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The case of diagnostics of invasive pulmonary aspergillosis by in vivo probe-based confocal laser endomicroscopy of central and distal airways. | We present a case of 41-year-old patient with invasive pulmonary aspergillosis (IPA) in which probe-based confocal laser endomicroscopy (pCLE) imaging of central and distal airways was first performed in vivo. pCLE imaging showed the signs of complete or partial destruction of elastin network of alveolar wall with fibr... | 25,180,153 | [
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Pro-oxidant activity of indicaxanthin from Opuntia ficus indica modulates arachidonate metabolism and prostaglandin synthesis through lipid peroxide production in LPS-stimulated RAW 264.7 macrophages. | Macrophages come across active prostaglandin (PG) metabolism during inflammation, shunting early production of pro-inflammatory towards anti-inflammatory mediators terminating the process. This work for the first time provides evidence that a phytochemical may modulate the arachidonate (AA) metabolism in lipopolysaccha... | 25,180,166 | [
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Effect of hypoxia on the calcium and magnesium content, lipid peroxidation level, and Ca²⁺-ATPase activity of syncytiotrophoblast plasma membranes from placental explants. | In the current study the possible relationship between the Ca(2+)/Mg(2+) ratio of human syncytiotrophoblast plasma membranes and their lipid peroxidation and Ca(2+)-ATPase activity was determined. Syncytiotrophoblast plasma membranes of placental explants cultured under hypoxia increased their lipid peroxidation and Ca... | 25,180,187 | [
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A novel mutation in the transglutaminase-1 gene in an autosomal recessive congenital ichthyosis patient. | Structure-function implication on a novel homozygous Trp250/Gly mutation of transglutaminase-1 (TGM1) observed in a patient of autosomal recessive congenital ichthyosis is invoked from a bioinformatics analysis. Structural consequences of this mutation are hypothesized in comparison to homologous enzyme human factor XI... | 25,180,191 | [
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Invasive potential of melanoma cells correlates with the expression of MT1-MMP and regulated by modulating its association with motility receptors via N-glycosylation on the receptors. | Matrix remodeling and invasion of basement membrane are the major determinants of malignant progression. Matrix degrading enzymes play a pivotal role in this process and have been shown to be regulated at multiple levels. Using high metastatic B16F10 and its invasive variant B16BL6 cells, we previously demonstrated tha... | 25,180,193 | [
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Reconsideration at field scale of the relationship between hydraulic conductivity and porosity: the case of a sandy aquifer in South Italy. | To describe flow or transport phenomena in porous media, relations between aquifer hydraulic conductivity and effective porosity can prove useful, avoiding the need to perform expensive and time consuming measurements. The practical applications generally require the determination of this parameter at field scale, whil... | 25,180,202 | [
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A novel algorithm for imbalance data classification based on neighborhood hypergraph. | The classification problem for imbalance data is paid more attention to. So far, many significant methods are proposed and applied to many fields. But more efficient methods are needed still. Hypergraph may not be powerful enough to deal with the data in boundary region, although it is an efficient tool to knowledge di... | 25,180,211 | [
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Using SEM-EDX and ICP-OES to investigate the elemental composition of green macroalga Vaucheria sessilis. | The biomass of Vaucheria sessilis forms algal mats in many freshwaters. There is a need to find the method of algal biomass utilization. Vaucheria sessilis is a rich source of micro- and macronutrients and can be used as a soil amendment. In the paper, the elemental composition of enriched, via bioaccumulation process,... | 25,180,212 | [
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Avian influenza in Poland. | Poland has experienced four episodes of avian influenza (AI) outbreaks over the past two decades. The first epidemic was caused by a low pathogenicity (LPAIV) H7N7 subtype and occurred in fattening and breeder turkeys in 1995. Two waves of H5N1 high pathogenicity avian influenza (HPAI) took place in 2006 and 2007. In s... | 25,180,221 | [
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Introduction to molecular biology of influenza a viruses. | This minireview presents an overview of current knowledge on virion structure, genome organization and basic events in the development of influenza A virus. The processes of entry, transcription/replication and viral release are described. In this context, the roles of viral proteins (including recently discovered mino... | 25,180,226 | [
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Modification of fulleropyrazolines modulates their cleavage by light. | The extraordinary electrochemistry and the tunability of their energy levels allows the use of fulleropyrazolines in photovoltaics and charge-transfer systems. Here we show that substitution in position 1 tunes photolytic stability; electron-donating groups facilitate 1,3-dipolar cycloreversion to fullerene. This disco... | 25,180,246 | [
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Decoding calcium signaling across the nucleus. | Calcium (Ca(2+)) is an important multifaceted second messenger that regulates a wide range of cellular events. A Ca(2+)-signaling toolkit has been shown to exist in the nucleus and to be capable of generating and modulating nucleoplasmic Ca(2+) transients. Within the nucleus, Ca(2+) controls cellular events that are di... | 25,180,265 | [
