title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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[Antitumor effect of Stichopus japonicus acidic mucopolysaccharide combined with fluorouracil in mice bearing neoplasia of H22 hepatoma cells]. | To observe the antitumor effect of Stihopus japonicus acidic mucopolysaccharide combined with fluorouracil in mice bearing neoplasia of H22 hepatoma cells, and study the mechanism. Inoculate the H22 liver cancer cells in the right forelimbs axillary region subcutaneous of 50 Kunming mice, and then randomly divide the m... | 25,199,288 | [
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[Efficiency evaluation of capsaicinoids to discriminate bio-waste oils from edible vegetable oils]. | To evaluate the efficiency of capsaicinoids to discriminate bio-waste oil from edible vegetable oil. 14 raw vegetable oils, 24 fried waste oils, 34 kitchen-waste oils, 32 edible non-peanut vegetable oil, 32 edible peanuts oil, 16 edible oil add flavorand and 11 refined bio-waste oils were prepared and examined for caps... | 25,199,291 | [
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[Simultaneous determination of 15 polycyclic aromatic hydrocarbons additives in vegetable oil by ultra performance liquid chromatography]. | To establish a rapid method for simultaneous determination of 15 polycyclic aromatic hydrocarbons (PAHs) in vegetable oil by ultra performance liquid chromatography with fluorescence detection. The vegetable oils were extracted with acetonitrile and acetone (1:1), purified with Oasis HLB and Sep-Pak Florsil column, sep... | 25,199,292 | [
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[Evolution of the response to the first-line therapy for Helicobacter pylori infection in Uruguay]. | The eradication rate of the Helicobacter pylori (H pylori) infection using standard triple therapy has dropped globally in recent years, primarily due to the occurrence of antibiotic resistance. Several therapy regimens were assessed in 823 patients treated the first time for H pylori infection in Uruguay, during the 1... | 25,199,301 | [
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[Monitoring of jugular venous oxygen saturation during superficial temporal artery-middle cerebral artery anastomosis under intraaortic balloon pumping: a case report]. | A 77-year-old man scheduled for coronary artery bypass grafting underwent left superficial temporal artery-middle cerebral artery anastomosis (STA MCA). Before anesthesia, we planned to insert an intraaortic balloon pump as a perioperative circulatory assist. In addition, a fiberoptic catheter was inserted in the proxi... | 25,199,325 | [
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[Case of respiratory arrest during intraoperative magnetic resonance imaging (iMRI) for awake craniotomy]. | We had a neurosurgical patient who developed apnea during iMRI. She was suspected of obstructive sleep apnea. The tumor had a risk of motor aphasia, and therefore awake craniotomy with iMRI was planned. First, the patient was anesthetized and her airway was secured. After 11 minutes of termination of anesthetics, the p... | 25,199,330 | [
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[Rubella immunity in Japanese women of childbearing age, 2008-2013: commercial diagnostic laboratory data analysis]. | For effective non-routine vaccination in women of childbearing age as a countermeasure against congenital rubella syndrome (CRS), it is important to know the specific age group in which fewer members have rubella immunity. We analyzed rubella hemagglutination-inhibition (HI) antibody data (about 890,000) accumulated fr... | 25,199,379 | [
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Anger-related dysregulation as a factor linking childhood physical abuse and interparental violence to intimate partner violence experiences. | Childhood family violence exposure is associated with increased risk for experiencing intimate partner violence (IPV) in adulthood, but the mechanisms underlying this relationship remain inadequately understood. Difficulties with emotion regulation may be one factor that helps to explain this relationship. Childhood ph... | 25,199,386 | [
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Robotic total hip arthroplasty. | Modern total hip replacement is typically effective and durable, but early failures do occur. Component position influences functional outcome, durability, and risk of complications. Surgical robotics provides the detail-oriented surgeon with a robust tool to optimize the accuracy and precision of total hip arthroplast... | 25,199,417 | [
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Management of traumatic bone loss in the lower extremity. | Segmental bone loss represents a difficult clinical entity for the treating orthopedic surgeon. This article discusses the various treatment modalities available for limb reconstruction, with a focus on the indications, potential complications, and the outcomes of available treatment options. | 25,199,419 | [
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Factors impacting biotransformation kinetics of trace organic compounds in lab-scale activated sludge systems performing nitrification and denitrification. | To predict TOrC fate in biological activated sludge systems, there is a need to accurately determine TOrC biodegradation kinetics in mixed microbial cultures. Short-term batch tests with salicylic acid, 17α-ethinylestradiol, nonylphenol, trimethoprim and carbamazepine were conducted with lab-scale activated sludge cult... | 25,199,437 | [
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Optimization of hydrostatic pressure at varied sonication conditions--power density, intensity, very low frequency--for isothermal ultrasonic sludge treatment. | This work aims at investigating for the first time the key sonication (US) parameters: power density (DUS), intensity (IUS), and frequency (FS) - down to audible range, under varied hydrostatic pressure (Ph) and low temperature isothermal conditions (to avoid any thermal effect). The selected application was activated ... | 25,199,444 | [
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A skellam model to identify differential patterns of gene expression induced by environmental signals. | RNA-seq, based on deep-sequencing techniques, has been widely employed to precisely measure levels of transcripts and their isoforms expressed under different conditions. However, robust statistical tools used to analyze these complex datasets are lacking. By grouping genes with similar expression profiles across treat... | 25,199,446 | [
