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Impact of maternal under nutrition on obstetric outcomes.
Maternal malnutrition, ranging from under nutrition to over dietary intake before and in the pregnant state, is worldwide problem with significant consequences, not only for survival and increased risk for acute and chronic diseases both in mother and child, but also for economic productivity of individuals in the soci...
25,194,427
[ -0.2002502, -0.04104145, 0.06049728, 0.05056578, 0.317201, -0.03414227, -0.2083247, -0.3063421, 0.3058607, -0.08235656, -0.02777874, -0.1730151, -0.307977, -0.01360781, -0.3039173, -0.1164267, -0.3718115, 0.2337648, -0.3567404, -0.3665275, -0.05304769, 0.223343, -0.359347...
Effectiveness of chamomile tea on glycemic control and serum lipid profile in patients with type 2 diabetes.
This study aimed at assessing the effects of chamomile tea consumption on glycemic control and serum lipid profile in patients with type 2 diabetes mellitus (T2DM). This single-blind randomized controlled clinical trial was conducted on 64 individuals with T2DM (males and females) aged between 30 and 60 years. The inte...
25,194,428
[ 0.07544021, 0.04480932, -0.2693141, -0.03405165, -0.1623457, -0.4559041, -0.2831591, 0.3470667, 0.1603546, -0.1808259, 0.02232472, 0.6354685, -0.3708838, -0.09113321, -0.3145269, -0.1199315, -0.1820646, 0.07037203, -0.2540216, 0.0634186, -0.2421432, 0.1074914, -0.1466854,...
Substituent effects on cooperativity of pnicogen bonds.
Substituent effects on cooperativity of P···N pnicogen bonds are studied in XH2P···NCH(2)P···NCY (X=F, Cl; Y=H, F, CN, OH, NH(2)) complexes using high-level ab initio calculations. An increased attraction or a positive cooperativity is observed on introduction of a third molecule to the XH(2)P···NCH(2)P and NCH(2)P···N...
25,194,434
[ -0.04361065, 0.2168089, -0.05627228, -0.04966939, 0.08647772, 0.02026123, -0.1830808, -0.04792236, 0.2170866, -0.05362063, -0.2032734, -0.08317814, 0.01905093, 0.01400102, -0.6493113, -0.2529953, -0.487696, 0.06404576, 0.01248197, 0.3783281, 0.1391906, 0.06652004, -0.0999...
Influence of coat colour, season and physiological status on reproduction of rabbit does in an Algerian local population.
In Algeria, rabbit meat production is small-scale, mainly on small farms with rabbits from local populations whose productivity and growth are rather low, but which are well adapted to the local environment. Of these, farmers prefer white rabbits, with the Albino or Himalayan alleles of gene C. Our objective was to ver...
25,194,435
[ 0.6252212, 0.1557886, 0.1475689, 0.08364012, -0.1940827, -0.3972607, -0.07818866, -0.0143746, 0.1310702, 0.07009736, -0.1460669, 0.2854242, 0.0001358319, 0.08916908, -0.02877626, -0.435472, -0.3957597, 0.2340687, 0.2266984, -0.06403478, 0.142782, 0.4153078, -0.007747085, ...
Association between cytosolic serine hydroxymethyltransferase (SHMT1) gene polymorphism and cancer risk: a meta-analysis.
The serine hydroxymethyltransferase (SHMT1) is the key enzyme in the folate metabolic pathway to provide one-carbon unit that plays an important role in biosynthesis. Abnormal biosynthesis involved in DNA synthesis and methylation can lead to activation of oncogenes and inactivation of tumor suppressor genes. And the a...
25,194,438
[ -0.2142076, -0.1472711, -0.2322738, -0.2521254, -0.1217489, -0.2817946, -0.05125785, -0.07238398, 0.04088639, 0.01252211, 0.311895, 0.2098755, -0.07407769, 0.4500014, -0.3802529, -0.1160051, -0.3617513, 0.194684, 0.06548817, 0.217232, 0.03967515, 0.5660151, -0.2566041, ...
Transcranial sonography and (123)I-FP-CIT single photon emission computed tomography in movement disorders.
Diagnosis of Parkinson's disease (PD) can be difficult in the early stages of the disease. The aim of the study described here was to assess the correlation between transcranial sonography (TCS) and (123)I-FP-CIT ([(123)I]ioflupane, N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-[(123)I]iodophenyl)nortropane) SPECT (single pho...
25,194,454
[ -0.2140814, -0.04752777, 0.1853229, -0.4141151, 0.4315821, -0.2115969, -0.3278258, -0.1602136, 0.02914249, 0.02123093, 0.006480079, 0.3966371, -0.1458626, -0.03978877, -0.2081421, -0.2829724, -0.437827, 0.1335359, -0.0202286, 0.3422908, -0.00602916, 0.09648542, -0.1420905...
Optimization of the integrated citric acid-methane fermentation process by air stripping and glucoamylase addition.
To solve the problem of extraction wastewater in citric acid industry, an integrated citric acid-methane fermentation process was proposed. In the integrated process, extraction wastewater was treated by mesophilic anaerobic digestion and then reused to make mash for the next batch of citric acid fermentation. In this ...
25,194,466
[ -0.2720858, 0.1516674, -0.03263197, 0.1940211, -0.1332624, 0.1542396, -0.09154432, 0.05824304, -0.1329104, 0.01590807, 0.08501702, 0.0264123, -0.08133738, -0.0408383, -0.1457049, 0.3619248, -0.7083215, -0.1743457, -0.04102109, -0.06222222, 0.269087, 0.1501167, -0.05268914...
Impaired arteriogenesis in syndecan-1(-/-) mice.
Collateral artery development (arteriogenesis) is an important compensatory response to arterial occlusion caused by atherosclerosis. The heparan sulfate proteoglycan syndecan-1 (sdc1) has previously been shown to affect the response to arterial injury but has yet been studied in arteriogenesis. We tested the hypothesi...
25,194,470
[ 0.09357103, 0.04492345, -0.1206848, 0.0146074, 0.01058608, -0.1637977, 0.13687, -0.01509654, -0.1062054, -0.08046477, -0.3033661, -0.1636235, -0.2686326, -0.3766101, -0.07072124, -0.177955, -0.1872266, -0.1218025, -0.07655564, 0.2154886, -0.2960302, 0.06022997, 0.1092732,...
Alkali and alkaline earth metallic (AAEM) species leaching and Cu(II) sorption by biochar.
Alkali and alkaline earth metallic (AAEM) species water leaching and Cu(II) sorption by biochar prepared from two invasive plants, Spartina alterniflora (SA) and water hyacinth (WH), were explored in this work. Significant amounts of Na and K can be released (maximum leaching for Na 59.0 mg g(-1) and K 79.9 mg g(-1)) f...
25,194,478
[ -0.309718, 0.3326071, -0.04872398, -0.2176564, -0.3495936, -0.003750101, -0.3217509, 0.1839094, 0.09639423, -0.07708694, -0.2684781, 0.3738477, 0.2950036, -0.4206451, -0.2935123, 0.1461966, -0.03395994, -0.001245927, 0.1334056, -0.0999204, 0.291771, 0.08710241, -0.2160005...
Prolactin modulates luteal regression from the coeliac ganglion via the superior ovarian nerve in the late-pregnant rat.
There is considerable evidence of the neuroendocrine control involved in luteal regression in the rat. In addition, circulating prolactin (PRL), which increases during the night before parturition, may gain access to the coeliac ganglion (CG), indirectly impacting the physiology of the ovary because of the known connec...
25,194,502
[ 0.09649248, -0.4009143, 0.0917092, -0.1564239, 0.04143345, -0.4512029, 0.005291118, -0.6107473, 0.1298481, 0.008466003, 0.04961732, 0.06493209, -0.1438844, -0.2611636, -0.3856443, -0.2875895, -0.6446955, -0.05991838, 0.1699825, 0.2060656, 0.05438622, 0.3092459, -0.0460002...
Fetuin-A associates with histones intracellularly and shuttles them to exosomes to promote focal adhesion assembly resulting in rapid adhesion and spreading in breast carcinoma cells.
The present analyses were undertaken to define the mechanisms by which fetuin-A modulates cellular adhesion. FLAG-tagged fetuin-A was expressed in breast carcinoma and HEK-293T cells. We demonstrated by confocal microscopy that fetuin-A co-localizes with histone H2A in the cell nucleus, forms stable complexes with hist...
25,194,507
[ 0.1560448, 0.1758678, -0.08584321, 0.2439519, 0.004578175, -0.2039277, 0.1046552, 0.3486417, 0.2148979, 0.2683443, 0.1108107, 0.1079113, -0.1592698, -0.2539857, 0.284326, -0.04624014, -0.3524788, -0.2857433, 0.1414982, -0.4333293, 0.2845982, 0.1735153, -0.2738186, -0.06...
Α2 integrin, extracellular matrix metalloproteinase inducer, and matrix metalloproteinase-3 act sequentially to induce differentiation of mouse embryonic stem cells into odontoblast-like cells.
We previously reported that interleukin 1β acts via matrix metalloproteinase (MMP)-3 to regulate cell proliferation and suppress apoptosis in α2 integrin-positive odontoblast-like cells differentiated from mouse embryonic stem (ES) cells. Here we characterize the signal cascade underpinning odontoblastic differentiatio...
25,194,508
[ -0.1893817, 0.040506, 0.05588633, 0.1064059, 0.05335223, -0.4405491, -0.2349799, 0.218078, 0.2690895, 0.08518359, -0.003499649, 0.5098103, -0.2931829, -0.2073927, 0.02069722, -0.02934227, -0.3875527, -0.02496021, -0.04783096, 0.1627438, 0.3864349, -0.09513567, -0.3441928,...
Surgical training using three-dimensional simulation in placement of cervical lateral mass screws: a blinded randomized control trial.
