title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Acupuncture and relaxation response for craving and anxiety reduction among military veterans in recovery from substance use disorder. | Substance use disorder (SUD) is a major health issue, especially among military veterans. We previously reported the effects of auricular acupuncture and the relaxation response (RR) on reducing craving and anxiety following 10-week interventions among veterans who were in recovery from SUDs. Our current analysis exami... | 25,187,049 | [
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Posttraumatic stress symptoms and alcohol problems: self-medication or trait vulnerability? | Posttraumatic stress symptoms (PTSD) and problem alcohol use (ALC) commonly co-occur, but the nature of this co-occurrence is unclear. Self-medication explanations have been forwarded, yet traits such as tendency toward negative emotionality and behavioral disconstraint also have been implicated. In this study we test ... | 25,187,046 | [
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Silicon-core glass fibres as microwire radial-junction solar cells. | Vertically aligned radial-junction solar cell designs offer potential improvements over planar geometries, as carrier generation occurs close to the junction for all absorption depths, but most production methods still require a single crystal substrate. Here, we report on the fabrication of such solar cells from polyc... | 25,187,060 | [
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Expanding the indications for single-incision laparoscopic cholecystectomy to all patients with biliary disease: is it safe? | The safety of single-incision laparoscopic cholecystectomy (SILC) has been proven in well-selected patients. The objective of this study was to determine whether SILC can be offered to all patients with any indication for cholecystectomy. A total of 173 consecutive SILCs were performed between January 2010 and November... | 25,187,074 | [
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HIV is an independent predictor of aortic stiffness. | Patients with treated Human Immunodeficiency Virus-1 (HIV) infection are at increased risk of cardiovascular events. Traditionally much of this risk has been attributed to metabolic and anthropometric abnormalities associated with HIV, which are similar to the metabolic syndrome (MS), an established risk factor for car... | 25,187,084 | [
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Brugada electrocardiogram pattern "unmasked" by amiodarone infusion. | Brugada syndrome predisposes individuals to ventricular arrhythmias and sudden cardiac death, in the absence of structural heart disease. The typical Brugada electrocardiogram (ECG) phenotype is often concealed in affected population, and the existing genetic testing is capable of detecting just about 20% of cases. The... | 25,187,091 | [
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Canagliflozin-Associated Acute Pancreatitis. | Canagliflozin is a new drug in class of sodium-glucose cotransporter 2 inhibitors used for treatment of type 2 diabetes mellitus. We describe a patient who developed moderately severe acute pancreatitis as an untoward consequence after being initiated on this drug. To the best of our knowledge, this is the first report... | 25,187,092 | [
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Electrochemical, spectroscopic, and (1)O2 sensitization characteristics of 10,10-dimethylbiladiene complexes of zinc and copper. | The synthesis, electrochemistry, and photophysical characterization of a 10,10-dimethylbiladiene tetrapyrrole bearing ancillary pentafluorophenyl groups at the 5- and 15-meso positions (DMBil1) is presented. This nonmacrocyclic tetrapyrrole platform is robust and can serve as an excellent ligand scaffold for Zn(2+) and... | 25,187,099 | [
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Observational outcome results following a randomized controlled trial of early amino acid administration in preterm infants. | Several reports have investigated amino acid administration in premature infants during the early postnatal phase. Most of these previous studies, however, have only evaluated short-term in-hospital outcomes. Our aim was to describe long-term outcomes in premature infants previously subjected to different nutritional r... | 25,187,104 | [
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Choice of Health Options In prevention of Cardiovascular Events for people with Atrial Fibrillation (CHOICE-AF): A pilot study. | Atrial fibrillation (AF), the most common cardiac arrhythmia, is associated with high risk of stroke and significant health burden. Recent emerging evidence suggests that modifying risk factor profiles of people with AF may assist to reduce stroke risk and health burden. The purpose of this study was to test the feasib... | 25,187,121 | [
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ITS1: a DNA barcode better than ITS2 in eukaryotes? | A DNA barcode is a short piece of DNA sequence used for species determination and discovery. The internal transcribed spacer (ITS/ITS2) region has been proposed as the standard DNA barcode for fungi and seed plants and has been widely used in DNA barcoding analyses for other biological groups, for example algae, protis... | 25,187,125 | [
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Reuse of waste beer yeast sludge for biosorptive decolorization of reactive blue 49 from aqueous solution. | Reactive blue 49 was removed from aqueous solution by biosorption using powder waste sludge composed of Saccharomyces cerevisiae from the beer-brewing industry. The effect of initial pH, temperature and the biosorption thermodynamics, equilibrium, kinetics was investigated in this study. It was found that the biosorpti... | 25,187,128 | [
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Biodegradation of malachite green by strain Pseudomonas sp. K9 and cloning of the tmr2 gene associated with an ISPpu12. | A bacterial strain K9 capable of degrading malachite green was isolated from the sludge of the wastewater treatment system of a chemical plant. It was identified preliminarily as Pseudomonas sp. Strain K9 was also able to degrade other triphenylmethane dyes, such as Crystal Violet and Basic Fuchsin. The gene tmr2, enco... | 25,187,131 | [
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MutS-mediated enrichment of mutated DNA produced by directed evolution in vitro. | Directed evolution in vitro is a powerful tool in the study and design of protein function. However, screening the desired mutants is a difficult task. To facilitate the screening, a method is proposed to eliminate wild type sequences and increase mutated DNA sequences, which is based on the preferential binding of Mut... | 25,187,136 | [
