title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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"New designer drugs" in aspects of forensic toxicology. | In autumn of 2010, in response to an ever-increasing market of "new designer drugs" and in view of new legal regulations, the Sanitary Inspection inspected numerous so-called "smart shops" where such products were sold. In the course of mass inspections, 3545 packages of various preparations were secured on the market ... | 25,184,424 | [
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Antimicrobial and anti-biofilm effect of a novel BODIPY photosensitizer against Pseudomonas aeruginosa PAO1. | Photodynamic therapy (PDT) combines the use of organic dyes (photosensitizers, PSs) and visible light in order to elicit a photo-oxidative stress which causes bacterial death. GD11, a recently synthesized PS belonging to the boron-dipyrromethene (BODIPY) class, was demonstrated to be efficient against planktonic cultur... | 25,184,429 | [
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[The social vulnerability index regarding Medellín's disabled population]. | Constructing a social vulnerability index (SVI) for Medellín's disabled population during 2008 aimed at determining areas which were reducing opportunities for this population to use their tangible and intangible assets, thus impairing their quality of life. This descriptive cross-sectional study drew on a source of se... | 25,184,448 | [
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[Stress profile and chronic stress in Mexican immigrants in Canada]. | Establishing an association between high chronic stress levels and variables considered to be negative regarding the stress profile for Mexican migrants living in Edmonton, Canada. A simple random technique was used for choosing the target population; the sample size involved 58 migrants. The Nowack Stress Profile and ... | 25,184,453 | [
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Research opportunities in the area of mental health promotion, prevention, and intervention for children and youth. | The American Occupational Therapy Association (AOTA) Evidence-Based Practice Project has developed a table summarizing the research opportunities on mental health promotion, prevention, and intervention for children and youth. The table provides an overview of the state of current available evidence on interventions wi... | 25,184,474 | [
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Equilibrium sampling to determine the thermodynamic potential for bioaccumulation of persistent organic pollutants from sediment. | Equilibrium partitioning (EqP) theory is currently the most widely used approach for linking sediment pollution by persistent hydrophobic organic chemicals to bioaccumulation. Most applications of the EqP approach assume (I) a generic relationship between organic carbon-normalized chemical concentrations in sediments a... | 25,184,484 | [
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Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation. | Components of the prokaryotic clustered, regularly interspaced, short palindromic repeats (CRISPR) loci have recently been repurposed for use in mammalian cells. The CRISPR-associated (Cas)9 can be programmed with a single guide RNA (sgRNA) to generate site-specific DNA breaks, but there are few known rules governing o... | 25,184,501 | [
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Theoretical studies on the quinoidal thiophene based dyes for dye sensitized solar cell and NLO applications. | A series of quinoidal thiophene based dye molecules were designed and their optoelectronic properties were studied for dye sensitized solar cell (DSSC) applications. The efficiency of the designed dye molecules was analyzed using various parameters such as the HOMO-LUMO energy gap, absorption spectra, light harvesting ... | 25,184,504 | [
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[Organization, availability and possibility of analysis of disaster data of climate related origin and its impacts on health]. | The occurrence of disasters is often related to unforeseeable able natural processes. However, the analysis of major databases may highlight seasonal and long-term trends, as well as some spatial patterns where risks are concentrated. In this paper the process of acquiring and organizing climate-related disaster data c... | 25,184,573 | [
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[Development and validation of a social vulnerability index applied to public policies of the Unified Health System (SUS)]. | The article outlines the development and initial validation of a Social Vulnerability Index (SVI) including five social determinants of risk to health and demonstrates its application in the financing of primary care by the Unified Health System (SUS) in the State of Rio Grande do Sul. Municipal indicators of vulnerabi... | 25,184,590 | [
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An experimental Toxoplasma gondii dose response challenge model to study therapeutic or vaccine efficacy in cats. | High numbers of Toxoplasma gondii oocysts in the environment are a risk factor to humans. The environmental contamination might be reduced by vaccinating the definitive host, cats. An experimental challenge model is necessary to quantitatively assess the efficacy of a vaccine or drug treatment. Previous studies have in... | 25,184,619 | [
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Anterior foregut microbiota of the glassy-winged sharpshooter explored using deep 16S rRNA gene sequencing from individual insects. | The glassy-winged sharpshooter (GWSS) is an invasive insect species that transmits Xylella fastidiosa, the bacterium causing Pierce's disease of grapevine and other leaf scorch diseases. X. fastidiosa has been shown to colonize the anterior foregut (cibarium and precibarium) of sharpshooters, where it may interact with... | 25,184,624 | [