The skills and knowledge that residents have to master has increased, yet the amount of hours that the residents are allowed to work has been reduced. There is a strong need to improve training techniques to compensate for these changes. One approach is to use simulation-training methods to shorten the learning curve f...
25,194,517
[ -0.09645277, 0.1435859, 0.02727819, -0.1411374, -0.0918538, -0.3040966, -0.1026512, -0.350977, 0.06865858, -0.1540264, 0.1208845, 0.1458497, -0.08466732, -0.2042408, -0.6055511, 0.1363176, -0.3578309, -0.01646255, -0.411798, -0.01330159, 0.1143818, 0.1502344, -0.07827944,...
Solid waste management in the hospitality industry: a review.
Solid waste management is a key aspect of the environmental management of establishments belonging to the hospitality sector. In this study, we reviewed literature in this area, examining the current status of waste management for the hospitality sector, in general, with a focus on food waste management in particular. ...
25,194,519
[ -0.193373, 0.2417487, 0.2688336, -0.1386532, -0.173782, -0.2163635, -0.1746514, -0.06855299, -0.1400695, 0.2226642, 0.06720215, -0.1933557, -0.207733, -0.1412863, -0.06520123, 0.0524064, -0.143612, 0.02859901, 0.04734292, -0.522732, -0.4292331, 0.212414, -0.1514134, -0....
Biogenic CO2 fluxes, changes in surface albedo and biodiversity impacts from establishment of a miscanthus plantation.
Depletion in oil resources and environmental concern related to the use of fossil fuels has increased the interest in using second generation biomass as alternative feedstock for fuels and materials. However, the land use and land use change for producing second generation (2G) biomass impacts the environment in variou...
25,194,521
[ -0.2654617, 0.2355538, 0.04615343, -0.01547917, 0.04496628, 0.08067428, -0.3479132, 0.07521176, 0.1793033, 0.02102282, -0.2029545, -0.2971335, -0.1742192, -0.07496691, -0.3442304, -0.2851842, 0.1364249, 0.2180763, -0.07248191, 0.1203615, 0.1269673, 0.7717231, -0.08163779,...
Leaf optical properties are affected by the location and type of deposited biominerals.
This study aimed to relate the properties of incrusted plant tissues and structures as well as biomineral concentrations and localization with leaf reflectance and transmittance spectra from 280nm to 880nm in the grasses Phragmites australis, Phalaris arundinacea, Molinia caerulea and Deschampsia cespitosa, and the sed...
25,194,526
[ 0.3168429, -0.1581062, 0.3053559, 0.1227121, -0.09114639, -0.2524514, -0.278166, -0.2083523, 0.2163684, -0.03147028, 0.03285553, -0.1852404, 0.04094429, 0.05282915, -0.467327, 0.1803243, -0.454091, -0.1103663, -0.1503665, -0.06713009, 0.3210467, 0.4899731, -0.09687584, ...
Complex mucinous cystadenoma of undetermined malignant potential of the urachus: a rare case with review of the literature.
Urachal carcinoma is an uncommon neoplasm. Benign urachal tumours are extremely rare. All urachal mucinous tumours, regardless of tumour type, have the potential to behave in an aggressive clinical manner that includes the development of pseudomyxoma peritonei. We report a 58-year-old man who presented with lower abdom...
25,194,538
[ -0.154096, -0.04804815, -0.05990506, -0.3905199, 0.04447854, -0.4699757, -0.3579429, 0.01609399, 0.1929588, -0.008223141, 0.04997287, 0.01259749, -0.1330004, -0.009025233, -0.1745585, 0.05379668, -0.3029834, 0.06773636, 0.01267907, -0.6295587, -0.1395504, -0.237431, -0.18...
A regularization-free elasticity reconstruction method for ultrasound elastography with freehand scan.
In ultrasound elastography, reconstruction of tissue elasticity (e.g., Young's modulus) requires regularization and known information of forces and/or displacements on tissue boundaries. In practice, it is challenging to choose an appropriate regularization parameter; and the boundary conditions are difficult to obtain...
25,194,553
[ -0.05899768, 0.1643918, -0.1032756, 0.3011747, 0.1754483, -0.1714957, -0.04381698, 0.2948451, 0.07270514, 0.09784029, 0.2007828, -0.5385827, -0.09918621, 0.3782353, -0.2161579, 0.07106765, -0.252415, -0.08417041, -0.5666847, -0.2249929, 0.1665969, 0.1791381, -0.1524738, ...
Blanketing effect of expansion foam on liquefied natural gas (LNG) spillage pool.
With increasing consumption of natural gas, the safety of liquefied natural gas (LNG) utilization has become an issue that requires a comprehensive study on the risk of LNG spillage in facilities with mitigation measures. The immediate hazard associated with an LNG spill is the vapor hazard, i.e., a flammable vapor clo...
25,194,555
[ -0.1430192, 0.4725716, 0.001472094, -0.09656602, 0.185969, -0.1030462, -0.2206138, -0.213259, 0.02741524, -0.3230042, -0.1621915, -0.2985507, 0.1432515, 0.1149481, -0.1771269, -0.01040544, -0.04921241, 0.05197323, 0.234831, 0.01834469, 0.1565456, 0.4417278, -0.1002348, ...
Novel Cu₂O quantum dots coupled flower-like BiOBr for enhanced photocatalytic degradation of organic contaminant.
Here we report a highly efficient novel photocatalyst consisting of Cu2O quantum dots (QDs) incorporated into three-dimensional (3D) flower-like hierarchical BiOBr (hereafter designated QDs-Cu2O/BiOBr), which were synthesized via a simple reductive solution chemistry route and applied to decontaminate the hazardous was...
25,194,559
[ -0.06488155, 0.2261565, 0.002028406, 0.05155593, 0.1495868, -0.05376115, -0.2569894, 0.2341974, 0.09353794, 0.08623385, -0.09138817, 0.23881, -0.0482971, 0.1466007, -0.6190175, 0.07201037, -0.4232723, 0.274852, 0.18342, 0.111826, 0.2610517, 0.3737997, -0.02888665, 0.065...
Evaluation of the diagnostic work-up in children with myocarditis and idiopathic dilated cardiomyopathy.
The underlying etiology of dilated cardiomyopathy (DCM) in children varies, 14-22% is secondary to myocarditis, and the majority remains idiopathic. Etiology has prognostic value; however, 'a clinical diagnosis of myocarditis' has been frequently used because the gold standard [endomyocardial biopsy (EMB)] is often not...
25,194,576
[ -0.3252283, 0.01681608, -0.04600866, -0.3303779, 0.3449501, -0.2386978, -0.2515439, 0.2766722, -0.0569607, -0.01647779, 0.08975101, 0.4132658, 0.2304558, -0.1677077, -0.7071303, 0.06992339, -0.3393777, 0.2389075, -0.2023862, 0.3460105, 0.01564628, -0.01316324, -0.2564943,...
Randomized clinical trial: effect of Lactobacillus plantarum 299 v on symptoms of irritable bowel syndrome.
Irritable bowel syndrome (IBS) is a common diagnosis in gastroenterology. Its etiology is unknown and therapeutic options limited. Trials suggest probiotics may be beneficial. The aim of this study was to assess the symptomatic efficacy of Lactobacillus plantarum 299 v (L. plantarum 299 v) for the relief of abdominal p...
25,194,614
[ 0.02294166, -0.02685126, 0.226628, -0.07612646, -0.2076934, 0.04202779, -0.1884934, -0.0285534, 0.1041784, -0.5789303, 0.1536071, -0.243926, -0.4265462, 0.1905698, -0.1413635, -0.3299125, -0.2256096, 0.1318286, -0.08530892, 0.05115006, -0.4099381, 0.403067, 0.2165502, 0...
A simple protein-energy wasting score predicts survival in maintenance hemodialysis patients.
Nutritional status is a powerful predictor of survival in maintenance hemodialysis patients but remains challenging to assess. We defined a new Protein Energy Wasting (PEW) score based on the nomenclature proposed by the International Society of Renal Nutrition and Metabolism in 2008. This score, graded from 0 (worse) ...
25,194,620
[ 0.2130739, -0.3687781, 0.06260359, -0.2310277, 0.09568476, -0.4114273, 0.1897662, 0.2011267, -0.1032863, -0.2207105, -0.02560341, -0.3166176, 0.1486232, 0.07308288, -0.3654648, -0.3758883, -0.5943902, 0.08481604, 0.05005942, -0.1332847, -0.4276511, 0.3879927, -0.2152051, ...
Determination of furfurals in Manuka honey using piston-cylinder liquid-liquid extraction and gas chromatography.
A rapid analytical approach for the direct measurement of furfurals such as 2-furfural and 5-methyl-2-furfural at parts-per-billion level in Manuka honey is described. The approach employs a piston-cylinder based liquid-liquid extraction device using chloroform extraction solvent. This device substantially reduces extr...
25,194,623
[ 0.01174006, 0.46154, 0.2222974, -0.1391254, -0.1230199, 0.2063872, 0.0105794, 0.05175146, 0.3384926, -0.2914135, 0.2002759, -0.4901648, 0.2124957, 0.1414076, -0.4155561, -0.05377077, -0.07568294, -0.09840203, -0.04150042, 0.1454825, 0.5465443, 0.105819, -0.04711885, -0....
A three generation reproduction study with Sprague-Dawley rats consuming high-amylose transgenic rice.
The transgenic rice line (TRS) enriched with amylose and resistant starch (RS) was developed by antisense RNA inhibition of starch-branching enzymes. Cereal starch with high amylose has a great benefit on human health through its resistant starch. In order to evaluate the effect of transgenic rice on rats, the rats wer...
