title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Investigating long range correlation in DNA sequences using significance tests of conditional mutual information. | This study exploits the use of Markov chain order estimation from symbol sequences of systems exhibiting long memory or long range correlations (LRC), such as DNA sequences. In the presence of limited sequence length, LRC chain can be approximated by a high order Markov chain. For the order estimation, the parametric s... | 25,205,032 | [
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MTA1 regulates higher-order chromatin structure and histone H1-chromatin interaction in-vivo. | In the current study, for the first time, we found that metastasis-associated gene 1 (MTA1) was a higher-order chromatin structure organizer that decondenses the interphase chromatin and mitotic chromosomes. MTA1 interacts dynamically with nucleosomes during the cell cycle progression, prominently contributing to the m... | 25,205,035 | [
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Enhanced bioethanol production from yellow poplar by deacetylation and oxalic acid pretreatment without detoxification. | In order to produce ethanol from yellow poplar, deacetylation was performed using sodium hydroxide (NaOH). Optimal deacetylation conditions were determined by a response surface methodology. The highest acetic acid concentration obtained was 7.06 g/L when deacetylation was performed at 60 °C for 80 min with 0.8% NaOH. ... | 25,205,056 | [
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A novel synthetic route towards monodisperse β-NaYF4:Ln(3+) micro/nanocrystals from layered rare-earth hydroxides at ultra low temperature. | Monodisperse β-NaYF4:Ln(3+) (Ln = Yb/Er, Yb/Tm) single micro/nanocrystals were first one-pot fabricated at 50 °C through a novel synthetic route containing two pivotal processes: (a) synthesis of a β-NaYF4 {0001} unit layer through a novel style of ion-exchange from Y2(OH)5NO3·nH2O (LYH) and (b) the subsequent oriented... | 25,205,060 | [
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Study of cystoid macular edema by optical coherent tomography following uneventful cataract surgery. | The objective of this paper is to study the incidence of cystoid macular edema (CME) using optical coherence tomography (OCT) following uneventful small incision cataract surgery (SICS) and phacoemulsification. This was a descriptive, prospective study where 200 patients undergoing cataract surgery were randomly divide... | 25,205,061 | [
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A novel method for differentiation of human mesenchymal stem cells into smooth muscle-like cells on clinically deliverable thermally induced phase separation microspheres. | Muscle degeneration is a prevalent disease, particularly in aging societies where it has a huge impact on quality of life and incurs colossal health costs. Suitable donor sources of smooth muscle cells are limited and minimally invasive therapeutic approaches are sought that will augment muscle volume by delivering cel... | 25,205,072 | [
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Calcium-containing phosphopeptides pave the secretory pathway for efficient protein traffic and secretion in fungi. | Casein phosphopeptides (CPPs) containing chelated calcium drastically increase the secretion of extracellular homologous and heterologous proteins in filamentous fungi. Casein phosphopeptides released by digestion of alpha - and beta-casein are rich in phosphoserine residues (SerP). They stimulate enzyme secretion in t... | 25,205,075 | [
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Current approaches to the management of pediatric overweight and obesity. | Family-based behavioral intervention has been demonstrated to be an effective and safe treatment for childhood obesity and should be considered a first-line treatment option. However, access to such intensive evidence-based treatment is limited and, currently, obesity care is dominated by high intensity behavioral trea... | 25,205,083 | [
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Computational simulation of the mechanical response of brain tissue under blast loading. | In the present study, numerical simulations of nonlinear wave propagation and shock formation in brain tissue have been presented and a new mechanism of injury for blast-induced neurotrauma (BINT) is proposed. A quasilinear viscoelastic (QLV) constitutive material model was used that encompasses the nonlinearity as wel... | 25,205,088 | [
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A self-avoidance mechanism in patterning of the urinary collecting duct tree. | Glandular organs require the development of a correctly patterned epithelial tree. These arise by iterative branching: early branches have a stereotyped anatomy, while subsequent branching is more flexible, branches spacing out to avoid entanglement. Previous studies have suggested different genetic programs are respon... | 25,205,115 | [
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Epigenetics in the development, modification, and prevention of cardiovascular disease. | Epigenetics has major relevance to all disease processes; cardiovascular (CV) disease and its related conditions are no exception. Epigenetics is defined as the study of heritable alterations in gene expression, or cellular phenotype, and goes far beyond a pure genetic approach. A more precise definition is that epigen... | 25,205,125 | [
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Incretin-based drugs and the risk of congestive heart failure. | To determine whether the use of incretin-based drugs, including GLP-1 analogs and dipeptidyl peptidase-4 inhibitors, is associated with an increased risk of congestive heart failure (CHF) among patients with type 2 diabetes. The U.K. Clinical Practice Research Datalink, linked to the Hospital Episode Statistics databas... | 25,205,143 | [
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Variability in MRI vs. ultrasound measures of prostate volume and its impact on treatment recommendations for favorable-risk prostate cancer patients: a case series. | Prostate volume can affect whether patients qualify for brachytherapy (desired size ≥20 mL and ≤60 mL) and/or active surveillance (desired PSA density ≤0.15 for very low risk disease). This study examines variability in prostate volume measurements depending on imaging modality used (ultrasound versus MRI) and volume c... | 25,205,146 | [
