title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Long-term outcome after overlapping anterior anal sphincter repair for fecal incontinence. | The aim was to assess long-term results and quality of life following anterior anal sphincter repair for anal incontinence. Twenty-three female patients underwent anterior anal sphincteroplasty over a 10-year period between January 1999 and January 2009 in a gynecological surgery department. Patients were asked to comp... | 25,185,844 | [
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Hyperthyroidism during pregnancy--the role of measuring maternal TSH receptor antibodies and foetal ultrasound monitoring. | To evaluate the usefulness of measuring maternal anti-TSH receptor antibodies (TRAbs) and foetal ultrasound (US) monitoring in cases of current or past maternal hyperthyroidism. 77 pregnant women suffering from hyperthyroidism or with a history of Graves' hyperthyroidism were observed prospectively. Maternal serum TSH,... | 25,185,847 | [
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The effect of short-term combined treatment with simvastatin and ezetimibe on circulating adipokine levels in patients with isolated hypercholesterolemia. | Although several studies have assessed plasma adipokines in patients treated with hypolipidemic agents, these studies have provided contrasting results. This study included 19 high-risk patients with elevated total and LDL cholesterol levels treated with simvastatin (40 mg daily) and ezetimibe (10 mg daily). Plasma lev... | 25,185,849 | [
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Activated protein C to heal pressure ulcers. | Pressure ulcers present a major clinical challenge, are physically debilitating and place the patient at risk of serious comorbidities such as septic shock. Recombinant human activated protein C (APC) is an anticoagulant with anti-inflammatory, cytoprotective and angiogenic effects that promote rapid wound healing. Top... | 25,185,858 | [
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Plasma levels of fibroblast growth factor-23 are associated with muscle mass in haemodialysis patients. | Malnutrition is highly prevalent in haemodialysis (HD) patients, and it contributes to morbidity and mortality. Fibroblast growth factor-23 (FGF-23) and Klotho contribute to chronic kidney disease-mineral and bone disorder (CKD-MBD) in HD patients, but the role that these molecules play in determining nutritional statu... | 25,185,859 | [
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Gyrodactylus gasterostei a difficult meal to swallow for the three-spined sticklebacks, Gasterosteus aculeatus L. | This study examines the transmission strategies employed by parasites in order to colonize new hosts. Three-spined sticklebacks, Gasterosteus aculeatus L., were challenged with Gyrodactylus gasterostei Gläser, 1974 in a chamber and the colonization of new hosts was observed. Live-video recording indicates that gyrodact... | 25,185,879 | [
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The complete mitochondrial genome of malbrouck monkey, Chlorocebus cynosuros (Chlorocebus, Cercopithecinae). | In this study, the complete mitochondrial genome sequence of malbrouck monkey, Chlorocebus cynosuros, with the total length of 16,334 bp, is reported for the first time. Similar to other monkeys, it contains a typically conserved structure including 13 protein-coding genes, 22 transfer RNA genes, 2 ribosomal RNA genes,... | 25,185,937 | [
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Transparent nickel selenide alloy counter electrodes for bifacial dye-sensitized solar cells exceeding 10% efficiency. | In the current work, we report a series of bifacial dye-sensitized solar cells (DSSCs) that provide power conversion efficiencies of more than 10% from bifacial irradiation. The device comprises an N719-sensitized TiO2 anode, a transparent nickel selenide (Ni-Se) alloy counter electrode (CE), and liquid electrolyte con... | 25,185,939 | [
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Detection of occult hepatitis C virus among healthy spouses of patients with HCV infection. | The criterion standard for the diagnosis of occult hepatitis C virus (HCV) infection is detection of HCV-RNA in liver cells. However, because of the invasive nature of liver biopsy, other methods have been studied. The present study aimed to identify subjects with occult HCV-4 infection among healthy sexual partners of... | 25,185,940 | [
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Modification of silicone elastomer with zwitterionic silane for durable antifouling properties. | Biofouling on medical devices generally causes adverse complications, such as thrombosis, infection, and pathogenic calcification. Silicone is a widely used material for medical applications. Its surface modification typically encounters undesirable "hydrophobic recovery", leading to deterioration of surface engineerin... | 25,185,951 | [
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Predicting well-being longitudinally for mothers rearing offspring with intellectual and developmental disabilities. | Well-being outcomes for parents of children with intellectual and developmental disabilities (IDD) may vary from positive to negative at different times and for different measures of well-being. Predicting and explaining this variability has been a major focus of family research for reasons that have both theoretical a... | 25,185,956 | [
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Impact of age on early outcome after coronary bypass graft surgery using minimized versus conventional extracorporeal circulation. | Objective of this study was to evaluate the impact of age on comparative early outcomes after coronary artery bypass graft surgery (CABG) with minimized (MECC) and conventional extracorporeal circulation (CECC). A retrospective age-, gender- and operation-matched cohort analysis between January 2005 and December 2010 w... | 25,185,963 | [
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Diabetes mellitus type 2 and functional foods of plant origin. | Diabetes is the common, exponentially growing, serious human health problem existing globally. Risk factors like genetic predisposition, lack of balanced diet, inappropriate and lethargic lifestyle, overweight, obesity, stress including emotional and oxidative and lack of probiotics in gut are found to be the causing f... | 25,185,980 | [
