title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Adaptive maternal immune deviations as a ground for autism spectrum disorders development in children. | Autism is a vexed problem today. Overall, there is a high frequency of birth children (1:80 - 1:150) with late diagnosed autism spectrum disorders (ASD) and this trend is getting progressively stronger. The causes for the currently increased frequency of ASD and the pathogenesis of ASD are not fully understood yet. One... | 25,181,843 | [
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Paroxysmal atrial fibrillation: dynamics of the main antioxidant enzymes--superoxide dismutase and catalase. | Researchers have a particularly strong interest in the mechanisms implicated in the clinical manifestation of atrial fibrillation. To examine dynamically the activity of the antioxidant enzymes, superoxide dismutase and catalase in patients with paroxysmal atrial fibrillation (duration < 48 hours). The studied param... | 25,181,846 | [
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A case of TRAP sequence with immense acardiac twin. | Twin-reversed arterial perfusion sequence is a rare complication of monochorionic twin pregnancy in which an anomalous acardiac fetus is hemodynamically dependent on its structurally normal "pump" twin. Early diagnosis is essential for improving perinatal prognosis for the normal twin. In this case report we present a ... | 25,181,851 | [
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An old friend you've never met. | For 36 years, Simon Lillie has stood watch at Methodist Hospitals in Gary, Ind. The affable 64-year-old is never reluctant to extend a welcoming hand or lend an ear. | 25,181,908 | [
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Effects of supervised exercise on motivational outcomes in breast cancer survivors at 5-year follow-up. | Short-term physical activity (PA) has beneficial effects on symptom management and quality of life, however, longer-term adherence is likely needed for improved disease outcomes in breast cancer survivors (BCS). This study examined the effects of a supervised group exercise program on motivational outcomes and PA among... | 25,181,937 | [
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Flocking at a distance in active granular matter. | The self-organized motion of vast numbers of creatures in a single direction is a spectacular example of emergent order. Here, we recreate this phenomenon using actuated nonliving components. We report here that millimetre-sized tapered rods, rendered motile by contact with an underlying vibrated surface and interactin... | 25,181,961 | [
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Virtual screening for novel Staphylococcus Aureus NorA efflux pump inhibitors from natural products. | NorA is a member of the Major Facilitator Superfamily (MFS) drug efflux pumps that have been shown to mediate antibiotic resistance in Staphylococcus aureus (SA). In this study, QSAR analysis, virtual screening and molecular docking were implemented in an effort to discover novel SA NorA efflux pump inhibitors. Origina... | 25,181,985 | [
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Professional care providers in dementia care in eight European countries; their training and involvement in early dementia stage and in home care. | Knowledge concerning professionals involved in dementia care throughout its trajectory is sparse; the focus has mainly been on nursing-home care and less on home care, diagnosis and treatment of the disease and its complications despite the fact that home care is the most prominent type of care. The aim of this study w... | 25,181,988 | [
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Experiential or behavioral processes: which one is prominent in physical activity? Examining the processes of change 1 year after an intervention of therapeutic education among adults with obesity. | Although physical activity (PA) is essential, most obese people will not engage in its practice. The transtheoretical model (TTM) and its processes of change (POC) contribute to the understanding of behavior change regarding PA. The present study aimed to test how POC are associated with a progression through the stage... | 25,181,999 | [
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Quantitative determination of cellular farnesyltransferase activity: towards defining the minimum substrate reactivity for biologically relevant protein farnesylation. | Prenylation is a post-translational modification wherein an isoprenoid group is attached to a protein substrate by a protein prenyltransferase. Hundreds of peptide sequences are in vitro substrates for protein farnesyltransferase (FTase), but it remains unknown which of these sequences can successfully compete for in v... | 25,182,009 | [
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Sevoflurane preconditioning-induced neuroprotection is associated with Akt activation via carboxy-terminal modulator protein inhibition. | Sevoflurane preconditioning has a neuroprotective effect, but the underlying mechanism is not fully understood. The aim of the present investigation was to evaluate whether sevoflurane-induced cerebral preconditioning involves inhibition of carboxy-terminal modulator protein (CTMP), an endogenous inhibitor of Akt, in a ... | 25,182,017 | [
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Cow's milk allergy and neonatal short bowel syndrome: comorbidity or true association? | Neonatal short bowel syndrome (SBS) follows early intestinal resections that may expose the children to increased intestinal contact with undigested food proteins and to the risk of food allergy. We report three consecutive cases of cow's milk allergy (CMA) in SBS infants. We reviewed three cases of CMA developed in 37... | 25,182,018 | [
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Role of the new rural cooperative medical system in alleviating catastrophic medical payments for hypertension, stroke and coronary heart disease in poor rural areas of China. | Hypertension, stroke and coronary heart disease (CHD) are common diseases that impose a heavy burden on patients and their families, particularly on those living in poor areas. This study examined catastrophic medical payments faced by patients with these diseases and the effectiveness of the new rural cooperative medi... | 25,182,027 | [
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Influence of real-world characteristics on outcomes for patients with methicillin-resistant Staphylococcal skin and soft tissue infections: a multi-country medical chart review in Europe. | Patient-related (demographic/disease) and treatment-related (drug/clinician/hospital) characteristics were evaluated as potential predictors of healthcare resource use and opportunities for early switch (ES) from intravenous (IV)-to-oral methicillin-resistant Staphylococcus aureus (MRSA)-active antibiotic therapy and e... | 25,182,029 | [
