title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Time to symptom resolution in young children treated for pulmonary tuberculosis. | Response to treatment may be useful for diagnostic confirmation of childhood tuberculosis (TB). We aimed to evaluate time to symptom resolution in children treated for pulmonary TB. We compared pulmonary TB cases and noncases, classified by a published diagnostic algorithm, in South African children younger than 2. TB ... | 25,144,794 | [
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Percutaneous microwave ablation for liver tumours adjacent to the marginal angle. | This study was designed to describe the technical essentials of microwave ablation (MWA) for tumours adjacent to the liver marginal angle (LMA) and to determine the feasibility, safety and efficacy of this approach. A total of 22 patients with primary or metastatic liver tumours adjacent to the LMA were enrolled. There... | 25,144,820 | [
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Composition-dependent photoluminescence intensity and prolonged recombination lifetime of perovskite CH3NH3PbBr(3-x)Cl(x) films. | Mixed halide perovskites CH3NH3PbBr3-xClx (x = 0.6-1.2) with different compositions of halogens exhibit drastically changed optical properties. In particular, the thin films prepared with these perovskites demonstrate extraordinary photoluminescence emission intensities and prolonged recombination lifetimes up to 446 n... | 25,144,835 | [
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Psychosocial, educational and communicative interventions for patients with cachexia and their family carers. | Cancer cachexia has a substantial impact on both patients and their family carers. It has been acknowledged as one of the two most frequent and devastating problems of advanced cancer. The impact of cachexia spans biopsychosocial realms. Symptom management in cachexia is fraught with difficulties and globally, there re... | 25,144,837 | [
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[Clinical aspects of the problem of vertebral metastases, possibilities of modern treatment methods, considering especially radiofrequency ablation]. | From 100,000 people in Germany, statistically calculated, 441 males and 350 females suffer from a cancer disease. In about 50 to 80 % of patients with breast or prostate carcinoma bone metastases are registered, which is connected, among others, with a high risk for pathological fractures and other debilitating disease... | 25,144,844 | [
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[The clinical outcome after occipitocervical fusion due to metastases of the upper cervical spine: a consecutive case series and a systematic review of the literature]. | Increasing incidences of osseous metastatic malignancies and higher life expectancy in patients are resulting in a raise of occipitocervical metastases. Those patients with infaust prognosis have a significantly reduced quality of life. In Germany, between 800 and 1680 new cases per year are expected. Treatment algorit... | 25,144,845 | [
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[Outcomes after operative treatment of distal radius fractures - an analysis of 721 patients]. | Treatment strategies in distal radius fractures differ nationally and internationally. Conservative and operative treatment options compete as well as implants, postoperative therapy regimens and the necessity of implant removal. In our institution operative treatment is favoured. In the following the results of 721 su... | 25,144,848 | [
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How confident do you feel? | In this issue of Neuron, Fetsch et al. (2014) show that microstimulation of motion-sensitive neurons in the visual cortex (MT/MST) of primates mimics the addition of sensory information for which the stimulated neurons are selective. Such microstimulation increases the confidence that monkeys have in their decisions ab... | 25,144,869 | [
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Measuring the functional organization of the neocortex at large and small scales. | Sensory cortices are commonly structured topographically; however, the extent to which this organization principle is preserved at the microcircuit level is debated. In this issue of Neuron, Issa et al. (2014) revisit this question by combining calcium imaging in awake mice at large scales encompassing the whole audito... | 25,144,871 | [
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Schizophrenia genetics comes of age. | The new GWAS from the Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014) clearly validates a genetic approach to understanding schizophrenia. The challenge now remains to track down the contributing genes and to develop appropriate models to elucidate the biological effects of the contributing va... | 25,144,873 | [
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Electrochemical control of a non-covalent binding between ferrocene and beta-cyclodextrin. | The forces required for the detachment of ferrocene (Fc) from β-cyclodextrin (βCD) in a single host (βCD)-guest (Fc) complex were investigated using force spectroscopy under electrochemical conditions. The redox state of the guest Fc moiety as well as the structure of the supporting matrix was found to decisively affec... | 25,144,878 | [
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Transfusion-free management of gastrointestinal bleeding: the experience of a bloodless institute. | The Institute for Patient Blood Management and Bloodless Medicine at the Englewood Hospital has considerable experience in managing patients with gastrointestinal bleeding who do not accept blood-derived products. We present our data and experience over the last 8 years in managing such patients. There is paucity of da... | 25,144,897 | [
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C11/C9 helices in crystals of αβ hybrid peptides and switching structures between helix types by variation in the α-residue. | Close-packed helices with mixed hydrogen bond directionality are unprecedented in the structural chemistry of α-polypeptides. While NMR studies in solution state provide strong evidence for the occurrence of mixed helices in (ββ)n and (αβ)n sequences, limited information is currently available in crystals. The peptide ... | 25,144,906 | [
