title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Catalytic asymmetric functionalization of aromatic C-H bonds by electrophilic trapping of metal-carbene-induced zwitterionic intermediates. | Asymmetric functionalization of aromatic C-H bonds of N,N-disubstituted anilines with diazo compounds and imines is reported for the efficient construction of α,α-diaryl benzylic quaternary stereocenters in good yields with high diastereoselectivities and excellent enantioselectivities. This Rh(II)/chiral phosphoric ac... | 25,195,569 | [
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Renal parenchymal histopathology predicts life-threatening chronic kidney disease as a result of radical nephrectomy. | The preoperative prediction of post-radical nephrectomy renal insufficiency plays an important role in the decision-making process regarding renal surgery options. Furthermore, the prediction of both postoperative renal insufficiency and postoperative cardiovascular disease occurrence, which is suggested to be an adver... | 25,195,572 | [
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Stereoscopic visualization and quantification of auricular cartilage regeneration in rabbits using multiphoton microscopy. | Multiphoton microscopy (MPM) was applied for imaging and quantifying the elastic cartilage regeneration tissue in a rabbit ear model without using labeling agents. Morphology of cells and collagen matrix were analysis, showing significant difference between regenerated and intact cartilage in cellular size and collagen... | 25,195,587 | [
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Polymer sieving matrices in microanalytical electrophoresis. | Microfluidic design has advanced existing protein separation capabilities and supported novel assays. Key metrics for successful protein separations include fast, robust, and sensitive analysis of complex mixtures of bio-macromolecules. Attaining high separation resolution is a chief concern. Here we review recent adva... | 25,195,612 | [
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Facile synthesis of one-dimensional Mn₃O₄/Zn₂SnO₄ hybrid composites and their high performance as anodes for LIBs. | One-dimensional (1D) Mn₃O₄ nanorod/Zn2SnO4 nanoneedle hierarchical composites were conveniently synthesized via a simple hydrothermal process at 180 °C for 24 h. It was found that the reaction time and an appropriate amount of ammonia play vital roles during their formation process, and their formation is likely driven... | 25,195,654 | [
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Synthesis of Pt-Ni alloy nanocrystals with high-index facets and enhanced electrocatalytic properties. | The shape-controlled synthesis of multicomponent metal nanocrystals (NCs) bounded by high-index facets (HIFs) is of significant importance in the design and synthesis of high-activity catalysts. We report herein the preparation of Pt-Ni alloy NCs by tuning their shape from concave-nanocubic (CNC) to nanocubic and hexoc... | 25,195,668 | [
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Curcumin inhibits the proliferation and invasiveness of MHCC97-H cells via p38 signaling pathway. | Curcumin has been reported to be effective as a cancer therapy. However, the anti-metastatic effect and molecular mechanism(s) of curcumin in hepatocellular carcinoma (HCC) remain poorly understood. The purpose of this study was to test the effects of curcumin on HCC and its putative mechanism(s). Curcumin inhibited th... | 25,195,681 | [
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Coeliac-like duodenal pathology in orthotopic liver transplant patients on mycophenolic acid therapy. | Diarrhoea following orthotopic liver transplantation (OLT) is a significant clinical problem associated with mycophenolic acid (MPA). The histological injury pattern associated with MPA in the large bowel is well documented in the literature; however, that in the duodenum is less extensively documented. The aim of this... | 25,195,696 | [
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Synaptic Pathophysiology and Treatment of Lambert-Eaton Myasthenic Syndrome. | Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disease that disrupts the normally reliable neurotransmission at the neuromuscular junction (NMJ). This disruption is thought to result from an autoantibody-mediated removal of a subset of the P/Q-type Ca(2+) channels involved with neurotransmitter release. With... | 25,195,700 | [
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Effects of green tea and physical exercise on memory impairments associated with aging. | We investigated the effects of physical exercise and green tea supplementation (associated or not) on biochemical and behavioral parameters in the time course of normal aging. Male Wistar rats aged 9 months were divided into groups: control, physical exercise (treadmill running), and supplemented with green tea while e... | 25,195,719 | [
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Measurement and the interpretation of burden in the Alzheimer's disease experience. | Three components of the Alzheimer's disease care equation are considered : impairment, felt burden, and the institutionalization decision. Measurement and the results of existing studies are compared with field data on the descriptive organization of the caregiving experience. It is suggested that measurement is an ina... | 25,195,724 | [
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Virulence and genotypic characterization of Listeria monocytogenes isolated from vegetable and soil samples. | Listeria monocytogenes, a foodborne pathogen is ubiquitous to different environments including the agroecosystem. The organism poses serious public health problem. Therefore, an attempt has been made to gain further insight to their antibiotic susceptibility, serotypes and the virulence genes. Out of the 10 vegetables ... | 25,195,727 | [
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Priming IKKβ kinase for action. | IKKβ (IκB kinase β) is a core component of signalling pathways that control the activation of NF-κB (nuclear factor κB) transcription factors, which regulate many physiological processes, including cell survival, immunity and DNA-damage responses. Like many kinases, activation of IKKβ requires phosphorylation of the ac... | 25,195,736 | [