25,194,626
[ 0.2189125, 0.2528592, -0.1816346, -0.1241839, 0.06371186, -0.1954882, 0.004757742, 0.1908318, 0.05873191, -0.07561656, 0.09349064, -0.0534866, -0.008020354, 0.2369326, -0.3176981, -0.09148552, -0.3389716, -0.06864181, 0.0769162, 0.03745398, 0.05378396, 0.3956387, -0.28619...
Computational and mathematical methods for morphogenetic gradient analysis, boundary formation and axonal targeting.
Morphogenesis and axonal targeting are key processes during development that depend on complex interactions at molecular, cellular and tissue level. Mathematical modeling is essential to bridge this multi-scale gap in order to understand how the emergence of large structures is controlled at molecular level by interact...
25,194,659
[ -0.06426647, -0.09930532, -0.4643212, -0.01198997, 0.09612661, -0.3248534, -0.1964044, -0.06155528, 0.09184615, -0.04322179, 0.04670261, -0.3080119, -0.05890037, -0.2699863, -0.3106267, 0.1506235, -0.514784, 0.3707583, -0.01970867, -0.02698896, 0.2853397, 0.2178355, -0.03...
B2 cells suppress experimental abdominal aortic aneurysms.
Recent reports of rupture in patients with abdominal aortic aneurysm (AAA) receiving B-cell depletion therapy highlight the importance of understanding the role of B cells (B1 and B2 subsets) in the development of AAA. We hypothesized that B2 cells aggravate experimental aneurysm formation. The IHC staining revealed in...
25,194,661
[ 0.07854196, -0.1354893, -0.4904227, 0.009070061, -0.02285808, -0.3447767, 0.3296871, 0.1820318, -0.02739612, 0.04113117, 0.1205717, -0.01557582, 0.147633, 0.1313777, -0.5761904, -0.03916545, -0.01297359, 0.08417775, -0.2603621, 0.4278678, 0.3403295, 0.194761, 0.0819608, ...
Serum profiling identifies novel muscle miRNA and cardiomyopathy-related miRNA biomarkers in Golden Retriever muscular dystrophy dogs and Duchenne muscular dystrophy patients.
Duchenne muscular dystrophy (DMD) is a fatal, X-linked neuromuscular disease that affects 1 boy in 3500 to 5000 boys. The golden retriever muscular dystrophy dog is the best clinically relevant DMD animal model. Here, we used a high-thoughput miRNA sequencing screening for identification of candidate serum miRNA biomar...
25,194,663
[ -0.2924665, 0.2104889, 0.4866367, -0.6578148, -0.1262553, -0.1625467, -0.06705186, 0.3076344, -0.006183714, -0.3941807, 0.2484161, 0.2920209, -0.04646094, -0.3391023, -0.4300072, 0.02212811, -0.3533184, 0.04488674, 0.1813654, -0.4327751, 0.1691421, 0.4814646, -0.3965962, ...
Evaluating the effects of aluminum-containing and non-aluminum containing deodorants on axillary skin toxicity during radiation therapy for breast cancer: a 3-armed randomized controlled trial.
Deodorant use during radiation therapy for breast cancer has been controversial as there are concerns deodorant use may exacerbate axillary skin toxicity. The present study prospectively determined the use of both aluminum-containing and non aluminum containing deodorants on axillary skin toxicity during conventionally...
25,194,668
[ -0.02008187, 0.1507051, -0.1789279, -0.0464028, -0.1100356, -0.4185796, -0.04135298, -0.1410396, 0.02913903, -0.06853663, 0.2019492, 0.2211092, -0.1468168, -0.07836737, -0.3622837, -0.1075855, 0.0807091, 0.04231301, 0.08918184, 0.01327087, -0.1930827, 0.07602354, -0.12355...
Colon and endometrial cancers with mismatch repair deficiency can arise from somatic, rather than germline, mutations.
Patients with Lynch syndrome carry germline mutations in single alleles of genes encoding the mismatch repair (MMR) proteins MLH1, MSH2, MSH6, and PMS2; when the second allele becomes mutated, cancer can develop. Increased screening for Lynch syndrome has identified patients with tumors that have deficiency in MMR, but...
25,194,673
[ -0.1611818, 0.08531202, -0.2797538, -0.232569, -0.2832251, 0.1062193, 0.07758906, 0.2282915, 0.1387258, -0.04525688, 0.3382987, 0.5590746, -0.208543, 0.2465139, -0.1999137, 0.01917122, -0.2295931, -0.1397498, 0.1598304, 0.0203726, 0.1329309, 0.2439446, -0.04740449, -0.2...
Breathing and sense of self: visuo-respiratory conflicts alter body self-consciousness.
Bodily self-consciousness depends on the processing of interoceptive and exteroceptive signals. It can be disrupted by inducing signal conflicts. Breathing, at the crossroad between interoception and exteroception, should contribute to bodily self-consciousness. We induced visuo-respiratory conflicts in 17 subjects pre...
25,194,692
[ -0.4147513, 0.0182598, -0.007653783, -0.04557326, 0.2755358, -0.2660797, -0.6923657, -0.1247475, -0.3199061, -0.1902834, 0.3011458, 0.009897353, -0.4103305, -0.3881274, -0.536137, -0.1829257, -0.6652105, 0.1535121, -0.1378129, -0.3870852, 0.1373941, 0.234576, -0.04004274,...
Development of a skull/brain model for military wound ballistics studies.
Reports on penetrating ballistic head injuries in the literature are dominated by case studies of suicides; the penetrating ammunition usually being .22 rimfire or shotgun. The dominating cause of injuries in modern warfare is fragmentation and hence, this is the primary threat that military helmets protect the brain f...
25,194,710
[ -0.6386219, -0.08259295, 0.09226832, -0.03520998, 0.1989844, -0.4167739, -0.5381664, -0.3039021, 0.1109508, 0.2620372, 0.1696406, -0.1233727, 0.1273052, 0.1001421, -0.09270045, 0.2493761, 0.03842922, 0.5192399, -0.1435086, -0.2852947, 0.2479871, 0.05980869, 0.1541062, -...
Immunohistochemical staining reveals C-reactive protein existing predominantly as altered conformation forms in inflammatory lesions.
C-reactive protein (CRP) is an established marker of inflammation and has been proposed to play a proinflammatory role in pathologies of several diseases. CRP is primarily produced by the liver and released into circulation as a pentameric molecule composed of five identical subunits. It has been suggested that the act...
25,194,730
[ -0.02506558, 0.09216977, -0.1320816, -0.1268241, -0.08809742, -0.00862193, 0.01830216, 0.1777134, 0.229981, 0.208884, 0.08981019, -0.1465847, 0.1868277, -0.1539021, -0.1611396, -0.05461897, -0.1896325, -0.1885819, 0.01562351, 0.2764226, -0.2741977, 0.08710846, -0.07350785...
Effects of ascorbic acid on some physiological changes of pepino (Solanum muricatum Ait.) under chilling stress.
In this study, the changes caused by chilling stress on some physiological parameters of pepino (Solanum muricatum Ait.) plant and the effects of ascorbic acid (100 mM) applied exogenously on these changes were examined. For this purpose, the photosynthetic pigments (chlorophyll a, chlorophyll b, total chlorophylls and...
25,194,734
[ 0.1407747, -0.2735263, -0.09364065, -0.1500298, 0.1779942, 0.06761058, -0.3137228, 0.06709526, 0.2929219, 0.02261184, 0.1983789, 0.321638, -0.005517253, -0.05251476, -0.1409173, 0.07465756, 0.03731547, 0.1513851, -0.03582234, 0.37266, 0.0823622, 0.4674397, -0.3058372, -...
The lectin BJcuL induces apoptosis through TRAIL expression, caspase cascade activation and mitochondrial membrane permeability in a human colon adenocarcinoma cell line.
It has been demonstrated that the cytotoxic effect of BJcuL, the lectin isolated from Bothrops jararacussu venom, on human gastric carcinoma is accompanied by the inhibition of extracellular matrix adhesion, cytoskeleton disassembly and apoptosis induction. The present study aimed to evaluate the apoptosis mechanisms t...
25,194,746
[ 0.139476, -0.06558835, 0.2875912, 0.1214282, 0.475723, -0.2818942, 0.08289418, 0.1215678, 0.020456, 0.2629082, -0.1136141, -0.04326479, -0.1582645, -0.4384662, -0.4885345, 0.1829402, -0.8372642, -0.03619342, 0.07138592, -0.04697398, 0.2444064, -0.06595393, -0.4075169, 0...
Disability in patients with trapeziometacarpal joint arthrosis: incidental versus presenting diagnosis.
To test the hypothesis that there is no difference in trapeziometacarpal (TMC) joint arthrosis-related symptoms and disability between patients seeking treatment for symptoms of TMC arthrosis and those with incidental TMC joint arthrosis. We compared 64 patients presenting for care of TMC joint arthrosis with 64 with i...
25,194,769
[ -0.04660166, -0.1187474, 0.1394605, -0.1420482, -0.2270404, -0.511759, -0.01030225, 0.1350344, -0.06702647, -0.06023606, 0.0732143, -0.03515942, -0.1200006, -0.2254203, -0.1945334, -0.09721024, -0.4084453, -0.108696, -0.340278, -0.01520153, -0.4273974, -0.251581, -0.03426...
Simulation of complex transport of nanoparticles around a tumor using tumor-microenvironment-on-chip.
Delivery of therapeutic agents selectively to tumor tissue, which is referred as "targeted delivery," is one of the most ardently pursued goals of cancer therapy. Recent advances in nanotechnology enable numerous types of nanoparticles (NPs) whose properties can be designed for targeted delivery to tumors. In spite of ...
25,194,778
[ -0.0742036, -0.1610273, -0.1497184, 0.1658093, -0.04618378, 0.04552359, -0.2628104, 0.4562132, 0.0737014, 0.07623317, -0.1149097, -0.2594591, -0.2359775, -0.09291774, -0.7580326, 0.002138595, -0.2702388, -0.1576488, 0.04197924, -0.03450661, 0.05293006, 0.2536707, -0.12789...
