title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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A semi-dominant mutation in the general splicing factor SF3a66 causes anterior-posterior axis reversal in one-cell stage C. elegans embryos. | Establishment of anterior-posterior polarity in one-cell stage Caenorhabditis elegans embryos depends in part on astral microtubules. As the zygote enters mitosis, these microtubules promote the establishment of a posterior pole by binding to and protecting a cytoplasmic pool of the posterior polarity protein PAR-2 fro... | 25,188,372 | [
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Emergence of assortative mixing between clusters of cultured neurons. | The analysis of the activity of neuronal cultures is considered to be a good proxy of the functional connectivity of in vivo neuronal tissues. Thus, the functional complex network inferred from activity patterns is a promising way to unravel the interplay between structure and functionality of neuronal systems. Here, w... | 25,188,377 | [
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When is spillover from marine reserves likely to benefit fisheries? | The net movement of individuals from marine reserves (also known as no-take marine protected areas) to the remaining fishing grounds is known as spillover and is frequently used to promote reserves to fishers on the grounds that it will benefit fisheries. Here we consider how mismanaged a fishery must be before spillov... | 25,188,380 | [
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Characterization of a spontaneous retinal neovascular mouse model. | Vision loss due to vascular disease of the retina is a leading cause of blindness in the world. Retinal angiomatous proliferation (RAP) is a subgroup of neovascular age-related macular degeneration (AMD), whereby abnormal blood vessels develop in the retina leading to debilitating vision loss and eventual blindness. Th... | 25,188,381 | [
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Combined use of systemic agents for psoriasis: a systematic review. | Combined use of systemic agents may be necessary to achieve disease control in therapy-resistant patients. However, to our knowledge, an overview of evidence, including quality assessments, is not yet available, and no guidance on monitoring, contraindications, and interactions exists. To summarize and critically appra... | 25,188,393 | [
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Tissue-specific RNA expression marks distant-acting developmental enhancers. | Short non-coding transcripts can be transcribed from distant-acting transcriptional enhancer loci, but the prevalence of such enhancer RNAs (eRNAs) within the transcriptome, and the association of eRNA expression with tissue-specific enhancer activity in vivo remain poorly understood. Here, we investigated the expressi... | 25,188,404 | [
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The prognostic value of serum neuron-specific enolase in traumatic brain injury: systematic review and meta-analysis. | Several studies have suggested that neuron-specific enolase (NSE) in serum may be a biomarker of traumatic brain injury. However, whether serum NSE levels correlate with outcomes remains unclear. The purpose of this review was to evaluate the prognostic value of serum NSE protein after traumatic brain injury. PubMed an... | 25,188,406 | [
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Role of the DNA base excision repair protein, APE1 in cisplatin, oxaliplatin, or carboplatin induced sensory neuropathy. | Although chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting side effect of platinum drugs, the mechanisms of this toxicity remain unknown. Previous work in our laboratory suggests that cisplatin-induced CIPN is secondary to DNA damage which is susceptible to base excision repair (BER). To further exam... | 25,188,410 | [
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Revealing molecular mechanisms by integrating high-dimensional functional screens with protein interaction data. | Functional genomics screens using multi-parametric assays are powerful approaches for identifying genes involved in particular cellular processes. However, they suffer from problems like noise, and often provide little insight into molecular mechanisms. A bottleneck for addressing these issues is the lack of computatio... | 25,188,415 | [
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The relation between resting state connectivity and creativity in adolescents before and after training. | An important component of creativity is divergent thinking, which involves the ability to generate novel and useful problem solutions. In this study, we tested the relation between resting-state functional connectivity of brain areas activated during a divergent thinking task (i.e., supramarginal gyrus, middle temporal... | 25,188,416 | [
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Noise-induced hearing loss: an occupational medicine perspective. | Up to 30 million workers in the United States are exposed to potentially detrimental levels of noise. Although reliable medications for minimizing or reversing noise-induced hearing loss (NIHL) are not currently available, NIHL is entirely preventable. The purpose of this article is to review the epidemiology and patho... | 25,188,429 | [
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Natural history, presentation, and diagnosis of hidradenitis suppurativa. | The diagnosis of hidradenitis suppurativa (HS) is based on a characteristic history and physical exam. The anatomic sites of involvement include the axillae (most common), groin, and buttocks, and the perianal, perineal, and mammary regions. Initially, HS manifests with open comedones (usually with two or more "heads")... | 25,188,458 | [
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Improved adverse postoperative outcomes with revised American College of Cardiology/American Heart Association guidelines for patients with cardiac stents. | In 2007, the American College of Cardiology/American Heart Association guidelines were revised for patients with cardiac stents in need of subsequent surgery to recommend delaying elective noncardiac surgery by 365 days in patients with drug-eluting stents (DESs). To examine the effect of the guidelines on postoperativ... | 25,188,466 | [