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Pharmacokinetic/pharmacodynamic evaluation of linezolid in hospitalized paediatric patients: a step toward dose optimization by means of therapeutic drug monitoring and Monte Carlo simulation. | To report on linezolid exposure in a paediatric population who routinely underwent therapeutic drug monitoring (TDM) for dosage optimization and to assess the factors affecting interpatient variability. We performed a retrospective study of patients whose plasma C(min) and Cmax levels were measured during linezolid tre... | 25,182,066 | [
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A smartphone controlled handheld microfluidic liquid handling system. | Microfluidics and lab-on-a-chip technologies have made it possible to manipulate small volume liquids with unprecedented resolution, automation and integration. However, most current microfluidic systems still rely on bulky off-chip infrastructures such as compressed pressure sources, syringe pumps and computers to ach... | 25,182,078 | [
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The Inferior Alveolar Nerve of the Horse: Course and Anatomical Relationship with Mandibular Cheek Teeth. | The precise location of neurovascular structures within the relatively long mandibular canal of the horse is of paramount importance in surgical procedures of the area. The inferior alveolar nerve (IAN) enters the mandibular canal on the medial (lingual) surface of the mandible and innervates all the mandibular teeth. ... | 25,182,080 | [
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Long-term follow-up after bariatric surgery: a systematic review. | Bariatric surgery is an accepted treatment for obesity. Despite extensive literature, few studies report long-term follow-up in cohorts with adequate retention rates. To assess the quality of evidence and treatment effectiveness 2 years after bariatric procedures for weight loss, type 2 diabetes, hypertension, and hype... | 25,182,102 | [
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Thermal gelation of chitosan in an aqueous alkali-urea solution. | Chitosan can readily dissolve in a precooled aqueous alkali-urea solution, a solvent that has previously been developed to dissolve cellulose. Upon heating, the resulting solutions quickly become a gel. The thermal gelling of the chitosan solutions was studied by rheology. Initially, a temperature ramp test was used to... | 25,182,118 | [
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The expanding spectrum of PRPS1-associated phenotypes: three novel mutations segregating with X-linked hearing loss and mild peripheral neuropathy. | Next-generation sequencing is currently the technology of choice for gene/mutation discovery in genetically-heterogeneous disorders, such as inherited sensorineural hearing loss (HL). Whole-exome sequencing of a single Italian proband affected by non-syndromic HL identified a novel missense variant within the PRPS1 gen... | 25,182,139 | [
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A mid-morning snack of almonds generates satiety and appropriate adjustment of subsequent food intake in healthy women. | To assess the effect of consuming a mid-morning almond snack (28 and 42 g) tested against a negative control of no almonds on acute satiety responses. On three test days, 32 healthy females consumed a standard breakfast followed by 0, 28 or 42 g of almonds as a mid-morning snack and then ad libitum meals at lunch and d... | 25,182,142 | [
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Treating severe hypoglycemia: rapid mixing of lyophilized glucagon and diluent at point of care with the Enject GlucaPen. | Severe hypoglycemia (SH) is a common problem in type 1 diabetes (T1D). Annually, nearly 1 of 5 persons with long-standing T1D will have SH. Though injections of glucagon are effective in treating SH, liquid formulations of glucagon are biochemically very unstable. For this reason, available preparations of glucagon are... | 25,182,147 | [
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Efficacy of β-sitosterol isolated from Evolvulus alsinoides L. as anti-hyperlipidemic and anti-tumor agent: Evidence from animal studies. | To explore the anti-hyperlipidemic and anti-tumor effect of ethanolic extract of Evolvulus alsinoides, its chloroform fraction and isolated components in Triton-induced hyperlipidemic rats. Animals were administered with intraperitoneal (i.p.) injection of Triton WR 1339 at a dose of 400 mg/kg body weight. After 24 h o... | 25,182,155 | [
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Prevalence of vascular disease in systemic lupus erythematosus compared with type-1 diabetes mellitus: a cross-sectional study of two cohorts. | Systemic lupus erythematosus (SLE) is associated with considerable cardiovascular morbidity that has not yet been directly compared with other diseases with known cardiovascular risk. Two hundred and forty-one patients of the multicentre Swiss SLE cohort study (SSCS) were cross-sectionally assessed for coronary heart d... | 25,182,169 | [
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Distant peer-tutoring of clinical skills, using tablets with instructional videos and Skype: A pilot study in the UK and Malaysia. | To assess the feasibility and impact of using low-cost Android tablets to deliver video tutorials and remote online peer-tutoring for clinical skills between two countries. Nine junior medical students from Malaysia were paired with five senior medical students from the UK, who played the role of peer-tutors. Students ... | 25,182,187 | [
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The overdue promise of short tandem repeat variation for heritability. | Short tandem repeat (STR) variation has been proposed as a major explanatory factor in the heritability of complex traits in humans and model organisms. However, we still struggle to incorporate STR variation into genotype-phenotype maps. We review here the promise of STRs in contributing to complex trait heritability ... | 25,182,195 | [
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Quantitative measurement of brain iron deposition in patients with haemodialysis using susceptibility mapping. | To compare the susceptibility of different brain structures in patients with haemodialysis with that in healthy controls using susceptibility mapping and explore the correlations with neuropsychiatric tests and clinical parameters. Fifty three patients with haemodialysis and forty-five age-and sex-matched healthy contr... | 25,182,196 | [
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Reviews and prospectives of signaling pathway analysis in idiopathic pulmonary fibrosis. | Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing disease with disappointing survival rate, and uneffective therapeutic progress has been made in the last few years, forcing the urgent need to improve research to this disease. The commonly accepted pathogenic hypothesis of IPF is the trigger from continuou... | 25,182,202 | [