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Graph analysis of functional brain networks: practical issues in translational neuroscience. | The brain can be regarded as a network: a connected system where nodes, or units, represent different specialized regions and links, or connections, represent communication pathways. From a functional perspective, communication is coded by temporal dependence between the activities of different brain areas. In the last... | 25,180,301 | [
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Perspective: network-guided pattern formation of neural dynamics. | The understanding of neural activity patterns is fundamentally linked to an understanding of how the brain's network architecture shapes dynamical processes. Established approaches rely mostly on deviations of a given network from certain classes of random graphs. Hypotheses about the supposed role of prominent topolog... | 25,180,302 | [
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From Caenorhabditis elegans to the human connectome: a specific modular organization increases metabolic, functional and developmental efficiency. | The connectome, or the entire connectivity of a neural system represented by a network, ranges across various scales from synaptic connections between individual neurons to fibre tract connections between brain regions. Although the modularity they commonly show has been extensively studied, it is unclear whether the c... | 25,180,307 | [
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Epigenetic engineering and the art of epigenetic manipulation. | A report on the Epigenetic Engineering Meeting hosted by the Barts Institute of Cancer, held in London, UK, May 7, 2014. | 25,180,340 | [
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Non-cavitated carious lesions detection methods: a systematic review. | The aim of this study was to critically appraise the performance of detection methods for non-cavitated carious lesions (NCCLs). A detailed search of Medline (via OVID), the Cochrane Collaboration, Scielo and EMBASE identified 2054 publications. After title and abstract review by three investigators (JG, MT, AI), 124 p... | 25,180,412 | [
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Precision high-throughput proton NMR spectroscopy of human urine, serum, and plasma for large-scale metabolic phenotyping. | Proton nuclear magnetic resonance (NMR)-based metabolic phenotyping of urine and blood plasma/serum samples provides important prognostic and diagnostic information and permits monitoring of disease progression in an objective manner. Much effort has been made in recent years to develop NMR instrumentation and technolo... | 25,180,432 | [
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The value of specialty pharmaceuticals - a systematic review. | Novel specialty biopharmaceuticals hold promise for patients living with complex and chronic conditions. However, high research and development costs, special handling, and other necessary enhancements to patient support programs all contribute to frequently higher prices for these products. This study sought to assess... | 25,180,434 | [
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Patient-centered medical home and quality measurement in small practices. | To assess performance on quality measures among small primary care practices that recently adopted an electronic health record (EHR), and how performance differs between practices that have achieved patient-centered medical home (PCMH) recognition and those that have not. Retrospective cohort study. Comparison of pract... | 25,180,435 | [
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Health insurance and breast-conserving surgery with radiation treatment. | To examine the impact of health insurance type on treatment of early-stage breast cancer using breast-conserving surgery (BCS) with radiation therapy (RT) among women in Florida and identify factors that contribute to the variations in receiving the treatment in women with the same health insurance type. Breast cancer ... | 25,180,437 | [
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Association of inflammatory response and oxidative injury in the pathogenesis of liver steatosis and insulin resistance following subchronic exposure to malathion in rats. | Insulin resistance and risk of type 2 diabetes are the most important complications following exposure to organophosphorous (OPs) pesticides. Regarding the importance of liver on metabolic pathways regulation, in particular blood glucose homeostasis, we focused on liver inflammation and oxidative damages in a subchroni... | 25,180,440 | [
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Rapid and efficient multiple healing of flexible conductive films by near-infrared light irradiation. | Healable, electrically conductive films are essential for the fabrication of reliable electronic devices to reduce their replacement and maintenance costs. Here we report the fabrication of near-infrared (NIR) light-enabled healable, highly electrically conductive films by depositing silver nanowires (AgNWs) on polycap... | 25,180,454 | [
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Long-term sexual functioning in women after surgical treatment of cervical cancer stages IA to IB: a prospective controlled study. | Women with cervical cancer (CC) may be faced with changes in sexual functioning resulting from the cancer itself and/or its surgical treatment. The aims of this study were to prospectively investigate sexual adjustment of CC patients during a follow-up period of 2 years after radical hysterectomy without adjuvant treat... | 25,180,463 | [
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Plasticity of human dental pulp stromal cells with bioengineering platforms: a versatile tool for regenerative medicine. | In recent years, human dental pulp stromal cells (DPSCs) have received growing attention due to their characteristics in common with other mesenchymal stem cells, in addition to the ease with which they can be harvested. In this study, we demonstrated that the isolation of DPSCs from third molar teeth of healthy indivi... | 25,180,486 | [
