title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Pediatric eosinophilic esophagitis is associated with changes in esophageal microRNAs. | The incidence of eosinophilic esophagitis (EoE) has increased in the past several years, yet our understanding of its pathogenesis remains limited. To test the hypothesis that microRNAs (miRNAs) are altered in children with EoE, miRNAs were profiled in esophageal mucosa biopsies obtained from patients with active disea... | 25,147,232 | [
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Transforming growth factor-β2 and endotoxin interact to regulate homeostasis via interleukin-8 levels in the immature intestine. | A balance between pro- and anti-inflammatory signals from milk and microbiota controls intestinal homeostasis just after birth, and an optimal balance is particularly important for preterm neonates that are sensitive to necrotizing enterocolitis (NEC). We suggest that the intestinal cytokine IL-8 plays an important rol... | 25,147,235 | [
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The utility of genotypic tropism testing in clinical practice. | A review of a large number of HIV-1 tropism test requests (n = 1148) performed at a London tertiary referral centre was carried out. The aim was to establish whether these were being performed in line with recommendations from published guidelines and whether this represented the most cost-effective use of these tests ... | 25,147,237 | [
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Thermoregulatory strategy may shape immune investment in Drosophila melanogaster. | As temperatures change, insects alter the amount of melanin in their cuticle to improve thermoregulation. However, melanin is also central to insect immunity, suggesting that thermoregulatory strategy may indirectly impact immune defense by altering the abundance of melanin pathway components (a hypothesis we refer to ... | 25,147,243 | [
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N-Acetylcysteine Ameliorates Experimental Autoimmune Myocarditis in Rats via Nitric Oxide. | Oxidative stress may play an important role in the development of myocarditis. We investigated the effects of N-acetylcysteine (NAC), a potent antioxidant, on experimental autoimmune myocarditis (EAM) in rats. A rat model of porcine myosin-induced EAM was used. After the immunization with myosin, NAC (20 mg/kg/d) or sa... | 25,147,347 | [
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Flaws in evaluations of social programs: illustrations from randomized controlled trials. | This article describes eight flaws that occur in impact evaluations. The eight flaws are grouped into four categories on how they affect impact estimates: statistical imprecision; biases; failure of impact estimates to measure effects of the planned treatment; and flaws that result from weakening an evaluation design. ... | 25,147,355 | [
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PyBamView: a browser-based application for viewing short read alignments. | Current sequence alignment browsers allow visualization of large and complex next-generation sequencing datasets. However, most of these tools provide inadequate display of insertions and can be cumbersome to use on large datasets. I implemented PyBamView, a lightweight Web application for visualizing short read alignm... | 25,147,359 | [
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Bullying in the clinical training of pharmacy students. | To determine whether bullying is a significant factor in the clinical training of pharmacy students. The literature as well as the Accreditation Council for Pharmacy Education (ACPE) Standards and American Association of Colleges of Pharmacy (AACP) surveys were reviewed for mention and/or measurement of bullying behavi... | 25,147,389 | [
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Implementation of an integrated longitudinal curricular activity for graduating pharmacy students. | To evaluate whether a novel integrated longitudinal curricular activity to prepare graduating doctor of pharmacy (PharmD) students for 2 comprehensive examinations was successful, and to assess whether it engaged other pharmacy students in curricular discussion and learning. Thirty-eight of 91graduating third-year (P3)... | 25,147,396 | [
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Advanced screencasting with embedded assessments in pathophysiology and therapeutics course modules. | To implement and assess the effectiveness of a hybrid learning model using advanced screencasting with embedded assessments in pathophysiology and therapeutics modules. Two pathophysiology and therapeutics course modules on viral hepatitis and the clinical pharmacokinetics of aminoglycosides were chosen for study. The ... | 25,147,400 | [
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Two Decades of Stability and Change in Age at First Union Formation. | The landscape of union formation has been shifting; Americans are now marrying at the highest ages on record and the majority of young adults have cohabited. Yet little attention has been paid to the timing of cohabitation relative to marriage. Using the National Survey of Families and Households and 4 cycles of the Na... | 25,147,410 | [
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Asymmetric oxidative dearomatizations promoted by hypervalent iodine(III) reagents: an opportunity for rational catalyst design? | The use of and λ<sup3</sup- and λ<sup5</sup-iodanes in the oxidative dearomatization of phenols is a well-established and general procedure for the construction of cyclohexadienone structures. However, their use in asymmetric dearomatization reactions is quite underdeveloped and, despite work by several research groups... | 25,147,412 | [
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The surface density gradient of grafted poly (ethylene glycol): preparation, characterization and protein adsorption. | A surface density gradient of grafted poly (ethylene glycol) (PEG) chains was prepared using two-phase silanization of a flat silica surface. The first step was to create the surface density gradient of isocyanatopropyldimethylsilyl groups and to hydrolyze the isocyanato moiety into an amine. These surface amines were ... | 25,147,429 | [