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Four dermatomyositis-specific autoantibodies-anti-TIF1γ, anti-NXP2, anti-SAE and anti-MDA5-in adult and juvenile patients with idiopathic inflammatory myopathies in a Hungarian cohort. | Idiopathic inflammatory myopathies (IIMs) are chronic systemic autoimmune diseases characterised by symmetrical, proximal muscle weakness. Dermatomyositis represents one subset of IIMs, in which skin rashes are present in addition to muscle weakness. Myositis-specific antibodies can only be detected in myositis, and th... | 25,182,203 | [
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Systemic sclerosis evolution of disease pathomorphosis and survival. Our experience on Italian patients' population and review of the literature. | The clinical spectrum and prognosis of systemic sclerosis (SSc) seem to vary among patients' populations recruited during different time periods. In order to verify this possible evolution we investigated the clinico-serological and survival rate in a large Italian SSc series (821 patients; 746 females, 75 males; mean ... | 25,182,204 | [
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Identification of a novel myositis-associated antibody directed against cortactin. | The aim of this study is to describe a novel myositis-associated autoantibody (anti-cortactin antibody) and assess related clinical and immunological manifestations and its clinical significance. Adult patients with myositis (dermatomyositis, polymyositis, immune-mediated necrotizing myopathy, and inclusion body myosit... | 25,182,205 | [
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Rivaroxaban vs. vitamin K antagonists for cardioversion in atrial fibrillation. | X-VeRT is the first prospective randomized trial of a novel oral anticoagulant in patients with atrial fibrillation undergoing elective cardioversion. We assigned 1504 patients to rivaroxaban (20 mg once daily, 15 mg if creatinine clearance was between 30 and 49 mL/min) or dose-adjusted vitamin K antagonists (VKAs) in ... | 25,182,247 | [
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MRI - what important findings can it show in children with back pain? | The percentage of school-age children who have already had an episode of back pain can be as high as 51%, and the incidence of the disease increases with age and physical activity. This paper summarizes the MR examinations of children with back pain carried out at the Institute of Mother and Child in Warsaw and highlig... | 25,182,257 | [
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Pancreatic islet regeneration and some liver biochemical parameters of leaf extracts of Vitex doniana in normal and streptozotocin-induced diabetic albino rats. | To test two water soluble extracts (aqueous and ethanolic) obtained from the leaves of Vitex doniana in normal and streptozotocin-induced diabetic rats for their effects on pancreatic endocrine tissues and serum marker enzymes for a period of 21 d. A total of 55 rats divided into 11 groups of 5 rats each were assigned ... | 25,182,283 | [
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Ameliorative effect of alkaloid extract of Cyclea peltata (Poir.) Hook. f. & Thoms. roots (ACP) on APAP/CCl4 induced liver toxicity in Wistar rats and in vitro free radical scavenging property. | To evaluate the hepatoprotective and antioxidant properties of alkaloid extract of Cyclea peltata (C. peltata) against paracetamol/carbon tetra chloride induced liver damage in Wistar rats. In vivo paracetamol/carbon tetrachloride induced liver damage in Wistar rats, in vitro free radical scavenging studies, HPTLC esti... | 25,182,286 | [
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Prevalence and antibiogram of bacterial isolates from urinary tract infections at Dessie Health Research Laboratory, Ethiopia. | To determine the prevalence and antimicrobial susceptibility of bacteria from suspected urinary tract infections. A retrospective analysis of bacterial pathogens and their antimicrobial susceptibility was done on urine samples at Dessie Regional Laboratory in the period 2003 to 2010. Antimicrobial susceptibility tests ... | 25,182,289 | [
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Peripheral blood mononuclear cell-based metabolomic profiling of a chronic unpredictable mild stress rat model of depression. | Major depressive disorder (MDD) is a debilitating mood disorder with various etiopathological hypotheses. However the pathogenesis and diagnosis are still unclear. Peripheral blood mononuclear cells (PBMCs) have been shown to be well-suited to biomarker investigation in major depressive disorder (MDD), as well as to un... | 25,182,291 | [
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A composite cathode based on scandium doped titanate with enhanced electrocatalytic activity towards direct carbon dioxide electrolysis. | A composite cathode based on redox-stable La0.2Sr0.8TiO(3+δ) (LSTO) can perform direct carbon dioxide electrolysis; however, the insufficient electro-catalytic activity limits the electrode performances and current efficiencies. In this work, catalytically active scandium is doped into LSTO to enhance the electro-catal... | 25,182,301 | [
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Sublingual immunotherapy: current concepts for the U.S. practitioner. | Estimates of the prevalence of allergic rhinitis in the United States range from 20% to 40%. Allergen-specific immunotherapy (SIT) is typically recommended for patients with allergic rhinitis who fail medical treatment, desire an alternative to pharmacotherapy, or would like to pursue therapy that can potentially chang... | 25,182,357 | [
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Practical clinical approaches to the allergic rhinitis patient. | Numerous treatment strategies are available for the treatment of allergic rhinitis (AR), including environmental controls, pharmacotherapy, immunotherapy, and surgery in appropriately selected patients. A stepwise algorithmic approach based on disease severity and persistence of symptoms is often advocated to effective... | 25,182,359 | [
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Asthma and the otolaryngologist. | Asthma is a chronic inflammatory disease of the lower airway that is commonly encountered by the otolaryngologist. This article provides information on how to recognize patients with asthma and discuss issues related to diagnosis, treatment, and continued management within the context of current guidelines. A literatur... | 25,182,360 | [
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The feelings of adolescents connected with medical visits and their perception of the physicians' behaviour. | To analyze research results relating the feelings of adolescents connected with their medical visit and their perception of the physician's behaviour in treating them as patients during the visit. The research was conducted on a group of 14-15-year-olds (N=716), students of lower secondary schools located in 5 voivodes... | 25,182,397 | [
