title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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A wire transposition technique for recanalization of chronic complex central venous occlusions. | A minimal-invasive interventional technique for recanalization of complex chronic central venous total occlusions is described to overcome difficulties in case of failure of common approaches. We present a patient with a central venous occlusion that caused severe venous congestion of her upper extremity and significan... | 25,178,813 | [
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Stimulation of oxidative phosphorylation by calcium in cardiac mitochondria is not influenced by cAMP and PKA activity. | Cardiac oxidative ATP generation is finely tuned to match several-fold increases in energy demand. Calcium has been proposed to play a role in the activation of ATP production via PKA phosphorylation in response to intramitochondrial cAMP generation. We evaluated the effect of cAMP, its membrane permeable analogs (dibu... | 25,178,840 | [
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Disability in post-earthquake Haiti: prevalence and inequality in access to services. | To assess the prevalence of disability and service needs in post-earthquake Haiti, and to compare the inclusion and living conditions of people with disabilities to those without disabilities. A population-based prevalence survey of disability was undertaken in 2012 in Port-au-Prince region, which was at the centre of ... | 25,178,862 | [
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Why wait? The effect of wait-times on subsequent help-seeking among families looking for children's mental health services. | Placement on a wait-list may increase families' help-seeking efforts, leading them to contact more than one children's mental health (MH) agency/professional. Two issues were examined in the current study: 1) Does time on a wait-list for families impact the time to contact a new agency for children's MH services? 2) Wh... | 25,178,864 | [
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Carnosic acid induces autophagic cell death through inhibition of the Akt/mTOR pathway in human hepatoma cells. | The therapeutic goal of cancer treatment is now geared towards triggering tumour-selective cell death with autophagic cell death being required for the chemotherapy of apoptosis-resistant cancer. In this study, Carnosic acid (CA), a polyphenolic diterpene isolated from Rosemary (Rosemarinus officinalis), significantly ... | 25,178,877 | [
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Chronic cough: a herald symptom of thoracic aortic aneurysm in a patient with a bicuspid aortic valve. | Chronic cough has a wide differential, of which thoracic aortic aneurysm is a rare but potentially devastating cause. We present a patient with previous aortic valve replacement for a bicuspid valve who had been suffering from a chronic cough for 8 months and who developed subsequent voice hoarseness. This had been ini... | 25,178,892 | [
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A mixed methods study of food safety knowledge, practices and beliefs in Hispanic families with young children. | Children are at a higher risk for foodborne illness. The objective of this study was to explore food safety knowledge, beliefs and practices among Hispanic families with young children (≤10 years of age) living within a Midwestern state. A convergent mixed methods design collected qualitative and quantitative data in p... | 25,178,898 | [
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Do portrayals of women in action convey another ideal that women with little self-determination feel obligated to live up to? Viewing effects on body image evaluations and eating behaviors. | Theoretical and empirical research suggests that valuing the body in terms of its functionality and physical competence (rather than its appearance) may improve women's relationships with their body and food. We tested this proposition by investigating women's responses to contrasting portrayals of the female body as a... | 25,178,899 | [
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Delivery-related knowledge of mothers of NICU infants compared with well-baby-nursery infants. | The objective of this study was to compare the knowledge of mothers of newborns in a neonatal intensive care unit (NICU) and well-baby nursery (WBN) regarding their understanding of term gestation, delivery mode safety, and elective late preterm delivery. Mothers of newborns admitted to either an NICU (n=88) or a WBN (... | 25,178,903 | [
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Prokaryotic membrane vesicles: new insights on biogenesis and biological roles. | Biogenesis and trafficking of membrane vesicles are essential and well-studied processes in eukaryotes. In contrast, vesiculation in bacteria is not well understood. Outer membrane vesicles (OMVs) are produced in Gram-negative bacteria by blebbing of the outer membrane. In addition to the roles in pathogenesis, cell-to... | 25,178,905 | [
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An inverse association between West Nile virus serostatus and avian malaria infection status. | Various ecological and physiological mechanisms might influence the probability that two or more pathogens may simultaneously or sequentially infect a host individual. Concurrent infections can have important consequences for host condition and fitness, including elevated mortality risks. In addition, interactions betw... | 25,178,911 | [
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Being a neighbor to Syria: a retrospective analysis of patients brought to our clinic for cranial gunshot wounds in the Syrian civil war. | Toward the end of 2010, the Arab spring, the waves of revolutionary demonstrations and protests influenced also Syria, where violent clashes turned into a civil war. Hundreds of thousands of people became refugees. The use of excessive force unfortunately culminated in numerous deaths and injuries in many cities. Being... | 25,178,917 | [
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Bioinspired orientation-dependent friction. | Spatular terminals on the toe pads of a gecko play an important role in directional adhesion and friction required for reversible attachment. Inspired by the toe pad design of a gecko, we study friction of polydimethylsiloxane (PDMS) micropillars terminated with asymmetric (spatular-shaped) overhangs. Friction forces i... | 25,178,923 | [
