title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Surgical needs of Nepal: pilot study of population based survey in Pokhara, Nepal. | The Surgeons OverSeas assessment of surgical need (SOSAS) tool, a population-based survey on surgical conditions in low- and middle-income countries (LMICs), was performed in Sierra Leone and Rwanda. This pilot study in Nepal is the initial implementation of the SOSAS survey in South Asia. A pilot study of SOSAS, modif... | 25,189,447 | [
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Major post-operative complications predict long-term survival after esophagectomy in patients with adenocarcinoma of the esophagus. | Esophagectomy provides the best opportunity for a long-term cure despite its high post-operative morbidity. We reviewed our institutional records to evaluate the impact of major post-operative complications on the long-term survival of patients following esophagectomy after neoadjuvant treatment for locally advanced ad... | 25,189,448 | [
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Laparoscopic peritoneal dialysis catheter insertion using nitrous oxide under procedural sedation. | Laparoscopic peritoneal dialysis catheter (LPDC) implantation using nitrous oxide (N2O) pneumoperitoneum under procedural sedation is a technique that has many advantages over conventional insertion methods. The purpose of this study was to review the LPDC insertion results at our center. Data from 87 consecutive patie... | 25,189,449 | [
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Risk factors and preventive measures for acute urinary retention after rectal cancer surgery. | Although several risk factors for acute urinary retention after rectal cancer surgery have been proposed, few studies have enrolled a homogeneous group of patients without preoperative urinary dysfunction. We aimed to identify risk factors and preventive measures for acute urinary retention after rectal cancer surgery.... | 25,189,452 | [
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Long-term evolution of acute colonic diverticulitis after successful medical treatment. | The evidence is sparse concerning the natural history of acute diverticulitis after successful conservative management. This observational study aimed to evaluate the rate, severity, and need of surgery for recurrence after a first episode of acute diverticulitis successfully managed conservatively. All patients admitt... | 25,189,456 | [
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Lung squamous cell carcinomas with basaloid histology represent a specific molecular entity. | The basaloid carcinoma (pure) and the (mixed) basaloid variant of lung squamous cell carcinoma (SCC) have a dismal prognosis but their underlying specific molecular characteristics remain obscure and no therapy has proven to be efficient. To assess their molecular specificity among other lung SCCs we analyzed DNA copy ... | 25,189,482 | [
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Delay and inequality in treatment of the elderly with suspected acute coronary syndrome. | The aim of this study is to determine differences between elderly patients (≥80 years) and younger patients with suspected acute coronary syndrome (ACS) regarding delay times before diagnostic tests and treatments. All patients with chest pain who were admitted to a hospital in the Gothenburg area were included consecu... | 25,189,499 | [
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Nomadic concepts in the history of biology. | The history of scientific concepts has firmly settled among the instruments of historical inquiry. In our section we approach concepts from the perspective of nomadic concepts (Isabelle Stengers). Instead of following the evolution of concepts within one disciplinary network, we see them as subject to constant reificat... | 25,189,506 | [
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Strategic enhancement of algal biomass, nutrient uptake and lipid through statistical optimization of nutrient supplementation in coupling Scenedesmus obliquus-like microalgae cultivation and municipal wastewater treatment. | Supplementing proper nutrients could be a strategy for enhancing algal biomass, nutrients uptake and lipid accumulation in the coupling system of biodiesel production and municipal wastewater treatment. However, there is scant information reporting systematic studies on screening and optimization of key supplemented co... | 25,189,511 | [
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The effect of COD loading on the granule-based enhanced biological phosphorus removal system and the recoverability. | In this study, the effect of varied COD loading (200, 400, 500, 600 and 800 mg L(-1)) on stability and recoverability of granule-based enhanced biological phosphorus removal (EBPR) system was investigated during continuously 53-d operation. Results showed that COD loading higher than 500 mg L(-1) could obviously deteri... | 25,189,512 | [
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Preterm infants' orally directed behaviors and behavioral state responses to the integrated H-HOPE intervention. | Preterm infants are challenged by immature infant behavioral organization which may negatively influence their ability to oral feed. The purpose of this study was to determine whether the integrated H-HOPE (Hospital to Home: Optimizing the Infant's Environment) intervention would improve infant behavioral organization ... | 25,189,523 | [
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Targeting HIV latency: resting memory T cells, hematopoietic progenitor cells and future directions. | Current therapy for HIV effectively suppresses viral replication and prolongs life, but the infection persists due, at least in part, to latent infection of long-lived cells. One favored strategy toward a cure targets latent virus in resting memory CD4(+) T cells by stimulating viral production. However, the existence ... | 25,189,526 | [
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Synchronization in output-coupled temporal Boolean networks. | This paper presents an analytical study of synchronization in an array of output-coupled temporal Boolean networks. A temporal Boolean network (TBN) is a logical dynamic system developed to model Boolean networks with regulatory delays. Both state delay and output delay are considered, and these two delays are assumed ... | 25,189,531 | [