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PEGylated nickel carbide nanocrystals as efficient near-infrared laser induced photothermal therapy for treatment of cancer cells in vivo. | Photothermal therapy has attracted significant attention as a minimally invasive therapy methodology. In this work, we report PEGylated nickel carbide nanocrystals (Ni3C NCs) as an efficient photothermal agent for the first time. The nanoparticles exhibit a broad absorption from the visible to the near-infrared regions... | 25,184,661 | [
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The origins of giant viruses, virophages and their relatives in host genomes. | Giant viruses have revealed a number of surprises that challenge conventions on what constitutes a virus. The Samba virus newly isolated in Brazil expands the known distribution of giant mimiviruses to a near-global scale. These viruses, together with the transposon-related virophages that infect them, pose a number of... | 25,184,667 | [
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A post-translational regulatory switch on UPF1 controls targeted mRNA degradation. | Nonsense-mediated mRNA decay (NMD) controls the quality of eukaryotic gene expression and also degrades physiologic mRNAs. How NMD targets are identified is incompletely understood. A central NMD factor is the ATP-dependent RNA helicase upframeshift 1 (UPF1). Neither the distance in space between the termination codon ... | 25,184,677 | [
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Double-bromo and extraterminal (BET) domain proteins regulate dendrite morphology and mechanosensory function. | A complex array of genetic factors regulates neuronal dendrite morphology. Epigenetic regulation of gene expression represents a plausible mechanism to control pathways responsible for specific dendritic arbor shapes. By studying the Drosophila dendritic arborization (da) neurons, we discovered a role of the double-bro... | 25,184,680 | [
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A Lewis acid-mediated conformational switch. | Molecules that change conformation in response to a stimulus have numerous uses, such as artificial chemoreceptors, novel drug delivery strategies and liquid crystal technology. Here we describe the design, synthesis and conformational behaviour of an isonicotinamide-substituted diphenylacetylene upon recognition of Le... | 25,184,700 | [
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Juvenile psammomatoid ossifying fibroma with massive mandibular involvement. | Juvenile psammomatoid ossifying fibroma (JPOF) is a histologic variant of an ossifying fibroma. While an ossifying fibroma varies in appearance, it consists of fibrocellular tissue and mineralized material. JPOF is a rare benign lesion; however, it can be extended locally and mimic a malignant tumor. It is considered a... | 25,184,712 | [
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A rare case of ankyloglossia and bilateral fusion of mandibular incisors. | Dental anomalies may occur both in primary and permanent dentitions. Abnormalities in tooth size, shape, and structure result from disturbances during the morphodifferentiation stage of development. They are observed frequently during routine dental examinations and might be associated with a syndrome. Dentists must be... | 25,184,721 | [
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Clinicoradiologic features of cherubism: a case report and literature review. | Cherubism is a rare, hereditary, nonneoplastic bone disease. It is characterized by clinically evident bilateral, painless enlargements of the jaws that are said to give the patient a "chubby" appearance. This article presents a case of cherubism in a 5-year-old girl with painless bilateral swelling. Panoramic radiogra... | 25,184,726 | [
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CD39 is a negative regulator of P2X7-mediated inflammatory cell death in mast cells. | Mast cells (MCs) are major contributors to an inflammatory milieu. One of the most potent drivers of inflammation is the cytokine IL-1β, which is produced in the cytoplasm in response to danger signals like LPS. Several controlling mechanisms have been reported which limit the release of IL-1β. Central to this regulati... | 25,184,735 | [
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Efficacy and tolerability of methylprednisolone pulse therapy in childhood epilepsies other than infantile spasms. | This retrospective study included 54 children with epilepsy. The treatment consisted of four pulses with single doses of 20 mg/kg/d methylprednisolone (MPR), administered every week on 3 consecutive days. After this initial phase, the intervals between the pulses were increased based on individual factors. MPR pulses w... | 25,184,741 | [
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Upper esophageal sphincter resting pressure varies during esophageal manometry. | The upper esophageal sphincter is composed of striated muscle. The stress of intubation and the need to inhibit dry swallows during an esophageal manometry test may lead to variations in basal pressure of this sphincter. Upper esophageal sphincter is usually only studied at the final part of the test. Was observed duri... | 25,184,767 | [
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Portal vein embolization using an adapted hysterosalpingography catheter. | Portal vein embolization is an accepted procedure that provides hypertrophy of the future remnant liver in order to reduce post-hepatectomy complications. To present a series submitted to portal vein embolization using an adapted hysterosalpingography catheter via transileocolic route. Were performed right portal branc... | 25,184,773 | [
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Diagnosis and management of gastroesophageal reflux disease. | Gastroesophageal reflux disease (GERD) is probably one of the most prevalent diseases in the world that also compromises the quality of life of the affected significantly. Its incidence in Brazil is 12%, corresponding to 20 million individuals. To update the GERD management and the new trends on diagnosis and treatment... | 25,184,775 | [