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Unilateral NMR investigation of multifunctional treatments on stones based on colloidal inorganic and organic nanoparticles. | Consolidation and protection are among the most important treatments usually carried out in conservation of stone artifacts and monuments. In this paper, portable unilateral NMR and conventional techniques were used for investigating new multifunctional treatments based on tetraethoxysilane, silica, and polytetrafluoro... | 25,178,927 | [
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Who am I? The relationship between self-concept uncertainty and materialism. | It is well accepted that materialism may result in a number of negative consequences, hence the importance of improving its understanding. In this paper, we propose that materialism negatively relates to self-concept uncertainty. Uncertainty about oneself is aversive and those feeling uncertain may use the possession o... | 25,178,953 | [
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Hydroxy-tryptophan containing derivatives of tritrpticin: modification of antimicrobial activity and membrane interactions. | Tritrpticin is an antimicrobial peptide with a strong microbicidal activity against Gram-positive and Gram-negative bacteria as well as fungi. The 13-residue peptide is essentially symmetrical and possesses a unique cluster of three Trp residues near the center of its amino acid sequence. The mechanism of action of tri... | 25,178,967 | [
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Clinical handovers between prehospital and hospital staff: literature review. | Clinical handover plays a vital role in patient care and has been investigated in hospital settings, but less attention has been paid to the interface between prehospital and hospital settings. This paper reviews the published research on these handovers. A computerised literature search was conducted for papers publis... | 25,178,977 | [
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No longer an untreatable disease: how targeted and immunotherapies have changed the management of melanoma patients. | The discovery that BRAF is a driver oncogene in cancer, and complementary improvements in our understanding of the immune system have resulted in new targeted and immune-therapies for metastatic melanoma. Targeted therapies achieve impressive clinical results in carefully selected patients but the development of resist... | 25,178,978 | [
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Differences determined by optical coherence tomography volumetric analysis in non-culprit lesion morphology and inflammation in ST-segment elevation myocardial infarction and stable angina pectoris patients. | While the current methodology for determining fibrous cap (FC) thickness of lipid plaques is based on manual measurements of arbitrary points, which could lead to high variability and decreased accuracy, it ignores the three-dimensional (3-D) morphology of coronary artery disease. To compare, utilizing optical coherenc... | 25,178,981 | [
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Sustained, new, never, and discontinued tobacco cessation services adopters. | This study examined longitudinal adoption patterns of tobacco cessation (TC) counseling and TC pharmacotherapy in substance use disorder treatment programs and baseline predictors (program characteristics and program culture) of these patterns 12-months later. Telephone survey data were collected in 2010 from 685 rando... | 25,178,991 | [
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Induction of apoptosis in cervical cancer cells by the duplex drug 5-FdU-ECyd, coupling 2'-deoxy-5-fluorouridine and 3'-C-ethinylcytidine. | Therapeutic options are limited for patients with advanced cervical cancer, and more effective drugs with favorable side-effect profiles are needed. We developed a nucleoside analogue duplex drug (5-FdU-ECyd), in which the DNA synthesis inhibitor 5-fluorodeoxyuridine is coupled to the RNA synthesis inhibitor 3'-C-ethin... | 25,178,996 | [
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Unsuspected allergic contact dermatitis to alcohol swabs following neurosurgery. | We report a case of a 12-year-old girl with severe allergic contact dermatitis following neurosurgery secondary to topical use of isopropyl alcohol swabs. Alcohol swabs should not be overlooked as potential allergens. In our case, it was initially assumed that the cause of her reaction was either tapes or topical local... | 25,179,004 | [
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On the coordination chemistry of phosphinecarboxamide: assessing ligand basicity. | We describe the coordination chemistry of the primary phosphine PH2C(O)NH2 (phosphinecarboxamide) towards group 6 transition-metals. Experimental and theoretical studies reveal that this novel species has comparable electronic properties to PH3. | 25,179,007 | [
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Use of a nutrition support protocol to increase enteral nutrition delivery in critically ill patients. | Early enteral nutrition is recommended for patients in intensive care units, but nutrition provision is often hindered by a variety of unit-specific problems. To evaluate the impact of a nutrition support protocol on nutrition prescription and delivery in the intensive care unit. Nutrition-related data from 73 patients... | 25,179,035 | [
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In vitro testing the potential of a novel chimeric IgG variant for inhibiting collagen fibrils formation in recurrent hereditary gingival fibromatosis: chimeric antibody in a gingival model. | Gingival fibromatosis is a progressive enlargement of the gingiva. It may hinder oral cavity hygiene and result in underlying bone loss. The long-term benefits of surgery cannot be predicted. On the other hand, alternative, efficient and non-invasive methods are not available at present. The aim of this study was to te... | 25,179,091 | [