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Monensin inhibits epidermal growth factor receptor trafficking and activation: synergistic cytotoxicity in combination with EGFR inhibitors. | Targeting the EGFR, with inhibitors such as erlotinib, represents a promising therapeutic option in advanced head and neck squamous cell carcinomas (HNSCC). However, they lack significant efficacy as single agents. Recently, we identified the ability of statins to induce synergistic cytotoxicity in HNSCC cells through ... | 25,189,541 | [
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Impact of awareness drives and community-based active tuberculosis case finding in Odisha, India. | India's Revised National Tuberculosis Control programme employs passive case detection. The new sputum smear-positive case detection rate is less than 70% in Odisha State. During April-June 2012, active case finding (ACF) was conducted through awareness drives and field-based tuberculosis (TB) screening in select commu... | 25,189,560 | [
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Homoarginine and cardiovascular outcome in the population-based Dallas Heart Study. | The nonproteinogenic amino acid homoarginine has been postulated to have antiatherosclerotic effects as a weak substrate of nitric oxide synthase. This investigation in the population-based Dallas Heart Study (DHS) aimed to evaluate the association of homoarginine with clinical and subclinical cardiovascular outcomes. ... | 25,189,571 | [
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Electrophoretic and field-effect graphene for all-electrical DNA array technology. | Field-effect transistor biomolecular sensors based on low-dimensional nanomaterials boast sensitivity, label-free operation and chip-scale construction. Chemical vapour deposition graphene is especially well suited for multiplexed electronic DNA array applications, since its large two-dimensional morphology readily len... | 25,189,574 | [
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Draft Genome Sequences of Four Strains of Vibrio parahaemolyticus, Three of Which Cause Early Mortality Syndrome/Acute Hepatopancreatic Necrosis Disease in Shrimp in China and Thailand. | We sequenced four Vibrio parahaemolyticus strains, three of which caused serious acute hepatopancreatic necrosis disease. Sequence analysis of the virulent strains revealed not only genes related to cholera toxin and the type IV pilus/type IV secretion system but also a unique, previously unreported, large extrachromos... | 25,189,578 | [
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Draft Genome Sequence of Pseudomonas sp. Strain JMM, a Sediment-Hosted Environmental Isolate. | Pseudomonas sp. strain JMM was isolated from the sediments of a natural water reservoir (pH, 6 to 7) located at Chambyal village in Samba district of Jammu and Kashmir, India. Here we report the annotated draft genome sequence of strain JMM having 52 contigs with 5,884 genes and an average G+C content of 66.5%. | 25,189,587 | [
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Mi-1.2, an R gene for aphid resistance in tomato, has direct negative effects on a zoophytophagous biocontrol agent, Orius insidiosus. | Mi-1.2 is a single dominant gene in tomato that confers race-specific resistance against certain phloem-feeding herbivores including aphids, whiteflies, psyllids, and root-knot nematodes. Few prior studies have considered the potential non-target effects of race-specific resistance genes (R genes), and this paper evalu... | 25,189,594 | [
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Coronary angioplasty in octogenarians with emergent coronary syndromes: study protocol for a randomized controlled trial. | Invasive treatment (coronary angiography and intervention if feasible) of patients with acute coronary syndrome (ACS) has been shown to lead to better outcomes than medical therapy alone, but the elderly have been under-represented in many of the studies. In the elderly, medical therapy is common in ACS. Fear of compli... | 25,189,626 | [
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In situ monitoring and optimization of room temperature ultra-fast sensitization for dye-sensitized solar cells. | We describe the fastest dyeing of TiO2 photo-electrodes for dye-sensitized solar cells reported to date (<2 min) at room temperature giving η = 7.5% for an N719-SQ1-CDCA mixture which is significantly higher than devices dyed for >12 h using the same dye mixture (η = 5.5%). Time-lapse photography has been used to... | 25,189,646 | [
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Association of insulin-like growth factor-I receptor polymorphism with colorectal cancer development. | The insulin-like growth factor (IGF) system plays a prominent role in the cancer development. The IGF-1 receptor (IGF-1R) and its associated signalling pathway is an important growth regulatory pathway that has been implicated in colorectal carcinogenesis. This study was designed to compare +3179G/A IGF1R (rs 2229765) ... | 25,189,651 | [
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Identifying child abuse and neglect risk among postpartum women in Japan using the Japanese version of the Kempe Family Stress Checklist. | The aims of this study were to determine the rate of women who are high-risk for child abuse and neglect in a perinatal unit in Japan, and to identify the factors associated with risk level. To assess the potential risk for child abuse and neglect the Japanese version of the Kempe Family Stress Checklist (FSC-J) was us... | 25,189,711 | [
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It is time to change thrombosis risk assessment for PV and ET? | Polycythemia vera (PV) and essential thrombocythemia (ET) are myeloproliferative neoplasms to be diagnosed according to the WHO classification. Molecular profiling must include the analysis of JAK2 (looking for the V617F point-mutation in PV and ET, screening exon 12 for mutations only in V617F-negative PV), CALR and M... | 25,189,723 | [
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Controversies and dilemmas in allogeneic transplantation for myelofibrosis. | JAK1/2 inhibitors have broadened the therapeutic options in myelofibrosis. Though not curative, they result in a meaningful clinical benefit with relatively fewer side effects. In contrast, allogeneic hematopoietic cell transplantation (HCT) is a potentially curative option, but is associated with significant morbidity... | 25,189,727 | [
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Subjective perception of load heaviness. | This study examined human subjective perception of load heaviness. Forty-two (3 boxes × 14 weights) and 27 (3 boxes × 9 weights) experimental conditions were randomly presented to male and female participants, respectively. The results showed that the participants were not able to discriminate the effect of the box on ... | 25,189,746 | [
