title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Autophagy and amino acid metabolism in the brain: implications for epilepsy. | Autophagy is a catabolic pathway responsible for the maintenance of the tissue and organism homeostasis. Several amino acids regulate autophagic activity in different tissues, such as liver and muscle, but much less is known about this regulation in the brain. The lack of autophagy in neurons leads to a strong neurodeg... | 25,145,921 | [
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Selective Embolization of Systemic Collaterals for the Treatment of Recurrent Hemoptysis Secondary to the Unilateral Absence of a Pulmonary Artery in a Child. | The unilateral absence of the pulmonary artery (UAPA) is a rare anomaly. Hemoptysis due to systemic collaterals is one of the most common complications of UAPA. To the best of the authors' knowledge, the utility of selective embolization for the treatment of this condition in children has not been reported previously. ... | 25,145,922 | [
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Ebstein anomaly: assessment, management, and timing of intervention. | Ebstein anomaly is a developmental abnormality of the tricuspid valve and right ventricle that results in tricuspid regurgitation and right heart enlargement. Because of the variation in clinical severity and associated findings, patients require a detailed, well-tailored evaluation. For these reasons, management of ad... | 25,145,925 | [
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Surface-confined single-layer covalent organic framework on single-layer graphene grown on copper foil. | The integration of 2D covalent organic frameworks (COFs) with atomic thickness with graphene will lead to intriguing two-dimensional materials. A surface-confined covalently bonded Schiff base network was prepared on single-layer graphene grown on copper foil and the dynamic reaction process was investigated with scann... | 25,145,927 | [
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Long-term outcome after arthroscopic rotator cuff treatment. | Arthroscopic techniques have become the gold standard in the operative management of several pathologic conditions of the shoulder. The purpose of this systematic review was to present the long-term outcomes following arthroscopic treatment of rotator cuff pathology. A comprehensive literature review was performed to i... | 25,145,945 | [
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Role of laparoscopy in patients with peritoneal metastases considered for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC). | We hypothesized that diagnostic laparoscopy (DL) was feasible for the evaluation of patients with peritoneal carcinomatosis (PC) undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS + HIPEC). A retrospective review of PC patients treated from January 2010 to April 2013 was conducted. Data... | 25,145,962 | [
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An ESIPT based fluorescent probe for highly selective and ratiometric detection of periodate. | Periodate is widely used in organic and bioorganic chemistry, and also related to food and environmental safety. To best of our knowledge, there is no efficient tools reported for simultaneously quantifying periodate with high accuracy and discriminating periodate from other forms of iodine. We have synthesized, charac... | 25,145,984 | [
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Osteoblastic cell response to spark plasma-sintered zirconia/titanium cermets. | Ceramic/metal composites, cermets, arise from the idea to combine the dissimilar properties in the pure materials. This work aims to study the biocompatibility of new micro-nanostructured 3 Y-TZP/Ti materials with 25, 50 and 75 vol.% Ti, which have been successfully obtained by spark slasma sintering technology, as wel... | 25,145,987 | [
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Cell-to-cell transfer of HIV infection: implications for HIV viral persistence. | A major research priority for HIV eradication is the elucidation of the events involved in HIV reservoir establishment and persistence. Cell-to-cell transmission of HIV represents an important area of study as it allows for the infection of cell types which are not easily infected by HIV, leading to the establishment o... | 25,146,006 | [
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Down-regulation of inflammatory mediator synthesis and infiltration of inflammatory cells by MMP-3 in experimentally induced rat pulpitis. | Matrix metalloproteinase (MMP)-3 is a member of the MMP family that degrades the extracellular matrix. Application of MMP-3 to injured pulp tissue induces angiogenesis and wound healing, but its anti-inflammatory effects are still unclear. Here, we evaluated the anti-inflammatory functions of MMP-3 in vitro and in vivo... | 25,146,022 | [
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Correlation of root dentin thickness and length of roots in mesial roots of mandibular molars. | The purpose of this study was to analyze the relation of tooth length and distal wall thickness of mesial roots in mandibular molars at different locations (ie, 2 mm below the furcation and at the junction between the middle and apical third). Forty-five mandibular first molars were taken, and the length of each tooth ... | 25,146,027 | [
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The Making Cases Count intiative. | Given the challenges faced, how can homeopaths communicate the power and scope of the therapeutic system of homeopathy? Homeopaths need to communicate to patients, the public and media, other healthcare professionals, healthcare researchers, and funders of healthcare (healthcare insurers, those who commission healthcar... | 25,146,064 | [
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Reduction of surgery rate in endometriosis patients who take Chinese medicine: a population-based retrospective cohort study. | Female patients have frequently utilized Chinese medicine (CM) to treat symptoms that could possibly be related to endometriosis. The objective of this population-based retrospective cohort study was to evaluate the relationship between CM use and subsequent surgery among patients with endometriosis. A total of 8,283 C... | 25,146,066 | [