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New insights into morphology of high performance BHJ photovoltaics revealed by high resolution AFM. | Direct imaging of the bulk heterojunction (BHJ) thin film morphology in polymer-based solar cells is essential to understand device function and optimize efficiency. The morphology of the BHJ active layer consists of bicontinuous domains of the donor and acceptor materials, having characteristic length scales of severa... | 25,184,797 | [
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Multi-contrast atherosclerosis characterization (MATCH) of carotid plaque with a single 5-min scan: technical development and clinical feasibility. | Multi-contrast weighted imaging is a commonly used cardiovascular magnetic resonance (CMR) protocol for characterization of carotid plaque composition. However, this approach is limited in several aspects including low slice resolution, long scan time, image mis-registration, and complex image interpretation. In this w... | 25,184,808 | [
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Theoretical investigation on multiple bonds in terminal actinide nitride complexes. | A series of actinide (An) species of L-An-N compounds [An = Pa-Pu, L = [N(CH2CH2NSiPr(i)3)3](3-), Pr(i) = CH(CH3)2] have been investigated using scalar relativistic density functional theory (DFT) without considering spin-orbit coupling effects. The ground state geometric and electronic structures and natural bond orbi... | 25,184,822 | [
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In vitro and in vivo antimalarial activity of amphiphilic naphthothiazolium salts with amine-bearing side chains. | Because of emerging resistance to existing drugs, new chemical classes of antimalarial drugs are urgently needed. We have rationally designed a library of compounds that were predicted to accumulate in the digestive vacuole and then decrystallize hemozoin by breaking the iron carboxylate bond in hemozoin. We report the... | 25,184,829 | [
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Effect of commensals and probiotics on visceral sensitivity and pain in irritable bowel syndrome. | The last ten years' wide progress in the gut microbiota phylogenetic and functional characterization has been made evidencing dysbiosis in several gastrointestinal diseases including inflammatory bowel diseases and irritable bowel syndrome (IBS). IBS is a functional gut disease with high prevalence and negative impact ... | 25,184,834 | [
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Feeding zilpaterol hydrochloride is associated with decreased dry matter intake shortly after initiation of feeding dependent on season and previous intake. | A database of daily feed deliveries for steers and heifers fed at 3 commercial feedyards in Kansas between January 1, 2010, and January 31, 2012 (n = 1,515 pens), was used to investigate the prevalence and extent of changes in DMI after initiation of feeding zilpaterol hydrochloride (ZIL) at 8.3 mg/kg (DM) for 20 d. Se... | 25,184,840 | [
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Lenalidomide and dexamethasone in transplant-ineligible patients with myeloma. | The combination melphalan-prednisone-thalidomide (MPT) is considered a standard therapy for patients with myeloma who are ineligible for stem-cell transplantation. However, emerging data on the use of lenalidomide and low-dose dexamethasone warrant a prospective comparison of the two approaches. We randomly assigned 16... | 25,184,863 | [
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Vulvar vitiligo-like depigmentation and multiple halos of hypomelanosis at the trunk following treatment with imiquimod 5% cream for vulvar condylomata: casual or related events? | A 25-year-old Caucasian female with multiple genital warts involving the vulvar area was treated with imiquimod 5% cream. During follow-up the patient developed areas of hypopigmentation at the site of application of imiquimod cream and areas of hypomelanosis around multiple preexisting nevi of the trunk. At 18 months ... | 25,184,923 | [
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Case for diagnosis. | Focal acral hyperkeratosis is a rare genodermatosis with an autosomal dominant pattern of inheritance. It is characterized by usually asymptomatic keratotic papules along the borders of the hands and/or feet. The main differential diagnosis is acrokeratoelastoidosis of Costa, which differs from the former only by not p... | 25,184,932 | [
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Case for diagnosis. | Hansen's disease is a chronic infecto-contagious disease caused by Mycobacterium leprae. The bacillus prefers low-temperature areas and the nose is usually the initial site of lesions. Transmission of the bacilli occurs by nasal and oropharyngeal secretions, and through solutions of continuity of the skin and/or mucosa... | 25,184,933 | [
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Syndrome in question. | Vulvovaginal-gingival syndrome is characterized by erosions and desquamation of the vulva, vagina, and gingiva. We reported a case of a 32-year-old woman presenting with an 8-year history of damage to the vulval and perianal anatomy and limitation of mouth opening. The patient's symptoms were relieved after treatment w... | 25,184,936 | [
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Correlation between psoriasis' severity and waist-to-height ratio. | In the absence of ideal biomarkers, the research for clinical markers correlated to the severity of psoriasis and/or its comorbidities becomes crucial. Recently, studies have shown positive correlation between body mass index and prevalence and severity of psoriasis. Abdominal circumference showed stronger correlation ... | 25,184,937 | [
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Probing occurrence of phenylpropanoids in Morinda citrifolia in relation to foliar diseases. | Accumulation of phenolic compounds in cell walls of different plant organs leading to increased lignification is an early defence response of plants against biotic stress. The aim of this work was to delineate occurrence of cell wall-bound (CWB) phenolic compounds in Morinda citrifolia leaves. Alkaline hydrolysis of th... | 25,184,947 | [