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Development of the NIH Patient-Reported Outcomes Measurement Information System (PROMIS) gastrointestinal symptom scales. | The National Institutes of Health (NIH) Patient-Reported Outcomes Measurement Information System (PROMIS(®)) is a standardized set of patient-reported outcomes (PROs) that cover physical, mental, and social health. The aim of this study was to develop the NIH PROMIS gastrointestinal (GI) symptom measures. We first cond... | 25,199,473 | [
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Controlling the efficiency of trapping in a scale-free small-world network. | Designing appropriate techniques to effectively control the trapping process in complex systems towards desirable efficiency is of paramount importance in the study of trapping problem. In this paper, we present three different methods guiding trapping process in a scale-free small-world network with a deep trap positi... | 25,199,481 | [
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[Objective refraction in black children: cyclopentolate and tropicamide combination, a reliable alternative to atropine?]. | Cycloplegia allows for an objective refraction in children. Atropine is the gold standard but causes prolonged blurred vision. Cyclopentolate is less effective but less disabling. Tropicamide is a weak cycloplegic. The purpose of this study was to evaluate a cyclopentolate and tropicamide combination (CTA) versus atrop... | 25,199,485 | [
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Hypoxia and Serum deprivation protected MiaPaCa-2 cells from KAI1-induced proliferation inhibition through autophagy pathway activation in solid tumors. | KAI1 closely correlates with pancreatic cancer metastasis. There might be some factors that protect the cells from a proliferation inhibition by KAI1 in the solid tumors' microenvironment. Hypoxia and ischemia are the main characteristics of the microenvironment within solid tumors. Whether they affect the KAI1 inhibit... | 25,199,507 | [
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Evaluation of the impact of universal testing for gestational diabetes mellitus on maternal and neonatal health outcomes: a retrospective analysis. | Gestational diabetes (GDM) affects a substantial proportion of women in pregnancy and is associated with increased risk of adverse perinatal and long term outcomes. Treatment seems to improve perinatal outcomes, the relative effectiveness of different strategies for identifying women with GDM however is less clear.This... | 25,199,524 | [
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Should mammalian target of rapamycin inhibitors be stopped in women with lymphangioleiomyomatosis awaiting lung transplantation? | Lymphangioleiomyomatosis (LAM) is a rare cystic lung disease characterized by proliferation of smooth muscle like cells (LAM cells) that have mutations in the tuberous sclerosis gene (TSC2), leading to the activation of the mammalian target of rapamycin (mTOR). Rapamycin, an inhibitor of the mTOR pathway, has been show... | 25,199,529 | [
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Maize protein phosphatase gene family: identification and molecular characterization. | Protein phosphatases (PPs) play critical roles in various cellular processes through the reversible protein phosphorylation that dictates many signal transduction pathways among organisms. Recently, PPs in Arabidopsis and rice have been identified, while the whole complement of PPs in maize is yet to be reported. In th... | 25,199,535 | [
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Modeling interactions between Human Equilibrative Nucleoside Transporter-1 and other factors involved in the response to gemcitabine treatment to predict clinical outcomes in pancreatic ductal adenocarcinoma patients. | Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy, characterized by largely unsatisfactory responses to the currently available therapeutic strategies. In this study we evaluated the expression of genes involved in gemcitabine uptake in a selected cohort of patients with PDAC, with well-defi... | 25,199,538 | [
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Adenosine as a probing tool for the mechanistic study of acupuncture treatment. | To date, acupuncture has been widely used despite a lack of solid clinical evidence in the East and West. However, there are few validated in vitro models for the mechanistic studies of acupuncture. We hypothesized that adenosine could be used as a probing tool in the mechanistic studies of acupuncture because of its c... | 25,199,539 | [
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Cell-penetrating peptide delivery of biologically active oct4 protein into cultured Takifugu rubripes spermary cells. | Continuous cell culture of a puffer fish Takifugu rubripes has been established for efficient delivery of exogenous genes or proteins to cultured fish cells. Transcription factor oct4 was chosen for transduction into cultured fish cells because of its conserved structure and function between fish and mammals. In this w... | 25,199,543 | [
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The geographical distribution and first molecular analysis of Culicoides Latreille (Diptera: Ceratopogonidae) species in the Southern and Southeastern Turkey during the 2012 outbreak of bovine ephemeral fever. | This study investigated the geographical distribution and molecular analysis of Culicoides species in the Southern and Southeastern Turkey during the 2012 outbreak of bovine ephemeral fever (BEF). The midge specimens caught by Onderstepoort-type light traps from livestock farms were tested for molecular evidence of exi... | 25,199,552 | [
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Acaricidal properties of the formulations based on essential oils from Cymbopogon winterianus and Syzygium aromaticum plants. | The cattle tick, Rhipicephalus (Boophilus) microplus, has caused serious harm to livestock raising in Brazil, considering the costs of controlling it, loss of revenue due to smaller production of milk and meat, and damage to leather, in addition to transmitting diseases. The use of medicinal plants is considered an alt... | 25,199,555 | [