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Increased cytogenetic abnormalities in exfoliated oral mucosal cells of South Indian foundry workers. | Biomonitoring offers a valuable tool to estimate the genetic risk as of exposure to genotoxic agents. Here, we intend to assess the potential cytogenetic damage related with occupational exposure to polycyclic aromatic hydrocarbons by evaluating the genetic damages in exfoliated buccal epithelial cells of foundry worke... | 25,205,155 | [
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Vesicular aptasensor for the detection of thrombin. | Self-assembled phospholipid vesicles are functionalized with thrombin-binding aptamers using a thiol-click reaction. The resulting aptasensors signal the binding of the analyte to the vesicle surface by changes of the emission properties of membrane co-embedded reporter dyes. | 25,205,174 | [
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[62-year old male patient with position-depending dyspnoe after hemipneumectomia]. | Dyspnoe is a symptom with a huge differential diagnostic spectrum. According to patients hemodynamic, acute forms can be caused by myocardial infarction, pulmonary embolism, pulmonary edema and heart rhythm disturbances while chronic forms can be caused by restrictive myocardial and pericardial diseases, hematooncologi... | 25,205,185 | [
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Synthesis and acetylcholinesterase inhibitory activity of Mannich base derivatives flavokawain B. | A novel series of flavokawain B derivatives, chalcone Mannich bases (4-10) were designed, synthesized, characterized, and evaluated for the inhibition activity against acetylcholinesterase (AChE). Biological results revealed that four compounds displayed potent activities against AChE with IC50 values below 20μM. Moreo... | 25,205,193 | [
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Involvement of major components from Sporothrix schenckii cell wall in the caspase-1 activation, nitric oxide and cytokines production during experimental sporotrichosis. | Sporotrichosis is a chronic infection caused by the dimorphic fungus Sporothrix schenckii, involving all layers of skin and the subcutaneous tissue. The role of innate immune toll-like receptors 2 and 4 in the defense against this fungus has been reported, but so far, there were no studies on the effect of cell wall ma... | 25,205,196 | [
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Deliveries of babies with normal health derived from oocytes with smooth endoplasmic reticulum clusters. | To examine the impact on development of derived embryos from smooth endoplasmic reticulum clusters (SERC) in human metaphase II (MII) oocytes. Retrospective analysis at Kyono ART Clinic. Comparison of embryological development, pregnancy, live birth and fetal malformation between oocytes with SERC (the SERC(+) group) a... | 25,205,205 | [
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Effects of edaravone, a radical scavenger, on hepatocyte transplantation. | Hepatocyte transplantation (HTx) has yielded significant improvements in liver function and survival in experimentally induced acute liver failure and liver-based metabolic disease. However, transplantation is inefficient, and it is thought that transplanted hepatocytes have a shortened lifespan because of inflammation... | 25,205,207 | [
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An analysis of violations of Osha's (1987) occupational exposure to benzene standard. | The Occupational Safety and Health Administration (OSHA), which was formed by the Occupational Safety and Health Act of 1970 (OSH Act), establishes enforceable health and safety standards in the workplace and issues violations and penalties for non-compliance with these standards. The purpose of the current study was t... | 25,205,215 | [
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Characterization of combinatorial histone modifications on lineage-affiliated genes during hematopoietic stem cell myeloid commitment. | Hematopoietic stem cells (HSCs) are multipotent stem cells capable of self-renewal and multilineage differentiation. Mechanisms regulating the maintenance of HSCs' multipotency and differentiation are still unclear. In this study, we observed the role of combinatorial histone modification pattern in the maintenance of ... | 25,205,219 | [
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Neonatal onset of leptin signalling in dopamine neurones of the ventral tegmental area in the rat. | Leptin inhibits feeding by acting on hypothalamic and mesolimbic dopamine (DA) pathways involved in the homeostatic and hedonic control of energy balance. In the rodent, the neonatal period is characterised by high circulating leptin concentrations and an insensitivity to the anorectic effects of this hormone, suggesti... | 25,205,242 | [
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Root canal preparation of mandibular molars with 3 nickel-titanium rotary instruments: a micro-computed tomographic study. | The aim of this study was to describe the canal shaping properties of ProTaper Next (PTN; Dentsply Maillefer, Ballaigues, Switzerland), ProTaper Universal (PTU; Dentsply Tulsa Dental Specialties, Johnson City, TN), and WaveOne (Dentsply Maillefer) nickel-titanium instruments in mandibular first molars by using micro-co... | 25,205,262 | [
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Economic crisis, immigrant women and changing availability of intimate partner violence services: a qualitative study of professionals' perceptions in Spain. | Since 2008, Spain has been in the throes of an economic crisis. This recession particularly affects the living conditions of vulnerable populations, and has also led to a reversal in social policies and a reduction in resources. In this context, the aim of this study was to explore intimate partner violence (IPV) servi... | 25,205,287 | [
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Interaction of omeprazole and Helicobacter pylori-induced nuclear factor-κB activation and mediators in gastric epithelial cells. | Omeprazole (OMP), a proton pump inhibitor, is a highly effective drug for the management of acid-related disorders. Infections resulting from cytotoxin antigen A (CagA) positive Helicobacter pylori strains have been associated with higher grades of gastric mucosal inflammation. Nuclear factor (NF)-κB activation has bee... | 25,205,289 | [
