title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Synthesis and characterization of self-curing hydrophilic bone cements for protein delivery. | New formulations of acrylic bone cements for bone defect reparation, based on self-hardening methyl methacrylate (MMA)/methacrylic acid (MAA), with a high capacity for protein delivery, have been developed. The self-curing formulations were prepared by partial substitution of solid phase PMMA microparticles by newly ob... | 25,209,322 | [
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Compound heterozygous PLEC mutations in a patient of consanguineous parentage with epidermolysis bullosa simplex with muscular dystrophy and diffuse alopecia. | Epidermolysis bullosa simplex with muscular dystrophy (EBS-MD; OMIM 226670) is an autosomal recessive form of EBS, characterized by skin blistering at birth and delayed onset of muscle dystrophy. Mutations in PLEC, the gene encoding plectin, have been identified to be causal for EBS-MD. We report a case of EBS-MD with ... | 25,209,331 | [
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Cranial morphological diversity of early, middle, and late Holocene Brazilian groups: implications for human dispersion in Brazil. | The history of human occupation in Brazil dates to at least 14 kyr BP, and the country has the largest record of early human remains from the continent. Despite the importance and richness of Brazilian human skeletal collections, the biological relationships between groups and their implications for knowledge about hum... | 25,209,335 | [
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"Sliding angulation osteotomy": preliminary report of a novel technique of treatment for chronic radial head dislocation following missed Monteggia injuries. | Neglected anterior radial head dislocation in type I Monteggia lesions leads to restriction of movement, deformity and instability of the affected elbow. If left untreated this leads to a painful arthritic elbow due to secondary degenerative changes. This is a difficult problem to manage and many intra-articular, extra... | 25,209,346 | [
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Cornelia de Lange syndrome. | Cornelia de Lange syndrome (CdLS; MIM #122470, 300590, 610759, 614701, 300882) is a rare and clinically variable disorder that affects multiple organs. It is characterized by intellectual disability (mild to severe), distinctive facial features, prenatal and postnatal growth retardation, and hirsutism. Congenital anoma... | 25,209,348 | [
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Potentially functional polymorphisms in the ERCC2 gene and risk of esophageal squamous cell carcinoma in Chinese populations. | ERCC2 is indispensable for nucleotide excision repair pathway, and its functional polymorphisms may be associated with cancer risk. In a large case-control study of 1126 esophageal squamous cell carcinomas (ESCC) patients and 1131 controls, we genotyped two SNPs in ERCC2 (rs238406 G > T and rs13181 T > G) and ass... | 25,209,371 | [
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Concurrent and longitudinal relationships between cognitive activity, cognitive performance, and brain volume in older adult women. | We investigated (a) cross-sectional associations between cognitive activity, cognitive performance, and MRI measures and (b) longitudinal associations between cognitive activity and change in cognitive performance, using structural equation modeling (SEM). Women's Health Initiative Memory Study (WHIMS) Extension partic... | 25,209,372 | [
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Submandibular artery: bilobed platysma myocutaneous flap for total lower lip reconstruction. | Lower lip reconstruction following cancer resection includes a variety of clinical and microsurgical options. We have developed a myocutaneous flap for full thickness reconstruction with a functioning muscle. In all patients, the submandibular artery was outlined using computerized tomographic angiography and Doppler. ... | 25,209,383 | [
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Effects of metabolic acidosis on intracellular pH responses in multiple cell types. | Metabolic acidosis (MAc), a decrease in extracellular pH (pHo) caused by a decrease in [HCO3 (-)]o at a fixed [CO2]o, is a common clinical condition and causes intracellular pH (pHi) to fall. Although previous work has suggested that MAc-induced decreases in pHi (ΔpHi) differ among cell types, what is not clear is the ... | 25,209,413 | [
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Obesity-stroke paradox and initial neurological severity. | An obesity paradox in patients with stroke has been documented. However, although the initial neurological severity (INS) is generally the most important prognostic factor, the impact of this paradox has not been considered in most previous studies. We sought to investigate the impact of obesity on INS in patients with... | 25,209,415 | [
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Optimal design of clinical trials with biologics using dose-time-response models. | Biologics, in particular monoclonal antibodies, are important therapies in serious diseases such as cancer, psoriasis, multiple sclerosis, or rheumatoid arthritis. While most conventional drugs are given daily, the effect of monoclonal antibodies often lasts for months, and hence, these biologics require less frequent ... | 25,209,423 | [
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Bone's responses to different designs of implant-supported fixed partial dentures. | This paper explores the biomechanics and associated bone remodeling responses of two different abutment configurations, namely implant-implant-supported versus tooth-implant-supported fixed partial dentures. Two 3D finite element analysis models are created based upon computerized tomography data. The strain energy den... | 25,209,424 | [
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Emotional assessment of patients with oral lichen planus. | Oral lichen planus is a chronic immune-mediated disease with an estimated prevalence of 0.5-2.5% in the general population. Patients with oral lichen planus are often emotionally unstable and anxious and may develop concomitant systemic disorders. The objective of this study was to evaluate emotional characteristics of... | 25,209,436 | [