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Functional expression of a novel alkaline-adapted lipase of Bacillus amyloliquefaciens from stinky tofu brine and development of immobilized enzyme for biodiesel production. | Using enrichment procedures, a lipolytic strain was isolated from a stinky tofu brine and was identified as Bacillus amyloliquefaciens (named B. amyloliquefaciens Nsic-8) by morphological, physiological, biochemical tests and 16S rDNA sequence analysis. Meanwhile, the key enzyme gene (named lip BA) involved in ester me... | 25,199,563 | [
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An assessment of the embryotoxicity of cadmium in the terrestrial mollusk Cantareus aspersus: from bioaccumulation to impacts at different levels of biological organization. | This study aims to determine various parameters that allow the evaluation of the toxicity of chemicals to embryos of the ubiquitous land snail Cantareus aspersus. For this purpose, we investigated morphological and physiological endpoints in control embryos and in embryos exposed to a solution of 6mg Cd/L (CdCl2) in a ... | 25,199,587 | [
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Simultaneous glucose sensing and biohydrogen evolution from direct photoelectrocatalytic glucose oxidation on robust Cu₂O-TiO₂ electrodes. | We report simultaneous photoelectrocatalytic (PEC) glucose sensing and biohydrogen generation for the first time from the direct PEC oxidation of glucose at multifunctional and robust Cu2O-TiO2 photocatalysts. Striking improvement of 30% in overall H2 gas evolution (∼122 μmol h(-1) cm(-2)) by photoholes assisted glucos... | 25,199,593 | [
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Atmospheric carbonaceous aerosols from Indo-Gangetic Plain and Central Himalaya: impact of anthropogenic sources. | In the present-day scenario of growing anthropogenic activities, carbonaceous aerosols contribute significantly (∼20-70%) to the total atmospheric particulate matter mass and, thus, have immense potential to influence the Earth's radiation budget and climate on a regional to global scale. In addition, formation of seco... | 25,199,599 | [
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The roles of scene gist and spatial dependency among objects in the semantic guidance of attention in real-world scenes. | A previous study (Vision Research 51 (2011) 1192-1205) found evidence for semantic guidance of visual attention during the inspection of real-world scenes, i.e., an influence of semantic relationships among scene objects on overt shifts of attention. In particular, the results revealed an observer bias toward gaze tran... | 25,199,610 | [
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Randomized controlled trial of a scoring aid to improve Glasgow Coma Scale scoring by emergency medical services providers. | Emergency medical services (EMS) personnel frequently use the Glasgow Coma Scale (GCS) to assess injured and critically ill patients. This study assesses the accuracy of EMS providers' GCS scoring, as well as the improvement in GCS score assessment with the use of a scoring aid. This randomized, controlled study was co... | 25,199,613 | [
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0.3043094... |
A mixed MDPV and benzodiazepine intoxication in a chronic drug abuser: determination of MDPV metabolites by LC-HRMS and discussion of the case. | We report on a case of repeated MDPV consumptions that resulted in severe psychosis and agitation prompting the concomitant abuse of benzodiazepines. A 27-year-old man was found irresponsive in his apartment and was brought to the emergency department (ED) of a local hospital. When in ED, he rapidly recovered and self-... | 25,199,615 | [
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0.01388792,
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The Individualized Diet and Exercise Adherence Pilot Trial (IDEA-P) in prostate cancer patients undergoing androgen deprivation therapy: study protocol for a randomized controlled trial. | Androgen deprivation therapy (ADT) is the foundation of treatment for men with metastatic prostate cancer and is now frequently incorporated into multimodality strategies for the curative treatment of locally advanced prostate cancer. Nevertheless, the catabolic effects of ADT result in meaningful adverse effects on ph... | 25,199,619 | [
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Suberoylanilide hydroxamic acid enhances the antitumor activity of oxaliplatin by reversing the oxaliplatin‑induced Src activation in gastric cancer cells. | Oxaliplatin and the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA), also known as vorinostat, are potent antitumor agents. The aim of this study was to investigate the effect of SAHA on the antitumor efficacy of oxaliplatin in gastric cancer and the interaction between oxaliplatin and SAHA. Cell g... | 25,199,623 | [
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Using triple-helix-forming Peptide nucleic acids for sequence-selective recognition of double-stranded RNA. | Non-coding RNAs play important roles in regulation of gene expression. Specific recognition and inhibition of these biologically important RNAs that form complex double-helical structures will be highly useful for fundamental studies in biology and practical applications in medicine. This protocol describes a strategy ... | 25,199,637 | [
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In vitro selection of a new lanthanide-dependent DNAzyme for ratiometric sensing lanthanides. | Developing biosensors for lanthanides is an important but challenging analytical task. To address this problem, in vitro selection of RNA-cleaving DNAzymes was carried out using a library containing a region of 35 random nucleotides in the presence of Lu(3+), since Lu(3+) was reported to be the most efficient lanthanid... | 25,199,650 | [
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High-altitude multi-taskers: bumble bee food plant use broadens along an altitudinal productivity gradient. | We use an extensive historical data set on bumble bee host choice collected almost 50 years ago by L. W. Macior (Melanderia 15:1-59, 1974) to examine how resource partitioning by bumble bees varies over a 2,700-m altitudinal gradient at four hierarchical scales: individual, colony, species and community. Bumble bee beh... | 25,199,658 | [
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Molecular cloning and characterization of Babesia orientalis rhoptry-associated protein 1. | The rhoptry-associated protein 1 (RAP-1) gene of Babesia orientalis was obtained from a cDNA expression library by immunoscreening with B. orientalis-infected water buffalo sera. The nucleotide sequence of the cDNA was 1732 bp with an open reading frame (ORF) of 1434 bp, encoding a polypeptide of 478 amino acid residue... | 25,199,690 | [
