimensional fatigue symptom inventory-short form. | Fatigue is a subjective complaint that is believed to be multifactorial in its etiology and multidimensional in its expression. Fatigue may be experienced by individuals in different dimensions as physical, mental, and emotional tiredness. The purposes of this study were to review and characterize the use of the 30-ite... | 25,142,703 | [
-0.1927862,
-0.002660641,
0.05342983,
-0.3375309,
-0.1069394,
-0.2837897,
-0.05765326,
0.1859345,
-0.1273168,
-0.2986232,
0.2189239,
-0.002595824,
-0.1257185,
-0.03652947,
-0.07843043,
-0.4626677,
-0.1945197,
0.05029149,
-0.02846887,
0.1055073,
-0.3361423,
-0.01576904,
-0... |
Effects of ventilation rate per person and per floor area on perceived air quality, sick building syndrome symptoms, and decision-making. | Ventilation rates (VRs) in buildings must adequately control indoor levels of pollutants; however, VRs are constrained by the energy costs. Experiments in a simulated office assessed the effects of VR per occupant on perceived air quality (PAQ), Sick Building Syndrome (SBS) symptoms, and decision-making performance. A ... | 25,142,723 | [
-0.1127784,
-0.05358573,
-0.01762055,
0.1587979,
-0.01067095,
0.04205918,
0.03254811,
0.08277535,
0.09462968,
-0.4368614,
0.3207268,
-0.1457802,
-0.1853926,
0.1921593,
0.02149776,
-0.2453865,
-0.5155933,
0.1137925,
-0.0697908,
0.08994006,
-0.372369,
0.6876101,
-0.1757247,... |
Metabolites in safety testing assessment in early clinical development: a case study with a glucokinase activator. | The present article summarizes Metabolites in Safety Testing (MIST) studies on a glucokinase activator, N,N-dimethyl-5-((2-methyl-6-((5-methylpyrazin-2-yl)carbamoyl)benzofuran-4-yl)oxy)pyrimidine-2-carboxamide (PF-04937319), which is under development for the treatment of type 2 diametes mellitus. Metabolic profiling i... | 25,142,735 | [
-0.3224467,
0.2330418,
-0.2268096,
-0.3051907,
0.08335944,
-0.2563322,
-0.2571467,
0.10289,
0.2734832,
-0.1648789,
0.1869193,
-0.02317053,
0.04385744,
0.2361544,
-0.3370452,
0.2355488,
-0.8750765,
0.1176061,
0.1354401,
0.09424798,
0.3676174,
0.2450433,
0.04220397,
0.052... |
Dual cases of type 1 narcolepsy with schizophrenia and other psychotic disorders. | Cases of narcolepsy in association with psychotic features have been reported but never fully characterized. These patients present diagnostic and treatment challenges and may shed new light on immune associations in schizophrenia. Our case series was gathered at two narcolepsy specialty centers over a 9-year period. A... | 25,142,772 | [
0.0728286,
-0.2739489,
-0.1814787,
-0.09808286,
0.1262642,
-0.5246019,
-0.2749549,
0.03765059,
0.09727973,
0.07349236,
0.1337318,
0.2009125,
0.146231,
0.1251722,
0.248903,
-0.06029747,
-0.3708309,
0.06650912,
0.1295911,
-0.09717517,
-0.01366452,
0.4416302,
-0.3877276,
-... |
Comprehensive screening for mutations associated with colorectal cancer in unselected cases reveals penetrant and nonpenetrant mutations. | Germline mutation testing in patients with colorectal cancer (CRC) is offered only to a subset of patients with a clinical presentation or tumor histology suggestive of familial CRC syndromes, probably underestimating familial CRC predisposition. The aim of our study was to determine whether unbiased screening of newly... | 25,142,776 | [
-0.1514885,
-0.06906875,
0.1851467,
-0.3131262,
0.1597624,
-0.3612017,
0.2385816,
0.1890406,
-0.04137838,
-0.01687419,
0.1443701,
0.3807665,
0.138466,
-0.1057254,
-0.04799742,
-0.2240053,
-0.2899555,
-0.1538314,
0.1810128,
-0.007608667,
0.3418987,
0.2130826,
0.01662551,
... |
Adamts1 mediates ethanol-induced alterations in collagen and elastin via a FoxO1-sestrin3-AMPK signaling cascade in myocytes. | A variety of stressors including alcohol (EtOH) are known to induce collagen production and fibrotic diseases. Matrix metalloproteinases (MMP) play an important role in regulating fibrosis, but little is known regarding the relationship between EtOH and MMPs. In addition, the signaling cascades involved in this process... | 25,142,777 | [
-0.05109206,
0.358804,
0.07222385,
0.1382831,
-0.1758371,
-0.03382139,
-0.008138597,
0.195444,
0.2041344,
0.279368,
0.0589407,
0.1061049,
-0.222722,
-0.1851355,
-0.1627073,
0.4117652,
-0.2191639,
0.1338944,
-0.3578124,
0.115588,
0.08255184,
0.119969,
-0.403873,
-0.30531... |
[Organ and kidney function preservation in renal cell carcinoma]. | The organ-preserving partial nephrectomy has increasingly established itself in small unilateral renal tumours (<4 cm) with contralateral healthy kidney and counter gained in recent years in importance. There was found a significantly increased cardiovascular mortality rate and deteriorated quality of life, the more... | 25,142,788 | [
0.03250803,
0.09536428,
-0.4967889,
-0.2168631,
-0.00009738894,
-0.5951863,
0.3430359,
0.2946171,
-0.0237529,
-0.02281781,
-0.03583746,
-0.008973383,
0.08219905,
-0.2380883,
-0.3315578,
-0.198001,
-0.1427235,
0.1281863,
0.1761441,
0.2690665,
0.01932939,
0.1290606,
-0.4068... |
Robust meta-analysis shows that glioma transcriptional subtyping complements traditional approaches. | Gliomas traditionally have been sub-classified based on histopathological observations. However, this approach is subject to inter-observer variability, and histopathological features may not reflect the biological mechanisms that drive tumor growth. High-throughput transcriptional profiling has shown promise in object... | 25,142,794 | [
-0.1231103,
0.1701787,
-0.1832207,
-0.3645845,
-0.07972427,
-0.4049901,
-0.3197309,
0.04260221,
0.2182767,
-0.1436353,
-0.1121128,
0.00336965,
0.06865387,
-0.04062266,
-0.2189022,
-0.01756546,
-0.006224993,
0.1916461,
-0.2476617,
0.1849086,
0.1421976,
0.1940447,
-0.126959... |