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Thermal niche evolution and geographical range expansion in a species complex of western Mediterranean diving beetles. | Species thermal requirements are one of the principal determinants of their ecology and biogeography, although our understanding of the interplay between these factors is limited by the paucity of integrative empirical studies. Here we use empirically collected thermal tolerance data in combination with molecular phylo... | 25,205,299 | [
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Dynamic variation in forebrain estradiol levels during song learning. | Estrogens shape brain circuits during development, and the capacity to synthesize estrogens locally has consequences for both sexual differentiation and the acute modulation of circuits during early learning. A recently optimized method to detect and quantify fluctuations in brain estrogens in vivo provides a direct me... | 25,205,304 | [
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0.08103068,
0.1038292,
0.1837565,
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0.2068696,
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-0.002923649,
0.2950048,
0.2607369,
-0.060517... |
Influence of heat and shear induced protein aggregation on the in vitro digestion rate of whey proteins. | Protein intake is essential for growth and repair of body cells, the normal functioning of muscles, and health related immune functions. Most food proteins are consumed after undergoing various degrees of processing. Changes in protein structure and assembly as a result of processing impact the digestibility of protein... | 25,205,335 | [
-0.0009579982,
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Neuroprotective agents target molecular mechanisms of disease in ALS. | Amyotrophic lateral sclerosis (ALS) is a debilitating disease characterized by progressive loss of voluntary motor neurons leading to muscle atrophy, weight loss and respiratory failure. Evidence suggests that inflammation, oxidative stress, mitochondrial dysfunction, apoptosis, glutamate excitotoxicity and proteasomal... | 25,205,348 | [
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How do environmental factors influence life cycles and development? An experimental framework for early-diverging metazoans. | Ecological developmental biology (eco-devo) explores the mechanistic relationships between the processes of individual development and environmental factors. Recent studies imply that some of these relationships have deep evolutionary origins, and may even pre-date the divergences of the simplest extant animals, includ... | 25,205,353 | [
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0.1... |
Application of human bone marrow-derived mesenchymal stem cells in the treatment of radiation-induced Gastrointestinal syndrome. | Nuclear accidents and terrorism present a serious threat for mass casualty. Accidental or intended radiation exposure leads to radiation-induced gastrointestinal (GI) syndrome. However, currently there are no approved medical countermeasures for GI syndrome. Thus, developing novel treatments for GI syndrome is urgent. ... | 25,205,377 | [
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0.0234126,... |
A systematic review of factors that act as barriers to patient referral to genetic services. | Patients who might benefit from genetic services may be denied access through failure to be referred. To investigate the evidence on barriers to referral to genetic services, we conducted a systematic review of empirical evidence on this topic. Nine studies were included in the review. Barriers related to non-genetic h... | 25,205,405 | [
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0.001182021,
0.1456995,
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Ultrasound-guided single-injection femoral nerve block provides effective analgesia after total knee arthroplasty up to 48 hours. | The purpose of this study is to evaluate the effects of ultrasound (US) guided single-injection femoral nerve block (FNB) spinal anesthesia on pain control, morphine consumption, adverse effects, and patient satisfaction during the postoperative 48-hour period in patients undergoing total knee arthroplasty (TKA). One h... | 25,205,409 | [
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[Changing trends and regional anesthesia practices in Turkey]. | Introduction of ultrasound into regional anesthesia (RA) practice has resulted in important changes and developments in RA. These developments have had a major influence on the way of practice and choice of blocks. The purpose of this study was to present the most recent instruments used in RA and clinical applications... | 25,205,412 | [
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[Who is responsible for the postoperative nerve injury? Anesthesia? Orthopedics? Trauma?]. | In the pathogenesis of peripheral nerve injury, mechanical as well as vascular pressure, and chemical reasons play a role. In the applications of peripheral nerve block, there can be mechanical injury due to the type of needle and intrafascicular injections. In humerus fractures, nerve injury can be seen due to the sur... | 25,205,414 | [
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0.1507495,
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Determinants of Pregnant Women's Online Self-Regulatory Activities for Appropriate Gestational Weight Gain. | This study examined psychosocial and sociodemographic factors associated with pregnant women's use of Web-based tools to set and monitor personal goals for healthy diet and physical activity. These tools were made available to women participating in a randomized trial testing a Web-based intervention to promote appropr... | 25,205,417 | [
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Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti-inflammatory agent. | Palmitoylethanolamide (PEA) acts via several targets, including cannabinoid CB1 and CB2 receptors, transient receptor potential vanilloid type-1 (TRPV1) ion channels, peroxisome proliferator-activated receptor alpha (PPAR α) and orphan G protein-coupled receptor 55 (GRR55), all involved in the control of intestinal inf... | 25,205,418 | [
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0.1211605,
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0.09176173,
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Investigation of desilylation in the recognition mechanism to fluoride by a 1,8-naphthalimide derivative. | A reaction-based chemosensor (AF-1) was designed, synthesized and applied as an optical approach for quantitative measurement of F(-) in MeCN. In the presence of F(-), selective fluoride-assisted desilylation instantly gave colorimetric and fluorogenic signals, providing a dual-optical channel for the detection of F(-)... | 25,205,438 | [