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Treatment-related adverse events in patients with relapsed/refractory multiple myeloma. | In the past decade we have seen four new agents approved by the US Food and Drug Administration for treatment of multiple myeloma: the proteasome inhibitor (PI) bortezomib (Velcade), the immunomodulatory agents lenalidomide (Revlimid) and thalidomide (Thalomid), and liposomal doxorubicin. These are commonly used in the... | 25,188,481 | [
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Validity and reliability assessment of detailed scoring checklists for use during perioperative emergency simulation training. | Few valid and reliable grading checklists have been published for the evaluation of performance during simulated high-stakes perioperative event management. As such, the purposes of this study were to construct valid scoring checklists for a variety of perioperative emergencies and to determine the reliability of score... | 25,188,486 | [
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MYCN repression of Lifeguard/FAIM2 enhances neuroblastoma aggressiveness. | Neuroblastoma (NBL) is the most common solid tumor in infants and accounts for 15% of all pediatric cancer deaths. Several risk factors predict NBL outcome: age at the time of diagnosis, stage, chromosome alterations and MYCN (V-Myc Avian Myelocytomatosis Viral Oncogene Neuroblastoma-Derived Homolog) amplification, whi... | 25,188,511 | [
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Correction: AKT Inhibitors Promote Cell Death in Cervical Cancer through Disruption of mTOR Signaling and Glucose Uptake. | [This corrects the article DOI: 10.1371/journal.pone.0092948.]. | 25,188,521 | [
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Challenges in defining and categorizing falls on diverse unit types: lessons from expansion of the NDNQI Falls Indicator. | In 2012, the National Database of Nursing Quality Indicators launched a project to expand its falls indicator for use on pediatric, neonatal, and psychiatric units. We discuss challenges encountered, argue that schemes for categorizing falls by cause or supposed preventability are not suitable for large-scale efforts t... | 25,188,525 | [
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Ophthalmic patients' utilization of technology and social media: an assessment to improve quality of care. | E-health tools have the potential to improve the quality of care for ophthalmic patients, many of whom have chronic conditions. However, little research has assessed ophthalmic patients' use or acceptance of technological devices and social media platforms for health-related purposes. The present study evaluated utiliz... | 25,188,532 | [
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Role of fat and adipokines in intestinal inflammation. | This review summarizes current knowledge on the contribution of mesenteric adipose tissue in intestinal inflammation. We will describe the cellular and humoral characteristics of creeping fat, their potential impact for Crohn's disease and propose a working model for the critical interplay between the creeping fat and ... | 25,188,546 | [
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Emerging medical informatics research trends detection based on MeSH terms. | The aim of this study is to analyze the research trends of medical informatics over the last 12 years. A new method based on MeSH terms was proposed to identify emerging topics and trends of medical informatics research. Informetric methods and visualization technologies were applied to investigate research trends of m... | 25,188,551 | [
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Therapeutic effect of dynamic interpersonal group psychotherapy for taiwanese patients with depressive disorder. | This study investigated the therapeutic effects of dynamic interpersonal group psychotherapy (DIGP) for the depressed in Taiwan. A 16-session DIGP was held weekly, and participants were evaluated with the Hamilton Depression Rating Scale, Taiwanese Depression Questionnaire, and World Health Organization Quality of Life... | 25,188,566 | [
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RNA graph partitioning for the discovery of RNA modularity: a novel application of graph partition algorithm to biology. | Graph representations have been widely used to analyze and design various economic, social, military, political, and biological networks. In systems biology, networks of cells and organs are useful for understanding disease and medical treatments and, in structural biology, structures of molecules can be described, inc... | 25,188,578 | [
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Preoperative anemia does not predict complications after single-level lumbar fusion: a propensity score-matched multicenter study. | Multicenter retrospective cohort study. To estimate the impact of preoperative anemia on 30-day complications in patients undergoing single-level lumbar fusion. Anemia has been widely implicated as a risk factor in various surgical procedures including elective spine surgery. No large-scale study has been performed to ... | 25,188,593 | [
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Simulation of the progression of intervertebral disc degeneration due to decreased nutritional supply. | Simulate the progression of human disc degeneration. The objective of this study was to quantitatively analyze and simulate the changes in cell density, nutritional level, proteoglycan (PG) content, water content, and volume during human disc degeneration using a numerical method. Understanding the cause and progressio... | 25,188,596 | [
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The 5-year cost-effectiveness of anterior cervical discectomy and fusion and cervical disc replacement: a Markov analysis. | A Markov state-transition model was developed to evaluate the cost-effectiveness of anterior cervical discectomy and fusion (ACDF) and cervical disc replacement (CDR) at 5 years. To determine the cost-effectiveness of ACDF and CDR at 5 years. ACDF and CDR are surgical options for the treatment of an acute cervical disc... | 25,188,602 | [