Empirically supported methods of short-term psychodynamic therapy in depression - towards an evidence-based unified protocol.
There is evidence that psychotherapy is helpful in depressive disorders, with no significant differences between psychotherapies. For psychodynamic therapy (PDT) various models prove to be efficacious. Thus, the evidence for PDT is "scattered" between different forms of PDT, also implying problems in training of psycho...
25,194,781
[ -0.3641478, 0.1725016, 0.01082455, -0.1299737, 0.2690917, -0.2705577, -0.08166475, -0.07455101, 0.03833368, 0.3208803, 0.004038292, 0.002693375, -0.1719253, -0.2535343, -0.3909389, 0.1272953, -0.162623, 0.4499678, -0.407826, -0.05232203, 0.0075049, 0.2642931, -0.08061198,...
Disrupted topological properties of brain white matter networks in left temporal lobe epilepsy: a diffusion tensor imaging study.
Mesial temporal lobe epilepsy (mTLE) is the most common drug-refractory focal epilepsy in adults. Although previous functional and morphological studies have revealed abnormalities in the brain networks of mTLE, the topological organization of the brain white matter (WM) networks in mTLE patients is still ambiguous. In...
25,194,789
[ 0.2323933, 0.3111885, 0.1195677, 0.002173126, 0.1936216, -0.3258189, 0.1371312, -0.1941943, -0.09094264, 0.1394437, -0.1945414, 0.04357862, -0.06195822, 0.2137118, -0.2261865, 0.04692068, -0.06076996, 0.6854304, -0.1581582, -0.1056002, -0.2264883, 0.3903614, -0.07857092, ...
Hyperhomocysteinemia-induced oxidative stress differentially alters proteasome composition and activities in heart and aorta.
Hyperhomocysteinemia (HHcy) is associated with cardiovascular diseases and is thought to induce endogenous oxidative stress and causes many cellular damages. Proteasome that degrades oxidized and ubiquitinated proteins can regulate the cellular response to oxidative stress. We aimed to investigate whether hyperhomocyst...
25,194,809
[ -0.1436451, -0.2277235, 0.01137916, -0.1200865, 0.1895039, -0.3713891, 0.3495154, 0.02733653, 0.1890436, 0.233405, 0.2994572, 0.3309108, 0.1197674, 0.1783602, 0.06557558, 0.119445, -0.6805356, -0.1638187, 0.01324557, 0.2805553, 0.05029515, 0.4035514, -0.05284732, 0.2704...
Multiple sclerosis disease modifying medicine utilisation in Australia.
With the introduction of new disease modifying medicines (DMM) for relapsing remitting multiple sclerosis (RRMS) in Australia, we aimed to examine trends in utilisation from 1996 to 2013. We analysed trends in use by administrative area (state/territory). Prescription data from Medicare Australia were converted to defi...
25,194,821
[ -0.1205186, -0.06336847, -0.1443704, -0.01456381, 0.02290447, -0.1234705, 0.1293668, -0.01173892, -0.4113511, -0.1591702, -0.0891379, 0.1240552, 0.2566361, -0.01520102, 0.03814623, -0.05415362, 0.02279156, -0.1717903, 0.1457991, -0.2791984, -0.145803, 0.4497407, -0.016117...
Infant trunk posture and arm movement assessment using pressure mattress, inertial and magnetic measurement units (IMUs).
Existing motor pattern assessment methods, such as digital cameras and optoelectronic systems, suffer from object obstruction and require complex setups. To overcome these drawbacks, this paper presents a novel approach for biomechanical evaluation of newborn motor skills development. Multi-sensor measurement system co...
25,194,825
[ -0.07835175, 0.1433798, -0.01985909, -0.05882275, 0.3913068, -0.3813201, -0.1060469, -0.2802581, 0.2307817, 0.09073948, -0.1353578, -0.7899203, -0.2201309, 0.1359037, -0.2520128, 0.2499293, -0.380257, 0.1759537, -0.5378999, -0.142266, 0.4235861, 0.008649647, 0.04964058, ...
Maternal sounds elicit lower heart rate in preterm newborns in the first month of life.
The preferential response to mother's voice in the fetus and term newborn is well documented. However, the response of preterm neonates is not well understood and more difficult to interpret due to the intensive clinical care and range of medical complications. This study examined the physiological response to maternal...
25,194,837
[ 0.1239632, -0.1052671, -0.6333259, -0.1413062, 0.1791859, -0.1392467, -0.1986846, -0.2385898, 0.1661473, -0.5063487, 0.03135892, -0.124813, -0.003454624, -0.3032806, -0.005166618, 0.007823789, -0.521487, -0.09957449, -0.213773, -0.2691523, -0.01526962, 0.1116496, -0.11778...
Annual gonadal cycles in birds: modeling the effects of photoperiod on seasonal changes in GnRH-1 secretion.
This paper reviews current knowledge of photoperiod control of GnRH-1 secretion and proposes a model in which two processes act together to regulate GnRH1 secretion. Photo-induction controls GnRH1 secretion and is directly related to prevailing photoperiod. Photo-inhibition, a longer term process, acts through GnRH1 sy...
25,194,876
[ -0.216704, -0.1421468, -0.2967671, -0.3720717, 0.2818468, -0.3434138, -0.08441871, -0.1620147, 0.2424772, 0.07944647, 0.08194754, 0.184551, 0.01332787, -0.2269981, -0.2515369, -0.1563536, -0.4050733, 0.2703671, 0.031083, -0.2356019, 0.212831, 0.3289892, -0.3467545, -0.1...
Global change effects on biogeochemical processes of Argentinian estuaries: an overview of vulnerabilities and ecohydrological adaptive outlooks.
The aims of this work are to provide an overview of the current stresses of estuaries in Argentina and to propose adaptation strategies from an ecohydrological approach. Several Argentinian estuaries are impacted by pollutants, derived mainly from sewage discharge and agricultural or industrial activities. Anthropogeni...
25,194,878
[ -0.1653304, -0.04698879, 0.1303565, 0.08458631, -0.3977058, -0.1619334, -0.005148188, -0.2277588, 0.1978895, 0.06039358, -0.08915021, -0.5252879, -0.2866877, -0.1817531, -0.1907708, -0.2312922, -0.3241342, 0.1377441, 0.2632626, -0.07413281, -0.05103401, 0.4948213, -0.2712...
Rapid detection and high occurrence of porcine rotavirus A, B, and C by RT-qPCR in diagnostic samples.
Rotaviruses are important cause of diarrhea in animals, including humans. Currently, rotavirus species A, B, C, E, and H (RVA-RVC, RVE, and RVH) have been identified in pigs. Traditionally, RVA has been considered the primary cause of diarrhea in pigs, and RVB and RVC had been described sporadically in pigs until recen...
25,194,889
[ -0.009807391, -0.2246131, 0.1128722, -0.06311589, 0.09479131, -0.1417184, -0.161906, 0.04989113, -0.1379359, -0.204682, 0.3025382, 0.3276554, -0.1160058, 0.01647527, -0.2950835, -0.3501524, -0.3175877, 0.211335, 0.330104, -0.08990052, 0.07267773, 0.2180047, -0.1104103, ...
Mecoprop (MCPP) removal in full-scale rapid sand filters at a groundwater-based waterworks.
Contamination by the herbicide mecoprop (MCPP) was detected in groundwater abstraction wells at Kerteminde Waterworks in concentrations up to 0.08μg/L. MCPP was removed to below detection limit in a simple treatment line where anaerobic groundwater was aerated and subsequently filtered by primary and secondary rapid sa...
25,194,903
[ -0.2375581, 0.1354414, 0.109755, -0.1983594, -0.2049079, 0.1435232, -0.3627683, 0.2176715, 0.1782095, 0.1806138, -0.03498438, 0.0356436, 0.03532637, 0.2729821, -0.4157193, -0.06994013, -0.6410353, 0.1265636, 0.02108053, 0.336803, -0.09982159, 0.2222251, -0.005299627, 0....
Quantification of neonicotinoid insecticide residues in soils from cocoa plantations using a QuEChERS extraction procedure and LC-MS/MS.
The use of neonicotinoids as an insecticide group in Ghana has been quite significant particularly in cocoa production. The high usage has been mainly as a result of a government policy of free insecticide spraying on cocoa farms, in an effort to curb declining yields caused by pests and diseases and to prevent the use...
25,194,905
[ 0.1882493, 0.1690119, 0.1979353, 0.1009447, -0.06306522, -0.2245185, -0.006032156, 0.1972931, 0.03747129, -0.3522986, 0.1245341, -0.007986857, 0.2301249, 0.1922934, -0.1281288, 0.04003626, -0.4406256, -0.09312128, 0.0191245, 0.1272757, 0.09327514, -0.02525867, -0.2849172,...
The hydrological behaviour of extensive and intensive green roofs in a dry climate.
This paper presents the results of a hydrological investigation of four medium scale green roofs that were set up at the University of South Australia. In this study, the potential of green roofs as a source control device was investigated over a 2 year period using four medium size green roof beds comprised of two gro...
25,194,906
[ -0.05271675, 0.3418811, -0.1189487, 0.123381, 0.02511928, -0.298255, -0.152744, -0.1240167, -0.056132, 0.04272351, -0.2426638, -0.1580678, -0.09591544, 0.2070149, 0.03422471, 0.09818299, -0.1306453, 0.138124, 0.1893798, -0.2528205, 0.1615905, 0.1157587, -0.07134219, 0.2...
Long-term clinical outcomes after sirolimus-eluting stent implantation for unprotected left main coronary artery disease.
Previous studies reporting long-term (≥5 year) clinical outcome in patients with unprotected left main coronary artery (LMCA) disease undergoing drug-eluting stent (DES) implantation are currently limited, although late adverse events beyond 1 year are one of the major concerns of DES. We evaluated long-term clinical o...