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0.1214351,
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Selective osteogenesis by a synthetic mineral inducing peptide for the treatment of osteoporosis. | Mineralization in mammalian cells is accomplished by concerted regulation of protein-based extracellular matrix (ECM) components, such as non-collagenous proteins and collagen fibrils. In this study, we investigated the ability of a collagen-binding motif (CBM) peptide derived from osteopontin to selectively affect ost... | 25,205,451 | [
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Catalytic asymmetric synthesis of alkynyl aziridines: both enantiomers of cis-aziridines from one enantiomer of the catalyst. | Alkynyl aziridines can be obtained from the catalytic asymmetric aziridination (AZ reaction) of alkynyl imines with diazo compounds in high yields and high asymmetric inductions mediated by a chiral boroxinate or BOROX catalyst. In contrast to the AZ reaction with aryl- and alkyl-substituted imines, alkynyl imines reac... | 25,205,455 | [
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Ki-1/57 and CGI-55 ectopic expression impact cellular pathways involved in proliferation and stress response regulation. | Ki-1/57 (HABP4) and CGI-55 (SERBP1) are regulatory proteins and paralogs with 40.7% amino acid sequence identity and 67.4% similarity. Functionally, they have been implicated in the regulation of gene expression on both the transcriptional and mRNA metabolism levels. A link with tumorigenesis is suggested, since both p... | 25,205,453 | [
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Mitochondrial pro-apoptotic indices do not precede the transient caspase activation associated with myogenesis. | Skeletal muscle differentiation requires activity of the apoptotic protease caspase-3. We attempted to identify the source of caspase activation in differentiating C2C12 skeletal myoblasts. In addition to caspase-3, caspase-2 was transiently activated during differentiation; however, no changes were observed in caspase... | 25,205,454 | [
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C4'/H4' selective, non-uniformly sampled 4D HC(P)CH experiment for sequential assignments of (13)C-labeled RNAs. | A through bond, C4'/H4' selective, "out and stay" type 4D HC(P)CH experiment is introduced which provides sequential connectivity via H4'(i)-C4'(i)-C4'(i-1)-H4'(i-1) correlations. The (31)P dimension (used in the conventional 3D HCP experiment) is replaced with evolution of better dispersed C4' dimension. The experimen... | 25,205,465 | [
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Albuminuria is associated with elevated acute phase reactants and proinflammatory markers in HIV-infected patients receiving suppressive combination antiretroviral therapy. | Albuminuria among HIV-infected individuals has been found to be associated with cardiovascular disease (CVD) and mortality. Inflammation has been associated with albuminuria. The pathophysiology of albuminuria in HIV-infected individuals is poorly understood. We investigated the association of albuminuria with inflamma... | 25,205,472 | [
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Family Functioning and Child Behavioral Problems in Households Affected by HIV and AIDS in Kenya. | HIV places acute stressors on affected children and families; especially in resource limited contexts like sub-Saharan Africa. Despite their importance, the epidemic's potential consequences for family dynamics and children's psychological health are understudied. Using a population-based sample of 2,487 caregivers and... | 25,205,474 | [
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Prediction of protein structural classes based on feature selection technique. | The prediction of protein structural classes is beneficial to understanding folding patterns, functions and interactions of proteins. In this study, we proposed a feature selection-based method to accurately predict protein structural classes. Three datasets with sequence identity lower than 25% were used to test the p... | 25,205,501 | [
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The effect of partial substitution of NaCl with KCl on the physicochemical, microbiological and sensory properties of Akkawi cheese. | Studies have shown a direct relationship between increased dietary sodium intake and chronic diseases such as hypertension, cardiovascular disease and osteoporosis. Potassium chloride is the most widely used salt substitute for sodium chloride in different processed foods. Akkawi cheese, commonly consumed as fresh chee... | 25,205,524 | [
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The optimal management of anti-thrombotic therapy after valve replacement: certainties and uncertainties. | Anti-thrombotic therapy after valve replacement encompasses a number of different situations. Long-term anticoagulation of mechanical prostheses uses vitamin K antagonists with a target international normalized ratio adapted to the characteristics of the prosthesis and the patient. The association of low-dose aspirin i... | 25,205,532 | [
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Active water transport in unicellular algae: where, why, and how. | The occurrence of active water transport (net transport against a free energy gradient) in photosynthetic organisms has been debated for several decades. Here, active water transport is considered in terms of its roles, where it is found, and the mechanisms by which it could occur. First there is a brief consideration ... | 25,205,578 | [
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Static autoregulation in humans: a review and reanalysis. | Cerebral autoregulation (CA) is a theoretical construct characterized by the relationship between mean arterial pressure (MAP) and cerebral blood flow (CBF). We performed a comprehensive literature search to provide an up-to-date review on the static relationship between MAP and CBF. The results are based on 40 studies... | 25,205,587 | [
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0.032988... |
Comparative analysis of bacterial community-metagenomics in coastal Gulf of Mexico sediment microcosms following exposure to Macondo oil (MC252). | The indigenous bacterial communities in sediment microcosms from Dauphin Island (DI), Petit Bois Island (PB) and Perdido Pass (PP) of the coastal Gulf of Mexico were compared following treatment with Macondo oil (MC252) using pyrosequencing and culture-based approaches. After quality-based trimming, 28,991 partial 16S ... | 25,205,599 | [