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Copper-mediated intramolecular oxidative C-H/N-H cross-coupling of α-alkenoyl ketene N,S-acetals to synthesize pyrrolone derivatives. | CuCl2 and CuBr2-mediated intramolecular oxidative C-H/N-H cross-coupling/halogenation of β-thioalkyl-substituted α-alkenoyl ketene N,S-acetals occurred efficiently, affording 4-halo-5-thioalkyl-3-pyrrolones. Tunable C-S and C-halo bond transformations of the resultant pyrrolone derivatives led to highly functionalized ... | 25,188,605 | [
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Synergistic antitumor effect of α-pinene and β-pinene with paclitaxel against non-small-cell lung carcinoma (NSCLC). | The objective of the present research work was to evaluate the synergistic interactions between Paclitaxel (PAC) with α-pinene and β-pinene using isobolographic method against non-small-cell lung cancer cells (NSCLC). This type of interaction between an established drug and a new compound is expected to enhance the eff... | 25,188,609 | [
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... |
Incidence and hospitalisation rates of Lyme borreliosis, France, 2004 to 2012. | Lyme borreliosis (LB) has become a major concern recently, as trends in several epidemiological studies indicate that there has been an increase in this disease in Europe and America over the last decade. This work provides estimates of LB incidence and hospitalisation rates in France. LB data was obtained from the Sen... | 25,188,613 | [
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Effectiveness of seasonal trivalent inactivated influenza vaccine in preventing influenza hospitalisations and primary care visits in Auckland, New Zealand, in 2013. | This study reports the first vaccine effectiveness (VE) estimates for the prevention of general practice visits and hospitalisations for laboratory-confirmed influenza from an urban population in Auckland, New Zealand, in the same influenza season (2013). A case test-negative design was used to estimate propensity-adju... | 25,188,614 | [
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Depression, somatic symptoms, and perceived neighborhood environments among US-born and non-US-born free clinic patients. | The study's purpose was to examine the impact of somatic symptoms and perceived neighborhood environment on depression using a comparison among US-born and non-US-born free clinic patients. US-born English speakers (n = 99), non-US-born English speakers (n = 89), and non-US-born Spanish speakers (n = 158) 18 years old ... | 25,188,626 | [
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Tips for a physician in getting the right job, part XVI: Assessing the relationship between the group and the hospital(s). | For those job seekers seeking a position with a group of physicians, it is critical to assess the relationship of the hospital administration to the group, and also to physicians generally. Ideally, the relationship should be one of partnership, with mutual cooperation and seeking to understand and help each other. A h... | 25,188,642 | [
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Alcohol intake and risk of injury. | Injuries constitute a leading cause of morbidity and mortality in the world, with intentional injuries and those related to traffic most important, due to their social impact and high prevalence. Although alcohol consumption has been identified as a risk factor for injuries, few studies have assessed risk separately fo... | 25,188,654 | [
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[Treatment of pulmonary vein stenosis secondary to radiofrequency ablation]. | Isolation of the pulmonary veins by applying radiofrequency is an effective treatment for atrial fibrillation. One of the potential complications with higher clinical compromise utilizing this invasive technique is the occurrence of stenosis of one or more pulmonary veins. This complication can be treated by angioplast... | 25,188,658 | [
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[Nevoid basal cell carcinoma syndrome with corpus callosum agenesis, PTCH1 mutation and absence of basal cell carcinoma]. | Nevoid Basal Cell Carcinoma Syndrome (NBCCS) or Gorlin-Goltz syndrome is a rare autosomal dominant disorder, mainly due to PTCH1 gene mutations, that comprises a broad spectrum of clinical manifestations. The presence of multiple basal cell carcinomas (BCCs) is a cardinal sign in NBCCS, therefore cases in which BCCs ar... | 25,188,659 | [
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Dual glutathione-S-transferase-θ1 and -μ1 gene deletions determine imatinib failure in chronic myeloid leukemia. | Approximately 40% of patients with chronic myeloid leukemia (CML) receiving imatinib fail treatment. There is an increased risk of CML in subjects with (i) deletions of genes encoding glutathione-S-transferase (GST)-θ1 (GSTT1) and -μ1, (GSTM1) and (ii) the GST-π1 (GSTP1) single-nucleotide polymorphism (SNP) Ile105Val (... | 25,188,725 | [
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Enhanced Raman and luminescence spectra from co-encapsulated silicon quantum dots and Au-Ag nanoalloys. | We report an approach to enhance simultaneously luminescence and SERS signals with a single excitation wavelength by co-encapsulating silicon quantum dots and Au-Ag alloy nanoparticles encoded with Raman reporter molecules inside polymeric nanoparticles. The SERS-luminescence enhancement exploits the large Stokes shift... | 25,188,727 | [
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Postnatal development and LPS responsiveness of pulmonary adenosine receptor expression and of adenosine-metabolizing enzymes in mice. | Adenosine levels are regulated by ecto-5'-nucleotidase/CD73 and adenosine deaminase (ADA). Adenosine regulates endothelial permeability and anti-inflammatory responses via adenosine receptors. Here, the adenosine receptors and purine-converting enzymes were studied during postnatal development and inflammation. Newborn... | 25,188,742 | [