High levels of CD4⁺ CTLA-4⁺ Treg cells and CCR5 density in HIV-1-infected patients with visceral leishmaniasis. | Visceral leishmaniasis (VL) in HIV-1-infected patients has been associated with poor immunological recovery and frequent disease relapses. The aim of this study was to analyse the role of T cell populations, Treg cells and CCR5 density in patients with VL compared to HIV-1-infected patients without leishmaniasis. A cro... | 25,142,804 | [
0.2961199,
-0.1158046,
-0.05417595,
0.04655694,
-0.408357,
-0.3353978,
-0.04391462,
-0.13183,
-0.08074737,
-0.005071006,
-0.1576767,
-0.08458754,
-0.001384589,
-0.05898829,
-0.6842816,
-0.3698349,
-0.326495,
0.2091399,
0.07899383,
0.09760737,
-0.1417696,
0.4802332,
0.0352... |
Intranasal drug delivery of olanzapine-loaded chitosan nanoparticles. | The aim of this study was to investigate olanzapine (OZ) systemic absolute bioavailability after intranasal (i.n.) administration in vivo to conscious rabbits. Furthermore, the study investigated the potential use of chitosan nanoparticles as a delivery system to enhance the systemic bioavailability of olanzapine follo... | 25,142,821 | [
0.1331347,
-0.2511385,
-0.1573565,
-0.106259,
-0.01895635,
-0.0714691,
-0.2415423,
0.004422298,
-0.2286433,
-0.3694779,
0.1556318,
-0.1360387,
0.1600639,
0.1145726,
-0.4432532,
-0.02434329,
-0.8627921,
-0.04482181,
0.2739694,
-0.1270999,
0.03705881,
-0.08506614,
-0.000712... |
Improvement in estimated glomerular filtration rate in patients with chronic kidney disease undergoing catheter ablation for atrial fibrillation. | Chronic kidney disease (CKD) and atrial fibrillation (AF) often coexist. We studied the association of CKD with atrial fibrosis and the effect of AF ablation on kidney function. AF patients who had a pre- and postablation serum creatinine and who completed a late gadolinium enhancement cardiac magnetic resonance imagin... | 25,142,836 | [
0.04709088,
0.1922071,
-0.5549957,
-0.212146,
-0.02251414,
-0.2817745,
0.02301274,
-0.06651729,
-0.3193425,
-0.01419262,
-0.2442672,
0.3440599,
-0.07098353,
0.1502351,
-0.01043157,
-0.3460056,
0.008849451,
0.05840287,
0.06435528,
-0.2075118,
-0.3570036,
-0.03108702,
-0.26... |
Age-specific changes in intrinsic breast cancer subtypes: a focus on older women. | Breast cancer (BC) is a disease of aging and the number of older BC patients in the U.S. is rising. Immunohistochemical data show that with increasing age, the incidence of hormone receptor-positive tumors increases, whereas the incidence of triple-negative tumors decreases. Few data exist on the frequency of molecular... | 25,142,841 | [
0.3355711,
-0.07964328,
-0.1232008,
-0.09052735,
-0.3003081,
-0.09135153,
0.271672,
-0.024622,
0.1543477,
0.06349964,
-0.05297341,
0.3270912,
0.02854064,
-0.09660728,
-0.2567065,
-0.2716488,
0.2620106,
0.03919404,
0.0814613,
-0.08771361,
0.302906,
0.2159939,
-0.1881612,
... |
[Ecological executive function characteristics and effects of executive function on quality of life in young adult epileptics]. | To explore the characteristics of ecological executive function in young adults with idiopathic or probably symptomatic epilepsy and examine the effects of executive function on quality of life. Fifty-five epileptics (EP) and 39 matched healthy controls (HC) aged 18-44 years at our hospital were selected. The differenc... | 25,142,848 | [
0.2224877,
0.3458816,
0.1334224,
-0.2228287,
0.01706032,
-0.4440641,
-0.5035707,
-0.2760969,
-0.2940607,
-0.1837974,
-0.09910669,
0.6040017,
0.03084679,
0.0372126,
-0.1401254,
-0.1801789,
-0.01315071,
0.378768,
0.08487204,
0.04637748,
-0.4642023,
0.294936,
0.2403715,
-0... |
[Surgical correction of congenital vertical talus by one-stage comprehensive soft-tissue release and peritalar reduction incorporating tibialis anterior transfer]. | To evaluate the surgical efficacies of one-stage comprehensive soft-tissue release and peritalar reduction incorporating tibialis anterior transfer (CSTR-PTR-TAT) in patients with congenital vertical talus (CVT) before the age of 4 years. Thirty-five feet of 21 children with true congenital vertical talus were underwen... | 25,142,853 | [
0.09934135,
0.09318895,
0.262202,
-0.3139582,
-0.0848698,
-0.3269099,
0.00803633,
0.3469015,
0.2002653,
0.1607509,
0.09286083,
0.1590533,
0.07594483,
0.2169634,
-0.5161334,
-0.5031657,
-0.3215728,
-0.2064206,
0.1587672,
-0.08926442,
-0.04937384,
0.2671698,
-0.233912,
-0... |
[Analysis of prognostic factors for patients with traumatic acute subdural hematomas treated by surgery]. | To analyze the factors correlated with the surgical prognosis of patients with traumatic acute subdural hematoma (ASDH). A total of 117 surgical patients for traumatic ASDH between January 2007 and August 2012 were retrospectively reviewed. The clinical factors correlated with prognosis were statistically analyzed.Glas... | 25,142,860 | [
0.2062396,
-0.0436662,
-0.2799521,
-0.2805028,
-0.1656286,
-0.1417099,
-0.365617,
0.07226013,
-0.3523615,
-0.02861163,
0.007356936,
-0.04523597,
-0.4476738,
-0.2180512,
-0.1914669,
0.1209292,
-0.2064654,
0.3604381,
0.1575745,
0.1420536,
0.1137124,
-0.02486304,
0.02130252,... |
Simultaneous monitoring of cerebral metal accumulation in an experimental model of Wilson's disease by laser ablation inductively coupled plasma mass spectrometry. | Neuropsychiatric affection involving extrapyramidal symptoms is a frequent component of Wilson's disease (WD). WD is caused by a genetic defect of the copper (Cu) efflux pump ATPase7B. Mouse strains with natural or engineered transgenic defects of the Atp7b gene have served as model of WD. These show a gradual accumula... | 25,142,911 | [
-0.1989189,
-0.0916669,
-0.5729738,
-0.2098463,
0.3124854,
-0.4113866,
0.01498168,
-0.05466564,
-0.1540022,
0.2647377,
-0.0436993,
0.2142265,
0.2544277,
-0.1243742,
-0.6044703,
0.1388523,
0.2417794,
0.07792268,
-0.168042,
0.363317,
0.408134,
0.2988642,
-0.13188,
0.01377... |
Monocyte-derived dendritic cells from HLA-B27+ axial spondyloarthritis (SpA) patients display altered functional capacity and deregulated gene expression. | This study aimed to compare the functional capacity and gene expression profile of monocyte-derived dendritic cells (MD-DCs) in HLA-B27+ axial spondyloarthritis (SpA) patients and healthy controls. MD-DCs were differentiated with interleukin 4 (IL-4) and granulocyte-macrophage colony-stimulating factor (GM-CSF) for sev... | 25,142,923 | [