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Patents in therapeutic recombinant protein production using mammalian cells. | The industrial production of recombinant proteins preferentially requires the generation of stable cell lines expressing proteins in a quick, relatively facile, and a reproducible manner. Different methods are used to insert exogenous DNA into the host cell, and choosing the appropriate producing cell is of paramount i... | 25,185,983 | [
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Pharmacogenomic considerations in the treatment of the pediatric cardiomyopathy called Barth syndrome. | Barth syndrome (BTHS) is a genetic, X-linked, rare but often fatal, pediatric skeletal- and cardiomyopathy occurring due to mutations in the tafazzin gene (TAZ). TAZ encodes a transacylase involved in phospholipid biosynthesis, also called tafazzin, which is responsible for remodeling the inner mitochondrial membrane p... | 25,185,984 | [
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Pharmacogenomics in psychiatry: implications for practice. | Psychotropic medications are used for numerous psychiatric and neurologic disorders, and are associated with in some cases life-threatening adverse effects, high acquisition costs, stringent monitoring requirements, and potential interactions with other medications. Because of the risks of adverse effects and need for ... | 25,185,985 | [
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Obstacles to precision oncology: confronting current factors affecting the successful introduction of biomarkers to the clinic. | Tailoring treatment strategies to individual patients requires the availability of reliable biomarkers. Despite important investment in biomarker research, few examples of successful biomarker-drug co-development are currently seen in clinical practice. The validity of a biomarker measurement may be affected by differe... | 25,185,990 | [
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Final thermal conditions override the effects of temperature history and dispersal in experimental communities. | Predicting the effect of climate change on biodiversity is a multifactorial problem that is complicated by potentially interactive effects with habitat properties and altered species interactions. In a microcosm experiment with communities of microalgae, we analysed whether the effect of rising temperature on diversity... | 25,186,000 | [
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Human embryonic stem cells prevent T-cell activation by suppressing dendritic cells function via TGF-beta signaling pathway. | Human embryonic stem cells (hESCs) represent a potential source of transplantable cells for regenerative medicine, but development of teratoma even in syngenic recipients represents a critical obstacle to safe stem cell-based therapies. We hypothesized that hESCs escape the immune surveillance by regulating the environ... | 25,186,014 | [
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Numerical modelling of the groundwater inflow to an advancing open pit mine: Kolahdarvazeh pit, Central Iran. | The groundwater inflow into a mine during its life and after ceasing operations is one of the most important concerns of the mining industry. This paper presents a hydrogeological assessment of the Irankuh Zn-Pb mine at 20 km south of Esfahan and 1 km northeast of Abnil in west-Central Iran. During mine excavation, the... | 25,186,026 | [
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Evaluation and validation of biochip multi-array technology for the screening of six families of antibiotics in honey according to the European guideline for the validation of screening methods for residues of veterinary medicines. | The main chemicals used against varoa are acaricides, and the antibiotics used for the control of bee bacterial diseases are mainly tetracyclines, streptomycins, sulfonamides and chloramphenicol. No maximum residue limits (MRLs) have been set for any antibiotics in honey. Therefore, in the European Union, minimum recom... | 25,186,037 | [
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Evaluation of the formation of volatiles and sensory characteristics of persimmon (Diospyros kaki L.f.) fruit wines using different commercial yeast strains of Saccharomyces cerevisiae. | This study evaluated the effects of five strains (IFFI 1346, IFFI 1363, CICC 31482, D254 and CGMCC2.346) of the yeast Saccharomyces cerevisiae on the aromatic profiles of fermented persimmon (Diospyros kaki L.f.) musts. A total of 50 and 60 compounds were identified in persimmon wine by stir bar sorptive extraction cou... | 25,186,058 | [
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The effectiveness of skeletal imaging for quality assessment in posterior cruciate ligament reconstruction: reliability and validity of radiographs and computed tomography. | For intra- and postoperative evaluation of precise and anatomic graft tunnel position, radiographs (XR) and computed tomography (CT) scans have been suggested. The purpose of this study was to evaluate the reliability and validity of XR and CT for quality assessment following PCL reconstruction. Postoperative radiograp... | 25,186,075 | [
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Postoperative wound dealing and superficial surgical site infection in open radical prostatectomy. | The number of open radical prostatectomy (RP) surgeries has been decreasing owing to the spread of laparoscopic and robotic surgery, which has implications for postoperative wound healing. The purpose of this study was to investigate and document the current status of postoperative wound healing and superficial surgica... | 25,186,077 | [
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Matriptase and MET are prominently expressed at the site of bone metastasis in renal cell carcinoma: immunohistochemical analysis. | High MET expression in renal cell carcinoma (RCC) and MET activation in bone metastases are reportedly important in progression of several cancers. To find new treatment targets in bone metastasis, we immunohistochemically analyzed expression levels of MET and matriptase (specific cellular activator of hepatocyte growt... | 25,186,085 | [