25,194,953
[ 0.1902413, 0.3742541, 0.1904091, 0.0426066, 0.138855, -0.2135416, 0.3219792, -0.2506005, 0.127803, -0.1630063, -0.2214276, 0.1243236, -0.1050007, 0.2196338, 0.006321468, -0.2061231, -0.1882906, 0.3251191, 0.2882857, -0.006613486, 0.1961286, 0.3750401, -0.06181649, 0.122...
The promise of copper lowering therapy with tetrathiomolybdate in the cure of cancer and in the treatment of inflammatory disease.
Tetrathiomolybdate (TM) is a unique anticopper drug developed for the treatment of the neurologic presentation of Wilson's disease, for which it is excellent. Since it was known copper was required for angiogenesis, TM was tested on mouse cancer models to see if it would inhibit tumor growth based on an antiangiogenic ...
25,194,954
[ -0.3472807, 0.207848, -0.08695323, -0.6530576, -0.3359321, -0.3983678, -0.06291338, 0.3896351, -0.1399536, -0.03025776, -0.2271779, 0.3056356, 0.2331787, -0.406369, -0.5849937, 0.141316, 0.1897315, 0.4269191, -0.2257875, 0.4257763, -0.07208234, -0.01768829, -0.09084453, ...
Adipose tissue chromium and vanadium disbalance in high-fat fed Wistar rats.
The primary objective of the current study is to investigate the relationship between adipose tissue chromium and vanadium content and adipose tissue dysfunction in a model of diet-induced obesity. A total of 26 female Wistar rats were fed either standard or high-fat diet (31.6% of fat from total caloric content) for 3...
25,194,956
[ 0.3106261, -0.06866948, -0.2514079, 0.2014947, 0.2535715, -0.2918167, -0.08395506, 0.4097624, -0.2130263, 0.3345532, -0.0186804, -0.007634304, -0.06122715, 0.02208902, -0.08274499, -0.2242423, 0.04529136, 0.07922242, 0.02142456, 0.03741272, -0.2763594, 0.07482116, -0.1011...
The role of cystatin C in the prognosis of adverse outcomes after the coronary artery bypass graft surgery during hospitalisation.
This study has been aimed to assess clinical significance of cystatin C in the prognosis of a risk of hospital complications among the patients with coronary artery disease CAD who have undergone coronary artery bypass surgery (CABG). We have recruited 719 consecutive Caucasian (Russian) patients who underwent CABG in ...
25,194,959
[ 0.05320276, -0.2290685, -0.1735968, -0.3793173, -0.1127794, -0.3046451, 0.007656015, 0.09003372, -0.04769379, 0.2429228, -0.1598075, 0.2169531, -0.01763403, -0.08387409, 0.2924057, -0.1227951, -0.1719655, -0.01552405, -0.04249492, 0.06975058, 0.2150795, 0.1335004, -0.1139...
Association between fruit and vegetable intake and risk for glioma: a meta-analysis.
Epidemiologic studies evaluating the association between the intake of vegetables and fruit and the risk for glioma have produced inconsistent results. Therefore, the aim of this study was to test the hypothesis that higher vegetable and fruit intake may have a protective effect on risk for glioma. Pertinent studies we...
25,194,962
[ -0.2294815, 0.1383769, -0.1517454, -0.1784158, 0.2084079, -0.3199113, -0.4354455, -0.1393204, 0.03348964, -0.06577874, 0.06802809, 0.6133127, 0.05541496, 0.09518771, -0.1864141, -0.1541247, -0.3668254, 0.6467994, -0.1050545, -0.3038897, -0.3059725, 0.2400151, -0.2610953, ...
Disease as a theoretical concept: the case of "HPV-itis".
If there is any value in the idea that disease is something other than the mere absence of health then that value must lie in the way that diseases are classified. This paper offers further development of a view advanced previously, the Contrastive Model of Disease: it develops the account to handle asymptomatic diseas...
25,194,981
[ -0.4173994, -0.3039367, -0.3438201, 0.1790105, 0.3181334, -0.201861, -0.3743646, 0.1882356, 0.125489, -0.1413364, 0.1807915, 0.5097513, 0.0212067, -0.3331846, -0.3906383, -0.06544141, -0.2199499, 0.09118208, -0.1247794, -0.0427287, 0.1744792, 0.1457609, -0.1226549, 0.31...
The initial experience of pneumovesicoscopic bladder stone removal using a laparoscopic entrapment sac.
In this article, we aim to present our novel experience of bladder stone removal under pneumovesicoscopic field using a laparoscopic entrapment sac. We retrospectively reviewed the medical records of 21 patients who had pneumovesicoscopic bladder stone removal to assess a variety of patient characteristics and surgical...
25,194,995
[ 0.0890538, 0.00259514, -0.2182544, 0.08875483, -0.06959631, -0.303498, -0.1191577, -0.3817286, -0.01194217, -0.04541874, 0.04261599, -0.1757469, -0.2335867, -0.04213193, -0.2096271, -0.152531, -0.140186, 0.07032423, 0.2833498, -0.4628787, -0.1009416, 0.182828, -0.092901, ...
A gold nanoparticle-linked glycoconjugate vaccine against Burkholderia mallei.
Burkholderia mallei are Gram-negative bacteria, responsible for the disease glanders. B. mallei has recently been classified as a Tier 1 agent owing to the fact that this bacterial species can be weaponised for aerosol release, has a high mortality rate and demonstrates multi-drug resistance. Furthermore, there is no l...
25,194,998
[ -0.1052306, -0.2736677, 0.2824509, -0.1469598, -0.3322717, -0.04554078, -0.3257349, -0.06325343, -0.1710859, 0.239076, 0.3068582, 0.09716534, -0.1374677, -0.1360866, -0.3711419, 0.1225613, -0.3470125, 0.01230731, 0.1016663, -0.4409375, -0.1611091, 0.002282744, -0.2142306,...
Modeling nucleotide excision repair and its impact on UV-induced mutagenesis during SOS-response in bacterial cells.
A model of the UV-induced mutation process in Escherichia coli bacteria has been developed taking into account the whole sequence of molecular events starting from initial photo-damage and finishing with the fixation of point mutations. The wild-type phenotype bacterial cells are compared with UV-sensitive repair-defic...
25,195,002
[ -0.1130508, -0.2854737, -0.1322459, -0.02513498, 0.175945, -0.4128945, 0.04769482, 0.1089255, 0.3663927, 0.1028478, 0.2609364, 0.06697779, -0.224638, -0.0002331933, -0.6756884, -0.1790754, -0.3026097, 0.1291835, -0.01464338, 0.226486, 0.4446302, 0.2747003, -0.3262683, -...
A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics.
Activation of the ERK pathway is a hallmark of cancer, and targeting of upstream signaling partners led to the development of approved drugs. Recently, SCH772984 has been shown to be a selective and potent ERK1/2 inhibitor. Here we report the structural mechanism for its remarkable selectivity. In ERK1/2, SCH772984 ind...
25,195,011
[ -0.09272859, 0.0583393, -0.3790226, -0.2695147, 0.09095868, -0.08606672, -0.2290493, 0.3019349, 0.186754, 0.07076565, -0.1746411, 0.09618644, 0.1082062, -0.09455799, -0.3070985, -0.1574854, -0.3212109, 0.06370604, -0.1499329, -0.02001481, 0.2697808, 0.191792, -0.04017157,...
Nuclear imaging: a powerful novel approach for tuberculosis.
Nearly 20 years after the World Health Organization declared tuberculosis (TB) a global public health emergency, TB still remains a major global threat with 8.6 million new cases and 1.3 million deaths annually. Mycobacterium tuberculosis adapts to a quiescent physiological state, and is notable for complex interaction...
25,195,017
[ -0.2423697, -0.04554971, 0.1114511, -0.1791833, -0.3314207, -0.1640526, -0.238265, 0.09289126, 0.1994542, -0.1640471, -0.0247512, -0.194856, -0.05922329, 0.07161491, -0.5051971, -0.2407243, -0.2804727, 0.09591337, 0.07852505, 0.02937803, 0.2115438, 0.3339582, -0.1914264, ...
Use of mep HyperCel for polishing of human serum albumin.
The manufacture of human serum albumin by chromatographic procedures involves gel filtration chromatography as a final polishing step. Despite this step being essential to remove high molecular weight impurity proteins and thus ensure a stable and safe final product, it is relatively inefficient. This paper explores th...
25,195,026
[ -0.2227651, -0.1570534, 0.1278128, -0.2977722, 0.1851522, -0.009424673, -0.0417782, -0.09217999, 0.06946977, 0.4014935, -0.3106399, -0.05583845, -0.08635575, 0.2241806, -0.3960073, 0.1065384, -0.1083521, -0.1974093, 0.03964559, 0.09913706, 0.1774942, 0.1069051, -0.1470978...
Development of soils and communities of plants and arbuscular mycorrhizal fungi on West Virginia surface mines.
Surface mining followed by reclamation to pasture is a major driver of land use and cover change in Appalachia. Prior research suggests that many aspects of ecosystem recovery are either slow or incomplete. We examined ecosystem structure-including soil physical and chemical properties, arbuscular mycorrhizal fungal (A...
25,195,033
[ -0.149658, -0.01726273, -0.03812987, -0.01050527, -0.1968445, -0.0524528, -0.5004681, 0.102208, 0.3447767, -0.02433426, -0.2821338, -0.3897933, 0.102849, 0.1275058, -0.3101833, 0.07753871, -0.1678098, 0.2687042, 0.3076853, -0.169478, -0.02435169, 0.3308449, -0.1907296, ...
A novel osteotomy in shoulder joint replacement based on analysis of the cartilage/metaphyseal interface.