-0.1272941,
0.2641737,
-0.02035453,
0.3090937,
-0.009121547,
-0.5538474,
-0.3702213,
0.2735379,
-0.2880004,
0.05418969,
0.2102313,
0.07339901,
0.102497,
-0.291158,
-0.6652097,
0.3366014,
-0.1973578,
-0.1073186,
-0.5959899,
0.411111,
0.8396974,
0.3731636,
-0.2746465,
0.0... |
Fate of xylem-transported 11C- and 13C-labeled CO2 in leaves of poplar. | In recent studies, assimilation of xylem-transported CO2 has gained considerable attention as a means of recycling respired CO2 in trees. However, we still lack a clear and detailed picture on the magnitude of xylem-transported CO2 assimilation, in particular within leaf tissues. To this end, detached poplar leaves (Po... | 25,142,926 | [
-0.05696845,
0.1525138,
-0.0319333,
0.3268925,
0.2629538,
-0.1057876,
-0.3439672,
-0.0708498,
-0.1125428,
-0.03277647,
0.09515846,
-0.1705081,
0.05872341,
-0.01561317,
-0.5496024,
-0.07096145,
-0.06100692,
0.08920019,
0.2281954,
0.3524739,
0.3324783,
0.7282614,
-0.0278448... |
The economic cost of a poor start to life. | A primary challenge for nutrition policy in low-income settings is to position nutrition as an investment rather than simply as a form of social spending that governments grant poor people to the degree that governments prioritize equity. Various economic models have produced estimates of the economic costs of malnutri... | 25,142,929 | [
-0.3317104,
0.02377051,
-0.1516993,
-0.1624573,
0.2133367,
0.1576528,
-0.08003931,
0.09855766,
0.06328148,
-0.03397268,
-0.03204381,
0.08744274,
-0.2445155,
0.0660444,
-0.4306917,
-0.2628649,
-0.0246044,
0.06341124,
-0.3002983,
-0.03463349,
-0.02954334,
0.5729022,
-0.1134... |
The effect of late gestation foetal hypoglycaemia on cardiovascular and endocrine function in sheep. | An appropriate foetal cardiovascular (CV) response to reduced substrate supply (e.g. oxygen or other nutrients) is vital for growth and development, and may impact on CV control. The prevailing nutritional environment and associated CV changes may influence subsequent CV responses to challenges during late gestation, f... | 25,142,930 | [
0.1724294,
-0.098067,
-0.2900927,
-0.1817621,
0.2021036,
-0.1756191,
-0.3254865,
-0.005056418,
0.03080215,
-0.05385783,
-0.01841255,
0.1727307,
0.05084357,
-0.1356072,
-0.4153075,
-0.1703041,
-0.1545211,
0.397787,
-0.2306744,
0.2015284,
0.03046927,
0.08986266,
-0.1034727,... |
Five new anthraquinones from the seed of Cassia obtusifolia. | A phytochemical investigation on the seeds of Cassia obtusifolia led to the isolation of five new anthraquinones, including one aglycon and four glycosides. The structures were elucidated by analysis of extensive spectroscopic data and the results of acid hydrolysis. All these isolates were evaluated for their inhibito... | 25,142,941 | [
-0.2889726,
0.1711969,
-0.2790251,
0.07155517,
0.193209,
0.3559963,
-0.4024152,
-0.002607147,
0.2776732,
-0.06507358,
0.1300076,
0.02064929,
-0.0189578,
-0.3542157,
-0.1423533,
0.3859965,
-0.5406392,
0.4186852,
0.05198281,
0.07373454,
0.4381469,
0.1501495,
-0.2257072,
-... |
[Renal arteriovenous fistula with a vein aneurysm: a case report]. | A 54-year-old woman presented with abdominal distension. Her medical history was unremarkable. Contrast-enhanced computed tomography (CT) revealed a left renal arteriovenous fistula and a large vein aneurysm, and she was diagnosed with aneurismal-type renal arteriovenous fistula. She was successfully treated with trans... | 25,142,960 | [
-0.1384548,
0.3807006,
-0.2582244,
0.2666096,
0.2351079,
-0.03188265,
-0.4872453,
-0.1604174,
-0.0596658,
-0.03896483,
0.2587897,
0.3310078,
-0.1862776,
-0.2330416,
-0.3266315,
-0.1065363,
-0.1136176,
0.5305152,
0.4087747,
-0.4527628,
-0.04497546,
0.113664,
-0.4479106,
... |
Serological versus molecular typing of surface-associated immune evading polysaccharide antigens-based phenotypes of Staphylococcus aureus. | The aim of this study was to compare the performance of serological versus molecular typing methods to detect capsular polysaccharide (CP) and surface-associated polysaccharide antigen 336 phenotypes of Staphylococcus aureus isolates. Molecular typing of CP types 1, 5 and 8 was carried out using PCR, whereas serologica... | 25,142,964 | [
0.07265481,
-0.003635971,
0.04695373,
-0.3135227,
-0.2019265,
-0.2035775,
-0.2392209,
0.1444959,
0.06342686,
0.1119842,
-0.05464324,
0.2403312,
0.06290781,
-0.1656078,
0.06500603,
-0.1927935,
-0.01281172,
0.2960625,
0.1036565,
-0.004576069,
0.2268969,
0.2553197,
-0.252906... |
Novel treatment strategies for schizophrenia from improved understanding of genetic risk. | Recent years have seen significant advances in our understanding of the genetic basis of schizophrenia. In particular, genome-wide approaches have suggested the involvement of many common genetic variants of small effect, together with a few rare variants exerting relatively large effects. While unequivocal identificat... | 25,142,969 | [
0.08535912,
0.0833805,
0.2053322,
-0.4431138,
0.05776853,
-0.2260536,
-0.09104393,
-0.1239318,
-0.04319263,
0.1431634,
0.04768574,
0.07361995,
0.0372345,
0.02889436,
-0.3148214,
0.02189745,
-0.3615255,
0.2049321,
0.03753887,
0.04873396,
-0.07503261,
0.3399827,
-0.1088084,... |
[Relationship between cyclooxygenase-2 in nasopharyngeal carcinoma and cervical lymph node metastasis]. | To explore the expression of cyclooxygenase-2 (COX-2) in lowly differentiated nasopharyngeal carcinoma and examine its relationship with cervical lymph node metastasis. On the basis of COX expression, a total of 104 patients with lowly differentiated squamous cell carcinoma NPC were divided into 2 groups of COX-2 high-... | 25,142,993 | [
0.1069808,
-0.1201053,
-0.2723601,
0.03768438,
-0.09909971,
-0.3511716,
-0.08423567,
0.09364384,
0.08029387,
0.009875945,
0.1283266,
0.04587396,