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Resveratrol induces the expression of interleukin-10 and brain-derived neurotrophic factor in BV2 microglia under hypoxia. | Microglia are the resident macrophages of the central nervous system (CNS) and play an important role in neuronal recovery by scavenging damaged neurons. However, overactivation of microglia leads to neuronal death that is associated with CNS disorders. Therefore, regulation of microglial activation has been suggested ... | 25,184,950 | [
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One-step synthesis of 1-chloro-3-arylacetone derivatives from arylacetic acids. | A practical one-step method has been developed to prepare α-chloroketones from readily available, inexpensive phenylacetic acid derivatives. The method utilizes the unique reactivity of an intermediate Mg-enolate dianion, which displays selectivity for the carbonyl carbon of chloromethyl carbonyl electrophiles. Decarbo... | 25,184,954 | [
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Playing nice: improving the professional climate between physicians and midwives in the Calgary area. | Anecdotal reports in the Calgary area indicate a lack of integration of midwives into the mainstream obstetrical community and strained relationships between obstetrical care providers. Finding ways to cultivate positive working relationships is essential for ensuring excellent patient care standards. In this study we ... | 25,184,977 | [
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Kisspeptin induction of somatolactin-α release in goldfish pituitary cells: functional role of cAMP/PKA-, PLC/PKC-, and Ca(2+)/calmodulin-dependent cascades. | Although the importance of kisspeptin in the pituitary is firmly established, the signaling mechanisms for the pituitary actions of kisspeptin are still largely unknown. Somatolactin (SL), a member of the growth hormone (GH)/prolactin (PRL) family, is a pituitary hormone with pleiotropic functions in fish, but its regu... | 25,184,991 | [
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Transcriptional Reprogramming of the Mycoparasitic Fungus Ampelomyces quisqualis During the Powdery Mildew Host-Induced Germination. | Ampelomyces quisqualis is a mycoparasite of a diverse range of phytopathogenic fungi associated with the powdery mildew disease. Among them are several Erysiphaceae species with great economic impact on high-value crops such as grape. Due to its ability to parasitize and prevent the spread of powdery mildews, A. quisqu... | 25,185,010 | [
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Diastereoselective synthesis of substituted tetrahydrofurans via Prins cyclization of enol ethers. | Indium triflate can be efficiently used for Prins cyclization of acrylyl enol ethers to give tetrahydrofuran ring stereo- and regioselectively in good yields. The formation of five-membered rings is against the Baldwin's rule. | 25,185,033 | [
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Lard and/or canola oil-rich diets induce penile morphological alterations in a rat model. | To investigate the effect of dietary lipid quantity and/or quality on penis morphology in adult rats. Thirty-eight male Wistar rats were divided into 4 groups: normal lipid diet (NL), high-fat diet rich in saturated fatty acids (HF-S), high-fat diet rich in polyunsaturated fatty acids (HF-P), and high-fat diet rich in ... | 25,185,055 | [
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Parasiticide resistance in flies, lice and ticks in New Zealand and Australia: mechanisms, prevalence and prevention. | This review outlines the history of parasiticide resistance in the principal ectoparasites of sheep and cattle in New Zealand and Australia, blowflies, buffalo fly (Haematobia irritans exigua), sheep biting louse (Bovicola ovis) and cattle ticks, and discusses recent changes in their response to insecticides and acaric... | 25,185,062 | [
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Antioxidant, antimutagenic, and anticarcinogenic effects of Papaver rhoeas L. extract on Saccharomyces cerevisiae. | The aim of this work was to analyze the antioxidant and antimutagenic/anticarcinogenic capacity of Papaver rhoeas L. water extract against standard mutagen/carcinogen methyl methanesulfonate (MMS) and radiomimetic zeocin (Zeo) on a test system Saccharomyces cerevisiae. The following assays were used: 1,1-diphenyl-2-pic... | 25,185,065 | [
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Electrochemically induced surface metal migration in well-defined core-shell nanoparticles and its general influence on electrocatalytic reactions. | Bimetallic nanoparticle catalysts provide enhanced activity, as combining metals allows tuning of electronic and geometric structure, but the enhancement may vary during the reaction because the nanoparticles can undergo metal migration under catalytic reaction conditions. Using cyclic voltammetry to track the surface ... | 25,185,075 | [
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Toxicity of drinking water disinfection byproducts: cell cycle alterations induced by the monohaloacetonitriles. | Haloacetonitriles (HANs) are a chemical class of drinking water disinfection byproducts (DBPs) that form from reactions between disinfectants and nitrogen-containing precursors, the latter more prevalent in water sources impacted by algae bloom and municipal wastewater effluent discharge. HANs, previously demonstrated ... | 25,185,076 | [
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Risk of subsequent malignant neoplasms in long-term hereditary retinoblastoma survivors after chemotherapy and radiotherapy. | Hereditary retinoblastoma (Rb) survivors have increased risk of subsequent malignant neoplasms (SMNs). Previous studies reported elevated radiotherapy (RT) -related SMN risks, but less is known about chemotherapy-related risks. In a long-term follow-up study of 906 5-year hereditary Rb survivors diagnosed from 1914 to ... | 25,185,089 | [
