title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Inhaled hydrogen gas therapy for prevention of noise-induced hearing loss through reducing reactive oxygen species. | Reactive oxygen species (ROS) that form in the inner ear play an important role in noise-induced hearing loss (NIHL). Recent studies have revealed that molecular hydrogen (H2) has great potential for reducing ROS. In this study, we examined the potential of hydrogen gas to protect against NIHL. We tested this hypothesi... | 25,196,919 | [
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Can gerontology be a science? | During the last half-century, research on aging has become more scientific in its self-representations. Paradoxically, however, it is not at all self-evident that gerontology can flourish as a comprehensive science. Highlighting major trends in the internal and external history of the field's evolution reveals why this... | 25,196,923 | [
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mRNA-based dendritic cell vaccines. | Cancer immunotherapy has been proposed as a powerful treatment modality. Active immunotherapy aspires to stimulate the patient's immune system, particularly T cells. These cells can recognize and kill cancer cells and can form an immunological memory. Dendritic cells (DCs) are the professional antigen-presenting cells ... | 25,196,947 | [
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Interlayer cation exchange stabilizes polar perovskite surfaces. | Global optimization is used to study the structure of the polar KTaO3 (001) surface. It is found that cation exchange near the surface leads to the most stable structure. This mechanism is likely to be general to metal oxides containing cations of differing charge. | 25,196,987 | [
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A randomized, double-blind phase 2 clinical trial of blosozumab, a sclerostin antibody, in postmenopausal women with low bone mineral density. | Sclerostin, a SOST protein secreted by osteocytes, negatively regulates formation of mineralized bone matrix and bone mass. We report the results of a randomized, double-blind, placebo-controlled multicenter phase 2 clinical trial of blosozumab, a humanized monoclonal antibody targeted against sclerostin, in postmenopa... | 25,196,993 | [
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Catalytic enantioselective addition of thioacids to trisubstituted nitroalkenes. | The first example of a catalytic enantioselective addition to and nitronate protonation of trisubstituted nitroalkenes to produce highly enantioenriched products with a tetrasubstituted carbon is reported. Thioacids added in excellent yields and with high enantioselectivities to both activated and unactivated nitroalke... | 25,196,997 | [
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Daily variation in lung function in COPD patients with combined albuterol and ipratropium: results from a 4-week, randomized, crossover study. | The bronchodilator response to short-acting β2-agonist and short-acting muscarinic antagonist monotherapies varies on a day-to-day basis within individual patients. The objective of this study was to compare daily variation in bronchodilator response to the combined use of albuterol and ipratropium with monotherapies i... | 25,197,005 | [
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HPV-related oropharyngeal cancer: Risk factors for treatment failure in patients managed with primary transoral robotic surgery. | The purpose of this study was to determine clinical factors that predict locoregional recurrence or distant metastasis in patients with human papillomavirus (HPV)-positive oropharyngeal cancer treated with surgery and guideline-indicated adjuvant therapy. We identified all presumed HPV-positive patients with oropharyng... | 25,197,014 | [
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Induction of potential protective immunity against enterotoxemia in calves by single or multiple recombinant Clostridium perfringens toxoids. | Cattle enterotoxemia caused by Clostridium perfringens toxins is a noncontagious, sporadic, and fatal disease characterized by sudden death. Strategies for controlling and preventing cattle enterotoxemia are based on systematic vaccination of herds with toxoids. Because the process of producing conventional clostridial... | 25,197,030 | [
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Chemoenzymatic synthesis of heparan sulfate and heparin. | Heparan sulfate is a polysaccharide that plays essential physiological functions in the animal kingdom. Heparin, a highly sulfated form of heparan sulfate, is a widely prescribed anticoagulant drug worldwide. The heparan sulfate and heparin isolated from natural sources are highly heterogeneous mixtures differing in th... | 25,197,032 | [
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Cell cycle-dependent adaptor complex for ClpXP-mediated proteolysis directly integrates phosphorylation and second messenger signals. | The cell-division cycle of Caulobacter crescentus depends on periodic activation and deactivation of the essential response regulator CtrA. Although CtrA is critical for transcription during some parts of the cell cycle, its activity must be eliminated before chromosome replication because CtrA also blocks the initiati... | 25,197,043 | [
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Quantifying the benefits of vehicle pooling with shareability networks. | Taxi services are a vital part of urban transportation, and a considerable contributor to traffic congestion and air pollution causing substantial adverse effects on human health. Sharing taxi trips is a possible way of reducing the negative impact of taxi services on cities, but this comes at the expense of passenger ... | 25,197,046 | [
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Ebf2 is a selective marker of brown and beige adipogenic precursor cells. | Brown adipocytes and muscle and dorsal dermis descend from precursor cells in the dermomyotome, but the factors that regulate commitment to the brown adipose lineage are unknown. Here, we prospectively isolated and determined the molecular profile of embryonic brown preadipose cells. Brown adipogenic precursor activity... | 25,197,048 | [