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Measuring body constitution: validation of the Body Constitution Questionnaire (BCQ) in Hong Kong. | The Body Constitution Questionnaire (BCQ) was developed in Taiwan to classify people into body constitution (BC) types based on Traditional Chinese Medicine (TCM) theories. Since the culture of Hong Kong is different from Taiwan, the BCQ must be validated before a wider application can be preceded. To adapt and validat... | 25,146,072 | [
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Detection of CoHV-1 by loop-mediated amplification (LAMP). Application of LAMP for CoHV-1 incidence monitoring in domestic pigeons. | The occurrence of Columbid herpesvirus-1 (CoHV-1) in domestic pigeons presents a potential threat for their husbandry and trade. CoHV-1 causes Smadel disease among pigeons but may not be manifested by any clinical signs and complicates secondary infections. The material for our study originated from 42 domestic pigeons... | 25,146,091 | [
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Drug conjugation to cyclic peptide-polymer self-assembling nanotubes. | We show for the first time how polymeric nanotubes (NTs) based on self-assembled conjugates of polymers and cyclic peptides can be used as an efficient drug carrier. RAPTA-C, a ruthenium-based anticancer drug, was conjugated to a statistical co-polymer based on poly(2-hydroxyethyl acrylate) (pHEA) and poly(2-chloroethy... | 25,146,103 | [
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Diffusion weighted magnetic resonance imaging demonstrates tumor response following palliative embolization of a recurrent shoulder plasmacytoma. | We report the palliative embolization and functional imaging follow-up of a recurrent shoulder plasmacytoma. The multiple myeloma patient complained of severe pain and discomfort, while he could not tolerate further chemotherapy. The left shoulder lesion had earlier received a high dose of irradiation. Thus, the well-v... | 25,146,111 | [
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Frequency matters: beta-band subthalamic nucleus deep-brain stimulation induces Parkinsonian-like blink abnormalities in normal rats. | The synchronized beta-band oscillations in the basal ganglia-cortical networks in Parkinson's disease (PD) may be responsible for PD motor symptoms or an epiphenomenon of dopamine loss. We investigated the causal role of beta-band activity in PD motor symptoms by testing the effects of beta-frequency subthalamic nucleu... | 25,146,113 | [
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Pollutant toxicity and detoxification by humic substances: mechanisms and quantitative assessment via luminescent biomonitoring. | The paper considers mechanisms of detoxification of pollutant solutions by water-soluble humic substances (HSs), natural detoxifying agents. The problems and perspectives of bioassay application for toxicity monitoring of complex solutions are discussed from ecological point of view. Bioluminescence assays based on mar... | 25,146,119 | [
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Evolution of dissolved organic matter during abiotic oxidation of coal tar--comparison with contaminated soils under natural attenuation. | In former coal transformation plants (coking and gas ones), the major organic contamination of soils is coal tar, mainly composed of polycyclic aromatic compounds (PACs). Air oxidation of a fresh coal tar was chosen to simulate the abiotic natural attenuation impact on PAC-contaminated soils. Water-leaching experiments... | 25,146,121 | [
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Dimeric tetrathiafulvalene linked to pseudo-ortho-[2.2]paracyclophane: chiral electrochromic properties and use as a chiral dopant. | A dimeric tetrathiafulvalene installed into a chiral pseudo-ortho-[2.2]paracyclophane framework was synthesized as a novel chiral electrochromic material. This compound exhibited pronounced chiroptical properties in the UV-Vis-NIR range depending on its redox states without racemization. Each enantiomer was examined as... | 25,146,126 | [
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Water activation by small free ruthenium oxide clusters. | The reactions of ruthenium clusters, Rux(+) (x = 2-5), and ruthenium oxide clusters, RuxOy(+) (x = 2-5, y = 1-2), with water molecules have been investigated by gas phase ion trap mass spectrometry and first principle density functional calculations. The joint experimental and theoretical study reveals that the reactio... | 25,146,165 | [
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[Prevalence of anal-vaginal colonization of Streptococcus agalactiae in third trimester of pregnancy and susceptibility to macrolides and lincosamides, in pregnant women controlled at Clínica Alemana Temuco, Southern Chile]. | Streptococcus agalactiae (GBS) is the most common agent in early neonatal sepsis. Strategies incorporating universal screening for maternal colonization show the lowest rates of perinatal infection. A significant increase in resistance to erythromycin and clindamycin by GBS has been reported around the world. There are... | 25,146,205 | [
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Nanoscale nickel oxide/nickel heterostructures for active hydrogen evolution electrocatalysis. | Active, stable and cost-effective electrocatalysts are a key to water splitting for hydrogen production through electrolysis or photoelectrochemistry. Here we report nanoscale nickel oxide/nickel heterostructures formed on carbon nanotube sidewalls as highly effective electrocatalysts for hydrogen evolution reaction wi... | 25,146,255 | [
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Political science. Reverse-engineering censorship in China: randomized experimentation and participant observation. | Existing research on the extensive Chinese censorship organization uses observational methods with well-known limitations. We conducted the first large-scale experimental study of censorship by creating accounts on numerous social media sites, randomly submitting different texts, and observing from a worldwide network ... | 25,146,296 | [
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Effect of temperature and pressure on characteristics and reactivity of biomass-derived chars. | This study evaluates the influence of pyrolysis temperature (350-450°C) and pressure (0.1-2.0MPa) on product yields and char properties. Spruce chars were produced under slow pyrolysis conditions in a fixed bed reactor. Special attention was devoted to the study of the oxidation reactivity of the produced chars, and it... | 25,146,312 | [