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Developing the evidence base for families living with parental psychiatric disabilities: crossing the bridge while we're building it. | For this special issue, the latest research findings on the topic of families living with parental psychiatric disabilities were solicited and compiled, to inform policymakers and practitioners with the best research available, while informing researchers about new developments in the field. The creative efforts of pra... | 25,180,526 | [
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Hearing-related, health-related quality of life in patients who have undergone otosclerosis surgery: a long-term follow-up study. | The aims of the study were to assess health-related quality of life and hearing-related disability in subjects with otosclerosis 30 years after surgery. An observational study was performed. Medical records were reviewed, a clinical examination as well as audiometric assessments were performed. Generic health-related q... | 25,180,536 | [
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Clark T. Sawin historical vignette: what do criminology, Harry Houdini, and King George V have in common with postpartum thyroid dysfunction? | The history of postpartum thyroid dysfunction (PPTD) dates back almost two millennia, when Soranus of Ephesus, who practiced obstetrics and neonatology, observed swelling in the necks (presumably goiters) of women after pregnancy. The next reference to PPTD appeared in artwork more than 1000 years later, with many port... | 25,180,618 | [
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ACR appropriateness Criteria® early-stage non-small-cell lung cancer. | Early-stage non-small-cell lung cancer (NSCLC) is diagnosed in about 15% to 20% of lung cancer patients at presentation. In order to provide clinicians with guidance in decision making for early-stage NSCLC patients, the American College of Radiology Appropriateness Criteria Lung Cancer Panel was recently charged with ... | 25,180,631 | [
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An interactive, all-payer, multidomain primary care performance dashboard. | Engaging physicians and practice leaders through regular performance reporting is a key goal of patient-centered medical home improvement efforts. We developed and implemented an interactive, Web-based performance dashboard for primary care practices with input from provider focus groups. Adapting a business software a... | 25,180,649 | [
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Androgen receptor polymorphisms and testicular cancer risk. | Testicular cancer (TC) is currently the most common malignant solid tumour in Caucasian males aged 15-39 years. Epidemiological evidence suggests that its onset may be due to an imbalance in the action of steroidal sex hormones and their receptors. A faulty androgen receptor signalling pathway can, in fact, cause vario... | 25,180,665 | [
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Aligned nanostructured polymers by magnetic-field-directed self-assembly of a polymerizable lyotropic mesophase. | Magnetic-field-directed assembly of lyotropic surfactant mesophases provides a scalable approach for the fabrication of aligned nanoporous polymers by templated polymerization. We develop and characterize a lyotropic liquid crystalline system containing hexagonally packed cylindrical micelles of a polymerizable surfact... | 25,180,677 | [
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Immune responses to ectoparasites of horses, with a focus on insect bite hypersensitivity. | Horses are affected by a wide variety of arthropod ectoparasites, ranging from lice which spend their entire life on the host, through ticks which feed over a period of days, to numerous biting insects that only transiently visit the host to feed. The presence of ectoparasites elicits a number of host responses includi... | 25,180,696 | [
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Evaluation of a continuing education course for occupational therapy practitioners on the use of applied behavior analysis. | A three hour continuing education course combining occupational therapy practice and behavior analysis strategies related to children with autism spectrum disorders was developed and delivered to 24 occupational therapy practitioners. Participants completed evaluations pre-course, post-course, and one month follow up o... | 25,180,710 | [
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The mRNAs associated to a zinc finger protein from Trypanosoma cruzi shift during stress conditions. | Trypanosome gene expression is regulated almost exclusively at the posttranscriptional level, through mRNA stability, storage and degradation. Here, we characterize the ribonucleoprotein complex (mRNPs) corresponding to the zinc finger protein TcZC3H39 from T. cruzi comparing cells growing in normal conditions and unde... | 25,180,711 | [
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Developing genetically engineered encapsulin protein cage nanoparticles as a targeted delivery nanoplatform. | Protein cage nanoparticles are excellent candidates for use as multifunctional delivery nanoplatforms because they are built from biomaterials and have a well-defined structure. A novel protein cage nanoparticle, encapsulin, isolated from thermophilic bacteria Thermotoga maritima, is prepared and developed as a versati... | 25,180,761 | [
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Secondary confessions: the influence (or lack thereof) of incentive size and scientific expert testimony on jurors' perceptions of informant testimony. | The goal of this research was to determine whether the size of the incentive (none, small, medium, or large, in terms of sentence reduction) a jailhouse informant receives for testifying, as well as scientific expert testimony regarding the fundamental attribution error, would influence mock juror decision-making in a ... | 25,180,762 | [