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How Can Adult Children Influence Parents' Long-Term Care Insurance Purchase Decisions? | Long-term care (LTC) poses a significant strain on public health insurance financing. In response, there is policy interest in bolstering the private long-term care insurance (LTCI) market. Although families are central to LTC provision, their role in LTCI demand remains unclear. The purpose of this study was to obtain... | 25,209,446 | [
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Trends of pre-hospital emergency medical services activity over 10 years: a population-based registry analysis. | The number of requests to pre-hospital emergency medical services (PEMS) has increased in Europe over the last 20 years, but epidemiology of PEMS interventions has little be investigated. The aim of this analysis was to describe time trends of PEMS activity in a region of western Switzerland. Use of data routinely and ... | 25,209,450 | [
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Hydroa vacciniforme with eye involvement: report of two cases. | We herein report two patients with hydroa vacciniforme and concomitant ophthalmic involvement, primarily in the form of keratoconjunctivitis leading to corneal opacity. Awareness of this occasional manifestation may help to prevent severe complications. | 25,209,448 | [
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Understanding Positive Play: An Exploration of Playing Experiences and Responsible Gambling Practices. | This study is one of the first to explore in detail the behaviors, attitudes and motivations of players that show no signs of at-risk or problem gambling behavior (so-called 'positive players'). Via an online survey, 1484 positive players were compared with 209 problem players identified using the Lie/Bet screen. The s... | 25,209,455 | [
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International standards for newborn weight, length, and head circumference by gestational age and sex: the Newborn Cross-Sectional Study of the INTERGROWTH-21st Project. | In 2006, WHO published international growth standards for children younger than 5 years, which are now accepted worldwide. In the INTERGROWTH-21(st) Project, our aim was to complement them by developing international standards for fetuses, newborn infants, and the postnatal growth period of preterm infants. INTERGROWTH... | 25,209,487 | [
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International standards for fetal growth based on serial ultrasound measurements: the Fetal Growth Longitudinal Study of the INTERGROWTH-21st Project. | In 2006, WHO produced international growth standards for infants and children up to age 5 years on the basis of recommendations from a WHO expert committee. Using the same methods and conceptual approach, the Fetal Growth Longitudinal Study (FGLS), part of the INTERGROWTH-21(st) Project, aimed to develop international ... | 25,209,488 | [
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Syntheses and biological activities of the proposed structure of apteniol A and its derivatives. | We describe the syntheses of the proposed structure of diphenyl ether oxyneolignan, apteniol A and its derivatives. The diphenyl ether moiety of proposed apteniol A was formed via Ullmann ether synthesis, but the spectral data of the synthesized apteniol A did not agree with that in previous studies. The dimethyl ester... | 25,209,495 | [
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Determination of hydrophobicity of dry-heated wheat starch granules using sucrose fatty acid esters (SFAE). | Sucrose fatty acid esters (SFAE) were adsorbed onto dry-heated (120 °C for 10, 20, 40, 60, and 120 min) wheat starch granules and extracted with ethyl ether in a Soxhlet apparatus without gelatinization of the starch granules. The amount of sucrose in the extracted SFAE was determined by the phenol sulfate method. A gr... | 25,209,506 | [
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You didn't have to do that: belief in free will promotes gratitude. | Four studies tested the hypothesis that a weaker belief in free will would be related to feeling less gratitude. In Studies 1a and 1b, a trait measure of free will belief was positively correlated with a measure of dispositional gratitude. In Study 2, participants whose free will belief was weakened (vs. unchanged or b... | 25,209,516 | [
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Viewpoint: Re-instating a 'public health' system under universal health care in India. | I examine possibilities for strengthening essential public health functions in the context of India's drive to implement universal health care. In a country where population health outcomes are rooted in social, political, economic, cultural, and ecological conditions, it is important to have a state mediated public he... | 25,209,538 | [
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Phytodiversity on fly ash deposits: evaluation of naturally colonized species for sustainable phytorestoration. | Proliferation of fly ash (FA) deposits and its toxicity have become a global concern, which contaminate the ecosystems of our Earth. In this regard, identification of potential plant species for FA deposits' restoration is the main concern. Keeping this view in mind, the present study was conducted to identify potentia... | 25,209,541 | [
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Two novel zeolitic imidazolate frameworks (ZIFs) as sorbents for solid-phase extraction (SPE) of polycyclic aromatic hydrocarbons (PAHs) in environmental water samples. | In this work, two novel zeolitic imidazolate framework (ZIF) materials, ZIF-7 and ZIF-11, were firstly introduced as solid-phase extraction (SPE) sorbents for PAHs efficient extraction and highly sensitive analysis in environmental water samples with high performance liquid chromatography (HPLC) coupled with fluorescen... | 25,209,546 | [
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Thermodynamics of water condensation on a primary marine aerosol coated by surfactant organic molecules. | A large subset of primary marine aerosols can be initially (immediately upon formation) treated using an "inverted micelle" model. We study the thermodynamics of heterogeneous water condensation on such a marine aerosol. Its hydrophobic organic coating can be processed by chemical reactions with atmospheric species; th... | 25,209,578 | [