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The effects of amphiregulin induced MMP-13 production in human osteoarthritis synovial fibroblast. | Osteoarthritis (OA) belongs to a group of degenerative diseases. Synovial inflammation, cartilage abrasion, and subchondral sclerosis are characteristics of OA. Researchers do not fully understand the exact etiology of OA. However, matrix metalloproteinases (MMPs), which are responsible for cartilage matrix degradation... | 25,147,440 | [
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Revision of the genus Hemisaprinus Kryzhanovskij, 1976 (Coleoptera, Histeridae, Saprininae). | The monophyletic genus Hemisaprinus Kryzhanovskij in Kryzhanovskij & Reichardt, 1976 is revised herein. All three species Hemisaprinus subvirescens (Ménétries, 1832), H. lutshniki (Reichardt, 1941) and H. cyprius (Dahlgren, 1981) are found to be correctly assigned to the genus and their monophyly is supported by th... | 25,147,473 | [
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A Randomised Controlled Trial Comparing the Impact of Yoga and Physical Education on the Emotional and Behavioural Functioning of Middle School Children. | Yoga programs geared for school children have become more widespread, but research regarding its impact on children is lacking. Several studies have reported positive outcomes, though there is a need for more randomised controlled trials. To determine the effects of yoga on children's emotional and behavioural function... | 25,147,479 | [
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Estimation of whole body fat from appendicular soft tissue from peripheral quantitative computed tomography in adolescent girls. | Assess the utility of peripheral quantitative computed tomography (pQCT) for estimating whole body fat in adolescent girls. Our sample included 458 girls (aged 10.7 ± 1.1y, mean BMI = 18.5 ± 3.3 kg/m<sup2</sup) who had DXA scans for whole body percent fat (DXA %Fat). Soft tissue analysis of pQCT scans provided thigh an... | 25,147,482 | [
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Learning Stimulus-Location Associations in 8- and 11-Month-Old Infants: Multimodal versus Unimodal Information. | Research on the influence of multimodal information on infants' learning is inconclusive. While one line of research finds that multimodal input has a negative effect on learning, another finds positive effects. The present study aims to shed some new light on this discussion by studying the influence of multimodal inf... | 25,147,483 | [
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Synthesis, spectral characterization, and biological evaluation of transition metal complexes of bidentate N, o donor schiff bases. | New series of three bidentate N, O donor type Schiff bases (L (1) )-(L (3) ) were prepared by using ethylene-1,2-diamine with 5-methyl furfural, 2-anisaldehyde, and 2-hydroxybenzaldehyde in an equimolar ratio. These ligands were further complexed with Co(II), Cu(II), Ni(II), and Zn(II) metals to produce their new metal... | 25,147,493 | [
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Oxytocin in the medial prefrontal cortex regulates maternal care, maternal aggression and anxiety during the postpartum period. | The neuropeptide oxytocin (OT) acts on a widespread network of brain regions to regulate numerous behavioral adaptations during the postpartum period including maternal care, maternal aggression, and anxiety. In the present study, we examined whether this network also includes the medial prefrontal cortex (mPFC). We fo... | 25,147,513 | [
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Cardiac magnetic resonance and computed tomography angiography for clinical imaging of stable coronary artery disease. Diagnostic classification and risk stratification. | Despite advances in the pharmacologic and interventional treatment of coronary artery disease (CAD), atherosclerosis remains the leading cause of death in Western societies. X-ray coronary angiography has been the modality of choice for diagnosing the presence and extent of CAD. However, this technique is invasive and ... | 25,147,526 | [
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The development of sensorimotor influences in the audiovisual speech domain: some critical questions. | Speech researchers have long been interested in how auditory and visual speech signals are integrated, and the recent work has revived interest in the role of speech production with respect to this process. Here, we discuss these issues from a developmental perspective. Because speech perception abilities typically out... | 25,147,528 | [
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Social values as arguments: similar is convincing. | Politicians, philosophers, and rhetors engage in co-value argumentation: appealing to one value in order to support another value (e.g., "equality leads to freedom"). Across four experiments in the United Kingdom and India, we found that the psychological relatedness of values affects the persuasiveness of the argument... | 25,147,529 | [
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The intimate relationship between human cytomegalovirus and the dendritic cell lineage. | Primary infection of healthy individuals with human cytomegalovirus (HCMV) is normally asymptomatic but results in the establishment of a lifelong infection of the host. One important cellular reservoir of HCMV latency is the CD34+ haematopoietic progenitor cells resident in the bone marrow. Viral gene expression is hi... | 25,147,545 | [
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Approaches to identify genetic variants that influence the risk for onset of fragile X-associated primary ovarian insufficiency (FXPOI): a preliminary study. | Fragile X-associated primary ovarian insufficiency (FXPOI) is due to an X-linked mutation that results from the expansion of a CGG repeat sequence located in the 5' untranslated region of the FMR1 gene (premutation, PM). About 20% of women who carry the PM have cessation of menses before age 40, a clinical condition kn... | 25,147,555 | [