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Study of weathering effects on the distribution of aromatic steroid hydrocarbons in crude oils and oil residues. | The composition and distribution of triaromatic steroid hydrocarbons in oil residues after biodegradation and photo-oxidation processes were detected, and the diagnostic ratios for oil spill identification were developed and evaluated based on the relative standard deviation (RSD) and the repeatability limit. The prefe... | 25,144,907 | [
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The effects of prior authorization policies on medicaid-enrolled children's use of antipsychotic medications: evidence from two mid-Atlantic states. | The purpose of this study was to examine the impact of prior authorization policies on the receipt of antipsychotic medication for Medicaid-enrolled children. Using de-identified administrative Medicaid data from two large, neighboring, mid-Atlantic states from November 2007 through June 2011, we identified subjects &l... | 25,144,909 | [
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Structural Basis of the Toxicity of Chemicals in Cultured Human HeLa Cells. | The newly developed "chemical diversity approach" was used to determine whether or not it is likely that a panel of in vitro cell toxicity assays capable of predicting in vivo eye irritation could be assembled. The analyses, based upon available and validated structure-activity relationship models of toxicity in cultur... | 25,144,928 | [
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Shell-sheddable, pH-sensitive supramolecular nanoparticles based on ortho ester-modified cyclodextrin and adamantyl PEG. | We report a new type of pH-sensitive supramolecular aggregates which possess a programmable character of sequential dePEGylation and degradation. As a platform of designing and building multifunctional supramolecular nanoparticles, a family of 6-OH ortho ester-modified β-cyclodextrin (β-CD) derivatives have been synthe... | 25,144,934 | [
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In situ growth of matchlike ZnO/Au plasmonic heterostructure for enhanced photoelectrochemical water splitting. | In this paper, we report a novel matchlike zinc oxide (ZnO)/gold (Au) heterostructure with plasmonic-enhanced photoelectrochemical (PEC) activity for solar hydrogen production. The matchlike heterostructure with Au nanoparticles coated on the tip of ZnO nanorods is in situ grown on a zinc (Zn) substrate by using a faci... | 25,144,940 | [
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Demographic, anthropometric and socioeconomic characteristics of functional constipation in Eastern Croatia. | Aim of the research is to establish the prevalence of constipation in Osjecko-baranjska County, to establish its specific characteristics and to determine the effect of demographic, anthropometric and socioeconomic factors. It is a cross-sectional study conducted in 2010. on systematic sample of 900 subjects between 20... | 25,144,985 | [
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Surgical treatment of prolactinomas--our experience. | The dilemma of whether to apply surgical or drug treatment to prolactinomas has been ongoing for the past 30 years. The aim of this study is to compare the early postoperative values of prolactin (PRL) in two groups of patients with prolactinomas: those who underwent primary surgical-treatment, and those who underwent ... | 25,144,990 | [
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A study on utilization of oral contraceptives in the City of Zagreb (2008-2010). | Main aim of this study is to quantify and analyze the utilization and utilization trends of oral hormonal contraceptives in the City of Zagreb, 2008-2010, and to propose potential interventions, if necessary. Data gathered from Zagreb pharmacies were assessed by Anatomical Therapeutic Chemical Classification of drugs a... | 25,144,993 | [
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Respiratory distress syndrome in newborns of gestational age of over 32 weeks. | Albeit the aetiology of the respiratory distress syndrome (RDS) is well known, the paper shall demonstrate that the causes of RDS changed over the years 2006 and 2010. This retrospective study comprises analysis of the data collected from 60 newborns of over 32 weeks gestation with RDS in the Neonatal Intensive Care Un... | 25,144,999 | [
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A study on the quality of outpatient prescription of psychopharmaceuticals in the City of Zagreb 2006-2009. | The lack of Croatian studies which could determine the justifiability of excessive psychopharmaceutical utilization was an encouragement to conduct this research. Furthermore, regarding the conduction of this study, it would be possible to determine whether the trend of drug utilization has increased, decreased or perh... | 25,145,013 | [
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Skeletal remains from late Roman period: "as old as Diocletian's Palace". | In 2000, human skeletal remains were discovered in Split (Croatia). As archaeologists confirmed, it was an ancient skeleton accompanied by ceramics and bracelet characteristic for late Roman period whose possible violent death was excluded. The bone sample was radiocarbon dated by AMS to 1750 years. DNA was successfull... | 25,145,017 | [
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Human papillomavirus-related diseases of the female lower genital tract: oncogenic aspects and molecular interaction. | The causal role of human papillomavirus (HPV) in all cancers of the uterine cervix has been firmly established biologically and epidemiologically. Most cancers of both the vulva and the vagina are also induced by HPV. Papillomaviruses are perfectly adapted to their natural host tissue, the differentiating epithelial ce... | 25,145,023 | [
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Personal exposure to mixtures of volatile organic compounds: modeling and further analysis of the RIOPA data. | Emission sources of volatile organic compounds (VOCs*) are numerous and widespread in both indoor and outdoor environments. Concentrations of VOCs indoors typically exceed outdoor levels, and most people spend nearly 90% of their time indoors. Thus, indoor sources generally contribute the majority of VOC exposures for ... | 25,145,040 | [