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Multiple sclerosis in Germany: data analysis of administrative prevalence and healthcare delivery in the statutory health system. | Healthcare-utilization data for multiple sclerosis (MS) are scarce in Germany. The Purpose of the study was to analyse administrative prevalence of MS, medication use and type of specialists involved in MS treatment in the outpatient setting in Bavaria. Pseudonymized claims data from Bavarian Statutory Health Insurance... | 25,209,585 | [
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Long-term Outcome of Peripherally Implanted Venous Access Ports in the Forearm in Female Cancer Patients. | The aim of this retrospective study was to analyze the long-term outcome of peripherally implanted venous access ports in the forearm at our institution in a female patient collective. Between June 2002 and May 2011, a total of 293 female patients with an underlying malignancy had 299 forearm ports implanted in our int... | 25,209,595 | [
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The risk for depression in patients with ankylosing spondylitis: a population-based cohort study. | Depression is frequent in ankylosing spondylitis (AS) patients. However, epidemiological data about the potential increase in risk are lacking. This study compares the rate of doctor-diagnosed depression in a well defined cohort of AS patients to the general population seeking care. The Skåne Healthcare Register compri... | 25,209,603 | [
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Predicting the Time Course of Individual Objects with MEG. | To respond appropriately to objects, we must process visual inputs rapidly and assign them meaning. This involves highly dynamic, interactive neural processes through which information accumulates and cognitive operations are resolved across multiple time scales. However, there is currently no model of object recogniti... | 25,209,607 | [
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Influence of ofloxacin on photosystems I and II activities of Microcystis aeruginosa and the potential role of cyclic electron flow. | Pollution with antibiotics poses a great risk to aquatic ecosystems. Although some toxic effects of antibiotics on photosystem II (PSII) have been documented, their toxicity to photosystem I (PSI) is still unclear. In this study, effects of ofloxacin on activities of both PSI and PSII of Microcystis aeruginosa (Kützing... | 25,209,631 | [
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Global burden of dental condition among children in nine countries participating in an international oral health promotion programme, 2012-2013. | The Live.Learn.Laugh. phase 2 programme is a unique global partnership between FDI World Dental Federation and Unilever Oral Care which aims to provide measurable improvement of oral health on a global scale through encouraging twice-daily brushing with a fluoride toothpaste. It was based on international recommendatio... | 25,209,648 | [
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Immune functions of platelets. | This review collects evidence about immune and inflammatory functions of platelets from a clinician's point of view. A focus on clinically relevant immune functions aims at stimulating further research, because the complexity of platelet immunity is incompletely understood and not yet translated into patient care. Plat... | 25,209,670 | [
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Alpha-synuclein binds to the inner membrane of mitochondria in an α-helical conformation. | The human alpha-Synuclein (αS) protein is of significant interest because of its association with Parkinson's disease and related neurodegenerative disorders. The intrinsically disordered protein (140 amino acids) is characterized by the absence of a well-defined structure in solution. It displays remarkable conformati... | 25,209,675 | [
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The Utility of the WHO ICD-10-AM Pastoral Intervention Codings Within Religious, Pastoral and Spiritual Care Research. | The World Health Organization (WHO) 'Pastoral Intervention Codings' were first released in 2002 as part of the 'International Statistical Classification of Diseases and Related Health Problems' (WHO 2002). The purpose of the WHO pastoral intervention codings (colloquially abbreviated as 'WHO-PICs') was to record and ac... | 25,209,684 | [
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Individual phenolic response and peroxidase activity in peel of differently sun-exposed apples in the period favorable for sunburn occurrence. | Extreme weather events like high solar radiation can cause stress in apple fruits (Malus domestica Borkh.). The aim of the study was to make a screening of individual phenols and peroxidase activity in apple peel as a response to sunburn and different sun-exposures in the period when weather conditions are suitable for... | 25,209,696 | [
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Pustular secondary syphilis: report of three cases and review of the literature. | Pustular syphilis is an extremely rare manifestation of secondary syphilis. Failure to recognize the disease can have devastating consequences. We present three patients with pustular syphilis as the primary manifestation of secondary syphilis. Patient 1 was initially diagnosed by Venereal Disease Research Laboratory (... | 25,209,699 | [
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Context-dependent latent inhibition in preweanling rats. | Preexposure to a conditioned stimulus (CS) usually weakens conditioning, an effect known as latent inhibition. Similar to other learning interference effects, latent inhibition has been characterized as context-dependent, which means that the magnitude of this effect can be attenuated by changing the context between th... | 25,209,712 | [
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Extremely 'vanadiphilic' multiply metal-resistant and halophilic aerobic anoxygenic phototrophs, strains EG13 and EG8, from hypersaline springs in Canada. | Two pinkish peach-colored strains of obligately aerobic phototrophic bacteria, EG13 and EG8, were isolated from a saline spring effluent stream in west central Manitoba, Canada. The strains possessed bacteriochlorophyll a incorporated into a typical purple bacterial light-harvesting complex 1 (870 nm) and reaction cent... | 25,209,747 | [