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Thermoactive β-N-acetylhexosaminidase production by a soil isolate of Penicillium monoverticillium CFR 2 under solid state fermentation: parameter optimization and application for N-acetyl chitooligosaccharides preparation from chitin. | Two fungal strains were evaluated for β-N-acetylhexosaminidase production by solid state fermentation using different agro-industrial residues such as commercial wheat bran (CWB) and shrimp shell chitin waste (SSCW), of which Penicillium monoverticillium CFR 2 a local soil isolate showed significantly (P ≤ 0.001) highe... | 25,187,143 | [
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Heat and phosphate starvation effects on the proteome, morphology and chemical composition of the biomining bacteria Acidithiobacillus ferrooxidans. | Acidithiobacillus ferrooxidans is a Gram negative, acidophilic, chemolithoautotrophic bacterium that plays an important role in metal bioleaching. During bioleaching, the cells are subjected to changes in the growth temperature and nutrients starvation. The aim of this study was to gather information about the response... | 25,187,146 | [
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The impact of exposure model misspecification on signal detection in prospective pharmacovigilance. | Pharmacovigilance monitors the safety of drugs after their approval and marketing. Timely detection of adverse effects is important. The true relationship between time-varying drug use and the adverse event risk is typically unknown. Yet, most current pharmacovigilance studies rely on arbitrarily chosen exposure metric... | 25,187,155 | [
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Differences in immunogenicity of HLA antigens and the impact of cross-reactivity on the humoral response. | Information about differences in immunogenicity of various HLA antigens may help guide donor selection and identify mismatches to avoid for patients likely to need retransplantation. To date, antibody responses to a wide array of individual mismatched antigens have not been evaluated. Frequencies of antibodies to misma... | 25,187,165 | [
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Expression of ZAT12 transcripts in transgenic tomato under various abiotic stresses and modeling of ZAT12 protein in silico. | ZAT12 a C2H2-zinc-finger protein is an abiotic stress-responsive transcription factor in plants having less information about their structure. Transcription analysis proved that ZAT12 transcripts over-expressed during drought, heat and salt stress conditions which led to an interest in 3-D structural studies of ZAT12in... | 25,187,181 | [
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Sequential Bi-C bond activation reactions of BiEt₃ via insertion reactions of RE {R = HC[C(Me)N(2,6-i-Pr₂C₆H₃)]₂; E = Al, Ga, In}. | Two of the Bi-C bonds of BiEt3 are sequentially activated by mono-valent RM {R = HC[C(Me)N(2,6-i-Pr2C6H3)]2; M = Al, Ga, In}. The first Bi-C bond activation leads to the formation of insertion complexes, [RMEt(BiEt2)] (M = Al 1; Ga 2; In 3), whereas the consecutive second activation proceeds through a reductive elimina... | 25,187,200 | [
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Cellular damage suffered by equine embryos after exposure to cryoprotectants or cryopreservation by slow-freezing or vitrification. | Equine embryos are cryopreserved by slow-freezing or vitrification. While small embryos (<300 μm) survive cryopreservation reasonably well, larger embryos do not. It is not clear if slow-freezing or vitrification is less damaging to horse embryos. To compare the type and extent of cellular damage suffered by small a... | 25,187,202 | [
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Glucose transporter 1-positive endothelial cells in infantile hemangioma exhibit features of facultative stem cells. | Endothelial glucose transporter 1 (GLUT1) is a definitive and diagnostic marker for infantile hemangioma (IH), a vascular tumor of infancy. To date, GLUT1-positive endothelial cells in IH have not been quantified nor directly isolated and studied. We isolated GLUT1-positive and GLUT1-negative endothelial cells from IH ... | 25,187,207 | [
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A performance comparison of the paediatric i-gel with other supraglottic airway devices. | We performed a review of published literature comparing the i-gel with other supraglottic airway devices in children. Sixty-two articles were identified following a literature search; we included data from 14 randomised controlled trials and eight observational studies that compared i-gel sizes 1-2.5 with other commonl... | 25,187,212 | [
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Measuring extracellular pH in a lung fibrosis model with acidoCEST MRI. | A feed-forward loop involving lactic acid production may potentially occur during the formation of idiopathic pulmonary fibrosis. To provide evidence for this feed-forward loop, we used acidoCEST MRI to measure the extracellular pH (pHe), while also measuring percent uptake of the contrast agent, lesion size, and the a... | 25,187,227 | [
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'True' null allele detection in microsatellite loci: a comparison of methods, assessment of difficulties and survey of possible improvements. | Null alleles are alleles that for various reasons fail to amplify in a PCR assay. The presence of null alleles in microsatellite data is known to bias the genetic parameter estimates. Thus, efficient detection of null alleles is crucial, but the methods available for indirect null allele detection return inconsistent r... | 25,187,238 | [
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Oxidative stress and cannabinoid receptor expression in type-2 diabetic rat pancreas following treatment with Δ⁹-THC. | The objectives of study were (a) to determine alteration of feeding, glucose level and oxidative stress and (b) to investigate expression and localization of cannabinoid receptors in type-2 diabetic rat pancreas treated with Δ(9)-tetrahydrocannabinol (Δ(9)-THC). Rats were randomly divided into four groups: control, Δ(9... | 25,187,240 | [
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WS₂ 2D nanosheets in 3D nanoflowers. | In this work it has been established that 3D nanoflowers of WS2 synthesised by chemical vapour deposition are composed of few layer WS2 along the edges of the petals. An experimental study in order to understand the evolution of these nanostructures shows the nucleation and growth along with the compositional changes t... | 25,187,313 | [