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Fabrication of an anti-viral air filter with SiO₂-Ag nanoparticles and performance evaluation in a continuous airflow condition. | In this study, SiO2 nanoparticles surface coated with Ag nanoparticles (SA particles) were fabricated to coat a medium air filter. The pressure drop, filtration efficiency, and anti-viral ability of the filter were evaluated against aerosolized bacteriophage MS2 in a continuous air flow condition. A mathematical approa... | 25,179,108 | [
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Replication of Brucella abortus and Brucella melitensis in fibroblasts does not require Atg5-dependent macroautophagy. | Several intracellular bacterial pathogens have evolved subtle strategies to subvert vesicular trafficking pathways of their host cells to avoid killing and to replicate inside the cells. Brucellae are Gram-negative facultative intracellular bacteria that are responsible for brucellosis, a worldwide extended chronic zoo... | 25,179,110 | [
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High resolution 3D MRI of mouse mammary glands with intra-ductal injection of contrast media. | The purpose of this study was to use high resolution three-dimensional (3D) magnetic resonance imaging (MRI) to study mouse mammary gland ductal architecture based on intra-ductal injection of contrast agents. Female FVB/N mice age 12-20 weeks (n=12), were used in this study. A 34G, 45° tip Hamilton needle with a 25μL ... | 25,179,139 | [
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Life Origination Hydrate Theory (LOH-Theory) and the explanation of the biological diversification. | The Life Origination Hydrate Theory (LOH-Theory) considers the life origination process as a sequence of thermodynamically caused regular and inevitable chemical transformations regulated by universal physical and chemical laws. The LOH-Theory bears on a number of experimental, thermodynamic, observation, and simulatio... | 25,179,143 | [
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Metformin exaggerates phenylephrine-induced AMPK phosphorylation independent of CaMKKβ and attenuates contractile response in endothelium-denuded rat aorta. | Metformin, a widely prescribed antidiabetic drug, has been shown to reduce the risk of cardiovascular disease, including hypertension. Its beneficial effect toward improved vasodilation results from its ability to activate AMPK and enhance nitric oxide formation in the endothelium. To date, metformin regulation of AMPK... | 25,179,145 | [
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Wireless mobile technology to improve workflow and feasibility of MR-guided percutaneous interventions. | A wireless interactive display and control device combined with a platform-independent web-based user interface (UI) was developed to improve the workflow for interventional magnetic resonance imaging (iMRI). The iMRI-UI enables image acquisition of up to three independent slices using various pulse sequences with diff... | 25,179,151 | [
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Induction of complementary function reductase enzymes in colon cancer cells by dithiole-3-thione versus sodium selenite. | Cellular induction of reductase enzymes can alter the susceptibility of cells toward drugs and chemicals. In this study, we compared the capacity of a single dose of sodium selenite and 3H-1,2-dithiole-3-thione (D3T) to influence the drug-relevant reducing capacity of HT29 cells over time, and defined the protein-speci... | 25,179,160 | [
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The Nigeria Independent Accountability Mechanism for maternal, newborn, and child health. | Since the 2010 launch of the UN Secretary-General's Global Strategy for Women's and Children's Health, worldwide political energy coalesced around improving the health of women and children. Nigeria acted on a key recommendation emerging from the Global Strategy and became one of the first countries to establish an ind... | 25,179,169 | [
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Linking polymorphic p53 response elements with gene expression in airway epithelial cells of smokers and cancer risk. | Chronic cigarette smoking exposes airway epithelial cells to thousands of carcinogens, oxidants and DNA-damaging agents, creating a field of molecular injury in the airway and altering gene expression. Studies of cytologically normal bronchial epithelial cells from smokers have identified transcription-based biomarkers... | 25,179,167 | [
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MicroRNA-34 family expression in bovine gametes and preimplantation embryos. | Oocyte fertilization and successful embryo implantation are key events marking the onset of pregnancy. In sexually reproducing organisms, embryogenesis begins with the fusion of two haploid gametes, each of which has undergone progressive stages of maturation. In the final stages of oocyte maturation, minimal transcrip... | 25,179,211 | [
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Designing hybrid onconase nanocarriers for mesothelioma therapy: a Taguchi orthogonal array and multivariate component driven analysis. | Onconase (ONC) is a member of a ribonuclease superfamily that has cytostatic activity against malignant mesothelioma (MM). The objective of this investigation was to develop bovine serum albumin (BSA)-chitosan based hybrid nanoformulations for the efficient delivery of ONC to MM while minimizing the exposure to normal ... | 25,179,221 | [
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Score_set: a CAPRI benchmark for scoring protein complexes. | Critical Assessment of PRedicted Interactions (CAPRI) has proven to be a catalyst for the development of docking algorithms. An essential step in docking is the scoring of predicted binding modes in order to identify stable complexes. In 2005, CAPRI introduced the scoring experiment, where upon completion of a predicti... | 25,179,222 | [
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'Bubble-free' electrochemical delamination of CVD graphene films. | The production of large amounts of hydrogen bubbles, typical of electrochemical delamination methods based on the electrolysis of water, results in mechanical damage to graphene during the delamination, transfer, and drying steps. Here a novel 'bubble-free' delamination method is introduced which exploits the electroch... | 25,179,223 | [
