title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Estimation of soft- and hard-tissue thickness at implant sites. | Anchorage control is a critical consideration when planning treatment for patients with dental and skeletal malocclusions. To obtain sufficient stability of implants, the thickness of the soft tissue and the cortical-bone in the placement site must be considered; so as to provide an anatomical map in order to assist th... | 25,210,381 | [
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A study on evaluation of center of resistance of maxillary four incisors during simultaneous intrusion and retraction: A finite element study. | The aim of this study is to evaluate the center of resistance of maxillary incisors during simultaneous intrusion and retraction. In this study, the following steps were employed namely, (1) Preprocessing - the creation of geometric model, mesh generation and boundary conditions. (2) Postprocessing - the tooth movement... | 25,210,384 | [
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Immunohistochemical study of p53 and proliferating cell nuclear antigen expression in odontogenic keratocyst and periapical cyst. | p53 protein is a product of p53 gene, which is now classified as a tumor suppressor gene. The gene is a frequent target for mutation, being seen as a common step in the pathogenesis of many human cancers. Proliferating cell nuclear antigen (PCNA) is an auxiliary protein of DNA polymerase delta and plays a critical role... | 25,210,385 | [
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How and why of orthodontic bond failures: An in vivo study. | The bonding of orthodontic brackets and their failure rates by both direct and in-direct procedures are well-documented in orthodontic literature. Over the years different adhesive materials and various indirect bonding transfer procedures have been compared and evaluated for bond failure rates. The aim of our study is... | 25,210,392 | [
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Becoming a Coach in Developmental Adaptive Sailing: A Lifelong Learning Perspective. | Life-story methodology and innovative methods were used to explore the process of becoming a developmental adaptive sailing coach. Jarvis's (2009) lifelong learning theory framed the thematic analysis. The findings revealed that the coach, Jenny, was exposed from a young age to collaborative environments. Social intera... | 25,210,408 | [
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Patients' and Parents' Perceptions of Appearance in Scoliosis Treated with a Brace: A Cross-Sectional Analysis. | The perspective of trunk deformity is a matter of special concern for adolescent idiopathic scoliosis (AIS) patients. No research group has ever reported interviewing patients and their parents regarding differences in perception of body appearance in the course of Cheneau brace treatment. We aimed to investigate the l... | 25,210,419 | [
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Identification of gene signatures used to recognize biological characteristics of gastric cancer upon gene expression data. | High-throughput gene expression microarrays can be examined by machine-learning algorithms to identify gene signatures that recognize the biological characteristics of specific human diseases, including cancer, with high sensitivity and specificity. A previous study compared 20 gastric cancer (GC) samples against 20 no... | 25,210,421 | [
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A Continuous Flow System for the Measurement of Ambient Nitrogen Oxides [NO + NO2] Using Rhodamine B Hydrazide as a Chemosensor. | A new chemosensor has been used to monitor atmospheric nitrogen oxides [NO + NO2] at parts per billion (ppb) level. It is based on the catalytic reaction of nitrogen oxides with rhodamine B hydrazide (RBH) to produce a colored compound through the hydrolysis of the amide bond of the molecule. A simple colorimeter has b... | 25,210,422 | [
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Retinal breaks due to intravitreal ocriplasmin. | Ocriplasmin represents a new treatment option for numerous vitreoretinopathies involving an abnormal vitreomacular interface. While the drug may circumvent the traditional risks of surgical treatment, pharmacologic vitreolysis is not devoid of risk itself. This report presents two cases, one of vitreomacular traction s... | 25,210,426 | [
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Perioperative and postoperative risk factors for corneal graft failure. | In this study, we assessed the outcome of penetrating keratoplasties using organ-cultured corneal tissues at the University Eye Hospital, Ludwig-Maximilians-University, Munich, Germany. The goal was to identify perioperative and postoperative risk factors that may affect graft survival. The medical records of 377 patie... | 25,210,433 | [
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Hepatotoxicity induced by clozapine: a case report and review of literature. | Clozapine is an effective antipsychotic drug but is associated with serious side effects. Most treatment guidelines give no clear recommendations on regular monitoring of liver function tests, even though up to 60% of patients experience elevations in hepatic transaminases, with 15% to 30% experiencing an elevation two... | 25,210,451 | [