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[Large dentigerous cyst caused by retained tooth 25]. | Follicular cysts are benign, non-inflammatory odontogenic cysts, usually painless and discovered during routine radiographic examination. The article describes a case of a large follicular cyst with retained tooth 25. Pantomographic x ray showed the presence of a large follicular cyst located on the side of the impacte... | 25,182,400 | [
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[Multichannel electrogastrography in pediatrics - progress in standardisation and clinical application]. | Electrogastrography (EGG) is a non-invasive method to record gastric myoelectrical activity by means of electrodes placed on the abdominal surface. This technique allows to obtain information about gastric myoelectrical activity and indirectly about gastric motility, without affecting its physiological functions. Excep... | 25,182,402 | [
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Development of low postural tone compensatory patterns in children - theoretical basis. | Neurological literature indicates the existence of children with low postural tone without association with central nervous system damage. This fact induces to think about mechanisms, which allow these children to maintain upright posture. There is a suspicion that compensatory mechanism included in this process, enabl... | 25,182,403 | [
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Active invasion of bacteria into living fungal cells. | The rice seedling blight fungus Rhizopus microsporus and its endosymbiont Burkholderia rhizoxinica form an unusual, highly specific alliance to produce the highly potent antimitotic phytotoxin rhizoxin. Yet, it has remained a riddle how bacteria invade the fungal cells. Genome mining for potential symbiosis factors and... | 25,182,414 | [
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Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms. | In addition to its well-characterized role in the regulation of drug metabolism and transport by xenobiotics, pregnane X receptor (PXR) critically impacts on lipid homeostasis. In mice, both ligand-dependent activation and knockout of PXR were previously shown to promote hepatic steatosis. To elucidate the respective p... | 25,182,422 | [
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Surgical decision making in a teaching hospital: a linguistic analysis. | The aim of the study was to gain insight in the involvement of non-operating surgeons in intraoperative surgical decision making at a teaching hospital. The decision to proceed to clip and cut the cystic duct during laparoscopic cholecystectomy was investigated through direct observation of team work. Eleven laparoscop... | 25,182,451 | [
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Bicarbonate increases binding affinity of Vibrio cholerae ToxT to virulence gene promoters. | The major Vibrio cholerae virulence gene transcription activator, ToxT, is responsible for the production of the diarrhea-inducing cholera toxin (CT) and the major colonization factor, toxin coregulated pilus (TCP). In addition to the two primary virulence factors mentioned, ToxT is responsible for the activation of ac... | 25,182,489 | [
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Formation, structural characterization, and reactions of a unique cyclotrimeric vicinal Lewis pair containing (C6F5)2P-Lewis base and (C6F5)BH-Lewis acid components. | The synthesis of the new vicinal frustrated Lewis pair 5 containing (C6F5)2P-Lewis base and (C6F5)BH-Lewis acid functionality is described. It forms a unique cyclotrimer (5)3 which was structurally characterized by X-ray crystallography and high-resolution solid-state NMR spectroscopy. The relevant NMR Hamiltonian para... | 25,182,524 | [
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Stroke prophylaxis in atrial fibrillation: searching for management improvement opportunities in the emergency department: the HERMES-AF study. | We determine the prevalence of stroke prophylaxis prescription in emergency department (ED) patients with atrial fibrillation and the factors associated with a lack of prescription of anticoagulation in high-risk patients without contraindications. This was a multicenter, observational, cross-sectional study with prosp... | 25,182,543 | [
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Effects of melatonin on changes in cognitive performances and brain malondialdehyde concentration induced by sub-chronic co-administration of chlorpyrifos and cypermethrin in male Wister rats. | To evaluate the ameliorative effect of melatonin on sub-chronic chlorpyrifos (CPF) and cypermethrin (CYP)-evoked cognitive changes in male Wistar rats. Fifty adult male Wistar rats, divided into five groups of ten rats each, were used for the study. Groups 1 and II were given distilled water and soya oil (2 mL/kg) resp... | 25,182,558 | [
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Design, synthesis and evaluation of novel HDAC inhibitors as potential antitumor agents. | Phenyl imidazolidin-2-one was introduced as the linker for novel HDAC inhibitors. A focused library of 20 compounds was designed and synthesized, among which eight compounds showed equivalent or higher potencies against HDAC1 as compared to vorinostat. In vitro antitumor activity assays in HCT-116, PC-3 and HL-60 cance... | 25,182,565 | [
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A likelihood-based biostatistical model for analyzing consumer movement in simultaneous choice experiments. | Consumer feeding preference among resource choices has critical implications for basic ecological and evolutionary processes, and can be highly relevant to applied problems such as ecological risk assessment and invasion biology. Within consumer choice experiments, also known as feeding preference or cafeteria experime... | 25,182,616 | [
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Assessing probability of malignancy in solid solitary pulmonary nodules with a new Bayesian calculator: improving diagnostic accuracy by means of expanded and updated features. | A crucial point in the work-up of a solitary pulmonary nodule (SPN) is to accurately characterise the lesion on the basis of imaging and clinical data available. We introduce a new Bayesian calculator as a tool to assess and grade SPN risk of malignancy. A set of 343 consecutive biopsy or interval proven SPNs was used ... | 25,182,626 | [