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Ameliorative effects of docosahexaenoic acid on the toxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in cultured rat hepatocytes. | The 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is an environmental contaminant toxicant that mediates carcinogenic effects associated with oxidative DNA damage. Docosahexaenoic acid (DHA) with antioxidant functions has many biochemical, cellular, and physiological functions for cells. The present study assessed, for th... | 25,187,318 | [
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Mutagenicity of automobile workshop soil leachate and tobacco industry wastewater using the Ames Salmonella fluctuation and the SOS chromotests. | Environmental management of industrial solid wastes and wastewater is an important economic and environmental health problem globally. This study evaluated the mutagenic potential of automobile workshop soil-simulated leachate and tobacco wastewater using the SOS chromotest on Escherichia coli PQ37 and the Ames Salmone... | 25,187,319 | [
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The effect of radiofrequency turbinoplasty vs two other methods in the management of polypoid changes of the middle turbinate: a randomized trial. | The aim of this study was to evaluate the effectiveness of middle turbinate radiofrequency (RF) turbinoplasty for the management of the polypoid middle turbinate compared to middle turbinate resection and middle turbinate medialization. The study was performed on 90 patients at a tertiary referral hospital with nasal p... | 25,187,345 | [
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Temporal triangular alopecia: significance of trichoscopy in differential diagnosis. | There are only two case reports in literature regarding the trichoscopic features of temporal triangular alopecia (TTA). Differential diagnosis of other types of localized alopecia such as alopecia areata is necessary in some cases. To evaluate the potential benefit of trichoscopy in the clinical diagnosis of TTA. Nine... | 25,187,354 | [
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Skin advanced glycation end products glucosepane and methylglyoxal hydroimidazolone are independently associated with long-term microvascular complication progression of type 1 diabetes. | Six skin collagen advanced glycation end products (AGEs) originally measured near to the time of the Diabetes Control and Complications Trial (DCCT) closeout in 1993 may contribute to the "metabolic memory" phenomenon reported in the follow-up Epidemiology of Diabetes Interventions and Complications (EDIC) study. We ha... | 25,187,362 | [
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Assessment of β-cell mass and α- and β-cell survival and function by arginine stimulation in human autologous islet recipients. | We used intravenous arginine with measurements of insulin, C-peptide, and glucagon to examine β-cell and α-cell survival and function in a group of 10 chronic pancreatitis recipients 1-8 years after total pancreatectomy and autoislet transplantation. Insulin and C-peptide responses correlated robustly with the number o... | 25,187,365 | [
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Stress response protein cirp links inflammation and tumorigenesis in colitis-associated cancer. | Colitis-associated cancer (CAC) is caused by chronic intestinal inflammation and is reported to be associated with refractory inflammatory bowel disease (IBD). Defective apoptosis of inflammatory cell populations seems to be a relevant pathogenetic mechanism in refractory IBD. We assessed the involvement of stress resp... | 25,187,386 | [
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Surgical treatment of intrahepatic cholangiocarcinoma in the USA. | Cholangiocarcinoma (CC) is a malignancy that arises from the epithelial cells of the biliary system (ductules as well as large ducts, and likely from progenitor cells, as well). Intrahepatic CC (ICC) is the second most common primary hepatic malignancy after hepatocellular carcinoma (HCC), and accounts for 10-15% of pr... | 25,187,408 | [
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Arsenic trioxide and microRNA-204 display contrary effects on regulating adipogenic and osteogenic differentiation of mesenchymal stem cells in aplastic anemia. | Our previous studies have demonstrated that arsenic trioxide (ATO) had the clinical efficacy in treating patients with aplastic anemia (AA). However, the mechanisms remain to be elucidated. The important components of the bone marrow hematopoietic microenvironment, bone marrow mesenchymal stem cells (BMSCs), are often ... | 25,187,411 | [
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Rostafuroxin protects from podocyte injury and proteinuria induced by adducin genetic variants and ouabain. | Glomerulopathies are important causes of morbidity and mortality. Selective therapies that address the underlying mechanisms are still lacking. Recently, two mechanisms, mutant β-adducin and ouabain, have been found to be involved in glomerular podocytopathies and proteinuria through nephrin downregulation. The main pu... | 25,187,430 | [
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Pattern of underreporting falls in a general psychiatric hospital in Japan. | To examine the pattern of underreporting of fall incidents in a general psychiatric hospital in Japan. All fall incidents were analyzed and stratified by ward. A discrepancy in fall rates was found in acute psychiatric and dementia wards. The following indicators were suggestive of underreporting: "zero fall/1,000 pati... | 25,187,446 | [
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"Providing structure" as a psychiatric nursing intervention: a review of the literature. | The focus is on a nursing intervention called "providing structure" (PS). This label does not exist in the Nursing Interventions Classification. The following three questions were asked: (a) How is PS defined? (b) What are the goals of PS? and (c) What is the evidence regarding the effectiveness of PS? A systematic lit... | 25,187,449 | [
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Factors that influence the diagnoses of Asian Americans in mental health: an exploration. | This 10-year review of Asian Americans focuses on factors that impede adequate psychiatric diagnosis and treatment. Asian Americans are the fastest growing ethnic group in the United States, with a high prevalence of domestic violence, alcohol abuse, and significant distress. However, Asian Americans consistently under... | 25,187,450 | [