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Reduction of low- and high-grade cervical abnormalities associated with high uptake of the HPV bivalent vaccine in Scotland. | In Scotland, a national HPV immunisation programme began in 2008 for 12- to 13-year olds, with a catch-up campaign from 2008 to 2011 for those under the age of 18. To monitor the impact of HPV immunisation on cervical disease at the population level, a programme of national surveillance was established. We analysed col... | 25,180,766 | [
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Thinking aloud: effects on text comprehension by children with specific language impairment and their peers. | Many lines of evidence now suggest that inferencing plays a substantial role in text comprehension. However, inferencing appears to be difficult for children with language impairments, many of whom are also struggling readers. To assess the effects of a 'think-aloud' procedure on inference generation and narrative text... | 25,180,778 | [
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Nonrigid registration improves MRI T2 quantification in heart transplant patient follow-up. | To evaluate the use of a nonrigid registration technique for detecting acute heart transplant rejection by MRI T2 quantification. Myocardial T2 quantification was achieved in 279 consecutive examinations from 78 different patients. The protocol consisted of 10 successive black-blood fast spin echo sequences with varyin... | 25,180,788 | [
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Salvage lymph node dissection for nodal recurrence of prostate cancer after radical prostatectomy. | We analyzed the impact of salvage lymph node dissection on the prognosis in patients with biochemical recurrence and positive lymph nodes on positron emission tomography/computerized tomography after radical prostatectomy. We retrospectively analyzed the records of 58 patients who underwent pelvic and/or retroperitonea... | 25,180,792 | [
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Continuous variation rather than specialization in the egg phenotypes of cuckoos (Cuculus canorus) parasitizing two sympatric reed warbler species. | The evolution of brood parasitism has long attracted considerable attention among behavioural ecologists, especially in the common cuckoo system. Common cuckoos (Cuculus canorus) are obligatory brood parasites, laying eggs in nests of passerines and specializing on specific host species. Specialized races of cuckoos ar... | 25,180,796 | [
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Elusiveness of menstrual cycle effects on mate preferences: comment on Gildersleeve, Haselton, and Fales (2014). | This comment uses meta-analytic techniques to reconcile the apparent conflict between Gildersleeve, Haselton, and Fales's (2014) conclusion of "robust" effects of menstrual cycles on women's preferences for men of purported genetic quality and Wood, Kressel, Joshi, and Louie's (2014) assessment that the few, limited ef... | 25,180,804 | [
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Paraoxonase responses to exercise and niacin therapy in men with metabolic syndrome. | Our purpose was to characterize changes in paraoxonase 1 (PON1) activity and concentration after single aerobic exercise sessions conducted before and after 6 weeks of niacin therapy in men with metabolic syndrome (MetS). Twelve men with MetS expended 500 kcal by walking at 65% of VO2max before and after a 6-week regim... | 25,180,827 | [
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Genetic analyses of HIV-1 pol sequences from Zimbabwean patients. | This study analysed the sequence of HIV-1 pol gene derived from Zimbabwean infected patients. Sequence analysis, performed on 8 samples, revealed that sequences were classified as subtype C (n=5), subtype B (n=2) and CRF01_AE (n=1). Two patients, treated with a therapeutic regimen containing NRTI/NNRTI, harboured drug ... | 25,180,853 | [
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[Galectin-3 expression in peripheral blood mononuclear cells of chronic hepatitis B patients treated with pegylated interferon alpha-2a]. | To study the relationship between therapeutic efficacy of pegylated interferon alpha-2a (Peg-IFNa-2a) in patients with chronic hepatitis B (CHB) and expression of Galectin-3 in peripheral blood mononuclear cells (PBMCs). Fifty CHB patients treated with a 48-week course of Peg-IFNa-2a (180 mug/week, subcutaneous) were d... | 25,180,866 | [
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Meeting international standards: a cultural approach in implementing the mini-CEX effectively in Indonesian clerkships. | Abstract Background: Medical schools all over the world try to adapt their programs to meet international standards. However, local culture might hamper innovation attempts. To describe challenges in implementing the mini-CEX in Indonesia and investigate its effect on students' clinical competence. The study was conduc... | 25,180,877 | [
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Thirty years of illness scripts: Theoretical origins and practical applications. | This study describes the introduction and spread of the concept of "illness script" in the medical education literature. First, I will concisely discuss the development of the "script" concept in the general psychological literature and the results of the studies performed to provide it with the necessary empirical bas... | 25,180,878 | [
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Race and ethnic differences in early childhood maltreatment in the United States. | In the United States, over 6 million children were referred to child protective services in 2012. Black children are overrepresented among children investigated for child abuse and neglect. Understanding why black children are disproportionately reported for maltreatment is critical to informing policy and practice sol... | 25,180,892 | [
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Domestic and sexual violence against patients with severe mental illness. | Domestic and sexual violence are significant public health problems but little is known about the extent to which men and women with severe mental illness (SMI) are at risk compared with the general population. We aimed to compare the prevalence and impact of violence against SMI patients and the general population. Th... | 25,180,908 | [