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Effect of cinnamon and its procyanidin-B2 enriched fraction on diabetic nephropathy in rats. | Non-enzymatic protein glycation and resultant accumulation of advanced glycation endproducts (AGE) are implicated in the pathogenesis of diabetic complications including diabetic nephropathy (DN). It is considered that antiglycating agents offer protection against AGE mediated pathologies including DN. Earlier we chara... | 25,199,697 | [
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[Medical treatment of uric acid stone]. | The medical treatment of uric acid stones is essential to its management. It allows the dissolution of the stones and prevents the formation of new ones. This treatment is based on a large diuresis, an alkanilization of the urines and diet. In most of the cases, the medical treatment avoids the use of surgical procedur... | 25,199,725 | [
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Influence of size and site of perforation on fat graft myringoplasty. | In this retrospective study, we investigated the outcomes of fat graft myringoplasty (FGM) in different perforation sizes and locations. The outcomes were evaluated in terms of closure rates and audiological test results. The study population included 172 patients who were operated between 2007 and 2012. 161 had unilat... | 25,199,735 | [
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Risk factors associated with severity of eosinophilic otitis media. | Eosinophilic otitis media (EOM) is an intractable otitis media associated with bronchial asthma. Clinical characteristics of EOM are apparent, but severe EOM, which is unresponsive to ongoing treatments, can occur. The present study aimed to investigate potential risk factors associated with the severity of EOM. We sco... | 25,199,747 | [
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The capsid binder Vapendavir and the novel protease inhibitor SG85 inhibit enterovirus 71 replication. | Antivirals against enterovirus 71 (EV71) are urgently needed. We demonstrate that the novel enteroviral protease inhibitor (PI) SG85 and capsid binder (CB) vapendavir efficiently inhibit the in vitro replication of 21 EV71 strains/isolates that are representative of the different genogroups A, B, and C. The PI rupintri... | 25,199,773 | [
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0.2722783,
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... |
Selective generation of formamides through photocatalytic CO2 reduction catalyzed by ruthenium carbonyl compounds. | The selective formation of dialkyl formamides through photochemical CO2 reduction was developed as a means of utilizing CO2 as a C1 building block. Photochemical CO2 reduction catalyzed by a [Ru(bpy)2(CO)2](2+) (bpy: 2,2'-bipyridyl)/[Ru(bpy)3](2+)/Me2NH/Me2NH2(+) system in CH3CN selectively produced dimethylformamide. ... | 25,199,795 | [
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0... |
Prolonged tumor necrosis factor α primes fibroblast-like synoviocytes in a gene-specific manner by altering chromatin. | During the course of rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLS) are chronically exposed to an inflammatory milieu. The purpose of this study was to test the hypothesis that prolonged exposure of FLS to tumor necrosis factor α (TNFα) augments inflammatory responses to secondary stimuli (priming effect... | 25,199,798 | [
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0.07177144,
0.1806133,
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Effects of phenylalanine and threonine oligopeptides on milk protein synthesis in cultured bovine mammary epithelial cells. | This study was conducted to investigate the effects of phenylalanine (Phe) and threonine (Thr) oligopeptides on αs1 casein gene expression and milk protein synthesis in bovine mammary epithelial cells. Primary mammary epithelial cells were obtained from Holstein dairy cows and incubated in Dulbecco's modified Eagle's m... | 25,199,802 | [
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0.04695896,
0.1597798,
0.2208505,
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Linking the Legislative Process to the Consequences of Realigning California's Public Mental Health System. | In 1991, California transferred significant responsibility, resources, and accountability for public mental health from the state to its 58 counties. Using purposeful sampling, we conducted in-depth interviews with ten senior state and county leaders to gain insights into the relatively uncharted area of their understa... | 25,199,814 | [
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0.3253274,
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AMPK modulates tissue and organismal aging in a non-cell-autonomous manner. | AMPK exerts prolongevity effects in diverse species; however, the tissue-specific mechanisms involved are poorly understood. Here, we show that upregulation of AMPK in the adult Drosophila nervous system induces autophagy both in the brain and also in the intestinal epithelium. Induction of autophagy is linked to impro... | 25,199,830 | [
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0.1463185,
0.1106339,
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Alternative 3' UTR selection controls PAR-5 homeostasis and cell polarity in C. elegans embryos. | Cell polarity in one-cell C. elegans embryos guides asymmetric cell division and cell-fate specification. Shortly after fertilization, embryos establish two antagonistic cortical domains of PAR proteins. Here, we find that the conserved polarity factor PAR-5 regulates PAR domain size in a dose-dependent manner. Using q... | 25,199,833 | [
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Binding-pocket and lid-region substitutions render human STING sensitive to the species-specific drug DMXAA. | The drug DMXAA (5,6-dimethylxanthenone-4-acetic acid) showed therapeutic promise against solid tumors in mouse models but subsequently failed in human clinical trials. DMXAA was later discovered to activate mouse, but not human, STING, an adaptor protein in the cyclic dinucleotide cGAMP-mediated signaling pathway, indu... | 25,199,835 | [
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... |