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Satellite tobacco mosaic virus refined to 1.4 Å resolution. | Satellite tobacco mosaic virus (STMV) is among the smallest viruses, having 60 identical subunits arranged with T = 1 icosahedral symmetry. Its crystal structure was solved at 290 K and was refined using, in part, crystals grown in microgravity. Electron-density maps revealed nearly 57% of the genomic ssRNA. Using six ... | 25,195,746 | [
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Space-group and origin ambiguity in macromolecular structures with pseudo-symmetry and its treatment with the program Zanuda. | The presence of pseudo-symmetry in a macromolecular crystal and its interplay with twinning may lead to an incorrect space-group (SG) assignment. Moreover, if the pseudo-symmetry is very close to an exact crystallographic symmetry, the structure can be solved and partially refined in the wrong SG. Typically, in such in... | 25,195,756 | [
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Post-traumatic stress disorder among Syrian refugees in Turkey: a cross-sectional study. | Refugees have had major challenges to meet their health care needs throughout history especially in war zones and natural disaster times. The health care needs of Syrian refugees have been becoming an increasingly important issue. We aimed to examine the prevalence of post-traumatic stress disorder (PTSD) and explore i... | 25,195,765 | [
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T cell-based targeted immunotherapies for patients with multiple myeloma. | Despite high-dose chemotherapy followed by autologs stem-cell transplantation as well as novel therapeutic agents, multiple myeloma (MM) remains incurable. Following the general trend towards personalized therapy, targeted immunotherapy as a new approach in the therapy of MM has emerged. Better progression-free surviva... | 25,195,787 | [
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Stimulus-responsive ultrasound contrast agents for clinical imaging: motivations, demonstrations, and future directions. | Microbubble ultrasound contrast agents allow imaging of the vasculature with excellent resolution and signal-to-noise ratios. Contrast in microbubbles derives from their interaction with an ultrasound wave to generate signal at harmonic frequencies of the stimulating pulse; subtracting the elastic echo caused by the su... | 25,195,785 | [
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Microbial community composition and in silico predicted metabolic potential reflect biogeochemical gradients between distinct peatland types. | It is not well understood how the ecological status and microbial community composition of spruce swamp forests (SSF) relate to those found in bogs and fens. To clarify this, we investigated biogeochemical parameters and microbial community composition in a bog, a fen and two SSF using high throughput barcoded sequenci... | 25,195,805 | [
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The hexosamine biosynthetic pathway induces gene promoter activity of acetyl-CoA carboxylase beta. | The cardiac isoform of acetyl-CoA carboxylase (ACCβ) produces malonyl-CoA, a potent inhibitor of mitochondrial fatty acid (FA) uptake. Higher ACCβ activity decreases FA utilization, potentially leading to intracellular myocardial lipid accumulation and insulin resistance (IR). Since increased hexosamine biosynthetic pa... | 25,195,817 | [
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Ceramide modulates pre-mRNA splicing to restore the expression of wild-type tumor suppressor p53 in deletion-mutant cancer cells. | Mutants of tumor suppressor p53 not only lose the activity in genome stabilizing and in tumor suppression, but also exhibit oncogenic function in cancer cells. Most efforts in restoring p53 biological activity focus on either altering mutant-protein conformation or introducing an exogenous p53 gene into cells to elimin... | 25,195,822 | [
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Support for aging policy: Self-interest, social justice, and political symbols. | This article explores and evaluates theoretical assumptions implied by the familiar hypothesis that anti-elderly scapegoating rhetoric is producing attitude change with respect to citizen support for aging policy. An explanation-the self-interest model-that is consistent with both this hypothesis and existing attitude ... | 25,195,846 | [
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Optimization of a cell counting algorithm for mobile point-of-care testing platforms. | In a point-of-care (POC) setting, it is critically important to reliably count the number of specific cells in a blood sample. Software-based cell counting, which is far faster than manual counting, while much cheaper than hardware-based counting, has emerged as an attractive solution potentially applicable to mobile P... | 25,195,851 | [
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Particle swarm inspired underwater sensor self-deployment. | Underwater sensor networks (UWSNs) can be applied in sea resource reconnaissance, pollution monitoring and assistant navigation, etc., and have become a hot research field in wireless sensor networks. In open and complicated underwater environments, targets (events) tend to be highly dynamic and uncertain. It is import... | 25,195,852 | [
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Prevalence and cost of epilepsy in Sweden--a register-based approach. | To estimate the prevalence of epilepsy, costs associated with in- and outpatient care, drug utilization and productivity losses due to epilepsy in Sweden for the years 2005 and 2011. Cost components were calculated using registry data on inpatient- and outpatient-care utilization, drug sales and early pensions granted ... | 25,195,857 | [
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The role of pericyte detachment in vascular rarefaction. | Pericytes surround endothelial cells at the perivascular interface. Signaling between endothelial cells and pericytes is crucial for capillary homeostasis, as pericytes stabilize vessels and regulate many microvascular functions. Recently it has been shown that pericytes are able to detach from the vascular wall and co... | 25,195,856 | [