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Engineering specificity in a dynamic protein complex with a single conserved mutation. | It has been demonstrated that the complex of yeast cytochrome c (Cc) and cytochrome c peroxidase (CcP) exists as a delicate equilibrium of a specific, active state and the non-specific, dynamic encounter state. An ortholog of yeast Cc, horse Cc, binds CcP but forms a much more dynamic complex, as demonstrated by NMR sp... | 25,180,929 | [
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Dissociable effects of dorsal and ventral hippocampal DHA content on spatial learning and anxiety-like behavior. | Chronic deficiency of dietary docosahexaenoic acid (DHA) during critical developmental windows results in severe deficits in spatial learning, anxiety and hippocampal neuroplasticity that parallel a variety of neuropsychiatric disorders. However, little is known regarding the influence of long-term, multigenerational e... | 25,180,934 | [
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Triamcinolone acetonide-Eudragit(®) RS100 nanofibers and nanobeads: Morphological and physicochemical characterization. | The aim of the present research was to fabricate triamcinolone acetonide (TA)-Eudragit(®) RS100 nanostructures using the electrospraying method. The physicochemical properties of the electrosprayed formulations as well as drug release patterns were assessed. The particle size and morphology were evaluated using scannin... | 25,180,944 | [
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Postabdominoplasty Wound Dehiscence in Bariatric Patients: Biliopancreatic Diversion Versus Gastric Bypass: A Preliminary Study. | Surgical procedures with an extended follow-up and therefore recognized as safe in literature are classified into 2 categories: procedures limiting the introduction of food mechanically (restrictive interventions such as adjustable gastric banding, vertical banded gastroplasty, and sleeve gastrectomy) or functionally (... | 25,180,957 | [
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The development and test re-test reliability of a work-related asthma screening questionnaire. | Work-related asthma (WRA) is under-recognized and delays in recognition contribute to long-term morbidity. The objective of the project was to develop a WRA screening questionnaire for use by primary care providers in the assessment of individuals with asthma, and to evaluate the respondent burden, test re-test reliabi... | 25,180,965 | [
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Atherosclerosis in intracranial, extracranial, and coronary arteries with aortic plaques in patients with ischemic stroke of undetermined etiology. | We investigated the association of cerebral and coronary artery atherosclerosis with the presence, burden and type of atherosclerotic plaques of the aorta (AP) in patients with ischemic stroke of undetermined etiology. 48 consecutive patients (32 males, mean age 68 ± 11 years) with acute ischemic stroke of unknown etio... | 25,180,988 | [
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[Diagnosis and treatment of rheumatoid arthritis]. | Rheumatoid arthritis today is still not curable but satisfactory treatable. Treatment targets include clinical remission (or at least low disease activity), lack of radiological destructions and functional disability as well as acceptable life quality and unimpaired working ability. Diagnosing and adequately treating t... | 25,180,998 | [
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Preserved modular network organization in the sedated rat brain. | Translation of resting-state functional connectivity (FC) magnetic resonance imaging (rs-fMRI) applications from human to rodents has experienced growing interest, and bears a great potential in pre-clinical imaging as it enables assessing non-invasively the topological organization of complex FC networks (FCNs) in rod... | 25,181,007 | [
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Confidence interval estimation for standardized effect sizes in multilevel and latent growth modeling. | Multilevel and latent growth models are frequently used interchangeably to examine differences between groups in trajectories of outcomes from controlled clinical trials. The unstandardized coefficient for the effect from group to slope (the treatment effect) from such models can be converted to a standardized mean dif... | 25,181,028 | [
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RPN2 Gene Confers Osteosarcoma Cell Malignant Phenotypes and Determines Clinical Prognosis. | Drug resistance and metastasis are lethal characteristics of tumors. We previously demonstrated that silencing of ribophorin II (RPN2), which is part of the N-oligosaccharyl transferase complex, efficiently induced apoptosis and reduced resistance to docetaxel in human breast cancer cells. Here, we report the clinical ... | 25,181,275 | [
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Investigating the intrinsic aggregation potential of evolutionarily conserved segments in p53. | Protein aggregation and amyloid formation are known to play a role both in diseases and in biological functions. Transcription factor p53 plays a major role in tumor suppression by maintaining genomic stability. Recent studies have suggested that amyloid formation of p53 could lead to its loss of physiological function... | 25,181,279 | [
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Best practices for mapping replication origins in eukaryotic chromosomes. | Understanding the regulatory principles ensuring complete DNA replication in each cell division is critical for deciphering the mechanisms that maintain genomic stability. Recent advances in genome sequencing technology facilitated complete mapping of DNA replication sites and helped move the field from observing repli... | 25,181,303 | [