Effect of surfactant and budesonide on the pulmonary distribution of fluorescent dye in mice. | Surfactant is a useful vehicle for the intratracheal delivery of medicine to the distal lung. The aim of this study was to analyze the effect of intratracheal surfactant and budesonide instillation on the pulmonary distribution of fluorescent dye in mice. Male athymic nude mice were assigned randomly as controls, fluor... | 25,199,848 | [
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0.2036994,
0.188188,
0.1781446,
0.02254447,
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Psyllium arabinoxylan: carboxymethylation, characterization and evaluation for nanoparticulate drug delivery. | The objective of present investigation was to optimize the interaction between carboxymethylated psyllium arabinoxylan and chitosan to prepare polyelectrolyte naoparticles for drug delivery applications. Arabinoxylan extracted from psyllium was carboxymethylated by reacting with monochloroacetic acid under alkaline con... | 25,199,870 | [
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0.2421504,
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Clinical characteristics of three subtypes of spinal muscular atrophy in children. | The severity of spinal muscular atrophy (SMA) is highly variable and children with heterogeneous clinical features can be classified into three phenotypes (type I-III) on the basis of age of onset and maximum motor function achieved. The aim of this study was to compare the clinical characteristics of three phenotypes ... | 25,199,871 | [
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Comparative analysis of the composition of intestinal bacterial communities in Dastarcus helophoroides fed different diets. | The diversity of the intestinal bacterial communities in Dastarcus helophoroides (Fairmaire) (Coleoptera: Bothrideridae) larvae and adults was assayed by PCR-DGGE to determine whether different artificial diets could influence these bacterial communities. Two diets were used for feeding the larvae and four for the adul... | 25,199,878 | [
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Scavenger receptor CL-P1 mainly utilizes a collagen-like domain to uptake microbes and modified LDL. | Collectins are considered to play a role in host defense via complement activation and opsonization, and are composed of a collagen-like domain and a carbohydrate recognition domain (CRD). Collectin placenta 1 (CL-P1) showed scavenger receptor activity as functions in vitro, and has three candidate domains: a coiled-co... | 25,199,873 | [
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Emerging lessons from regional and state innovation in value-based payment reform: balancing collaboration and disruptive innovation. | In recent decades, practitioners and policymakers have turned to value-based payment initiatives to help contain spending on health care and to improve the quality of care. The Robert Wood Johnson Foundation funded 7 grantees across the country to design and implement value-based, multistakeholder payment reform projec... | 25,199,900 | [
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Protecting-group-free one-pot synthesis of glycoconjugates directly from reducing sugars. | The conversion of sugars into glycomimetics typically involves multiple protecting-group manipulations. The development of methodology allowing the direct aqueous conversion of free sugars into glycosides, and mimics of oligosaccharides and glycoconjugates in a high-yielding and stereoselective process is highly desira... | 25,199,905 | [
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Comparative effects of light or heavy resistance power training for improving lower extremity power and physical performance in mobility-limited older adults. | We compared the effects of two uniquely different lower extremity power training interventions on changes in muscle power, physical performance, neuromuscular activation, and muscle cross sectional area in mobility-limited older adults. Fifty-two subjects (78±5 years, short physical performance battery score: 8.1±1) we... | 25,199,912 | [
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Impact of functional change before and during hospitalization on functional recovery 1 month following hospitalization. | The functional changes that occur immediately before acute hospitalization and those that occur during hospitalization are pertinent to posthospitalization functional status in older adults. Our primary aim was to estimate the effects of membership in categories that take into account pre- and within-hospital functiona... | 25,199,914 | [
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Long-term hypo-osmoregulatory capacity in downstream migrating Atlantic salmon Salmo salar L. smolts. | The duration of hypo-osmoregulatory capacity in downstream migrating Atlantic salmon Salmo salar L smolts previously stocked as startfed young-of-the year (YOY) parr was tested in the River Dalåa from mid-May to late-June 1999. Hypo-osmoregulatory capacity, measured as plasma osmolality and chloride, was assessed after... | 25,199,923 | [
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[Metamizole (dipyrone): mode of action, drug-drug interactions, and risk of agranulocytosis]. | Metamizole (dipyrone) is a nonsteroidal compound with strong analgesic as well as antipyretic and spasmolytic properties. Based on a small number of cases of agranulocytosis, metamizole was withdrawn from the market in some countries. Other countries restricted its use. This paper discusses the safety aspects of metami... | 25,199,942 | [
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Time-related changes in determinants of antiplatelet effect of clopidogrel in patients after myocardial infarction. | Substantial variability of antiplatelet action is an important limitation of clopidogrel. The aim of this study was to evaluate time-related changes in determinants of clopidogrel responsiveness in patients after myocardial infarction. The study population comprised 191 consecutive patients treated with primary percuta... | 25,199,965 | [
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HR-MAS MRS of the pancreas reveals reduced lipid and elevated lactate and taurine associated with early pancreatic cancer. | The prognosis for patients with pancreatic cancer is extremely poor, as evidenced by the disease's five-year survival rate of ~5%. New approaches are therefore urgently needed to improve detection, treatment, and monitoring of pancreatic cancer. MRS-detectable metabolic changes provide useful biomarkers for tumor detec... | 25,199,993 | [