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Mechanisms of nanosized titanium dioxide-induced testicular oxidative stress and apoptosis in male mice. | Due to the increased application of titanium dioxide nanoparticles (TiO₂ NPs) in the food industry and daily life, their potential toxic effects in humans and animals have been investigated. However, very few studies have focused on testicular oxidative stress and/or apoptosis. In order to understand the possible molec... | 25,209,749 | [
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Identification of an antigenic domain in the N-terminal region of avian hepatitis E virus (HEV) capsid protein that is not common to swine and human HEVs. | The antigenic domains located in the C-terminal 268 amino acid residues of avian hepatitis E virus (HEV) capsid protein have been characterized. This region shares common epitopes with swine and human HEVs. However, epitopes in the N-terminal 338 amino acid residues have never been reported. In this study, an antigenic... | 25,209,807 | [
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Paramyxovirus-based production of Rift Valley fever virus replicon particles. | Replicon-particle-based vaccines combine the efficacy of live-attenuated vaccines with the safety of inactivated or subunit vaccines. Recently, we developed Rift Valley fever virus (RVFV) replicon particles, also known as nonspreading RVFV (NSR), and demonstrated that a single vaccination with these particles can confe... | 25,209,808 | [
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[CLOVES syndrome: a malformational syndrome closely resembling Proteus syndrome]. | CLOVES syndrome (Congenital Lipomatous asymmetric Overgrowth of the trunk with lymphatic, capillary, venous, and combined-type Vascular malformations, Epidermal nevi, Skeletal anomalies) is a sporadic malformational syndrome that has recently been described (mutation of PIK3CA), with asymmetric body hypertrophy, lipoma... | 25,209,813 | [
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An Outbreak of Porcine Reproductive and Respiratory Syndrome Virus in Switzerland Following Import of Boar Semen. | An outbreak of porcine reproductive and respiratory syndrome virus (PRRSV) occurred in November 2012 in Switzerland (CH), traditionally PRRSV-free. It was detected after a German boar stud informed a semen importer about the detection of PRRSV during routine monitoring. Tracing of semen deliveries revealed 26 Swiss sow... | 25,209,832 | [
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Relationship and factor structure in multisystem neurodegeneration in Parkinson's disease. | Parkinson's disease (PD) is a multisystem neurodegenerative disease. We aimed to identify the relationship and factor structure among its different features. Motor, olfactory and cognitive function, and cardiac sympathetic denervation were evaluated in 125 patients with PD using the Unified Parkinson's Disease Rating S... | 25,209,841 | [
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Phthalates, perfluoroalkyl acids, metals and organochlorines and reproductive function: a multipollutant assessment in Greenlandic, Polish and Ukrainian men. | Numerous environmental contaminants have been linked to adverse reproductive health outcomes. However, the complex correlation structure of exposures and multiple testing issues limit the interpretation of existing evidence. Our objective was to identify, from a large set of contaminant exposures, exposure profiles ass... | 25,209,848 | [
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Expression and localization of a UT-B urea transporter in the human bladder. | Facilitative UT-B urea transporters have been shown to play an important role in the urinary concentrating mechanism. Recent studies have now suggested a link between UT-B allelic variation and human bladder cancer risk. UT-B1 protein has been previously identified in the bladder of various mammalian species, but not y... | 25,209,859 | [
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Evaluation of bone repair of critical size defects treated with simvastatin-loaded poly(lactic-co-glycolic acid) microspheres in rat calvaria. | Statins are hypolipemiant drugs with osteoinductive effect. We evaluated the potential of simvastatin loaded into poly(lactic-co-glycolic acid) (PLGA) microspheres to heal critical size defects in rat calvaria. PLGA scaffolds (50:50 ratio) were synthesized as pure membranes or as microspheres loaded with 2.5% simvastat... | 25,209,881 | [
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Specific language impairment in language-minority children from low-income families. | Recent evidence suggests that specific language impairment (SLI) might be secondary to general cognitive processing limitations in the domain of executive functioning. Previous research has focused almost exclusively on monolingual children with SLI and offers little evidence-based guidance on executive functioning in ... | 25,209,889 | [
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Associations between thyroid autoantibody status and abnormal pregnancy outcomes in euthyroid women. | We investigated whether thyroid autoantibody status influences pregnancy outcomes in euthyroid women, by comparing abnormal pregnancy outcome rates between those who tested positive for thyroid autoantibodies (Ab+) and those who tested autoantibody-negative (Ab-). Euthyroid pregnant women (n=7,641) underwent tests for ... | 25,209,893 | [
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Conditional shared confidentiality in mental health care. | Because of the development towards community care, care providers not only exchange information in a team, but increasingly also in networks. This is a challenge to confidentiality. The ethical question is how care providers can keep information about the care receiver confidential, whilst at the same time exchanging i... | 25,209,901 | [
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Phylogenetic Analysis of Canine Parvovirus VP2 Gene in China. | In this study, a total of 37 samples (58.0%) were found through PCR assay to be positive for canine parvovirus (CPV) of 66 suspected faecal samples of dogs collected from various cities throughout China. Eight CPV isolates could be obtained in the CRFK cell line. The sequencing of the VP2 gene of CPV identified the pre... | 25,209,922 | [