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Hyperplasia and fibrosis in mice with conditional loss of the TSC2 tumor suppressor in Müllerian duct mesenchyme-derived myometria. | Uterine leiomyomata are the most common tumors found in the female reproductive tract. Despite the high prevalence and associated morbidities of these benign tumors, little is known about the molecular basis of uterine leiomyoma development and progression. Loss of the Tuberous Sclerosis 2 (TSC2) tumor suppressor has b... | 25,189,766 | [
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... |
An investigation for population maintenance mechanism in a miniature garden: genetic connectivity or independence of small islet populations of the Ryukyu five-lined skink. | The Ryukyu five-lined skink (Plestiodon marginatus) is an island lizard that is even found in tiny islets with less than half a hectare of habitat area. We hypothesized that the island populations are maintained under frequent gene flow among the islands or independent of each other. To test our hypotheses, we investig... | 25,189,776 | [
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Pure germinomas of the central nervous system: treatment strategies and outcomes. | To evaluate the role of chemotherapy and radiation therapy in the treatment of pure germinomas of the central nervous system (CNS). We reviewed a historical cohort of 79 patients between the ages of 3-35 years who received definitive treatment for newly diagnosed, pure CNS germinoma between 1985 and 2010 at the Univers... | 25,189,788 | [
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Model development for naphthenic acids ozonation process. | Naphthenic acids (NAs) are toxic constituents of oil sands process-affected water (OSPW) which is generated during the extraction of bitumen from oil sands. NAs consist mainly of carboxylic acids which are generally biorefractory. For the treatment of OSPW, ozonation is a very beneficial method. It can significantly re... | 25,189,805 | [
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Dioscin inhibits adipogenesis through the AMPK/MAPK pathway in 3T3-L1 cells and modulates fat accumulation in obese mice. | Dioscin (DS) is a steroidal saponin present in a number of medicinal plants and has been shown to exert anticancer, antifungal and antiviral effects. The present study aimed to deternube the effects DS on the regulation of adipogenesis and to elucidate the underlying mechanisms. In vitro experiments were performed usin... | 25,189,808 | [
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Masturbation and Pornography Use Among Coupled Heterosexual Men With Decreased Sexual Desire: How Many Roles of Masturbation? | The relation between masturbation and sexual desire has not been systematically studied. The present study assessed the association between masturbation and pornography use and the predictors and correlates of frequent masturbation (several times a week or more often) among coupled heterosexual men who reported decreas... | 25,189,834 | [
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Blast furnace residues for arsenic removal from mining-contaminated groundwater. | In this work, blast furnace (BF) residues were well characterized and then evaluated as an adsorbent material for arsenic removal from a mining-contaminated groundwater. The adsorption process was analysed using the theories of Freundlich and Langmuir. BF residues were found to be an effective sorbent for As (V) ions. ... | 25,189,836 | [
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Removal of naphthols and analogues by the combined use of an oxidoreductase polyphenol oxidase and a biopolymer chitosan from aqueous solutions. | In this study, the combined use of an amino group-containing polymer chitosan and an oxidoreductase polyphenol oxidase (PPO) was applied to the removal of naphthols and dihydroxynaphthalenes (DHNs) from aqueous solutions. The process parameters, such as the pH value, temperature and enzyme dose, were discussed for PPO-... | 25,189,838 | [
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Biological treatment of acidic coal refuse using sulphate-reducing bacteria with chicken manure as carbon source. | The performance of using chicken manure as carbon source to promote sulphate-reducing bacteria (SRB) activity within acidic coal refuse to prevent the generation of acidic leachate was investigated in batch and column bioreactors. The bioreactors showed satisfactory performance in biological sulphate reduction, evidenc... | 25,189,842 | [
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Contemporary challenges of catheter ablation for atrial fibrillation. | Catheter ablation of atrial fibrillation (AF) is now one of the most frequently performed ablation procedures, but there are currently 2 important challenges: achieving permanent/durable rather than transient pulmonary vein isolation (PVI) and improving the results of ablation for the wider patient population with pers... | 25,189,853 | [
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Influence of body fatness distribution and total lean mass on aortic stiffness in nonobese individuals. | Subjects with normal body mass index but high body fat percentage have higher cardiovascular risk than subjects with normal weight and low fat mass. However, the association of fat distribution and lean mass with carotid-femoral pulse wave velocity (cfPWV) among nonobese apparently healthy individuals has never been as... | 25,189,869 | [
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Selected cyclic citrullinated peptides derived from the sequence of mutated and citrullinated vimentin (MCV) are targeted by different antibodies subclasses in patients with rheumatoid arthritis in Russian patients. | Antibodies against citrullinated antigens (ACPA) represent one rheumatoid arthritis (RA) classification criteria. Recently, mutated and citrullinated vimentin (MCV), containing approx. 45 potentially citrullinated sites, was characterised as another modified autoantigenic RA target. Therefore, we wanted to screen, sele... | 25,189,876 | [
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Influence of static magnetic fields combined with human insulin-like growth factor 1 on human satellite cell cultures. | Tissue engineering represents a promising research field, targeting the creation of new functional muscle tissue in vitro. The aim of the present study was to show the influence of static magnetic fields (SMF) and insulin-like growth factor-1 (IGF1), as enhancing stimuli on human satellite cell cultures, which are pref... | 25,189,891 | [