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An unusual presentation of Salmonella typhi bacteriuria in a 10 year old girl from North India. | Enteric fever caused mainly by Salmonella typhi (S. typhi), has a high incidence in India. We report a case of enteric fever in a ten year old patient presenting with clinical history of less than one week. Although blood culture, the most important diagnostic modality in early stage of enteric fever was sterile, S. ty... | 25,145,066 | [
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Determination of pesticide residues in tea by gas chromatography/triple quadrupole mass spectrometry with solid-phase extraction. | An analytical method was developed for determination of multipesticide residues, including organophosphorus, organohalogen, pyrethroid, and organonitrogen, in tea at trace levels by GC coupled with triple quadrupole mass chromatography (QqQ-MS/MS). Scan time was selected in order to optimize QqQ-MS/MS conditions. The k... | 25,145,129 | [
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0.4622147,
0.3679012,
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0.03355422,
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-0.... |
Determination of penicillin G in milk samples using its effect on cloud point extraction of triiodide ion. | A cloud point extraction (CPE) method for determination of trace amounts of penicillin G by spectrophotometry based on its effect on the triiodide ion (I3(-)) has been developed. Penicillin G is converted to the corresponding penicilloic acid by carrying out hydrolysis with sodium hydroxide solution, and treatment with... | 25,145,162 | [
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... |
Storage-based denitrification with municipal wastewater: influence of the denitrification stage duration. | Microbial polyhydroxyalkenoates (PHAs) degradation is the rate limiting step for denitrification which is based on microbial carbon storage. The influence ofdenitrification stage duration (3, 2 and 1.5 h) on PHA degradation kinetics and denitrification efficiency during PHA-based denitrification ofmunicipal wastewater ... | 25,145,169 | [
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Comparison of harvesting methods for microalgae Chlorella sp. and its potential use as a biodiesel feedstock. | Three methods for harvesting Chlorella sp. biomass were analysed in this paper--centrifugation, membrane microfiltration and coagulation: there was no significant difference between the total amount of biomass obtained by centrifugation and membrane microfiltration, i.e., 0.1174 +/- 0.0308 and 0.1145 +/- 0.0268 g, resp... | 25,145,177 | [
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Recovery of struvite via coagulation and flocculation using natural compounds. | One of the major setbacks of struvite recovery processes is the difficulty in harvesting struvite crystals. This study evaluates the use of different coagulants to improve precipitation of struvite (MgNH4PO4.6H20) crystals. Chitosan and poly(diallyldimethyl ammonium chloride) (Poly-DADMAC) as a coagulant-flocculent and... | 25,145,182 | [
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... |
Adsorption of hydrogen sulphide from aqueous solutions using modified nano/micro fibrillated cellulose. | In the present study, microfibrillated cellulose (MFC) was modified by aminopropyltriethoxysilane (APS), hydroxy-carbonated apatite (HAP), or epoxy in order to produce novel nanostructured adsorbents for the removal of hydrogen sulphide (H2S) from the aqueous solutions. Structural properties of the modified MFC materia... | 25,145,187 | [
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0.24... |
Ultrasound-assisted surfactant-enhanced emulsification microextraction for the determination of Cd and Ni in tea and water samples. | A microextraction method based on ultrasound-assisted surfactant-enhanced emulsification using solidification of a floating organic droplet (UASEME-SFO) was evaluated for simultaneous determination of Cd and Ni in water and tea samples followed by flame atomic absorption spectrometry. In the UASEME-SFO technique, Trito... | 25,145,194 | [
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Effects of ageing on elution behaviour of nitrogenous compounds in disposed wastes from landfill sites. | Comparative studies of elution and cation exchange capacity (CEC) tests were applied to aged and fresh municipal and industrial solid wastes to examine the effects of ageing on the long-term elution behaviour of nitrogen on leachate in municipal and industrial solid waste landfill sites. Nitrogen in the leachate gradua... | 25,145,199 | [
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Comparative removal of commercial diclofenac sodium by electro-oxidation on platinum anode and combined electro-oxidation and electrocoagulation on stainless steel anode. | Aqueous solution of diclofenac sodium (DCFNa) from commercial analgesic pill was electro-oxidized on platinum and stainless steel (SS) anodes. On platinum anode, 66% degradation of the parent drug was achieved at pH 4.5 with a corresponding COD reduction of 49% for a specific charge of 4200 Coulombs/L. Degradation and ... | 25,145,203 | [
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Thermophilic co-digestion feasibility of distillers grains and swine manure: effect of C/N ratio and organic loading rate during high solid anaerobic digestion (HSAD). | Anaerobic co-digestion of high solids containing distillers grains and swine manure (total solids, 27 +/- 2% and 18 +/- 2%, respectively) was evaluated in this study to assess the effect of C/N ratio and organic loading rate (OLR). Feed mixture was balanced to achieve a C/N ratio of 30/1 by mixing distillers grains and... | 25,145,212 | [
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Impacts of tilling and covering treatments on the biosolids solar drying conversion from class B to class A. | The objective of this study was to evaluate the effects of tillage and cover treatments of solar drying on the conversion of class B treated sewage sludge to a class A product. The experiments were performed over two years at Green Valley, Arizona in steel-constructed sand-filled drying beds of 1.0 m (width) x 3.0 m (l... | 25,145,218 | [