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Early-life exposure to climate change impairs tropical shark survival. | Sharks are one of the most threatened groups of marine animals worldwide, mostly owing to overfishing and habitat degradation/loss. Although these cartilaginous fish have evolved to fill many ecological niches across a wide range of habitats, they have limited capability to rapidly adapt to human-induced changes in the... | 25,209,942 | [
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TOKYO criteria 2014 for transpapillary biliary stenting. | It is difficult to carry out meta-analyses or to compare the results of different studies of biliary stents because there is no uniform evaluation method. Therefore, a standardized reporting system is required. We propose a new standardized system for reporting on biliary stents, the 'TOKYO criteria 2014', based on a c... | 25,209,944 | [
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Effects of loratadine and cetirizine on serum levels of neuropeptides in patients with chronic urticaria. | H1-receptor inhibiting drugs, namely loratadine and cetirizine, were frequently used in treatment of chronic urticaria. Urticarial weal and flare reactions, a neurogenic reflex due to neuropeptides, were reported to be more effectively inhibited by cetirizine than loratadine. The aim of this study was to determine and ... | 25,209,952 | [
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0.08... |
Revisiting yeast trehalose metabolism. | Establishing the function of trehalose in yeast cells has led us, over the years, through a long path-from simple energy storage carbohydrate, then a stabilizer and protector of membranes and proteins, through a safety valve against damage caused by oxygen radicals, up to regulator of the glycolytic path. In addition, ... | 25,209,979 | [
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Fetal inhibition of inflammation improves disease phenotypes in harlequin ichthyosis. | Harlequin ichthyosis (HI) is a severe skin disease which leads to neonatal death in ∼50% of cases. It is the result of mutations in ABCA12, a protein that transports lipids required to establish the protective skin barrier needed after birth. To better understand the life-threatening newborn HI phenotype, we analysed t... | 25,209,981 | [
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Factors associated with a delay in seeking HIV/AIDS treatment in São Paulo, Brazil. | This quantitative cross-sectional study of HIV/AIDS patients (N = 1,520) in São Paulo evaluated factors associated with a delay in seeking care. Analysis included Chi square tests and multiple logistic regression. Care was sought at the AIDS stage in 56.7 % (861) of patients, and 48.2 % (732) had a CD4 count ≤350 cells... | 25,210,003 | [
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Discovery of a highly selective PLD2 inhibitor (ML395): a new probe with improved physiochemical properties and broad-spectrum antiviral activity against influenza strains. | Further chemical optimization of the halopemide-derived family of dual phospholipase D1/2 (PLD1/2) inhibitors afforded ML395 (VU0468809), a potent, >80-fold PLD2 selective allosteric inhibitor (cellular PLD1, IC50 >30,000 nM; cellular PLD2, IC50 =360 nM). Moreover, ML395 possesses an attractive in vitro DMPK prof... | 25,210,004 | [
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Survival follow-up and ipilimumab retreatment of patients with advanced melanoma who received ipilimumab in prior phase II studies. | This report provides a survival update at a follow-up of >5 years (5.5-6 years) for patients with advanced melanoma who previously received ipilimumab in phase II clinical trials. Safety and efficacy data following ipilimumab retreatment are also reported. Patients who previously received ipilimumab 0.3, 3, or 10 mg... | 25,210,016 | [
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Unannounced in situ simulation of obstetric emergencies: staff perceptions and organisational impact. | To describe how unannounced in situ simulation (ISS) was perceived by healthcare professionals before and after its implementation, and to describe the organisational impact of ISS. Ten unannounced ISS involving all staff were scheduled March-August 2007. Questionnaire surveys on staff perceptions were conducted before... | 25,210,023 | [
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Massive thermal acceleration of the emergence of primordial chemistry, the incidence of spontaneous mutation, and the evolution of enzymes. | Kelvin considered it unlikely that sufficient time had elapsed on the earth for life to have reached its present level of complexity. In the warm surroundings in which life first appeared, however, elevated temperatures would have reduced the kinetic barriers to reaction. Recent experiments disclose the profound extent... | 25,210,030 | [
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Introduction to the thematic minireview series on enzyme evolution. | In this thematic minireview series, the JBC presents five provocative articles on Enzyme Evolution. The reviews discuss stimulating concepts that include the emergence of primordial catalysts at temperatures that were considerably warmer than present day ones and the impact of the cooling environment on the evolution o... | 25,210,045 | [
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Extracellular matrix modulates the biological effects of melatonin in mesenchymal stem cells. | Both self-renewal and lineage-specific differentiation of mesenchymal stem cells (MSCs) are triggered by their in vivo microenvironment including the extracellular matrix (ECM) and secreted hormones. The ECM may modulate the physiological functions of hormones by providing binding sites and by regulating downstream sig... | 25,210,047 | [
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Thiazolidinedione-induced lipid droplet formation during osteogenic differentiation. | Chronic administration of the insulin-sensitising drugs, thiazolidinediones (TZDs), results in low bone mineral density and 'fatty bones'. This is thought to be due, at least in part, to aberrant differentiation of progenitor mesenchymal stem cells (MSCs) away from osteogenesis towards adipogenesis. This study directly... | 25,210,048 | [