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Curcumin derivative with the substitution at C-4 position, but not curcumin, is effective against amyloid pathology in APP/PS1 mice. | Recent evidence supports the amyloid cascade hypothesis that a pathological change of amyloid β (Aβ) in the brain is an initiating event in Alzheimer's disease (AD). Accordingly, modulating the abnormal Aβ aggregation is considered a potential therapeutic target in AD. Curcumin, a low-molecular-weight polyphenol derive... | 25,179,227 | [
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Role of 5-HT7 receptors in the inhibition of the vasodepressor sensory CGRPergic outflow in pithed rats. | The role of calcitonin gene-related peptide (CGRP) in the modulation of vascular tone has been widely documented. Indeed, electrical stimulation of the perivascular sensory outflow in pithed rats induces vasodepressor responses by activation of CGRP receptors. This study investigated the role of 5-HT7 receptors in the ... | 25,179,247 | [
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Metabolic imaging in non-small-cell lung cancer radiotherapy. | Metabolic imaging by positrons emission tomography (PET) offers new perspectives in the field of non-small-cell lung cancer radiation therapy. First, it can be used to refine the way nodal and primary tumour target volumes are selected and delineated, in better agreement with the underlying tumour reality. In addition,... | 25,179,249 | [
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[Intensity-modulated radiotherapy in head and neck cancer: ethics and methodology]. | Numerous studies have shown that intensity-modulated radiation therapy is the standard technique for the radiation treatment of head and neck cancers. Intensity-modulated radiation therapy reduces side effects (xerostomia, dysphagia, fibrosis, etc.) and improves the results for cancer localizations with highly complex ... | 25,179,256 | [
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Narrowing the localization of the region breakpoint in most frequent Robertsonian translocations. | Despite that Robertsonian translocations (ROBs) are the most common chromosomal rearrangements in humans (1/1000 individuals), an exact breakpoint and the molecular mechanisms leading to their formation are still not well known. This is partly due to the fact that Human Genome Project did not provide any map or sequenc... | 25,179,263 | [
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Gastrointestinal involvement in systemic sclerosis. | Systemic sclerosis is an autoimmune chronic disease characterised by microvascular, muscular and immunologic abnormalities that lead to progressive and systemic deposition of connective tissue in the skin and internal organs. The gastrointestinal tract is often overlooked by physicians but it is the most affected organ... | 25,179,275 | [
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Pathophysiology of systemic sclerosis: state of the art in 2014. | Major work has been done in order to improve the understanding of systemic sclerosis (SSc) pathogenesis. A number of new experimental models have been set up, that should help to understand the disease pathogenesis and test new therapeutic targets. Reactive oxygen species represent a hallmark of the pathogenesis of SSc... | 25,179,277 | [
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Evaluation of quadrupole-time-of-flight mass spectrometry in comprehensive two-dimensional gas chromatography. | Quadrupole time-of-flight mass spectrometry (Q-TOFMS) has been evaluated with respect to its applicability in comprehensive two-dimensional gas chromatography (GC×GC). At a maximum acquisition frequency, while approximately 50 full accurate mass spectra on disk were acquired per s (50Hz) in scan mode, the sampling rate... | 25,179,286 | [
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Clinical observations in alopecia areata: Implications and hypotheses. | Alopecia areata (AA) is a T-cell-mediated hair loss disorder but the exact cause is unknown. In this report we describe patterns of onset, regrowth and relapse in AA and propose potential underlying mechanisms. We believe that these aspects of AA require integration into modern theories of AA pathogenesis. | 25,179,296 | [
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Maximal acetylcholine dose of 200 μg into the left coronary artery as a spasm provocation test: comparison with 100 μg of acetylcholine. | As a spasm provocation test of acetylcholine (ACH), incremental dose up (20/50/100 μg) into the left coronary artery (LCA) is recommended in the guidelines established by Japanese Circulation Society. Recently, Ong et al. reported the ACOVA study which maximal ACH dose was 200 μg in the LCA. We compared the angiographi... | 25,179,297 | [
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Effect of a ventilator-focused intervention on the rate of Acinetobacter baumannii infection among ventilated patients. | Acinetobacter baumannii is a leading cause of ventilator-associated pneumonia, often as a result of ventilator equipment contamination. Evidence-based guidance on optimal care of ventilator equipment to prevent infection is lacking. Here, we report on a significant and persistent reduction in A baumannii infection rate... | 25,179,333 | [
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Evaluation of the short-term and long-term effect of a short series of hand hygiene campaigns on improving adherence in a tertiary care hospital in India. | Hand hygiene compliance at our institution was monitored by direct observation before and after a series of 2 hand hygiene awareness campaigns across an18-month time period to analyze the effect of these campaigns. A total of 5,059 opportunities for hand hygiene were observed. Compliance increased from 28.1% (95% confi... | 25,179,336 | [
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Evaluation of 2 sets of screening criteria for ventilator-associated pneumonia in a children's hospital. | We compared current Centers for Disease Control and Prevention surveillance criteria with the newer adult screening criteria (ASC) for identifying pediatric ventilator-associated pneumonia (VAP). Possible cases of VAP identified by ASC (n = 17) and cases of VAP identified by the older current surveillance criteria (n =... | 25,179,337 | [