0.1067749,
-0.1888011,
-0.3945306,
-0.2990394,
0.04268729,
0.1276509,
0.05711199,
0.3032499,
0.06426481,
0.2263428,
-0.3717072,... |
[Expressions of Dab2 and ERK1 in esophageal carcinoma tissues and their clinical significance]. | To explore the expressions of protein and mRNA of disabled-2 (Dab2) and extracellular signal-regulated kinase1 (ERK1) in esophageal squamous cell carcinoma tissue (ESCC) and their clinical significance. The expressions of protein and mRNA of Dab2 and ERK1 were detected in ESCC (n = 59), atypical hyperplasia (n = 27) an... | 25,142,995 | [
-0.1743895,
-0.2061781,
-0.319873,
-0.1592553,
0.08300326,
-0.4110848,
-0.01955885,
0.3782556,
-0.05197433,
0.3270371,
0.2871129,
0.1164409,
0.211067,
-0.3057721,
0.03690883,
-0.3479832,
-0.4818985,
-0.001534439,
0.1452031,
-0.2228783,
0.4821901,
0.1168557,
-0.2070326,
... |
Effects of herbicide-treated host plants on the development of Mamestra brassicae L. caterpillars. | Herbicides are widely used pesticides that affect plants by changing their chemistry. In doing so, herbicides might also influence the quality of plants as food for herbivores. To study the effects of herbicides on host plant quality, 3 plant species (Plantago lanceolata L., P. major L., and Ranunculus acris L.) were t... | 25,143,001 | [
0.08068792,
0.422399,
-0.09364075,
-0.3063326,
0.03726767,
-0.02225645,
-0.3182539,
0.08254431,
0.09790961,
-0.09026805,
0.03033572,
-0.08706156,
0.1858351,
0.1218279,
-0.3516336,
0.08547579,
-0.2592978,
0.4732929,
0.1072162,
-0.1682543,
-0.03783703,
0.5393089,
-0.288693,... |
Liver enzyme elevation during darunavir-based antiretroviral treatment in HIV-1-infected patients with or without hepatitis C coinfection: data from the ICONA foundation cohort. | To investigate differences in liver enzyme elevation (LEE) between HIV-infected patients with and without HCV coinfection who start a darunavir/ritonavir-containing regimen. HIV-infected patients enrolled in the Italian Cohort of Naïve to Antiretrovirals (ICONA) Foundation Study were included if they started darunavir/... | 25,143,024 | [
0.04558407,
0.2065588,
0.05847763,
0.155357,
0.008539545,
-0.2556077,
-0.1164149,
0.1922153,
0.1753342,
-0.07651076,
-0.07093251,
0.09919915,
0.2621955,
0.2311153,
-0.3143691,
-0.3471333,
-0.3270651,
0.1238549,
0.3252524,
0.3166448,
0.2554365,
0.1589123,
-0.3724535,
0.2... |
Time flies: Time of day and social environment affect cuticular hydrocarbon sexual displays in Drosophila serrata. | Recent work on Drosophila cuticular hydrocarbons (CHCs) challenges a historical assumption that CHCs in flies are largely invariant. Here, we examine the effect of time of day and social environment on a suite of sexually selected CHCs in Drosophila serrata. We demonstrate that males become more attractive to females d... | 25,143,030 | [
0.1885262,
0.05220752,
-0.1986215,
0.08547972,
0.124576,
-0.02185216,
-0.09797045,
0.03866033,
0.2007641,
-0.09199417,
-0.004734208,
0.02660154,
-0.04403468,
-0.3770785,
-0.2391406,
-0.1454885,
-0.284412,
0.1691193,
0.2906585,
-0.1516312,
-0.2664719,
0.564439,
-0.1904148,... |
Foster carers influence brood pathogen resistance in ants. | Social organisms face a high risk of epidemics, and respond to this threat by combining efficient individual and collective defences against pathogens. An intriguing and little studied feature of social animals is that individual pathogen resistance may depend not only on genetic or maternal factors, but also on the so... | 25,143,036 | [
0.2391237,
0.02486592,
-0.1475028,
-0.2823439,
0.172055,
-0.1471332,
-0.1175391,
-0.2886595,
-0.06127492,
-0.3976634,
0.03223742,
-0.4513498,
0.1377418,
-0.1963767,
0.03109573,
-0.03238861,
-0.459047,
0.09871082,
-0.1152718,
0.2646445,
-0.2082934,
0.5104339,
-0.1989836,
... |
Tissue cell assisted fabrication of tubular catalytic platinum microengines. | We report a facile platform for mass production of robust self-propelled tubular microengines. Tissue cells extracted from fruits of banana and apple, Musa acuminata and Malus domestica, are used as the support on which a thin platinum film is deposited by means of physical vapor deposition. Upon sonication of the cell... | 25,143,056 | [
-0.1134491,
-0.09055313,
-0.1779645,
0.1522863,
0.1031475,
-0.01955234,
-0.4937135,
0.09851839,
0.1336662,
0.07450645,
0.08796286,
-0.2131663,
0.01010935,
-0.00167237,
-0.6192783,
0.1825462,
-0.2883535,
0.03936862,
-0.03774309,
-0.1900856,
0.3042753,
0.04515718,
-0.349865... |
Size at birth is associated with blood pressure but not insulin resistance in 6-8 year old children in rural Nepal. | Earlier, we reported that antenatal micronutrient supplementation reduced the risk of metabolic syndrome and microalbuminuria among offspring at 6-8 years of age in rural Nepal. In the same birth cohort, we examined associations of size at birth (weight, length and ponderal index), and gestational age, with cardiometab... | 25,143,065 | [
-0.07842663,
-0.09893677,
-0.09501418,
-0.03930445,
0.06960522,
-0.1083098,
-0.2932922,
0.003588623,
0.09651067,
0.1150724,
0.1413326,
-0.08078337,
-0.008360727,
0.04871607,
-0.3094161,
-0.07577935,
-0.1233631,
0.4456606,
-0.01460376,
0.1198665,
-0.5366442,
0.1510546,
-0.... |
Childhood obesity and autonomic dysfunction: risk for cardiac morbidity and mortality. | The epidemic of childhood obesity is becoming a major predictor for risk of cardiovascular diseases (CVD) and mortality during adulthood. Alterations in the morphology of the heart due to obesity could be a predictor for the dysfunction of cardiac autonomic modulation (CAM). A number of epidemiologic studies have evalu... | 25,143,120 | [
-0.2075712,
0.04617599,
-0.1750715,
-0.004816485,
-0.05800134,
-0.2696427,
-0.0005996678,
0.07086173,
-0.2729932,
-0.06459825,
0.05026127,
0.1588843,
0.0550769,
-0.1818444,
-0.4639135,
0.005101657,
-0.3009933,
0.3715559,
0.02556979,
0.1183616,
-0.07735679,
0.3559985,
-0.4... |