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Controlling sulphur precursor addition for large single crystal domains of WS2. | We show that controlling the introduction time and the amount of sulphur (S) vapour relative to the WO3 precursor during the chemical vapour deposition (CVD) growth of WS2 is critical to achieving large crystal domains on the surface of silicon wafers with a 300 nm oxide layer. We use a two furnace system that enables ... | 25,195,869 | [
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High-resolution crystal structures of alternate forms of the human CD44 hyaluronan-binding domain reveal a site for protein interaction. | Two new crystal structures of the extracellular hyaluronan-binding domain of human CD44 are described at high resolution. A hexagonal crystal form at 1.60 Å resolution and a monoclinic form at 1.08 Å resolution both have two molecules in the asymmetric unit arranged about a similar noncrystallographic twofold axis of s... | 25,195,884 | [
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Crystallization and preliminary X-ray diffraction analysis of the periplasmic domain of the Escherichia coli aspartate receptor Tar and its complex with aspartate. | The cell-surface receptor Tar mediates bacterial chemotaxis toward an attractant, aspartate (Asp), and away from a repellent, Ni(2+). To understand the molecular mechanisms underlying the induction of Tar activity by its ligands, the Escherichia coli Tar periplasmic domain with and without bound aspartate (Asp-Tar and ... | 25,195,895 | [
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The mediating effect of prefrontal asymmetry on the relationship between the COMT Val(158)Met SNP and trait consummatory positive affect. | The Val(158)Met rs4680 polymorphism in the COMT gene regulates dopamine catabolism in the prefrontal cortex (PFC). Dopamine's involvement in reward experience suggests those with the methionine (Met) variant may exhibit trait-level sensitivity to reward due to more post-synaptic dopamine in the PFC. A physiological med... | 25,195,915 | [
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A sleep bruxism detection system based on sensors in a splint - pilot clinical data. | It is difficult in a dental setting to accurately diagnose sleep bruxism and to objectively assess the severity, frequency or natural history of the condition in an individual patient. Yet this information is essential for the management of sleep bruxism and to plan appropriate dental treatment. The objective of this s... | 25,195,920 | [
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Averaging techniques for reaction barriers in QM/MM simulations. | Herein, we test and compare different techniques to obtain averaged reaction barriers from quantum mechanics/molecular mechanics (QM/MM) simulations based on snapshots taken from molecular dynamics. Reasonable values can be obtained from a fairly small sample of well-chosen snapshots if an exponential averaging, also c... | 25,195,924 | [
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Self-replication and amplification of enantiomeric excess of chiral multifunctionalized large molecules by asymmetric autocatalysis. | Self-replication of large chiral molecular architectures is one of the great challenges and interests in synthetic, systems, and prebiotic chemistry. Described herein is a new chemical system in which large chiral multifunctionalized molecules possess asymmetric autocatalytic self-replicating and self-improving abiliti... | 25,195,925 | [
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Examining convergence of retrospective and ecological momentary assessment measures of negative affect and eating disorder behaviors. | Data gathered via retrospective forms of assessment are subject to various recall biases. Ecological momentary assessment (EMA) is an alternative approach involving repeated momentary assessments within a participant's natural environment, thus reducing recall biases and improving ecological validity. EMA has been used... | 25,195,932 | [
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Psychotropic drugs and bruxism. | Sleep and awake bruxism is defined as 'a parafunctional activity including clenching, bracing, gnashing, and grinding of the teeth'. Some evidence suggests that bruxism may be caused by, or associated with, alterations in the CNS neurotransmission. Several classes of psychotropic drugs interfering with CNS activity may... | 25,195,948 | [
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Adherence to insulin treatment in diabetes: can it be improved? | Insulin is used in all subjects with Type 1 diabetes, and when Type 2 diabetes is not controlled by oral anti-diabetic medicines, insulin is also used in Type 2 diabetes. However, despite this use, there is still increased mortality and morbidity in subjects with diabetes, compared to subjects without diabetes. One of ... | 25,195,971 | [
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Maintenance of bowel, bladder, and motor functions after sacrectomy. | Repeated cohort studies have consistently demonstrated a survival advantage after en bloc resection for locally aggressive primary tumors in the sacrum. A sacrectomy is often required to remove the tumor en bloc, which may necessitate the sacrifice of sacral nerves. This can potentially result in functional complicatio... | 25,195,977 | [
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Age disparity in palliative radiation therapy among patients with advanced cancer. | Palliative radiation therapy represents an important treatment option among patients with advanced cancer, although research shows decreased use among older patients. This study evaluated age-related patterns of palliative radiation use among an elderly Medicare population. We identified 63,221 patients with metastatic... | 25,195,994 | [
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The rhetoric of racism: revisiting the creation of the Psychological Institute of the Republic of South Africa (1956-1962). | This paper revisits the 1962 splitting of the South African Psychological Association (SAPA), when disaffected Afrikaner psychologists broke away to form the whites-only Psychological Institute of the Republic of South Africa (PIRSA). It presents an analysis of the rhetorical justification for forming a new professiona... | 25,196,057 | [