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Multilocus sequence typing of Mycobacterium xenopi. | Mycobacterium xenopi is an opportunistic mycobacterial pathogen of increasing clinical importance. Surveillance of M. xenopi is hampered by the absence of tools for genotyping and molecular epidemiology. In this study, we describe the development and evaluation of an effective multilocus sequence typing strategy for M.... | 25,210,065 | [
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Contemporary inter-hospital transfer patterns for the management of acute coronary syndrome patients: findings from the EPICOR study. | The EPICOR observational study was designed to describe antithrombotic strategies in a broad acute coronary syndrome (ACS) population; it also included information on inter-hospital transfers and institutional resources. EPICOR enrolled 10,568 consecutively discharged patients with ST-elevation (STE) or non-STE (NSTE) ... | 25,210,075 | [
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Preterm delivery among first-time Mexico-born mothers: a binational population-based comparison of deliveries in California and Mexico. | While studies have attributed the favourable birth outcomes of Mexico-born mothers in the USA to a 'healthy immigrant effect' that confers protection to immigrants, a comparison of immigrants with the source population in Mexico has been lacking. We compared preterm delivery (PTD) rates of Mexico-born immigrants who de... | 25,210,076 | [
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Assessing protective factors for sexually violent offending with the SAPROF. | The Structured Assessment of Protective Factors for violence risk (SAPROF) has recently been developed as a risk assessment tool to focus solely on protective factors for (sexual) violence risk. Research on protective factors for sexual offending is very limited and most risk assessment tools for adult sexual offenders... | 25,210,106 | [
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Heterologous immunological effects of early BCG vaccination in low-birth-weight infants in Guinea-Bissau: a randomized-controlled trial. | Bacillus Calmette-Guérin (BCG) seems to have beneficial nonspecific effects; early BCG vaccination of low-birth-weight (LBW) newborns reduces neonatal mortality by >40% due to prevention of primarily septicemia and pneumonia. Within a randomized trial in LBW infants in Guinea-Bissau of early BCG vs the usual postpon... | 25,210,141 | [
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Unraveling the complexity of lipid body organelles in human eosinophils. | Lipid-rich organelles are common in many cell types. In cells, such as adipocytes, these organelles are termed LDs, whereas in other cells, such as leukocytes, they are called LBs. The study of leukocyte LBs has attracted attention as a result of their association with human diseases. In leukocytes, such as eosinophils... | 25,210,147 | [
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Modulation of alpha power at encoding and retrieval tracks the precision of visual short-term memory. | Our ability to hold information in mind is strictly limited. We sought to understand the relationship between oscillatory brain activity and the allocation of resources within visual short-term memory (VSTM). Participants attempted to remember target arrows embedded among distracters and used a continuous method of res... | 25,210,151 | [
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Population interactions between parietal and primary motor cortices during reach. | Neural interactions between parietal area 2/5 and primary motor cortex (M1) were examined to determine the timing and behavioral correlates of cortico-cortical interactions. Neural activity in areas 2/5 and M1 was simultaneously recorded with 96-channel microelectrode arrays in three rhesus monkeys performing a center-... | 25,210,154 | [
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Regular-spiking cells in the presubiculum are hyperexcitable in a rat model of temporal lobe epilepsy. | Temporal lobe epilepsy (TLE) is the most common form of adult epilepsy, characterized by recurrent seizures originating in the temporal lobes. Here, we examine TLE-related changes in the presubiculum (PrS), a less-studied parahippocampal structure that both receives inputs from and projects to regions affected by TLE. ... | 25,210,155 | [
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Common features of mucosal and peripheral antibody responses elicited by candidate HIV-1 vaccines in rhesus monkeys. | Human immunodeficiency virus type 1 (HIV-1) vaccines that elicit protective antibody responses at mucosal sites would be highly desirable. Here, we report that intramuscular immunization of candidate HIV-1 vaccine vectors and purified Env proteins elicited potent and durable humoral immune responses in colorectal mucos... | 25,210,178 | [
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HBZ stimulates brain-derived neurotrophic factor/TrkB autocrine/paracrine signaling to promote survival of human T-cell leukemia virus type 1-Infected T cells. | Brain-derived neurotrophic factor (BDNF) is a neurotrophin that promotes neuronal proliferation, survival, and plasticity. These effects occur through autocrine and paracrine signaling events initiated by interactions between secreted BDNF and its high-affinity receptor, TrkB. A BDNF/TrkB autocrine/paracrine signaling ... | 25,210,182 | [
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Characterization of a broadly neutralizing monoclonal antibody that targets the fusion domain of group 2 influenza A virus hemagglutinin. | Due to continuous changes to its antigenic regions, influenza viruses can evade immune detection and cause a significant amount of morbidity and mortality around the world. Influenza vaccinations can protect against disease but must be annually reformulated to match the current circulating strains. In the development o... | 25,210,195 | [
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Trailing or paradoxical growth of Aspergillus flavus exposed to caspofungin is independent of genotype. | There are limited data on in vitro susceptibility testing of echinocandins against Aspergillus species. The objective of this study was to describe the phenotypes of Aspergillus flavus observed on exposure to caspofungin in vitro and to test whether these phenotypes were associated with A. flavus genotypes. The caspofu... | 25,210,202 | [