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A universal electromagnetic energy conversion adapter based on a metamaterial absorber. | On the heels of metamaterial absorbers (MAs) which produce near perfect electromagnetic (EM) absorption and emission, we propose a universal electromagnetic energy conversion adapter (UEECA) based on MA. By choosing the appropriate energy converting sensors, the UEECA is able to achieve near 100% signal transfer ratio ... | 25,200,005 | [
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Are you talking to me? A possible role for γ-butyrolactones in interspecies signalling. | The secreted γ-butyrolactone signalling molecule SVB1 regulates the biosynthesis of jadomycin in Streptomyces venezuelae. Interestingly, this molecule is identical to SCB3, a secreted regulator of secondary metabolism in Streptomyces coelicolor. This is a departure for this class of signalling molecules as there are no... | 25,200,025 | [
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A novel miniaturized extraction capillary for determining gaseous formaldehyde by high-performance liquid chromatography. | A novel miniaturized sample extraction capillary was developed to provide a simple and sensitive method for analyzing gaseous formaldehyde (FA) using conventional high-performance liquid chromatography (HPLC). The extraction capillary was prepared by packing silica gel particles in a stainless steel capillary with a 1.... | 25,200,072 | [
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Direct binding of the Alu binding protein dimer SRP9/14 to 40S ribosomal subunits promotes stress granule formation and is regulated by Alu RNA. | Stress granules (SGs) are formed in response to stress, contain mRNAs, 40S ribosomal subunits, initiation factors, RNA-binding and signaling proteins, and promote cell survival. Our study describes a novel function of the protein heterodimer SRP9/14 and Alu RNA in SG formation and disassembly. In human cells, SRP9/14 e... | 25,200,073 | [
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Nosocomial extended-spectrum beta-lactamase-producing Klebsiella pneumoniae bacteremia in hemodialysis patients and the implications for antibiotic therapy. | In the face of increasing treatment options for extended-spectrum beta-lactamase-producing Klebsiella pneumoniae (ESBL-Kp) hemodialysis (HD) access-related bacteremia, the difference in clinical effectiveness between ertapenem and flomoxef remains unclear. We conducted this retrospective study to determine their effica... | 25,200,093 | [
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Cross-sectional study to assess the association of population density with predicted breast cancer risk. | The Gail and CARE models estimate breast cancer risk for white and African-American (AA) women, respectively. The aims of this study were to compare metropolitan and nonmetropolitan women with respect to predicted breast cancer risks based on known risk factors, and to determine if population density was an independent... | 25,200,109 | [
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Endocrinopathies, metabolic disorders, and iron overload in major and intermedia thalassemia: serum ferritin as diagnostic and predictive marker associated with liver and cardiac T2* MRI assessment. | Endocrinopathies and metabolic disorders-characterized β thalassemic (βT) patients and the prevention and treatment of these comorbidities are important targets to be achieved. The aim of the study was to analyze the diagnostic and prognostic role of ferritin for endocrinopathies and metabolic disorders in βT patients.... | 25,200,112 | [
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Perfusion culture-induced template-assisted assembling of cell-laden microcarriers is a promising route for fabricating macrotissues. | Mass transfer limitation in conventional top-down tissue engineering makes it impossible to fabricate large size viable tissue replacements. In the present study, we aimed at performing a systemic investigation of the assembling process in perfusion culture for fabricating centimeter-scale macrotissues from cell-laden ... | 25,200,115 | [
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CDKN2A mutations could influence the dermoscopic pattern of presentation of multiple primary melanoma: a clinical dermoscopic genetic study. | Patients who develop cutaneous melanoma are at increased risk of developing a second primary melanoma. There are many aetiological reasons by which the risk of a second melanoma increases. Among others, genetic factors may contribute to modulating this risk. The risk of identifying a CDKN2A germline mutation increases ... | 25,200,134 | [
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Erythropoietin protects red blood cells from TRAIL1-induced cell death during red blood cell transition in Xenopus laevis. | In anuran amphibians, larval red blood cells (RBCs) are replaced by adult-type RBCs during metamorphosis. We previously showed that tumor necrosis factor-related apoptosis-inducing ligand 1 (TRAIL1) induces apoptosis in larval-, but not adult-type RBCs in Xenopus laevis. We also found that protein kinase C (PKC) activa... | 25,200,139 | [
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[Ectopic expression of duck albumin down-regulates the expressions of IFN-β and myxovirus resistance 1 mRNA in DF-1 cells]. | To investigate the impact of duck albumin (ALB) gene on the mRNA expression levels of interferon β (IFN-β) and myxovirus resistance-1 (Mx1). The duck ALB gene was subcloned into pEGFP-C1 eukaryotic expression vector, and then the pEGFP-C1-ALB was transiently transfected into chick fibroblast DF-1 by Lipofectamine(TM) 2... | 25,200,153 | [
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[Construction and application of plasmid pVAX-HBVE harboring hepatitis B surface antibody targeted interferon and interleukin 12 genes]. | To construct a new gene therapy plasmid that can express both hepatitis B surface antibody(HBsAb) targeted interferon (dsFvα) and human interleukin 12 (hIL-12) genes for the immunotherapy of chronic hepatitis B. The pEE14.1-dsFvα plasmid was digested to obtain dsFvα fragment, and then the fragment was cloned into the u... | 25,200,154 | [
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[Effect of the targeted mutation of sorting motifs on the localization of porcine Ia-associated invariant chain]. | To investigate the effect of amino acids around two Leu-based motifs (Leu 7/Ile 8 and Met 16/Leu 17) in the cytosolic tail of porcine Ia-associated invariant chain (Ii) on endomembrane system positioning function. At first, two Leu-based motifs and amino acids around motifs were mutated through site-directed mutagenesi... | 25,200,155 | [