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Transient hypermutagenesis accelerates the evolution of legume endosymbionts following horizontal gene transfer. | Horizontal gene transfer (HGT) is an important mode of adaptation and diversification of prokaryotes and eukaryotes and a major event underlying the emergence of bacterial pathogens and mutualists. Yet it remains unclear how complex phenotypic traits such as the ability to fix nitrogen with legumes have successfully sp... | 25,181,317 | [
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Fast adsorption of Cd²⁺ and Pb²⁺ by EGTA dianhydride (EGTAD) modified ramie fiber. | In this study, the removal of Cd(2+) and Pb(2+) from aqueous solutions was investigated using a novel chelating material. The first part described the synthesis of ethylene glycol-bis(2-aminoethylether)-N,N,N',N'-tetraacetic acid dianhydride (EGTAD), mercerization treatment of ramie fiber (MRF), and the MRF was then re... | 25,181,330 | [
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Total inhibition of (1)O2-induced oxidative damage to guanine bases of DNA/RNA by turmeric extracts. | The guanine base of nucleic acids is known to be very reactive towards degradation by (1)O2-induced oxidative stress. Oxidative reactions of DNA are linked to many human diseases including cancer. Among the various forms of reactive O2 species (OH, (1)O2 or O2(-)), the oxidative stress caused by (1)O2 is of particular ... | 25,181,345 | [
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Who reports it best? A comparison between parent-report, self-report, and the real life social behaviors of adults with Williams syndrome. | Given the reliance on self-report in studies of adults with intellectual disabilities, this study examined individual vs. parental reports concerning the social approach behaviors of adults with Williams syndrome (WS) across a hypothetical and a live behavioral setting. Individuals with WS (N = 30) were asked whether t... | 25,181,359 | [
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Stratification of patients with liver fibrosis using dual-energy CT. | Assessing the severity of liver fibrosis has direct clinical implications for patient diagnosis and treatment. Liver biopsy, typically considered the gold standard, has limited clinical utility due to its invasiveness. Therefore, several imaging-based techniques for staging liver fibrosis have emerged, such as magnetic... | 25,181,365 | [
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The shape of the scene background determines the perceived path of a moving object. | Studies of the perception of motion in three-dimensional scenes have provided extensive information about the effects of changes in the size, speed, and disparity of an object's image on the perception of the object's trajectory. The present study demonstrates that this perception is not determined primarily by the obj... | 25,181,369 | [
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Committee opinion: onabotulinumtoxinA and the bladder. | In January 2013, the US Food and Drug Administration approved the use of onabotulinumtoxinA (also known as Botox A) for the treatment of overactive bladder, thus providing another treatment option for women. Symptoms of overactive bladder have been shown to significantly improve after onabotulinumtoxinA injections comp... | 25,181,372 | [
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Validation of genetically matched wild-type strain and lysyl oxidase-like 1 knockout mouse model of pelvic organ prolapse. | Lysyl oxidase-like 1 knockout (Loxl1) mice demonstrate deficient elastin homeostasis associated with pelvic organ prolapse (POP). To further investigate the pathophysiology of POP in these animals, a genetically matched homozygous positive (Loxl1) or wild-type strain is needed. This study sought to create and validate ... | 25,181,380 | [
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The neuropsychological assessment battery categories test as a measure of executive dysfunction in patients with Parkinson's disease and essential tremor: an exploratory study. | Patients with Parkinson's disease (PD) and essential tremor (ET) can experience deficits in executive functioning (EF) secondary to abnormalities in fronto-striatal and cerebellar-frontal pathways respectively. The assessment of EF can be confounded in these patients due to motor difficulties and slowed processing spee... | 25,181,389 | [
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Weakening of the stratospheric polar vortex by Arctic sea-ice loss. | Successive cold winters of severely low temperatures in recent years have had critical social and economic impacts on the mid-latitude continents in the Northern Hemisphere. Although these cold winters are thought to be partly driven by dramatic losses of Arctic sea-ice, the mechanism that links sea-ice loss to cold wi... | 25,181,390 | [
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Developing content for a mHealth intervention to promote postpartum retention in prevention of mother-to-child HIV transmission programs and early infant diagnosis of HIV: a qualitative study. | Maternal attendance at postnatal clinic visits and timely diagnosis of infant HIV infection are important steps for prevention of mother-to-child transmission (PMTCT) of HIV. We aimed to use theory-informed methods to develop text messages targeted at facilitating these steps. We conducted five focus group discussions ... | 25,181,408 | [
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Osteoprotegerin, fibroblast growth factor 23, and vitamin D3 levels in male patients with hypogonadism. | Cardiometabolic disorders and osteoporosis are prevalent in patients with hypogonadism. Osteoprotegerin (OPG) and fibroblast growth factor-23 (FGF-23), are co-secreted from bones and vascular endothelium, regulating bone mineral metabolism and vascular functions. Vitamin D is another hormone with dual effects on bone a... | 25,181,418 | [
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Molecular analysis for screening human bacterial pathogens in municipal wastewater treatment and reuse. | Effective and sensitive monitoring of human pathogenic bacteria in municipal wastewater treatment is important not only for managing public health risk related to treated wastewater reuse, but also for ensuring proper functioning of the treatment plant. In this study, three different 16S rRNA gene molecular analysis me... | 25,181,426 | [