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Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation. | The roles of 2-oxoglutarate (2OG)-dependent prolyl-hydroxylases in eukaryotes include collagen stabilization, hypoxia sensing, and translational regulation. The hypoxia-inducible factor (HIF) sensing system is conserved in animals, but not in other organisms. However, bioinformatics imply that 2OG-dependent prolyl-hydr... | 25,197,067 | [
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Primed 3D injectable microniches enabling low-dosage cell therapy for critical limb ischemia. | The promise of cell therapy for repair and restoration of damaged tissues or organs relies on administration of large dose of cells whose healing benefits are still limited and sometimes irreproducible due to uncontrollable cell loss and death at lesion sites. Using a large amount of therapeutic cells increases the cos... | 25,197,069 | [
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Multiscale digital Arabidopsis predicts individual organ and whole-organism growth. | Understanding how dynamic molecular networks affect whole-organism physiology, analogous to mapping genotype to phenotype, remains a key challenge in biology. Quantitative models that represent processes at multiple scales and link understanding from several research domains can help to tackle this problem. Such integr... | 25,197,087 | [
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Transcriptome profiling reveals mosaic genomic origins of modern cultivated barley. | The domestication of cultivated barley has been used as a model system for studying the origins and early spread of agrarian culture. Our previous results indicated that the Tibetan Plateau and its vicinity is one of the centers of domestication of cultivated barley. Here we reveal multiple origins of domesticated barl... | 25,197,090 | [
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Epigenetic role for the conserved Fe-S cluster biogenesis protein AtDRE2 in Arabidopsis thaliana. | On fertilization in Arabidopsis thaliana, one maternal gamete, the central cell, forms a placenta-like tissue, the endosperm. The DNA glycosylase DEMETER (DME) excises 5-methylcytosine via the base excision repair pathway in the central cell before fertilization, creating patterns of asymmetric DNA methylation and mate... | 25,197,096 | [
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Role of transcutaneous electrical nerve stimulation in post-operative analgesia. | The use of transcutaneous electrical nerve stimulation (TENS) as non-pharmacological therapeutic modality is increasing. The types of TENS used clinically are conventional TENS, acupuncture TENS and intense TENS. Their working is believed to be based on gate control theory of pain and activation of endogenous opioids. ... | 25,197,104 | [
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Undetected hypoparathyroidism: An unusual cause of perioperative morbidity. | Routine investigation of serum calcium is not recommended in ASA one and two patients unless abnormalities of calcium metabolism are clinically suspected. The clinical features of hypocalcaemia can often be subtle and may manifest in the presence of associated factors. Hypoparathyroidism, an important cause of hypocalc... | 25,197,121 | [
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How Much Is Personality Structure Affected If One or More Highest-Level Factors Are First Removed? A Sequential Factors Approach. | Rotations of 1 to 12 factors were compared by Goldberg's "bass-ackward" method, with or without initially holding constant one or more principal components. Two sets of data were employed: ratings by 320 undergraduates using 435 personality-descriptive adjectives, and 512 Oregon community members' responses to 184 scal... | 25,197,156 | [
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Recent Developments in Molecular Simulation Approaches to Study Spherical Virus Capsids. | Viruses are a particularly challenging systems to study via molecular simulation methods. Virus capsids typically consist of over 100 subunit proteins and reach dimensions of over 100 nm; solvated viruses capsid systems can be over 1 million atoms in size. In this review, I will present recent developments which have a... | 25,197,162 | [
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Solid pseudo papillary tumor of pancreas: Presenting as acute abdomen in a female child. | Solid pseudo papillary tumor (SPT) or Frantz's tumor is a slow-growing low-grade malignant tumor, commonly seen in young patients with a female predominance, which is commonly located in the body and tail of the pancreas. We report a case of SPT arising from the body of the pancreas in a 12-year-old girl who presented ... | 25,197,185 | [
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Acute abdomen secondary to complete tubular colonic duplication. | We report the case of a 6-month-old infant who presented with a complete duplication of the large intestine, debuting clinically with acute abdomen and severe metabolic disorders. We discuss the pathogenesis and morphology of the lesions, diagnostic difficulties and peculiarities of surgical treatment. | 25,197,196 | [
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Three new caespitose species of Senecio (Asteraceae, Senecioneae) from South Peru. | Three new species of the genus Senecio (Asteraceae, Senecioneae) belonging to Senecio ser. Suffruticosi subser. Caespitosi were discovered in the tributaries of the upper Tambo River, Moquegua Department, South Peru. Descriptions, diagnoses and discussions about their distribution, a table with the morphological simila... | 25,197,221 | [
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Melicope balgooyi Appelhans, W.L. Wagner & K.R. Wood, a new species and new record in Melicope section Melicope (Rutaceae) for the Austral Islands. | Melicope balgooyi, a new species of Melicope (Rutaceae) is described. It is known only from the Austral Islands in the South Pacific (French Polynesia). However, it is not closely related to the other two species previously known from the Austral Islands, which are part of Melicope section Vitiflorae. The new species b... | 25,197,227 | [