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EpsinR, a target for pyrenocine B, role in endogenous MHC-II-restricted antigen presentation. | While the presentation mechanism of antigenic peptides derived from exogenous proteins by MHC class II molecules is well understood, relatively little is known about the presentation mechanism of endogenous MHC class II-restricted antigens. We therefore screened a chemical library of 200 compounds derived from natural ... | 25,196,058 | [
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Determining the major Bt refuge crops for cotton bollworm in North China. | Evaluation of the effectiveness of refuge strategies involved in cotton bollworm Bt resistance management would be aided by technologies that allow monitoring and quantification of key factors that affect the process under field conditions. We hypothesized that characterization of stable carbon and nitrogen isotopes in... | 25,196,072 | [
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0.065298... |
Spectroscopic signatures for interlayer coupling in MoS2-WSe2 van der Waals stacking. | Stacking of MoS2 and WSe2 monolayers is conducted by transferring triangular MoS2 monolayers on top of WSe2 monolayers, all grown by chemical vapor deposition (CVD). Raman spectroscopy and photoluminescence (PL) studies reveal that these mechanically stacked monolayers are not closely coupled, but after a thermal treat... | 25,196,077 | [
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Hydrogen sulfide acts as a pro-inflammatory mediator in rheumatic disease. | Hydrogen sulfide (H<sub2</sub S) is a gaseous mediator produced in the body. In experimental models, endogenously produced H<sub2</sub S has been shown to have pro-inflammatory effects. The aim of this study was to investigate whether H<sub2</sub S is present in three common rheumatic diseases, rheumatoid arthritis (RA... | 25,196,086 | [
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Tenascin-C is required for normal Wnt/β-catenin signaling in the whisker follicle stem cell niche. | Whisker follicles have multiple stem cell niches, including epidermal stem cells in the bulge as well as neural crest-derived stem cells and mast cell progenitors in the trabecular region. The neural crest-derived stem cells are a pool of melanocyte precursors. Previously, we found that the extracellular matrix glycopr... | 25,196,097 | [
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Montelukast-induced adverse drug reactions: a review of case reports in the literature. | Montelukast, a leucotriene receptor antagonist, binds the cysteinyl leucotriene type 1 receptor. Montelukast is commonly prescribed to asthma patients as add-on therapy to inhaled corticosteroids. Several clinical trials emphasized that montelukast can be considered a safe drug. However, recent evidence reconsidered th... | 25,196,099 | [
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Automated detection and recognition of wildlife using thermal cameras. | In agricultural mowing operations, thousands of animals are injured or killed each year, due to the increased working widths and speeds of agricultural machinery. Detection and recognition of wildlife within the agricultural fields is important to reduce wildlife mortality and, thereby, promote wildlife-friendly farmin... | 25,196,105 | [
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Open reduction and internal fixation of extracapsular mandibular condyle fractures: a long-term clinical and radiological follow-up of 25 patients. | During the last 2 decades, many studies on the treatment of mandibular condyle fracture have been published. The incidence of mandibular condyle fractures is variable, ranging from 17.5% to 52% of all mandibular fractures. This retrospective study evaluated the long-term clinical and radiological outcomes after surgica... | 25,196,114 | [
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Extension and validation of the GROMOS 53A6(GLYC) parameter set for glycoproteins. | An extension of the GROMOS 53A6GLYC force field for carbohydrates to encompass glycoprotein linkages is presented. The set includes new atomic charges and incorporates adequate torsional potential parameters for N-, S-, C-, P-, and O-glycosydic linkages, offering compatibility with the GROMOS force field family for pro... | 25,196,137 | [
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Long-term type 1 diabetes alters the deposition of collagens and proteoglycans in the early pregnant myometrium of mice. | We have previously shown that long-term type 1 diabetes affects the structural organization, contractile apparatus and extracellular matrix (ECM) of the myometrium during early pregnancy in mice. This study aimed to identify which myometrial ECM components are affected by diabetes, including fibril-forming collagen typ... | 25,196,145 | [
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Redox interactions between Cr(VI) and Fe(II) in bioreduced biotite and chlorite. | Contamination of the environment with Cr as chromate (Cr(VI)) from industrial activities is of significant concern as Cr(VI) is a known carcinogen, and is mobile in the subsurface. The capacity of Fe(II)-containing phyllosilicates including biotite and chlorite to alter the speciation, and thus the mobility, of redox-s... | 25,196,156 | [
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0.02543... |
Effectiveness of a television advertisement campaign on giving cigarettes in a chinese population. | Anti-tobacco television advertisement campaigns may convey messages on smoking-related health consequences and create norms against giving cigarettes. Altogether, 156 and 112 slots of a television advertisement "Giving cigarettes is giving harm" were aired on Suzhou and Yizheng, respectively, over one month in 2010. Pa... | 25,196,169 | [
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Shifting chemical equilibria in flow--efficient decarbonylation driven by annular flow regimes. | To efficiently drive chemical reactions, it is often necessary to influence an equilibrium by removing one or more components from the reaction space. Such manipulation is straightforward in open systems, for example, by distillation of a volatile product from the reaction mixture. Herein we describe a unique high-temp... | 25,196,172 | [