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Triple valve surgery in the modern era: short- and long-term results from a single centre. | Triple valve surgery (TVS) is still a challenge for surgeons because of prolonged cardiopulmonary bypass (CPB) and myocardial ischaemic times. The reported operative mortality rate for TVS ranges between 2.5 and 25%; long-term survival is also diminished, with reported survival rates at 5 and 10 years of 75-82 and 61-7... | 25,146,323 | [
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Developmental markers of ganglion cells in the enteric nervous system and their application for evaluation of Hirschsprung disease. | Hirschsprung disease (HSCR) is a congenital disease resulting from failure of neural crest-derived ganglion cells to colonize the colon. Conventional diagnostic methods are insufficient for evaluating the 'functional' prognosis of HSCR. In order to elucidate the maturation of ganglion cells, 17 immunohistochemical mark... | 25,146,344 | [
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Inferring human mobility using communication patterns. | Understanding the patterns of mobility of individuals is crucial for a number of reasons, from city planning to disaster management. There are two common ways of quantifying the amount of travel between locations: by direct observations that often involve privacy issues, e.g., tracking mobile phone locations, or by est... | 25,146,347 | [
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On copper diffusion in silicon measured by glow discharge mass spectrometry. | Copper contamination occurs frequently in silicon for photovoltaic applications due to its very fast diffusion coupled with a low solid solubility, especially at room temperature. The combination of these properties exerts a challenge on the direct analysis of Cu bulk concentration in Si by sputtering techniques like g... | 25,146,357 | [
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Wheat allergy in children - new tools for diagnostics. | The detection of wheat-specific IgE in children often leads to a suspicion of wheat allergy, but little information is available on the most reliable wheat allergens for predicting clinical reactivity. To evaluate the role of allergenic components of wheat in wheat allergy diagnostics. One hundred and eight children (m... | 25,146,380 | [
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Liquid chromatography with mass spectrometry method based two-step precursor ion scanning for the structural elucidation of flavonoids. | Plant flavonoids are very important secondary metabolites for insect and virus control of their host plant and are potent nutrients for humans. To be able to understand the bioavailability and functions of plant flavonoids, it is necessary to reveal their exact chemical structures. Liquid chromatography with tandem mas... | 25,146,381 | [
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Twist1 induces endothelial differentiation of tumour cells through the Jagged1-KLF4 axis. | The mechanisms controlling tumour-induced angiogenesis are presently not clear. In principle, angiogenesis can be achieved through the activation of endothelial cells in existing vessels or by transdifferentiation of tumour cells into endothelial cells. However, whether tumour cells can go through a prior epithelial-me... | 25,146,389 | [
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Measurement of greenhouse gas flux from agricultural soils using static chambers. | Measurement of greenhouse gas (GHG) fluxes between the soil and the atmosphere, in both managed and unmanaged ecosystems, is critical to understanding the biogeochemical drivers of climate change and to the development and evaluation of GHG mitigation strategies based on modulation of landscape management practices. Th... | 25,146,426 | [
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Glucocorticoid-induced leucine zipper (GILZ) controls inflammation and tissue damage after spinal cord injury. | Spinal cord injury (SCI) occurs following damage to the spinal column. Following trauma, tissue damage is further exacerbated by a secondary damage due to a SCI-activated inflammatory process. Control of leukocytes activity is essential to therapeutic inhibition of the spinal cord damage to ameliorate the patient's con... | 25,146,427 | [
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Dose heterogeneity correction for low-energy brachytherapy sources using dual-energy CT images. | Permanent seed implant brachytherapy is currently used for adjuvant radiotherapy of early stage prostate and breast cancer patients. The current standard for calculation of dose around brachytherapy sources is based on the AAPM TG-43 formalism, which generates the dose in a homogeneous water medium. Recently, AAPM TG-1... | 25,146,446 | [
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Altered cerebrovascular reactivity velocity in mild cognitive impairment and Alzheimer's disease. | Interindividual variation in neurovascular reserve and its relationship with cognitive performance is not well understood in imaging in neurodegeneration. We assessed the neurovascular reserve in amnestic mild cognitive impairment (aMCI) and Alzheimer's dementia (AD). Twenty-eight healthy controls (HC), 15 aMCI, and 20... | 25,146,454 | [
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Oxygenated monoterpenes citral and carvacrol cause oxidative damage in Escherichia coli without the involvement of tricarboxylic acid cycle and Fenton reaction. | Oxygenated monoterpenes citral and carvacrol are common constituents of many essential oils (EOs) that have been extensively studied as antimicrobial agents but whose mechanisms of microbial inactivation have not been totally elucidated. A recent study described a mechanism of Escherichia coli death for (+)-limonene, a... | 25,146,464 | [
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Engineering the donor selectivity of D-fructose-6-phosphate aldolase for biocatalytic asymmetric cross-aldol additions of glycolaldehyde. | D-Fructose-6-phosphate aldolase (FSA) is a unique catalyst for asymmetric cross-aldol additions of glycolaldehyde. A combination of a structure-guided approach of saturation mutagenesis, site-directed mutagenesis, and computational modeling was applied to construct a set of FSA variants that improved the catalytic effi... | 25,146,467 | [