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The safety and effectiveness of open-label extended-release carbamazepine in the treatment of children and adolescents with bipolar I disorder suffering from a manic or mixed episode. | To assess the safety and effectiveness of open-label treatment with extended-release carbamazepine (ERC) in pediatric subjects suffering from bipolar I disorder. Medically healthy youths aged 10-17 years suffering from an acute manic or mixed episode were eligible. After screening for study eligibility, the youths bega... | 25,210,452 | [
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Extraintestinal helminth infection reduces the development of colitis-associated tumorigenesis. | Colitis-associated colorectal cancer (CAC) is one of the most common cancers and is closely related to chronic or deregulated inflammation. Helminthic infections can modulate inflammatory responses in some diseases, but their immunomodulatory role during cancer development remains completely unknown. We have analyzed t... | 25,210,492 | [
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microRNAs in spinal cord injury: potential roles and therapeutic implications. | microRNAs (miRNAs) are a novel class of small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. miRNAs can modulate gene expression and thus play important roles in diverse neurobiological processes, such as cell differentiation, growth, proliferation and neural activity, as we... | 25,210,498 | [
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Changes in endotracheal tube cuff pressure during laparoscopic surgery in head-up or head-down position. | The abdominal insufflation and surgical positioning in the laparoscopic surgery have been reported to result in an increase of airway pressure. However, associated effects on changes of endotracheal tube cuff pressure are not well established. 70 patients undergoing elective laparoscopic colorectal tumor resection (hea... | 25,210,501 | [
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Laparoscopic Reversal of Hartmann's Procedure: State of the Art 20 Years after the First Reported Case. | Introduction. Aim of the present work is to review the literature to point out the role of laparoscopic reversal of Hartmann procedure. Material and Methods. Number of patients, age, sex, etiology, Hinchey classification, interval between procedure and reversal, position of the first trocars, mean operative time (min),... | 25,210,510 | [
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Urinary Trypsin Inhibitor Ameliorates Seawater Immersion-Induced Intestinal Mucosa Injury via Antioxidation, Modulation of NF-κB Activity, and Its Related Cytokines in Rats with Open Abdominal Injury. | Objective. To investigate the role of oxidative stress, NF-κB activity, and its related cytokines in the pathogenesis of seawater immersion after open abdominal injury (SI-OAI) and whether UTI treatment can attenuate SI-OAI induced IMI. Methods. Wistar rats were randomly divided into three groups: C group, S group, and... | 25,210,512 | [
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Primary circulating prostate cells are not detected in men with low grade small volume prostate cancer. | Objective. To determine if primary circulating prostate cells (CPCs) are found in all men with prostate cancer. Methods and Patients. A prospective study, to analyze all men with an elevated PSA between 4.0 and 10.0 ng/mL undergoing initial biopsy. Primary CPCs were obtained by differential gel centrifugation and detec... | 25,210,517 | [
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Developmental profiles of preschool children with delayed language development. | This study examines changes in developmental profiles of children with language delay over time and the clinical significance of assessment conducted at age 2-3 years. We retrospectively reviewed the medical records of 70 children (62 male, 8 female), who had visited the hospital because of delayed language development... | 25,210,524 | [
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Current epidemiology and clinical practice in arboviral infections - implications on blood supply in South-East Asia. | Arthropod-borne viruses (arboviruses) are a growing threat to global health. Complex vector-virus-host interactions lead to unpredictable epidemiological patterns. Difficulties in accurate surveillance including imperfect diagnostic tools impair effective response to outbreaks. With arboviral infections causing a wide ... | 25,210,534 | [
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Benign phyllodes tumour of the prostate: An extremely rare entity. | Benign phyllodes tumour (BPT) of the prostate is a very rare neoplasm. It is composed of hyperplastic and neoplastic glandular stromal proliferation. Patients with BPT of the prostate generally present with lower urinary tract symptoms and hematuria. BPT of the prostate can potentially cause recurrent obstructive sympt... | 25,210,561 | [