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Synergistic effect of sorafenib with ionizing radiation on human oral cancer cells. | Although anticancer effects of sorafenib on renal, liver and colon carcinomas are well-known, its combination effect with ionizing radiation on oral squamous cell carcinoma (OSCC) is unclear. Herein human SAS cells, an OSCC cell line, were used in order to elucidate this combination effect. Both SAS and SAS/nuclear fac... | 25,189,909 | [
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Progressive multifocal leukoencephalopathy--a case report and review of the literature. | Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system which affects the white matter and is caused by reactivation of the JC polyomavirus. We report the case of a 63-year-old man with chronic lymphocytic leukemia who was treated with fludarabine; rituximab and fludara... | 25,189,911 | [
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Leptin levels in women with polycystic ovaries undergoing ovarian stimulation: relation to lipoprotein profiles. | To investigate serum and follicular fluid (FF) leptin levels in normally-ovulating women and subjects with polycystic ovary syndrome (PCOS) undergoing controlled ovarian stimulation and correlate them with their lipid lipoprotein profile. We included 70 PCOS women (35 lean and 35 overweight or obese) and 76 age- and we... | 25,189,919 | [
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Postsurgical pain related to breast implant: reduction with lipofilling procedure. | After a review of clinical cases of the Unit of Plastic Surgery of the University of Siena, Italy, we found that 22 patients undergoing lipofilling for breast recontruction needed less pain drugs compared to 18 patients which did not undergo lipofilling. In this work, the postoperative pain was analyzed in two groups o... | 25,189,920 | [
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Executive deficit in spinocerebellar ataxia type 2 is related to expanded CAG repeats: evidence from antisaccadic eye movements. | Although antisaccadic task is a sensitive research tool in psychopathology, it has not been systematically studied in patients with spinocerebellar ataxia type 2 (SCA2). To identify putative biomarkers of executive dysfunction in SCA2 we assessed the antisaccade performance in 41 SCA2 patients and their sex-and-age mat... | 25,189,938 | [
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Application of immunosuppressant facilitates the therapy of optic neuritis combined with Sjögren's syndrome. | Optic neuritis (ON) is often the first symptom of multiple sclerosis (MS) and neuromyelitis optica (NMO) while there has been very little research reported on ON combined with Sjögren's syndrome (SS). The aim of this study is to provide different treatments and services for and NMO patients combined with SS. Twenty-sev... | 25,189,952 | [
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[Differential effects of diabetes education programs by levels of HbA1c and the presence of chronic complications in patients with type 1 diabetes]. | Diabetes Education Programs (DEP) that improve metabolic control are applied to a wide variety of patient types. The aim is to test whether DEPs work differently depending on the patient profile. Thirty-six type 1 diabetics participated. They were divided into four groups according to their haemoglobin levels (range: 7... | 25,189,981 | [
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Magnetic actuator for the control and mixing of magnetic bead-based reactions on-chip. | While magnetic bead (MB)-based bioassays have been implemented in integrated devices, their handling on-chip is normally either not optimal--i.e. only trapping is achieved, with aggregation of the beads--or requires complex actuator systems. Herein, we describe a simple and low-cost magnetic actuator to trap and move M... | 25,190,010 | [
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Promoter polymorphisms of miR-34b/c are associated with risk of gastric cancer in a Chinese population. | More and more evidence reveals that noncoding RNA miR-34b/c and tumor suppressor gene TP-53 independently, and/or jointly, play crucial roles in carcinogenesis. The purpose of the present hospital-based case-control study was to investigate the association between the miR-34b/c rs4938723 and TP53 Arg72Pro polymorphisms... | 25,190,020 | [
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Corneal biomechanical properties in 3 corneal transplantation techniques with a dynamic Scheimpflug analyzer. | To compare the corneal biomechanical properties of eyes that have undergone penetrating keratoplasty (PK), deep anterior lamellar keratoplasty (DALK), and Descemet stripping automated endothelial keratoplasty (DSAEK). This case-control study comprised 20 post-PK eyes, 14 post-DALK eyes, 15 post-DSAEK eyes, and 50 norma... | 25,190,024 | [
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Barriers in asthma care for pediatric patients in primary care. | There are many barriers to treating children with asthma. Barriers limit access with subsequent disturbances in quality outcomes. This study explored the difference in quality outcomes, utilization outcomes, parental knowledge, and barriers to care between children who had controlled versus uncontrolled asthma. Data we... | 25,190,036 | [
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Phosphoproteome and proteome analyses reveal low-phosphate mediated plasticity of root developmental and metabolic regulation in maize (Zea mays L.). | Phosphate (Pi) deficiency has become a significant challenge to worldwide agriculture due to the depletion of accessible rock phosphate that is the major source of cheap Pi fertilizers. Previous research has identified a number of diverse adaptive responses to Pi starvation in the roots of higher plants. In this study,... | 25,190,054 | [
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Early myocardial and skeletal muscle interstitial remodelling in systemic sclerosis: insights from extracellular volume quantification using cardiovascular magnetic resonance. | Systemic sclerosis (SSc) may induce cardiac fibrosis and systo-diastolic dysfunction. Cardiovascular magnetic resonance (CMR) can detect replacement myocardial fibrosis with late gadolinium enhancement (LGE) and interstitial myocardial fibrosis with T1 mapping techniques. The aim of the study was to detect subclinical ... | 25,190,071 | [