Prognostic significance of immunophenotypes and a nodular pattern in primary mediastinal large B-cell lymphoma. | To investigate the clinicopathological and prognostic significance of a nodular pattern and immunophenotypes in primary mediastinal large B-cell lymphoma (PMBL), histopathological features, including a nodular pattern and immunophenotypes, were analyzed in 58 Japanese PMBL patients. The patients were 23 men and 35 wome... | 25,143,126 | [
-0.07371633,
-0.04815759,
-0.006497633,
-0.566012,
-0.3673792,
-0.3174329,
0.1639284,
-0.1627788,
-0.06817751,
0.09551121,
0.1081749,
0.3917317,
0.2605005,
0.2180964,
-0.03849255,
-0.007291401,
-0.1424678,
0.3339402,
0.2027605,
0.2073816,
0.5756307,
0.4163598,
-0.00782094... |
Proteome analysis of early lineage specification in bovine embryos. | During mammalian embryo development, the zygote undergoes embryonic cleavage in the oviduct and reaches the uterus at the morula stage, when compaction and early lineage specification take place. To increase knowledge about the associated changes of the embryonic protein repertoire, we performed a comprehensive proteom... | 25,143,135 | [
0.08460671,
-0.08720586,
-0.1760301,
-0.09883621,
-0.07251652,
-0.04995695,
0.1236615,
-0.02500319,
0.2552082,
-0.1741508,
0.1164388,
-0.1064563,
-0.001127229,
0.01193838,
0.08984485,
0.09561728,
-0.6629362,
0.0304041,
0.1928245,
-0.2377286,
0.5614862,
0.3925098,
-0.08061... |
Naming game on networks: let everyone be both speaker and hearer. | To investigate how consensus is reached on a large self-organized peer-to-peer network, we extended the naming game model commonly used in language and communication to Naming Game in Groups (NGG). Differing from other existing naming game models, in NGG everyone in the population (network) can be both speaker and hear... | 25,143,140 | [
-0.1481107,
0.4922917,
0.1575223,
-0.006409273,
0.3501342,
-0.1561381,
-0.4629273,
0.01439856,
0.04721786,
-0.3168905,
0.1543365,
-0.04179397,
-0.09736551,
-0.127964,
-0.4040026,
0.08453323,
0.04703168,
0.2926591,
0.001055532,
-0.2422297,
0.2464058,
0.3388718,
-0.1438318,... |
Extraordinarily high pseudocapacitance of metal organic framework derived nanostructured cerium oxide. | MOF derived CeO2 showed a pseudocapacitance of 1204 F g(-1) at 0.2 A g(-1), far exceeding its theoretical capacitance (560 F g(-1)). The present study demonstrates that combination of a two-way strategy, controlled nano-architecture and redox active electrolyte additive, could potentially alleviate both low energy dens... | 25,143,153 | [
-0.2194591,
0.3222527,
-0.0742844,
0.1175627,
-0.09390476,
0.1019023,
-0.2726237,
0.002168773,
-0.07722122,
-0.1486201,
-0.1130519,
0.2661395,
0.03132847,
0.1360003,
-0.4574882,
-0.07440829,
-0.1376394,
0.06253847,
-0.1219755,
0.04277439,
-0.1510286,
0.1013658,
-0.0473020... |
[Clinical classification and surgical management of cervicothoracic intraspinal lipomas]. | To explore the clinical classification and surgical management of cervicothoracic intraspinal lipomas. A total of 22 patients with cervicothoracic intraspinal lipomas were analyzed retrospectively with regards to clinical manifestations, radiographic features, intraoperative findings, surgical techniques and follow-ups... | 25,143,160 | [
-0.007722415,
0.08423796,
0.1436699,
-0.3915676,
-0.01457609,
-0.3590775,
-0.3037821,
0.02420552,
0.2984507,
0.3128023,
-0.0001453512,
0.03860829,
0.08627795,
-0.421901,
-0.07787402,
0.06384631,
-0.4877727,
-0.297491,
0.1457325,
-0.09344231,
-0.1238748,
0.3594862,
0.01716... |
[Clinical features and microsurgical treatment of spinal intramedullary cavernoma]. | To explore the clinical features and microsurgical treatment of spinal intramedullary cavernomas (SICs). A total of 21 patients with pathologically confirmed SIC undergoing microsurgical resection of cavernomas at Beijing Tiantan Hospital and Taian Central Hospital from June 2005 to December 2012 were reviewed retrospe... | 25,143,163 | [
0.04451781,
0.39875,
0.1802104,
-0.3465223,
-0.08040313,
-0.04805863,
-0.03882504,
-0.03218687,
0.1555049,
0.2739742,
0.1753251,
0.06149443,
-0.09174978,
-0.394443,
-0.2566812,
-0.1411461,
-0.3065355,
-0.1705995,
0.08804377,
0.3422951,
-0.09016523,
0.2543038,
0.1050668,
... |
Effect of minimally invasive surgery on the risk for surgical site infections: results from the National Surgical Quality Improvement Program (NSQIP) Database. | Surgical site infection (SSI) represents the second most common cause of hospital-acquired infection and the most common type of infection in patients undergoing surgery. However, evidence is scarce regarding the effect of the surgical approach (open surgery vs minimally invasive surgery [MIS]) on the risk for SSIs. To... | 25,143,176 | [
-0.1187956,
0.008081823,
-0.5905552,
-0.2759774,
-0.3891306,
-0.1511233,
-0.1289932,
-0.03800077,
0.0346749,
-0.03379497,
0.2289948,
0.1942539,
0.05419188,
-0.4249281,
-0.1668718,
-0.234855,
-0.05322081,
0.04944417,
0.1291109,
-0.4026456,
-0.1241282,
-0.09174693,
-0.13920... |
Identification of Belgian mosquito species (Diptera: Culicidae) by DNA barcoding. | Since its introduction in 2003, DNA barcoding has proven to be a promising method for the identification of many taxa, including mosquitoes (Diptera: Culicidae). Many mosquito species are potential vectors of pathogens, and correct identification in all life stages is essential for effective mosquito monitoring and con... | 25,143,182 | [
-0.0482755,
0.1572438,
0.1424768,
-0.2168174,
0.02302748,
-0.138366,
0.05265497,
-0.009160942,
0.2566303,
-0.3043755,
-0.1752504,
-0.4191812,
0.1394655,
-0.2984997,
-0.9930931,
-0.2043276,
-0.01295894,
0.3315214,
0.5050189,
-0.01997901,
0.2513451,
-0.0749654,
0.1076653,
... |
The electron is a catalyst. | The electron is an efficient catalyst for conducting various types of radical cascade reaction that proceed by way of radical and radical ion intermediates. But because electrons are omnipresent, catalysis by electrons often passes unnoticed. In this Review, a simple analogy between acid/base catalysis and redox cataly... | 25,143,210 | [