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A baseline measure of tree and gastropod biodiversity in replanted and natural mangrove stands in malaysia: langkawi island and sungai merbok. | THE DIVERSITIES OF MANGROVE TREES AND OF THEIR ASSOCIATED GASTROPODS WERE ASSESSED FOR TWO MANGROVE REGIONS ON THE WEST COAST OF PENINSULAR MALAYSIA: Langkawi Island and Sungai Merbok. The mangrove area sampled on Langkawi Island was recently logged and replanted, whereas the area sampled in Sungai Merbok was part of a... | 25,210,584 | [
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Structure and function of nucleotide sugar transporters: Current progress. | The proteomes of eukaryotes, bacteria and archaea are highly diverse due, in part, to the complex post-translational modification of protein glycosylation. The diversity of glycosylation in eukaryotes is reliant on nucleotide sugar transporters to translocate specific nucleotide sugars that are synthesised in the cytos... | 25,210,595 | [
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Nigrostriatal dynein changes in A53T alpha-synuclein transgenic mice. | The accumulation of misfolded a-synuclein is mechanistically linked to neurodegeneration in Parkinson's disease (PD) and other alpha-synucleinopathies. However, how alpha-synuclein causes neurodegeneration is unresolved. Several studies have supported the involvement of dynein, the major motor for retrograde axonal tra... | 25,210,616 | [
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An explanatory evo-devo model for the developmental hourglass. | The "developmental hourglass'' describes a pattern of increasing morphological divergence towards earlier and later embryonic development, separated by a period of significant conservation across distant species (the "phylotypic stage''). Recent studies have found evidence in support of the hourglass effect at the geno... | 25,210,617 | [
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Case Report: Solitary mastocytoma treated successfully with topical tacrolimus. | Solitary mastocytoma, a rare dermatological entity accounts for 10-15% of cutaneous mastocytosis. We report a rare case of solitary mastocytoma presenting at birth, treated successfully with topical tacrolimus. Along with reassurance and strict avoidance of triggering factors, no recurrence was reported within the one ... | 25,210,620 | [
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Anterior spinal artery syndrome: reversible paraplegia after minimally invasive spine surgery. | Background Context. Percutaneous balloon kyphoplasty is an established minimally invasive technique to treat painful vertebral compression fractures, especially in the context of osteoporosis with a minor complication rate. Purpose. To describe the heparin anticoagulation treatment of paraplegia following balloon kypho... | 25,210,639 | [
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Global Clustering Quality Coefficient Assessing the Efficiency of PCA Class Assignment. | An essential factor influencing the efficiency of the predictive models built with principal component analysis (PCA) is the quality of the data clustering revealed by the score plots. The sensitivity and selectivity of the class assignment are strongly influenced by the relative position of the clusters and by their d... | 25,210,644 | [
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0.0707674,
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0.0312685... |
Anesthetic challenges for deep brain stimulation: a systematic approach. | Ablative intracranial surgery for Parkinson's disease has advanced to embedding electrodes into precise areas of the basal ganglia. Electrode implantation surgery, referred to as deep brain stimulation (DBS), is preferred in view of its reversibility, adjustability, and capability to be safely performed bilaterally. DB... | 25,210,668 | [
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A novel method of brainstem auditory evoked potentials using complex verbal stimuli. | The click and tone-evoked auditory brainstem responses are widely used in clinical practice due to their consistency and predictability. More recently, the speech-evoked responses have been used to evaluate subcortical processing of complex signals, not revealed by responses to clicks and tones. Disyllable stimuli corr... | 25,210,677 | [
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Regression of Colonic Adenomas After Treatment With Sulindac in Familial Adenomatous Polyposis: A Case With a 2-Year Follow-up Without a Prophylactic Colectomy. | Familial adenomatous polyposis (FAP) is an autosomal dominant disorder characterized by hundreds of colorectal adenomatous polyps that progress to colorectal cancer. Management of patients with FAP is with a total colectomy. Chemopreventive strategies have been studied in FAP patients in an effort to delay the developm... | 25,210,691 | [
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Influence of aging on visual perception and visual motor integration in Korean adults. | This study investigated age-related changes of cognitive function in Korean adults using the Korean-Developmental Test of Visual Perception-2 (K-DTVP-2) and the Visual Motor Integration-3rd Revision (VMI-3R) test, and determined the main factors influencing VP and VMI in older adults. For this research, 139 adults for ... | 25,210,701 | [