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Prognostic value of liver fibrosis and steatosis biomarkers in type-2 diabetes and dyslipidaemia. | In cardiometabolic disorders, non-alcoholic fatty liver disease is frequent and presumably associated with increased mortality and cardiovascular risk. To evaluate the prognostic value of non-invasive biomarkers of liver fibrosis (FibroTest) and steatosis (SteatoTest) in patients with type-2 diabetes and/or dyslipidaem... | 25,186,086 | [
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Gamma Knife radiosurgery for meningiomas arising from the tentorium: a 22-year experience. | In order to evaluate long term clinical and imaging outcomes, the authors retrospectively reviewed our 22-year experience using stereotactic radiosurgery (SRS) for tentorial meningiomas. Thirty-nine patients with tentorial meningiomas underwent SRS using various Gamma Knife technologies between 1988 and 2010. The most ... | 25,186,087 | [
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Immunophenotyping does not improve predictivity of the local lymph node assay in mice. | The local lymph node assay (LLNA) is a regulatory accepted test for the identification of skin sensitizing substances by measuring radioactive thymidine incorporation into the lymph node. However, there is evidence that LLNA is overestimating the sensitization potential of certain substance classes in particular those ... | 25,186,098 | [
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0.5823289,
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Immunohistochemical evidence for the association between attenuated mTOR signaling and diffuse alveolar damage, a fatal lung complication. | Targeted anticancer therapies have been developed to interfere with specific target molecules including those of downstream pathways required for tumor growth and progression. Mammalian target of rapamycin (mTOR) has been considered as one of the target molecules of cancer growth, and its inhibitors have been reported ... | 25,186,104 | [
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Uricaemia and left ventricular mass in hypertensive patients. | Both hyperuricaemia and left ventricular (LV) hypertrophy are associated with the metabolic syndrome and increased cardiovascular risk. The relationship between uric acid levels and left ventricular mass in hypertension, however, is unclear. In this study, we have investigated this relationship in hypertensive patients... | 25,186,106 | [
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The threat of Asian dust storms on asthma patients: a population-based study in Taiwan. | This study explores the relationship between Asian dust storms (ADSs), asthma hospital admissions and average medical cost discharge. We adopt the hospitalisation data from the Taiwan National Health Insurance research database covering the period from 2000 to 2009. The autoregressive integrated moving average with exo... | 25,186,129 | [
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Variation in the recording of common health conditions in routine hospital data: study using linked survey and administrative data in New South Wales, Australia. | To investigate the nature and potential implications of under-reporting of morbidity information in administrative hospital data. Retrospective analysis of linked self-report and administrative hospital data for 32,832 participants in the large-scale cohort study (45 and Up Study), who joined the study from 2006 to 200... | 25,186,157 | [
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Expression of tomato SlTIP2;2 enhances the tolerance to salt stress in the transgenic Arabidopsis and interacts with target proteins. | Three independent transgenic Arabidopsis lines expressing SlTIP2;2 from Solanum lycopersicum L. cv. Lichun under the control of its endogenous promoter were used to analyze the expression of SlTIP2;2 and the salt stress tolerance under NaCl concentration gradient treatment. The expression patterns of SlTIP2;2 were show... | 25,186,161 | [
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Factors associated with the timing and onset of cannabis use and cannabis use disorder: results from the 2007 Australian National Survey of Mental Health and Well-Being. | To investigate the predictors of both initiation of cannabis use and transition to cannabis use disorder (CUD) in a nationally representative sample using discrete-time survival analyses. Data from a nationally representative sample of 6935 Australian adults. Retrospective data on age of first cannabis use and onset of... | 25,186,194 | [
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0.034... |
The interaction of N-trifluoroacetylgalactosamine and its derivatives with winged bean (Psophocarpus tetragonolobus) basic agglutinin reveals differential mechanism of their recognition: a fluorine-19 nuclear magnetic resonance study. | Here, we show the binding results of a leguminosae lectin, winged bean basic agglutinin (WBA I) to N-trifluoroacetylgalactosamine (NTFAGalN), methyl-α-N-trifluoroacetylgalactosamine (MeαNTFAGalN) and methyl-β-tifluoroacetylgalactosamine (MeβNTFAGalN) using (19) F NMR spectroscopy. No chemical shift difference between t... | 25,186,197 | [
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Mitochondrial tRNAThr 15891C>G mutation was not associated with Leber's hereditary optic neuropathy in Han Chinese patients. | Mutations in mitochondrial DNA (mtDNA) were the most important causes of Leber's hereditary optic neuropathy (LHON). To date, approximately 25 LHON-associated mtDNA mutations have been identified in various ethnic populations. Three primary mutations, the 3460G > A, 11778G > A and 14484T > C, in genes encoding... | 25,186,221 | [
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Modern network science of neurological disorders. | Modern network science has revealed fundamental aspects of normal brain-network organization, such as small-world and scale-free patterns, hierarchical modularity, hubs and rich clubs. The next challenge is to use this knowledge to gain a better understanding of brain disease. Recent developments in the application of ... | 25,186,238 | [