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Challenge of managing distal femur fractures with long-stemmed total knee implants. | Treatment of distal femur fractures by long-stemmed total knee arthroplasty (TKA) is challenging, because of poor bone stock, decreased blood supply, history of multiple knee surgeries and an absence of standard treatment. Few published studies are available concerning this. The purpose of this study was to share surgi... | 25,179,356 | [
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Laser scanning photothermal microscopy: fast detection and imaging of gold nanoparticles. | We report on the design and construction of a laser scanning photothermal microscope and present images of gold nanoparticles of size as small as 5 nm. Laser scanning method allows fast image acquisition at 80 μs pixel dwell time so that a 500 × 500 pixel image is acquired in 20 s. Photothermal imaging at fast time sca... | 25,179,372 | [
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Preappointment testing for BRAF/KIT mutation in advanced melanoma: a model in molecular data delivery for individualized medicine. | The emergence of individualized medicine is driven by developments in precision diagnostics, epitomized by molecular testing. Because treatment decisions are being made based on such molecular data, data management is gaining major importance. Among data management challenges, creating workflow solutions for timely del... | 25,179,409 | [
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Self-efficacy and affect as mediators between pain dimensions and emotional symptoms and functional limitation in women with fibromyalgia. | The aim of this study was to investigate the role of self-efficacy and affect as mediators of the relationship between pain and several fibromyalgia (FM) symptoms (functional limitation, depression, and anxiety). We evaluated 144 women with FM for self-reported pain (numerical pain scale), pressure pain sensitivity (pr... | 25,179,423 | [
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Study of structural, electronic and optical properties of tungsten doped bismuth oxychloride by DFT calculations. | First-principle calculations have been carried out to investigate structural stabilities, electronic structures and optical properties of tungsten doped bismuth oxychloride (BiOCl). The structures of substitutional and interstitial tungsten, and in the form of WO6-ligand-doped BiOCl are examined. The substitutional and... | 25,179,434 | [
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Epidemiology of Clostridium difficile: a hospital-based descriptive study in Argentina and Mexico. | A prospective study was conducted in four tertiary hospitals in Argentina and Mexico in order to describe the occurrence of Clostridium difficile infection (CDI) in these settings. The objective was to evaluate the incidence of CDI in at-risk populations in Argentina (one center) and Mexico (three centers) and to furth... | 25,179,510 | [
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Overuse of compression ultrasound for patients with lower extremity cellulitis. | Compression ultrasound (CUS) is often ordered in hospitalized patients with cellulitis to assess for deep vein thrombosis (DVT). Despite this common practice, the rate of use and utility of CUS has not been well described. We conducted a retrospective cohort study of adult patients with lower extremity cellulitis hospi... | 25,179,516 | [
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Molecular basis of the clotting defect in a bleeding patient missing the Asp-185 codon in the factor X gene. | Factor X (FX) is a vitamin K-dependent plasma zymogen, which following activation to factor Xa (FXa), converts prothrombin to thrombin in the blood clotting cascade. It was recently demonstrated that a natural variant of FX carrying the Asp-185 deletion (FX-D185del, chymotrypsinogen numbering) was associated with mild ... | 25,179,519 | [
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Assessing accuracy in citizen science-based plant phenology monitoring. | In the USA, thousands of volunteers are engaged in tracking plant and animal phenology through a variety of citizen science programs for the purpose of amassing spatially and temporally comprehensive datasets useful to scientists and resource managers. The quality of these observations and their suitability for scienti... | 25,179,528 | [
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Effects of temperature on mortality in Hong Kong: a time series analysis. | Although interest in assessing the impacts of hot temperature and mortality in Hong Kong has increased, less evidence on the effect of cold temperature on mortality is available. We examined both the effects of heat and cold temperatures on daily mortality in Hong Kong for the last decade (2002-2011). A quasi-Poisson m... | 25,179,530 | [
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Evaluation of an immunological score to assess the risk of severe infection in heart recipients. | We previously reported how specific humoral and cellular immunological markers that are readily available in clinical practice can be used to identify heart transplant recipients (HTR) at risk of developing severe infections. In this study, we perform an extended analysis to identify immunological profiles that could p... | 25,179,534 | [
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Ellagic acid enhances morphine analgesia and attenuates the development of morphine tolerance and dependence in mice. | According to our previous study, ellagic acid has both dose-related central and peripheral antinociceptive effect through the opioidergic and l-arginine-NO-cGMP-ATP sensitive K(+) channel pathways. In the present study, the systemic antinociceptive effects of ellagic acid in animal models of pain, and functional intera... | 25,179,576 | [
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Defective channels lead to an impaired skin barrier. | Channels are integral membrane proteins that form a pore, allowing the passive movement of ions or molecules across a membrane (along a gradient), either between compartments within a cell, between intracellular and extracellular environments or between adjacent cells. The ability of cells to communicate with one anoth... | 25,179,597 | [