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Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes. | To evaluate the gene expression changes involved in neoplastic progression of cervical intraepithelial neoplasia. Using microarray analysis, large-scale gene expression profile was carried out on HPV16-CIN2, HPV16-CIN3, and normal cervical keratinocytes derived from two HPV16-CIN2, two HPV-CIN3 lesions, and two corresp... | 25,205,602 | [
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MLL partner genes in secondary acute lymphoblastic leukemia: report of a new partner PRRC1 and review of the literature. | Secondary acute lymphoblastic leukemia (sALL) following chemotherapy and/or radiotherapy of previous malignancies represents 2-10% of all cases of ALL. A 72-year-old female patient was diagnosed with acute lymphoblastic leukemia following chemotherapy for a diffuse large B cell lymphoma. Banding cytogenetics showed a t... | 25,205,603 | [
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The isomerization of allylrhodium intermediates in the rhodium-catalyzed nucleophilic allylation of cyclic imines. | Allylrhodium species generated from potassium allyltrifluoroborates can undergo isomerization by 1,4-rhodium(I) migration to give more complex isomers, which then react with cyclic imines to provide products with up to three new stereochemical elements. High enantioselectivities are obtained using chiral diene-rhodium ... | 25,205,604 | [
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0.04051398,
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0.06485882,
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The effects of medical marijuana laws on illegal marijuana use. | More and more states have passed laws that allow individuals to use marijuana for medical purposes. There is an ongoing, heated policy debate over whether these laws have increased marijuana use among non-patients. In this paper, I address that question empirically by studying marijuana possession arrests in cities fro... | 25,205,609 | [
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Weakness and fatigue in older ED patients in the United States. | The objectives of this study are to estimate the prevalence of weakness and fatigue visits in older emergency department (ED) patients, to compare demographics and resource use in these patients with those without these complaints, and to determine their ED diagnoses and disposition. We performed a cross-sectional coho... | 25,205,614 | [
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Comparison of diagnostic value of a novel noninvasive coronary computed tomography angiography method versus standard coronary angiography for assessing fractional flow reserve. | Noninvasive fractional flow reserve (FFR) from coronary computed tomography angiography (cCTA) correlates well with invasive FFR and substantially improves the detection of obstructive coronary artery disease. However, with current algorithms, computed tomography (CT)-based FFR is derived off-site in an involved time-c... | 25,205,628 | [
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Results of ventricular septal myectomy and hypertrophic cardiomyopathy (from Nationwide Inpatient Sample [1998-2010]). | Ventricular septal myomectomy (VSM) is the primary modality for left ventricular outflow tract gradient reduction in patients with obstructive hypertrophic cardiomyopathy with refractory symptoms. Comprehensive postprocedural data for VSM from a large multicenter registry are sparse. The primary objective of this study... | 25,205,630 | [
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Diagnosis and laryngeal complications of Bordatella pertussis infection in the ambulatory adult population. | Bordatella pertussis infection leads to a chronic, debilitating, and paroxysmal cough that can last for months to years. Incidence of B pertussis in the immunized adult population is rising nationwide, but many otolaryngologists are unfamiliar with the diagnosis and management of this disease. Adults often present late... | 25,205,637 | [
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Influence of COMT Genotype on Antero-posterior Cortical Functional Connectivity Underlying Interference Resolution. | Genetic variability related to the catechol-O-methyltransferase (COMT) gene (Val(158)Met) has received increasing attention as a possible modulator of executive functioning and its neural correlates. However, this attention has generally centered on the prefrontal cortices because of the well-known direct impact of COM... | 25,205,659 | [
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Asymptomatic Leishmania infections in northern India: a threat for the elimination programme? | Visceral leishmaniasis (VL) continues to embody as a mammoth public health problem and hurdle to the socioeconomic development of Bihar, India. Interestingly, all leishmanial infections do not lead to overt clinical disease and may stay asymptomatic for a period of time. Asymptomatic cases of VL are considered as proba... | 25,205,664 | [
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Top-down Modulation of Neural Activity in Anticipatory Visual Attention: Control Mechanisms Revealed by Simultaneous EEG-fMRI. | In covert visual attention, frontoparietal attention control areas are thought to issue signals to selectively bias sensory neurons to facilitate behaviorally relevant information and suppress distraction. We investigated the relationship between activity in attention control areas and attention-related modulation of p... | 25,205,663 | [
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Coding of stimulus strength via analog calcium signals in Purkinje cell dendrites of awake mice. | The climbing fiber input to Purkinje cells acts as a teaching signal by triggering a massive influx of dendritic calcium that marks the occurrence of instructive stimuli during cerebellar learning. Here, we challenge the view that these calcium spikes are all-or-none and only signal whether the instructive stimulus has... | 25,205,669 | [
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The adult ball-and-socket ankle joint: surgical management of late ankle and subtalar arthritis. | We review the surgical management of 4 adult patients with ball-and-socket ankle deformity who developed end-stage subtalar and/or ankle joint arthritis. We retrospectively reviewed a series of 4 adult patients with ball-and-socket ankle configurations who underwent surgical treatment for either end-stage tibiotalar or... | 25,205,679 | [