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... |
High-speed imaging use to predict spray retention on barley leaves. | Measuring spray retention by plant leaves was the aim of many experiments in plant protection researches. Different methods have been used to measure spray proportion retained on vegetative surfaces, such as chemical methods using dyes and other methods using image analysis. We conducted Laboratory studies in order to ... | 25,145,223 | [
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Secondary metabolites: applications on cultural heritage. | Biological sciences and related bio-technology play a very important role in research projects concerning protection and preservation of cultural heritage for future generations. In this work secondary metabolites of Burkholderia gladioli pv. agaricicola (Bga) ICMP 11096 strain and crude extract of glycoalkaloids from ... | 25,145,230 | [
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Vegephy: impact of vegetable oils used as extemporaneous additives on pesticide residues and their crop protection potential. | Within the framework of the VEGEPHY project set up to assess the effect of refined oils used as extemporaneous additives, both alone and in combination with oligosaccharides (guar, xanthan and carboxymethyl cellulose), on the quality of plant protection treatments for wheat, a study was conducted on the effect of combi... | 25,145,232 | [
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Essential oil compounds as stress reducing agents in rats. | Essential oil compounds were studied to demonstrate their potential as stress reducing agents against rats. Rats were intraperitoneal administered with Linalool, Cineole and Thymol, respectively. Anxiety-related behaviors were determined by open field test and elevated plus maze test. Thymol reduced anxiety-related beh... | 25,145,237 | [
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Effect of eucalyptus wood vinegar on rubberwood infestation by Asian subterranean termite, Coptotermes gestroi Isoptera: Rhinotermitidae). | Wood degradation caused by fungi, termites, and insects, is a major problem for the rubberwood industry. The potential of wood vinegar as rubberwood preservative was studied. The infestation rates of Coptotermes gestroi (Wasmann) (Isoptera: Rhinotermitidae) on rubberwood samples treated with 25%, 50% and 100% eucalyptu... | 25,145,252 | [
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Toxicity of cypermethrin on the neotropical lacewing Chrysoperla externa (Neuroptera: Chrysopidae). | The generalist predator Chrysoperla externa (Neuroptera: Chrysopidae) is distributed in the Neotropical Region and presents a strong potential as a biological control agent due to its easily rearing, high voracity and tolerance to several pesticides. This species feeds on relevant pests such as aphids, whiteflies, trip... | 25,145,256 | [
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0.09480... |
Preliminary results on the ability of pentatomidae to transfer fire blight Erwinia amylovora under controlled conditions. | With their piercing-sucking mouthparts stink bugs (Heteroptera: Pentatomidae), a major pest in especially organic orchards, create wounds in fruit of pear trees. As Erwinia amylovora (Burrill, Winslow et al.), a wide spread bacterial disease affecting many rosaceous plants including pome fruit trees and hawthorn, enter... | 25,145,257 | [
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Pharmacological inhibition of coronary restenosis: systemic and local approaches. | Percutaneous coronary intervention (PCI) with stent implantation has revolutionized the treatment of obstructive coronary artery disease. However, the main limitation of this therapy is stent failure, which is usually caused by in-stent restenosis. The aim of this article is to critically review the literature on the p... | 25,145,263 | [
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Urinary excretion of arsenic following rice consumption. | Patterns of arsenic excretion were followed in a cohort (n = 6) eating a defined rice diet, 300 g per day d.wt. where arsenic speciation was characterized in cooked rice, following a period of abstinence from rice, and other high arsenic containing foods. A control group who did not consume rice were also monitored. Th... | 25,145,278 | [
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Hydrogen-bond-directed-linking solving transparence-efficiency tradeoff in nonlinear optical molecule. | It is well known that settling transparency-efficiency tradeoff is important to design nonlinear optical (NLO) materials. In this work, we constructed one-dimensional polymeric cyanoacetylene (NCCCH)n by hydrogen-bond-directed-linking to understand this tradeoff from molecular level. Results show that the first hyperpo... | 25,145,287 | [
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Comparison of effectiveness and cost between perventricular device occlusion and minimally invasive surgical repair for perimembranous ventricular septal defect. | Perventricular device occlusion and minimally invasive surgical repair for perimembranous ventricular septal defect (pmVSD) are two typical methods to reduce the invasiveness of the conventional operation through median sternotomy. However, few comparative studies have been made between them in terms of effectiveness a... | 25,145,293 | [
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Concise stereoselective synthesis of oxaspirocycles with 1-tosyl-1,2,3-triazoles: application to the total syntheses of (±)-Tuberostemospiroline and (±)-stemona-lactam R. | A 4-substituted-1-tosyl-1,2,3-triazole-based stereoselective synthesis of structurally diverse oxaspirocycles is reported. The synthesis involves Rh-catalyzed loss of nitrogen from 4-substituted-1-tosyl-1,2,3-triazoles, Grignard reaction, and a ring-closing metathesis reaction as key steps. By employing readily availab... | 25,145,296 | [
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Coming to work sick: a survey of hospital doctors in New Zealand. | To estimate the rate of sickness presenteeism in hospital doctors in a New Zealand tertiary hospital and to also identify reasons for why doctors continue to work whilst sick. An anonymous online survey about sickness presenteeism for all hospital doctors at one tertiary care hospital in New Zealand The response rate f... | 25,145,303 | [