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Roles of estrogen in the formation of intracranial aneurysms in ovariectomized female mice. | Epidemiological studies have indicated that postmenopausal women have a higher incidence of intracranial aneurysms than men in the same age group. To investigate whether estrogen or estrogen receptors (ERs) mediate protective effects against the formation of intracranial aneurysms. Intracranial aneurysms were induced i... | 25,181,430 | [
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Persistent differences in mortality patterns across industrialized countries. | The epidemiological transition has provided the theoretical background for the expectation of convergence in mortality patterns. We formally test and reject the convergence hypothesis for a sample of industrialized countries in the period from 1960 to 2008. After a period of convergence in the decade of 1960 there foll... | 25,181,447 | [
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The effect of social support on the health of Indigenous Australians in a metropolitan community. | The factors driving the disparity in health outcomes between Indigenous and non-Indigenous Australians continue to be poorly understood. Despite this, studies confirm that social connections are a very important part of Indigenous life, and it is likely these connections play an important role in influencing health out... | 25,181,473 | [
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mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways. | Stimulation of type I metabotropic glutamate receptors (mGluR1/5) in several neuronal types induces slow excitatory responses through activation of transient receptor potential canonical (TRPC) channels. GABAergic cerebellar molecular layer interneurons (MLIs) modulate firing patterns of Purkinje cells (PCs), which pla... | 25,181,481 | [
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Regular breakfast consumption and type 2 diabetes risk markers in 9- to 10-year-old children in the child heart and health study in England (CHASE): a cross-sectional analysis. | Regular breakfast consumption may protect against type 2 diabetes risk in adults but little is known about its influence on type 2 diabetes risk markers in children. We investigated the associations between breakfast consumption (frequency and content) and risk markers for type 2 diabetes (particularly insulin resistan... | 25,181,492 | [
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Divided attention can enhance early-phase memory encoding: the attentional boost effect and study trial duration. | Divided attention during encoding typically produces marked reductions in later memory. The attentional boost effect (ABE) is a surprising variation on this phenomenon. In this paradigm, each study stimulus (e.g., a word) is presented along with a target or a distractor (e.g., different colored circles) in a detection ... | 25,181,494 | [
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Comparison of Segmental Colon Transit Time With Total Energy Expenditure in Psychiatry Unit Patients. | Physical activity is associated with a reduced risk of colorectal cancer. We examined the colon transit time (CTT) according to the total energy expenditure (TEE) in psychiatry unit patients. The study participants included 67 adults, with a mean age of 49.8 years. The participants used an accelerometer for 7 days to m... | 25,181,498 | [
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Synthesis of non-linear protein dimers through a genetically encoded Thiol-ene reaction. | Site-specific incorporation of bioorthogonal unnatural amino acids into proteins provides a useful tool for the installation of specific functionalities that will allow for the labeling of proteins with virtually any probe. We demonstrate the genetic encoding of a set of alkene lysines using the orthogonal PylRS/PylTCU... | 25,181,502 | [
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... |
Adverse outcomes of anticoagulant use among hospitalized patients with chronic kidney disease: a comparison of the rates of major bleeding events between unfractionated heparin and enoxaparin. | Anticoagulation therapy is usually required in patients with chronic kidney disease (CKD) for treatment or prevention of thromboembolic diseases. However, this benefit could easily be offset by the risk of bleeding. To determine the incidence of adverse outcomes of anticoagulants in hospitalized patients with CKD, and ... | 25,181,525 | [
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Recombinant antibody color resulting from advanced glycation end product modifications. | Recombinant antibodies produced in Chinese hamster ovary (CHO) cells often exhibit a slight yellow-brown color, but the molecular basis for this color has remained elusive. We predicted that the color results from post-translational modifications on the antibody, because colored species were found to coelute with antib... | 25,181,536 | [
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Two-compartmental population balance modeling of a pulsed spray fluidized bed granulation based on computational fluid dynamics (CFD) analysis. | In this work a two-compartmental population balance model (TCPBM) was proposed to model a pulsed top-spray fluidized bed granulation. The proposed TCPBM considered the spatially heterogeneous granulation mechanisms of the granule growth by dividing the granulator into two perfectly mixed zones of the wetting compartmen... | 25,181,553 | [
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Polyaromatic hydrocarbons do not disturb liquid-liquid phase coexistence, but increase the fluidity of model membranes. | Polyaromatic hydrocarbons (PAHs) is a group of compounds, many of which are toxic, formed by incomplete combustion or thermal processing of organic material. They are highly lipophilic and thus present in some seed oils used for human consumption as well as being increasingly common in aquaculture diets due to inclusio... | 25,181,555 | [