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Conceptualizing the impact of special events on community health service levels: an operational analysis. | Mass gatherings (MG) impact their host and surrounding communities and with inadequate planning, may impair baseline emergency health services. Mass gatherings do not occur in a vacuum; they have both consumptive and disruptive effects that extend beyond the event itself. Mass gatherings occur in real geographic locati... | 25,188,753 | [
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Distinguishable Zn(II) and Pb(II) template effects on forming pendant-armed Schiff-base macrocyclic complexes including a remarkable Pb(II)-π macrocyclic complex. | 36-Membered [2 + 2] half-fold Schiff-base macrocyclic dinuclear Zn(II) complexes (1a and 1b) and 18-membered [1 + 1] Schiff-base macrocyclic mononuclear Pb(II) complexes (2 and 3) are produced from the condensation between 1,3-propanediamine and a pair of extended dialdehydes with different functional pendant arms (H2h... | 25,188,754 | [
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Reliability and validity of the Turkish form of the eight-item Morisky medication adherence scale in hypertensive patients. | The aim of this study is to evaluate the reliability and validity of the Turkish version of the 8-item Morisky medication adherence scale. The study was conducted as a methodological design. The study included 196 patients with hypertension who applied to the Family Health Centers in three different regions of Turkey. ... | 25,188,758 | [
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Mid-term assessment of cardiac autonomic functions in children with transposition of the great arteries after arterial switch operation. | It has been documented that impaired heart rate variability (HRV) is related to life threatening arrhythmias in children with surgically repaired congenital heart disease. We aimed to analyze the balance of the cardiac autonomic functions by assessing HRV in children with arterial switch operation (ASO). In this observ... | 25,188,763 | [
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Ceramic ware waste as coarse aggregate for structural concrete production. | The manufacture of any kind of product inevitably entails the production of waste. The quantity of waste generated by the ceramic industry, a very important sector in Spain, is between 5% and 8% of the final output and it is therefore necessary to find an effective waste recovery method. The aim of the study reported i... | 25,188,783 | [
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Tacrolimus for the treatment of subepithelial infiltrates resistant to topical steroids after adenoviral keratoconjunctivitis. | To describe the use of topical 0.03% tacrolimus in patients with symptomatic corneal subepithelial infiltrates (SEIs) secondary to adenoviral keratoconjunctivitis (AK) that were resistant to tapering of corticosteroid eye drops. This was a prospective, nonrandomized, noncomparative interventional case series that inclu... | 25,188,789 | [
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N-heterocyclic carbene-promoted annulation reaction of allenals with chalcones: synthesis of polysubstituted pyranyl aldehydes. | A general N-heterocyclic carbene (NHC)-promoted annulation reaction of allenals with chalcones affording polysubstituted pyranyl aldehydes has been developed. Three mechanistic possible pathways have been proposed. The NHC attacks the center carbon of allenals or acts as a base for deprotonation and then undergoes a 1,... | 25,188,791 | [
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Stimuli-responsive conformational conversion of peptide gatekeepers for controlled release of guests from mesoporous silica nanocontainers. | The use of peptides as gatekeepers for payloads of mesoporous silica nanoparticles would allow triggering the release of guests by various biological stimuli. We investigated the effect of peptide conformation on their gatekeeping capability by employing two model peptides with a turn or a random structure. The conform... | 25,188,823 | [
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Isolation and characterization of Vibrio cholerae isolates from seafood in Hat Yai City, Songkhla, Thailand. | Seafood has been identified as an important source of Vibrio cholerae in Thailand, especially in the Southern coastal region. In this study, we isolated and characterized V. cholerae from seafood obtained from several markets in Hat Yai city, Southern Thailand. A total of 100 V. cholerae isolates were obtained from 55 ... | 25,188,839 | [
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Engineering bacterial transcription regulation to create a synthetic in vitro two-hybrid system for protein interaction assays. | Transcriptional activation of σ(54)-RNA polymerase holoenzyme (σ(54)-RNAP) in bacteria is dependent on a cis-acting DNA element (bacterial enhancer), which recruits the bacterial enhancer-binding protein to contact the holoenzyme via DNA looping. Using a constructive synthetic biology approach, we recapitulated such pr... | 25,188,838 | [
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Corrosivity of paper mill effluent and corrosion performance of stainless steel. | Present study relates to the corrosivity of paper mill effluent and corrosion performance of stainless steel (SS) as a construction material for the effluent treatment plant (ETP). Accordingly, immersion test and electrochemical polarization tests were performed on SS 304 L, 316 L and duplex 2205 in paper mill effluent... | 25,188,842 | [
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HBV and HIV coinfections among intending blood donors in Port Harcourt, Nigeria. | HBV is a major public health concern as it afflicts an estimated 350 million people worldwide. Studies are crucial and necessary to give us a better understanding of the epidemiology of the diseases in developing countries. A clearer picture of HBV/HIV prevalence in Africa is important in order to better educate the po... | 25,188,859 | [