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Improved bioethanol production in an engineered Kluyveromyces lactis strain shifted from respiratory to fermentative metabolism by deletion of NDI1. | In this paper, we report the metabolic engineering of the respiratory yeast Kluyveromyces lactis by construction and characterization of a null mutant (Δklndi1) in the single gene encoding a mitochondrial alternative internal dehydrogenase. Isolated mitochondria of the Δklndi1 mutant show unaffected rate of oxidation o... | 25,186,243 | [
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Current situation and challenge of registry in China. | Increasing emphasis has been placed on registries for an organized system used in developing clinical research to improve health care. China has sufficient data that can be applied broadly, but the heterogeneity and irregularity of registries limit their applicability. This article aims to describe the status of regist... | 25,186,248 | [
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Diagnosis of subarachnoid haemorrhage: a survey of Australasian emergency physicians and trainees. | This study aims to establish current practice among Australasian emergency physicians and trainees on several aspects of the investigation of suspected subarachnoid haemorrhage (SAH). An electronic questionnaire (SurveyMonkey™) was distributed to emergency physicians and trainees by email through the ACEM. Survey recip... | 25,186,282 | [
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Health & Demographic Surveillance System profile: the Muzaffarpur-TMRC Health and Demographic Surveillance System. | The Muzaffarpur-TMRC Health and Demographic Surveillance System (HDSS), established in 2007, was developed as an enlargement of the scope of a research collaboration on the project Visceral Leishmaniasis in Bihar, which had been ongoing since 2005. The HDSS is located in a visceral leishmaniasis (VL)-endemic area in th... | 25,186,307 | [
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The kynurenine pathway of tryptophan degradation is activated during osteoblastogenesis. | The mechanisms involved in the anabolic effect of interferon gamma (IFNγ) on bone have not been carefully examined. Using microarray expression analysis, we found that IFNγ upregulates a set of genes associated with a tryptophan degradation pathway, known as the kynurenine pathway, in osteogenic differentiating human m... | 25,186,311 | [
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Schedule Control and Nursing Home Quality: Exploratory Evidence of a Psychosocial Predictor of Resident Care. | To examine whether nursing homes' quality of care was predicted by schedule control (workers' ability to decide work hours), independently of other staffing characteristics. Prospective ecological study of 30 nursing homes in New England. Schedule control was self-reported via survey in 2011-2012 (N = 1,045). Quality m... | 25,186,313 | [
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Ocular pulse amplitude and retinal vessel caliber changes after intravitreal ranibizumab. | The purpose of the present study was to examine the effects of intravitreal ranibizumab on ocular pulse amplitude (OPA) and retinal vessel caliber (RVC) in wet age-related macular degeneration (AMD). Thirty-two eyes of 32 wet AMD patients were included in this case series. Three consecutive monthly injections of ranibi... | 25,186,317 | [
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Image-guided transorbital procedures with endoscopic video augmentation. | Surgical interventions to the orbital space behind the eyeball are limited to highly invasive procedures due to the confined nature of the region along with the presence of several intricate soft tissue structures. A minimally invasive approach to orbital surgery would enable several therapeutic options, particularly n... | 25,186,388 | [
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Characteristic performance evaluation of a photon counting Si strip detector for low dose spectral breast CT imaging. | The possible clinical applications which can be performed using a newly developed detector depend on the detector's characteristic performance in a number of metrics including the dynamic range, resolution, uniformity, and stability. The authors have evaluated a prototype energy resolved fast photon counting x-ray dete... | 25,186,390 | [
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Reduction of ring artifacts in CBCT: detection and correction of pixel gain variations in flat panel detectors. | In using flat panel detectors (FPD) for cone beam computed tomography (CBCT), pixel gain variations may lead to structured nonuniformities in projections and ring artifacts in CBCT images. Such gain variations can be caused by change in detector entrance exposure levels or beam hardening, and they are not accounted by ... | 25,186,400 | [
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Dose response of selected solid state detectors in applied homogeneous transverse and longitudinal magnetic fields. | MR-Linac devices under development worldwide will require standard calibration, commissioning, and quality assurance. Solid state radiation detectors are often used for dose profiles and percent depth dose measurements. The dose response of selected solid state detectors is therefore evaluated in varying transverse and... | 25,186,403 | [
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A mapping of people's positions regarding the breaking of bad news to patients. | The objective of this study was to map people's positions regarding the breaking of bad news to patients. One hundred forty adults who had in the past received bad medical news or whose elderly relatives had in the past received bad news, 25 nurses, and 28 nurse's aides indicated the acceptability of physicians' conduc... | 25,186,427 | [
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11C-Choline PET/pathology image coregistration in primary localized prostate cancer. | The aim of this study was to develop a methodology for the comparison of pathology specimens after prostatectomy (post-S) with PET images obtained before surgery (pre-S). This method was used to evaluate the merit of (11)C-choline PET/CT for delineation of gross tumour volume (GTV) in prostate cancer (PC). In 28 PC pat... | 25,186,430 | [