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A population pharmacokinetic modeling approach shows that serum penicillin G concentrations are below inhibitory concentrations by two weeks after benzathine penicillin G injection in the majority of young adults. | Serum penicillin G falls to low levels 2 weeks after injection as benzathine penicillin G (BPG) in young adults. Using Pmetrics and previously reported penicillin G pharmacokinetic data after 1.2 million units were given as BPG to 329 male military recruits, here we develop the first reported population pharmacokinetic... | 25,182,635 | [
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Ramoplanin at bactericidal concentrations induces bacterial membrane depolarization in Staphylococcus aureus. | Ramoplanin is an actinomycetes-derived antibiotic with broad-spectrum activity against Gram-positive bacteria that has been evaluated in clinical trials for the treatment of gastrointestinal vancomycin-resistant enterococci (VRE) and Clostridium difficile infections. Recent studies have proposed that ramoplanin binds t... | 25,182,650 | [
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Prognostic impact of splenomegaly on survival of Chinese with primary myelofibrosis. | Predicting survival in persons with primary myelofibrosis (PMF) is typically based on the International Prognostic Scoring System (IPSS), the Dynamic IPSS (DIPSS) or the DIPSS-Plus. These scoring systems use clinical and laboratory data developed predominately in persons of European descent. Splenomegaly is not a progn... | 25,182,689 | [
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Antibacterial properties of lucifensin in Lucilia sericata maggots after septic injury. | To investigate the antibacterial properties of lucifensin in maggots of Lucilia sericata after septic injury. In our preliminary study we have shown that injuring the maggots with a needle soaked in lipopolysaccharide solution induced within 24 h lucifensin expression in the fat body and in the grease coupler of the sa... | 25,182,719 | [
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Tamarind seed coat extract restores reactive oxygen species through attenuation of glutathione level and antioxidant enzyme expression in human skin fibroblasts in response to oxidative stress. | To investigate the role and mechanism of tamarind seed coat extract (TSCE) on normal human skin fibroblast CCD-1064Sk cells under normal and oxidative stress conditions induced by hydrogen peroxide (H2O2). Tamarind seed coats were extracted with boiling water and then partitioned with ethyl acetate before the cell anal... | 25,182,723 | [
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Antisickling activity of butyl stearate isolated from Ocimum basilicum (Lamiaceae). | To perform phytochemical analyses on the leaves of Ocimum basilicum L. (O. basilicum), to elucidate the structure of isolate and then perform the antisickling activity on the crude extract and on the isolate. The Emmel test performed on the acidified methanolic extract of this plant was used to evaluate the antisicklin... | 25,182,725 | [
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In vivo NIRF imaging-guided delivery of a novel NGR-VEGI fusion protein for targeting tumor vasculature. | Pathological angiogenesis is crucial in tumor growth, invasion and metastasis. Previous studies demonstrated that the vascular endothelial growth inhibitor (VEGI), a member of the tumor necrosis factor superfamily, can be used as a potent endogenous inhibitor of tumor angiogenesis. Molecular probes containing the aspar... | 25,182,731 | [
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Pulse wave velocity as a marker of cognitive impairment in the elderly. | Carotid-femoral pulse wave velocity (PWV), an index of large artery stiffness, is a good proxy of arterial aging and also an independent marker of cardiovascular disease. A consistently growing number of studies has shown a significant inverse association of arterial aging and cognitive function: the greater the PWV, t... | 25,182,740 | [
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I716F AβPP mutation associates with the deposition of oligomeric pyroglutamate amyloid-β and α-synucleinopathy with Lewy bodies. | Autosomal dominant familial Alzheimer's disease (AD) is associated with mutations in the AβPP, PSEN1, and PSEN2 genes. The clinical phenotype associated with AβPP mutations is mainly characterized by dementia or by strokes related to cerebral amyloid angiopathy (CAA). We present a comprehensive clinical, neuropathologi... | 25,182,745 | [
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Mouse monoclonal antibodies against estrogen receptor. | The production of monoclonal antibodies, by cloning hybridoma derived from the fusion of myeloma cells and spleen lymphocytes, has allowed to obtain great advances in many fields of biological knowledge. The use of specific antibodies to the estrogen receptor, in fact, has been an invaluable method to bring out its mec... | 25,182,770 | [
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[Serum levels and clinical significance of high mobility group protein B1 in patients with delayed encephalopathy after acute carbon monoxide poisoning]. | To investigate the changes in serum level of high mobility group protein B1 (HMGB1) in patients with delayed encephalopathy after acute carbon monoxide poisoning and the clinical significance of these changes. Thirty-four patients with delayed encephalopathy after acute carbon monoxide poisoning (delayed encephalopathy... | 25,182,828 | [
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Fibrinogen and factor XIII at the intersection of coagulation, fibrinolysis and inflammation. | Fibrinogen and factor XIII are two essential proteins that are involved directly in fibrin gel formation as the final step of a sequence of reactions triggered by a procoagulant stimulus. Haemostasis is the most obvious function of the resulting fibrin clot. Different variables affect the conversion of fibrinogen to fi... | 25,182,841 | [
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Pericentral retinopathy and racial differences in hydroxychloroquine toxicity. | To describe patterns of hydroxychloroquine retinopathy distinct from the classic parafoveal (bull's eye) maculopathy. Retrospective case series. Patients from a large multi-provider group practice and a smaller university referral practice diagnosed with hydroxychloroquine retinopathy. Patients with widespread or "end-... | 25,182,842 | [
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A point of care test for the determination of amniotic fluid interleukin-6 and the chemokine CXCL-10/IP-10. | Intra-amniotic inflammation is a mechanism of disease implicated in preterm labor, preterm prelabor rupture of membrane, cervical insufficiency, a short cervix, and idiopathic vaginal bleeding. Determination of interleukin (IL)-6 with immunoassays has been proven for more than two decades to be an excellent method for ... | 25,182,862 | [