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The reliability of a VISION COACH task as a measure of psychomotor skills. | The VISION COACH™ interactive light board is designed to test and enhance participants' psychomotor skills. The primary goal of this study was to examine the test-retest reliability of the Full Field 120 VISION COACH task. One hundred eleven male and 131 female adult participants completed six trials where they respond... | 25,181,563 | [
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Efficient synthesis of ABAB functionalized phthalocyanines. | ABAB-type Zn(II) phthalocyanines, crosswise-functionalized with two and four iodine atoms, respectively, have been efficiently prepared using statistical condensation procedures. Key to the selective preparation of the opposite ABAB isomers versus the adjacent AABB ones is the use of bulky 3,6-(3',5'-bis(trifluoromethy... | 25,181,582 | [
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Sensorimotor trigeminal unbalance modulates pupil size. | We studied whether patients affected by Temporo-Mandibular Disorder (TMD), showing asymmetric electromyographic (EMG) activity of masticatory muscles also display asymmetries in pupil size. In 30 pain free TMD patients a highly significant, positive correlation was found between left-right differences in EMG and pupil ... | 25,181,592 | [
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Optimization of ethanol production from microfluidized wheat straw by response surface methodology. | In this study, wheat straw was pretreated with a microfluidizer to improve its enzymatic hydrolysis and ethanol yields. The pretreatment was performed at various pressures (500, 1000, and 1500 bar) and solid loadings (1, 2, and 3%). The microfluidized biomass was then subjected to hydrolysis and simultaneous saccharifi... | 25,181,638 | [
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Transoral robotic surgery and oropharyngeal cancer: a literature review. | The incidence of head and neck squamous cell carcinoma has risen steadily over the past decade due to the increase in cancers associated with the human papillomavirus (HPV). The prognosis for the treatment of this type of cancer with radiotherapy and chemoradiotherapy is good. However, because these treatments can have... | 25,181,669 | [
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Primary diffuse large B-cell lymphoma of the ethmoid sinus: a case report. | B-cell lymphoma of the paranasal sinuses is rare. We present the case of a 42-year-old woman who presented with proptosis, diplopia, and vision disturbances in the right eye. She was diagnosed with diffuse large B-cell lymphoma of the ethmoid sinus. We describe the general clinical presentation, diagnosis, and differen... | 25,181,675 | [
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β-Aryl-α-nitro-α,β-enals as heterodienes and dienophiles. | As demonstrated with the β-(2-furyl)-substituted analogue 1b, β-aryl-α-nitro-α,β-enals (1) behave as heterodienes against enamines and enol ethers using their enal unit (e.g., 1b → 12). α-Nitro-α,β-enals can act as well as highly reactive dienophiles to render adducts endowed with nitrogenated quaternary centers (e.g.,... | 25,181,678 | [
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Addressing health disparities: Brown University School of Public Health. | Health disparities are a public health concern in Rhode Island and around the world. Faculty members and students in the Brown University School of Public Health are working to understand, address, and ultimately eliminate disparities in health and health care affecting diverse populations. Our educational offerings an... | 25,181,746 | [
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Transport of graphene oxide nanoparticles in saturated sandy soil. | We examined the transport properties of graphene oxide nanoparticles (GONPs) in saturated sandy soil, under different solution chemistry conditions and flow velocities. GONPs exhibited high mobility in soil, even at 50 mM NaCl. While at relatively high ionic strength GONPs were less mobile in soil than in quartz sand, ... | 25,181,756 | [
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Conducted electrical weapons within healthcare: a comprehensive use of force model. | Healthcare settings are experiencing increased amounts of violent activity that are challenging to the health care security profession. There is difficulty in addressing this issue completely. Some of this difficulty is because of factors that include inexperienced and untrained clinicians and administrators that are o... | 25,181,791 | [
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How the millennial generation is transforming employee benefits. | According to a number of recent studies, the millennial generation, today's incoming young-adult employees, shows far more interest than older generations in a broad spectrum of employee bene its to protect them from various life risks. They are more cautious than boomers or Gen Xers in choosing their financial portfol... | 25,181,813 | [
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Requiring work during FMLA. Vess v. Scott Medical Corp., 2013 WL 1100068 (N.D.Ohio 2013). | Calls regarding job responsibilities were permissible; allegedly requiring supervisor to complete educational competencies before returning to work, complete evaluations of respiratory therapists and enter blood gas data was not. | 25,181,819 | [
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Melanoma risk prediction models. | The lack of effective therapy for advanced stages of melanoma emphasizes the importance of preventive measures and screenings of population at risk. Identifying individuals at high risk should allow targeted screenings and follow-up involving those who would benefit most. The aim of this study was to identify most sign... | 25,181,836 | [
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