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Risk of fracture after radical cystectomy and urinary diversion for bladder cancer. | Radical cystectomy and urinary diversion may cause chronic metabolic acidosis, leading to long-term bone loss in patients with bladder cancer. However, the risk of fractures after radical cystectomy has not been defined. We assessed whether radical cystectomy and intestinal urinary diversion are associated with increas... | 25,185,104 | [
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Conceptions of diabetes and diabetes care in young people with minority backgrounds. | Adolescents with type 1 diabetes (T1DM) need stable self-care routines for good metabolic control to minimize future cardiovascular health complications. These routines are demanding, and might be particularly challenging in underprivileged groups. The aim of this study was to gain in-depth knowledge on the experience ... | 25,185,160 | [
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Improved survival ends nivolumab trial early. | A phase III trial testing nivolumab to treat advanced melanoma was stopped early due to improved overall survival compared with standard chemotherapy. | 25,185,170 | [
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Bladder cancers respond to EGFR inhibitors. | Researchers have discovered that nearly 25% of muscle-invasive bladder cancers fall into a "basal-like" subgroup that overexpresses EGFR and other proteins in the same pathway. EGFR inhibitors like erlotinib and cetuximab are effective against basal-like cell lines and tumors implanted into mice, arguing for clinical t... | 25,185,172 | [
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CTCs could guide cancer therapy. | Using a microchip device, scientists were able to capture and culture circulating tumor cells for genetic analysis and drug testing, which identified new tumor mutations that were susceptible to targeted agents. | 25,185,174 | [
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p62 loss reprograms stromal metabolism to promote tumor growth. | p62 deficiency in the tumor microenvironment induces inflammation and prostate tumor progression. | 25,185,199 | [
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Optimizing learning of scientific category knowledge in the classroom: the case of plant identification. | Learning to identify organisms is extraordinarily difficult, yet trained field biologists can quickly and easily identify organisms at a glance. They do this without recourse to the use of traditional characters or identification devices. Achieving this type of recognition accuracy is a goal of many courses in plant sy... | 25,185,226 | [
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Gender gaps in achievement and participation in multiple introductory biology classrooms. | Although gender gaps have been a major concern in male-dominated science, technology, engineering, and mathematics disciplines such as physics and engineering, the numerical dominance of female students in biology has supported the assumption that gender disparities do not exist at the undergraduate level in life scien... | 25,185,231 | [
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Intrastromal femtosecond laser surgical compensation of presbyopia with six intrastromal ring cuts: 3-year results. | To assess over a 36-month period functional results of the modified INTRACOR femtosecond laser-based intrastromal procedure to treat presbyopia. 20 eyes of 20 presbyopic patients with mild hyperopia were included. The INTRACOR procedure with a modified pattern (six concentric intrastromal ring cuts) was performed using... | 25,185,255 | [
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[Efficacy of individualized sublingual immunotherapy with dermatophagoides farinae drops on patients with allergic rhinitis of different age groups]. | To evaluate the efficacy of personal sublingual immunotherapy (SLIT) with dermatophagoides to study the efficacy of dermatophagoides farinae drops for allergic rhinitis (AR) of different age groups. The current study had analyzed the efficacy of SLIT in 150 patients with AR who were sensitized to house dust mites. All ... | 25,185,278 | [
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Norovirus outbreak at a wildland fire base camp ignites investigation of restaurant inspection policies. | Norovirus outbreaks occur worldwide and have been associated with congregate settings (e.g., military and recreational camps). Investigation of a norovirus outbreak at a wildland fire base camp identified 49 (27%) illnesses among approximately 180 responders. Epidemiologic evidence implicated a restaurant as the infect... | 25,185,322 | [
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Oral osteoma in 6 dogs. | Medical records of patients with a histopathological diagnosis of oral osteoma were reviewed for information on signalment, body weight, history, clinical signs, physical examination and diagnostic imaging findings, surgical procedure performed, and histopathologic characteristics. Clinical signs related to the mass we... | 25,185,332 | [
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Effect of ermiao fang with xixin (herba asari mandshurici) on bone marrow stem cell directional homing to a focal zone in an osteoarthritis rat model. | To investigate the effects of Ermiao Fang (EM) with medical guide Xixin (Herba Asari Mandshurici) (HAM) on bone marrow stem cell migration to a focal zone in osteoarthritis (OA) rats. OA rats were induced by arthrectomy and assigned to sham-operated, model, EM, or EM plus HAM groups. All rats were injected with recombi... | 25,185,368 | [
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Potential for Pakistani traditional medicinal plants to combat diabetes. | To investigate the potential of medicinal plants used in traditional healing in Pakistan to inhibit the glycation process. This may be useful in combatting diabetes mellitus and its complications. The in vitro antiglycation activity of 10 medicinal plants was examined by testing the ability of the extracts to inhibit t... | 25,185,369 | [