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The efficacy of risk scores for predicting abdominal wound dehiscence: a case-controlled validation study. | The medical literature includes two risk scores predicting the occurrence of abdominal wound dehiscence. These risk indices were validated by the authors on the populations studied. However, whether these scoring systems can accurately predict, abdominal wound dehiscence in other populations remains unclear. A retrospe... | 25,182,865 | [
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Mobile van drives up to screen TB. | Specialist tuberculosis (TB) nurses have been providing chest X-rays, blood testing and education for homeless people from a mobile van. | 25,182,884 | [
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Waterlogged app. | Set up a daily goal of how much water you would like to drink to stay hydrated and this excellent app will keep track of your intake and do all the arithmetic for you. | 25,182,911 | [
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The problem of obesity in the NHS all comes down to cost. | Well done to NHS England chief executive Simon Stevens for speaking up about the sensitive issue of obese nurses and the need for NHS staff to be healthy advocates (Analysis August 13, Editorial and Letters August 20 and Wright Angle August 27). | 25,182,916 | [
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Rugged and breathable forms of stretchable electronics with adherent composite substrates for transcutaneous monitoring. | Research in stretchable electronics involves fundamental scientific topics relevant to applications with importance in human healthcare. Despite significant progress in active components, routes to mechanically robust construction are lacking. Here, we introduce materials and composite designs for thin, breathable, sof... | 25,182,939 | [
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Target contact and exploration strategies in haptic search. | In a haptic search task, one has to detect the presence of a target among distractors using the sense of touch. A salient target can be detected faster than a non-salient target. However, little is known about the exploration strategies that are used, especially in 3D search tasks where items are held in the hand. In t... | 25,182,940 | [
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A retrospective evaluation of the quality of malaria case management at twelve health facilities in four districts in Zambia. | To establish the appropriateness of malaria case management at health facility level in four districts in Zambia. This study was a retrospective evaluation of the quality of malaria case management at health facilities in four districts conveniently sampled to represent both urban and rural settings in different epidem... | 25,182,953 | [
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KIT and BRAF heterogeneous mutations in gastrointestinal stromal tumors after secondary imatinib resistance. | Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumor of the digestive tract and characterized by expression of KIT protein. Imatinib is the frontline therapy for metastatic and unresectable GIST patients showing clinical responses in 80 % of cases. Despite the often long-lasting clinical benefi... | 25,182,956 | [
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Prevalence of the BLM nonsense mutation, p.Q548X, in ovarian cancer patients from Central and Eastern Europe. | A nonsense mutation, p.Q548X, in the BLM gene has recently been associated with an increased risk for breast cancer. In the present work, we investigated the prevalence of this Slavic founder mutation in 2,561 ovarian cancer cases from Russia, Belarus, Poland, Lithuania or Germany and compared its frequency with 6,205 ... | 25,182,961 | [
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GMO quantification: valuable experience and insights for the future. | Cultivation and marketing of genetically modified organisms (GMOs) have been unevenly adopted worldwide. To facilitate international trade and to provide information to consumers, labelling requirements have been set up in many countries. Quantitative real-time polymerase chain reaction (qPCR) is currently the method o... | 25,182,968 | [
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Biogenesis of lysosome-related organelles complex-1 subunit 1 (BLOS1) interacts with sorting nexin 2 and the endosomal sorting complex required for transport-I (ESCRT-I) component TSG101 to mediate the sorting of epidermal growth factor receptor into endosomal compartments. | Biogenesis of lysosome-related organelles complex-1 (BLOC-1) is a component of the molecular machinery required for the biogenesis of specialized organelles and lysosomal targeting of cargoes via the endosomal to lysosomal trafficking pathway. BLOS1, one subunit of BLOC-1, is implicated in lysosomal trafficking of memb... | 25,183,008 | [
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MicroRNA-539 is up-regulated in failing heart, and suppresses O-GlcNAcase expression. | Derangements in metabolism and related signaling pathways characterize the failing heart. One such signal, O-linked β-N-acetylglucosamine (O-GlcNAc), is an essential post-translational modification regulated by two enzymes, O-GlcNAc transferase and O-GlcNAcase (OGA), which modulate the function of many nuclear and cyto... | 25,183,011 | [
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Complications from catheter ablation of atrial fibrillation: impact of current and emerging ablation technologies. | Catheter ablation has emerged as an important therapy for atrial fibrillation. The past decade has seen tremendous growth in the use of this technology, as well as the use of novel sources and methods of energy delivery. As the volume and complexity of catheter ablation procedures for atrial fibrillation have increased... | 25,183,020 | [
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-0.189948... |
Individual and joint toxic effects of cadmium sulfate and α-naphthoflavone on the development of zebrafish embryo. | This paper aims to evaluate the individual and joint toxicities of cadmium sulfate (CdSO4) and α-naphthoflavone (ANF) in zebrafish embryos. As a result, CdSO4 caused both lethal and sub-lethal effects, such as 24 h post-fertilization (hpf) death and 72 hpf delayed hatching. However, ANF only caused sub-lethal effects, ... | 25,183,031 | [
-0.2882691,
0.1945797,
0.02016359,
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0.2379667,
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0.2797989,
0.1657836,
0.1765795,
0.3757717,
0.1144147,
0.119913,
0.09503543,
0.09433689,
0.005308337,
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0.2164582,
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0.6206004,
0.1486992,
0.0477142,
-0.3133595,
0.040... |
A novel variant in TBX20 (p.D176N) identified by whole-exome sequencing in combination with a congenital heart disease related gene filter is associated with familial atrial septal defect. | Congenital heart disease (CHD) is the leading cause of birth defects, and its etiology is not completely understood. Atrial septal defect (ASD) is one of the most common defects of CHD. Previous studies have demonstrated that mutations in the transcription factor T-box 20 (TBX20) contribute to congenital ASD. Whole-exo... | 25,183,037 | [