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Effect of different breath alcohol concentrations on driving performance in horizontal curves. | Driving under the influence of alcohol on curved roadway segments has a higher risk than driving on straight segments. To explore the effect of different breath alcohol concentration (BrAC) levels on driving performance in roadway curves, a driving simulation experiment was designed to collect 25 participants' driving ... | 25,146,494 | [
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The selective noradrenergic reuptake inhibitor reboxetine restores spatial learning deficits, biochemical changes, and hippocampal synaptic plasticity in an animal model of depression. | Depression is a major psychiatric illness that is associated with cognitive dysfunctions. The underlying mechanism of depression-associated memory impairment is unclear. Previously, we showed altered hippocampal synaptic plasticity in an animal model of depression. Although several antidepressants are beneficial in the... | 25,146,499 | [
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[Results of surgical treatment of cholelithiasis by laparotomic and minimally invasive accesses]. | The article presents the results of surgical treatment of 1038 patients with cholelithiasis, acute and chronic calculous cholecystitis and complicated forms of the disease. Operations were performed with traditional laparotomic and minimally invasive approaches. Indications for choosing access, as well as the advantage... | 25,146,538 | [
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[The impact of thromboprophylaxis with enoxaparin on bleeding rate in rejuvenating facelift procedures]. | A retrospective study on safety of prophylactic use of Enoxaparin in rejuvenating face lift procedures. The prophylactic use of Enoxaparin was not found to be associated with increased perioperative bleeding or higher incidence of postoperative hematomas requiring reoperation. | 25,146,545 | [
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The control of insulin secretion by adipokines: current evidence for adipocyte-beta cell endocrine signalling in metabolic homeostasis. | Metabolic homeostasis is maintained by the coordinated action of multiple organ systems. Insulin secretion is often enhanced during obesity or insulin resistance to maintain glucose and lipid homeostasis, whereas a loss of insulin secretion is associated with type 2 diabetes. Adipocytes secrete hormones known as adipok... | 25,146,550 | [
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Sonochemistry: what potential for conversion of lignocellulosic biomass into platform chemicals? | This Review focuses on the use of ultrasound to produce chemicals from lignocellulosic biomass. However, the question about the potential of sonochemistry for valorization/conversion of lignocellulosic biomass into added-value chemicals is rather conceptual. Until now, this technology has been mainly used for the produ... | 25,146,583 | [
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Prevalence of osteoporosis and vertebral fractures and related factors in patients with ankylosing spondylitis. | Osteoporosis and vertebral factures are well recognized features in patients with ankylosing spondylitis (AS). The aim of this study was to investigate the prevalence and risk factors of osteoporosis and vertebral fractures in patients with AS. Fifty-nine AS patients and 40 healthy controls were enrolled. Bone mineral ... | 25,146,606 | [
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Pathogenic analysis in different types of orthopedic implant infections. | Diversity of orthopedic infections with various local environments affects the pattern and prevalence of pathogens. It is not well-characterized whether different pathogens have different propensity to cause different types of orthopedic infections. We aimed to investigate the frequency of different pathogens derived f... | 25,146,607 | [
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The evolution of the four subunits of voltage-gated calcium channels: ancient roots, increasing complexity, and multiple losses. | The alpha subunits of voltage-gated calcium channels (Ca(v)s) are large transmembrane proteins responsible for crucial physiological processes in excitable cells. They are assisted by three auxiliary subunits that can modulate their electrical behavior. Little is known about the evolution and roles of the various subun... | 25,146,647 | [
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[Connexin-43 antibodies in intraoperative diagnosis of experimental poorly differentiated gliomas]. | Fluorescent diagnosis was first proposed in the early XX century and has been used in neurosurgery for about 15 years. The method relies on selective accumulation of strongly fluorescent protoporphyrin IX in tumor cells. Over the past years, the method of intraoperative fluorescence diagnosis has occupied its niche in ... | 25,146,651 | [
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Feline cutaneous lymphocytosis: case report and summary of the literature. | Feline cutaneous lymphocytosis is a rare disease characterized by proliferation of T and/or B lymphocytes in the dermis. Although some of the clinical and histopathologic findings of this condition can overlap with cutaneous lymphoma, it is important to distinguish these entities since their treatment and clinical outc... | 25,146,663 | [
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Cell cycle-dependent O-GlcNAc modification of tobacco histones and their interaction with the tobacco lectin. | The Nicotiana tabacum agglutinin or Nictaba is a nucleocytoplasmic lectin that is expressed in tobacco after the plants have been exposed to jasmonate treatment or insect herbivory. Nictaba specifically recognizes GlcNAc residues. Recently, it was shown that Nictaba is interacting in vitro with the core histone protein... | 25,146,688 | [