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An effective utilization of the slag from acid leaching of coal-waste: preparation of water glass with a low-temperature co-melting reaction. | This paper presents an effective utilization of slag from acid leaching of coal-waste with a novel approach, namely low-temperature co-melting method, for preparation of sodium silicate (Na2O x nSiO2) using slag from acid leaching of coal-waste as feedstock. It is very interesting that the co-melting reaction temperatu... | 25,185,391 | [
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A review of the currently recognised zoogonid cercariae, including the identification and emergence ecology of Cercaria capricornia XI (Digenea: Zoogonidae) from Nassarius olivaceus (Gastropoda: Nassariidae) in Central Queensland, Australia. | In the present study, we review the known zoogonid cercariae, summarise their life-cycles and first intermediate host distributions, and present a new cercaria, Cercaria capricornia XI (Digenea: Zoogonidae), which was found in one of three nassariid gastropods, Nassarius olivaceus (Bruguière), surveyed in the intertida... | 25,185,403 | [
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Evaluation of six PCR assays in combination with patient related data for the diagnosis of Clostridium difficile-associated infections. | The aim of this multicenter study was to establish a diagnostic algorithm using molecular methods for the diagnosis of C. difficile-associated infection (CDI). In addition patient specific data were taken into consideration for the interpretation of the results. We compared the performance of six different commercially... | 25,185,420 | [
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Ethamsylate (Dicynone) interference in determination of serum creatinine, uric acid, triglycerides, and cholesterol in assays involving the Trinder reaction; in vivo and in vitro. | The aim of our research was the quantification of interfering properties of the haemostatic drug Dicynone (ethamsylate) in serum creatinine, uric acid, cholesterol, and triglyceride assays using the Trinder reaction. Blood from patients was collected before and 15 minutes after administration of 500 mg Dicynone dose i.... | 25,185,424 | [
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Application of commercial cytomegalovirus IgG avidity diagnostic kit. | In the absence of acute clinical manifestation, the diagnosis of cytomegalovirus (CMV) infection is usually done by serology, which has been an important tool in the clinical medicine. Many commercial CMV IgG avidity kits are available for identification. We decided to evaluate the Autobio Diagnostics Co., Ltd cytomega... | 25,185,425 | [
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Application of immunohistochemistry in the diagnosis of small round blue-cell tumors of soft tissue. | Small round blue-cell tumors (SRBCTs) of soft tissue, which mainly include rhabdomyosarcoma (RMS), synovial sarcoma (SS), and Ewing's sarcoma/peripheral primitive neuroectodermal tumors (EWS/ pPNETs), are malignancies with overlapping morphological and immunohistochemical characteristics. Immunohistochemistry is one of... | 25,185,426 | [
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Analysis of the long control region of bovine papillomavirus type 1 associated with sarcoids in equine hosts indicates multiple cross-species transmission events and phylogeographical structure. | Papillomaviruses are a family of slowly evolving DNA viruses and their evolution is commonly linked to that of their host species. However, whilst bovine papillomavirus-1 (BPV-1) primarily causes warts in its natural host, the cow, it can also cause locally aggressive and invasive skin tumours in equids, known as sarco... | 25,185,436 | [
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The complete mitochondrial genome of Papilio polytes (Lepidoptera Papilionidae). | The complete sequence mitochondrial genome of Papilio polytes was determined using long PCR and conserved primers walking approaches. The genome was 15,260 bp in length and contained 13 protein-coding genes, 2 rRNA genes, 22 tRNA genes and 1 control region (CR). The gene composition and order of P. polytes were similar... | 25,185,455 | [
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The application of advanced oxidation technologies to the treatment of effluents from the pulp and paper industry: a review. | The paper industry is adopting zero liquid effluent technologies to reduce freshwater use and meet environmental regulations, which implies closure of water circuits and the progressive accumulation of pollutants that must be removed before water reuse and final wastewater discharge. The traditional water treatment tec... | 25,185,495 | [
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Am I dyslexic? Parental self-report of literacy difficulties. | In the absence of criteria for the diagnosis of dyslexia, considerable weight is given to self-report, in particular in studies of children at family risk of dyslexia. The present paper uses secondary data from a previous study to compare parents who self-report as dyslexic and those who do not, in relation to objectiv... | 25,185,509 | [
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Widespread transient Hoogsteen base pairs in canonical duplex DNA with variable energetics. | Hoogsteen (HG) base pairing involves a 180° rotation of the purine base relative to Watson-Crick (WC) base pairing within DNA duplexes, creating alternative DNA conformations that can play roles in recognition, damage induction and replication. Here, using nuclear magnetic resonance R1ρ relaxation dispersion, we show t... | 25,185,517 | [
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A new lignan from the roots of Syringa pinnatifolia. | Phytochemical investigation of the roots of Syringa pinnatifolia has resulted in the isolation of a new lignan, pinnatifolin A (1), together with seven known compounds (2-8). The structures were elucidated on the basis of extensive spectroscopic methods, including NMR, MS, UV and IR spectra. The seven lignans were scre... | 25,185,523 | [