-0.1681191,
-0.005973335,
-0.1200857,
0.07361322,
0.04468099,
-0.2849089,
-0.4167517,
-0.1157125,
0.1702299,
-0.001377329,
0.001248136,
0.1756699,
0.2703429,
0.3060364,
-0.6563176,
-0.2826777,
-0.5888558,
0.00729482,
0.1220814,
-0.07962698,
-0.04748783,
0.08508921,
-0.124... |
A nanoporous two-dimensional polymer by single-crystal-to-single-crystal photopolymerization. | In contrast to the wide number and variety of available synthetic routes to conventional linear polymers, the synthesis of two-dimensional polymers and unambiguous proof of their structure remains a challenge. Two-dimensional polymers-single-layered polymers that form a tiling network in exactly two dimensions-have pot... | 25,143,211 | [
-0.1412567,
0.1544876,
0.1423785,
-0.137643,
0.2160864,
-0.1059808,
-0.5247229,
-0.07836415,
0.4130848,
0.06924144,
-0.10126,
-0.5235614,
-0.01734184,
0.1000026,
-0.1852084,
-0.1126331,
-0.4959761,
0.2461026,
0.02997702,
0.05990031,
0.347097,
0.1853389,
-0.2651046,
-0.0... |
γδ T-cell-rich variants of pityriasis lichenoides and lymphomatoid papulosis: benign cutaneous disorders to be distinguished from aggressive cutaneous γδ T-cell lymphomas. | T cells with a γδ phenotype have been associated with aggressive lymphomas. Yet, inflammatory skin disorders and low-grade lymphoproliferative disorders have rarely been described with a predominant γδ T-cell infiltrate. To review our experience and determine the clinical relevance of the γδ T-cell phenotype in lymphom... | 25,143,223 | [
-0.1320877,
-0.4301881,
-0.4750327,
-0.3896156,
-0.06814508,
-0.4573154,
-0.1818348,
-0.09147695,
-0.03592934,
0.3324449,
0.1615254,
0.307532,
0.07394497,
-0.05994732,
-0.05802318,
-0.1751486,
-0.1596788,
-0.03580249,
0.4166991,
-0.1621653,
0.3352551,
0.4589952,
-0.207980... |
Long-term quality of life after radical prostatectomy: 8-year longitudinal study in Japan. | To assess long-term health-related quality of life in patients undergoing radical prostatectomy. A total of 120 patients with at least 5 years of follow up after radical prostatectomy were included in the present study. Health-related quality of life outcomes were assessed using three questionnaires, the Short Form 36-... | 25,143,229 | [
0.02790335,
-0.1930967,
-0.1308921,
-0.3506809,
-0.2885662,
-0.2587156,
0.1804904,
0.4123301,
-0.1235727,
-0.1209763,
0.2491664,
-0.000684941,
-0.06449969,
-0.133318,
-0.3296098,
-0.2730664,
0.3250177,
0.367545,
0.3660099,
-0.2132897,
0.2480724,
0.3495155,
-0.07593136,
... |
Dimerization of 30Kc19 protein in the presence of amphiphilic moiety and importance of Cys-57 during cell penetration. | Recently, the recombinant 30Kc19 protein, originating from silkworm hemolymph of Bombyx mori has attracted attention due to its cell-penetrating property and potential application as a protein delivery system. However, this observation of penetration across cell membrane has raised questions concerning the interaction ... | 25,143,246 | [
-0.04761374,
-0.2406921,
-0.2375849,
-0.07131508,
-0.06000575,
0.1083333,
-0.2506877,
0.2531391,
0.1856395,
-0.1975924,
0.1427038,
-0.1453295,
-0.001594896,
0.03511894,
-0.4419951,
0.1538711,
-0.2979929,
-0.06265979,
-0.05213377,
-0.00541449,
0.01201329,
0.2396353,
-0.014... |
Collapse of the native structure caused by a single amino acid exchange in human NAD(P)H:quinone oxidoreductase(1.). | Human quinone oxidoreductase 1 (NQO1) is essential for the antioxidant defense system, stabilization of tumor suppressors (e.g. p53, p33, and p73), and activation of quinone-based chemotherapeutics. Overexpression of NQO1 in many solid tumors, coupled with its ability to convert quinone-based chemotherapeutics into pot... | 25,143,260 | [
-0.03448439,
0.2593495,
0.09590722,
-0.2522848,
0.1489601,
-0.3320432,
0.1182146,
0.1469814,
0.2050933,
-0.03616922,
0.08560783,
0.07132085,
0.06225355,
-0.1720175,
-0.4706233,
0.07878284,
-0.4586907,
-0.03255013,
0.1743768,
0.1968741,
0.3078681,
0.1128562,
-0.3474967,
... |
The prognosis of diabetic retinopathy in patients with type 2 diabetes since 1996-1998: the Skaraborg Diabetes Register. | Diabetes mellitus is the main reason for visual impairment among patients of working ages. The aim of this paper was to investigate the prognosis of eye complications in patients with diabetes during 10 years of follow-up and contributing risk factors. Data from ophthalmological records (occurrence of retinopathy and l... | 25,143,261 | [
0.1773856,
-0.2279886,
-0.6147047,
-0.2855013,
0.232962,
-0.4235399,
0.2455058,
0.0455621,
0.1376803,
-0.2879366,
0.1704526,
0.1044934,
-0.01061449,
-0.2864032,
-0.1506084,
0.09542109,
0.009382448,
0.5055481,
0.2816305,
0.1181837,
-0.04321886,
0.4619516,
-0.2297132,
-0.... |
[Recent advances in understanding the innate immune mechanisms and developing new disease resistance breeding strategies against the rice blast fungus Magnaporthe oryzae in rice]. | Rice blast, caused by the fungal pathogen Magnaporthe oryzae, is one of the most destructive diseases in rice. Utilization of resistant cultivars is the most effective and economic strategy against the disease. Recently, rice blast has become an advanced model system for elucidating the molecular mechanisms of plant-fu... | 25,143,273 | [
-0.06858147,
-0.182311,
0.3936256,
-0.2122523,
-0.1949443,
-0.1928742,
0.1336043,
0.1126045,
-0.04818687,
0.06357368,
0.1799026,
0.4436661,
-0.2559552,
-0.06330784,
-0.4282068,
-0.2838595,
-0.5070481,
0.1137406,
0.1141827,
-0.1613126,
0.06284393,
0.3353955,
-0.4192936,
... |
Retinal vasculitis: a novel paradoxical effect of anti-TNFα? | Retinal vasculitis (RV) is extremely rare in spondyloarthritis associated with Crohn's disease. Infliximab, a chimeric monoclonal antibody to tumour necrosis factor (TNF) α, is efficient in spondyloarthritis, Crohn's disease and RV. We present the case of a 41-year-old man with a known history of spondyloarthritis asso... | 25,143,312 | [
-0.006261643,
-0.3170637,
-0.3909715,
0.1121243,