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Progress of successful New Zealand Registration Examination (NZREX Clinical) candidates during their first year of supervised clinical practice in New Zealand. | To determine the frequency and nature of clinical difficulties faced in the first year of supervised clinical practice by international medical graduates (IMGs) who have successfully passed NZREX Clinical in order to be able to practise in New Zealand. All doctors who successfully passed NZREX Clinical and who register... | 25,145,304 | [
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-... |
A review of the Christchurch Hospital Breast Cancer Service in 2012: meeting the new Tumour Standards. | To determine whether patients diagnosed with breast cancer in 2012 received timely access to services at Christchurch Hospital when audited against Ministry of Health Tumour Standards of Service Provision (TS) (2013) and the Faster Cancer Treatment (FCT) indicators, and to discover factors which impeded patient pathway... | 25,145,307 | [
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Modeling stroke in mice: permanent coagulation of the distal middle cerebral artery. | Stroke is the third most common cause of death and a main cause of acquired adult disability in developed countries. Only very limited therapeutical options are available for a small proportion of stroke patients in the acute phase. Current research is intensively searching for novel therapeutic strategies and is incre... | 25,145,316 | [
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RNA isolation from mouse pancreas: a ribonuclease-rich tissue. | Isolation of high-quality RNA from ribonuclease-rich tissue such as mouse pancreas presents a challenge. As a primary function of the pancreas is to aid in digestion, mouse pancreas may contain as much a 75 mg of ribonuclease. We report modifications of standard phenol/guanidine thiocyanate lysis reagent protocols to i... | 25,145,327 | [
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NUP98/NSD1 and FLT3/ITD coexpression is more prevalent in younger AML patients and leads to induction failure: a COG and SWOG report. | NUP98/NSD1 has recently been reported in association with poor outcome in acute myeloid leukemia (AML). Previous studies also observed a high overlap between NUP98/NSD1 and FLT3/ITD, raising the question as to whether the reported poor outcome is due to NUP98/NSD1 or caused by the co-occurrence of these 2 genetic lesio... | 25,145,343 | [
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Grail controls Th2 cell development by targeting STAT6 for degradation. | T helper (Th)-2 cells are the major players in allergic asthma; however, the mechanisms that control Th2-mediated inflammation are poorly understood. Here we find that enhanced expression of Grail, an E3 ubiquitin ligase, in Th2 cells depends on interleukin (IL)-4-signalling components, signal transducer and activator ... | 25,145,352 | [
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Backseat drivers: Regulation of dynein motility. | Control of the activity of the microtubule motor cytoplasmic dynein 1 is essential for its function in intracellular transport. A recent paper by McKenney et al. published in Science shows that activation of processive dynein motility requires the formation of cargo adaptor-dynein-dynactin complexes. | 25,145,357 | [
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Using drawing tests to explore the multidimensional psychological aspects of children with cancer. | In seeking to understand how life-threatening illness affects children psychologically, projective testing may be beneficial, particularly when attempting to identify psychological problems in younger adolescents. The advantages of projective testing are that it does not depend on patients' verbal ability and is not in... | 25,145,380 | [
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Long noncoding RNAs in liver cancer: what we know in 2014. | Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer with an estimated over half a million new cases diagnosed annually. Due to the difficulty in early diagnosis and lack of effective treatment options, HCC is currently ranked as the second highest neoplastic-related mortality in the world, wi... | 25,145,388 | [
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The role of general practitioners in the pre hospital setting, as experienced by emergency medicine technicians: a qualitative study. | Together with the ambulances staffed with emergency medical technicians (EMTs), general practitioners (GPs) on call are the primary resources for handling emergencies outside hospitals in Norway. The benefit of the GP accompanying the ambulance to pre-hospital calls is a matter of controversy in Norway. The purpose of ... | 25,145,390 | [
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Distinct subclades of Aux/IAA genes are direct targets of ARF5/MP transcriptional regulation. | The regulatory interactions between AUXIN RESPONSE FACTORS (ARFs) and Aux/IAA repressors play a central role in auxin signal transduction. Yet, the systems properties of this regulatory network are not well established. We generated a steroid-inducible ARF5/MONOPTEROS (MP) transgenic background to survey the involvemen... | 25,145,395 | [
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Cold exposure inhibits hypothalamic Kiss-1 gene expression, serum leptin concentration, and delays reproductive development in male Brandt's vole (Lasiopodomys brandtii). | Cold commonly affects growth and reproductive development in small mammals. Here, we test the hypothesis that low ambient temperature will affect growth and puberty onset, associated with altered hypothalamic Kiss-1 gene expression and serum leptin concentration in wild rodents. Male Brandt's voles (Lasiopodomys brandt... | 25,145,442 | [
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Liquid crystal size selection of large-size graphene oxide for size-dependent N-doping and oxygen reduction catalysis. | Graphene oxide (GO) is aqueous-dispersible oxygenated graphene, which shows colloidal discotic liquid crystallinity. Many properties of GO-based materials, including electrical conductivity and mechanical properties, are limited by the small flake size of GO. Unfortunately, typical sonochemical exfoliation of GO from g... | 25,145,457 | [