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Influence of valve size, orientation and downstream geometry of an aortic BMHV on leaflet motion and clinically used valve performance parameters. | The aim of this study was to reconcile some of our own previous work and the work of others to generate a physiologically realistic numerical simulation environment that allows to virtually assess the performance of BMHVs. The model incorporates: (i) a left ventricular deformable model to generate a physiological inflo... | 25,186,435 | [
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0.3... |
Model-based approach to early predict prolonged high grade neutropenia in carboplatin-treated patients and guide G-CSF prophylactic treatment. | Neutropenia is a major dose-limiting side effect of chemotherapy and is closely related to febrile neutropenia which mainly occurs during the first cycle. Our objectives were to establish model-based decision rules from early absolute neutrophil counts (ANC) to anticipate prolonged high grade neutropenia at cycle 1 and... | 25,186,439 | [
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Diagnostic angiography skill acquisition with a secondary curve catheter: phase 2 of a curriculum-based endovascular simulation program. | We have previously reported the efficacy of a simulator-based training paradigm for residents in neurosurgery with little or no prior experience in diagnostic cerebral angiography with straightfoward arch anatomy. This study investigates the utility of a simulation-based training curriculum for the acquisition of skill... | 25,186,445 | [
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Genetic covariance between components of male reproductive success: within-pair vs. extra-pair paternity in song sparrows. | The evolutionary trajectories of reproductive systems, including both male and female multiple mating and hence polygyny and polyandry, are expected to depend on the additive genetic variances and covariances in and among components of male reproductive success achieved through different reproductive tactics. However, ... | 25,186,454 | [
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... |
Deletion of the α2A/α2C-adrenoceptors accelerates cutaneous wound healing in mice. | The α2-adrenoceptors regulate the sympathetic nervous system, controlling presynaptic catecholamine release. However, the role of the α2-adrenoceptors in cutaneous wound healing is poorly understood. Mice lacking both the α2A/α2C-adrenoceptors were used to evaluate the participation of the α2-adrenoceptor during cutane... | 25,186,490 | [
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0.01536866,
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Diagnostic and predictive performance and standardized threshold of traditional biomarkers for drug-induced liver injury in rats. | Traditional biomarkers such as alanine and aspartate aminotransferase (ALT, AST) and total bilirubin (TBIL) have been widely used for detecting drug-induced liver injury (DILI). Although the Food and Drug Administration (FDA) proposed standardized thresholds for human as Hy's law, those for animals have not been determ... | 25,186,495 | [
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Influence of substrate steps on the catalytic properties of Pt layers: the ethanol electrooxidation reaction. | The ethanol oxidation reaction (EOR) is investigated on Pt/Au(hkl) electrodes. The Au(hkl) single crystals used belong to the [n(111)x(110)] family of planes. Pt is deposited following the galvanic exchange of a previously deposited Cu monolayer using a Pt(2+) solution. Deposition is not epitaxial and the defects on th... | 25,186,523 | [
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Are personality traits associated with white-coat and masked hypertension? | Anxiety and other psychological dispositions are thought to be associated with blood pressure. This study tests whether personality traits have long-term associations with masked and white-coat effects. A community-based sample of 2838 adults from Sardinia (Italy) completed the Revised NEO Personality Inventory, and 7 ... | 25,186,529 | [
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Use of biomarker S100B for traumatic brain damage in the emergency department may change observation strategy. | The revised Scandinavian Neurotrauma Committee (SNC) guidelines on management of patients with head trauma include an option for measurement of S100B in peripheral blood with 100% sensitivity for neurosurgical intervention. A medical technology assessment was conducted to evaluate any impact of using S100B on the use o... | 25,186,536 | [
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Almost half of women with malignant mesothelioma were exposed to asbestos at home through their husbands or sons. | Women often develop malignant mesothelioma (MM) without occupational asbestos exposure. Northern Jutland has a high prevalence of MM due to previously high occupational exposures to asbestos. The aim of this study was to elucidate a possible domestic exposure to asbestos through first-degree relatives in women who deve... | 25,186,542 | [
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Seckel syndrome with severe sinus bradycardia. | Seckel syndrome is an uncommon form of microcephalic dwarfism. The authors report a young boy with Seckel syndrome who presented with severe sinus bradycardia with symptoms of syncope and presyncope. Implantation of a permanent pacemaker was necessary in view of the severe symptoms. Although uncommon, cardiac abnormali... | 25,186,569 | [
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Therapeutic effects of the long-term use of PAN membrane dialyzer in hemodialysis patients: efficacy in old dialysis patients with mild PAD. | AN69 dialyzer, a plate type dialyzer with a polyacrylonitrile membrane (PAN membrane) is reported to reduce symptoms in hemodialysis (HD) patients with complications such as poor nutritional status and peripheral arterial disease (PAD). Yet very few studies have investigated the long-term use of the PAN membrane or com... | 25,186,576 | [