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Fluorescent gold nanoclusters based photoelectrochemical sensors for detection of H2O2 and glucose. | In this work, low-toxicity fluorescent gold nanoclusters (AuNCs) based photoelectrochemical sensors were developed for H2O2 and glucose detection. Herein, the processes used to fabricate the sensors and the photoelectrochemical performances of the sensors under different conditions were presented. Based on the energy b... | 25,190,086 | [
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Molecular pathophysiology of metabolic effects of antipsychotic medications. | Antipsychotic medications are associated with major metabolic changes that contribute to medical morbidity and a significantly shortened life span. The mechanisms for these changes provide us with a broader understanding of central nervous and peripheral organ-mediated metabolic regulation. This paper reviews an extens... | 25,190,097 | [
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Nuclear ING2 expression is reduced in osteosarcoma. | Osteosarcoma is a high-grade malignant bone tumor. Loss of inhibitor of growth 2 (ING2) expression has been demonstrated in numerous types of cancers. However, no study has shown the relationship between ING2 expression and osteosarcoma. In the present study, we confirmed that the levels of ING2 mRNA and protein were l... | 25,190,103 | [
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[A family with two children diagnosed with aspartylglucosaminuria-case report and literature review]. | The authors sought to investigate the clinical features and characteristics of genetic mutation in patients with aspartylglucosaminuria. Clinical data of two pediatric siblings in a family were analyzed retrospectively and relative literature was reviewed in order to study the clinical features, imaging and enzymatic c... | 25,190,167 | [
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[Cardiac catheterization and pulmonary vasoreactivity testing in children with idiopathic pulmonary arterial hypertension]. | As an important method of hemodynamic assessment in idiopathic pulmonary arterial hypertension (IPAH), cardiac catheterization combined with pulmonary vasoreactivity testing remains with limited experience in children, and the acute pulmonary vasodilator agents as well as response criteria for vasoreactivity testing re... | 25,190,170 | [
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Pharmacovigilance: empowering healthcare professionals and patients. | The European Union has thoroughly reformed its pharmacovigilance legislation in July 2012. Despite the changes, underreporting of adverse drug reactions remains a concern. This underreporting seems to be partially associated with incorrect customs and beliefs by healthcare professionals. Therefore, strengthening teachi... | 25,190,178 | [
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Sterile and microbial-associated intra-amniotic inflammation in preterm prelabor rupture of membranes. | The objectives of this study were to: (1) determine the amniotic fluid (AF) microbiology of patients with preterm prelabor rupture of membranes (PROM); and (2) examine the relationship between intra-amniotic inflammation with and without microorganisms (sterile inflammation) and adverse pregnancy outcomes in patients w... | 25,190,175 | [
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Nanosecond electric pulses: a mini-review of the present state of the art. | Nanosecond electric pulses (nsEPs) are defined as very short high intensity electric pulses which present great potential for the destabilization of intracellular structures. Their theoretical descriptions first suggested specific effects on organelles that have been confirmed by various observations both in vitro and ... | 25,190,180 | [
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Association between disease activity and risk of serious infections in subjects with rheumatoid arthritis treated with etanercept or disease-modifying anti-rheumatic drugs. | To determine the risk of serious infection in patients with rheumatoid arthritis (RA) receiving etanercept (ETN) or disease-modifying anti-rheumatic drugs (DMARDs) and to identify factors that predict a higher risk. Five-year data from the British Society of Rheumatology Biologics Register (BSRBR), a prospective observ... | 25,190,189 | [
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Stabilization of a recombinant human epidermal growth factor parenteral formulation through freeze-drying. | Development studies were performed to design a pharmaceutical composition that allows the stabilization of a parenteral rhEGF formulation in a lyophilized dosage form. Unannealed and annealed drying protocols were tested for excipients screening. Freeze-dry microscopy was used as criterion for excipients and formulatio... | 25,190,208 | [
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Sleep disorders increase the risk of burning mouth syndrome: a retrospective population-based cohort study. | Sleep disorders (SD), including apnea and nonapnea, and burning mouth syndrome (BMS) have been mutually associated with systemic diseases. Based on our research, the association between BMS and SD has not been elucidated. We determined whether SD patients have an increased risk of BMS. We used information from health i... | 25,190,261 | [
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A validated high-performance liquid chromatography method for determination of tannin-related marker constituents gallic acid, corilagin, chebulagic acid, ellagic acid and chebulinic Acid in four Terminalia species from India. | A validated rapid HPLC-PDA method was developed for identification and quantification of five tannin-related constituents gallic acid (GA), corilagin (CL), chebulagic acid (CB), ellagic acid (EA) and chebulinic acid (CN) in the extracts prepared from the bark and fruits of four Terminalia species available in India. Th... | 25,190,275 | [
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Larvicidal efficacy of Cryptomeria japonica leaf essential oils against Anopheles gambiae. | Alternative insecticidal compounds with mortality effect against mosquito life cycle stages are currently needed. The compounds should be biodegradable and nontoxic to non-targeted insects. Plant based larvicides provide effective control of vector populations. This study explored Cryptomeria japonica leaf essential oi... | 25,190,294 | [