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A multicenter phase I dose escalation trial to evaluate safety and tolerability of intra-arterial temozolomide for patients with advanced extremity melanoma using normothermic isolated limb infusion. | L-phenylalanine mustard (LPAM) has been the standard for use in regional chemotherapy (RC) for unresectable in-transit melanoma. Preclinical data demonstrated that regional temozolomide (TMZ) may be more effective. Patients with AJCC Stage IIIB or IIIC extremity melanoma who failed previous LPAM-based RC were treated w... | 25,145,500 | [
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Genome-wide association study of survival in early-stage non-small cell lung cancer. | Lung cancer, especially non-small cell lung cancer (NSCLC), is the leading cause of cancer-related deaths all over the world. Studies have indicated that molecular biomarkers, including genetic variants, may provide additional values for the targeted treatments and clinical outcomes of NSCLC patients. To better underst... | 25,145,502 | [
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Clinical significance of thrombocytosis before preoperative chemoradiotherapy in rectal cancer: predicting pathologic tumor response and oncologic outcome. | Thrombocytosis is considered an adverse prognostic factor in various malignancies. However, the clinical significance of thrombocytosis in rectal cancer patients is unknown. We investigated the predictive value of thrombocytosis for pathologic tumor response to preoperative chemoradiotherapy (CRT) and oncologic outcome... | 25,145,505 | [
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Mesenchymal stem cells, not conditioned medium, contribute to kidney repair after ischemia-reperfusion injury. | Studies have shown that stem cells exert their therapeutic effects on acute kidney injury (AKI) through paracrine/endocrine actions. If the protective effect is mediated in an endocrine manner, the injection of the factors that these cells secrete could be effective, but the effect of conditioned medium (CM) remains co... | 25,145,540 | [
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Improved sensitivity of the nano ultra-high performance liquid chromatography-tandem mass spectrometric analysis of low-concentrated neuropeptides by reducing aspecific adsorption and optimizing the injection solvent. | Obtaining maximal sensitivity of nano UHPLC-MS/MS methods is primordial to quantify picomolar concentrations of neuropeptides in microdialysis samples. Since aspecific adsorption of peptides to Eppendorf tubes, pipette tips and UHPLC vials is detrimental for method sensitivity, a strategy is presented to reduce adsorpt... | 25,145,562 | [
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Occurrence of turbulent flow conditions in supercritical fluid chromatography. | Having similar densities as liquids but with viscosities up to 20 times lower (higher diffusion coefficients), supercritical CO2 is the ideal (co-)solvent for fast and/or highly efficient separations without mass-transfer limitations or excessive column pressure drops. Whereas in liquid chromatography the flow remains ... | 25,145,564 | [
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Perceived cancer risk and risk attributions among African-American residents of a low-income, predominantly African-American neighborhood. | In some national surveys, African-Americans have had lower scores on perceived cancer risk items than whites. Our goals were to confirm low perceptions of cancer risk in an African-American community sample and explore participants' attributions for their perceived cancer risk. Data were from three cross-sectional surv... | 25,145,570 | [
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Multiplexed electrochemical detection of trypsin and chymotrypsin based on distinguishable signal nanoprobes. | In this work, we developed a novel multisignal output for simultaneous detection of multiple proteases by using nanoprobes labeled with distinguishable electrochemical probes. First, biotinylated peptide1 (S1) and biotinylated peptide2 (S2) were associated with biotinylated DNA1 and DNA2 via biotin-streptavidin interac... | 25,145,572 | [
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Development of a microsimulation of melanoma mortality for evaluating the effectiveness of population-based skin cancer screening. | A nationwide skin cancer screening (SCS) was implemented in Germany in 2008. It aims at improving early detection of melanoma in order to reduce melanoma mortality. While the idea of early detection is compelling, demonstrating the effectiveness of melanoma screening is crucial. Since it is not feasible to conduct epid... | 25,145,574 | [
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Salivary cortisol and α-amylase responses to repeated bouts of downhill running. | To determine the hypothalamic-pituitary-adrenal (HPA) axis and sympathoadrenal (SA) system response to repeated bouts of downhill running. Eleven active but untrained males (age: 19.7 ± 0.4 y; VO2peak 47.8 ± 3.6 ml/kg/min) performed two 60 min bouts of downhill running (-13.5% gradient), separated by 14 days, at a spee... | 25,145,588 | [
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The benzylperoxyl radical as a source of hydroxyl and phenyl radicals. | The benzyl radical (1) is a key intermediate in the combustion and tropospheric oxidation of toluene. Because of its relevance, the reaction of 1 with molecular oxygen was investigated by matrix-isolation IR and EPR spectroscopy as well as computational methods. The primary reaction product of 1 and O2 is the benzylper... | 25,145,605 | [
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Vagus nerve stimulation magnet activation for seizures: a critical review. | Some patients receiving VNS Therapy report benefit from manually activating the generator with a handheld magnet at the time of a seizure. A review of 20 studies comprising 859 subjects identified patients who reported on-demand magnet mode stimulation to be beneficial. Benefit was reported in a weighted average of 45%... | 25,145,652 | [