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Explicit spatiotemporal simulation of receptor-G protein coupling in rod cell disk membranes. | Dim-light vision is mediated by retinal rod cells. Rhodopsin (R), a G-protein-coupled receptor, switches to its active form (R(∗)) in response to absorbing a single photon and activates multiple copies of the G-protein transducin (G) that trigger further downstream reactions of the phototransduction cascade. The classi... | 25,185,540 | [
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Reduction of the peptidoglycan crosslinking causes a decrease in stiffness of the Staphylococcus aureus cell envelope. | We have used atomic-force microscopy (AFM) to probe the effect of peptidoglycan crosslinking reduction on the elasticity of the Staphylococcus aureus cell wall, which is of particular interest as a target for antimicrobial chemotherapy. Penicillin-binding protein 4 (PBP4) is a nonessential transpeptidase, required for ... | 25,185,544 | [
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Surfactant bilayers maintain transmembrane protein activity. | In vitro studies of membrane proteins are of interest only if their structure and function are significantly preserved. One approach is to insert them into the lipid bilayers of highly viscous cubic phases rendering the insertion and manipulation of proteins difficult. Less viscous lipid sponge phases are sometimes use... | 25,185,548 | [
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Tethered fluorophore motion: studying large DNA conformational changes by single-fluorophore imaging. | We have previously introduced tethered fluorophore motion (TFM), a single-molecule fluorescence technique that monitors the effective length of a biopolymer such as DNA. TFM uses the same principles as tethered particle motion (TPM) but employs a single fluorophore in place of the bead, allowing TFM to be combined with... | 25,185,556 | [
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... |
Cryptic iridescence in a fossil weevil generated by single diamond photonic crystals. | Nature's most spectacular colours originate in integumentary tissue architectures that scatter light via nanoscale modulations of the refractive index. The most intricate biophotonic nanostructures are three-dimensional crystals with opal, single diamond or single gyroid lattices. Despite intense interest in their opti... | 25,185,581 | [
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An extracellular polymer at the interface of magnetic bioseparations. | FucoPol, a fucose-containing extracellular polysaccharide (EPS) produced by bacterium Enterobacter A47 using glycerol as the carbon source, was employed as a coating material for magnetic particles (MPs), which were subsequently functionalized with an artificial ligand for the capture of antibodies. The performance of ... | 25,185,582 | [
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Medication effects on periurethral sensation and urethral sphincter activity. | The aim of this study was to characterize urethral neuromuscular function before and 2 weeks after medication therapy. Premenopausal women without lower urinary tract symptoms were randomly allocated to 1 of the 6 medications for 2 weeks (pseudoephedrine ER of 120 mg, imipramine of 25 mg, cyclobenzaprine of 10 mg, tams... | 25,185,603 | [
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0.03346577,
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0.07440471,
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0.08918153,
0.15197... |
Nephrogenic adenoma in a urethral diverticulum. | Nephrogenic adenoma (NA) is a rare finding that represents metaplasia of the urothelium. We present a case of a 46-year-old woman who presented with a symptomatic anterior vaginal wall cyst that was found to be an NA within a urethral diverticulum. Although this remains an infrequently reported entity in the literature... | 25,185,615 | [
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0.17... |
Prevalence and correlates of urinary incontinence among older community-dwelling women. | As the aging population in the United States grows, the investigation of urinary incontinence (UI) issues becomes increasingly important, especially among women. Using data from the California Health Interview Survey (CHIS), we sought to determine the prevalence and correlates of UI among an ethnically diverse populati... | 25,185,631 | [
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0.1716635,
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An update on the medical treatment of Graves' hyperthyroidism. | Medical treatment of Graves' hyperthyroidism is based on the use of thionamides; namely, methimazole and propylthiouracil. In the past, methimazole was preferred by European endocrinologists, whereas propylthiouracil was the first choice for the majority of their North American colleagues. However, because of the recen... | 25,185,644 | [
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The association of cytotoxic T-lymphocyte antigen-4 + 49A/G and CT60 polymorphisms with type 1 diabetes and latent autoimmune diabetes in Chinese adults. | The aim of this study was to investigate the association of cytotoxic T-lymphocyte antigen-4 (CTLA-4) + 49A/G and CT60 polymorphisms with latent autoimmune diabetes in adults (LADA) and the genetic differences between LADA, type 1 diabetes (T1DM), and type 2 diabetes (T2DM) in a Chinese population. A total of 231 LADA,... | 25,185,645 | [
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Viral infection risks for patients using the finished product Hirudo verbana (medicinal leech). | The virological safety of medicinal leeches has to be ensured prior to their use on patients. While leeches can be kept and bred under standardized conditions, feeding them horse blood adds a non-standardized component, which poses some risk of infection of the treated patients. Here, we investigated the speed at which... | 25,185,664 | [
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Inflammatory bowel disease cause-specific mortality: a primer for clinicians. | Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC) is perceived to harbor significant morbidity but limited excess mortality, thought to be driven by colon cancer, compared with the general population. Recent studies suggest mortality rates seem higher than previously understoo... | 25,185,685 | [