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In vitro and in vivo evaluations of three-dimensional hydroxyapatite/silk fibroin nanocomposite scaffolds. | In this study, three-dimensional hydroxyapatite/silk fibroin (HAp/SF) nanocomposite scaffolds were successfully prepared through layer solvent casting combined with the freeze-drying technique for tissue engineering applications. Various SF aqueous concentrations, ranging from 2.5% to 10%, were used to control the phys... | 25,196,187 | [
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0... |
Quality of life in non-melanoma skin cancer. | Basal cell carcinoma and squamous cell carcinoma are the most common malignancies and are classified under the umbrella of non-melanoma skin cancer (NMSC). NMSC exerts a small but appreciable decrement in quality of life (QOL). The impact posed may arise from the tumour itself or as a result of treatment, and through s... | 25,196,191 | [
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Caregivers of Children with Congenital Heart Disease: Does Socioeconomic Class Have Any Effect on Their Perceptions? | Studies from other parts of the world have documented knowledge gaps in parents of children with congenital heart disease (CHD). The authors are not aware of any study in the Nigerian population assessing the effect of socioeconomic class on the perceptions of caregivers of children with CHD. The study aimed to evaluat... | 25,196,209 | [
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A straightforward approach towards cyclic photoactivatable tubulysin derivatives. | The development of a new photolabile protecting group containing an additional allyl functionality allows the synthesis of cyclic photoactivatable natural products. Cyclization occurs between the allyl moiety in the protecting group and a second double bond in the target molecule by means of ring-closing metathesis. Cy... | 25,196,233 | [
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Changes in secondary organic aerosol composition and mass due to photolysis: relative humidity dependence. | This study is focused on the relative humidity (RH) dependence of water-soluble secondary organic aerosol (SOA) aging by photolysis. Particles containing α-pinene SOA and ammonium sulfate, generated by atomization, were exposed to UV radiation in an environmental chamber at three RH conditions (5, 45, and 85%), and cha... | 25,196,234 | [
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Global health and development in early childhood. | Health and nutritional risks co-occur in the lives of children under the age of 2 years who live in developing countries. We review evidence showing how these risks, in addition to inadequate psychosocial stimulation, prevent children from developing expected cognitive and language abilities. A systematic review and me... | 25,196,276 | [
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Regional comparisons of porcine menisci. | The purpose of this study was to analyze histologic, biochemical, and biomechanical differences between zonal, regional, and anatomic locations of porcine menisci. We evaluated six menisci removed from pigs. Medial and lateral menisci were divided into three regions: anterior, middle, and posterior. In each portion, th... | 25,196,310 | [
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Water-splitting electrocatalysis in acid conditions using ruthenate-iridate pyrochlores. | The pyrochlore solid solution (Na(0.33)Ce(0.67))2(Ir(1-x)Ru(x))2O7 (0≤x≤1), containing B-site Ru(IV) and Ir(IV) is prepared by hydrothermal synthesis and used as a catalyst layer for electrochemical oxygen evolution from water at pH<7. The materials have atomically mixed Ru and Ir and their nanocrystalline form allo... | 25,196,322 | [
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Changing tracks as situations change: humanitarian and health response along the Liberia-Côte d'Ivoire border. | In recent years, protracted crises and fragile post-conflict settings have challenged the co-existence, and even the linear continuum, of relief and development aid. Forced migration has tested humanitarian and development paradigms where sudden-onset emergencies, violence and displacement arise alongside ongoing devel... | 25,196,331 | [
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The self-built ecovillage in L'Aquila, Italy: community resilience as a grassroots response to environmental shock. | The paper applies the community resilience approach to the post-disaster case of Pescomaggiore, an Italian village affected by the L'Aquila earthquake in 2009. A group of residents refused to accept the housing recovery solutions proposed by the government, opting for autonomous recovery. They developed a housing proje... | 25,196,333 | [
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Improved Thin-Film Transistor Performance Through a Melt of Poly(para-phenyleneethynylene). | The performance of polymer field-effect transistors (PFETs) based on short rigid rod semiconducting poly(2,5-didodecyloxy-p-phenyleneethynylene) (D-OPPE) is highlighted. The controlled heating and cooling of thin films of D-OPPE allows for a recrystallization from the melt, boosting the performance of D-OPPE-based tran... | 25,196,352 | [
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Heterozygous DLX5 nonsense mutation associated with isolated split-hand/foot malformation with reduced penetrance and variable expressivity in two unrelated families. | Split-hand/foot malformation (SHFM) is a clinically and genetically heterogeneous limb abnormality characterized by the absence or hypoplasia of the central rays of the autopod. SHFM1, which is one out of seven known SHFM loci, maps to 7q21.2-q21.3. SHFM1 is usually inherited as an autosomal dominant trait with reduced... | 25,196,357 | [
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Challenges in mucosal HIV vaccine development: lessons from non-human primate models. | An efficacious HIV vaccine is urgently needed to curb the AIDS pandemic. The modest protection elicited in the phase III clinical vaccine trial in Thailand provided hope that this goal might be achieved. However, new approaches are necessary for further advances. As HIV is transmitted primarily across mucosal surfaces,... | 25,196,380 | [