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Histological insights into the pathogenesis of post-Roux-en-Y hyperinsulinaemic hypoglycaemia. | β-cell hyperplasia has been implicated in the aetiology of post Roux-en-Y gastric bypass hyperinsulinaemic hypoglycaemia, but the pathogenesis of this condition is still unclear. We report a case of a 52-year-old man with post-Roux-en-Y gastric bypass hyperinsulinaemic hypoglycaemia who underwent distal pancreatectomy ... | 25,187,473 | [
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Image-based high-throughput field phenotyping of crop roots. | Current plant phenotyping technologies to characterize agriculturally relevant traits have been primarily developed for use in laboratory and/or greenhouse conditions. In the case of root architectural traits, this limits phenotyping efforts, largely, to young plants grown in specialized containers and growth media. He... | 25,187,526 | [
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Molecular characterization of a novel temperate sinorhizobium bacteriophage, ФLM21, encoding DNA methyltransferase with CcrM-like specificity. | ΦLM21 is a temperate phage isolated from Sinorhizobium sp. strain LM21 (Alphaproteobacteria). Genomic analysis and electron microscopy suggested that ΦLM21 is a member of the family Siphoviridae. The phage has an isometric head and a long noncontractile tail. The genome of ΦLM21 has 50,827 bp of linear double-stranded ... | 25,187,538 | [
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A histidine residue of the influenza virus hemagglutinin controls the pH dependence of the conformational change mediating membrane fusion. | The conformational change of the influenza virus hemagglutinin (HA) protein mediating the fusion between the virus envelope and the endosomal membrane was hypothesized to be induced by protonation of specific histidine residues since their pKas match the pHs of late endosomes (pK(a) of ∼ 6.0). However, such critical ke... | 25,187,542 | [
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Characterization of simian immunodeficiency virus (SIV) that induces SIV encephalitis in rhesus macaques with high frequency: role of TRIM5 and major histocompatibility complex genotypes and early entry to the brain. | Although nonhuman primate models of neuro-AIDS have made tremendous contributions to our understanding of disease progression in the central nervous system (CNS) of human immunodeficiency virus type 1 (HIV-1)-infected individuals, each model holds advantages and limitations. In this study, in vivo passage of SIVsmE543 ... | 25,187,546 | [
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Remodeling of a delivery complex allows ClpS-mediated degradation of N-degron substrates. | The ClpS adaptor collaborates with the AAA+ ClpAP protease to recognize and degrade N-degron substrates. ClpS binds the substrate N-degron and assembles into a high-affinity ClpS-substrate-ClpA complex, but how the N-degron is transferred from ClpS to the axial pore of the AAA+ ClpA unfoldase to initiate degradation is... | 25,187,555 | [
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Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET. | Dysregulation of the von Hippel-Lindau/hypoxia-inducible transcription factor (HIF) signaling pathway promotes clear cell renal cell carcinoma (ccRCC) progression and metastasis. The protein kinase GAS6/AXL signaling pathway has recently been implicated as an essential mediator of metastasis and receptor tyrosine kinas... | 25,187,556 | [
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Voltage-sensitive dye imaging of transcranial magnetic stimulation-induced intracortical dynamics. | Transcranial magnetic stimulation (TMS) is widely used in clinical interventions and basic neuroscience. Additionally, it has become a powerful tool to drive plastic changes in neuronal networks. However, highly resolved recordings of the immediate TMS effects have remained scarce, because existing recording techniques... | 25,187,557 | [
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High CO2 concentration increases relative leaf carbon gain under dynamic light in Dipterocarpus sublamellatus seedlings in a tropical rain forest, Malaysia. | Understory plants in tropical forests often experience a low-light environment combined with high CO2 concentration. We hypothesized that the high CO2 concentration may compensate for leaf carbon loss caused by the low light, through increasing light-use efficiency of both steady-state and dynamic photosynthetic proper... | 25,187,569 | [
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Comparison of ultrasound and electrodiagnostic testing for diagnosis of carpal tunnel syndrome: study using a validated clinical tool as the reference standard. | Ultrasound examination is both accurate and cost-effective for the confirmation of a clinical diagnosis of carpal tunnel syndrome. Previous studies have shown electrodiagnostic testing and ultrasound to be similar with regard to sensitivity and specificity. The purpose of this study was to compare the sensitivity and s... | 25,187,592 | [
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Assessment of moral reasoning skills in the orthopaedic surgery resident applicant. | Assessing orthopaedic surgery residency applicants is a complex process. One important applicant characteristic not commonly measured during the interview process is moral behavior, a key component of the guidelines of the Accreditation Council for Graduate Medical Education for professionalism competency. We sought to... | 25,187,595 | [
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Transgenerational impaired male fertility with an Igf2 epigenetic defect in the rat are induced by the endocrine disruptor p,p'-DDE. | What are the epigenetic mechanisms underlying the transgenerational effect of p,p'-DDE on male fertility? Impaired male fertility with an Igf2 epigenetic defect is transgenerationally inherited upon exposure of p,p'-DDE. p,p'-Dichlorodiphenoxydichloroethylene (p,p'-DDE) is one of the primary metabolite products of the ... | 25,187,598 | [
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Combination of contrast-enhanced wall motion analysis and myocardial deformation imaging during dobutamine stress echocardiography. | The combination of deformation analysis with conventional wall motion scoring (WMS) has been shown to increase the diagnostic sensitivity of dobutamine stress echocardiography (DSE). The feasibility and diagnostic power of WMS is largely improved by contrast agents; however, they are not used in combination with deform... | 25,187,604 | [