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[Over-expression of prohibitin gene promotes apoptosis in retinoic acid-resistant acute promyelocytic leukemia cell line NB4-R1]. | To construct a eukaryotic expression vector carrying human prohibitin gene and study the effect of prohibitin over-expression on the apoptosis of retinoic acid-resistant acute promyelocytic leukemia NB4-R1 cells. The prohibitin gene was amplified by PCR, and then cloned into pEGFP-N1-3FLAG eukaryotic expression vector.... | 25,200,157 | [
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[Establishment and evaluation of an in vitro method for neutrophil extracellular trap generation and degradation]. | To evaluate a novel method for in vitro generation and degradation of neutrophil extracellular traps (NETs), which are a newly recognized structure that is involved in the pathogenesis of autoimmune diseases and thrombosis. Neutrophils from peripheral blood of healthy donors were obtained by Ficoll-Histopaque gradient ... | 25,200,164 | [
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A Matter of Time: The Influence of Recording Context on EEG Spectral Power in Adolescents and Young Adults with ADHD. | Elevated theta or theta/beta ratio is often reported in attention deficit hyperactivity disorder (ADHD), but the consistency across studies and the relation to hypoarousal are increasingly questioned. Reports of elevated delta related to maturational lag and of attenuated beta activity are less well replicated. Some cr... | 25,200,165 | [
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Distractor removal amplifies spatial frequency-specific crossover of the attentional bias: a psychophysical and Monte Carlo simulation study. | Rarely noticed in daily life, attention may prefer the left side of space. Such attentional biases offer key insights into functions of spatial attention and visual awareness because they complement pathological biases in patients with spatial neglect who become largely unaware of the left side after right-brain damage... | 25,200,174 | [
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Contingency planning for electronic health record-based care continuity: a survey of recommended practices. | Reliable health information technology (HIT) in general, and electronic health record systems (EHRs) in particular are essential to a high-performing healthcare system. When the availability of EHRs are disrupted, alternative methods must be used to maintain the continuity of healthcare. We developed a survey to assess... | 25,200,197 | [
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0.12... |
Impact of selective fibronectin nanoconfinement on human dental pulp stem cells. | In this study, it was aimed to investigate the combinatory effect of biophysical and biochemical factors on human dental pulp stem cells' (hDPSCs) behavior. For this purpose, well-defined nanotopography of nanowells with two different pitch size of 109 nm and 341 nm were prepared on polyhydroxymethylsiloxane (PHMS) by ... | 25,200,204 | [
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0.1455879,
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Variation in patients' perceptions of elective percutaneous coronary intervention in stable coronary artery disease: cross sectional study. | To assess the perceptions of patients with stable coronary artery disease of the urgency and benefits of elective percutaneous coronary intervention and to examine how they vary across centers and by providers. Cross sectional study. 10 US academic and community hospitals performing percutaneous coronary interventions ... | 25,200,209 | [
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Families wish to retain links with trial during which their child died. | PARENTS WHOSE children die while taking part in a randomised controlled trial still wish to be kept in contact with the trial, a new study has found. | 25,200,223 | [
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Teenage cancer care model sets nursing competencies. | A NATIONAL framework for the nursing care of teenagers and young adults with cancer has been launched by the Teenage Cancer Trust. This is the first time a vision for the workforce has been set out. | 25,200,224 | [
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Light on specifics. | THE DRAFT Nursing and Midwifery Council (NMC) code of conduct sets out how nurses should behave and should be the document to inspire nurses towards excellence. In reality, it falls rather short of that and seems, at times, to be lengthy, repetitive, rather obscure, bland and agree to a low benchmark of performance. | 25,200,233 | [
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0.18639... |
Aneurysmal subarachnoid hemorrhage: a statewide assessment of outcome based on risk factors, aneurysm characteristics, and geo-demography. | Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating illness with nationwide mortality rates reaching almost 50% within the first 30 days. A study was undertaken to evaluate how treatment modality, physical findings, and geo-demography contribute to the outcome of these cases, including complications and disposit... | 25,200,246 | [
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0.5328194,
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Chagas disease awareness among Latin American immigrants living in Los Angeles, California. | Approximately 300,000 persons have Chagas disease in the United States, although almost all persons acquired the disease in Latin America. We examined awareness of Chagas disease among Latin American immigrants living in Los Angeles, California. We surveyed 2,677 persons (age range = 18-60 years) in Los Angeles who res... | 25,200,261 | [
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Short-term global health education programs abroad: disease patterns observed in Haitian migrant worker communities around La Romana, Dominican Republic. | The possibility of encountering rare tropical disease presentations is commonly described as a benefit derived by developed world medical trainees participating in clinical service-oriented short-term global health experiences in the developing world. This study describes the health status of a population served by a s... | 25,200,266 | [