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Plasma Interleukin-10: A Likely Predictive Marker for Hepatitis B Virus-Related Acute-on-Chronic Liver Failure. | The pathogenesis of HBV-related acute-on-chronic liver failure (HBV-ACLF) is mainly based on a heightened immune-inflammatory reaction; however, the intimate underlying mechanism remains unclear. The aim of the study was to explore potential key immune molecular targets that could serve as early predictive markers for ... | 25,147,572 | [
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Preceptor preferences for participating in electronic preceptor development. | New guidelines require preceptors to deliver approximately 30% of the doctor of pharmacy curricula. With preceptor's increasing responsibilities, colleges are faced with the task of training preceptors as educators. Identifying preceptor's training format preferences (i.e. electronic vs. live) should contribute to the ... | 25,147,592 | [
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Identification of novel phenyl butenonyl C-glycosides with ureidyl and sulfonamidyl moieties as antimalarial agents. | A new series of C-linked phenyl butenonyl glycosides bearing ureidyl(thioureidyl) and sulfonamidyl moieties in the phenyl rings were designed, synthesized, and evaluated for their in vitro antimalarial activities against Plasmodium falciparum 3D7 (CQ sensitive) and K1 (CQ resistant) strains. Among all the compounds scr... | 25,147,607 | [
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Fluorescent Probes for Subcellular Localization during Osteclast Formation. | Labeling of a small bioactive molecule with fluorescent probe has been becoming an essential tool in cell biology to reveal the subcellular distribution and the location of a molecular target. QOA-8a is a novel molecule with potent antiosteoporotic effect in vivo. To investigate the molecular mechanism of QOA-8a, novel... | 25,147,613 | [
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Discovery and structure-based optimization of adenain inhibitors. | The cysteine protease adenain is the essential protease of adenovirus and, as such, represents a promising target for the treatment of ocular and other adenoviral infections. Through a concise two-pronged hit discovery approach we identified tetrapeptide nitrile 1 and pyrimidine nitrile 2 as complementary starting poin... | 25,147,618 | [
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Cytotaxonomy of two species of genus Chrysolaena H. Robinson, 1988 (Vernonieae, Asteraceae) from Northeast Paraguay. | Chromosome counts and karyotypes of two species of Chrysolaena H. Robinson 1988 are presented in this paper. Mitotic analysis revealed that both taxa have x=10, a basic chromosome number considered characteristic of the genus. The chromosome number and the karyotype of Chrysolaena cristobaliana are reported for the fir... | 25,147,624 | [
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Chronic pain patients with possible co-morbid post-traumatic stress disorder admitted to multidisciplinary pain rehabilitation-a 1-year cohort study. | Although post-traumatic stress disorder (PTSD) is a common co-morbidity in chronic pain, little is known about the association between PTSD and pain in the context of chronic pain rehabilitation. The aim of the present study was two-fold: (1) to investigate the association of a possible PTSD diagnosis with symptoms of ... | 25,147,628 | [
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Antibody-mediated immunity induced by engineered Escherichia coli OMVs carrying heterologous antigens in their lumen. | Outer membrane vesicles (OMVs) from Gram-negative bacteria are gaining increasing attention as vaccine platform for their built-in adjuvanticity and for their potential use as carriers of heterologous antigens. These 2 properties offer the opportunity to make highly effective, easy to produce multi-valent vaccines. OMV... | 25,147,647 | [
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Severe falciparum malaria in iran: a very rare case from an endemic region. | Malaria is a protozoal disease, transmitted to humans by female Anopheles mosquito bite. Plasmodium falciparum, compared to other kinds of Plasmodium, causes more severe malaria and is associated with a higher mortality rate. Annually, one to three million deaths occur due to malaria, especially by P. falciparum. In th... | 25,147,660 | [
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Eradication of Pseudomonas aeruginosa Biofilms Using the Combination of n-butanolic Cyclamen coum Extract and Ciprofloxacin. | Biofilm formation is a major pathogenic factor in different bacteria such as Pseudomonas aeruginosa. A number of studies have reported that bacterial biofilms show different levels of antibiotic resistance. In order to re-sensitize the bacterial biofilms to antibiotics, biofilms should be dispersed. In this study, the ... | 25,147,668 | [
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Production and Screening of High Yield Avermectin B1b Mutant of Streptomyces avermitilis 41445 Through Mutagenesis. | Secondary metabolite production from wild strains is very low for economical purpose therefore certain strain improvement strategies are required to achieve hundred times greater yield of metabolites. Most important strain improvement techniques include physical and chemical mutagenesis. Broad spectrum mutagenesis thro... | 25,147,669 | [
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Evaluating the Efficacy of Achillea millefolium and Thymus vulgaris Extracts Against Newcastle Disease Virus in Ovo. | Nowadays natural products such as pure compounds and plant extract scan provide unlimited opportunities for new antiviral drugs. Newcastle disease virus (NDV) is one of the most important viral diseases in poultry industry. Vaccination could provide protection against NDV outbreaks, but it is not sufficient because inf... | 25,147,678 | [
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Characterization of Variations in PB2, NS1, M, Neuraminidase and Hemagglutinin of Influenza A (H3N2) Viruses in Iran. | In the influenza A viruses, neuraminidase (NA), hemagglutinin (HA), PB2, NS1 and M are responsible for the disease pathogenicity. The mechanism of pathogenicity differs among these viruses. Binding of host proteases by the viral NA, sequence of HA in the cleavage and receptor-binding sites, number of oligosaccharide si... | 25,147,684 | [