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Adenocarcinoma of the small bowel - a case report. | The paper presents a rare case of a patient with adenocarcinoma of the small intestine who reported to the hospital due to non-specific gastrointestinal symptoms. Following diagnostic examinations, the patient underwent a surgery. The post-operative period proceeded with no complications. The case presented below confi... | 25,205,699 | [
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Investigation of the mechanism of soft tissue conduction explains several perplexing auditory phenomena. | Soft tissue conduction (STC) is a recently expounded mode of auditory stimulation in which the clinical bone vibrator delivers auditory frequency vibratory stimuli to skin sites on the head, neck, and thorax. Investigation of the mechanism of STC stimulation has served as a platform for the elucidation of the mechanics... | 25,205,709 | [
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Cholesterol lowering: role in cancer prevention and treatment. | The accumulation of cholesterol is a general feature of cancer tissue, and recent evidence suggests that cholesterol plays critical roles in the progression of cancers, including breast, prostate, and colorectal cancers. The dysregulation of metabolic pathways, including those involved in cholesterol biosynthesis, is i... | 25,205,720 | [
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Drosophila FANCM helicase prevents spontaneous mitotic crossovers generated by the MUS81 and SLX1 nucleases. | Several helicases function during repair of double-strand breaks and handling of blocked or stalled replication forks to promote pathways that prevent formation of crossovers. Among these are the Bloom syndrome helicase BLM and the Fanconi anemia group M (FANCM) helicase. To better understand functions of these helicas... | 25,205,745 | [
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Do children make you happier? Sustained child-wish and mental health in women 11-17 years after fertility treatment. | Are fertility treatment-related factors, parenthood status and sustained child-wish associated with women's long-term mental health? Sustaining a child-wish is more strongly associated with women's long-term mental health than fertility treatment-related factors and parenthood status. About one-third of the couples sta... | 25,205,751 | [
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Autoantibodies against protein disulfide isomerase ER-60 are a diagnostic marker for low-grade testicular inflammation. | Is there a non-invasive biomarker for the diagnosis of testicular inflammatory lesions? In sera from infertile azoospermic patients with histologically confirmed low-grade testicular inflammation, significantly elevated titers of autoantibodies against disulfide isomerase family A, member 3 (ER-60) were found. Infectio... | 25,205,753 | [
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Social support mediates the association between benefit finding and quality of life in caregivers. | The psychosocial pathways underlying associations between benefit finding and quality of life are poorly understood. Here, we examined associations between benefit finding, social support, optimism and quality of life in a sample of 84 caregivers. Results revealed that quality of life was predicted by benefit finding, ... | 25,205,775 | [
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Extraskeletal chondroblastic osteosarcoma in the left atrium. | Primary cardiac extrasceletal osteosarcomas are uncommon tumours. They have aggressive behaviour and thus poor prognosis. This report describes a 40-year old female patient who was referred to our hospital with dyspnoea, weakness and syncopal attacks. Echocardiography and chest computed tomography showed a left atrial ... | 25,205,782 | [
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Integrating real-time clinical information to provide estimates of net clinical benefit of antithrombotic therapy for patients with atrial fibrillation. | Guidelines for anticoagulant therapy in patients with atrial fibrillation are based on stroke risk as calculated by either the CHADS2 or the CHA2DS2VASc scores and do not integrate bleeding risk in an explicit, quantitative manner. Our objective was to quantify the net clinical benefit resulting from improved decision ... | 25,205,788 | [
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Associations between anticoagulation therapy and risks of mortality and readmission among patients with heart failure and atrial fibrillation. | Patients with heart failure and atrial fibrillation are at higher risk of thromboembolic events than patients with heart failure alone. Yet, the use of anticoagulation therapy varies in clinical practice, especially among older patients, for whom its effectiveness is poorly understood. Using clinical registry data link... | 25,205,789 | [
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Quality of life among adults with epidermolysis bullosa living with a gastrostomy tube since childhood. | Epidermolysis bullosa (EB) is a rare genetic condition characterized by blistering to the skin and internal mucous membranes arising from mild mechanical trauma. The impact on those affected can be significant. They might have increased nutritional requirements because of blistering, chronic wounds, infection, and loss... | 25,205,791 | [
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β-adrenergic receptor-mediated cardiac contractility is inhibited via vasopressin type 1A-receptor-dependent signaling. | Enhanced arginine vasopressin levels are associated with increased mortality during end-stage human heart failure, and cardiac arginine vasopressin type 1A receptor (V1AR) expression becomes increased. Additionally, mice with cardiac-restricted V1AR overexpression develop cardiomyopathy and decreased β-adrenergic recep... | 25,205,804 | [
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A prospective study of height and body mass index in childhood, birth weight, and risk of adult glioma over 40 years of follow-up. | Greater attained height and greater body mass index (BMI; weight (kg)/height (m)(2)) in young adulthood have been associated with glioma risk, but few studies have investigated the association with body size at birth or during childhood, when the brain undergoes rapid cell growth and differentiation. The Copenhagen Sch... | 25,205,831 | [