The accuracy of reconstruction is thought to impact on functional outcome following glenohumeral joint arthroplasty. The objective of this study was to define an area of minimal anatomic variation at the cartilage/metaphyseal interface of the proximal humerus to optimize the osteotomy of the humeral head, enabling accu...
25,195,075
[ -0.2465762, 0.1462245, -0.07207148, -0.09328129, -0.4346315, -0.228031, -0.08458138, 0.4181083, 0.3937902, 0.1595148, 0.2623421, -0.303354, -0.2270996, -0.6439307, -0.07791418, 0.01789775, -0.0372999, -0.1342703, -0.1439519, -0.005236705, -0.01929364, 0.1684079, 0.0812557...
[Brachytherapy in France: current situation and economic outlook due to the unavailability of iridium wires].
In 2013, about 6000 patients were treated with brachytherapy, the number diminishing by 2.6% per year since 2008. Prostate, breast and gynecological cancers are the most common types of cancers. Since 2008, the number of brachytherapy facilities has decreased by 18%. In medicoeconomic terms, brachytherapy faces many pr...
25,195,115
[ -0.1496079, -0.02744831, 0.0219438, 0.3019541, 0.01973515, -0.3123145, 0.06837025, -0.1890225, 0.01517585, 0.3581926, 0.1315431, -0.07768467, -0.1412128, -0.09524526, -0.2706142, -0.4897834, 0.3623094, -0.1319787, -0.133372, -0.2208172, 0.6040255, -0.02245319, -0.00936774...
Rituximab therapy for hairy cell leukemia: a retrospective study of 41 cases.
The purine analogs (PAs) cladribine and pentostatin have transformed the prognosis of hairy cell leukemia (HCL). However, some patients still relapse after PAs, or fail to reach an optimal response, and new agents are needed to further improve treatment outcome. We retrospectively studied 41 HCL patients from 10 center...
25,195,120
[ 0.2763125, -0.1713762, -0.2571194, 0.05522647, 0.1883215, -0.2289072, 0.218083, 0.03739123, -0.2789477, 0.04570997, 0.02449086, 0.1928058, 0.1339258, 0.1885123, -0.06927893, -0.3777801, -0.08453113, -0.05810842, -0.04151098, 0.1958898, 0.344473, -0.1111787, -0.2773578, ...
Exploring self-compassion as a refuge against recalling the body-related shaming of caregiver eating messages on dimensions of objectified body consciousness in college women.
Guided by an overarching body-related shame regulation framework, the present investigation examined the associations between caregiver eating messages and dimensions of objectified body consciousness and further explored whether self-compassion moderated these links in a sample of 322 U.S. college women. Correlational...
25,195,124
[ -0.3233134, 0.2256504, -0.08195734, -0.2874966, 0.2329879, -0.4958882, -0.06107157, -0.3549414, 0.2287416, -0.1729528, -0.006796776, 0.003871969, -0.2578215, -0.2407506, -0.02720539, -0.100832, -0.729594, -0.03860581, -0.05921641, -0.2177716, -0.2181684, 0.06782532, -0.39...
NIR luminescence for the inspection of thermal paper: a novel tool for fingermarks detection.
The near infrared (NIR) spectral region could offer advantages over the visible region in the detection of latent fingermarks due to the enhanced contrast between the background and the print. In this present paper, this spectral range of the electromagnetic spectrum was explored in order to study the possibility to ma...
25,195,127
[ -0.00773331, 0.3503518, -0.01055274, 0.06390824, -0.04060739, 0.1580974, -0.09774049, 0.06157285, 0.3247476, 0.05121822, -0.07794722, -0.003898861, 0.1000287, -0.1253835, -0.4879722, -0.0212091, -0.3982272, 0.1567768, -0.1209275, -0.03297934, 0.4128368, 0.2850249, -0.1749...
Cationic surface charge enhances early regional deposition of liposomes after intracarotid injection.
Rapid first pass uptake of drugs is necessary to increase tissue deposition after intraarterial (IA) injection. Here we tested whether brain tissue deposition of a nanoparticulate liposomal carrier could be enhanced by coordinated manipulation of liposome surface charge and physiological parameters, such as IA injectio...
25,195,130
[ -0.2187603, 0.1596583, -0.2903946, -0.09583438, 0.3953476, -0.1192744, -0.1377359, -0.1035527, 0.09120628, 0.2081915, -0.06810452, 0.1164697, 0.02718292, -0.1572678, -0.2356701, -0.104758, -0.5067288, 0.02353107, -0.2016619, -0.2356359, 0.1518755, 0.396284, 0.01533674, ...
The meiotic-mitotic initiation switch in budding yeast maintains its function robustly against sensitive parameter perturbations.
Experiments show that the meiotic-mitotic initiation switch in budding yeast functions robustly during the early hours of meiosis initiation. In this study, we explain these experimental observations first by understanding how this switching occurs during the early hours of meiosis by studying the temporal variation of...
25,195,149
[ 0.103315, -0.3270427, -0.09216902, -0.184834, 0.1265246, -0.103007, 0.0193251, 0.1640596, 0.207455, -0.02770075, -0.1981563, -0.03352416, -0.07308889, 0.08053218, -0.7008398, -0.0960265, -0.2904963, -0.2989465, -0.1157076, -0.01986383, 0.4866278, 0.3211805, -0.04783997, ...
Pediatricians' self-reported knowledge, attitudes, and practices about child passenger safety.
To evaluate pediatricians' self-reported knowledge, attitudes, and dissemination practices regarding the new American Academy of Pediatrics' (AAP) child passenger safety (CPS) policy recommendations. A cross-sectional survey was distributed to pediatric primary care physicians via AAP e-mail distribution lists. Knowled...
25,195,160
[ -0.1989166, -0.0504851, -0.2466895, -0.2713106, 0.1914972, 0.1049143, -0.06130919, 0.10543, -0.07504569, -0.03336343, 0.2061644, 0.1728243, -0.005983195, 0.2623222, -0.1859914, -0.2101827, -0.4008889, 0.06909546, -0.2263472, -0.1527287, 0.2943867, 0.14352, -0.1208895, -...
Genotype-environment correlation in the era of DNA.
One of John Loehlin's many contributions to the field of behavioral genetics involves gene-environment (GE) correlation. The empirical base for GE correlation was research showing that environmental measures are nearly as heritable as behavioral measures and that genetic factors mediate correlations between environment...
25,195,166
[ 0.06909795, 0.1696659, -0.2188199, -0.06709044, 0.004894846, -0.1663168, -0.3857476, -0.05891601, 0.01385491, 0.21368, 0.03116846, 0.2748465, 0.04301412, -0.1475703, -0.4338766, 0.2165571, 0.06409868, -0.1145048, 0.2788397, 0.3818402, 0.2722869, -0.04944321, -0.1764829, ...
Design and construction of a thermal neutron beam for BNCT at Tehran Research Reactor.
An irradiation facility has been designed and constructed at Tehran Research Reactor (TRR) for the treatment of shallow tumors using Boron Neutron Capture Therapy (BNCT). TRR has a thermal column which is about 3m in length with a wide square cross section of 1.2×1.2m(2). This facility is filled with removable graphite...
25,195,172
[ -0.1876632, 0.02558722, -0.146914, 0.1040795, 0.0352299, -0.1973802, -0.03697075, 0.01470861, 0.02792498, 0.3810662, -0.1417076, -0.3585743, 0.1560785, 0.2212877, -0.3060632, -0.4674034, -0.1452724, -0.2006331, 0.1281108, -0.2523219, 0.1807197, 0.4882832, 0.07018113, 0....
Purification, characterization and structure of nucleoside diphosphate kinase from Drosophila melanogaster.
Nucleoside diphosphate kinase (NDPK) is a ubiquitous enzyme found in all organisms and cell types, which catalyzes the transfer of the phosphoryl group from a nucleoside triphosphate to a nucleoside diphosphate. The gene encoding for NDPK from Drosophila melanogaster was amplified from the genomic DNA. The recombinant ...
25,195,176
[ -0.005540735, -0.04834795, -0.1127759, 0.0293834, 0.08271921, -0.2204339, -0.3237595, 0.064165, 0.11919, -0.1589783, 0.243175, -0.0401814, -0.1182161, -0.01011697, -0.6843299, 0.09905808, -0.5980747, 0.04837142, 0.03473228, -0.04511201, 0.3995941, 0.0710659, -0.2083519, ...
Tumor pathology of the orbit.
The term orbital tumor covers a wide range of benign and malignant diseases affecting specific component of the orbit or developing in contact with them. They are found incidentally or may be investigated as part of the assessment of a systemic disorder or because of orbital signs (exophthalmos, pain, etc.). Computed t...
25,195,185
[ -0.1452726, -0.1450778, -0.3382354, -0.2049561, 0.05740066, -0.4232723, -0.06713663, -0.03124338, -0.1476186, -0.01584167, 0.1330464, -0.3029271, -0.1969825, -0.3536392, -0.3325063, -0.1048376, -0.5694971, 0.1283625, 0.4675868, 0.0594205, 0.06542662, -0.03215891, -0.48841...
Advances in algal drug research with emphasis on enzyme inhibitors.
Enzyme inhibitors are now included in all kinds of drugs essential to treat most of the human diseases including communicable, metabolic, cardiovascular, neurological diseases and cancer. Numerous marine algae have been reported to be a potential source of novel enzyme inhibitors with various pharmaceutical values. Thu...
25,195,189
[ -0.1256821, -0.2140253, -0.1002966, -0.2760621, 0.01481027, -0.08114981, -0.1142955, 0.4772801, 0.2691301, 0.009597413, -0.008465325, -0.2890668, 0.05438467, 0.04273739, -0.3675981, 0.5473884, -0.3040326, 0.5042568, -0.05220923, 0.3746093, -0.05049047, 0.06690352, -0.3639...
Australian bat lyssavirus infection in two horses.