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BRAF mutation is associated with a specific cell type with features suggestive of senescence in ovarian serous borderline (atypical proliferative) tumors. | Serous borderline tumor also known as atypical proliferative serous tumor (APST) is the precursor of ovarian low-grade serous carcinoma (LGSC). In this study, we correlated the morphologic and immunohistochemical phenotypes of 71 APSTs and 18 LGSCs with the mutational status of KRAS and BRAF, the most common molecular ... | 25,188,864 | [
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Facilitating the Cope rearrangement by partial protonation: implications for synthesis and biosynthesis. | The theoretical investigation of concerted and stepwise Cope rearrangements of natural products led to the prediction that some concerted Cope rearrangements can be promoted by noncovalent association of their transition state structures with ammonium cations. | 25,188,876 | [
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Use of imiquimod for residual acral melanoma. | Recent reports suggest that topical imiquimod cream is an effective treatment option for certain types of melanomas. No reports exist on the efficacy of using imiquimod cream to treat melanoma located on the plantar surface of the foot. We present two patients with a melanoma of the foot who had residual melanoma follo... | 25,188,932 | [
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Multiple territory watershed infarcts following spinal anaesthesia. | Hypotension is one of the most common complications of spinal anaesthesia (SA). The intraoperative drop in the blood pressure is clearly associated with increased morbidity and mortality. In order to increase the awareness of this complication, we report a case of devastating stroke following an SA in a previously well... | 25,188,933 | [
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Getting the priorities right in end-of-life care. | The Leadership Alliance for the Care of Dying People has drawn up five priorities for the care of dying people. The priorities replace the Liverpool Care Pathway, which was widely criticised for promoting a tick-box approach to the care of the dying. The five priorities focus on: recognising that someone is dying; comm... | 25,188,966 | [
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["Purified empiricism": Johann Christian Reil's (1759-1813) attempts at a foundation of medicine in relation to its tradition, kantianism, and speculative philosophy]. | Johann Christian Reil's (1759-1813) importance lies in his theoretical approach to medicine. Following Kant in his early work, he attempts to combine medical experience with an underlying conceptual structure. This attempt is directed against both the chaotic empiricism of traditional medicine and speculative theories ... | 25,188,999 | [
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[Who should undergo atrial fibrillation ablation?]. | Atrial fibrillation is the most common sustained arrhythmia and its prevalence increases significantly with age. This editorial discusses the review by Laish-Farkash et al. regarding ablation of atrial fibrillation, especially in the elderly, as well as new ablation modalities. | 25,189,029 | [
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[Education and training system in child and adolescent psychiatry with view to carry-over towards adulthood psychiatry]. | The aim of our study was to develop and establish a training system in child and adolescent psychiatry in Japan, especially in light of the continuity and integration with general psychiatry. The Japanese authors surveyed the situation of training in child and adolescent psychiatry (CAP training) through the literature... | 25,189,043 | [
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[The role of psychiatrists in cooperative activity with school staff in school mental health]. | Although it was started some ten years ago in Japan that psychiatrists should be involved as specialists in mental health activity in schools, what was expected at most was to give some therapeutic suggestions on inquiry by teachers in relation to desirable solutions to reduce problem behaviors as pathological symptoms... | 25,189,048 | [
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Land use effects on leaf litter breakdown in low-order streams draining a rapidly developing tropical watershed in Puerto Rico. | Land use has an important role influencing stream ecosystem processes, such as leaf litter breakdown. Here, we assessed rates of leaf litter breakdown in low-order tropical streams draining forest, agriculture, and urban land uses in Puerto Rico. To measure leaf breakdown rates, we placed litter bags made of coarse mes... | 25,189,074 | [
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Cost-effectiveness of vaccinating the elderly and at-risk adults with the 23-valent pneumococcal polysaccharide vaccine or 13-valent pneumococcal conjugate vaccine in the UK. | The introduction of routine childhood vaccination with pneumococcal conjugate vaccines (PCVs) has led to a decrease in the overall incidence of pneumococcal disease in all ages and a change in the serotype distribution of the remaining disease. This study assessed the cost-effectiveness of vaccinating ≥65 years and at ... | 25,189,087 | [
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Fibroblast phenotypes in different lung diseases. | The "seed and soil" hypothesis emphasizes the importance of interactions between tumor cells and their microenvironment. CAFs (Cancer associated fibroblasts) are important components of the tumor microenvironment. They were widely involved in cancer cells growth and metastasis. Fibroblasts may also play a role in infla... | 25,189,096 | [
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Duhuo Jisheng Decoction‑containing serum promotes proliferation of interleukin‑1β‑induced chondrocytes through the p16‑cyclin D1/CDK4‑Rb pathway. | Duhuo Jisheng Decoction (DHJSD) is a traditional Chinese herbal medicine that has multiple uses, including as a treatment for osteoarthritis (OA). However, the molecular mechanisms underlying the therapeutic effects of DHJSD on OA remain unknown. In the present study, a serum pharmacological method was applied to inves... | 25,189,115 | [