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Lateral flow test using Echinococcus granulosus native antigen B and comparison of IgG and IgG4 dipsticks for detection of human cystic echinococcosis. | Cystic echinococcosis (CE) caused by infection with Echinococcus granulosus is of major concern for humans in many parts of the world. Antigen B was prepared from E. granulosus hydatid fluid, and Western blots confirmed eight batches showing a band corresponding to the 8-/12-kDa subunit with positive serum and no low-m... | 25,200,268 | [
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0.2821117,
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Neural regulation of pancreatic islet cell mass and function. | Intracellular glucose signalling pathways control the secretion of glucagon and insulin by pancreatic islet α- and β-cells, respectively. However, glucose also indirectly controls the secretion of these hormones through regulation of the autonomic nervous system that richly innervates this endocrine organ. Both parasym... | 25,200,301 | [
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0.1583536,
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Pharmacokinetics and pharmacodynamics of antiretrovirals in the central nervous system. | HIV-positive patients may be effectively treated with highly active antiretroviral therapy and such a strategy is associated with striking immune recovery and viral load reduction to very low levels. Despite undeniable results, the central nervous system (CNS) is commonly affected during the course of HIV infection, wi... | 25,200,312 | [
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Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas. | Studies in pediatric high-grade astrocytomas (HGA) by our group and others have uncovered recurrent somatic mutations affecting highly conserved residues in histone 3 (H3) variants. One of these mutations leads to analogous p.Lys27Met (K27M) mutations in both H3.3 and H3.1 variants, is associated with rapid fatal outco... | 25,200,321 | [
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0.07015798,
0.2447087,
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0.0255... |
Epidemiological burden of postmenopausal osteoporosis in Italy from 2010 to 2020: estimations from a disease model. | The article describes the adaptation of a model to estimate the burden of postmenopausal osteoporosis in women aged 50 years and over in Italy between 2010 and 2020. For this purpose, a validated postmenopausal osteoporosis disease model developed for Sweden was adapted to Italy. For each year of the study, the 'incide... | 25,200,337 | [
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... |
New terpenoid glycosides obtained from Rosmarinus officinalis L. aerial parts. | Five new terpenoid glycosides, named as officinoterpenosides A₁ (1), A₂ (2), B (3), C (4), and D (5), together with 11 known ones, (1S,4S,5S)-5-exo-hydrocamphor 5-O-β-D-glucopyranoside (6), isorosmanol (7), rosmanol (8), 7-methoxyrosmanol (9), epirosmanol (10), ursolic acid (11), micromeric acid (12), oleanolic acid (1... | 25,200,369 | [
0.01949754,
0.3835956,
0.124676,
0.1175695,
0.2071976,
0.04049595,
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0.4844787,
0.2937012,
-0.1532079,
0.1879286,
0.09756417,
-0.2433077,
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Changes in shear wave speed pre- and post-induction of labor: a feasibility study. | To explore the feasibility of using shear wave speed (SWS) estimates to detect differences in cervical softening pre- and post-ripening in women undergoing induction of labor. Subjects at 37-41 weeks' gestation undergoing cervical ripening before induction of labor were recruited (n = 20). Examinations, performed prior... | 25,200,374 | [
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0.4447455,
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0.04933349,
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A systematic approach for using DICOM structured reports in clinical processes: focus on breast cancer. | This paper describes a methodology for redesigning the clinical processes to manage diagnosis, follow-up, and response to treatment episodes of breast cancer. This methodology includes three fundamental elements: (1) identification of similar and contrasting cases that may be of clinical relevance based upon a target s... | 25,200,428 | [
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0.08634818,
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0.1174148,
0.05669381,
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Impact of reducing the threshold for acetylcysteine treatment in acute paracetamol poisoning: the recent United Kingdom experience. | On 3 September 2012, the licensed indication for acetylcysteine was changed in the United Kingdom (UK) so that all patients with a plasma paracetamol concentration above a "100 mg/L" (4 h post ingestion) nomogram treatment line after an acute paracetamol (acetaminophen) overdose should be treated. This is a lower thres... | 25,200,454 | [
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0.06469303,
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0.06301887,
0.1044858,
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0.08480424,
0.5502632,
0.1555701,
0.216907,
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0.4250834,
0.1659947,
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Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis. | Progesterone plays a protective role in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). Besides spinal cord neuropathology, MS patients present a dysfunctional hippocampus. In this work we studied the therapeutic effects of the progestin Nestorone in the brain of mice with chronic ... | 25,200,475 | [
0.2594492,
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0.205891,
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0.049975,
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0.114721,
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Co-localization of gluten consumption and HLA-DQ2 and -DQ8 genotypes, a clue to the history of celiac disease. | Celiac disease is an immune-mediated disorder triggered by gluten in genetically susceptible persons. Despite its detrimental effects on human health, it has not disappeared over time. The current evolutionary theory is that celiac disease is more common in areas reached later by agricultural revolution than in countri... | 25,200,477 | [
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0.08670321,
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0.551824,
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