In May 2013, the first cases of Australian bat lyssavirus infections in domestic animals were identified in Australia. Two horses (filly-H1 and gelding-H2) were infected with the Yellow-bellied sheathtail bat (YBST) variant of Australian bat lyssavirus (ABLV). The horses presented with neurological signs, pyrexia and p...
25,195,190
[ -0.2240075, -0.07021961, -0.08693308, -0.1229087, 0.02846068, -0.1245336, -0.04503915, -0.2265462, 0.1505786, -0.2944318, 0.251041, 0.3866492, 0.3738509, 0.05749739, -0.1828711, -0.3848117, -0.06392641, -0.06922661, -0.1923423, 0.136118, -0.01890948, 0.255416, -0.11912, ...
Circulating endometrial cells in peripheral blood.
Endometriosis is a common disorder amongst women of reproductive age. Despite extensive research, no reliable blood tests currently exist for the diagnosis of endometriosis We report several new approaches enabling study of cell specific characteristic of endometrial cells, introducing enrichment and culturing of viabl...
25,195,200
[ -0.004038581, 0.1390995, 0.1783887, -0.2210797, -0.04277007, -0.09962802, -0.1071327, 0.2422575, 0.02922881, 0.2483274, -0.2257138, 0.1499748, -0.03830088, -0.04001709, -0.3297315, -0.1952716, -0.2510702, 0.1541511, -0.1256705, 0.1898559, 0.4136407, 0.3440218, -0.1596312,...
Potential maternal symptomatic benefit of gabapentin and review of its safety in pregnancy.
Restless legs syndrome (RLS) and nausea and vomiting of pregnancy (NVP) are both common maternal conditions affecting quality of life. Gabapentin is currently FDA-approved for treating RLS and preliminary results have shown it may be effective for treating the most severe form of NVP, hyperemesis gravidarum (HG). Becau...
25,195,202
[ -0.07746968, -0.1412674, -0.3604913, -0.1519175, 0.1713025, -0.1051694, 0.09662678, -0.576181, 0.131229, -0.1635069, 0.01900162, 0.1186027, -0.01442496, 0.2674955, -0.209225, -0.01940662, -0.5800734, 0.3369644, 0.2823903, -0.08158743, -0.4675697, 0.5480933, -0.1673879, ...
[Construction of transgenic tobacco expressing popW and analysis of its biological phenotype].
In a previous study, we cloned popW from Ralstonia solanacearum strain ZJ3721, coding PopW, a new harpin protein. The procaryotically expressed PopW can induce resistance to Tobacco mosaic virus (TMV), enhance growth and improve quality of tobacco, when sprayed onto tobacco leaves. Here, we constructed an expression ve...
25,195,247
[ 0.2065134, -0.1413685, -0.4452243, 0.06930275, -0.1109684, -0.4335606, -0.2257793, 0.308011, 0.09239563, -0.1360919, 0.1795606, -0.05671982, 0.1372581, 0.07270282, -0.1654373, -0.1654075, -0.1605269, -0.09370522, -0.008386781, -0.09968861, -0.2432852, 0.7162685, -0.288196...
[Optimization of coding sequences and expression of antimicrobial peptide magainin II in Escherichia coli and Pichia pastoris].
The antimicrobial peptide magainin II is expressed in the skin of the African clawed frog, Xenopus laevis, and exhibits a broad spectrum of antimicrobial activity as well as tumoricidal properties at low concentrations. In addition, magaininII plays a synergistic role during antimicrobial and tumoricidal processes with...
25,195,251
[ 0.2182787, -0.1855202, -0.2338571, 0.2287228, 0.1255039, 0.1749175, -0.2868825, 0.2791172, 0.3284628, -0.2064391, 0.01444804, -0.2559337, 0.1372619, 0.1315003, -0.2804765, -0.1924344, -0.6321784, -0.296568, -0.02737109, 0.08079695, 0.743451, 0.06324022, -0.07751474, 0.3...
[Expression of ns1 gene from Bombyx mori bidensovirus by a novel baculovirus expression system].
Baculovirus gene expression is the most popular method to make target protein in cultured insect cells. To fast determine the generation of recombinant virus in cultured cells, donor plasmid of pFastBacI was modified by introducing egfp cassette. In the modified vector, egfp cassette was under the control of ie1 promot...
25,195,252
[ -0.2588142, 0.05348939, -0.09289204, 0.02160677, 0.3243524, -0.2568342, 0.04590404, -0.1465534, -0.1172927, 0.00252207, 0.07968117, -0.2784289, -0.05906826, 0.08147053, -0.426948, -0.3671314, -0.2572197, 0.08954909, 0.0589348, 0.2109439, 0.2073126, 0.5039363, 0.1513796, ...
[Optimization and application of chemically defined medium for 13C metabolic flux analysis of Streptomyces rimosus M4018].
The aim of this study is to develop a synthetic medium suitable for 13C metabolic flux analysis (13C-MFA) of Streptomyces rimosus. The cell growth rate and oxytetracycline production by S. rimosus M4018 were compared when M4018 cells were growth on the optimized chemically defined media with organic nitrogen sources or...
25,195,258
[ -0.1314909, 0.07449228, 0.09979828, 0.2584147, 0.1853177, 0.1225231, -0.1491726, 0.3536398, 0.2630107, -0.3106485, -0.1250726, -0.3259136, 0.01084565, 0.4110906, -0.3835557, -0.1279017, -0.6626534, -0.02106086, -0.1652157, 0.07200115, 0.5961559, 0.2435995, -0.2733773, -...
[The expression and significance of Dickkopf-1 and GATA-6 in laryngeal carcinoma].
To investigate the expression of Dickkopf-1 and GATA-6 in laryngeal carcinoma and to discuss their relevance and the roles in carcinogenesis and development of laryngeal carcinoma. Immunohistochemical technique was used to detect the expression of Dickkopf-1 and GATA-6 protein in 48 tissues of larynge al carcinoma, 48 ...
25,195,275
[ 0.08165132, -0.3232077, -0.3222992, -0.08336567, -0.1091645, -0.3151695, 0.01157005, 0.2957485, 0.004166825, 0.06471581, 0.3186416, 0.5994431, 0.1317245, -0.3411401, -0.5997913, -0.2313599, -0.2143553, -0.008140251, 0.1375221, -0.1920537, 0.4795727, -0.03281024, -0.298539...
[Occurrence and clinical characteristics of tuberculosis among home medical care patients].
To clarify the occurrence and clinical characteristics of tuberculosis among home medical care patients, we conducted a retrospective study of patients who received home medical care from our hospital. We investigated 502 patients (mean age, 79.5 years) who received home medical care from our hospital between January 2...
25,195,299
[ -0.2957025, -0.2505448, -0.0331824, -0.01678148, -0.02968052, -0.03169704, -0.07241035, 0.01422457, -0.173943, -0.2915412, -0.1081205, -0.1157921, 0.0502557, -0.03866446, 0.0425478, -0.002148166, 0.06434154, 0.2895892, 0.00791848, -0.07652049, 0.1884827, -0.005706933, 0.0...
[Comparison of tests results between T-SPOT.TB and QuantiFERON-TB Gold In-Tube in a contact investigation].
We compared T-SPOT.TB (T-SPOT) and QuantiFERON-TB Gold In-Tube (QFT-GIT) test results in a contact investigation. The index case was a male lecturer at a vocational school in Tokyo. Chest X-ray examinations and T-SPOT tests were performed on all 397 contacts, and QFT-GIT was performed on a subset of these contact subje...
25,195,300
[ -0.1909263, 0.07062528, 0.04614662, 0.05494184, -0.06134041, -0.0578154, -0.2052395, -0.1796945, 0.1166629, -0.09062315, 0.2318852, 0.1348521, 0.02111286, 0.2193541, -0.6995696, -0.20198, -0.2268146, 0.3169017, 0.463883, 0.135954, 0.1409107, 0.2698892, 0.1135276, -0.169...
Operated bronchial carcinoids: clinical outcomes and long-term follow-up of a single institution series of 30 patients.
Bronchial carcinoids (BCs) are infrequent neoplasms that account for only 1% to 2% of all lung tumors. We reviewed the outcomes and long-term follow-up data of all patients diagnosed with BC and treated surgically at our institution between the years 2002-2009. We analyzed the records of all patients with BC treated be...
25,195,306
[ 0.1545943, -0.1443855, -0.2716403, -0.6627713, -0.2249641, -0.2100665, 0.09083883, -0.2285682, -0.1404059, 0.1644087, 0.1128145, 0.2583439, -0.03368028, -0.2051084, 0.06478221, -0.2940468, -0.02425322, 0.1894873, 0.3429474, 0.1304862, 0.4408758, 0.3935868, -0.07324243, ...
Analysis of body mass components in national club football players in Republic of Macedonia.
This study aims to analyze body composition in adult male football players and its changes during adulthood. Adult male football players (n = 942, mean age 24.11 +/- 4.69 y), all members of national competitive clubs from Macedonia were included in the study. The absolute and the relative body components were calculate...
25,195,351
[ 0.009804607, 0.4319845, 0.009726255, 0.02504959, 0.02191589, -0.2209337, -0.5121394, 0.1424647, 0.04246439, -0.2315467, -0.0124531, -0.2210816, 0.1928849, -0.2612216, -0.6256622, -0.08202968, 0.257475, 0.4387433, 0.07127763, 0.3779617, 0.4711872, -0.1417425, 0.08034552, ...
Therapeutic modalities of exudative age-related macular degeneration.
Age-related macular degeneration (AMD) is a leading cause of irreversible serious vision damage in persons over 50 years of age. In treating AMD many medicaments are applied such as inhibitors of vascular endothelial growth factor (VEGF), have been very carefully included over the last few years after a series of study...