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Canine blastomycosis in Wisconsin: a survey of small-animal veterinary practices. | The disease burden and impact of canine blastomycosis in Wisconsin is uncertain. We surveyed small-animal veterinary practices to obtain estimates of disease incidence, determine patient outcomes, and investigate variation in diagnostic and treatment strategies used by veterinarians. Veterinarians representing small-an... | 25,187,628 | [
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Hepatitis E virus of subtype 3i in chronically infected kidney transplant recipients in southeastern France. | Hepatitis E virus (HEV) is a leading cause of waterborne acute hepatitis in developing countries. In Europe, HEV causes a zoonotic disease and is hyperendemic in southern France. Four HEV genotypes (1 to 4) have been defined, and the most used classification divides them into 24 subtypes. Autochthonous European HEV str... | 25,187,634 | [
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Characterization and multicentric validation of a common standard for Toxoplasma gondii detection using nucleic acid amplification assays. | The molecular diagnosis of toxoplasmosis essentially relies upon laboratory-developed methods and suffers from lack of standardization, hence the large diversity of performances between laboratories. Moreover, quantifications of parasitic loads differ among centers, a fact which prevents the possible prediction of the ... | 25,187,637 | [
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The HLA profiles of mixed connective tissue disease differ distinctly from the profiles of clinically related connective tissue diseases. | The Norwegian nationwide MCTD cohort was established to obtain unbiased data on key disease issues, and thereby reappraise the concept of MCTD. In the current study, the aims were to obtain detailed HLA profile data on the large Norwegian MCTD cohort and compare these with the HLA profiles of ethnically matched healthy... | 25,187,641 | [
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Impact on short-term glycaemic control of initiating diabetes care versus leaving diabetes untreated among individuals with newly screening-detected diabetes in Japan. | The impact of early initiation of diabetes care soon after the identification of hyperglycaemia rather than leaving diabetes untreated on changes in glycaemic control has not been fully clarified. We aimed to quantify the effect of initiating and continuing diabetes care compared with not starting management of diabete... | 25,187,645 | [
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Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin. | A long-standing issue in the field of signal transduction is to understand the cross-talk between receptor tyrosine kinases (RTKs) and heterotrimeric G proteins, two major and distinct signaling hubs that control eukaryotic cell behavior. Although stimulation of many RTKs leads to activation of trimeric G proteins, the... | 25,187,647 | [
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Short-term n-3 fatty acid supplementation but not aspirin increases plasma proresolving mediators of inflammation. | Resolution of inflammation is an active process involving specialized proresolving mediators (SPM) formed from the n-3 fatty acids. This study examined the effect of n-3 fatty acid supplementation and aspirin on plasma SPMs in healthy humans. Healthy volunteers (n = 21) were supplemented with n-3 fatty acids (2.4g/day)... | 25,187,667 | [
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From early markers to neuro-developmental mechanisms of autism. | A fast growing field, the study of infants at risk because of having an older sibling with autism (i.e. infant sibs) aims to identify the earliest signs of this disorder, which would allow for earlier diagnosis and intervention. More importantly, we argue, these studies offer the opportunity to validate existing neuro-... | 25,187,673 | [
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An open-label, one-year, noncomparative study to evaluate the safety and tolerability of intravitreal pegaptanib sodium in patients with diabetic macular edema. | The purpose of this study was to evaluate the safety and tolerability of pegaptanib in patients with diabetic macular edema. An open-label, multicenter, noncomparative, one-year study of approximately 500 patients was planned. Recruitment was terminated after enrollment of 46 patients. Enrolled patients were fully info... | 25,187,694 | [
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High infiltration of tumor-associated macrophages in triple-negative breast cancer is associated with a higher risk of distant metastasis. | Triple-negative breast cancer (TNBC) is associated with poor prognosis and high probability of distant metastases. Tumor microenvironments play a pivotal role in tumor metastasis. Tumor-associated macrophages (TAMs) are one of the main cell components, and they are correlated with increasing metastatic risk. The aim of... | 25,187,727 | [
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B-type (brain) natriuretic peptide and pruritus in hemodialysis patients. | While pruritus is a common complication in hemodialysis patients, the pathophysiological mechanisms remain obscure. Recently, B-type (brain) natriuretic peptide (BNP) has been defined as an itch-selective neuropeptide in pruriceptive neurons in mice, and higher serum levels of BNP are frequently observed in hemodialysi... | 25,187,733 | [
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A successful case of dose reduction in etizolam dependence using fine granules: a case report. | The prevalence of benzodiazepine consumption in Japan is one of the highest worldwide. Etizolam is the most abused drug of the benzodiazepine class. The treatment of benzodiazepine dependence is difficult. We report a case of successful dosage reduction in a 24-year-old female patient with etizolam dependence. She was ... | 25,187,742 | [
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Aborted sudden cardiac death and a mother with suspected metabolic myopathy. | Aborted sudden cardiac death (SCD) has not been reported as initial manifestation of cardiac involvement in metabolic myopathy (MM). A 20-year-old female with a previous history of three syncopes, hyperhidrosis, and recurrent tick bites experienced aborted SCD. Her mother presented with MM, and a history of pituitary a... | 25,187,745 | [