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Negative regulation of GADD34 on myofibroblasts during cutaneous wound healing. | The growth arrest and DNA damage-inducible protein, GADD34, has been proved to be involved in TGF-β signaling pathway and correlates with cell death, which are two important mechanisms in regulating myofibroblast differentiation and apoptosis during tissue repair. But roles of GADD34 in myofibroblasts differentiation a... | 25,210,702 | [
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Conditioned media from microvascular endothelial cells cultured in simulated microgravity inhibit osteoblast activity. | Gravity contributes to the maintenance of bone integrity. Accordingly, weightlessness conditions during space flight accelerate bone loss and experimental models in real and simulated microgravity show decreased osteoblastic and increased osteoclastic activities. It is well known that the endothelium and bone cells cro... | 25,210,716 | [
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Influenza prevention and treatment by passive immunization. | Passive immunity is defined as a particular antigen resistance provided by external antibodies. It can be either naturally or artificially acquired. Natural passive immunization occurs during pregnancy and breast-feeding in mammals and during hatching in birds. Maternal antibodies are passed through the placenta and mi... | 25,210,721 | [
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Salusin-β, but not salusin-α, promotes human umbilical vein endothelial cell inflammation via the p38 MAPK/JNK-NF-κB pathway. | Recently, salusin-β has been reported to have pro-atherosclerotic effects, but salusin-α has anti-atherosclerotic effects. Our previous study has shown that salusin-β but not salusin-α promotes vascular inflammation in apoE-deficient mice. However, the underlying mechanism remains unknown. In this study, we observed th... | 25,210,730 | [
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Mapping seabird sensitivity to offshore wind farms. | We present a Geographic Information System (GIS) tool, SeaMaST (Seabird Mapping and Sensitivity Tool), to provide evidence on the use of sea areas by seabirds and inshore waterbirds in English territorial waters, mapping their relative sensitivity to offshore wind farms. SeaMaST is a freely available evidence source fo... | 25,210,739 | [
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Prognostic factors in pediatric differentiated thyroid cancer patients with pulmonary metastases. | This study was aimed at identifying the prognostic factors predicting remission in pediatric differentiated thyroid cancer (DTC) patients presenting with pulmonary metastases. Little is known about the prognostic factors in reference to pediatric DTC patients presenting with pulmonary metastases. Fifty-three DTC patien... | 25,210,762 | [
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Molecular simulation-based structural prediction of protein complexes in mass spectrometry: the human insulin dimer. | Protein electrospray ionization (ESI) mass spectrometry (MS)-based techniques are widely used to provide insight into structural proteomics under the assumption that non-covalent protein complexes being transferred into the gas phase preserve basically the same intermolecular interactions as in solution. Here we invest... | 25,210,764 | [
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Hidden diversity in honey bee gut symbionts detected by single-cell genomics. | Microbial communities in animal guts are composed of diverse, specialized bacterial species, but little is known about how gut bacteria diversify to produce genetically and ecologically distinct entities. The gut microbiota of the honey bee, Apis mellifera, presents a useful model, because it consists of a small number... | 25,210,772 | [
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UDP glucuronosyltransferase 1A expression levels determine the response of colorectal cancer cells to the heat shock protein 90 inhibitor ganetespib. | HSP90 inhibition represents a promising route to cancer therapy, taking advantage of cancer cell-inherent proteotoxic stress. The HSP90-inhibitor ganetespib showed benefit in advanced clinical trials. This raises the need to identify the molecular determinants of treatment response. We tested the efficacy of ganetespib... | 25,210,794 | [
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A prospective randomized study of operative treatment for noncomminuted humeral shaft fractures: conventional open plating versus minimal invasive plate osteosynthesis. | To compare the clinical and radiologic results of conventional open plating (COP) and minimally invasive plate osteosynthesis (MIPO) in the treatment of noncomminuted humeral shaft fractures. Randomized prospective study. Five level 1 trauma centers. Sixty-eight consecutive patients were randomized into 2 study groups:... | 25,210,833 | [