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Flexor pollicis longus rupture in a trigger thumb after intrasheath triamcinolone injections: a case report with literature review. | We report an unusual case of a rupture of the flexor pollicis longus tendon after two intrasheath triamcinolone injections for left trigger thumb in a 56-year-old woman. Tendon grafting from proximal to the wrist to the fingertip was carried out using the palmaris longus tendon. The clinical result was evaluated as goo... | 25,186,581 | [
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0.116... |
Peptides and peptidomimetics as immunomodulators. | Peptides and peptidomimetics can function as immunomodulating agents by either blocking the immune response or stimulating the immune response to generate tolerance. Knowledge of B- or T-cell epitopes along with conformational constraints is important in the design of peptide-based immunomodulating agents. Work on the ... | 25,186,605 | [
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Vedolizumab: an α4β7 integrin inhibitor for inflammatory bowel diseases. | To review the pharmacology, efficacy, and safety of vedolizumab in the treatment of patients with ulcerative colitis (UC) and Crohn's disease (CD). A literature search through clinicialtrials.gov, EMBASE and MEDLINE was conducted (January 1966-June 2014) using the terms vedolizumab and MLN0002. References from retrieve... | 25,186,623 | [
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Is there a right to access innovative surgery? | Demands for access to experimental therapies are frequently framed in the language of rights. This article examines the justifiability of such demands in the specific context of surgical innovations, these being promising but non-validated and potentially risky departures from standard surgical practices. I argue that ... | 25,186,629 | [
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Stable isotopic analysis of porcine, bovine, and ovine heparins. | The assessment of provenance of heparin is becoming a major concern for the pharmaceutical industry and its regulatory bodies. Batch-specific [carbon (δ(13) C), nitrogen (δ(15) N), oxygen (δ(18) O), sulfur (δ(34) S), and hydrogen (δD)] stable isotopic compositions of five different animal-derived heparins were performe... | 25,186,630 | [
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Inoculation of drought-stressed strawberry with a mixed inoculum of two arbuscular mycorrhizal fungi: effects on population dynamics of fungal species in roots and consequential plant tolerance to water deficiency. | The effect of inoculation with two arbuscular mycorrhizal fungi (AMF) on growth and drought tolerance of cultivated strawberry (Fragaria × ananassa) was studied. Three treatments (a single treatment either of Funneliformis mosseae BEG25, Funneliformis geosporus BEG11 or a 50:50 mixed inoculation treatment of both speci... | 25,186,649 | [
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A neuron model of stochastic resonance using rectangular pulse trains. | Stochastic resonance (SR) is the enhanced representation of a weak input signal by the addition of an optimal level of broadband noise to a nonlinear (threshold) system. Since its discovery in the 1980s the domain of input signals shown to be applicable to SR has greatly expanded, from strictly periodic inputs to now n... | 25,186,655 | [
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A public health and budget impact analysis of vaccinating the elderly and at-risk adults with the 23-valent pneumococcal polysaccharide vaccine or 13-valent pneumococcal conjugate vaccine in the UK. | Since the introduction of the routine childhood immunization, a change in epidemiology of pneumococcal disease has been seen in both children and adults. This study aimed to quantify the public health and budget impact of pneumococcal vaccination of the elderly and those in at risk groups in the UK. The model was adapt... | 25,186,657 | [
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0.3527058,
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Voltage-driven photoluminescence modulation of liquid-crystalline hybridized ZnO nanoparticles. | Liquid-crystalline hybrid nanomaterials have been obtained by grafting mesogenic units around luminescent ZnO nanocrystals of 5 nm in diameter. Modifying the mesogenic density around the inorganic core allows the modulation of the liquid-crystalline behavior and its miscibility in commercial liquid crystal (LC). The st... | 25,186,659 | [
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Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface. | The isolation of human monoclonal antibodies is providing important insights into the specificities that underlie broad neutralization of HIV-1 (reviewed in ref. 1). Here we report a broad and extremely potent HIV-specific monoclonal antibody, termed 35O22, which binds a novel HIV-1 envelope glycoprotein (Env) epitope.... | 25,186,731 | [
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An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. | The major cell classes of the brain differ in their developmental processes, metabolism, signaling, and function. To better understand the functions and interactions of the cell types that comprise these classes, we acutely purified representative populations of neurons, astrocytes, oligodendrocyte precursor cells, new... | 25,186,741 | [
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Form-cue invariant second-order neuronal responses to contrast modulation in primate area V2. | A fundamental task of the visual system is to extract figure-ground boundaries between images of objects, which in natural scenes are often defined not only by luminance differences but also by "second-order" contrast or texture differences. Responses to contrast modulation (CM) and other second-order stimuli have been... | 25,186,753 | [
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TDP-43 toxicity proceeds via calcium dysregulation and necrosis in aging Caenorhabditis elegans motor neurons. | Amyotrophic lateral sclerosis (ALS) is a heterogeneous disease with either sporadic or genetic origins characterized by the progressive degeneration of motor neurons. At the cellular level, ALS neurons show protein misfolding and aggregation phenotypes. Transactive response DNA-binding protein 43 (TDP-43) has recently ... | 25,186,754 | [