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Effect of vitamin d3 on untreated graves' disease with vitamin d deficiency. | Besides its classical role in calcium and bone homeostasis, vitamin D is considered a potent immunomodulator that can affect the pathogenesis of several autoimmune diseases. Our aim is to evaluate the effect of vitamin D correction to a patient with new onset Graves' disease (GD) with an underlying vitamin D deficiency... | 25,187,748 | [
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Beyond the time window of intravenous thrombolysis: standing by or by stenting? | Intravenous administration of tissue plasminogen activator within 4.5 h of symptom onset is presently the 'golden rule' for treating acute ischemic stroke. However, many patients miss the time window and others reject this treatment due to a long list of contraindications. Mechanical embolectomy has recently progressed... | 25,187,761 | [
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Carotid plaque hemodynamics. | Internal carotid artery (ICA) plaques constitute one major source of retinal and cerebral brain embolism. Current guidelines recommend optimal treatment of cardiovascular risk factors and recanalization based on the degree of ICA stenosis. However, ICA plaque composition, motion, vascularization, and local hemodynamics... | 25,187,766 | [
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Ischemia-reperfusion injury in stroke. | Despite ongoing advances in stroke imaging and treatment, ischemic and hemorrhagic stroke continue to debilitate patients with devastating outcomes at both the personal and societal levels. While the ultimate goal of therapy in ischemic stroke is geared towards restoration of blood flow, even when mitigation of initial... | 25,187,778 | [
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Sanmiao formula inhibits chondrocyte apoptosis and cartilage matrix degradation in a rat model of osteoarthritis. | Sanmiao formula (SM) is a basic prescription for the treatment of gouty and rheumatoid arthritis that has been used in China over a long period of history. However, there is no evidence associating SM with the treatment of osteoarthritis (OA). In this study, a characterization of the anti-OA effect of SM was conducted ... | 25,187,798 | [
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Combination therapy with low molecular weight heparin and Adriamycin results in decreased breast cancer cell metastasis in C<sub>3</sub>H mice. | The aim of this study was to investigate the effect of low molecular weight heparin (LMWH) against breast cancer cell invasion and metastasis in C<sub3</subH mice and the underlying mechanism. The C<sub3</subH mouse breast cancer model was established, and the mice were then randomly divided into four groups: normal sa... | 25,187,827 | [
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Pre-ischemic exercise alleviates oxidative damage following ischemic stroke in rats. | Physical exercise has been proved to be neuroprotective in clinical trials and animal experiments. However, the exact mechanism underlying this neuroprotective effect remains unclear. The aim of the present study was to explore whether pre-ischemic treadmill training could act as a form of ischemic preconditioning in a... | 25,187,848 | [
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Association of adiponectin protein and ADIPOQ gene variants with lumbar disc degeneration. | Lumbar disc degeneration (LDD) is a widespread public health problem that may lead to disability and loss of productivity. Adiponectin is an adipokine secreted by adipose tissue and has been shown to be involved in cartilage homeostasis. In the present study, the association between the rs266729 (-11377C/G) and rs22417... | 25,187,851 | [
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Lumbar morphometry: a study of lumbar vertebrae from a pakistani population using computed tomography scans. | A cross-sectional study. To describe the characteristics of lumbar vertebrae of Pakistani patients reporting at a tertiary care hospital and compare with studies from other populations. Several studies have been conducted to determine morphometry of lumbar vertebrae. Most of the studies involve Caucasian populations, s... | 25,187,858 | [
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An extremely giant lumbar schwannoma: new classification (kotil) and mini-open microsurgical resection. | Purely extradural giant lumbar schwannomas are rare lesions. Classification of these tumors is performed according to the sizes and spills and is named the modified Sridhar's classification. The management of these tumors has traditionally been performed by combined antero-posterior large or two-stage exposures. This c... | 25,187,870 | [
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Accuracy of clinical tests in the diagnosis of anterior cruciate ligament injury: a systematic review. | Numerous clinical tests are used in the diagnosis of anterior cruciate ligament (ACL) injury but their accuracy is unclear. The purpose of this study is to evaluate the diagnostic accuracy of clinical tests for the diagnosis of ACL injury. Systematic review. The review protocol was registered through PROSPERO (CRD4201... | 25,187,877 | [
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The 24-h FEV1 time profile of olodaterol once daily via Respimat® and formoterol twice daily via Aerolizer® in patients with GOLD 2-4 COPD: results from two 6-week crossover studies. | These studies evaluated the 24-h forced expiratory volume in 1 sec (FEV1) profile of once-daily (QD) olodaterol compared to placebo and twice-daily (BID) formoterol in patients with moderate to very severe chronic obstructive pulmonary disease. In two replicate, randomized, double-blind, double-dummy, four-way crossove... | 25,187,881 | [
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Profile of ocular trauma in the Solomon Islands. | The objective of this study was to characterize the causes of ocular trauma and determine the risk factors for infection and vision loss following ocular trauma in the Solomon Islands. A prospective clinic-based study. A total of 507 patients with ocular trauma who were reviewed at the National Referral Hospital in Hon... | 25,187,927 | [
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Noninvasive assessment of endothelial function and vascular parameters in patients with familial and nonfamilial hypercholesterolemia. | Endothelial dysfunction is one of the markers of atherosclerosis. The aim of the study was to evaluate endothelial function by assessing flow-mediated dilation (FMD) and to measure the parameters of brachial arterial stiffness in patients with familial hypercholesterolemia (FH) and those with high low-density lipoprote... | 25,187,945 | [