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B56-PP2A regulates motor dynamics for mitotic chromosome alignment. | Proper alignment of duplicated chromosomes at the metaphase plate involves both motor-driven chromosome movement and the functional and physical end-on connection (K-fiber formation) between the kinetochore and the plus-end of microtubules. The B56 family of protein phosphatase 2A (PP2A) regulatory subunits (B56-PP2A),... | 25,179,604 | [
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Revision workshops in elementary mathematics enhance student performance in routine laboratory calculations. | The ability to understand and implement calculations required for molarity and dilution computations that are routinely undertaken in the laboratory are essential skills that should be possessed by all students entering an undergraduate Life Sciences degree. However, it is increasingly recognized that the majority of t... | 25,179,614 | [
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The psychiatric ward as a therapeutic space: systematic review. | Hospital care is still an integral part of mental healthcare services. But the impact of ward design on treatment outcomes is unclear. To review the effects of ward design on patient outcomes and patient and staff well-being. A systematic review of literature was carried out on Medline, Embase and PsycINFO. Papers on p... | 25,179,622 | [
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Cofilin recruits F-actin to SPCA1 and promotes Ca2+-mediated secretory cargo sorting. | The actin filament severing protein cofilin-1 (CFL-1) is required for actin and P-type ATPase secretory pathway calcium ATPase (SPCA)-dependent sorting of secretory proteins at the trans-Golgi network (TGN). How these proteins interact and activate the pump to facilitate cargo sorting, however, is not known. We used pu... | 25,179,631 | [
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Predictive significance of absolute lymphocyte count and morphology in adults with a new onset peripheral blood lymphocytosis. | Lymphocytosis is commonly encountered in the haematology laboratory. Evaluation of blood films is an important screening tool for differentiating between reactive and malignant processes. The optimal lymphocyte number to trigger morphological evaluation of the smear has not been well defined in the literature. Likewise... | 25,179,641 | [
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Exercise equipment preferences among adults with spinal cord injury. | Cross-sectional. To evaluate exercise equipment preferences and compare cardiometabolic demand for passive hybrid and arm-only exercise among adults with paraplegia (PP) and those with tetraplegia (TP). Four community exercise programmes. Thirty-six adults (mean age: 41.1±12.1 years) with chronic (11.4±10.7 years post ... | 25,179,653 | [
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0.0128266... |
Study design to develop and pilot-test a web intervention for partners of military service members with alcohol misuse. | Alcohol misuse among military service members from the recent conflicts in Iraq and Afghanistan is over two times higher compared to misuse in the civilian population. Unfortunately, in addition to experiencing personal consequences from alcohol misuse, partners and family members of alcohol-misusing service members al... | 25,179,672 | [
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EEG biofeedback for autism spectrum disorder: a commentary on Kouijzer et al. (2013). | Research conducted by Kouijzer et al. (Appl Psychophysiol Biofeedback 38(1):17-28, 2013) compared the effects of skin conductance biofeedback and EEG-biofeedback on patients with autistic spectrum disorders to determine their relative efficacy. While they found a difference between treatment and control groups, there w... | 25,179,674 | [
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Resident mesenchymal progenitors of articular cartilage. | Articular cartilage has poor capacity of self-renewal and repair. Insufficient number and activity of resident mesenchymal (connective tissue) progenitors is likely one of the underlying reasons. Chondroprogenitors reside not only in the superficial zone of articular cartilage but also in other zones of articular carti... | 25,179,676 | [
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Glucose increases interleukin-12 gene expression and production in stimulated peripheral blood mononuclear cells of type 2 diabetes patients. | Lipopolysaccharide (LPS)-stimulated peripheral blood mononuclear cells (PBMCs) of type 2 diabetes patients produce more interleukin (IL)-12 under glucose treatment. The aim of this study was to determine whether increased IL-12 response in hyperglycemic LPS-stimulated PBMCs is due to increased gene expression or osmola... | 25,179,705 | [
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... |
Laboratory evaluation of phenotypic detection methods of methicillin-resistant Staphylococcus aureus. | Although conventional antibiotic susceptibility tests are most commonly performed for methicillin-resistant Staphylococcus aureus (MRSA), the results of these phenotypic tests are dependent on the standardization of the culture conditions. The aim of the study was to evaluate the conventional phenotypic screening tests... | 25,179,712 | [
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Impact of the gut microbiota, prebiotics, and probiotics on human health and disease. | Recent studies have revealed that the gut microbiota regulates many physiological functions, ranging from energy regulation and cognitive processes to toxin neutralization and immunity against pathogens. Accordingly, alterations in the composition of the gut microbiota have been shown to contribute to the development o... | 25,179,725 | [
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Activation of the vascular niche supports leukemic progression and resistance to chemotherapy. | Understanding the intricate cellular components of the bone marrow microenvironment can lead to the discovery of novel extrinsic factors that are responsible for the initiation and progression of leukemic disease. We have shown that endothelial cells (ECs) provide a fertile niche that allows for the propagation of prim... | 25,179,751 | [