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Effective light absorption and absolute electron transport rates in the coral Pocillopora damicornis. | Pulse Amplitude Modulation (PAM) fluorometry has been widely used to estimate the relative photosynthetic efficiency of corals. However, both the optical properties of intact corals as well as past technical constrains to PAM fluorometers have prevented calculations of the electron turnover rate of PSII. We used a new ... | 25,146,689 | [
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Impact of Sod on the expression of stress-related genes in Listeria monocytogenes 4b G with/without paraquat treatment. | Listeria monocytogenes is a foodborne pathogen that causes listeriosis. Paraquat can generate reactive oxygen species (ROS) in cells, which results in oxidative stress. It was first shown that 1 mM of paraquat inhibited the growth rate of a superoxide dismutase (sod)-deletion mutant (∆sod) generated from L. monocytogen... | 25,146,690 | [
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Implantable defibrillators for secondary prevention of sudden cardiac death in cardiac surgery patients with perioperative ventricular arrhythmias. | Randomized studies of implantable cardioverter defibrillators (ICD) have excluded sudden cardiac death survivors who had revascularization before or after an arrhythmic event. To evaluate the role of ICD and the effects of clinical variables including degree of revascularization, we studied cardiac surgery patients who... | 25,146,702 | [
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Addition of bortezomib to standard dose chop chemotherapy improves response and survival in relapsed mantle cell lymphoma. | The proteasome inhibitor, bortezomib, potentially increases cell sensitivity to chemotherapy. This study was performed to determine the overall response rate (ORR), overall survival (OS), progression-free survival (PFS) and toxicity of CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) compared to CHOP ... | 25,146,720 | [
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A mouse polyomavirus-encoded microRNA targets the cellular apoptosis pathway through Smad2 inhibition. | Some viruses and most eukaryotic cells have microRNAs that regulate the expression of many genes. Although many viral miRNAs have been identified, only a few have been included in in vivo functional studies. Here we show that a Py-encoded miRNA downregulates the expression of the pro-apoptotic factor Smad2, resulting i... | 25,146,733 | [
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[Effects of postconditioning on autophagy of lung ischemic reperfusion injury in rats]. | To explore the effects of postconditioning on autophagy of lung injury in situ during lung ischemic reperfusion. Twenty-four male Sprague-Dawley rats were randomly divided into 3 groups of sham-operated (S), ischemic-reperfusion (I/R) and ischemic postconditioning (IpostC) (n = 8 each). All underwent left thoracotomy a... | 25,146,749 | [
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Chemical composition and phytotoxic effects of essential oils obtained from Ailanthus altissima (Mill.) swingle cultivated in Tunisia. | Ailanthus altissima Mill. Swingle (Simaroubaceae), also known as tree of heaven, is used in the Chinese traditional medicine as a bitter aromatic drug for the treatment of colds and gastric diseases. In Tunisia, Ailanthus altissima is an exotic tree, which was introduced many years ago and used particularly as a street... | 25,146,765 | [
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[Preoperative tests recommendations in adult patients for ambulatory surgery]. | Anesthetic assessment traditionally included a series of laboratory tests intended to detect undiagnosed diseases, and to ensure that the patient undergoes surgery following safety criteria. These tests, without a specific clinical indication, are expensive, of questionable diagnostic value and often useless. In the co... | 25,146,773 | [
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Influence of post-transplant immunosuppressive therapy on gastrointestinal transit using biomagnetic method: a pilot study. | Immunosuppressive therapy after kidney transplant is necessary to prevent allograft rejection and it is the cause of several gastrointestinal (GI) disorders that have been scantily studied. This study was aimed at investigating the influence of triple immunosuppressive therapy on GI transit in renal transplant patients... | 25,146,844 | [
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Decreased expression of HLA-DQ and HLA-DR on cells of the monocytic lineage in cystic fibrosis. | We studied HLA class II molecules on blood monocyte subsets, blood dendritic cells, sputum macrophages, and monocyte-derived macrophages at the protein (flow cytometry) and mRNA level (RT-PCR) in adult patients with cystic fibrosis (CF) and healthy control subjects as putative contributors to the CF phenotype. In healt... | 25,146,850 | [
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Healthy Spaces in Meaningful Places: The Rural Church and Women's Health Promotion. | The influence of place on health is beginning to be addressed in health research. Current understanding of rural places, however, remains in a state of disequilibrium, balancing between geographic and sociocultural positions. This article illuminates the significance of place for rural women's experiences of health pro... | 25,146,851 | [
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Comparison of cancer stem cell antigen expression by tumor cell lines and by tumor biopsies from dogs with melanoma and osteosarcoma. | Cancer stem cells (CSCs) represent a small subpopulation of tumor cells that play a critical role in initiating and sustaining tumor growth. However, we currently have an incomplete understanding of the expression patterns of CSC antigens in tumors of dogs, nor do we understand how expression of these antigens vary bet... | 25,146,881 | [
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Relationship between universal health outcome priorities and willingness to take medication for primary prevention of myocardial infarction. | To determine how well universal health outcome priorities represent individuals' preferences in specific clinical situations. Observational cohort study. Community. Community-dwelling adults aged 65 and older (N = 357). Participants used three tools assessing universal health outcome priorities related to two common tr... | 25,146,885 | [