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Na+K+-ATPase activity and K+ channels differently contribute to vascular relaxation in male and female rats. | Gender associated differences in vascular reactivity regulation might contribute to the low incidence of cardiovascular disease in women. Cardiovascular protection is suggested to depend on female sex hormones' effects on endothelial function and vascular tone regulation. We tested the hypothesis that potassium (K+) ch... | 25,187,951 | [
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Brain-targeted delivery of trans-activating transcriptor-conjugated magnetic PLGA/lipid nanoparticles. | Magnetic poly (D,L-lactide-co-glycolide) (PLGA)/lipid nanoparticles (MPLs) were fabricated from PLGA, L-α-phosphatidylethanolamine (DOPE), 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-amino (polyethylene glycol) (DSPE-PEG-NH2), and magnetic nanoparticles (NPs), and then conjugated to trans-activating transcriptor ... | 25,187,980 | [
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0.2329498,
0.2108578,
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0.1659983,
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0.4431344,
0.03403283,
0.4431342,
0.08187273,
-0.1973057,
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0.005966907,
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0.04323099,
-0.2999403,
0.3867337,
0.1428625,
0.009722739,
-0.0153512... |
An siRNA screen of membrane trafficking genes highlights pathways common to HIV-1 and M-PMV virus assembly and release. | The assembly and release of retroviruses from the host cells requires a coordinated series of interactions between viral structural proteins and cellular trafficking pathways. Although a number of cellular factors involved in retrovirus assembly have been identified, it is likely that retroviruses utilize additional tr... | 25,187,981 | [
-0.09738375,
0.1096192,
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0.08870374,
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0.2897754,
0.1680263,
-0.06276198... |
Polarization holograms in a bifunctional amorphous polymer exhibiting equal values of photoinduced linear and circular birefringences. | Light-controlled molecular alignment is a flexible and useful strategy introducing novelty in the fields of mechanics, self-organized structuring, mass transport, optics, and photonics and addressing the development of smart optical devices. Azobenzene-containing polymers are well-known photocontrollable materials with... | 25,187,982 | [
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0.1720546,
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-0.259... |
Genetic diversity of Salmonella pathogenicity islands SPI-5 and SPI-6 in Salmonella Newport. | Salmonella enterica subspecies enterica serotype Newport is one of the common serotypes causing foodborne salmonellosis outbreaks in the United States. Salmonella Newport consists of three lineages exhibiting extensive genetic diversity. Due to the importance of Salmonella pathogenicity islands 5 and 6 (SPI-5 and SPI-6... | 25,188,010 | [
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0.04787104,
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0.2766656,
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Innovative care model for patients with complex muscle diseases. | Many neuromuscular disorders require complex multisystem management. This is especially true for the rapidly growing numbers of young adults surviving congenital and childhood onset conditions following improved multidisciplinary care and the routine use of home ventilation. Surveys from the United Kingdom and Netherla... | 25,188,015 | [
-0.1069682,
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0.1072932,
-0.032... |
Co-molten solvothermal method for synthesizing chalcopyrite CuFe(1-x)Cr(x)S₂ (x ≤ 0.4): high photocatalytic activity for the reduction of nitrate ions. | In literature, it is very difficult to obtain sulfides with Cr(3+) in tetrahedral coordination. Here, a thiourea-oxalic acid co-molten solvothermal method was applied to synthesize chalcopyrite CuFe(1-x)Cr(x)S2 (x ≤ 0.4) solid solutions. We propose that oxalic acid plays an important role in the crystallization of CuFe... | 25,188,017 | [
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-... |
Interdependency of subsurface carbon distribution and graphene-catalyst interaction. | The dynamics of the graphene-catalyst interaction during chemical vapor deposition are investigated using in situ, time- and depth-resolved X-ray photoelectron spectroscopy, and complementary grand canonical Monte Carlo simulations coupled to a tight-binding model. We thereby reveal the interdependency of the distribut... | 25,188,018 | [
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0.05510471,
0.3499007,
0.1121843,
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Causes of death among adults in northern Ethiopia: evidence from verbal autopsy data in health and demographic surveillance system. | In countries where registration of vital events is lacking and the proportion of people who die at home without medical care is high, verbal autopsy is used to determine and estimate causes of death. We conducted 723 verbal autopsy interviews of adult (15 years of age and above) deaths from September 2009 to January 20... | 25,188,025 | [
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0.3311764,
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... |
"New drug" designations for new therapeutic entities: new active substance, new chemical entity, new biological entity, new molecular entity. | This Perspective addresses ambiguities in designations of "new drugs" intended as new therapeutic entities (NTEs). Designation of an NTE as a new drug is significant, as it may confer regulatory exclusivity, an important incentive for development of novel compounds. Such designations differ between jurisdictions accord... | 25,188,028 | [
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0.2440798,
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0.07959594,
0.1388986,
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... |
American Thyroid Association statement on preoperative imaging for thyroid cancer surgery. | The success of surgery for thyroid cancer hinges on thorough and accurate preoperative imaging, which enables complete clearance of the primary tumor and affected lymph node compartments. This working group was charged by the Surgical Affairs Committee of the American Thyroid Association to examine the available litera... | 25,188,202 | [