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Linking macroscale graph analytical organization to microscale neuroarchitectonics in the macaque connectome. | Macroscale connectivity of the mammalian brain has been shown to display several characteristics of an efficient communication network architecture. In parallel, at the microscopic scale, histological studies have extensively revealed large interregional variation in cortical neural architectonics. However, how these t... | 25,186,762 | [
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Dual nanoparticle amplified surface plasmon resonance detection of thrombin at subattomolar concentrations. | A novel dual nanoparticle amplification approach is introduced for the enhanced surface plasmon resonance (SPR) detection of a target protein at subattomolar concentrations. Thrombin was used as a model target protein as part of a sandwich assay involving an antithrombin (anti-Th) modified SPR chip surface and a thromb... | 25,186,782 | [
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Fluid shear stress stimulates osteogenic differentiation of human periodontal ligament cells via the extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase signaling pathways. | Fluid shear stress (FSS) is a major type of mechanical stress that is loaded on human periodontal ligament cells (hPDLCs) during mastication and orthodontic tooth movement. This study aims to clarify the effect of FSS on the osteogenic differentiation of hPDLCs and to further verify the involvement of mitogen-activated... | 25,186,781 | [
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"My YAP Family": Analysis of a Facebook Group for Young Adults Living with HIV. | Little research exists regarding the use of social networking sites, like Facebook, for improving patient well-being. The aim of this study was to evaluate a private Facebook group established for members of an HIV clinic's young adult program. This study employed directed content analysis to examine the types and freq... | 25,186,783 | [
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Disclosure of their status to youth with human immunodeficiency virus infection in the Dominican Republic: a mixed-methods study. | A mixed-methods study was conducted to determine the proportion of HIV-infected children who knew their status, identify characteristics associated with children's knowledge of their status, and describe caregivers' and adolescents' experiences relevant to disclosure in the Dominican Republic (DR). Of 327 patients aged... | 25,186,784 | [
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An autopsy case of Balamuthia mandrillaris amoebic encephalitis, a rare emerging infectious disease, with a brief review of the cases reported in Japan. | Balamuthia mandrillaris is an amoeba found in fresh water and soil that causes granulomatous amoebic encephalitis. We report herein an autopsy case of B. mandrillaris amoebic encephalitis, which was definitely diagnosed by PCR. An 81-year-old man, who had Sjögren's syndrome, manifested drowsiness 2 months before his de... | 25,186,798 | [
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Two-dimensional motility of a macrophage cell line on microcontact-printed fibronectin. | The ability of macrophages to migrate to sites of infection and inflammation is critical for their role in the innate immune response. Macrophage cell lines have made it possible to study the roles of individual proteins responsible for migration using molecular biology, but it has not been possible to reliably elicit ... | 25,186,818 | [
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Current techniques for pediatric liver transplantation. | Orthotopic liver transplantation in the pediatric population is a technically challenging undertaking, requiring highly specialized surgical techniques unique to this group. This review describes the most current method of transplantation for these patients. Pediatric liver transplantation employs multiple modification... | 25,186,822 | [
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Deltoid ligament repair versus syndesmotic fixation in bimalleolar equivalent ankle fractures. | To compare the outcomes of bimalleolar equivalent ankle fractures treated with lateral malleolus open reduction and internal fixation (ORIF) with transsyndesmotic fixation versus lateral malleolus ORIF with deltoid ligament repair. Retrospective design. Single level I trauma center. Subjects with bimalleolar equivalent... | 25,186,845 | [
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Vaccination strategies to improve outcome of hematopoietic stem cell transplant in leukemia patients: early evidence and future prospects. | Allogeneic hematopoietic stem cell transplantation (HSCT) has largely improved the prognosis of leukemia patients. However, relapse is still a major concern. One promising option for the prevention of relapse is vaccination therapy. The post allogeneic HSCT period provides a unique platform for vaccination, because tum... | 25,186,852 | [
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RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis. | Receptor interacting protein kinase 1 (RIPK1) has an essential role in the signalling triggered by death receptors and pattern recognition receptors. RIPK1 is believed to function as a node driving NF-κB-mediated cell survival and inflammation as well as caspase-8 (CASP8)-dependent apoptotic or RIPK3/MLKL-dependent nec... | 25,186,904 | [
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Development and application of aromatic [(13)C, (1)H] SOFAST-HMQC NMR experiment for nucleic acids. | Higher sensitivity of NMR spectrometers and novel isotopic labeling schemes have ushered the development of rapid data acquisition methodologies, improving the time resolution with which NMR data can be acquired. For nucleic acids, longitudinal relaxation optimization in conjunction with Ernst angle excitation (SOFAST-... | 25,186,910 | [