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Characteristics associated with physical activity among independently ambulant children and adolescents with unilateral cerebral palsy. | This study aimed to quantify the contribution of physical, personal and environmental characteristics to physical activity among independently ambulant children with unilateral cerebral palsy (CP). One-hundred and two children with unilateral CP (52 males, 50 females; 52 right hemiplegia; mean age 11y 3mo, range 8-17y ... | 25,146,888 | [
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Mannosylated lipoarabinomannan in serum as a biomarker candidate for subclinical bovine tuberculosis. | Early and unambiguous detection of bovine tuberculosis (bTB), a significant disease of cattle worldwide, is necessary to control the spread of infection to other animals and humans. Current testing strategies are laborious, time consuming and heavily reliant on host responses that do not distinguish bTB from other myco... | 25,146,892 | [
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Platinum-free binary Co-Ni alloy counter electrodes for efficient dye-sensitized solar cells. | Dye-sensitized solar cells (DSSCs) have attracted growing interest because of their application in renewable energy technologies in developing modern low-carbon economies. However, the commercial application of DSSCs has been hindered by the high expenses of platinum (Pt) counter electrodes (CEs). Here we use Pt-free b... | 25,146,894 | [
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Intermittent hypoxia preconditioning-induced epileptic tolerance by upregulation of monocarboxylate transporter 4 expression in rat hippocampal astrocytes. | Noxious stimuli applied at doses close to but below the threshold of cell injury induce adaptive responses that provide a defense against additional stress. Epileptic preconditioning protects neurons against status epilepticus and ischemia; however, it is not known if the converse is true. During hypoxia/ischemia (H/I)... | 25,146,899 | [
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Inhibition of microbial adhesion to plastic surface and human buccal epithelial cells by Rhodomyrtus tomentosa leaf extract. | The adherence of oral pathogenic microorganisms to host tissues is the initial step for successful process of oral diseases. This study aimed to determine the effect of the Rhodomyrtus tomentosa leaf extract and rhodomyrtone, an antibacterial compound from R. tomentosa leaf, on adhesion of some oral pathogens to polyst... | 25,146,902 | [
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Proton conductive watery channels constructed by Anderson polyanions and lanthanide coordination cations. | A 3D inorganic-organic hybrid proton conductor, [Sm(H2O)5(CO2CH2NH3)2][Al(OH)6Mo6O18]·10H2O (), has been synthesized by using coordination cations, [Sm(H2O)5(gly)2](3+) (gly = (-)CO2CH2NH3(+)), and polyanions, [Al(OH)6Mo6O18](3-) ([AlMo6]). The polyanions ([AlMo6]) and the coordination cations ([Sm(H2O)5(gly)2](3+)) st... | 25,146,912 | [
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Ovarian hyperstimulation syndrome and thrombotic events. | Ovarian hyperstimulation syndrome (OHSS) is one of the most important complications of ovarian stimulation with severe morbidity and is still a threat to every patient undergoing ovulation induction. This manuscript reviews the current evidence regarding the relationship between OHSS and thromboembolism in infertile pa... | 25,146,913 | [
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Real-time imaging of endothelial cell-cell junctions during neutrophil transmigration under physiological flow. | During inflammation, leukocytes leave the circulation and cross the endothelium to fight invading pathogens in underlying tissues. This process is known as leukocyte transendothelial migration. Two routes for leukocytes to cross the endothelial monolayer have been described: the paracellular route, i.e., through the ce... | 25,146,919 | [
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HIV-1 Tat C modulates NOX2 and NOX4 expressions through miR-17 in a human microglial cell line. | HIV-1 invades CNS in the early course of infection, which can lead to the cascade of neuroinflammation. NADPH oxidases (NOXs) are the major producers of reactive oxygen species (ROS), which play important roles during pathogenic insults. The molecular mechanism of ROS generation via microRNA-mediated pathway in human m... | 25,146,963 | [
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Prevalence and Risk Factors for Overweight and Obesity among HIV-Infected Adults in Dar es Salaam, Tanzania. | Overweight and obesity are increasingly prevalent among HIV-infected populations. We describe their prevalence and associated risk factors among HIV-infected adults in Dar es Salaam, Tanzania. A cross-sectional study was conducted to determine the proportion of patients who were overweight or obese at enrollment to car... | 25,146,972 | [
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Prognostic value of multifocal electroretinography and optical coherence tomography in eyes undergoing panretinal photocoagulation for diabetic retinopathy. | To investigate the prognostic utility on visual acuity of multifocal electroretinography (mfERG) and optical coherence tomography (OCT) in diabetic eyes receiving panretinal photocoagulation (PRP). Patients with severe nonproliferative diabetic retinopathy (NPDR) or early proliferative diabetic retinopathy (PDR) who ne... | 25,146,984 | [
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High-resolution imaging of photoreceptors in macular microholes. | To assess photoreceptor structure in macular microholes by using adaptive optics scanning laser ophthalmoscopy (AO-SLO) and spectral-domain optical coherence tomography (SD-OCT) and compare with visual acuity. Fourteen eyes from 12 patients with macular microholes underwent a full ophthalmologic examination and imaging... | 25,146,990 | [
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Identifying functional co-activation patterns in neuroimaging studies via poisson graphical models. | Studying the interactions between different brain regions is essential to achieve a more complete understanding of brain function. In this article, we focus on identifying functional co-activation patterns and undirected functional networks in neuroimaging studies. We build a functional brain network, using a sparse co... | 25,147,001 | [