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Constituents of Vigna angularis and their in vitro anti-inflammatory activity. | Nine non-phenolic compounds, including four furanylmethyl glycosides, angularides A-D, one ent-kaurane diterpene glycoside, angularin A, and four triterpenoid saponins, angulasaponins A-D, were isolated from seeds of Vigna angularis, together with eight known compounds. Their structures were elucidated on the basis of ... | 25,189,119 | [
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Isolation of α-glucosidase inhibitors including a new flavonol glycoside from Dendrobium devonianum. | From the whole plant of Dendrobium devonianum, a new flavonol glycoside, 5-hydroxy-3-methoxy-flavone-7-O-[β-D-apiosyl-(1 → 6)]-β-D-glucoside, as well as 13 known compounds, was isolated. Their structures were identified based on extensive spectroscopic studies including HR-EI-MS, (1)H, (13)C NMR, DEPT, H-H COSY, HSQC, ... | 25,189,122 | [
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Enhancing protein-vitamin binding residues prediction by multiple heterogeneous subspace SVMs ensemble. | Vitamins are typical ligands that play critical roles in various metabolic processes. The accurate identification of the vitamin-binding residues solely based on a protein sequence is of significant importance for the functional annotation of proteins, especially in the post-genomic era, when large volumes of protein s... | 25,189,131 | [
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The journey to psychosis: an exploration of specific psychological pathways. | Recent models of psychosis have implicated specific psychological processes in the aetiology of this disorder, and these factors may form a route to later symptoms-either directly or via a mediating pathway after exposure to adversity. Researchers are beginning to bring together findings that look into specific pathway... | 25,189,139 | [
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Validity and Reliability Analysis of the 'SayangKU' (MyLove) in Intervention for Addressing Adolescents Involved in Free Sex. | A module entitled 'SayangKU' (MyLove), based on the Islamic perspective, was developed as an instrument to assist adolescents that involved in premarital sexual activity. The module comprises four phases: Love of God (Allah), Love of the Prophet, Love of Oneself, and Love of the Ummah (world). From analysis of Rasch, t... | 25,189,148 | [
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Strategy for development of clinically useful glyco-biomarkers. | Recent advancements in proteomics technology have stimulated the widespread research and development in the area of biomarker discovery using mass spectrometry (MS). The final goal of biomarker discovery and development is to establish clinically useful and reliable diagnostic methods for various diseases. Specific alt... | 25,189,155 | [
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A transient increase in eosinophils is associated with prolonged survival in men with metastatic castration-resistant prostate cancer who receive sipuleucel-T. | Sipuleucel-T is an autologous cellular immunotherapy used to treat asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC). Traditional short-term indicators of clinical response commonly used with chemotherapy have not correlated with survival in patients treated with sipuleucel-T... | 25,189,164 | [
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Early resuscitation of dengue shock syndrome in children with hyperosmolar sodium-lactate: a randomized single-blind clinical trial of efficacy and safety. | Dengue shock syndrome (DSS) fluid resuscitation by following the World Health Organization (WHO) guideline usually required large volumes of Ringer lactate (RL) that might induce secondary fluid overload. Our objective was to compare the effectiveness of the recommended volume of RL versus a smaller volume of a hyperto... | 25,189,175 | [
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Capturing needles in haystacks: a comparison of B-cell receptor sequencing methods. | Deep-sequencing methods are rapidly developing in the field of B-cell receptor (BCR) and T-cell receptor (TCR) diversity. These promise to revolutionise our understanding of adaptive immune dynamics, identify novel antibodies, and allow monitoring of minimal residual disease. However, different methods for BCR and TCR ... | 25,189,176 | [
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The relapsing fever spirochete Borrelia miyamotoi is cultivable in a modified Kelly-Pettenkofer medium, and is resistant to human complement. | Borrelia miyamotoi is a relapsing fever spirochete found in Ixodes ticks in North America, Europe, and Asia, and has recently been found to be invasive in humans. Cultivation of this spirochete has not yet been described, but is important for patient diagnostics and scientific purposes. Host specificity of Borrelia spe... | 25,189,195 | [
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A genome-wide association analysis for porcine serum lipid traits reveals the existence of age-specific genetic determinants. | The genetic determinism of blood lipid concentrations, the main risk factor for atherosclerosis, is practically unknown in species other than human and mouse. Even in model organisms, little is known about how the genetic determinants of lipid traits are modulated by age-specific factors. To gain new insights into this... | 25,189,197 | [
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Large-scale generation of cell-derived nanovesicles. | Exosomes are enclosed compartments that are released from cells and that can transport biological contents for the purpose of intercellular communications. Research into exosomes is hindered by their rarity. In this article, we introduce a device that uses centrifugal force and a filter with micro-sized pores to genera... | 25,189,198 | [