0.2081314,
-0.2271001,
-0.04876405,
0.1035836,
-0.2873293,
-0.2264491,
0.01603618,
0.1969254,
-0.05272903,
-0.1169068,
0.1071234,
-0.1839964,
-0.4966948,
-0.1243553,
0.3105109,
-0.09497903,
0.1553084,
0.4441223,
-0.240062,
... |
Sigmoid volvulus in an adolescent girl: staged management with emergency colonoscopic reduction and decompression followed by elective sigmoid colectomy. | A case of acute sigmoid volvulus in a 14-year-old adolescent girl presenting with acute low large bowel obstruction with a background of chronic constipation has been presented. Abdominal radiograph and CT scan helped in diagnosis. She underwent emergency colonoscopic detorsion and decompression uneventfully. Lower gas... | 25,143,313 | [
-0.04527022,
-0.1442226,
0.1231114,
-0.3937875,
0.08369329,
-0.4081305,
-0.1211703,
-0.2977262,
-0.07895198,
-0.09011304,
-0.08285301,
0.05663814,
-0.4825033,
0.1672626,
-0.1521459,
-0.3047202,
-0.464005,
0.07051522,
-0.02276188,
-0.4757084,
0.07170324,
0.1056291,
-0.2540... |
ACE-inhibition increases podocyte number in experimental glomerular disease independent of proliferation. | The objective of this article is to test the effects of angiotensin-converting enzyme (ACE)-inhibition on glomerular epithelial cell number in an inducible experimental model of focal segmental glomerulosclerosis (FSGS). Although ACE-inhibition has been shown to limit podocyte loss by enhancing survival, little is know... | 25,143,333 | [
-0.1587586,
-0.1790996,
-0.3771272,
-0.3393458,
0.1552248,
-0.1055163,
0.01696674,
0.3419845,
0.06752611,
-0.09069116,
-0.1040968,
0.3195201,
-0.2226088,
-0.2213599,
-0.5008259,
-0.02026115,
-0.2528952,
0.321827,
0.0182991,
0.4787973,
-0.3899769,
-0.01958029,
-0.2275608,
... |
A highly potent agonist to protease-activated receptor-2 reveals apical activation of the airway epithelium resulting in Ca2+-regulated ion conductance. | The airway epithelium provides a barrier that separates inhaled air and its various particulates from the underlying tissues. It provides key physiological functions in both sensing the environment and initiating appropriate innate immune defenses to protect the lung. Protease-activated receptor-2 (PAR2) is expressed b... | 25,143,347 | [
0.2991951,
-0.4985619,
-0.2852309,
-0.1116933,
0.02857182,
0.06038241,
0.1288838,
0.09719201,
0.3346025,
0.2137041,
-0.00438252,
0.3441316,
-0.1021727,
0.1359212,
-0.4975209,
-0.05437209,
-0.3797253,
0.1440706,
-0.170748,
0.0240309,
0.2979881,
0.1486131,
-0.04316127,
0.... |
Pericyte contractility controls endothelial cell cycle progression and sprouting: insights into angiogenic switch mechanics. | Microvascular stability and regulation of capillary tonus are regulated by pericytes and their interactions with endothelial cells (EC). While the RhoA/Rho kinase (ROCK) pathway has been implicated in modulation of pericyte contractility, in part via regulation of the myosin light chain phosphatase (MLCP), the mechanis... | 25,143,350 | [
-0.2578269,
0.09398107,
-0.1108542,
-0.3449247,
-0.01001434,
0.0262273,
-0.0862507,
0.1950871,
0.2160623,
0.257767,
-0.004530342,
0.3358529,
-0.4981913,
-0.1569072,
-0.7769663,
0.2741384,
-0.3548452,
-0.002491256,
-0.1844694,
0.219406,
0.1457917,
0.2892861,
0.2012603,
-... |
Proteasome inhibition in skeletal muscle cells unmasks metabolic derangements in type 2 diabetes. | Two-dimensional difference gel electrophoresis (2-D DIGE)-based proteome analysis has revealed intrinsic insulin resistance in myotubes derived from type 2 diabetic patients. Using 2-D DIGE-based proteome analysis, we identified a subset of insulin-resistant proteins involved in protein turnover in skeletal muscle of t... | 25,143,351 | [
0.004961779,
-0.1154394,
0.1033662,
-0.112003,
0.1303135,
-0.1103203,
0.1509358,
0.1604874,
0.4301691,
0.1655331,
0.1160735,
0.03109013,
-0.1593331,
0.06714173,
-0.363168,
0.2765216,
-0.5262195,
0.0608065,
-0.1477646,
0.0462252,
0.01589993,
0.3617018,
-0.1786909,
-0.074... |
Joint analysis of differential gene expression in multiple studies using correlation motifs. | The standard methods for detecting differential gene expression are mostly designed for analyzing a single gene expression experiment. When data from multiple related gene expression studies are available, separately analyzing each study is not ideal as it may fail to detect important genes with consistent but relative... | 25,143,368 | [
0.1214944,
-0.02110645,
-0.05982854,
0.01861213,
0.0828664,
-0.4226889,
-0.310719,
0.02030029,
0.1431998,
-0.2948607,
-0.02567895,
-0.2379882,
0.2484415,
0.1892283,
-0.4472288,
0.1433171,
-0.1010136,
-0.08805087,
-0.2930946,
0.2234003,
0.2195411,
0.01154051,
0.02023002,
... |
Program impact pathway analysis of a social franchise model shows potential to improve infant and young child feeding practices in Vietnam. | By mapping the mechanisms through which interventions are expected to achieve impact, program impact pathway (PIP) analysis lays out the theoretical causal links between program activities, outcomes, and impacts. This study examines the pathways through which the Alive & Thrive (A&T) social franchise model is i... | 25,143,372 | [
-0.1773728,
0.02316499,
0.145725,
-0.2500306,
0.2364427,
-0.2176519,
-0.03749092,
-0.1984061,
0.1161766,
-0.2045725,
-0.2078156,
0.03900856,
-0.5769579,
-0.1773405,
-0.3884402,
-0.197891,
-0.7195818,
0.07320417,
-0.1358543,
0.01611311,
0.4712234,
0.4521643,
-0.1687956,
... |
Fbxo45 inhibits calcium-sensitive proteolysis of N-cadherin and promotes neuronal differentiation. | Fbxo45 is an atypical E3 ubiquitin ligase, which specifically targets proteins for ubiquitin-mediated degradation. Fbxo45 ablation results in defective neuronal differentiation and abnormal formation of neural connections; however, the mechanisms underlying these defects are poorly understood. Using an unbiased mass sp... | 25,143,387 | [
-0.2405873,
0.03151424,
0.05015574,
-0.2740275,
-0.04863305,
-0.1422152,
-0.1722328,
0.2142679,
0.2298014,
0.2949499,