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Transplantation of tail skin to study allogeneic CD4 T cell responses in mice. | The study of T cell responses and their consequences during allo-antigen recognition requires a model that enables one to distinguish between donor and host T cells, to easily monitor the graft, and to adapt the system in order to answer different immunological questions. Medawar and colleagues established allogeneic t... | 25,147,005 | [
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Balneohydrotherapy in the treatment of chronic venous insufficiency. | Physical therapy has not been evaluated much for the treatment of chronic venous insufficiency before. The question is whether balneohydrotherapy and usual care combined is superior to usual care alone. In a randomized trial comparing spa therapy versus waiting list patients were treated on an out-patient basis in a pr... | 25,147,013 | [
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Lack of body positional effects on paresthesias when stimulating the dorsal root ganglion (DRG) in the treatment of chronic pain. | One prominent side effect from neurostimulation techniques, and in particular spinal cord stimulation (SCS), is the change in intensity of stimulation when moving from an upright (vertical) to a recumbent or supine (horizontal) position and vice versa. It is well understood that the effects of gravity combined with hig... | 25,147,020 | [
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Basic helix-loop-helix transcription factor BcbHLHpol functions as a positive regulator of pollen development in non-heading Chinese cabbage. | Cytoplasmic male sterility (CMS) is a common trait in higher plants, and several transcription factors regulate pollen development. Previously, we obtained a basic helix-loop-helix transcription factor, BcbHLHpol, via suppression subtractive hybridization in non-heading Chinese cabbage. However, the regulatory function... | 25,147,023 | [
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Quantum non-Markovianity: characterization, quantification and detection. | We present a comprehensive and up-to-date review of the concept of quantum non-Markovianity, a central theme in the theory of open quantum systems. We introduce the concept of a quantum Markovian process as a generalization of the classical definition of Markovianity via the so-called divisibility property and relate t... | 25,147,025 | [
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The oral microbiome diversity and its relation to human diseases. | As one of the most clinically relevant human habitats, the human mouth is colonized by a set of microorganisms, including bacteria, archaea, fungi, and viruses. Increasing evidence has supported that these microbiota contribute to the two commonest oral diseases of man (dental caries and periodontal diseases), presenti... | 25,147,055 | [
-0.2495209,
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0.4591381,
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0.2302645,
0.184265,
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0.1333957,
0.05058676,
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0.09574986,
0.3982909,
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Structure-activity relationship, biological, and pharmacological characterization of the proline sulfonamide ACT-462206: a potent, brain-penetrant dual orexin 1/orexin 2 receptor antagonist. | The orexin system consists of two G-protein-coupled receptors, the orexin 1 and orexin 2 receptors, widely expressed in diverse regions of the brain, and two peptide agonists, orexin A and orexin B, which are produced in a small assembly of neurons in the lateral hypothalamus. The orexin system plays an important role ... | 25,147,058 | [
0.1364226,
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0.2392964,
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Omega-3 fatty acid therapy dose-dependently and significantly decreased triglycerides and improved flow-mediated dilation, however, did not significantly improve insulin sensitivity in patients with hypertriglyceridemia. | Experimental studies demonstrate that higher intake of omega-3 fatty acids (n-3 FA) improves insulin sensitivity, however, we reported that n-3 FA 2g therapy, most commonly used dosage did not significantly improve insulin sensitivity despite reducing triglycerides by 21% in patients. Therefore, we investigated the eff... | 25,147,070 | [
0.1674669,
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0.1943942,
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0.3180452,
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0.2785075,
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0.1... |
Challenge of representing entropy at different levels of resolution in molecular simulation. | The role of entropic contributions in processes involving biomolecules is illustrated using the process of vaporization or condensation of the solvents water and methanol and the process of polypeptide folding in solution using molecular models at different levels of resolution: subatomic, atomic, supra-atomic, and sup... | 25,147,102 | [
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0.03245406,
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0.00204164,
0.1042088,
0.084537,
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... |
A theta-band EEG based index for early diagnosis of Alzheimer's disease. | Despite recent advances, early diagnosis of Alzheimer's disease (AD) from electroencephalography (EEG) remains a difficult task. In this paper, we offer an added measure through which such early diagnoses can potentially be improved. One feature that has been used for discriminative classification is changes in EEG syn... | 25,147,104 | [
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0.1128291,
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The pathophysiology of axonal transport in Alzheimer's disease. | Neurons communicate in the nervous system by carrying out information along the length of their axons to finally transmit it at the synapse. Proper function of axons and axon terminals relies on the transport of proteins, organelles, vesicles, and other elements from the site of synthesis in the cell body. Conversely, ... | 25,147,115 | [