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Systems level metabolic phenotype of methotrexate administration in the context of non-alcoholic steatohepatitis in the rat. | Adverse drug reactions (ADRs) represent a significant clinical challenge with respect to patient morbidity and mortality. We investigated the hepatotoxicity and systems level metabolic phenotype of methotrexate (MTX) in the context of a prevalent liver disease; non-alcoholic steatohepatitis (NASH). A nuclear magnetic r... | 25,145,655 | [
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Stage-dependent C-reflex, pain-like behavior and opioid analgesia during the induction of chronic arthritis in rats. | Chronic arthritis (CA) is a common clinical entity associated with persistent pain and limited response to opioid analgesic therapy. However, it is unknown whether these features of CA change depending on its stage of evolution. To address this, in a well-established animal model of CA we studied the time course of ele... | 25,145,673 | [
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Hyperammonia induces specific liver injury through an intrinsic Ca2+-independent apoptosis pathway. | Numerous pathological processes that affect liver function in patients with liver failure have been identified. Among them, hyperammonia is one of the most common phenomena.The purpose of this study was to determine whether hyperammonia could induced specific liver injury. Hyperammonemic cells were established using NH... | 25,145,683 | [
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Addressing adolescent pregnancy with legislation. | Adolescent pregnancy is a concern among many women's health practitioners. While it is practical and appropriate to work to prevent adolescent pregnancy by educating adolescents in health care clinics, schools and adolescent-friendly community-based organizations, suggesting and supporting legislative efforts to reduce... | 25,145,716 | [
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Overview of latest evidence on uterine fibroids. | Uterine fibroids are the most common type of benign gynecologic mass, and are present in up to 80 percent of women. Research exploring risk factors for fibroids presents conflicting or inconclusive findings. Symptoms for up to 50 percent of women experiencing fibroids include heavy menstrual bleeding, pelvic pressure o... | 25,145,720 | [
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... |
A quality improvement project focused on women's perceptions of skin-to-skin contact after cesarean birth. | A quality improvement (QI) project was designed to identify women's perceptions of the benefits of skin-to-skin contact with newborns immediately following cesarean birth. Women reported positive experiences associated with skin-to-skin contact with their newborns. A major theme that emerged was that women who had cesa... | 25,145,718 | [
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0.0001137683,
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-0.370614,
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0.1957308,
-0.2058291,
0.182365,
-0.0357372,
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-0.5330556,
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0.03918286,
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0.008957085,
0.1004972,
0.006242... |
Population health outcome models in suicide prevention policy. | Suicide is a leading cause of death in the U.S. and results in immense suffering and significant cost. Effective suicide prevention interventions could reduce this burden, but policy makers need estimates of health outcomes achieved by alternative interventions to focus implementation efforts. To illustrate the utility... | 25,145,731 | [
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A review of evidence-based follow-up care for suicide prevention: where do we go from here? | Follow-up services are an important component of a comprehensive, national strategy for suicide prevention. Increasing our knowledge of effective follow-up care has been identified as an Aspirational Goal by The National Action Alliance for Suicide Prevention's Research Prioritization Task Force. Several recent compreh... | 25,145,741 | [
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Adsorption-geometry induced transformation of self-assembled nanostructures of an aldehyde molecule on Cu(110). | From an interplay of high-resolution STM imaging/manipulation and DFT calculations, we have revealed that different self-assembled nanostructures of BA molecules on Cu(110) are attributable to specific molecular adsorption geometries, and thus the corresponding intermolecular hydrogen bonding patterns. The STM manipula... | 25,145,767 | [
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Decreasing hepatitis B viral load is associated with a risk of significant liver fibrosis in hepatitis B e antigen positive chronic hepatitis B. | Alanine aminotransferase (ALT), hepatitis B virus (HBV) DNA levels and age are used commonly to assess liver histology in chronic hepatitis B. Increasing levels of HBV DNA are associated with the increasing prevalence of significant fibrosis in HBeAg-negative patients. It is unclear whether these data can be applied to... | 25,145,769 | [
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Adiponectin predicts MMP-2 activity independently of obesity. | Matrix metalloproteinases (MMPs), especially MMP-2 and MMP-9, have been identified in atherosclerotic plaques and have been directly associated with plaque remodelling and vulnerability. Cardiovascular disease (CVD) is related to insulin resistance (IR) and obesity, characterized by changes in plasma levels of inflamma... | 25,145,771 | [
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Promotion of survival and differentiation of neural stem cells with fibrin and growth factor cocktails after severe spinal cord injury. | Neural stem cells (NSCs) can self-renew and differentiate into neurons and glia. Transplanted NSCs can replace lost neurons and glia after spinal cord injury (SCI), and can form functional relays to re-connect spinal cord segments above and below a lesion. Previous studies grafting neural stem cells have been limited b... | 25,145,787 | [