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First description of the worker caste of Nylanderiasmythiesii (Hymenoptera: Formicidae). | The hitherto unknown worker caste of Nylanderiasmythiesii (Forel, 1894) is described for the first time. Sexuals are redescribed and photomontage images of all castes are provided. A key is presented to separate the six Indian species of Nylanderia. Previously described Nylanderiaassimilis (Jerdon, 1851) is considered ... | 25,197,237 | [
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Pure rotation of a prism on a ramp. | In this work, we study a prism with a cross section in polygon rolling on a ramp inclined at a small angle. The prism under gravity rolls purely around each individual edge, intermittently interrupted by a sequence of <iface collisions</i between the side face of the prism and the ramp. By limiting the prism in a plana... | 25,197,242 | [
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An elastica arm scale. | The concept of a 'deformable arm scale' (completely different from a traditional rigid arm balance) is theoretically introduced and experimentally validated. The idea is not intuitive, but is the result of nonlinear equilibrium kinematics of rods inducing configurational forces, so that deflection of the arms becomes n... | 25,197,248 | [
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On the initial value problem for the wave equation in Friedmann-Robertson-Walker space-times. | The propagator <iW</i(<it</i<sub0</sub,<it</i<sub1</sub)(<ig</i,<ih</i) for the wave equation in a given space-time takes initial data (<ig</i(<ix</i),<ih</i(<ix</i)) on a Cauchy surface {(<it</i,<ix</i) : <it</i=<it</i<sub0</sub} and evaluates the solution (<iu</i(<it</i<sub1</sub,<ix</i),∂ <sub<it</i</sub<iu</i(<it</... | 25,197,255 | [
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0.0178629,
0.0774422... |
Thermal conductivity of group-IV semiconductors from a kinetic-collective model. | The thermal conductivity of group-IV semiconductors (silicon, germanium, diamond and grey tin) with several isotopic compositions has been calculated from a kinetic-collective model. From this approach, significantly different to Callaway-like models in its physical interpretation, the thermal conductivity expression a... | 25,197,256 | [
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Effectiveness of multiple daily injections or continuous subcutaneous insulin infusion for children with type 1 diabetes mellitus in clinical practice. | Aims. To determine whether multiple daily injections (MDIs) or continuous subcutaneous insulin infusion (CSII) contributes to better glucose control in children with different type 1 diabetes duration. Methods. Subjects were grouped according to early (≤1 year after disease onset; 1A) or late (1-3 years after onset; 2A... | 25,197,275 | [
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Relationship between the Prevalence of Thyroid Nodules and Metabolic Syndrome in the Iodine-Adequate Area of Hangzhou, China: A Cross-Sectional and Cohort Study. | Objective. The association between thyroid nodule (TN) prevalence and metabolic syndrome (MetS) has only rarely been examined in iodine-adequate areas and needs further clarification. We investigated correlations between MetS and TN prevalence in the iodine-adequate area of Hangzhou, China. Material and Method. A cross... | 25,197,276 | [
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Differentiation of Xanthomonas spp. Causing Bacterial Spot in Bulgaria Based on Biolog System. | During the last 20 years, the causative agents of bacterial spot of tomato and pepper have been subjected to many studies and reclassifications. According to the current data, the species are four (X. euvesicatoria, X. vesicatoria, X. gardneri, and X. perforans) and cause similar symptoms in plants but possess differen... | 25,197,281 | [
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Diagnostic evaluation of uterine artery Doppler sonography for the prediction of adverse pregnancy outcomes. | Increased impedance to flow in the uterine arteries assessed by value of the Doppler is associated with adverse pregnancy outcomes, especially pre-eclampsia. We investigated the predictive value of a uterine artery Doppler in the identification of adverse pregnancy outcomes such as 'pre-eclampsia' and 'small fetus for ... | 25,197,292 | [
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Memantine add on to citalopram in elderly patients with depression: A double-blind placebo-controlled study. | Proper management of depression in elderly population would improve the outcome of the disease and reduce its related disability and mortality. Use of memantine with minimal side effects and drug interaction seems reasonable in the elderly but its antidepressant activity is controversial. The aim of the current researc... | 25,197,294 | [
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Potential therapeutic effects of meditation for treating affective dysregulation. | Affective dysregulation is at the root of many psychopathologies, including stress induced disorders, anxiety disorders, and depression. The root of these disorders appears to be an attenuated, top-down cognitive control from the prefrontal cortices over the maladaptive subcortical emotional processing. A form of menta... | 25,197,309 | [
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Understanding hypoglycemia in hospitalized patients. | Controlling blood glucose in hospitalized patients is important as both hyperglycemia and hypoglycemia are associated with increased cost, length of stay, morbidity and mortality. A limiting factor in stringent control is the concern of iatrogenic hypoglycemia. The association of hypoglycemia with mortality has led to ... | 25,197,322 | [