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Molecular surveillance of pvdhfr, pvdhps, and pvmdr-1 mutations in Plasmodium vivax isolates from Yunnan and Anhui provinces of China. | Plasmodium vivax is the predominant species of human malaria parasites present in China. Although sulphadoxine-pyrimethamine (SP) and chloroquine (CQ) have been widely used for malaria treatment in China, the resistance profiles of these drugs are not available. Analysis of dihydrofolate reductase (dhfr), dihydropteroa... | 25,179,752 | [
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... |
Long-term clinical effects of ventricular pacing reduction with a changeover mode to minimize ventricular pacing in a general pacemaker population. | Right ventricular pacing (VP) has been hypothesized to increase the risk in heart failure (HF) and atrial fibrillation (AF). The ANSWER study evaluated, whether an AAI-DDD changeover mode to minimize VP (SafeR) improves outcome compared with DDD in a general dual-chamber pacemaker population. ANSWER was a randomized co... | 25,179,761 | [
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Successful thrombectomy for coronary embolism likely due to floating aortic plaque in ascending aorta. | A 70-year-old man with chest pain underwent coronary intervention for acute myocardial infarction. We immediately performed coronary thrombectomy with aspiration catheter and collected solid material as a result. After aspiration, we achieved thrombolysis in myocardial infarction trial (TIMI)-flow grade 3 without steno... | 25,179,773 | [
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Obstetrical APS: is there a place for hydroxychloroquine to improve the pregnancy outcome? | The use of the conventional APS treatment (the combination of low-dose aspirin and LMWH) dramatically improved the obstetrical prognosis in primary obstetrical APS (OAPS). The persistence of adverse pregnancy outcome raises the need to find other drugs to improve obstetrical outcome. Hydroxychloroquine is widely used i... | 25,179,813 | [
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A novel minisequencing single-nucleotide polymorphism marker of the lysozyme gene detects high hatchability of Tsaiya ducks (Anas platyrhynchos). | Lysozyme, one of the major albumen antimicrobials, can break down the polysaccharide walls of a broad spectrum of bacteria. This study presents a novel lysozyme marker of high hatchability in the form of minisequencing single-nucleotide polymorphisms (SNPs). Recently, lysozyme was identified by complementary DNA microa... | 25,179,861 | [
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Characterization of Acetobacter pomorum KJY8 isolated from Korean traditional vinegar. | Acetobacter sp. strains were isolated from traditional vinegar collected in Daegu city and Gyeongbuk province. The strain KJY8 showing a high acetic acid productivity was isolated and characterized by phenotypic, chemotaxonomic, and phylogenetic inference based on 16S rRNA sequence analysis. The chemotaxonomic and phyl... | 25,179,899 | [
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0.0504094,
-0.3842805,
0.5075217,
0.2511491,
-0.1592692,
0.4783786,
0.3651096,
-0.2054137,
0.0055949... |
Metabolism of rutin and poncirin by human intestinal microbiota and cloning of their metabolizing α-L-rhamnosidase from Bifidobacterium dentium. | To understand the metabolism of flavonoid rhamnoglycosides by human intestinal microbiota, we measured the metabolic activity of rutin and poncirin (distributed in many functional foods and herbal medicine) by 100 human stool specimens. The average α-Lrhamnosidase activities on the p-nitrophenyl-α-L-rhamnopyranoside, r... | 25,179,902 | [
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... |
Synergistic interaction of Smac mimetic and IFNα to trigger apoptosis in acute myeloid leukemia cells. | Therapeutic targeting of inhibitor of apoptosis (IAP) proteins by small-molecule inhibitors such as Smac mimetic is considered as a promising anticancer strategy to elicit apoptosis. Recent advances have renewed the interest in exploiting the antileukemic activity of interferon (IFN)α for the treatment of acute myeloid... | 25,179,908 | [
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0.1306558,
0.3960166,
0.002749392,
0.06845... |
Pharmacokinetics, pharmacodynamics, and tolerability of single ascending doses of RCT-18 in Chinese patients with rheumatoid arthritis. | RCT-18 is a novel recombinant fusion protein that targets and neutralizes B-lymphocyte stimulator (BLyS) and a proliferation-inducing ligand (APRIL). This first in-human study investigated the safety, tolerability, pharmacokinetics, immunogenicity, and pharmacodynamics of RCT-18 in patients with rheumatoid arthritis (R... | 25,179,916 | [
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0.01237516,
... |
Dental students' glucometer experience and attitudes toward diabetes counseling, monitoring, and screening: a comparative study. | The objectives of this study were to compare glucometer experience and attitudes toward counseling, monitoring, and screening for diabetes between two classes of graduating students at one dental school to determine if there were differences by experience and year of graduation. Dental students graduating in 2010 and 2... | 25,179,922 | [
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0.281600... |
Is off-pump coronary artery bypass surgery superior to on-pump coronary artery bypass surgery on postoperative paradoxical ventricular septal motion? | The aims of this study were to investigate the appearance of paradoxical ventricular septal motion (PSM) after coronary artery bypass graft (CABG) surgery and to identify factors that might be related to this abnormality. This prospective study included 119 consecutive patients (38 women, 81 men) who underwent CABG. Pa... | 25,179,970 | [
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0.1535521,... |
Successful rescue from cardiac arrest in a patient with postinfarction left ventricular blow-out rupture: "extra-pericardial aortic cannulation" for establishment total cardiopulmonary bypass. | We report a quick and simple technique to establish cardiopulmonary bypass (CPB) in a left ventricular (LV) blow-out rupture. A 74-year-old woman with a diagnosis of acute myocardial infarction suddenly collapsed and lost consciousness. A venous-arterial extracorporeal membrane oxygenation (ECMO) device was inserted by... | 25,179,976 | [
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0.1135211,
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0.0927062,
0.01272321,