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The use of propranolol in the treatment of infantile haemangiomas: an update on potential mechanisms of action. | Currently, propranolol is the preferred treatment for problematic proliferating infantile haemangiomas (IHs). The rapid action of propranolol has been shown to be especially dramatic in IHs involving dyspnoea, haemodynamic compromise, palpebral occlusion or ulceration. Another remarkable aspect of propranolol treatment... | 25,196,392 | [
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Introduction to the special issue on achieving healthy weight in black American communities. | The prevalence of obesity is high in the United States, and highest among racial and ethnic minority groups. This special issue of Obesity Reviews is based upon evidence reviews prepared for and presented at a national invited workshop convened by the African American Collaborative Obesity Research Network (AACORN) in ... | 25,196,403 | [
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Potential roles of placental human beta-defensin-3 and apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3G in prevention of intrauterine transmission of hepatitis B virus. | Approximately 5% of newborns were infected by hepatitis B virus (HBV) via intrauterine transmission and this is the main reason for high prevalence of HBV in endemic regions. However, the mechanisms by which intrauterine transmission is avoided in most cases remain elusive and placental natural anti-microbial factors m... | 25,196,417 | [
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Priorities in the communication needs of adolescents with psychosocial problems and their parents. | In patient-centred care, professionals should recognize their patient's needs and adapt their communication accordingly. Studies into patients' communication needs suggest priorities vary depending on sociodemographic characteristics, and type and severity of the complaints. However, evidence lacks on priorities in the... | 25,196,418 | [
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A critique of a World Health Organization-commissioned report and associated paper on electronic cigarettes. | The World Health Organization (WHO) recently commissioned a report reviewing evidence on electronic cigarettes and making policy recommendations. A version of it was subsequently published as an academic paper. We identify important errors in the description and interpretation of the studies reviewed, and find many of ... | 25,196,419 | [
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Functional nanovalves on protein-coated nanoparticles for in vitro and in vivo controlled drug delivery. | A multifunctional mesoporous drug delivery system that contains fluorescent imaging molecules, targeting proteins, and pH-sensitive nanovalves is developed and tested. Three nanovalve-mesoporous silica nanoparticle (NV-MSN) systems with varied quantities of nanovalves on the surface are synthesized. These systems are c... | 25,196,485 | [
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Qualitative and quantitative analysis of fibrosis in the kidney. | Renal fibrosis results from an excess accumulation of connective tissue, primarily collagen, in response to tissue injury-associated aberrant wound healing, which is over-expressed in the renal vascular, glomerular and tubulointerstitial compartments. Despite being the final common pathway of end stage kidney disease, ... | 25,196,487 | [
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Influence of smoking dosage and chronic obstructive lung disease on the incidence of appropriate therapies and mortality in patients with structural heart disease and an implantable cardioverter defibrillator. | Smoking is known as a relevant risk factor for severe cardiac morbidities and mortality. This study was initiated to explore the influence of smoking dosage and presence of chronic obstructive lung disease (COPD) on the incidence of appropriate implantable cardioverter defibrillator (ICD) interventions and on mortality... | 25,196,490 | [
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Metal coordination, and metal-ligand redox non-innocence, modulates allosteric C-N bond homolysis in an N-benzyl tetrazine. | Remote coordination of a Ru(hfac)2 moiety to a chelating N-benzyl tetrazine lowers the C-N homolytic bond dissociation enthalpy by approximately 20 kJ mol(-1). The significant bond strength perturbation is believed to arise as a consequence of metal-ligand redox non-innocence. | 25,196,495 | [
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Bone marrow-derived progenitor cells attenuate inflammation in lipopolysaccharide-induced acute respiratory distress syndrome. | Acute respiratory distress syndrome (ARDS) is the most common cause of respiratory failure among critically ill patients. Novel treatment strategies are required to address this common clinical problem. The application of exogenous adult stem cells was associated with a beneficial outcome in various pre-clinical models... | 25,196,505 | [
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Single nucleotide polymorphisms generated by genotyping by sequencing to characterize genome-wide diversity, linkage disequilibrium, and selective sweeps in cultivated watermelon. | A large single nucleotide polymorphism (SNP) dataset was used to analyze genome-wide diversity in a diverse collection of watermelon cultivars representing globally cultivated, watermelon genetic diversity. The marker density required for conducting successful association mapping depends on the extent of linkage disequ... | 25,196,513 | [
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Complete proteome of a quinolone-resistant Salmonella Typhimurium phage type DT104B clinical strain. | Salmonellosis is one of the most common and widely distributed foodborne diseases. The emergence of Salmonella strains that are resistant to a variety of antimicrobials is a serious global public health concern. Salmonella enterica serovar Typhimurium definitive phage type 104 (DT104) is one of these emerging epidemic ... | 25,196,519 | [