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[Review and expert opinion in age related macular degeneration. Focus on the pathophysiology, angiogenesis and pharmacological and clinical data]. | Age related macular degeneration (AMD) is a pathological aging of the macula, brought about by the interaction of genetic and environmental factors. It induces geographic atrophy of the retina and/or choroidal neovascularization. In the latter, abnormal vessels develop from the choriocapillaris, with the involvement of... | 25,190,312 | [
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XAV939 promotes apoptosis in a neuroblastoma cell line via telomere shortening. | Telomeres, telomerase and tankyrase (TNKS) have an extremely important and special association with human cell aging and cancer. Telomerase activity is abnormally high in cancer cells and is accompanied by the overexpression of tankyrase 1 (TNKS1). TNKS1 is a positive regulator of telomerase activation and telomere ext... | 25,190,315 | [
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The cued recognition task: dissociating the abrupt onset effect from the social and arrow cueing effect. | In a standard center cueing paradigm, participants are asked to identify a target object presented either to the left or the right of a center cue (e.g., eye gaze, head-turn, arrow, etc.). When the center cue is non-predictive (e.g., the arrow points to the correct location of the target only 50 % of the time), the tar... | 25,190,323 | [
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Trends in preterm birth in singleton deliveries in a Hong Kong population. | To examine trends in preterm birth and its relationship with perinatal mortality in Hong Kong. In a retrospective cohort study, data were reviewed from singletons delivered between 1995 and 2011 at a university teaching hospital. Trends in preterm birth (between 24 and 36 weeks of pregnancy), perinatal mortality, and s... | 25,190,352 | [
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MiR-152 suppresses the proliferation and invasion of NSCLC cells by inhibiting FGF2. | MicroRNAs (miRNAs) regulate the proliferation and metastasis of cancer cells. Here, we showed that miR-152 was downregulated in non-small-cell lung cancer (NSCLC) tissues and cell lines. Overexpression of miR-152 suppressed cell proliferation and colony formation and also limited migration and invasion. Fibroblast grow... | 25,190,353 | [
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Growth, cadmium uptake and accumulation of maize (Zea mays L.) under the effects of arbuscular mycorrhizal fungi. | The effects of three arbuscular mycorrhizal fungi isolates on Cd uptake and accumulation by maize (Zea mays L.) were investigated in a planted pot experiment. Plants were inoculated with Glomus intraradices, Glomus constrictum and Glomus mosseae at three different Cd concentrations. The results showed that root coloniz... | 25,190,357 | [
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The Opposites Attract Study of viral load, HIV treatment and HIV transmission in serodiscordant homosexual male couples: design and methods. | Studies in heterosexual HIV serodiscordant couples have provided critical evidence on the role of HIV treatments and undetectable viral load in reducing the risk of HIV transmission. There is very limited data on the risk of transmission from anal sex in homosexual male serodiscordant couples. The Opposites Attract Stu... | 25,190,360 | [
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Optimal shaping of acoustic resonators for the generation of high-amplitude standing waves. | Within this paper, optimal shaping of acoustic resonators for the generation of high-amplitude standing waves through the use of evolutionary algorithms is discussed. The resonator shapes are described using sets of control points interconnected with cubic-splines. Positions of the control points are calculated by mean... | 25,190,376 | [
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Potential-based methodology for active sound control in three dimensional settings. | This paper extends a potential-based approach to active noise shielding with preservation of wanted sound in three-dimensional settings. The approach, which was described in a previous publication [Lim et al., J. Acoust. Soc. Am. 129(2), 717-725 (2011)], provides several significant advantages over conventional noise c... | 25,190,385 | [
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Cylindrical acoustical holography applied to full-scale jet noise. | Near-field acoustical holography methods are used to predict sound radiation from an engine installed on a high-performance military fighter aircraft. Cylindrical holography techniques are an efficient approach to measure the large and complex sound fields produced by full-scale jets. It is shown that a ground-based, o... | 25,190,387 | [
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Perception and automatic detection of wind-induced microphone noise. | Wind can induce noise on microphones, causing problems for users of hearing aids and for those making recordings outdoors. Perceptual tests in the laboratory and via the Internet were carried out to understand what features of wind noise are important to the perceived audio quality of speech recordings. The average A-w... | 25,190,392 | [
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A finite element model to predict the sound attenuation of earplugs in an acoustical test fixture. | Acoustical test fixtures (ATFs) are currently used to measure the attenuation of the earplugs. Several authors pointed out that the presence of an artificial skin layer inside the cylindrical ear canal of the ATFs strongly influenced the attenuation measurements. In this paper, this role is investigated via a 2D axisym... | 25,190,400 | [
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Optimizing pulse-spreading harmonic complexes to minimize intrinsic modulations after auditory filtering. | All signals, except sine waves, exhibit intrinsic modulations that affect perceptual masking. Reducing the physical intrinsic modulations of a broadband signal does not necessarily have a perceptual impact: auditory filtering can reintroduce modulations. Broadband signals with low intrinsic modulations after auditory f... | 25,190,401 | [
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The role of creaky voice in Cantonese tonal perception. | There are few studies on the role of phonation cues in the perception of lexical tones in tonal languages where pitch is the primary dimension of contrast. This study shows that listeners are sensitive to creaky phonation in native tonal perception in Cantonese, a language in which the low falling tone, Tone 4, has ane... | 25,190,405 | [