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0.2631565,
0.1118008,
-0.00912679... |
Acetylcholinesterase biosensor based on multi-walled carbon nanotubes-SnO₂-chitosan nanocomposite. | A sensitive amperometric acetylcholinesterase (AChE) biosensor was developed based on the nanocomposite of multi-walled carbon nanotubes (MWCNTs), tin oxide (SnO2) nanoparticles and chitosan (CHIT). Acetylcholinesterase (AChE) and Nafion were immobilized onto the nanocomposite film to prepare AChE biosensor for pestici... | 25,147,124 | [
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0.4156337,
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Water with food intake does not influence caloric intake after gastric bypass (GBP): a cross-over trial. | Bariatric patients seeking information meet very different recommendations on postoperative diet and eating behaviour. A reason for variability may be lack of hard evidence. A national survey on current dietary advice was conducted to serve as background for the present study on how drinking during a meal influenced ca... | 25,147,125 | [
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-... |
Anonymization of DICOM electronic medical records for radiation therapy. | Electronic medical records (EMR) and treatment plans are used in research on patient outcomes and radiation effects. In many situations researchers must remove protected health information (PHI) from EMRs. The literature contains several studies describing the anonymization of generic Digital Imaging and Communication ... | 25,147,130 | [
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0.196665,
0.08517056,
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0.09616832,
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... |
An in silico case study of idiopathic dilated cardiomyopathy via a multi-scale model of the cardiovascular system. | Mathematical modelling has been used to comprehend the pathology and the assessment of different treatment techniques such as heart failure and left ventricular assist device therapy in the cardiovascular field. In this study, an in-silico model of the heart is developed to understand the effects of idiopathic dilated ... | 25,147,131 | [
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0.01075686,
0.3839831,
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... |
Synthesis and anticancer activity of (E)-2-benzothiazole hydrazones. | Benzothiazole hydrazones have been synthesized and evaluated for their in vitro antiproliferative activity against three human cancer cell lines: HL-60 (leukemia), MDAMB-435 (breast) and HCT-8 (colon). The good cytotoxicity for the three cancer cell lines and theoretical profile of compounds 3o and 3p pointed them as p... | 25,147,145 | [
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0.308504,
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... |
Sulfamates of methyl triterpenoates are effective and competitive inhibitors of carbonic anhydrase II. | Carbonic anhydrase II, belonging to one of the most important enzyme groups of the human body, is a well-studied isozyme from the family of the carbonic anhydrases. Since it is involved in several physiological processes, it has been a pharmaceutical target for many years. In this study we synthesized a number of sulfa... | 25,147,151 | [
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0.3702374,
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... |
Kaempferol, a potential cytostatic and cure for inflammatory disorders. | Kaempferol (3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) is a flavonoid found in many edible plants (e.g., tea, broccoli, cabbage, kale, beans, endive, leek, tomato, strawberries, and grapes) and in plants or botanical products commonly used in traditional medicine (e.g., Ginkgo biloba, Tilia spp, Equise... | 25,147,152 | [
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0.1565132,
-0.264587,... |
Off-label uses of alvimopan and methylnaltrexone. | Off-label uses of the peripheral μ-opioid receptor antagonists alvimopan and methylnaltrexone are reviewed. Alvimopan is approved by the Food and Drug Administration (FDA) for postoperative ileus after surgeries that include partial bowel resection with primary anastomosis, while methylnaltrexone is approved for the tr... | 25,147,168 | [
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Stability of ertapenem 100 mg/mL in polypropylene syringes stored at 25, 4, and -20 °C. | The stability of ertapenem solution in syringes at room, refrigerator, and freezer temperatures was determined to establish options for extended storage. Six replicate solutions of ertapenem (100 mg/mL) in 0.9% sodium chloride injection were prepared in 20-mL polypropylene syringes and stored at 25, 4, or -20 °C. Syrin... | 25,147,172 | [
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Implementation of standardized pediatric i.v. medication concentrations. | The development and implementation of a comprehensive and standardized list of pediatric i.v. medication concentrations across a large healthcare system are described. In accordance with National Patient Safety Goals, facilities affiliated with the Hospital Corporation of America system had independently standardized a... | 25,147,175 | [
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0.0... |
The sexual cascade and the rise of pre-ejaculatory (Darwinian) sexual selection, sex roles, and sexual conflict. | After brief historic overviews of sexual selection and sexual conflict, I argue that pre-ejaculatory sexual selection (the form of sexual selection discussed by Darwin) arose at a late stage in an inevitable succession of transitions flowing from the early evolution of syngamy to the evolution of copulation and sex rol... | 25,147,177 | [
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... |
Dual tasking with the timed "up & go" test improves detection of risk of falls in people with Parkinson disease. | Falls are a common and disabling feature of Parkinson disease (PD). Early identification of patients at greatest risk of falling is a key goal of physical therapy assessment. The Timed "Up & Go" Test (TUG), a frequently used mobility assessment tool, has moderate sensitivity and specificity for identifying fall ris... | 25,147,186 | [
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0.1557474,
-0.01... |
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