0.1106112,
0.5837367,
-0.1665639,
-0.1733838,
-0.1500686,
0.06961551,
-0.5881426,
0.05792287,
-0.3184022,
-0.1279465,
-0.0337263,
0.3388506,
0.0462039,
... |
The actin regulators Enabled and Diaphanous direct distinct protrusive behaviors in different tissues during Drosophila development. | Actin-based protrusions are important for signaling and migration during development and homeostasis. Defining how different tissues in vivo craft diverse protrusive behaviors using the same genomic toolkit of actin regulators is a current challenge. The actin elongation factors Diaphanous and Enabled both promote barb... | 25,143,400 | [
0.02485522,
-0.006684639,
-0.373425,
-0.04503107,
0.154092,
-0.1476769,
-0.08144382,
0.03560235,
0.2127881,
-0.1062774,
-0.06502728,
-0.1514984,
-0.1434819,
-0.2740319,
-0.6366677,
0.3282928,
-0.5675653,
0.0496456,
-0.1436391,
-0.009612131,
0.5409896,
0.1078382,
-0.142065... |
Regulation of microtubule-based transport by MAP4. | Microtubule (MT)-based transport of organelles driven by the opposing MT motors kinesins and dynein is tightly regulated in cells, but the underlying molecular mechanisms remain largely unknown. Here we tested the regulation of MT transport by the ubiquitous protein MAP4 using Xenopus melanophores as an experimental sy... | 25,143,402 | [
0.06439061,
-0.1084438,
-0.2899123,
-0.2631882,
-0.04896085,
-0.3642794,
0.01566262,
0.3525097,
-0.09099233,
-0.04751977,
0.08797194,
0.05338589,
-0.2595958,
0.01751316,
-0.3174267,
0.2050817,
-0.3818597,
-0.02070875,
0.2977033,
-0.4069487,
0.453113,
-0.04096503,
-0.05522... |
Two Dictyostelium tyrosine kinase-like kinases function in parallel, stress-induced STAT activation pathways. | When Dictyostelium cells are hyperosmotically stressed, STATc is activated by tyrosine phosphorylation. Unusually, activation is regulated by serine phosphorylation and consequent inhibition of a tyrosine phosphatase: PTP3. The identity of the cognate tyrosine kinase is unknown, and we show that two tyrosine kinase-lik... | 25,143,406 | [
0.2221465,
0.09800565,
0.0979171,
-0.3318953,
-0.274086,
0.1163032,
0.1944045,
0.1623303,
0.007112397,
0.08744963,
0.08131618,
-0.03335139,
-0.5863897,
0.09801418,
-0.3067866,
-0.361764,
0.1563824,
-0.03541593,
-0.01425045,
0.06795141,
0.5074776,
0.2209154,
-0.03830082,
... |
Systematic lipidomic analysis of yeast protein kinase and phosphatase mutants reveals novel insights into regulation of lipid homeostasis. | The regulatory pathways required to maintain eukaryotic lipid homeostasis are largely unknown. We developed a systematic approach to uncover new players in the regulation of lipid homeostasis. Through an unbiased mass spectrometry-based lipidomic screening, we quantified hundreds of lipid species, including glycerophos... | 25,143,408 | [
0.06823207,
-0.1352773,
0.09079045,
-0.203752,
-0.04163306,
-0.04836708,
0.04441606,
0.2876924,
0.1274324,
-0.1938308,
0.1629815,
-0.2583048,
-0.2855194,
0.1021748,
-0.5563617,
0.2272517,
-0.4390434,
-0.1064317,
-0.001240769,
-0.03195919,
0.09290686,
0.3557014,
-0.0921665... |
A current understanding of vascular calcification in CKD. | Patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) have significant cardiovascular morbidity and mortality that is in part due to the development of vascular calcification. Vascular calcification is an active, highly regulated process that shares many similarities with normal bone formation. ... | 25,143,458 | [
-0.365317,
0.1862685,
0.001732936,
-0.0622819,
-0.1276877,
-0.2032636,
-0.02611177,
0.4335215,
0.2337957,
0.1472934,
-0.03223974,
0.2251002,
-0.2059759,
-0.07462523,
-0.4251005,
-0.3784009,
-0.1187189,
-0.05254272,
0.1037387,
0.1722668,
-0.1524989,
0.2777705,
-0.3026045,
... |
High-resolution imaging of dietary lipids in cells and tissues by NanoSIMS analysis. | Nanoscale secondary ion MS (NanoSIMS) imaging makes it possible to visualize stable isotope-labeled lipids in cells and tissues at 50 nm lateral resolution. Here we report the use of NanoSIMS imaging to visualize lipids in mouse cells and tissues. After administering stable isotope-labeled fatty acids to mice by gavage... | 25,143,463 | [
-0.01823034,
-0.1033724,
-0.3737527,
-0.1953374,
0.2947547,
0.01323993,
0.03860186,
0.1905273,
-0.07411151,
-0.04196965,
-0.1041909,
-0.112425,
-0.002128548,
-0.1239395,
-0.3830846,
-0.01963077,
-0.8940967,
-0.309427,
0.1680401,
0.04670506,
-0.03226851,
0.2850453,
0.11244... |
Fodinomyces uranophilus gen. nov. sp. nov. and Coniochaeta fodinicola sp. nov., two uranium mine-inhabiting Ascomycota fungi from northern Australia. | Seven acidophilic/acidotolerant fungal strains were characterized from samples of process waters (raffinate) at one of Australia's largest uranium mines, the Ranger Mine in Northern Territory. They were isolated from raffinate, which typically were very acidic (pH 1.7-1.8) and contained high concentrations of total dis... | 25,143,478 | [
-0.1388603,
-0.3100806,
0.2694609,
0.1881596,
0.006635453,
-0.04208023,
-0.238816,
0.03466265,
-0.04309114,
0.04000027,
0.1429702,
-0.2621524,
0.2576265,
0.02789867,
-0.01517349,
-0.2784123,
-0.2378884,
0.1856439,
0.4618082,
-0.2817344,
-0.0198015,
0.2355154,
-0.1781506,
... |
A comparison of concentric and eccentric glenospheres in reverse shoulder arthroplasty: a randomized controlled trial. | Inferior scapular notching following reverse shoulder arthroplasty is due to mechanical impingement and, in some studies, has been associated with poorer functional scores, lower patient satisfaction, and more limited shoulder motion. We aimed to test the hypothesis that inferior positioning of the center of rotation w... | 25,143,506 | [
-0.3319417,
0.630576,
-0.07544953,
-0.3578034,
-0.1860624,
-0.5171598,
-0.361888,
0.0862304,
0.1849514,
0.1050091,
0.1346593,
-0.3005077,
-0.2050693,
-0.4527108,
0.09601229,
0.09824041,
-0.2326359,
0.2404523,
-0.1172872,
-0.2971348,
-0.06505491,
-0.01064194,
0.1402459,
... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.