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In vitro activities of amphotericin B deoxycholate and liposomal amphotericin B against 604 clinical yeast isolates. | We determined the in vitro antifungal activity of liposomal amphotericin B (L-AmB) against 604 clinical yeast isolates. Amphotericin B deoxycholate (D-AmB) was tested in parallel against all the isolates. Susceptibility testing was performed according to the Clinical and Laboratory Standards Institute (CLSI) M27-A3 met... | 25,210,203 | [
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Video endoscopic oro-nasal visualisation of the anterior wall of maxillary sinus: a new technique. | The anterior wall of the maxillary sinus represents a blind spot in maxillary sinus endoscopic surgery because of the absence of proper visualisation and instrumentation to reach it. The aim of this study was to validate a new approach through the oral cavity into the nose with a flexible video endoscope (oro-nasal end... | 25,210,220 | [
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Repositioning template for mandibular reconstruction with fibular free flaps: an alternative technique to pre-plating and virtual surgical planning. | Oral malignancies involving the mandibular bone require a complex reconstructive plan. Mandibular reconstruction with a fibular free flap is currently considered the best choice for functional and aesthetic rehabilitation after oncological surgery. This flap can be modelled with multiple osteotomies and can provide bon... | 25,210,223 | [
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Cerebellar haemorrhage mimicking acute peripheral vestibulopathy: the role of the video head impulse test in differential diagnosis. | Dizziness and vertigo without neurological signs are typically due to a peripheral vestibular disease. Although the most common causes are benign, differential diagnosis must include potentially life-threatening central diseases such as cerebrovascular pathologies. A systemic clinical approach needs a careful work-up, ... | 25,210,225 | [
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0.1219017,... |
Diagnostic efficacy and importance of fine-needle aspiration cytology of thyroid nodules. | Fine-needle aspiration cytology (FNAC) in the diagnosis of thyroid nodules is an easy and cost-effective method. The increase in malignancy rates of the excised nodules due to the high sensitivity and specificity rates of the FNAC is remarkable. The aim of this study was to assess the effectiveness of FNAC in the evalu... | 25,210,233 | [
0.2081015,
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Anaplastic myeloma presenting as mandibular swelling: Diagnosis by cytology. | Multiple myeloma is a disease resulting from clonal proliferation of plasma cells. A disease of the elderly, jaw lesions are seen in 14% of patients affected with myeloma. Rarely the oral and maxillofacial lesions can be the first manifestation of the disease. We report the case of a 75-year-old man who presented with ... | 25,210,245 | [
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0.3472179,
0.1369958,
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A rare case of temporal arteritis with rheumatoid arthritis and interstitial lung disease mimicking pulpo-periodontal pathology. | A 75-year-old male patient was planned for dental treatment due to pain of suspected pulpo-periodontal origin in relation to right maxillary first molar. Careful evaluation revealed the pain to be non-odontogenic in nature and led to the diagnosis of temporal arteritis with rheumatoid arthritis along with interstitial ... | 25,210,275 | [
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0.1568955,
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Communication of radiation risk in nuclear medicine: Are we saying the right thing? | The radiation risk arising from nuclear medicine investigations represents a small but manageable risk to patients and it needs to be effectively communicated to them. Frequently in the culture of "doctor knows best," patients trust their doctors to do whatever is right and appropriate and leave it to them to worry abo... | 25,210,276 | [
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Exploring the role of technitium-99m dimercaptosuccinyl acid (V) scan in medullary carcinoma thyroid patients with postoperative persistent hypercalcitoninemia in the era of positron emission tomography-computerized tomography. | Many radio-pharmaceuticals have been used over the years to localize the recurrences in patients with medullary carcinoma thyroid (MCT), including iodine-131-metaiodobenzylguanidine, thallium-201, technitium-99m dimercaptosuccinyl acid [Tc-99m DMSA (V)], Tc-99m methoxyisobutylisonitril, Tc-99 ethylenediamine diacetic a... | 25,210,279 | [
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0.03073575,
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Post-treatment appearances, pitfalls, and patterns of failure in head and neck cancer on FDG PET/CT imaging. | Majority of patients with head and neck cancer are treated with combined treatment regimes such as surgery, radiation therapy, and chemotherapy. The loss of structural symmetry and imaging landmarks as a result of therapy makes post-treatment imaging a daunting task on conventional modalities like computed tomography (... | 25,210,280 | [
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0.2286686,
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Granulosa cell tumor induced massive recurrence of post hysterectomy leiomyoma. | The authors report a very unusual occurrence of a massive recurrence of leiomyoma from post hysterectomy stump diagnosed on fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-18-FDG PET/CT). The case also has an additional complexity of granulosa cell tumor (GCT) of ovary probably contri... | 25,210,289 | [
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... |
Simultaneous determination of four neuroprotective compounds of Tilia amurensis by high performance liquid chromatography coupled with diode array detector. | Tilia amurensis consists of various compounds, such as flavonoids and terpenoids. A simple and reliable high performance liquid chromatography (HPLC) coupled with the diode array detector (DAD) method has been established for simultaneous determination of epicatechin, nudiposide, lyoniside, and scopoletin isolated from... | 25,210,303 | [