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Is prophylactic psychiatry around the corner? combating adolescent oxidative stress for adult psychosis and schizophrenia. | Early detection and intervention are key principles in clinical medicine and psychiatry. In this issue of Neuron, Cabungcal et al. (2014) demonstrate that prophylactic treatment with antioxidants in adolescence prevents adult deficits in a rat model relevant to schizophrenia. | 25,189,204 | [
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Same-Sex Domestic Violence: Prevalence, Unique Aspects, and Clinical Implications. | Domestic violence is a significant public health issue. Prevalence rates for same-sex domestic violence vary because of methodological issues related to recruitment and definitions of sexual orientation. However, such prevalence rates are currently considered to be similar to slightly greater than other-sex prevalence ... | 25,189,218 | [
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Procalcitonin guidance for reduction of antibiotic use in patients hospitalized with severe acute exacerbations of asthma: a randomized controlled study with 12-month follow-up. | Patients with severe acute exacerbations of asthma often receive inappropriate antibiotic treatment. We aimed to determine whether serum procalcitonin (PCT) levels can effectively and safely reduce antibiotic exposure in patients experiencing exacerbations of asthma. In this randomized controlled trial, a total of 216 ... | 25,189,222 | [
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Detection of parent-of-origin effects for quantitative traits using general pedigree data. | Genomic imprinting is a genetic phenomenon in which certain alleles are differentially expressed in a parent-of-origin-specific manner, and plays an important role in the study of complex traits. For a diallelic marker locus in human, the parentalasymmetry tests Q-PAT(c) with any constant c were developed to detect par... | 25,189,228 | [
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Patterns of microsatellite evolution inferred from the Helianthus annuus (Asteraceae) transcriptome. | The distribution of microsatellites in exons, and their association with gene ontology (GO) terms is explored to elucidate patterns of microsatellite evolution in the common sunflower, Helianthus annuus. The relative position, motif, size and level of impurity were estimated for each microsatellite in the unigene datab... | 25,189,238 | [
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High-risk human papillomavirus in Galicia, Spain: prevalence and evaluation of the sample representativeness. | The prevalence of high-risk genotypes of the human papillomavirus (HR-HPV) in Galicia remained unknown before the introduction of the HPV vaccine. The objective of this study was to estimate this prevalence in non-vaccinated women when vaccination against HR-HPV started. Sample representativeness was also evaluated. Fe... | 25,189,272 | [
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Stressful life events and the perpetration of adolescent dating abuse. | Theoretical and empirical evidence suggests that stressful life events are associated with the perpetration of intimate partner violence among adults, but little attention has been given to the relationship between stressful life events and adolescent dating abuse, a prevalent form of violence that results in serious a... | 25,189,287 | [
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Optical detection of CO and CO2 temperature dependent desorption from carbon nanotube clusters. | The development of new materials relies on high precision methods to quantify adsorption/desorption of gases from surfaces. One commonly used approach is temperature programmed desorption spectroscopy. While this approach is very accurate, it requires complex instrumentation, and it is limited to performing experiments... | 25,189,292 | [
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0.1749397,
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0.1488155,
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... |
Academy of Medicine-Ministry of Health clinical practice guidelines: attention deficit hyperactivity disorder. | The Academy of Medicine (AMS) and the Ministry of Health (MOH) have developed the clinical practice guidelines on Attention Deficit Hyperactivity Disorder (ADHD) to provide doctors and patients in Singapore with evidence-based treatment for ADHD. This article reproduces the introduction and executive summary (with reco... | 25,189,301 | [
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Attitudes and perceptions of the general Malaysian public regarding family presence during resuscitation. | Family presence (FP) during resuscitation is an increasingly favoured trend, as it affords many benefits to the critically ill patient's family members. However, a previously conducted study showed that only 15.8% of surveyed Malaysian healthcare staff supported FP during resuscitation. This cross-sectional study used ... | 25,189,307 | [
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The Absent Interpreter in Administrative Detention Center Medical Units. | The particular situation of the French administrative detention center (ADC) medical units appears to be an exemplary case to study the difficulties facing medical practice. Indeed, the starting point of our inquiry was an amazing observation that needed to be addressed and understood: why are professional interpreters... | 25,189,317 | [
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Bilateral Achilles Tendon Ruptures Associated With Ciprofloxacin Use in the Setting of Minimal Change Disease: Case Report and Review of the Literature. | Fluoroquinolones are widely used antibiotics; however, numerous side effects have been reported in published studies, including a spectrum of tendinopathies, affecting numerous anatomic sites. Several risk factors have been identified, including advanced age (>60 years), corticosteroid use, renal failure or dialysis... | 25,189,336 | [
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Loss of keratinocytic RXRα combined with activated CDK4 or oncogenic NRAS generates UVB-induced melanomas via loss of p53 and PTEN in the tumor microenvironment. | Understanding the molecular mechanisms behind formation of melanoma, the deadliest form of skin cancer, is crucial for improved diagnosis and treatment. One key is to better understand the cross-talk between epidermal keratinocytes and pigment-producing melanocytes. Here, using a bigenic mouse model system combining mu... | 25,189,354 | [