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A guide to histomorphological evaluation of intestinal inflammation in mouse models. | Histomorphology remains a powerful routine evaluating intestinal inflammation in animal models. Emphasizing the focus of a given animal study, histopathology can overstate differences between established models. We aimed to systematize histopathological evaluation of intestinal inflammation in mouse models facilitating... | 25,197,329 | [
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Concordant podoplanin expression in cancer-associated fibroblasts and tumor cells is an adverse prognostic factor in esophageal squamous cell carcinoma. | There is growing evidence that cancer-associated fibroblasts (CAFs) interact with tumor cells and play important roles in tumor progression and invasion. Podoplanin is a type-1 transmembrane glycoprotein expressed in a variety of normal human tissues, including lymphatic endothelium. Tumor cell expression of podoplanin... | 25,197,355 | [
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Autophagy may promote carcinoma cell invasion and correlate with poor prognosis in cholangiocarcinoma. | The role of autophagy in cholangiocarcinoma is poorly understood. This study investigated its involvement in cholangiocarcinoma, focusing on carcinoma cell invasion and prognostic significance using cholangiocarcinoma cell lines, CCKS1 and HuCCT1, and human tissues of hilar and extrahepatic cholangiocarcinoma. Nutrient... | 25,197,362 | [
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Upregulation of miR-137 protects anesthesia-induced hippocampal neurodegeneration. | Ketamine is commonly used in pediatric anesthesia but may cause neurodegeneration in young brains. The aim of the study is to use an animal model to characterize the role of microRNA 137 (miR-137) in ketamine-induced neurodegeneration in neonatal hippocampus. Young Sprague-Dawley Rats (1 month old) was systemically adm... | 25,197,371 | [
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Lycopene ameliorates renal function in rats with streptozotocin-induced diabetes. | To study the effect of lycopene on ameliorating renal function of diabetic nephropathy. Sixty male SD rats were divided into four groups: normal untreated (NC-U), normal treatment (NC-L), diabetes untreated (DM-U) and diabetes treatment (DM-L). DM was prepared by a single injection of STZ (70 mg/kg, intraperitoneally) ... | 25,197,372 | [
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Antepartum or immediate postpartum renal biopsies in preeclampsia/eclampsia of pregnancy: new morphologic and clinical findings. | Preeclampsia (PE) and eclampsia remain leading causes of maternal and fetal mortality worldwide. The kidney is considered the first and most severely affected organ in women with PE/eclampsia. In this study, we analyzed new morphologic features of kidney biopsies and clinical findings in patients with PE or eclampsia a... | 25,197,387 | [
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Synchronous gastric and sebaceous cancers, a rare manifestation of MLH1-related Muir-Torre syndrome. | Muir-Torre syndrome (MTS), a rare variant of the hereditary non polyposis colorectal cancer syndrome, is an autosomal dominant genodermatosis characterised by coincidence of sebaceous gland neoplasms (sebaceous adenoma, epithelioma, or carcinoma) and at least one internal malignancy. The underlying cause of MTS is a ge... | 25,197,397 | [
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A case of chronic hepatitis C patient of myocardial ischemia accompanied with interstitial pneumonia induced by pegylated interferon alpha-2a. | After 3 months of combination treatment using interferon α-2a and Ribavirin, a case of 59-year-old female patient with chronic viral hepatitis C demonstrated symptoms such as headache, dizziness accompanied by nausea, vomiting, dry cough, breathing difficulty, and shortness of breath. Dynamic electrocardiogram showed o... | 25,197,402 | [
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Unclassified mixed germ cell-sex cord-stromal tumor with multiple malignant cellular elements in a young woman: a case report and review of the literature. | Unclassified mixed germ cell-sex cord-stromal tumor composed of germ cells and sex cord derivatives is a rare neoplasm. Approximately 10% of such tumors have malignant germ cell components. We report the case of a 28 year-old female with a right adnexal mass measuring 8 cm in greatest dimension, containing areas with b... | 25,197,407 | [
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Retrograde tracing of medial vestibular nuclei connections to the kidney in mice. | Vestibular nuclei have been identified as a uniform multifunctional structure in order to maintain physiological homeostasis, including the participation of renal sympathetic activity. In this study, the medial vestibular nuclei (MVe) of 10 adult male C57BL/6J strain mice were mapped retrograde using injections of pseu... | 25,197,422 | [
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Genome sequence of the squalene-degrading bacterium Corynebacterium terpenotabidum type strain Y-11(T) (= DSM 44721(T)). | Corynebacterium terpenotabidum Takeuchi et. al 1999 is a member of the genus Corynebacterium, which contains Gram-positive and non-spore forming bacteria with a high G+C content. C. terpenotabidum was isolated from soil based on its ability to degrade squalene and belongs to the aerobic and non-hemolytic Corynebacteria... | 25,197,436 | [
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Complete genome sequence of Anabaena variabilis ATCC 29413. | Anabaena variabilis ATCC 29413 is a filamentous, heterocyst-forming cyanobacterium that has served as a model organism, with an extensive literature extending over 40 years. The strain has three distinct nitrogenases that function under different environmental conditions and is capable of photoautotrophic growth in the... | 25,197,444 | [
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Non-contiguous finished genome sequence of Anoxybacillus flavithermus subsp. yunnanensis type strain (E13(T)), a strictly thermophilic and organic solvent-tolerant bacterium. | Anoxybacillus flavithermus subsp. yunnanensis is the only strictly thermophilic bacterium that is able to tolerate a broad range of toxic solvents at its optimal temperature of 55-60°C. The type strain E13(T) was isolated from water-sediment slurries collected from a hot spring. This study presents the draft genome seq... | 25,197,458 | [