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Recent approaches in vaccine development against Streptococcus pneumoniae. | Streptococcus pneumoniae is a major cause of morbidity and mortality among children under 5 years of age worldwide. Vaccines have long been used for protection against pneumococcal infections. Capsular polysaccharides of pneumococci are main antigenic components of these vaccines. However, pneumococcal polysaccharide-b... | 25,196,525 | [
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Chronic abdominal pain in a patient with escobar syndrome. | Escobar syndrome is characterized with multiple pterygia or webs of the skin and multiple congenital anomalies. We present a 15-year-old patient with Escobar syndrome who complained of persistent blunt abdominal pain for 1 year. Preoperative evaluation confirmed the diagnosis of imperforate hymen, and the patient under... | 25,196,531 | [
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Using Web searches to track interest in synthetic cannabinoids (a/k/a 'herbal incense'). | This article reports a content analysis of Internet websites related to an emerging designer drug, synthetic cannabinoids. The number of synthetic cannabinoids searchers in the USA has steadily increased from November 2008 to November 2011. To determine the information available on the Internet in relation to synthetic... | 25,196,534 | [
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The strength of aversive and appetitive associations and maladaptive behaviors. | Certain maladaptive behaviors are thought to be acquired through classical Pavlovian conditioning. Exaggerated fear response, which can develop through Pavlovian conditioning, is associated with acquired anxiety disorders such as post-traumatic stress disorders (PTSDs). Inflated reward-seeking behavior, which develops ... | 25,196,552 | [
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The case for treating refractory congestive heart failure with ultrafiltration. | Extracellular fluid retention and congestion is a fundamental manifestation of heart failure (HF) and cardiorenal syndrome (CRS). Patients are normally hospitalized and treated with diuretics, but their outcomes are often poor as severe congestion and diuretics resistance is the primary cause of HF-related hospital adm... | 25,196,568 | [
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Water-soluble manganese inorganic polymers: the role of carborane clusters and producing large structural adjustments from minor molecular changes. | The reaction of two different carboranylcarboxylate ligands, 1-CH3-2-CO2H-1,2-closo-C2B10H10 or 1-CO2H-1,2-closo-C2B10H11, with MnCO3 in water leads to polymeric compounds 1 a and 1 b. Both compounds have been characterized by analytical and spectroscopic techniques. Additionally, electrochemical techniques have also b... | 25,196,570 | [
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0.2534313,
0.1613151,
0.2558602,
0.3643371,
0.1766356,
-0.1473596,
-0.... |
A highly sensitive ratiometric fluorescent probe for the detection of cytoplasmic and nuclear hydrogen peroxide. | As a marker for oxidative stress and a second messenger in signal transduction, hydrogen peroxide (H2O2) plays an important role in living systems. It is thus critical to monitor the changes in H2O2 in cells and tissues. Here, we developed a highly sensitive and versatile ratiometric H2O2 fluorescent probe (NP1) based ... | 25,196,578 | [
0.05505142,
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0.01078616,
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0.2967132,
0.3218777,
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A long non-coding RNA, GAS5, plays a critical role in the regulation of miR-21 during osteoarthritis. | Growth Arrest-Specific 5 (GAS5) is known to negatively regulate cell survival and is aberrantly expressed in several cancers. The influence of GAS5 on osteoarthritis (OA) has not been determined. To address this, articular chondrocytes were isolated from relatively normal (Non-OA) and clear OA regions (OA) of cartilage... | 25,196,583 | [
-0.2479375,
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0.4304407,
0.0124062,
0.05903998,
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Olfactory neuroblastoma and olfactory ventricle. A case report. | A case of dumbbell nasal and intracerebral olfactory neuroblastoma (ONB) related to possible seeding through an "olfactory ventricle" in the olfactory bulb and nerve is reported. This anatomic variant was recognized at operation for the first time: it consists of a hollow cavity within the olfactory bulb and nerve whic... | 25,196,619 | [
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Isolated contralateral sudden sensorineural hearing loss: an unusual manifestation of pontine infarct. | Unilateral, acute onset sensorineural hearing loss ("sudden sensorineural hearing loss" [SSNHL]) as an isolated event without other associated neurological deficits usually results from a lesion of the cochlea. Lesions in the ascending central auditory pathways cranial to the cochlear nucleus seldom result in unilatera... | 25,196,624 | [
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0.1579036,
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Is It All about the Higher Dose? Why Psychoanalytic Therapy Is an Effective Treatment for Major Depression. | Empirical evidence for the effectiveness of long-term psychodynamic psychotherapy (LTPP) in patients with mood disorders is growing. However, it is unclear whether the effectiveness of LTPP is due to distinctive features of psychodynamic/psychoanalytic techniques or to a higher number of sessions. We tested these rival... | 25,196,642 | [
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0.06014679,
0.0115255... |
Soft magnets from the self-organization of magnetic nanoparticles in twisted liquid crystals. | Organizing magnetic nanoparticles into long-range and dynamic assemblies would not only provide new insights into physical phenomena but also open opportunities for a wide spectrum of applications. In particular, a major challenge consists of the development of nanoparticle-based materials for which the remnant magneti... | 25,196,652 | [