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0.4339645,
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Qualitative and quantitative analysis of the major constituents in traditional Chinese medicine Danmu injection using LC-ESI-MS(n) and LC-DAD. | Danmu injection, a traditional Chinese medicine (TCM) preparation made from Nauclea officinalis, has been commonly used for the treatment of cold, fever, swelling of throat in China. However, the chemical constituents in Danmu injection have not been clarified yet. a HPLC/DAD/ESI-MS(n) method was developed for qualitat... | 25,210,312 | [
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0.432659,
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Antidepressant-like effects of Chaihu-Shugan-San via SAPK/JNK signal transduction in rat models of depression. | Chaihu-Shugan-San (CHSGS), a traditional Chinese medicinal herbal formula, registered in Jingyue Quanshu, has been indicated that oral administration of the extract from it can remit depressive disorder. C-Jun amino-terminal kinase (JNK/SAPK) signal transduction plays a key role in the apoptosis of nerve cells, be repo... | 25,210,314 | [
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0.159192... |
Content determination of the flavonoids in the different parts and different species of Abelmoschus esculentus L. by reversed phase-high performance liquid chromatograph and colorimetric method. | This research will establish the ultraviolet colorimetric method to determine the total flavonoid content in different species and different parts of Abelmoschus esculentus L. We establish the reversed-phase high-performance liquid chromatograph (RP-HPLC) method to determine the content of the three flavonoid glycoside... | 25,210,315 | [
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0.09779014,
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-0.16... |
Optimization of simultaneous ultrasonic-assisted extraction of water-soluble and fat-soluble characteristic constituents from Forsythiae Fructus Using response surface methodology and high-performance liquid chromatography. | The compounds (+)-pinoresinol-β-glucoside (1) forsythiaside, (2) phillyrin (3) and phillygenin (4) were elucidated to be the characteristic constituents for quality control of Forsythiae Fructus extract by chromatographic fingerprint in 2010 edition of Chinese Pharmacopoeia due to their numerous important pharmacologic... | 25,210,317 | [
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0.340676,
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-0.521... |
Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in A549 human lung cancer cells. | Methyl protodioscin (MPD) is a furostanol bisglycoside with antitumor properties. It has been shown to reduce proliferation, cause cell cycle arrest. The present study elucidates the mechanism underlying MPD's apoptotic effects, using the A549 human lung cancer cell line. The human pulmonary adenocarcinoma cell line A5... | 25,210,320 | [
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0.2506054,
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0.5469019,
0.7606264,
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-0.06104042,... |
A rapid identification of four medicinal chrysanthemum varieties with near infrared spectroscopy. | For genuine medicinal material in Chinese herbs; the efficient, rapid, and precise identification is the focus and difficulty in the filed studying Chinese herbal medicines. Chrysanthemum morifolium as herbs has a long planting history in China, culturing high quality ones and different varieties. Different chrysanthem... | 25,210,325 | [
0.1995092,
0.4170043,
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0.462162,
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0.148026,
0.4399965,
0.3213786,
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0.1047429... |
Beyond goosebumps: does the arrector pili muscle have a role in hair loss? | The arrector pili muscle (APM) consists of a small band of smooth muscle that connects the hair follicle to the connective tissue of the basement membrane. The APM mediates thermoregulation by contracting to increase air-trapping, but was thought to be vestigial in humans. The APM attaches proximally to the hair follic... | 25,210,331 | [
-0.1497178,
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0.1164673,
-0.322... |
Comparative clinical evaluation of transcutaneous electrical nerve stimulator over conventional local anesthesia in children seeking dental procedures: A clinical study. | The aim of this study to evaluate the effectiveness of pain control by employing transcutaneous electrical nerve stimulator (TENS) over conventional injectable local anesthesia for children requiring restorative procedures under rubber dam. The study design considered was the split mouth design, in experiment (right) s... | 25,210,350 | [
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0.2075189,
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Comparison of the frictional resistance between archwire and different bracket system: An in vitro study. | The purpose of this study is to evaluate the frictional resistance generated by conventional stainless steel, radiance ceramic bracket, self-ligating and composite brackets using a 0.019 × 0.025 stainless steel straight length wires in a 022 slot and to select brackets based on their frictional characteristic. In order... | 25,210,359 | [
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0.3512791,
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0.1561192,
... |
Prevalence of dental caries among school-going children in Namakkal district: A cross-sectional study. | The aim of this study is to determine the prevalence of dental caries in primary teeth among 4-6 years old school going children in the Namakkal District. The study covered a total of 850 school going children in a total of 26 schools in the Namakkal district of Tamil Nadu. The age group selected for this study ranged ... | 25,210,362 | [
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0.2841628,
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0.3... |
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