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The rise of staphylococcal super antigens in psoriatic patients: a case-control study. | Staphylococcus aureus, the major virulence factor of hospital and community acquired infections, secretes numerous exotoxins (super antigens), which may affect immunological and inflammatory status in psoriatic skin lesion. This study is designed to compare the S. aureus super antigens level in sera of psoriatic patien... | 25,147,719 | [
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The Association of Virulence Determinants of Uropathogenic Escherichia coli With Antibiotic Resistance. | The emergence of antimicrobial resistant strains of Escherichia coli has raised considerable interest in understanding the diversity and epidemiology of E. coli infections in humans. Virulence factors of E. coli determine the specific infections caused by this microorganism. This study aimed to determine the prevalence... | 25,147,722 | [
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Modern Multicomponent Reactions for better Drug Syntheses** | Multicomponent reaction (MCR) technology is now widely recognized for its impact on drug discovery projects and is strongly endorsed by industry as well as academia. However, still relatively few products based on MCRs are marketed or under development. This provides tremendous opportunities for organic chemists to sho... | 25,147,729 | [
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Role of Intravitreal Antivascular Endothelial Growth Factor Injections for Choroidal Neovascularization due to Choroidal Osteoma. | We treated 26 eyes of 25 young patients having a mean age of 30 years with intravitreal vascular endothelial growth factor (VEGF) inhibitor for choroidal new vessel (CNV) formation overlying choroidal osteoma over a mean follow-up of 26 months. Mean number of injections was 2.4 at 6 months, 3.2 at 12 months, and 5.5 at... | 25,147,732 | [
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Mechanical ventilation weaning in inclusion body myositis: feasibility of isokinetic inspiratory muscle training as an adjunct therapy. | Inclusion body myositis is a rare myopathy associated with a high rate of respiratory complications. This condition usually requires prolonged mechanical ventilation and prolonged intensive care stay. The unsuccessful weaning is mainly related to respiratory muscle weakness that does not promptly respond to immunosuppr... | 25,147,743 | [
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Anandamide inhibits breast tumor-induced angiogenesis. | Breast cancer is one of the most frequently diagnosed malignancies and a leading cause of cancer death in women. Great advances in the treatment of primary tumors have led to a significant increment in the overall survival rates, however recurrence and metastatic disease, the underlying cause of death, are still a medi... | 25,147,760 | [
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Osteitis pubis: can early return to elite competition be contemplated? | In elite athletes, osteitis pubis is a common painful degenerative process of the pubic symphysis and surrounding soft tissues and tendons. We report the diagnostic pathway and the rehabilitation protocol of six elite athletes with osteitis pubis in three different sports, and compare protocol stages and time to return... | 25,147,768 | [
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Obesity and obesity-associated cardiometabolic risk factors in indigenous Nenets women from the rural Nenets Autonomous Area and Russian women from Arkhangelsk city. | The prevalence of obesity and obesity-related conditions varies by population groups. Indigenous women of the circumpolar north are believed to be at high risk of obesity. We studied, first the obesity prevalence in indigenous Arctic women, Nenets, compared to urban Russian women. Second, the association between obesit... | 25,147,770 | [
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Targeting Glutathione S-transferase M4 in Ewing sarcoma. | Ewing sarcoma is a malignant pediatric bone and soft tissue tumor. Although the 5-year survival rate of localized disease approaches 75%, the prognosis of metastatic and/or therapy-resistant disease remains dismal despite the wide use of aggressive therapeutic strategies. We previously reported that high expression of ... | 25,147,782 | [
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Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial. | B vitamins play an important role in homocysteine metabolism, with vitamin deficiencies resulting in increased levels of homocysteine and increased risk for stroke. We performed a genome-wide association study (GWAS) in 2,100 stroke patients from the Vitamin Intervention for Stroke Prevention (VISP) trial, a clinical t... | 25,147,783 | [
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Peptide-ligand binding modeling of siRNA with cell-penetrating peptides. | The binding affinity of a series of cell-penetrating peptides (CPP) was modeled through docking and making use of the number of intermolecular hydrogen bonds, lipophilic contacts, and the number of sp3 molecular orbital hybridization carbons. The new ranking of the peptides is consistent with the experimentally determi... | 25,147,791 | [
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Studying the complex expression dependences between sets of coexpressed genes. | Organisms simplify the orchestration of gene expression by coregulating genes whose products function together in the cell. The use of clustering methods to obtain sets of coexpressed genes from expression arrays is very common; nevertheless there are no appropriate tools to study the expression networks among these se... | 25,147,825 | [
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Upregulation of pluripotency markers in adipose tissue-derived stem cells by miR-302 and leukemia inhibitory factor. | The expression pattern of pluripotency markers in adipose tissue-derived stem cells (ADSCs) is a subject of controversy. Moreover, there is no data about the signaling molecules that regulate these markers in ADSCs. In the present study, we studied the roles of leukemia inhibitory factor (LIF) and miR-302 in this regar... | 25,147,827 | [