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Measurement of oxidative damage to DNA in nanomaterial exposed cells and animals. | Increased levels of oxidatively damaged DNA have been documented in studies of metal, metal oxide, carbon-based and ceramic engineered nanomaterials (ENMs). In particular, 8-oxo-7,8-dihydroguanine-2'-deoxyguanosine (8-oxodG) is widely assessed as a DNA nucleobase oxidation product, measured by chromatographic assays, a... | 25,196,723 | [
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... |
Oxidation of bioethanol using zeolite-encapsulated gold nanoparticles. | With the ongoing developments in biomass conversion, the oxidation of bioethanol to acetaldehyde may become a favorable and green alternative to the preparation from ethylene. Here, a simple and effective method to encapsulate gold nanoparticles in zeolite silicalite-1 is reported and their high activity and selectivit... | 25,196,739 | [
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0.2037512,
0.216804,
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0.4224953,
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Photo-Wolff Rearrangement of 2-Diazo-1,2-naphthoquinone: Stern-Volmer Analysis of the Stepwise Reaction Pathway. | 2-Diazo-1,2-naphthoquinone (1) and its derivatives are the photoactive components in Novolak photoresists. A femtosecond infrared study has established that the photoreaction of 1 proceeds largely by a concerted Wolff rearrangement yielding the ketene 1H-inden-1-ylidene-methanone (3) within 300 fs after excitation, but... | 25,196,741 | [
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0.456054,
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Physician-reported barriers to referring cancer patients to specialists: prevalence, factors, and association with career satisfaction. | Quality care for patients with cancer often requires access to specialty providers, but little is known about barriers to referring cancer patients for specialized care. Referral barriers may also lessen physician career satisfaction. The study was aimed at determining what factors are associated with these barriers an... | 25,196,776 | [
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Does exercise habit strength moderate the relationship between emotional distress and short-term memory in Malaysian primary school children? | We examined the moderating effects of exercise habit strength on the relationship between emotional distress and short-term memory in primary school children. The sample consisted of 165 primary school students (10-12 years old). Participants completed measures of emotional distress, exercise habit strength, and the Di... | 25,196,807 | [
0.2165941,
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0.4697491,
0.00176003,
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0.01365356,
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Regulatory Fe(II/III) heme: the reconstruction of a molecule's biography. | More than 20 years of research on heme as a temporary effector molecule of proteins have revealed its widespread impact on virtually all primary functions in the human organism. As our understanding of this influence is still growing, a comprehensive overview of compiled data will give fresh impetus for creativity and ... | 25,196,849 | [
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Predictive factors for severe and febrile neutropenia during docetaxel chemotherapy for castration-resistant prostate cancer. | The aim of this study is to identify factors that increase the occurrence of severe neutropenia (SN) and febrile neutropenia (FN) during docetaxel treatment for castration-resistant prostate cancer (CRPC). We retrospectively reviewed 258 courses during the first three cycles among 95 patients. Docetaxel at a dose of 75... | 25,196,861 | [
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0.1351152,
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Accompanying artery of sciatic nerve as recipient vessel for free-flap transfer: a computed tomographic angiography study and case reports. | Suitable recipient vessels for free-flap transfer are hard to find in the posterior thigh. To investigate the versatility of accompanying artery of sciatic nerve as a recipient vessel in this region, we performed computed tomographic angiographic study of 20 consecutive healthy thighs in 10 patients. The presence and i... | 25,196,891 | [
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0.293725,
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Development of a two-step high-resolution melting (HRM) analysis for screening sequence variants associated with resistance to the QoIs, benzimidazoles and dicarboximides in airborne inoculum of Botrytis cinerea. | A rapid, high-resolution melting (HRM) analysis protocol was developed to detect sequence variations associated with resistance to the QoIs, benzimidazoles and dicarboximides in Botrytis cinerea airborne inoculum. HRM analysis was applied directly in fungal DNA collected from air samplers with selective medium. Three a... | 25,196,894 | [
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Switch from intravitreal ranibizumab to bevacizumab for the treatment of neovascular age-related macular degeneration: clinical comparison. | To compare outcomes after switching from intravitreal ranibizumab to bevacizumab in neovascular age-related macular degeneration (AMD). A retrospective review of 110 eyes treated in a 1+PRN (pro re nata) clinical setting with ranibizumab that were switched to bevacizumab. Patients analyzed had at least 3 ranibizumab in... | 25,196,907 | [
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... |
Evidence for substrate binding-induced zwitterion formation in the catalytic Cys-His dyad of the SARS-CoV main protease. | The coronavirus main protease (M(pro)) represents an attractive drug target for antiviral therapy of coronavirus (CoV) infections, including severe acute respiratory syndrome (SARS). The SARS-CoV M(pro) and related CoV proteases have several distinct features, such as an uncharged Cys-His catalytic dyad embedded in a c... | 25,196,915 | [
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0.1251409,
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0.08808848,
0.04810691,
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-0.323516,
... |
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