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The search for the most stable structures of silicon-carbon monolayer compounds. | The most stable structures of two-dimensional (2D) silicon-carbon monolayer compounds with different stoichiometric compositions (i.e., Si : C ratio = 2 : 3, 1 : 3 and 1 : 4) are predicted for the first time based on the particle-swarm optimization (PSO) technique combined with density functional theory optimization. A... | 25,185,699 | [
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Recognition of concanavalin A by cationic glucosylated liposomes. | The specificity of carbohydrate-lectin interaction has been reported as an attractive strategy for drug delivery in cancer therapy because of the high levels of lectins in several human malignancies. A novel cationic glucosylated amphiphile was therefore synthesized, as a model system, to attribute specificity toward d... | 25,185,719 | [
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0.4257585,
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Metabolic Free Energy and Biological Codes: A 'Data Rate Theorem' Aging Model. | A famous argument by Maturana and Varela (Autopoiesis and cognition. Reidel, Dordrecht, 1980) holds that the living state is cognitive at every scale and level of organization. Since it is possible to associate many cognitive processes with 'dual' information sources, pathologies can sometimes be addressed using statis... | 25,185,747 | [
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0.15685,
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0.5553884,
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Distribution, abundance and traditional management of Agave potatorum in the Tehuacán Valley, Mexico: bases for sustainable use of non-timber forest products. | Agave species have been used for thousands of years in the Tehuacán Valley, but the current mescal production has great impact on populations of the most used species. Harvesting of A. potatorum takes place before sexual reproduction and the over-extraction put local populations at high risk. In the community of San Lu... | 25,185,769 | [
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Design, synthesis and herbicidal activity of novel quinazoline-2,4-diones as 4-hydroxyphenylpyruvate dioxygenase inhibitors. | 4-Hydroxyphenylpyruvate dioxygenase (HPPD) (EC 1.13.11.27) has been identified as one of the most promising target sites for herbicide discovery. To discover novel HPPD inhibitors with high herbicidal activity and improved crop selectivity, a series of novel triketone-containing quinazoline-2,4-dione derivatives posses... | 25,185,782 | [
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0.1019475,
0.05681467,
0.6780341,
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Patients' perceived level of social isolation affects the prognosis of low back pain. | Perceived social isolation is prevalent among patients with low back pain (LBP) and could be a potential prognostic factor for clinical outcomes following an episode of LBP. A secondary analysis of an original prospective cohort study, which investigated the validity of the Danish version of the STarT Back Screening To... | 25,185,789 | [
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0.3454541,
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0.008776083,
... |
Recombinant Lactococcus lactis can make the difference in antigen-specific immune tolerance induction, the Type 1 Diabetes case. | Especially in western civilizations, immune diseases that are driven by innocuous (auto- or allo-) antigens are gradually evolving to become pandemic threats. A particularly poignant example is type 1 diabetes, where young children are confronted with the perspective and consequences of total pancreatic β-cell destruct... | 25,185,797 | [
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Activation of rostral ventromedial medulla neurons by noxious stimulation of cutaneous and deep craniofacial tissues. | The rostral ventromedial medulla (RVM) projects to the medullary and spinal dorsal horns and is a major source of descending modulation of nociceptive transmission. Traditionally, neurons in the RVM are classified functionally as on, off, and neutral cells on the basis of responses to noxious cutaneous stimulation of t... | 25,185,804 | [
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Mathematical analysis of depolarization block mediated by slow inactivation of fast sodium channels in midbrain dopamine neurons. | Dopamine neurons in freely moving rats often fire behaviorally relevant high-frequency bursts, but depolarization block limits the maximum steady firing rate of dopamine neurons in vitro to ∼10 Hz. Using a reduced model that faithfully reproduces the sodium current measured in these neurons, we show that adding an addi... | 25,185,810 | [
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Intelligence moderates reinforcement learning: a mini-review of the neural evidence. | Our understanding of the neural basis of reinforcement learning and intelligence, two key factors contributing to human strivings, has progressed significantly recently. However, the overlap of these two lines of research, namely, how intelligence affects neural responses during reinforcement learning, remains uninvest... | 25,185,818 | [
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Temperature-dependent stability of stacking faults in Al, Cu and Ni: first-principles analysis. | We present comparative analysis of microscopic mechanisms relevant to plastic deformation of the face-centered cubic (FCC) metals Al, Cu, and Ni, through determination of the temperature-dependent free energies of intrinsic and unstable stacking faults along [1 1̄ 0] and [1 2̄ 1] on the (1 1 1) plane using first-princi... | 25,185,834 | [
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-0.1310411,
0.5100692,
0.3826083,
0.1677628,
-0.39478... |
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