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Antiviral action of synthetic stigmasterol derivatives on herpes simplex virus replication in nervous cells in vitro. | Polyfunctionalized stigmasterol derivatives, (22S,23S)-22,23-dihydroxystigmast-4-en-3-one (compound 1) and (22S,23S)-3β-bromo-5α,22,23-trihydroxystigmastan-6-one (compound 2), inhibit herpes simplex virus type 1 (HSV-1) replication and spreading in human epithelial cells derived from ocular tissues. Both compounds redu... | 25,147,828 | [
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δ-Cut decision-theoretic rough set approach: model and attribute reductions. | Decision-theoretic rough set is a quite useful rough set by introducing the decision cost into probabilistic approximations of the target. However, Yao's decision-theoretic rough set is based on the classical indiscernibility relation; such a relation may be too strict in many applications. To solve this problem, a δ-c... | 25,147,847 | [
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A cuckoo search algorithm for multimodal optimization. | Interest in multimodal optimization is expanding rapidly, since many practical engineering problems demand the localization of multiple optima within a search space. On the other hand, the cuckoo search (CS) algorithm is a simple and effective global optimization algorithm which can not be directly applied to solve mul... | 25,147,850 | [
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Effect of codon optimisation on the production of recombinant fish growth hormone in Pichia pastoris. | This study was established to test the hypothesis of whether the codon optimization of fish growth hormone gene (FGH) based on P. pastoris preferred codon will improve the quantity of secreted rFGH in culture supernatant that can directly be used as fish feed supplements. The optimized FGH coding sequence (oFGH) and na... | 25,147,851 | [
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Stress-strain relationship of Ca(OH)2-activated Hwangtoh concrete. | This study examined the stress-strain behavior of 10 calcium hydroxide (Ca(OH)2)-activated Hwangtoh concrete mixes. The volumetric ratio of the coarse aggregate (V agg) and the water-to-binder (W/B) ratio were selected as the main test variables. Two W/B ratios (25% and 40%) were used and the value of V agg varied betw... | 25,147,869 | [
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DPPA3 prevents cytosine hydroxymethylation of the maternal pronucleus and is required for normal development in bovine embryos. | Dppa3 has been described in mice as an important maternal factor contributed by the oocyte that participates in protecting the maternal genome from oxidation of methylated cytosines (5mC) to hydroxymethylated cytosines (5hmC). Dppa3 is also required for normal mouse preimplantation development. This gene is poorly cons... | 25,147,917 | [
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Selenite enhances immune response against Pseudomonas aeruginosa PA14 via SKN-1 in Caenorhabditis elegans. | Selenium (Se) is an important nutrient that carries out many biological processes including maintaining optimal immune function. Here, inorganic selenite (Se(IV)) was evaluated for its pathogen resistance and potential-associated factors in Caenorhabditis elegans. The immune effects of Se(IV) were investigated by exami... | 25,147,937 | [
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A Case of Orbital Metastasis of Uterine Leiomyosarcoma With Intracranial Extension Presenting With Proptosis. | A 57-year-old woman presented with protrusion of the OS 2 months in duration and decreased vision 1 month in duration. The patient was diagnosed with uterine leiomyosarcoma approximately 3 years before presentation. Lung and liver metastases were diagnosed by biopsy 1 year prior to this visit. CT revealed a solid mass ... | 25,147,935 | [
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Spectroscopic and permeation studies of phospholipid bilayers supported by a soft hydrogel scaffold. | Polarized attenuated total reflection infrared (ATR-IR) spectroscopy, fluorescence microscopy, and fluorescence spectroscopy were used to characterize a lipid coating composed of 70 mol % 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and 30 mol % cholesterol, supported on a spherical hydrogel scaffold. The fluores... | 25,147,944 | [
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CSF biomarkers and neuropsychological profiles in patients with cerebral small-vessel disease. | Despite existing criteria, differential diagnosis of Vascular Dementia (VD) and Alzheimer's disease (AD) remains difficult. The aim of this study is to figure out cognitive and biomarker profiles that may help to distinguish between VD, AD and AD + Cerebral Small Vessel Disease (CSVD). We examined a cohort of patients ... | 25,147,945 | [
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Investigation and control of anthrax outbreak at the human-animal interface, Bhutan, 2010. | In 2010, we investigated anthrax outbreak in Bhutan. A total of 43 domestic animals died, and cutaneous anthrax developed in 9 persons, and 1 died. All affected persons had contact with the carcasses of infected animals. Comprehensive preparedness and response guidelines are needed to increase public awareness of anthr... | 25,147,965 | [
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Sign inversion of circularly polarized luminescence by geometry manipulation of four naphthalene units introduced into a tartaric acid scaffold. | Tethering four 1- versus 2-naphthyls to the same chiral scaffold derived from tartaric acid led to oppositely signed circularly polarized luminescence (CPL) and circular dichroism (CD) in solution, which not only reveals the decisive role of the spatial arrangement of chromophores/fluorophores in determining the chirop... | 25,147,969 | [