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High quality draft genome sequence of Staphylococcus cohnii subsp. cohnii strain hu-01. | Staphylococcus cohnii subsp. cohnii belongs to the family Staphylococcaceae in the order Bacillales, class Bacilli and phylum Firmicutes. The increasing relevance of S. cohnii to human health prompted us to determine the genomic sequence of Staphylococcus cohnii subsp. cohnii strain hu-01, a multidrug-resistant isolate... | 25,197,460 | [
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Complete genome sequence of invertebrate iridovirus IIV22A, a variant of IIV22, isolated originally from a blackfly larva. | Members of the family Iridoviridae are animal viruses that infect only invertebrates and poikilothermic vertebrates. The invertebrate iridoviruses 22 (IIV22) and 25 (IIV25) were originally isolated from a single sample of blackfly larva (Simulium spp., order Diptera) collected from the Ystwyth river near Aberystwyth, W... | 25,197,475 | [
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... |
High quality draft genome sequence of the slightly halophilic bacterium Halomonas zhanjiangensis type strain JSM 078169(T) (DSM 21076(T)) from a sea urchin in southern China. | Halomonas zhanjiangensis Chen et al. 2009 is a member of the genus Halomonas, family Halomonadaceae, class Gammaproteobacteria. Representatives of the genus Halomonas are a group of halophilic bacteria often isolated from salty environments. The type strain H. zhanjiangensis JSM 078169(T) was isolated from a sea urchin... | 25,197,480 | [
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... |
Non-contiguous finished genome sequence and description of Bacillus massilioalgeriensis sp. nov. | Strain EB01(T) sp. nov. is the type strain of Bacillus massilioalgeriensis, a new species within the genus Bacillus. This strain, whose genome is described here, was isolated from sediment sample of the hypersaline lake Ezzemoul sabkha in northeastern Algeria. B. massilioalgeriensis is a facultative anaerobic Gram-posi... | 25,197,482 | [
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Non-contiguous finished genome sequence and description of Anaerococcus provenciensis sp. nov. | Anaerococcus provenciensis strain 9402080(T) sp. nov. is the type strain of A. provenciensis sp. nov., a new species within the genus Anaerococcus. This strain was isolated from a cervical abscess sample. A. provenciensis is a Gram-positive anaerobic cocci. Here, we describe the features of this organism, together with... | 25,197,492 | [
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Genome sequence of the exopolysaccharide-producing Salipiger mucosus type strain (DSM 16094(T)), a moderately halophilic member of the Roseobacter clade. | Salipiger mucosus Martínez-Cànovas et al. 2004 is the type species of the genus Salipiger, a moderately halophilic and exopolysaccharide-producing representative of the Roseobacter lineage within the alphaproteobacterial family Rhodobacteraceae. Members of this family were shown to be the most abundant bacteria especia... | 25,197,501 | [
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The effect of weight reduction on ultrasonographic findings of nonalcoholic Fatty liver. | BACKGROUND Non-alcoholic fatty liver (NAFL) includes a spectrum of diseases ranging from simple hepatic steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis. NAFL is typically seen in association with obesity, diabetes and hypertriglyceridaemia. In order to seek the role of diet therapy in treatment of NAFL, ... | 25,197,505 | [
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Comparison of electrotherapy, rubber band ligation and hemorrhoidectomy in the treatment of hemorrhoids: a clinical and manometric study. | BACKGROUND Treatment of hemorrhoid disease is one of the most challenging fields in general surgery in which different methods are used to treat this condition. In this study, we compared the manometric and clinical results of three treatment methods for hemorrhoids. METHODS A total of 150 patients with symptomatic gra... | 25,197,506 | [
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... |
Prevalence of dyspepsia and its correlation with demographic factors and lifestyle in shiraz, southern iran. | BACKGROUND Dyspepsia is a common disorder that can present many clinical dilemmas in patient management. Although not life-threatening, the symptoms are long-lasting, interfere with daily activities and have a significant impact upon quality of life. The aim of this study was to determine prevalence of dyspepsia and it... | 25,197,509 | [
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Hepatocellular carcinoma in the world and the middle East. | Hepatocellular carcinoma (HCC) is a major worldwide public health concern. Despite recent advances, there has been little success in improving the survival of HCC patients. Due to advances in diagnostic modalities and the increasing incidence of chronic viral hepatitis and nonalcoholic fatty liver disease (NAFLD), both... | 25,197,510 | [
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Time Trends of Gastro-esophageal Reflux Disease (GERD) and Peptic Ulcer Disease (PUD) in Iran. | BACKGROUND Epidemiology of diseases changes over time with changes in socio-economic status, culture and health care systems. Gastroesophageal reflux disease (GERD) and peptic ulcer disease (PUD) are among the diseases whose epidemiology has changed over the past few decades in the west. Studies addressing the trend of... | 25,197,517 | [
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Repair of iatrogenic large colon perforation using laparoscopic methods. Case report and review of the literature. | Iatrogenic perforation of the colon during elective colonoscopy is a serious complication. Surgical treatment remains the standard of care. We report a patient with a large colonic perforation that occurred during a screening colonoscopy, successfully repaired with laparoscopic methods. Although the safety and efficacy... | 25,197,522 | [