0.02604409,
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-0.1933608,
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0.2263983,
0.02256785,
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0.05897535,
0.167707,
0.08449488,
0.07573453,
0.5780878,
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0.07400715,
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-0.5456098,
-0.2026995,
0.2677636,
-0.124633,
-0.09739139,
0.3679549,
-0.2109828,... |
TGF-beta induced RBL2 expression in renal cancer cells by down-regulating miR-93. | TGF-beta can induce G1 arrest via many mechanisms including up-regulating p21, p27, and Rb. However, as the member of Rb family, whether RBL2 is induced by TGF-beta treatment remains exclusive. The expression of RBL2 and miR-93 after TGF-beta treatment was determined by quantitative real-time PCR and western blot. The ... | 25,183,046 | [
-0.07319768,
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-0.09508184,
-0.1526831,
0.4918924,
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0.1840736,
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0.3161704,
0.2363171,
0.5847927,
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0.05731887,
-0.04920121,
0.3070259,
0.302251,
0.2295882,
-0.06191171... |
Pattern, challenges and correlates of condom use among Nigerians living with HIV infection. | To determine the pattern, challenges and correlates of condom use among Nigerians living with HIV Infection. A cross sectional questionnaire study among HIV positive adults attending an HIV treatment centre in Lagos, Nigeria. Data entry and analysis were done with Epi-info version 3.5.1. The mean age of respondents was... | 25,183,080 | [
-0.1720935,
0.2271376,
0.01382637,
0.1387354,
0.2609743,
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0.17048,
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0.2222224,
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0.3370018,
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-0.4373339,
-0.1095702,
-0.2403124,
0.1878209,
0.1488896,
0.1487755,
-0.2829329,
0.... |
Ethno botanical and Phytophrmacological potential of Abrus precatorius L.: A review. | Medicinal plants are being widely used, either as a single drug or in combination in health care delivery system. Medicinal plants can be important source of previously unknown chemical substances with potential therapeutic effects. Abrus precatorius L. is commonly known as Gunja or Jequirity and abundantly found all t... | 25,183,095 | [
0.1105889,
0.07373177,
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0.2748156,
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0.05925969,
0.168583,
0.0669578,
0.1796432,
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0.4734665,
0.1752075,
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0.2007737,
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0.3825514,
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-0.2227192,
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... |
Studies on the antibacterial activity of Khaya senegalensis [(Desr.) A. Juss)] stem bark extract on Salmonella enterica subsp. enterica serovar Typhi [(ex Kauffmann and Edwards) Le Minor and Popoff]. | To study the phytochemical screening and antibacterial activity of the stem bark extracts of Khaya senegalensis (K. senegalensis) against Salmonella enterica subsp. enterica serovar Typhi. The plant components were extracted using methanol, ethanol and water. The phytochemical screening of the stem bark extracts were c... | 25,183,098 | [
-0.004221049,
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0.151134,
0.02121588,
0.3125314,
-0.0008776013,
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0.1854252,
0.1850717,
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0.1448776,
0.08541765,
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0.08942696,
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-0.4292865,
0.07897606,
-0.2277041,
0.3557836,
0.4147381,
-0.02075864,
-0.14... |
Microbiological quality of indoor air in university libraries. | To evaluate the concentration of bacteria and fungi in the indoor environment of Jimma University libraries, so as to estimate the health hazard and to create standards for indoor air quality control. The microbial quality of indoor air of eight libraries of Jimma University was determined. The settle plate method usin... | 25,183,103 | [
-0.1216071,
-0.1971136,
0.472586,
0.07953839,
-0.1366848,
0.09505501,
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0.2114548,
0.2064234,
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0.008199027,
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0.005834053,
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0.376083,
-0.1108149,
0.1549162,
0.4287125,
-0.04739171,
0.09861312,
0.4655451,
0.00861837,
... |
Production, purification and characterization of bacteriocin from Lactobacillus murinus AU06 and its broad antibacterial spectrum. | To study the production, purification and characterization of bacteriocin from Lactobacillus murinus AU06 isolated from marine sediments and its broad spectrum of inhibition against fish pathogens. The selected strain was used in production, purification and characterized of bacteriocin. In addition, purified bacterioc... | 25,183,102 | [
0.075971,
-0.2698262,
0.1836301,
0.04550222,
0.10207,
0.04321891,
-0.1647793,
0.4290386,
0.4250042,
-0.3644659,
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-0.07423162,
0.02380058,
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0.169295,
0.2583374,
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0.1830137,
0.1981528,
-0.1551398,
0.02468312,
-0.1429655,
-0.213152,
-0.1336... |
Antioxidant and anti-acetylcholinesterase activities of extracts and secondary metabolites from Acacia cyanophylla. | To investigate the antioxidant potential and anti-acetycholinesterase activity of compounds and extracts from Acacia cyanophylla (A. cyanophylla). Three polyphenolic compounds were isolated from ethyl acetate extract of A. cyanophylla flowers. They have been identified as isosalipurposide 1, quercetin 2 and naringenin ... | 25,183,120 | [
-0.08576766,
0.4119558,
0.005140535,
0.07317813,
0.1045272,
0.1318228,
-0.6019379,
0.1465935,
0.1626881,
-0.2504493,
0.09865572,
0.1098772,
0.05681585,
-0.1809634,
-0.5309634,
0.1713855,
-0.7170909,
0.4749214,
0.09889473,
0.3518698,
-0.0456647,
0.02701238,
-0.07116759,
... |
Evaluation of plasma H2S levels and H2S synthesis in streptozotocin induced Type-2 diabetes-an experimental study based on Swietenia macrophylla seeds. | To evaluate the plasma H2S levels and H2S synthesis activity in streptozotocin induced type 2 diabetes rats compared to the healthy controls and also to observe the effect of the aqueous extract of Swietenia macrophylla (S. macrophylla) seeds on the experimental groups. Seeds of S. macrophylla were separated, washed, s... | 25,183,134 | [