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A three-dimensional, longitudinally-invariant finite element model for acoustic propagation in shallow water waveguides. | A three-dimensional, longitudinally-invariant finite element (FE) model for shallow water acoustic propagation is constructed through a cosine transform of a series of two-dimensional FE models at different values of the out-of-plane wavenumber. An innovative wavenumber sampling method is developed that efficiently cap... | 25,190,422 | [
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Preliminary evaluation of a two-interval, two-alternative infant behavioral testing procedure. | The purpose of this study was to evaluate the feasibility and efficiency of an observer-based, two-interval forced-choice infant psychophysical testing procedure. Ten of 11 infants (7-9 months of age) achieved a criterion of 80%-correct detection of a 50-dB sound pressure level noise band in a single testing session. F... | 25,190,427 | [
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0.179983,
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Validity of hospital discharge diagnosis codes for stroke: the Atherosclerosis Risk in Communities Study. | Characterizing International Classification of Disease 9th Revision, Clinical Modification (ICD-9-CM) code validity is essential given widespread use of hospital discharge databases in research. Using the Atherosclerosis Risk in Communities (ARIC) Study, we estimated the accuracy of ICD-9-CM stroke codes. Hospitalizati... | 25,190,443 | [
-0.08502937,
0.001374038,
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0.05546303,
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0.2586143,
0.1992111,
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Synthesis and protein kinase C (PKC)-C1 domain binding properties of diacyltetrol based anionic lipids. | The protein kinase C (PKC) family of lipid-activated kinases plays a significant role in the regulation of diverse cellular functions including tumor promotion, apoptosis, differentiation, and others. The lipophilic second messenger diacylglycerols (DAGs) act as endogenous ligands for the PKCs in the presence of anioni... | 25,190,464 | [
0.09571142,
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0.3769392,
0.01620675,
0.4738524,
0.3073734,
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... |
Probiotics normalize the gut-brain-microbiota axis in immunodeficient mice. | The gut-brain-microbiota axis is increasingly recognized as an important regulator of intestinal physiology. Exposure to psychological stress causes activation of the hypothalamic-pituitary-adrenal (HPA) axis and causes altered intestinal barrier function, intestinal dysbiosis, and behavioral changes. The primary aim o... | 25,190,473 | [
-0.006847865,
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0.2266751,
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0.2757021,
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0.2001666,
-0.01719... |
Sequestration of latent TGF-β binding protein 1 into CADASIL-related Notch3-ECD deposits. | Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) represents the most common hereditary form of cerebral small vessel disease characterized by early-onset stroke and premature dementia. It is caused by mutations in the transmembrane receptor Notch3, which promote the a... | 25,190,493 | [
-0.003758135,
0.1881896,
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0.07388724,
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0.3704356,
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0.1758718,
0.1890753,
0.4895526,
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-0... |
The role of orbital ultrasonography in distinguishing papilledema from pseudopapilledema. | To determine the sensitivity and specificity of orbital ultrasonography in distinguishing papilledema from pseudopapilledema in adult patients. The records of all adult patients referred to the neuro-ophthalmology service who underwent orbital ultrasonography for the evaluation of suspected papilledema were reviewed. T... | 25,190,532 | [
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0.3421495,
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0.01973537,
-0.06949811,
0.090... |
Structural clues to UO₂²⁺/VO₂⁺ competition in seawater extraction using amidoxime-based extractants. | Here we present the first structural comparison of amidoxime complexes of UO2(2+) and VO2(+) (the main competitor in the extraction of uranium from seawater using amidoxime-based sorbents) using a 4,5-di(amidoxime)-functionalized imidazole ligand. The amidoxime groups resist tautomerization in both cases and quite diff... | 25,190,568 | [
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0.214243,
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0.09084935,
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[Protein O-GlcNAcylation and regulation of cell signalling: involvement in pathophysiology]. | O-GlcNAcylation corresponds to the addition of N-acetyl glucosamine (GlcNAc) on serine or threonine residues of cytosolic and nuclear proteins. This reversible post-translational modification regulates protein phosphorylation, sub-cellular localisation, stability and activity. Only two enzymes, OGT (O-linked N-acetyl-g... | 25,190,571 | [
0.08202507,
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0.1530634,
0.2970417,
0.1634935,
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... |
The use of a portable breath analysis device in monitoring type 1 diabetes patients in a hypoglycaemic clamp: validation with SIFT-MS data. | Monitoring blood glucose concentrations is a necessary but tedious task for people suffering from diabetes. It has been noted that breath in people suffering with diabetes has a different odour and thus it may be possible to use breath analysis to monitor the blood glucose concentration. Here, we evaluate the analysis ... | 25,190,582 | [
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0.147925,
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-0.08660... |
Perpetual conservation easements and landowners: evaluating easement knowledge, satisfaction and partner organization relationships. | Conservation easements are being more widely used to facilitate permanent land conservation. While landowners who initially place a conservation easement on their land are generally highly motivated to protect the conservation values of their land, changes in landownership may hinder long-term active landowner support ... | 25,190,596 | [
0.2845009,
0.3011957,