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Assessment of propofol usefulness as an anesthetic agent during colonoscopy. | BACKGROUND Propofol is used as a sedative drug during colonoscopy. In this study we analyzed the adverse effects of propofol (i.e., hemodynamic and respiratory) on patients who underwent colonoscopies. METHODS This study was performed in Qom Province, Iran. In this study, 125 patients (63 females, 62 males) were enroll... | 25,197,531 | [
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Pegaferon in hepatitis C: Results of a Multicenter Study. | BACKGROUND Chronic hepatitis C (CHC) is a major contributor to cirrhosis and hepatocellular carcinoma and major global public health problem that causes mortality in both developed and developing countries.For the past decade, treatment with pegylated interferon (peg interferon α) and ribavirin (RBV) has been associate... | 25,197,541 | [
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Chronic myeloid leukemia with an e1a3 BCR-ABL fusion protein: transformation to lymphoid blast crisis. | Chronic myelogenous leukemia (CML) results from the neoplastic transformation of a hematopoietic stem cell. CML is cytogenetically characterized by the presence of the Philadelphia chromosome (Ph'). Most patients with CML express e13a2 or e14a2 mRNAs that result from a rearrangement of the major breakpoint cluster regi... | 25,197,554 | [
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Presence and characterisation of anaemia in diabetic foot ulceration. | Introduction. Diabetic foot ulceration (DFU) is the commonest cause of severe limb ischaemia in the western world. In diabetes mellitus, anaemia is frequently unrecognized, yet studies have shown that it is twice as common in diabetics compared with nondiabetics. We aimed to assess the incidence of anaemia and further ... | 25,197,565 | [
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How to evaluate adenomyosis in patients affected by endometriosis? | Objective. The aim of the study is to evaluate adenomyosis in patients undergoing surgery for different type of endometriosis. It is an observational study including women with preoperative ultrasound diagnosis of adenomyosis. Demographic data and symptoms were recorded (age, body mass index, parity, history of previou... | 25,197,569 | [
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Comparison of clinical efficacy of intravenous acetaminophen with intravenous morphine in acute renal colic: a randomized, double-blind, controlled trial. | The aim of this study was to compare the clinical efficacy of intravenous acetaminophen with intravenous morphine in acute renal colic pain management. In this double-blind controlled trial, patients aged 18-55 years, diagnosed with acute renal colic, who met the inclusion and exclusion criteria, were randomized into t... | 25,197,573 | [
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Melanocyte and melanoma cell activation by calprotectin. | Calprotectin, a heterodimer of S100A8 and S100A9, is a proinflammatory cytokine released from ultraviolet radiation-exposed keratinocytes. Calprotectin binds to Toll-like receptor 4, the receptor for advanced glycation end-products, and extracellular matrix metalloproteinase inducer on target cells to stimulate migrati... | 25,197,574 | [
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Growing teratoma syndrome. | Growing teratoma syndrome (GTS) is a rare clinical entity, which presents with enlarging teratomas masses of the retroperitoneum or other locations, occurring during or after systemic chemotherapy for the treatment of nonseminomatous germ cell of the testis (NSGCT), with normalised tumour markers. Awareness of this syn... | 25,197,607 | [
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Metastatic prostate adenocarcinoma posing as urothelial carcinoma of the right ureter: a case report and literature review. | This is a case report of a 67-year-old patient with distant metastasis of prostate cancer to the right ureter which caused hydronephrosis. At the beginning, both of the cytology of the morning urine and imaging findings were consistent with urothelial carcinoma. Nephroureterectomy was subsequently performed. Interestin... | 25,197,608 | [
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<i>Ex vivo</i> Expansion of Human Adult Pancreatic Cells with Properties of Distributed Stem Cells by Suppression of Asymmetric Cell Kinetics. | Transplantation therapy for type I diabetes (T1D) might be improved if pancreatic stem cells were readily available for investigation. Unlike macroscopic islets, pancreatic tissue stem cells could more easily access the retroperitoneal pancreatic environment and thereby might achieve more effective pancreatic regenerat... | 25,197,614 | [
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Recombinant factor VIIa use in patients presenting with intracranial hemorrhage. | Recombinant factor VIIa (rFVIIa) can be used for rapid INR normalization in life-threatening hemorrhage in anticoagulated patients. Dosing is unclear and may carry thromboembolic risks. We reviewed the use of rFVIIa at a comprehensive stroke and cerebrovascular center to evaluate dose effectiveness on INR reduction and... | 25,197,623 | [
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Parasites as biological tags to assess host population structure: Guidelines, recent genetic advances and comments on a holistic approach. | We review the use of parasites as biological tags of marine fishes and cephalopods in host population structure studies. The majority of the work published has focused on marine fish and either single parasite species or more recently, whole parasite assemblages, as biological tags. There is representation of host orga... | 25,197,624 | [