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Investigating the physiological roles of low-efficiency D-mannonate and D-gluconate dehydratases in the enolase superfamily: pathways for the catabolism of L-gulonate and L-idonate. | The sequence/function space in the D-mannonate dehydratase subgroup (ManD) of the enolase superfamily was investigated to determine how enzymatic function diverges as sequence identity decreases [Wichelecki, D. J., et al. (2014) Biochemistry 53, 2722-2731]. That study revealed that members of the ManD subgroup vary in ... | 25,145,794 | [
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Bidirectional citation searching to completion: an exploration of literature searching methods. | Literature reviews underpin the majority of research projects in the health sciences, and yet relatively little analysis has been published as to the most appropriate method to identify relevant literature, outside of specialist information journals. The method of applying keyword search queries to bibliographic databa... | 25,145,803 | [
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The effects of epistaxis on health-related quality of life in patients with hereditary hemorrhagic telangiectasia. | Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disease mainly characterized by epistaxis in more than 96% of patients. Recently, a validated questionnaire known as the HHT Epistaxis Severity Score (ESS) was developed. However, little is known about the relationship between epistaxis and quality of... | 25,145,809 | [
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0.009234059,
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Minimally invasive esophagectomy for dysplastic Barrett's esophagus. | A substantial portion of patients diagnosed preoperatively with high grade dysplasia (HGD) alone will have occult esophageal adenocarcinoma on analysis of the surgical specimen. Therefore, because of an increased risk of disease progression and malignancy, patients with HGD should be referred for esophagectomy promptly... | 25,145,822 | [
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Is clinical performance adversely affected by wearing gloves during paediatric peripheral intravenous cannulation? | To investigate if wearing protective gloves during paediatric intravenous cannulation affects performance of the procedure. This was a prospective observational study. Peripheral intravenous cannulation (PIVC) performed within the Paediatric ED was observed and recorded over a 12 month period. Data were compared betwee... | 25,145,829 | [
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Kinetic resolution of 1,1'-biaryl-2,2'-diols and amino alcohols through NHC-catalyzed atroposelective acylation. | We present here a highly efficient NHC-catalyzed kinetic resolution of a wide range of 1,1'-biaryl-2,2'-diols and amino alcohols to provide them in uniformly ≥99% ee. This represents the first highly enantioselective catalytic acylation of axially chiral alcohols. The aldehyde backbone that is incorporated into the chi... | 25,145,856 | [
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Small molecule activation by POC(sp3)OP-nickel complexes. | This contribution describes the reactivities of CO2 , CO, O2 , and ArNC with the pincer-type complexes [(κ(P) ,κ(C) ,κ(P') -POC sp 3OP)NiX] (POC sp 3OP=(R2 POCH2 )2 CH; R=iPr; X=OSiMe3 , NArH; Ar=2,6-iPr2 C6 H3 ). Reaction of the amido derivative with CO2 and CO leads to a simple insertion into the NiN bond to give st... | 25,145,857 | [
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Expression of toll-like receptors and co-stimulatory molecules in lymphoid tissue during experimental infection of beef calves with bovine viral diarrhea virus of low and high virulence. | The objective of this study was to compare the mRNA expression of Toll-like receptors (TLR3 and TLR7), and costimulatory molecules involved in activation of lymphocytes and antigen presenting cells (CD80, CD86, CD28, and CD40L) after experimental infection of beef calves with low or high virulence noncytopathic (ncp) b... | 25,145,871 | [
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Masked smoothing using separable kernels for CT perfusion images. | CT perfusion images have a high contrast ratio between voxels representing different anatomy, such as tissue or vessels, which makes image segmentation of tissue and vascular regions relatively easy. However, grey and white matter tissue regions have relatively low values and can suffer from poor signal to noise ratios... | 25,145,879 | [
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0.140991,
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High-load strength training improves outcome in patients with plantar fasciitis: A randomized controlled trial with 12-month follow-up. | The aim of this study was to investigate the effectiveness of shoe inserts and plantar fascia-specific stretching vs shoe inserts and high-load strength training in patients with plantar fasciitis. Forty-eight patients with ultrasonography-verified plantar fasciitis were randomized to shoe inserts and daily plantar-spe... | 25,145,882 | [
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Intravascular lymphoma: an unusual cause of rapid cognitive decline and the role of brain biopsy. | Intravascular lymphoma (IVL) is a rare extra nodal variant of non Hodgkin's lymphoma characterised by neoplastic lymphoid cells growing inside the lumina of medium and small vessels. IVL limited to the central nervous system (CNS) is an extremely rare condition as IVL is usually found with systemic lesions. Most cases ... | 25,145,897 | [
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Paragangliomas: presentation and management by radiotherapy at the Prince of Wales Hospital. | Paragangliomas are commonly treated with surgery, while radiotherapy is reserved for those that are inoperable or have relapsed. However, this retrospective study aims to determine whether radiotherapy is a viable initial treatment for paragangliomas. Of 73 tumours researched, 44 were diagnosed and treated from January... | 25,145,920 | [
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0.1336224,
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0.44503,
0.03455701,
0.34... |
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