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Overexpression of HtrA1 and exposure to mainstream cigarette smoke leads to choroidal neovascularization and subretinal deposits in aged mice. | We determined the function of ARMS2 and HtrA1 in the choroid and retina using transgenic (Tg) mice and evaluated the effects of mainstream cigarette smoke on these mice. The chicken actin promoter (CAG) was used to drive mouse HtrA1, human ARMS2, and ARMS2 (A69S) expression in the entire body of a mouse for one year. F... | 25,205,867 | [
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CNGB3-achromatopsia clinical trial with CNTF: diminished rod pathway responses with no evidence of improvement in cone function. | Ciliary neurotrophic factor (CNTF) protects rod photoreceptors from retinal degenerative disease in multiple nonhuman models. Thus far, CNTF has failed to demonstrate rod protection in trials for human retinitis pigmentosa. Recently, CNTF was found to improve cone photoreceptor function in a canine CNGB3 achromatopsia ... | 25,205,868 | [
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Primary Sjogren's syndrome presenting as Acute Flaccid Quadriplegia:. | Primary Sjogren's Syndrome presenting as quadriplegia and respiratory involvement due to renal tubular acidosis causing hypokalemia is rare and the significance of managing such case with potassium citrate instead of potassium chloride is highlighted. | 25,205,881 | [
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In Vivo application of RNAi to study pain. | Chronic pain is associated with several disease conditions. The inadequacy of current analgesics to treat chronic pain is the result of a lack of understanding of the mechanisms that mediate pain. RNA interference has emerged in recent years as a new way to evaluate the roles of molecules involved in the pain response.... | 25,205,892 | [
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Desferioximine induced Ototoxicity in Thalassemic patients. | Thalassemia is a hereditary disorder requiring regular blood transfusion. To determine hearing sensitivity in transfusion-dependent thalassemics who were receiving desferioximine and on oral iron chelation (desferioximine) therapy. 26 patients with B-thelassemia in the age range of 5-22 years were enrolled in the thala... | 25,205,902 | [
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0.09378146,
0.8136492,
0.06382197,
0.02710274,
-0.374114,
-0.312102,
-0.01901659,
0.04161635,
-0.6805705,
0.02540159,
0.004014322,
0.2331708,
0.1386246... |
Behavioral analysis after sciatic nerve compression in albino rats. | Walking track analysis which has been widely used to examine the recovery of gait functions in rats with sciatic nerve injury. The present study was aimed to objectively analyze and quantify the degree of functional recovery in locomotor behavior of rats after inflicting sciatic nerve crush injury. Wistar rats trained ... | 25,205,919 | [
0.09156142,
0.2338371,
-0.2310565,
-0.2523502,
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-0.2289624,
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0.05190809,
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0.2320052,
0.3336366,
... |
Emerging role of WNK1 in pathologic central nervous system signaling. | WNK1 (with no lysine (K)) is a widely expressed serine/threonine protein kinase. The role of this kinase was first described in the kidney where it dynamically controls ion channels that regulate changes in cell volume. WNK1, through intermediates oxidative stress-responsive kinase-1 (OSR1) and STE20/SPS1-related proli... | 25,205,925 | [
-0.1346321,
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0.02782798,
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0.1972788,
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0.2528569,
0.1365761,
-0.2568251,
-0.1638402,
0.2748252,
0.0926107... |
The multifunctional and multi-system influence of Ghrelin in the treatment of diabetic and spinal cord injury induced Neuropathy. | Ghrelin (Gh), a small peptide, which was originally discovered as a gastrointestinal (GI) tropic hormone, has shown to have a presence and function within multiple tissue systems. Recently, Gh has shown to exhibit anti-inflammatory and regenerative abilities in response to both chemical and mechanical stressors within ... | 25,205,937 | [
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0.004903112,
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0.1079388,
0.05918517,
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0.1486644,
-0.0908478... |
Molecular interaction of Survivin and Piperine by computational docking analyses for neuroblastoma targeting. | Neuroblastoma (NB) is a childhood cancer causing significant mortality in at least 1% children worldwide. NB is an embryonically derived tumor. The causative agents include genetic predisposition and dysregulated signaling cascades. Survivin is an important anti-apoptotic protein that is significantly up-regulated in N... | 25,205,944 | [
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0.427399,
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Development of time-resolved fluorescent based [EU]-GTP binding assay for selection of human Histamine 3 receptor antagonists/inverse agonist: a potential target for Alzheimer's treatment. | The histamine H3 receptor is an attractive G protein-coupled receptor drug target that regulates neurotransmission in the central nervous system and plays a crucial role in cognitive and homeostatic functions. This receptor exhibits molecular, pharmacological, and functional heterogeneity that affects the preclinical d... | 25,205,969 | [
0.281608,
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0.4622853,
0.3269529,
0.2362035,
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Young girl with multiple intracranial hydatid cyst. | 8 years young girl presented with uncontrolled seizures in obtunded and bedridden state. MRI brain showed multiple extra-axial coalescent cystic lesions in bilateral frontotemporo parietal regions - diagnosed as multiple hydatid cyst. We used irrigation saline during surgery and a total 35 cysts were removed intact, on... | 25,205,976 | [
-0.1957871,
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0.002181429,
0.1115576,
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0.1133165,
-0.004514796,... |
Ramped-rate vs continuous-rate infusions: An in vitro comparison of convection enhanced delivery protocols. | Convection enhanced delivery (CED) is a technique using infusion convection currents to deliver therapeutic agents into targeted regions of the brain. Recently, CED is gaining significant acceptance for use in gene therapy of Parkinson's disease (PD) employing direct infusion into the brain. CED offers advantages in th... | 25,206,014 | [