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Computer-aided detection of exophytic renal lesions on non-contrast CT images. | Renal lesions are important extracolonic findings on computed tomographic colonography (CTC). They are difficult to detect on non-contrast CTC images due to low image contrast with surrounding objects. In this paper, we developed a novel computer-aided diagnosis system to detect a subset of renal lesions, exophytic les... | 25,189,363 | [
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0.214... |
Tanshinol protects human umbilical vein endothelial cells against hydrogen peroxide‑induced apoptosis. | The present study was designed to investigate the effect of tanshinol on hydrogen peroxide (H2O2)‑induced apoptosis in human umbilical vein endothelial cells (HUVECs), and to determine the underlying mechanisms. HUVECs were pre‑incubated with tanshinol (25‑200 µM) for 24 h, followed by an incubation with 600 µM H2O2 fo... | 25,189,379 | [
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0.163... |
Comparative secretome analysis of cholangiocarcinoma cell line in three-dimensional culture. | Cholangiocarcinoma (CCA) is a lethal malignancy which occurs with relatively high incidence in Thailand. This cancer is often difficult to diagnose and associated with high mortality. The secretome, containing the secreted proteins from cells, are potentially useful as biomarkers of cancers. Since three-dimensional (3D... | 25,189,380 | [
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Dual effect of interferon (IFNγ)-induced nitric oxide on tumorigenesis and intracellular bacteria. | Nitric oxide (NO) is a key messenger involved in numerous physiological functions including inflammatory and immune responses. The functions of NO and their underlying mechanisms have been elucidated by extensive studies over the past 10 years. However, the complexity of the interactions between different levels of NO ... | 25,189,392 | [
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Antiobesogenic role of endothelial nitric oxide synthase. | The prevalence of obesity has increased remarkably in the past four decades. Because obesity can promote the development of type 2 diabetes and cardiovascular disease, understanding the mechanisms that engender weight gain and discovering safe antiobesity therapies are of critical importance. In particular, the gaseous... | 25,189,393 | [
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Characterization of β-glucosidase produced by the white rot fungus Flammulina velutipes. | β-Glucosidase production by the white rot fungus Flammulina velutipes CFK 3111 was evaluated using different carbon and nitrogen sources under submerged fermentation. Maximal extracellular enzyme production was 1.6 U/ml, corresponding to a culture grown in sucrose 40 g/l and asparagine 10 g/l. High production yield was... | 25,189,408 | [
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Phylogenetic diversity of dominant bacterial and archaeal communities in plant-microbial fuel cells using rice plants. | In this study, the phylogenetic diversities of bacterial and archaeal communities in a plantmicrobial fuel cell (P-MFC) were investigated together with the environmental parameters, affecting its performance by using rice as a model plant. The beneficial effect of the plant appeared only during a certain period of the ... | 25,189,409 | [
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Simultaneous adsorption of SO2 and NO from flue gas over mesoporous alumina. | Mesoporous alumina (MA) with a higher ability to simultaneously remove SO2 and NO was prepared by the evaporation-induced self-assembly process. The adsorption capacities of MA are 1.79 and 0.702 mmol/g for SO2 and NO, respectively. The Brunauer-Emmett-Teller method was used to characterize the adsorbent. Simultaneous ... | 25,189,414 | [
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Preparation of multi-shelled conductive polymer hollow microspheres by using Fe₃O₄ hollow spheres as sacrificial templates. | Multi-shelled conductive polymer hollow microspheres were successfully generated by using Fe3O4 hollow microspheres as sacrificial templates via a programmed reaction-temperature process. Moreover, the multi-shelled PEDOT microspheres exhibited superb microwave absorption performance. | 25,189,419 | [
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Electrocatalytic activity of Pt subnano/nanoclusters stabilized by pristine graphene nanosheets. | Downsizing the Pt particle to the atomic level in the electro-catalysts is highly desirable to enhance its utilization efficiency in fuel cells. In this study, Pt subnano/nanoclusters were stabilized by the pristine graphene nanosheets (GNSs) derived from chemical vapor deposition and the resulting Pt/GNS hybrids were ... | 25,189,421 | [
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0.1634153,
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Menstrual pain and epithelial ovarian cancer risk. | Menstrual pain is associated with increased production of inflammatory molecules, such as prostaglandins. Inflammation is involved in pathogenesis of several cancers, including ovarian cancer. In this study, we examined the association between menstrual pain and risk of ovarian cancer. We conducted a case-control study... | 25,189,423 | [
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Microvascular dysfunction in the context of diabetic neuropathy. | Microvascular dysfunction in diabetes plays a crucial role in the development of diabetic complications. The skin, as one of the most accessible organs, serves as a model for the investigation of microvascular dysfunction. Several non-invasive, mostly laser-Doppler-based methods have been developed lately to assess mic... | 25,189,434 | [
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0.1992824,
0.06677... |
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