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0.1074191... |
Motoneuron development influences dorsal root ganglia survival and Schwann cell development in a vertebrate model of spinal muscular atrophy. | Low levels of the survival motor neuron protein (SMN) cause the disease spinal muscular atrophy. A primary characteristic of this disease is motoneuron dysfunction and paralysis. Understanding why motoneurons are affected by low levels of SMN will lend insight into this disease and to motoneuron biology in general. Mot... | 25,180,019 | [
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0.1853662,
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0.2663963,
0.1370173,
0.08512016... |
A DAQ-device-based continuous wave near-infrared spectroscopy system for measuring human functional brain activity. | In the last two decades, functional near-infrared spectroscopy (fNIRS) is getting more and more popular as a neuroimaging technique. The fNIRS instrument can be used to measure local hemodynamic response, which indirectly reflects the functional neural activities in human brain. In this study, an easily implemented way... | 25,180,044 | [
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0.10214,
0.2192792,
0.3361228,
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0.2... |
Detecting ALK, ROS1 and RET Fusion Genes in Cell Block Samples. | Whether Cell block (CB) samples are applicable to detect anaplastic lymphoma kinase (ALK), c-ros oncogene 1 (ROS1) and ret proto-oncogene (RET) fusion genes in lung adenocarcinoma is still unknown. In this study, 108 cytological samples that contained lung adenocarcinoma cells were collected, and made into CB. The CB s... | 25,180,059 | [
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0.149141,
0.4901248,
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Examining Cultural Correlates of Active Coping Among African American Female Trauma Survivors. | African American women are at a greater risk for exposure to multiple traumatic events and are less likely to seek mental health services than White women. Many women report avoidant and passive coping strategies placing them at an increased risk for lower psychological adjustment. Thus, the purpose of the current stud... | 25,180,071 | [
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0.2567054,
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Functional characterization of AT-1001, an α3β4 nicotinic acetylcholine receptor ligand, at human α3β4 and α4β2 nAChR. | Genome-wide association studies linking the α3, β4, and α5 nicotinic acetylcholine receptor (nAChR) subunits to nicotine dependence suggest that α3β4* nAChR may be targets for smoking cessation pharmacotherapies. We previously reported that AT-1001, a selective α3β4* nAChR ligand binds with high affinity to rat α3β4 an... | 25,180,076 | [
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0.3432447,
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0.04968159,
0.2038956,
0.4887188,
-0.04736401,
0... |
Serum Micronutrient Status of Haart-Naïve, HIV Infected Children in South Western Nigeria: A Case Controlled Study. | Background. Though micronutrients are vital in the pathogenesis of human immunodeficiency virus infection, most studies have been conducted in adults. Knowledge of the status of key micronutrients in HIV infected African children will indicate if supplementation may be beneficial to these children living in this resour... | 25,180,086 | [
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0.1443... |
Cross-synaptic synchrony and transmission of signal and noise across the mouse retina. | Cross-synaptic synchrony--correlations in transmitter release across output synapses of a single neuron--is a key determinant of how signal and noise traverse neural circuits. The anatomical connectivity between rod bipolar and A17 amacrine cells in the mammalian retina, specifically that neighboring A17s often receive... | 25,180,102 | [
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0.2001076,
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Coexisting papillary and clear renal cell carcinoma in the same kidney. | Renal cell carcinoma (RCC) is the most common solid lesion of the kidney. Bilateral synchronous benign and malignant renal tumors have been defined in some reports. However, unilateral concordance of malignant renal tumors is very rare and there are only a few cases that had synchronous different subtypes of malignant ... | 25,180,117 | [
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Neurotensin decreases the proinflammatory status of human skin fibroblasts and increases epidermal growth factor expression. | Fibroblasts colonization into injured areas during wound healing (WH) is responsible for skin remodelling and is also involved in the modulation of inflammation, as fibroblasts are immunologically active. Herein, we aimed to determine neurotensin effect on the immunomodulatory profile of fibroblasts, both in homeostati... | 25,180,119 | [
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0.08245514,
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Cardiovascular risk factors and comorbidities in patients with hyperuricemia and/or gout: a systematic review of the literature. | To review the available literature on the likelihood of having cardiovascular (CV) risk factors and on developing CV comorbidities in patients with gout and/or asymptomatic hyperuricemia as an evidence base for generating multinational clinical practice recommendations in the 3e (Evidence, Expertise, Exchange) Initiati... | 25,180,123 | [
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0.2194441,
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0.2456817,
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... |
Knowledge management and safety compliance in a high-risk distributed organizational system. | In a safety perspective, efficient knowledge management is important for learning purposes and thus to prevent errors from occurring repeatedly. The relationship between knowledge exchange among employees and safety behavior may be of particular importance in distributed organizational systems where similar high-risk a... | 25,180,134 | [
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-0.1491984,
0.2153979,
0.1097107,
-0.008346274,
0.5136121,
0.1080186,
-0.1443489,
... |
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