-0.09852438,
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0.04915474,
0.2383652,
0.2700176,
0.1580477,
0.2338547,
... |
Convection Enhanced Delivery: A Comparison of infusion characteristics in ex vivo and in vivo non-human primate brain tissue. | Convection enhanced delivery (CED) is emerging as a promising infusion toolto facilitate delivery of therapeutic agents into the brain via mechanically controlled pumps. Infusion protocols and catheter design have an important impact on delivery. CED is a valid alternative for systemic administration of agents in clini... | 25,206,026 | [
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0.03251637,
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0.2255797,
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0.3509157,
-0.06818... |
Comparison of neurophysiological and MRI findings of patients with multiple sclerosis using oligoclonal band technique. | The correlation of oligoclonal bands (OCBs) and intrathecal IgG synthesis are not yet clear in multiple sclerosis (MS). In this study, we investigated the OCB situation and IgG index, cranial and cervical magnetic resonance imaging (MRI) findings and also compared visual evoked potentials (VEP) and somatosensorial evok... | 25,206,039 | [
0.1577868,
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0.1047577,
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0.4463252,
0.1156402,
-... |
Glutamate gated spiking Neuron Model. | Biological neuron models mainly analyze the behavior of neural networks. Neurons are described in terms of firing rates viz an analog signal. The Izhikevich neuron model is an efficient, powerful model of spiking neuron. This model is a reduction of Hodgkin-Huxley model to a two variable system and is capable of produc... | 25,206,048 | [
0.01676243,
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0.0686422,
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0.1727827,
0.04419185,
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0.1880183,
0.2811957,
0.2318416,... |
Atropine poisoning mimicking septicemia. | A young female was admitted in medical emergency room with fever, tachycardia and breathing difficulty. A provisional diagnosis of septicemia was made and empirical antibiotics were started. The patient required intubation and assisted ventilation. The patient recovered within 72 hours completely except bilateral mid-d... | 25,206,054 | [
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0.2446635,
-0.08151962,
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-0.0757661,
-0.1318103,
-0.066529... |
Endo-esthetic Management of Permanent Maxillary Lateral Incisor with Severe Root Dilaceration in a 12-year-old Child. | Functional, esthetic and endodontic restoration of a pulpally involved permanent incisor with root dilaceration often presents a daunting clinical challenge. The outcome of conventional treatment modalities like surgical removal of the tooth followed by orthodontic closure of the space is time consuming and estheticall... | 25,206,086 | [
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0.5896235,
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0.363113,
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0.2363158,
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0.2414211,
-0.3874935,
-0.407726,
0.2729126,
0.3258225,
-0.0957685,
0... |
A comparative evaluation of hydroxyapatite crystals and glutaraldehyde as agents for pulpotomy in deciduous molars. | To evaluate and compare clinically and radiographically use of hydroxyapatite crystals and 2% glutaraldehyde as a pulpotomy agent. Thirty deciduous molars were treated with pulpotomy using hydroxyapatite crystals and 2% glutaraldehyde. Clinical and radiographic findings were observed at three months and six months. The... | 25,206,093 | [
0.1998008,
0.390256,
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0.111505,
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0.3052539,
0.2798268,
0.09039506,
... |
Recurrent unicystic ameloblastoma of the infratemporal and temporal fossa. | The ameloblastoma has been described as benign but locally invasive; benign and locally invasive with strong tendency to recur; and locally malignant. Recurrence of this lesion in to the infratemporal and temporal region are rarely reported cases. Complete excision of lesion was done with the help of the advance imagin... | 25,206,097 | [
-0.3278331,
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0.148339,
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0.336297,
0.05052816,
0.046428... |
Langerhans cell histiocytosis of maxilla and mandible in 6 years old child: a case report. | Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the proliferation of specialized bone marrow-derived Langerhans cells (LCs) and mature eosinophils. Its etiology is unknown but it could be due to antigenic stimulus of an infectious, genetic abnormality, deregulated immune response... | 25,206,111 | [
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0.2693914,
0.2151621,
0.2555125,
0.102622,
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... |
Evaluation and comparison of biological cleaning efficacy of two endofiles and irrigants as judged by microbial quantification in primary teeth - an in vivo study. | The endodontic triad comprises of cleaning and shaping, disinfection and obturation. Success of root canal therapy is majorly achieved by proper cleaning and shaping. However, elimination of bacterial contaminants as well as necrotic debris of the canals requires the adjunctive use of irrigants. To achieve a satisfacto... | 25,206,117 | [
-0.05074225,
0.602819,
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0.2633336,
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0.08780024,
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0.534026,
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-0.09339172,
0.1342846,
0.3429336,
0.02595991,
... |
Replantation of immature avulsed teeth with prolonged extraoral dry storage: a case report. | This case report presents delayed replantation of avulsed teeth after extended extraoral period and nonphysiological storage. Yet, long-term prognosis is not good, it presents alternate treatment modality to immediately restore esthetic and function as well as to promote the growth of alveolar crest for proper eruption... | 25,206,138 | [
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-0.03965364,
-0.249061,
-0.02553806,
0.1494404,
-0.016680... |
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