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What I need to start my job: a wish list (positioning yourself for success in an academic or nonacademic environment). | Beginning practice as an orthopaedic traumatologist is an important event, when the groundwork is set up for the next few years of hard work. Plans must be made, resources allocated, staff hired, etc. to optimally support the newly practicing surgeon. Academic and nonacademic practice settings are possible, where the f... | 25,147,999 | [
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Improving business IQ in medicine through mentorship and education. | Business intelligence in the field of medicine, particularly with physicians, has been an abstract concept at best with no objective metric. Furthermore, in many arenas, it was taboo for medical students, residents, and physicians to discuss the business and finances of their work for fear that it would interfere with ... | 25,148,000 | [
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The stereotactic approach for mapping epileptic networks: a prospective study of 200 patients. | Stereoelectroencephalography (SEEG) is a methodology that permits accurate 3D in vivo electroclinical recordings of epileptiform activity. Among other general indications for invasive intracranial electroencephalography (EEG) monitoring, its advantages include access to deep cortical structures, its ability to localize... | 25,148,007 | [
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Correlation between magnetic resonance imaging grading and pathological grading in meningioma. | This study investigated the specific preoperative MRI features of patients with intracranial meningiomas that correlate with pathological grade and provide appropriate preoperative planning. From 2006 to 2012, 120 patients (36 men and 84 women, age range 20-89 years) with newly diagnosed symptomatic intracranial mening... | 25,148,010 | [
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Preference for women's body mass and waist-to-hip ratio in Tsimane' men of the Bolivian Amazon: biological and cultural determinants. | The issue of cultural universality of waist-to-hip ratio (WHR) attractiveness in women is currently under debate. We tested men's preferences for female WHR in traditional society of Tsimane'(Native Amazonians) of the Bolivian rainforest (N = 66). Previous studies showed preferences for high WHR in traditional populati... | 25,148,034 | [
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Optogenetic recruitment of dorsal raphe serotonergic neurons acutely decreases mechanosensory responsivity in behaving mice. | The inhibition of sensory responsivity is considered a core serotonin function, yet this hypothesis lacks direct support due to methodological obstacles. We adapted an optogenetic approach to induce acute, robust and specific firing of dorsal raphe serotonergic neurons. In vitro, the responsiveness of individual dorsal... | 25,148,042 | [
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Pharmacophore and docking-based virtual screening approach for the design of new dual inhibitors of Janus kinase 1 and Janus kinase 2. | Janus kinase 1 and 2, non-receptor protein tyrosine kinases, are implicated in various cancerous diseases. Involvement of these two enzymes in the pathways that stimulate cell proliferation in cancerous conditions makes them potential therapeutic targets for designing new dual-targeted agents for the treatment of cance... | 25,148,044 | [
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Parenting and the behavior problems of young children with an intellectual disability: concurrent and longitudinal relationships in a population-based study. | We examined parenting behaviors, and their association with concurrent and later child behavior problems. Children with an intellectual disability (ID) were identified from a UK birth cohort (N = 516 at age 5). Compared to parents of children without an ID, parents of children with an ID used discipline less frequent... | 25,148,056 | [
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The purported association between depression, aggression, and self-injury in people with intellectual disability: a critical review of the literature. | The prevalence of depression in individuals with an intellectual disability is estimated to lie between 3% and 6%. It has been suggested that symptoms of depression in this population might be atypical and include unusual features such as challenging behavior. However, there is significant disagreement regarding the us... | 25,148,058 | [
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Visibility through atmospheric haze and its relation to macular pigment. | A major factor limiting the visibility of distant targets is veiling attributed to atmospheric scattering, known commonly as haze. It has been suggested that yellow filters (in this case, the macular pigments, MPs) could selectively absorb this haze, thus extending visual range. This study is an empirical test of the v... | 25,148,065 | [
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Microbial communities of three sympatric Australian stingless bee species. | Bacterial symbionts of insects have received increasing attention due to their prominent role in nutrient acquisition and defense. In social bees, symbiotic bacteria can maintain colony homeostasis and fitness, and the loss or alteration of the bacterial community may be associated with the ongoing bee decline observed... | 25,148,082 | [
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Consumer e-health solutions: the cure for Baumol's disease? | Baumol's disease is the fact that costs in persistently labour-intensive sectors such as healthcare do not drop, despite increased use of technology. The idea of consumer e-health solutions is seductive, because it provides one option for treating Baumol's disease. However, barriers to the implementation of these solut... | 25,148,118 | [
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Facilitating the appropriate use of e-health solutions. | In this issue, the lead article proposes that e-health technologies should be used more broadly and that patients should have greater access to their information through such technologies. The Canadian Medical Protective Association (CMPA) agrees with this statement and suggests that to facilitate the timely and approp... | 25,148,123 | [