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Differences between rosuvastatin and atorvastatin in lipid-lowering action and effect on glucose metabolism in Japanese hypercholesterolemic patients with concurrent diabetes. Lipid-lowering with highly potent statins in hyperlipidemia with type 2 diabetes patients (LISTEN) study –. | Little is known about the differences between standard-dose statins effects on glucose level and lipids in Japanese patients with diabetes mellitus (DM). The 1,049 patients were randomly assigned to either the rosuvastatin group or atorvastatin group. There were no significant differences between the 2 groups in the ef... | 25,186,922 | [
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Effects of Visual Information on Wind-Evoked Escape Behavior of the Cricket, Gryllus bimaculatus. | We investigated the effects of visual information on wind-evoked escape behavior in the cricket, Gryllus bimaculatus. Most agitated crickets were found to retreat into a shelter made of cardboard installed in the test arena within a short time. As this behavior was thought to be a type of escape, we confirmed how a vis... | 25,186,926 | [
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Assembling multiporphyrin stacks inside the DNA double helix. | Double stranded DNA hybrids containing up to four consecutive, face-to-face stacked porphyrins are described. Non-nucleosidic, 5,15-bisphenyl-substituted porphyrin building blocks were incorporated into complementary oligonucleotide strands. Upon hybridization multiple porphyrins are well accommodated inside the DNA sc... | 25,186,936 | [
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... |
Induction of apoptosis in colon cancer cells treated with isorhamnetin glycosides from Opuntia ficus-indica pads. | (OFI) contains health-promoting compounds like flavonoids, being the isorhamnetin glycosides the most abundant. We evaluated the effect of OFI extracts with different isorhamnetin glycosides against two different human colon cancer cells (HT-29 and Caco2). The extracts were obtained by alkaline hydrolysis with NaOH at ... | 25,186,940 | [
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The genomic landscape of pediatric Ewing sarcoma. | Pediatric Ewing sarcoma is characterized by the expression of chimeric fusions of EWS and ETS family transcription factors, representing a paradigm for studying cancers driven by transcription factor rearrangements. In this study, we describe the somatic landscape of pediatric Ewing sarcoma. These tumors are among the ... | 25,186,949 | [
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Borna disease virus (BDV) infection in psychiatric patients and healthy controls in Iran. | Borna disease virus (BDV) is an evolutionary old RNA virus, which infects brain and blood cells of humans, their primate ancestors, and other mammals. Human infection has been correlated to mood disorders and schizophrenia, but the impact of BDV on mental-health still remains controversial due to poor methodological an... | 25,186,971 | [
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Use of facebook as a tool for knowledge dissemination in dermatology. | The presence of dermatology-related platforms in social media has been acknowledged; however, the level of engagement of the public with these platforms has not been evaluated. To use the Engagement Rate to assess the level of engagement of the public with Facebook pages devoted to dermatology. A search on Facebook ide... | 25,186,996 | [
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Successful treatment of calciphylaxis with intravenous sodium thiosulfate in a nonuremic patient: case report and review of therapy side effects. | AbstractBackground:Calciphylaxis is a life-threatening condition traditionally observed in patients with end-stage renal disease. Cases of nonuremic calciphylaxis have also been reported, but data on this rare condition are mainly empirical. To present a case of severe nonuremic calciphylaxis treated with intravenous s... | 25,186,999 | [
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Autonomic regulation therapy via left or right cervical vagus nerve stimulation in patients with chronic heart failure: results of the ANTHEM-HF trial. | ANTHEM-HF evaluated a novel autonomic regulation therapy (ART) via either left or right vagus nerve stimulation (VNS) in patients with heart failure (HF) and reduced ejection fraction (HFrEF). Sixty subjects (New York Heart Association [NYHA] functional class II-III, left ventricular ejection fraction (LVEF) ≤ 40%, lef... | 25,187,002 | [
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A first look at the Oxford Nanopore MinION sequencer. | Oxford Nanopore's third-generation single-molecule sequencing platform promises to decrease costs for reagents and instrumentation. After a 2-year hiatus following the initial announcement, the first devices have been released as part of an early access program. We explore the performance of this platform by resequenci... | 25,187,008 | [
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Perspectives of vulnerable U.S Hispanics with rheumatoid arthritis on depression: awareness, barriers to disclosure, and treatment options. | Despite the high prevalence of depression among vulnerable Hispanics with rheumatoid arthritis (RA), many do not disclose it or seek treatment. This study explored patient perceptions of depression, its association with their primary disease, barriers to disclosure, reasons for low utilization of mental health care res... | 25,187,020 | [
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... |
Real-time PCR carried out on DNA extracted from serum or blood sample is not a good method for surveillance of bovine brucellosis. | Bovine brucellosis is endemic in many parts of the world including India. The disease diagnosis and surveillance are usually carried out by serological tests, which however have drawbacks. This study was undertaken to evaluate the potential of real-time PCR (RT-PCR) targeting bcsp31 gene for surveillance of bovine bruc... | 25,187,027 | [
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Clone mapper: an online suite of tools for RNAi experiments in Caenorhabditis elegans. | RNA interference (RNAi), mediated by the introduction of a specific double-stranded RNA, is a powerful method to investigate gene function. It is widely used in the Caenorhabditis elegans research community. An expanding number of laboratories conduct genome-wide RNAi screens, using standard libraries of bacterial clon... | 25,187,039 | [
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