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CC chemokine ligand 18 correlates with malignant progression of prostate cancer. | CC chemokine ligand 18 (CCL18) promotes malignant behaviors of various human cancer types. However, its involvement in human prostate cancer has not been fully elucidated. The aim of this study was to investigate the role of CCL18 in PCa. Expression of CCL18 at mRNA and protein levels was detected using real-time qRT-P... | 25,197,632 | [
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Implementation of a computerized decision support system to improve the appropriateness of antibiotic therapy using local microbiologic data. | A prospective quasi-experimental study was undertaken in 218 patients with suspicion of nosocomial infection hospitalized in a polyvalent ICU where a new electronic device (GERB) has been designed for antibiotic prescriptions. Two GERB-based applications were developed to provide local resistance maps (LRMs) and prelim... | 25,197,643 | [
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LH pretreatment as a novel strategy for poor responders. | Poor response to ovarian stimulation is still a major problem in IVF. The study presents a new stimulation protocol evaluated in a suppopulation of very difficult young poor ovarian responders. The study consists in two sections. The first includes data from a randomized controlled study involving forty-three young pat... | 25,197,669 | [
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Autophagy, Warburg, and Warburg reverse effects in human cancer. | Autophagy is a highly regulated-cell pathway for degrading long-lived proteins as well as for clearing cytoplasmic organelles. Autophagy is a key contributor to cellular homeostasis and metabolism. Warburg hypothesized that cancer growth is frequently associated with a deviation of a set of energy generation mechanisms... | 25,197,670 | [
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Strut deformation in CFRP-strengthened reinforced concrete deep beams. | Strut-and-tie model (STM) method evolved as one of the most useful designs for shear critical structures and discontinuity regions (D-regions). It provides widespread applications in the design of deep beams as recommended by many codes. The estimation of bottle-shaped strut dimensions, as a main constituent of STM, is... | 25,197,698 | [
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Optimal sixteenth order convergent method based on quasi-Hermite interpolation for computing roots. | We have given a four-step, multipoint iterative method without memory for solving nonlinear equations. The method is constructed by using quasi-Hermite interpolation and has order of convergence sixteen. As this method requires four function evaluations and one derivative evaluation at each step, it is optimal in the s... | 25,197,701 | [
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Development of UHPC mixtures utilizing natural and industrial waste materials as partial replacements of silica fume and sand. | In the exploratory study presented in this paper, an attempt was made to develop different mixtures of ultrahigh performance concrete (UHPC) using various locally available natural and industrial waste materials as partial replacements of silica fume and sand. Materials such as natural pozzolana (NP), fly ash (FA), lim... | 25,197,709 | [
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Effect of Chocobar Ice Cream Containing Bifidobacterium on Salivary Streptococcus mutans and Lactobacilli: A Randomised Controlled Trial. | To examine the effect of chocobar ice cream containing bifidobacteria on salivary mutans streptococci and lactobacilli. A double-blind, randomised controlled trial was conducted with 30 subjects (18 to 22 years of age) divided into 2 groups, test (chocobar ice cream with probiotics) and control (chocobar ice cream with... | 25,197,733 | [
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... |
Overexpression of the Salmonella KdpF membrane peptide modulates expression of kdp genes and intramacrophage growth. | Membrane peptides appear as an emerging class of regulatory molecules in bacteria, which can interact with membrane proteins, including transporters and sensor kinases. The KdpF peptide, which is cotranscribed with kdpABC genes and regulated by the KdpDE two-component system, is supposed to stabilize the KdpABC potassi... | 25,197,761 | [
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0.01163079... |
Low Levels of Energy Expenditure in Childhood Cancer Survivors: Implications for Obesity Prevention. | Childhood cancer survivors are at an increased risk of obesity but causes for this elevated risk are uncertain. We evaluated total energy expenditure in childhood cancer survivors using the doubly labeled water method in a cross-sectional study of 17 survivors of pediatric leukemia or lymphoma (median age, 11.5 y). Mea... | 25,197,775 | [
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Dental visits time interval since last visit, United States - july 1963-june 1964. | Data collected during the period July 1963 and June 1964 indicate that an estimated 78.1 million persons, or 42.0 percent of the civilian, noninstitutional population, made one or more dental visits within the year prior to interview. Approximately 16.6 percent of the population had never seen a dentist. These data are... | 25,197,790 | [
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Electroencephalographic power spectral density profile of the orexin receptor antagonist suvorexant in patients with primary insomnia and healthy subjects. | Suvorexant, an orexin receptor antagonist, improves sleep in healthy subjects (HS) and patients with insomnia. We compared the electroencephalographic (EEG) power spectral density (PSD) profile of suvorexant with placebo using data from a phase 2 trial in patients with insomnia. We also compared suvorexant's PSD profil... | 25,197,807 | [
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The contribution of bone and cartilage to the near-infrared spectrum of osteochondral tissue. | Near-infrared (NIR) spectroscopy has been used to assess hyaline cartilage quality in human and animal osteochondral tissues. However, due to the lack of NIR signal from bone phosphate and the relatively deep penetration depth of the radiation, the separate contributions of cartilage and bone to the spectral signatures... | 25,197,817 | [