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Solutions for patient activation will yield the greatest benefit. | In the context of fiscal scarcity and abundant consumer health technologies, robust choices must be made. In this article, the authors assert that technologies that will yield the greatest return on investment for patients, providers and health system payers should be prioritized. They present three technology solution... | 25,148,125 | [
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Node fingerprinting: an efficient heuristic for aligning biological networks. | With the continuing increase in availability of biological data and improvements to biological models, biological network analysis has become a promising area of research. An emerging technique for the analysis of biological networks is through network alignment. Network alignment has been used to calculate genetic dis... | 25,148,127 | [
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Contractile force is enhanced in Aortas from pendrin null mice due to stimulation of angiotensin II-dependent signaling. | Pendrin is a Cl-/HCO3- exchanger expressed in the apical regions of renal intercalated cells. Following pendrin gene ablation, blood pressure falls, in part, from reduced renal NaCl absorption. We asked if pendrin is expressed in vascular tissue and if the lower blood pressure observed in pendrin null mice is accompani... | 25,148,130 | [
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An alumina stabilized ZnO-graphene anode for lithium ion batteries via atomic layer deposition. | Atomic layer deposition (ALD) was applied to deposit ZnO on graphene aerogel, and this composite was used as an anode material for lithium ion batteries. This electrode material was further modified by an ultrathin Al2O3 layer via ALD to stabilize its electrochemical stability. These two metal oxides were uniformly imm... | 25,148,141 | [
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Conformationally switchable non-cyclic tetrapyrrole receptors: synthesis of tetrakis(1H-pyrrole-2-carbaldehyde) derivatives and their anion binding properties. | A series of tetrakis(1H-pyrrole-2-carbaldehyde) receptors (2, 4, and 6) were synthesized in two steps from commercially available starting materials. The anion binding properties of these receptors can be tuned through electronic switching to stabilize a conformation displaying high affinity for the dihydrogenphosphate... | 25,148,146 | [
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Pitfalls and pearls in MRI of the knee. | The purpose of this article is to review the common pitfalls in MRI of the knee and pearls on how to avoid them. MRI of the knee is highly accurate in evaluation of internal derangements of the knee. However, a variety of potential pitfalls in interpretation of abnormalities related to the knee have been identified, pa... | 25,148,154 | [
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Outpatient falls prevention program outcome: an increase, a plateau, and a decrease in incident reports. | We implemented an outpatient falls guideline in 2008 in the department of radiology. Here, we describe our multiyear experience. This was a retrospective study conducted between April 2006 and September 2013 to investigate outpatient falls. The span of the study was divided into eight periods. The incident reporting sy... | 25,148,166 | [
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0.2715513,
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0.03852518,
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0.1876692,
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0.3134771,
0.1631448,
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0.005530333,
0.1690011,
0.02271688,... |
Retrospective research in radiology from concept to publication: a stepwise guide for trainees and mentors. | The purpose of this article is to describe a step-by-step approach to the successful mentorship of trainees completing retrospective radiology research projects. The topics addressed include selection of a mentor and mentee and the selection, planning, initiation, and completion of a retrospective research project. Men... | 25,148,188 | [
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0.151148... |
Differences between wavefront and subjective refraction for infrared light. | To determine the accuracy of objective wavefront refractions for predicting subjective refractions for monochromatic infrared light. Objective refractions were obtained with a commercial wavefront aberrometer (COAS, Wavefront Sciences). Subjective refractions were obtained for 30 subjects with a speckle optometer valid... | 25,148,218 | [
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Identification of oncogenic mutations and gene fusions in the follicular variant of papillary thyroid carcinoma. | The diagnosis of the follicular variant of papillary thyroid carcinoma (FVPTC) is increasingly common. Recent studies have suggested that FVPTC is heterogeneous and comprises multiple tumor types with distinct biological behaviors and underlying genetics. The purpose of this work was to identify the prevalence of mutat... | 25,148,236 | [
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Evaluation of naturally acquired IgG antibodies to a chimeric and non-chimeric recombinant species of Plasmodium vivax reticulocyte binding protein-1: lack of association with HLA-DRB1*/DQB1* in malaria exposed individuals from the Brazilian Amazon. | The development of modular constructs that include antigenic regions targeted by protective immune responses is an attractive approach for subunit vaccine development. However, a main concern of using these vaccine platforms is how to preserve the antigenic identity of conformational B cell epitopes. In the present stu... | 25,148,251 | [
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Chronic HCV infection affects the NK cell phenotype in the blood more than in the liver. | Although epidemiological and functional studies have implicated NK cells in protection and early clearance of HCV, the mechanism by which they may contribute to viral control is poorly understood, particularly at the site of infection, the liver. We hypothesized that a unique immunophenotypic/functional NK cell signatu... | 25,148,254 | [