-0.05211531,
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0.06951754,
0.1811352,
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0.0921455,
0.134927,
-0.4186995,
... |
The interaction between aggrecan gene VNTR polymorphism and obesity in predicting incident symptomatic lumbar disc herniation. | An association between aggrecan gene variable number of tandem repeats polymorphism (VNTR) and symptomatic lumbar disc herniation (LDH) has been reported in Chinese Han of Northern China, and obesity had previously been suspected of causing severe LDH. However, the interaction between aggrecan VNTR and obesity in sympt... | 25,188,217 | [
0.03822401,
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0.3314737,
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0.2499347,
0.2367221,
0.07636553,
-0.09195889,
0.3147596,
-0.1352111,
0.1971... |
Phase transitions in the multi-cellular regulatory behavior of pancreatic islet excitability. | The pancreatic islets of Langerhans are multicellular micro-organs integral to maintaining glucose homeostasis through secretion of the hormone insulin. β-cells within the islet exist as a highly coupled electrical network which coordinates electrical activity and insulin release at high glucose, but leads to global su... | 25,188,228 | [
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0.1892627,
0.2916104,
0.0116465,
0.3186047,
0.2061989,
0.1476813,
-0.... |
A predictive model combining fecal calgranulin B and fecal occult blood tests can improve the diagnosis of colorectal cancer. | Current fecal screening tools for colorectal cancer (CRC), such as fecal occult blood tests (FOBT), are limited by their low sensitivity. Calgranulin B (CALB) was previously reported as a candidate fecal marker for CRC. This study investigated whether a combination of the FOBT and fecal CALB has increased sensitivity a... | 25,188,229 | [
-0.2022916,
0.01968891,
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0.161507,
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0.1442455,
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-0.2000545,
0.4467274,
-0.3255346,
... |
Evolution of the F0F1 ATP synthase complex in light of the patchy distribution of different bioenergetic pathways across prokaryotes. | Bacteria and archaea are characterized by an amazing metabolic diversity, which allows them to persist in diverse and often extreme habitats. Apart from oxygenic photosynthesis and oxidative phosphorylation, well-studied processes from chloroplasts and mitochondria of plants and animals, prokaryotes utilize various che... | 25,188,293 | [
-0.2266347,
0.1111977,
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0.2534851,
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0.2287069,
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0.1034398,
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-0.08445584,
0.00002402406,
0.1309008,
0.4887731,
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Direct costs of dengue hospitalization in Brazil: public and private health care systems and use of WHO guidelines. | Dengue, an arboviral disease, is a public health problem in tropical and subtropical regions worldwide. In Brazil, epidemics have become increasingly important, with increases in the number of hospitalizations and the costs associated with the disease. This study aimed to describe the direct costs of hospitalized dengu... | 25,188,295 | [
-0.269688,
0.1282385,
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0.5468695,
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0.01636076,
0.02944057,
-0.1750892,
0... |
48-week efficacy and safety of dolutegravir relative to commonly used third agents in treatment-naive HIV-1-infected patients: a systematic review and network meta-analysis. | A network meta-analysis can provide estimates of relative efficacy for treatments not directly studied in head-to-head randomized controlled trials. We estimated the relative efficacy and safety of dolutegravir (DTG) versus third agents currently recommended by guidelines, including ritonavir-boosted atazanavir (ATV/r)... | 25,188,312 | [
0.01760824,
0.3865801,
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0.129358,
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0.06662398,
0.1376241,
0.2776391,
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0.4431703,
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0.1122964,
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0.349746,
-0.2502794,
0.5001398,
-0.2044578,
-0.08... |
Application of optimal designs to item calibration. | In computerized adaptive testing (CAT), examinees are presented with various sets of items chosen from a precalibrated item pool. Consequently, the attrition speed of the items is extremely fast, and replenishing the item pool is essential. Therefore, item calibration has become a crucial concern in maintaining item ba... | 25,188,318 | [
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0.1681678,
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0.1960412,
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0.409388,
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0.1102928,
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0.02987573,
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Is the link from working memory to analogy causal? No analogy improvements following working memory training gains. | Analogical reasoning has been hypothesized to critically depend upon working memory through correlational data, but less work has tested this relationship through experimental manipulation. An opportunity for examining the connection between working memory and analogical reasoning has emerged from the growing, although... | 25,188,356 | [
-0.2782936,
0.203624,
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0.2519351,
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0.0208907,
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0.2957187,
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0.07867667,
-0.176869... |
Salinity and bacterial diversity: to what extent does the concentration of salt affect the bacterial community in a saline soil? | In this study, the evaluation of soil characteristics was coupled with a pyrosequencing analysis of the V2-V3 16S rRNA gene region in order to investigate the bacterial community structure and diversity in the A horizon of a natural saline soil located in Sicily (Italy). The main aim of the research was to assess the o... | 25,188,357 | [
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0.3444815,
0.1689813,
0.01847772,
0.02805219,
0.1649156,
0.04295... |
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