25,195,354
[ -0.2376723, 0.09342869, -0.1539443, -0.1911902, 0.1578588, -0.1533156, 0.06698098, 0.1453557, 0.2318005, -0.1123529, 0.03144515, 0.4115301, -0.1583973, -0.141825, -0.2507875, -0.1463525, -0.3946281, 0.08384247, -0.1397188, -0.0600175, 0.1138366, 0.1396096, -0.2432164, -...
Effect of broadcast baiting on abundance patterns of red imported fire ants (Hymenoptera: Formicidae) and key local ant genera at long-term monitoring sites in Brisbane, Australia.
In 2001, the red imported fire ant (Solenopsis invicta Buren) was identified in Brisbane, Australia. An eradication program involving broadcast bait treatment with two insect growth regulators and a metabolic inhibitor began in September of that year and is currently ongoing. To gauge the impacts of these treatments on...
25,195,416
[ 0.2341677, -0.09396271, 0.007177715, -0.02074246, 0.1292523, -0.1954892, -0.225642, -0.01919102, 0.2168245, 0.1498081, -0.03154262, -0.1423828, -0.0956753, -0.06803895, -0.316898, -0.0538865, -0.3094092, 0.1569242, 0.388956, 0.09761225, -0.005638027, 0.4020737, -0.2345106...
Infectivity and transmission of Xylellua fastidiosa by Philaenus spumarius (Hemiptera: Aphrophoridae) in Apulia, Italy.
Discovery of Xylella fastidiosa from olive trees with "Olive quick decline syndrome" in October 2013 on the west coast of the Salento Peninsula prompted an immediate search for insect vectors of the bacterium. The dominant xylem-fluid feeding hemipteran collected in olive orchards during a 3-mo survey was the meadow sp...
25,195,417
[ 0.3674123, -0.1675046, -0.01003987, -0.01867756, -0.1235756, -0.1253833, -0.06142258, -0.08139318, 0.03494493, -0.2084002, 0.1807498, 0.2234372, -0.03726842, 0.06004619, -0.4874625, -0.3283142, -0.3269237, 0.2317032, 0.1065076, -0.125093, 0.4419113, 0.3158396, -0.00308846...
Seasonal migration of Apolygus lucorum (Hemiptera: Miridae) over the Bohai Sea in northern China.
During the past decade, Apolygus lucorum (Meyer-Dür) has become a key pest on cotton in northern China. Whether or not this species is a migrant, and if so, what pattern of seasonal migration this species exhibits remains unknown. The combination of searchlight trapping and radar observation on an isolated island in th...
25,195,428
[ -0.1036031, 0.1049013, 0.2035365, -0.3198844, 0.1369441, -0.3105718, -0.06325783, 0.06745585, 0.1307119, -0.02470555, 0.09604985, -0.0743667, 0.1117314, 0.004108017, -0.2792871, -0.1209231, -0.5294613, 0.2884338, 0.1840964, -0.4379588, 0.1729611, 0.3717431, -0.1433208, ...
DNA barcoding to improve the species-level management of wireworms (Coleoptera: Elateridae).
Economically important species of wireworms (Coleoptera: Elateridae) were successfully associated with adults using cytochrome oxidase I (COI) barcoding, proving the usefulness of this technique to associate life stages in taxonomically difficult pest groups. Previously unrecognized and morphologically difficult, even ...
25,195,439
[ 0.03916057, 0.3541152, 0.361624, -0.09081581, -0.03118314, -0.3173518, -0.5505257, -0.1258576, 0.2456933, 0.08651125, 0.03467424, -0.06867758, -0.04073491, 0.05906469, -0.358979, 0.1027569, -0.3901598, 0.1130097, 0.1960303, 0.01296395, 0.2630719, 0.123494, -0.2033125, 0...
High levels of resistance to carbamate and pyrethroid chemicals widespread in Australian Myzus persicae (Hemiptera: Aphididae) populations.
The green peach aphid, Myzus persicae (Sulzer), is a serious pest throughout the world, attacking a broad range of crop plants across numerous agricultural industries. This species has a high propensity to develop chemical resistance, and has the unenviable title of having resistance to more insecticides than any other...
25,195,456
[ -0.2892507, 0.2128936, 0.1762313, -0.1272734, 0.2164495, 0.1112658, -0.2607509, -0.1324507, 0.3477212, 0.03032024, 0.5261608, -0.1536012, -0.04789219, 0.2154427, 0.2328872, -0.1741628, -0.6351005, -0.01573035, 0.1126044, -0.1511866, -0.1709764, 0.3267976, -0.1284744, -0...
St. Augustine grass germplasm resistant to Blissus insularis (Hemiptera: Blissidae).
St. Augustine grass (Stenotaphrum secundatum (Walter) Kuntze) is an economically important turfgrass in the southeastern United States. However, this turf species is prone to southern chinch bug, Blissus insularis Barber (Heteroptera: Blissidae) outbreaks. This insect is the most destructive pest of St. Augustine grass...
25,195,463
[ -0.000104451, -0.19867, 0.4066748, 0.1760654, 0.07846453, -0.1074388, -0.2179891, -0.0486199, 0.6476392, -0.09751105, -0.08080252, -0.022924, 0.04386745, -0.1689259, -0.3817554, -0.5867987, -0.4217214, 0.04188268, 0.0697215, -0.2382805, -0.09939621, 0.4483413, -0.4541914,...
The 'anatomically difficult' denture case.
Complete loss of teeth from one or both arches is a disabling condition which is usually managed by a conventional removable denture. Rehabilitation may be poorly tolerated by patients, particularly in the lower jaw, and is more difficult in situations when the anatomy of the denture-bearing area is less favourable. Th...
25,195,482
[ -0.2538901, 0.311928, -0.07279177, 0.1133852, -0.009215507, -0.4535197, -0.1063196, 0.3460467, -0.2146242, 0.01927785, 0.2046814, 0.1910927, -0.1107548, -0.2191262, -0.1537838, -0.1762491, -0.0517124, -0.110905, -0.2671715, -0.3467626, 0.1098834, 0.3361966, -0.04793156, ...
Use of parent report to screen for feeding difficulties in young children.
This study aimed to collect data on Australian children with regard to feeding difficulties using a standardised questionnaire, compare these data to international data collected using the same tool, assess the short-term reliability of this tool and determine the sensitivity and specificity of this tool in detecting f...
25,195,498
[ 0.05746315, 0.05179932, -0.0003813974, -0.2152222, 0.1401106, -0.1148003, -0.1561621, 0.2332078, -0.05829057, -0.260538, 0.3706979, 0.008735338, -0.2432429, -0.2479623, -0.1644584, -0.2340542, -0.4231834, 0.4405528, -0.006354424, -0.1928006, -0.07912041, 0.04077819, 0.085...
Uhthoff's phenomenon in multiple sclerosis and neuromyelitis optica.
To evaluate and compare the incidence and clinical features of Uhthoff's phenomenon in Japanese patients with neuromyelitis optica (NMO) and those with multiple sclerosis (MS), we asked 135 consecutive patients with MS and an NMO-related disorder (NMOrd) whether they experienced worse neurological symptoms after an inc...
25,195,501
[ -0.02829917, -0.2435336, -0.1583301, -0.1235576, 0.2587452, -0.2948195, -0.2853926, -0.2324939, 0.2690406, -0.310366, 0.0972409, -0.07984581, 0.4061033, -0.5546703, 0.1801184, -0.1537581, -0.3092267, 0.169499, -0.1194692, -0.4410926, 0.3660442, 0.342422, 0.04474467, 0.1...
Quality control and infiltration of translation by amino acids outside of the genetic code.
Translation of the genome into functional proteins is critical for cellular life. Accurate protein synthesis relies on proper decoding of mRNAs by the ribosome using aminoacyl-tRNAs. During aminoacyl-tRNA synthesis, stringent substrate discrimination and rigorous product proofreading ensure tRNAs are paired with the co...
25,195,507
[ -0.04357338, 0.4035553, -0.1032824, -0.08636693, 0.04108668, -0.111186, 0.2608032, 0.2381936, 0.1935021, -0.1137329, 0.04441336, -0.1189805, 0.08266149, 0.03846188, -0.2377719, -0.06439342, -0.1500069, -0.01501709, -0.1848265, -0.006457528, 0.2705467, 0.2958226, -0.200647...
Amino acids 89-96 of Salmonella typhimurium flagellin represent the major domain responsible for TLR5-independent adjuvanticity in the humoral immune response.
Toll-like receptor 5 (TLR5) signaling in response to flagellin is dispensable for inducing humoral immunity, but alterations of aa 89-96, the TLR5 binding site, significantly reduced the adjuvanticity of flagellin. These observations indicate that the underlying mechanism remains incompletely understood. Here, we found...
25,195,514
[ -0.3154805, -0.24371, -0.1286169, -0.2088712, 0.06203442, -0.05218603, -0.1328084, 0.1271001, 0.06757624, -0.03209992, 0.27975, 0.3658066, -0.1174392, -0.1112133, 0.2099664, -0.206, -0.3372505, -0.05225283, -0.4152286, 0.483757, 0.0962235, 0.4178399, -0.2126939, -0.0972...
What is the impact of a country-wide scale-up in antiviral therapy on the characteristics and sustained viral response rates of patients treated for hepatitis C?
The global burden associated with hepatitis C virus (HCV) infection has prompted a scale-up of antiviral therapy. Hitherto, no data exist on the impact of scaling-up, on the characteristics of treated populations, or on sustained viral response (SVR) rates. We assessed the country-wide scale-up of antiviral therapy in ...
25,195,556
[ -0.1348796, 0.2177862, -0.3297563, 0.1282569, 0.2248093, -0.115902, -0.1436081, 0.0913927, 0.0339604, 0.09464046, 0.03802987, 0.01916823, 0.1287754, 0.2329732, -0.02467116, -0.2799333, 0.265756, 0.4097162, 0.2303311, 0.1490266, -0.0877983, 0.05533837, -0.08438062, 0.033...