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Protective effects of the sodium/calcium exchanger inhibitor on endothelial dysfunction induced by high glucose. | This study was designed to investigate the protective effects of KB-R7943, an inhibitor of sodium/calcium exchanger (NCX) on endothelial dysfunction induced by high glucose in endothelial cells. NCX expression, NCX activity and oxidative stress index were determined after endothelial cells were exposed to high glucose ... | 25,148,264 | [
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DRUGS system enhancing adherence of Chinese surgeons to antibiotic use guidelines during perioperative period. | Irrational use of antimicrobial agents for preventing postoperative SSIs is a common phenomenon in China, which results in more bacterial resistance, higher hospital infection rates, extra costs of antimicrobial agents. The aim of the study is to evaluate the effect of Drug Rational Usage Guidelines System (DRUGS) on t... | 25,148,306 | [
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Silk damping at a redshift of a billion: new limit on small-scale adiabatic perturbations. | We study the dissipation of small-scale adiabatic perturbations at early times when the Universe is hotter than T≃0.5 keV. When the wavelength falls below the damping scale k(D)(-1), the acoustic modes diffuse and thermalize, causing entropy production. Before neutrino decoupling, k(D) is primarily set by the neutrino... | 25,148,313 | [
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0.3193947,
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Determination of the η(')-proton scattering length in free space. | Taking advantage of both the high mass resolution of the COSY-11 detector and the high energy resolution of the low-emittance proton beam of the cooler synchrotron COSY, we determine the excitation function for the pp→ppη(') reaction close to threshold. Combining these data with previous results, we extract the scatter... | 25,148,320 | [
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0.3337089,
0.3567357,
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-0.019137... |
Engineering frequency-time quantum correlation of narrow-band biphotons from cold atoms. | The nonclassical photon pair, generated via a parametric process, is naturally endowed with a specific form of frequency-time quantum correlations. Here, we report complete control of frequency-time quantum correlations of narrow-band biphotons generated via spontaneous four-wave mixing in a cold atomic ensemble. We ha... | 25,148,327 | [
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Interfacing superconducting qubits and telecom photons via a rare-earth-doped crystal. | We propose a scheme to couple short single photon pulses to superconducting qubits. An optical photon is first absorbed into an inhomogeneously broadened rare-earth doped crystal using controlled reversible inhomogeneous broadening. The optical excitation is then mapped into a spin state using a series of π pulses and ... | 25,148,328 | [
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TL1A increases expression of CD25, LFA-1, CD134 and CD154, and induces IL-22 and GM-CSF production from effector CD4 T-cells. | Elevated levels of the cytokine TL1A is associated with several autoimmune diseases e.g. rheumatoid arthritis and inflammatory bowel disease. However, the exact role of TL1A remains elusive. In this study, we investigated the function of TL1A in a pro-inflammatory setting. We show that TL1A together with IL-12, IL-15 a... | 25,148,371 | [
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Efficacy and safety of intravesical onabotulinumtoxinA injection on elderly patients with chronic central nervous system lesions and overactive bladder. | Intravesical injection of onabotulinumtoxinA is an effective treatment for overactive bladder (OAB). Nonetheless, the treatment outcome is unclear in OAB patients with central nervous system (CNS) lesions. This study evaluated the efficacy and safety of intravesical onabotulinumtoxinA treatment in elderly patients with... | 25,148,378 | [
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Outcomes of pancreas retransplantation after simultaneous kidney-pancreas transplantation are comparable to pancreas after kidney transplantation alone. | There is a paucity of contemporary data describing the results of pancreas retransplantation (PRT). As a measure of utility, we wished to determine whether PRT could produce equivalent short-term and long-term recipient outcomes to primary pancreas after kidney (PAK) transplantation. Retrospective analysis of 96 consec... | 25,148,379 | [
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American Organization of Nurse Executives Care Innovation and Transformation program: improving care and practice environments. | The American Organization of Nurse Executives conducted an evaluation of the hospitals participating in the Care Innovation and Transformation (CIT) program. A total of 24 hospitals participated in the 2-year CIT program from 2012 to 2013. Reported outcomes include increased patient satisfaction, decreased falls, and r... | 25,148,395 | [
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Designing tomorrow from the other side of the bed. | The author poses insights about transitions in the development of collaborative relationships between medical students and nurses. | 25,148,397 | [
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Magnet nurse administrator attitudes and opportunities: toward improving lesbian, gay, bisexual, or transgender-specific healthcare. | This study explored Magnet® hospital chief nursing officers' (CNOs') attitudes toward gays and lesbians and the impact that these attitudes have on providing advocacy for lesbian, gay, bisexual, or transgender (LGBT) patients and staff. Homonegativity encompasses both heterosexism and homophobia and has profound effect... | 25,148,402 | [
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-0.1370274,
-0.2569345,
-0.5918705,
-0.09668273,
0.1031639,
0.057... |
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