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0.05858229,
0.05428318,
0.07828566,
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0.0986884,
0.3358243,
-0.1857829,
-0.1242075,
0.03373066,
-0.2810751,
... |
Update on obinutuzumab in the treatment of B-cell malignancies. | The anti-CD20 mAb rituximab has revolutionized the treatment of B-cell malignancies, improving outcome for patients. Despite these improvements, the majority of patients still relapse and become refractory to rituximab. Further efforts to improve anti-CD20 mAb efficacy have recently focused on obinutuzumab /GA101, a no... | 25,190,612 | [
0.002937953,
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0.1501804,
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0.02362085,
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0.1381007,
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0.01115792,
0.02511235,
0.02196788,
0.3118213,
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... |
Metformin treatment alters memory function in a mouse model of Alzheimer's disease. | Metabolic dysfunction exacerbates Alzheimer's disease (AD) incidence and progression. Here we report that activation of the AMPK pathway, a common target in the management of diabetes, results in gender-divergent cognitive effects in a murine model of the disease. Specifically, our results show that activation of AMPK ... | 25,190,626 | [
-0.04645686,
0.02563826,
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0.157852,
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0.001765362,
0.04510172,
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Regional cingulum disruption, not gray matter atrophy, detects cognitive changes in amnestic mild cognitive impairment subtypes. | Amnestic mild cognitive impairment (aMCI), which has a high risk of progression to Alzheimer's disease (AD), can be classified into single domain (S-aMCI) and multiple domain (M-aMCI) subtypes. We investigated the integrity of regional gray matter and segments of the cingulum bundle with diffusion spectrum imaging trac... | 25,190,630 | [
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0.3267418,
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0.03297104,
0.1534684,
-0.002632196... |
Linguistic and content validation of a German-language PRO-CTCAE-based patient-reported outcomes instrument to evaluate the late effect symptom experience after allogeneic hematopoietic stem cell transplantation. | The aim of this sequential mixed methods study was to develop a PRO-CTCAE (Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events)-based measure of the symptom experience of late effects in German speaking long-term survivors of allogeneic stem cell transplantation (SCT), and to examine... | 25,190,633 | [
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0.109262,
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0.137172,
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0.09040777,
0.2477764,
0.2737905,
0.2734514,
0.2663913,
0.4769181,
0.004288043,
0... |
Characterization of circulating endothelial microparticles and endothelial progenitor cells in primary Sjögren's syndrome: new markers of chronic endothelial damage? | Chronic autoimmune diseases are associated with increased risk of cardiovascular death. Endothelial dysfunction represents the first stage of subclinical atherosclerosis and multiple factors contribute to endothelial injury. Among these, an altered balance between endothelial microparticle (EMP) release and endothelial... | 25,190,637 | [
-0.2494019,
0.1033825,
0.1292837,
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0.3091898,
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0.5993353,
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0.0660618,
0.4996888,
0.07762192,
0.1590212,
-0.01427581,
-0.... |
Restoring conjunctival tolerance by topical nuclear factor-κB inhibitors reduces preservative-facilitated allergic conjunctivitis in mice. | To evaluate the role of nuclear factor-κB (NF-κB) activation in eye drop preservative toxicity and the effect of topical NF-κB inhibitors on preservative-facilitated allergic conjunctivitis. Balb/c mice were instilled ovalbumin (OVA) combined with benzalkonium chloride (BAK) and/or NF-κB inhibitors in both eyes. After ... | 25,190,648 | [
-0.1339554,
-0.3235978,
-0.2198057,
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0.2040142,
0.0962313,
0.07622381,
0.04317961,
0.03635573,
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0.2078255,
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0.433436,
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0.2022878,
0.1383272,... |
Hepatic epithelioid hemangioendothelioma in a patient with hemochromatosis. | Hepatic epithelioid hemangioendothelioma (HEHE) is a rare hepatic vascular tumor that represents a diagnostic challenge. The rarity of this neoplasm precludes establishment of a standard-of-care treatment. Risk factors for HEHE are not well-known. Liver transplant remains the most common therapeutic modality for nonmet... | 25,190,690 | [
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0.05324547,
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0.1624216,
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0.4340227,
-0.3485903,... |
Teicoplanin therapy for MRSA bacteraemia: a retrospective study emphasizing the importance of maintenance dosing in improving clinical outcomes. | To study the relationship between teicoplanin maintenance dosing and clinical outcomes in adults with MRSA bacteraemia. MRSA bacteraemic patients who received three teicoplanin loading doses (6 mg/kg/12 h) followed by maintenance doses of 6 mg/kg/24 h (Group 1) or 6 mg/kg/12 h (Group 2) were retrospectively analysed. E... | 25,190,719 | [
0.1616905,
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0.07839282,
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0.2112506,
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0.3161633,
-0.05000217,
0.01467189,
0.0368374... |
Concurrent speed endurance and resistance training improves performance, running economy, and muscle NHE1 in moderately trained runners. | The purpose of this study was to examine whether speed endurance training (SET, repeated 30-s sprints) and heavy resistance training (HRT, 80-90% of 1 repetition maximum) performed in succession are compatible and lead to performance improvements in moderately trained endurance runners. For an 8-wk intervention period ... | 25,190,744 | [
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-0.02410607,
-0.05029485,
-0.1298159,
0.1151621,
0.002187884,
-0.1176... |
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