0.04823899,
-0.08252535,
-0.272396,
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0.204163,
-0.5008132,
-0.2178028,
-0.0342844,
0.1051806,
-0.4153357,
0.162484,
0.5589213,
-0.084583,
-0.22325,
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0.2620391,
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0.1496105,
0.1168992,
0.08284717,
-0.06241238,
-0.06823551,
-... |
Antibacterial activity of the essential oils of myrtle leaves against Erysipelothrix rhusiopathiae. | To evaluate the antibacterial activity of the essential oil of Myrtus communis (M. communis) L. against Erysipelothrix rhusiopathiae (E. rhusiopathiae) in vitro. Wild populations of M. communis collected from Khuzestan and Lorestan provinces, Southwest Iran, were examined for antibacterial activity and chemical variabi... | 25,183,140 | [
0.06744839,
0.1864484,
0.2228508,
0.08655361,
0.1451669,
0.06371282,
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0.04713529,
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0.3035024,
0.2758896,
0.00723668,
0.1429338,
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-0.2698801,
0.4498813,
-0.04807784,
0.1010406,
0.4745194,
-0.04406096,
0.3200823,
-... |
Urinary excretion of N-nitroso compounds in rats fed sodium nitrite and/or hot dogs. | Nitrite-treated meat is a reported risk factor for colon cancer. Mice that ingested sodium nitrite (NaNO2) or hot dogs (a nitrite-treated product) showed increased fecal excretion of apparent N-nitroso compounds (ANC). Here, we investigated for the first time whether rats excrete increased amounts of ANC in their urine... | 25,183,213 | [
-0.202982,
0.355476,
-0.5874338,
-0.1409634,
0.02650149,
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0.1952242,
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0.09680485,
0.006578689,
0.2493941,
-0.4337238,
-0.5362043,
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0.1236346,
0.009932518,
-0.05106078,
-0.01750995,
0.2748005,
-0.1209647... |
Cosmetic lower limb lengthening by Ilizarov apparatus: what are the risks? | Compelled by the psychosocial implications of short stature, patients with short stature are increasingly undergoing distraction osteogenesis for cosmetic limb lengthening. To the degree that this is true, evaluation of the risks and benefits of this treatment are very important, but to date, there are few studies repo... | 25,183,215 | [
-0.004717469,
0.1032061,
0.00654106,
-0.01268525,
0.1120986,
-0.3291708,
-0.232713,
0.1070115,
-0.02452376,
-0.2367713,
0.01625802,
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-0.2228556,
-0.1158362,
-0.1217566,
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-0.1803793,
-0.1217405,
-0.1111852,
0.1967708,
-0.05610262,
0.2334498,
-0.358034... |
Impact of treatment on survival in polymyositis and dermatomyositis. A single-centre long-term follow-up study. | To assess the long-term outcome in polymyositis (PM) and dermatomyositis (DM), with a particular emphasis on mortality and influence of treatment. Diagnosis was based according to the Bohan and Peter's criteria. Patients have been followed up by a standardised protocol. Deaths were registered and causes of death were a... | 25,183,232 | [
0.0168587,
-0.4097676,
-0.0573179,
-0.4550376,
0.07976918,
-0.07308611,
-0.004638365,
0.4962031,
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-0.3161806,
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0.1151615,
0.2707438,
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0.1700087,
0.04061955,
0.1158003,
0.2840082,
0.3580215,
0.2451651,
-0.07642268,
... |
Adaptable synthesis of C-lactosyl glycoclusters and their binding properties with galectin-3. | We report here the syntheses of mono- to tetravalent glycoclusters containing 1-methylene-C-β-lactose. The 1-methylene-C-β-lactose moiety has been synthesized from octa-acetyl-β-lactose using the key carbonyl insertion reaction and linked to a series of alkynlated scaffolds via CuAAC reaction to afford mono- to tetrava... | 25,183,239 | [
-0.0767605,
-0.221558,
0.04261583,
0.2693542,
0.01143535,
0.07139482,
-0.5268589,
0.211253,
0.260592,
0.2695325,
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0.03757674,
0.1191172,
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0.2663352,
-0.6275727,
0.2355709,
0.04155244,
-0.1323272,
0.3637308,
0.1060772,
-0.259253,
0.02646... |
Microfluidic platform for the quantitative analysis of leukocyte migration signatures. | Leukocyte migration into tissues is characteristic of inflammation. It is usually measured in vitro as the average displacement of populations of cells towards a chemokine gradient, not acknowledging other patterns of cell migration. Here, we designed and validated a microfluidic migration platform to simultaneously an... | 25,183,261 | [
0.1164782,
0.08777753,
-0.1854054,
-0.05124193,
0.1714852,
-0.1823411,
-0.2085862,
0.242826,
0.1227009,
-0.162315,
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0.06310219,
-0.05679346,
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0.005529198,
-0.1831949,
-0.152674,
-0.3179703,
0.3456073,
0.03668202,
0.2167626,
0.08256111,
... |
Cytotoxicity screening of Melastoma malabathricum extracts on human breast cancer cell lines in vitro. | To screen the cytotoxic activity of Melastoma malabathricum (M. malabathricum) against human breast cancer cell line (MCF-7) in vitro. A three steps extraction protocol using n-hexane, chloroform and methanol as the solvents systems was carried out on leaves, stems and flowers of M. malabathricum. Dimethyl sulfoxide wa... | 25,183,274 | [
-0.3521312,
0.006335017,
0.08331854,
-0.4681419,
-0.03613762,
0.1579175,
-0.1928297,
0.2161926,
0.04885623,
-0.2696529,
0.1902879,
0.2300973,
-0.03655402,
0.1164847,
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0.2376131,
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0.4008751,
-0.1421217,
0.2439988,
0.521942,
0.0872449,
0.1165567,
0.... |
Modified technique of Wolbachia removal from Malaysian Aedes albopictus. | To develop an artificial and modified Wolbachia removal technique using tetracycline from naturally Wolbachia infected Aedes albopictus (Ae. albopictus) so as to be able to produce generations of Wolbachia free offsprings. In this study, seven different tetracycline treatment methods were conducted to obtain the best r... | 25,183,276 | [
0.1954324,
0.2113017,
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0.08677749,
0.02231304,
-0.354533,
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0.02500648,
0.1860788,
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0.3201501,
0.0103838,
0.09127371,
0.1033545,
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-0.5272284,
-0.0092754,
-0.2658229,
-0.301493,
-0.1943362,
-0.01339387,
-0.2691853,
... |
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