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A small library of synthetic di-substituted 1, 4-naphthoquinones induces ROS-mediated cell death in murine fibroblasts. | Synthesis of compound libraries and their concurrent assessment as selective reagents for probing and modulating biological function continues to be an active area of chemical biology. Microwave-assisted solid-phase Dötz benzannulation reactions have been used to inexpensively synthesize 2, 3-disubstituted-1, 4-naphtho... | 25,197,824 | [
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The knowledge translation status in selected Eastern-Mediterranean universities and research institutes. | A serious worldwide effort to strengthen research based knowledge translation (KT) has begun in recent years and some countries, particularly developed ones, are trying to incorporate KT in their health and health research systems. Keeping in mind the recent economic depression and the need to perform more efficient re... | 25,197,834 | [
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Prognostic impact of renal dysfunction does not differ according to the clinical profiles of patients: insight from the acute decompensated heart failure syndromes (ATTEND) registry. | Renal dysfunction associated with acute decompensated heart failure (ADHF) is associated with impaired outcomes. Its mechanism is attributed to renal arterial hypoperfusion or venous congestion, but its prognostic impact based on each of these clinical profiles requires elucidation. ADHF syndromes registry subjects wer... | 25,197,833 | [
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The place of mathematical models in psychology and the social sciences. | Comments on the comments made by Brown et al. (see record 2013-24609-001). Brown et al. presented a scathing critique of the work of Fredrickson and Losada (see record 2005-11834-001) on the use of advanced mathematical methods (specifically, nonlinear dynamics) in describing changes in human emotions over time, termin... | 25,197,849 | [
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G-loading and vibration effects on heart and respiration rates. | Operational environments expose pilots and astronauts to sustained acceleration (G loading) and whole-body vibration, alone and in combination. Separately, the physiological effects of G loading and vibration have been well studied; both have effects similar to mild exercise. The few studies of combined G loading and v... | 25,197,894 | [
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Bilastine as a potential treatment in allergic rhinitis. | Allergic rhinitis is a very frequent disease. H1 antihistamines have been used for treatment of allergic rhinitis for more than 5 decades. They differ in chemical structure, pharmacokinetics, pharmacodynamics, clinical efficacy and adverse effects. We performed a detailed analysis of all available publications concerni... | 25,197,918 | [
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Sinonasal sarcoidosis: A new system of classification acting as a guide to diagnosis and treatment. | The signs and symptoms of sinonasal sarcoidosis are diverse and nonspecific. It easily mimics more common sinonasal disorders such as allergic rhinitis, bacterial sinusitis, and atrophic rhinitis. The purpose of this study was to develop a classification system of sinonasal sarcoidosis that will help serve as a guide f... | 25,197,919 | [
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Study of leaf metabolome modifications induced by UV-C radiations in representative Vitis, Cissus and Cannabis species by LC-MS based metabolomics and antioxidant assays. | UV-C radiation is known to induce metabolic modifications in plants, particularly to secondary metabolite biosynthesis. To assess these modifications from a global and untargeted perspective, the effects of the UV-C radiation of the leaves of three different model plant species, Cissus antarctica Vent. (Vitaceae), Viti... | 25,197,936 | [
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Ginsenoside 20(S)-Rg3 targets HIF-1α to block hypoxia-induced epithelial-mesenchymal transition in ovarian cancer cells. | The prognosis of patients with ovarian cancer has remained poor mainly because of aggressive cancer progression. Since epithelial-mesenchymal transition (EMT) is an important mechanism mediating invasion and metastasis of cancer cells, targeting the EMT process with more efficacious and less toxic compounds to inhibit ... | 25,197,976 | [
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ASC spheroid geometry and culture oxygenation differentially impact induction of preangiogenic behaviors in endothelial cells. | Cell-based angiogenic therapies offer potential for the repair of ischemic injuries, while avoiding several of the limitations associated with material-based growth factor delivery strategies. Evidence supports that applying MSCs as spheroids rather than dispersed cells can improve retention and enhance therapeutic eff... | 25,197,983 | [
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The effect of sodium hypochlorite application on the success of calcium hydroxide and mineral trioxide aggregate pulpotomies in primary teeth. | This study's purpose was to evaluate the success of calcium hydroxide (CH) and mineral trioxide aggregate (MTA) pulpotomies following the use of five percent sodium hypochlorite (NaOCl) as an antibacterial agent to clean the chamber prior to application of the pulpotomy agent. A total of 128 teeth were randomly divided... | 25,197,997 | [
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Feasibility of frequency-modulated wireless transmission for a multi-purpose MEMS-based accelerometer. | Recent advances in the Micro Electro-Mechanical System (MEMS) technology have made wireless MEMS accelerometers an attractive tool for Structural Health Monitoring (SHM) of civil engineering structures. To date, sensors' low sensitivity and accuracy--especially at very low frequencies--have imposed serious limitations ... | 25,198,003 | [
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