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Two-dimensional layered semiconductor/graphene heterostructures for solar photovoltaic applications. | Schottky barriers formed by graphene (monolayer, bilayer, and multilayer) on 2D layered semiconductor tungsten disulfide (WS2) nanosheets are explored for solar energy harvesting. The characteristics of the graphene-WS2 Schottky junction vary significantly with the number of graphene layers on WS2, resulting in differe... | 25,210,837 | [
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Dual-phase CT collateral score: a predictor of clinical outcome in patients with acute ischemic stroke. | The presence of good collaterals on CT angiography (CTA) is a well-known predictor for favorable outcome in acute ischemic stroke. Recently, multiphase CT has been introduced as a more accurate method in assessing collaterals. The aim of this study was to assess the ability of dual-phase CT to evaluate collateral statu... | 25,210,853 | [
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Relationship between violent behavior and repeated weight-loss dieting among female adolescents in Japan. | To examine whether interpersonal violence perpetration and violence toward objects are associated with body mass index (BMI), body weight perception (BWP), and repeated weight-loss dieting in female adolescents. A cross-sectional survey using a self-report questionnaire was performed evaluating interpersonal violence p... | 25,210,854 | [
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Determinants of altered sleep-wake rhythmicity in patients treated for nonfunctioning pituitary macroadenomas. | In a cohort of 17 patients treated for nonfunctioning pituitary macroadenoma (NFMA), we observed alterations in polysomnographic sleep characteristics and actigraphic sleep-wake rhythmicity, and subjective fatigue, daytime somnolence, and low sleep quality. We aimed to confirm the actigraphic data in a larger scale coh... | 25,210,880 | [
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Evolution of the deaths registry system in Brazil: associations with changes in the mortality profile, under-registration of death counts, and ill-defined causes of death. | This paper examines the spatial pattern of ill-defined causes of death across Brazilian regions, and its relationship with the evolution of completeness of the deaths registry and changes in the mortality age profile. We make use of the Brazilian Health Informatics Department mortality database and population censuses ... | 25,210,911 | [
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The phenotypic and genotypic spectra of ichthyosis with confetti plus novel genetic variation in the 3' end of KRT10: from disease to a syndrome. | Ichthyosis with confetti (IWC) is a genodermatosis caused by dominant negative mutations in the gene encoding keratin 10 (KRT10). We investigated clinical and genetic details of a substantial number of patients with IWC in order to define major and minor criteria for diagnosis of this rare disorder. Parallel clinical i... | 25,210,931 | [
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Evaluating the risks of clinical research: direct comparative analysis. | Many guidelines and regulations allow children and adolescents to be enrolled in research without the prospect of clinical benefit when it poses minimal risk. However, few systematic methods exist to determine when research risks are minimal. This situation has led to significant variation in minimal risk judgments, ra... | 25,210,944 | [
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Default spacing is the optimal spacing for word reading. | Increased interletter spacing is thought to reduce crowding effects and to enhance fluent reading. Several studies have shown beneficial effects of increased interletter spacing on reading speed and accuracy, especially in poor readers. Therefore, increased interletter spacing appears to be a relatively easy way to enh... | 25,210,997 | [
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Differences in preeclampsia rates between African American and Caucasian women: trends from the National Hospital Discharge Survey. | African Americans are at higher risk for preeclampsia compared with Caucasians, but longitudinal changes are unknown. We hypothesized that preeclampsia rates among African Americans would be higher than that of Caucasians and over time would maintain a consistent divergence. We analyzed the annual prevalence rates and ... | 25,211,000 | [
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Determination of relative ion chamber calibration coefficients from depth-ionization measurements in clinical electron beams. | A method is presented to obtain ion chamber calibration coefficients relative to secondary standard reference chambers in electron beams using depth-ionization measurements. Results are obtained as a function of depth and average electron energy at depth in 4, 8, 12 and 18 MeV electron beams from the NRC Elekta Precise... | 25,211,012 | [
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The Development of the Sexual Assertiveness Questionnaire (SAQ): A Comprehensive Measure of Sexual Assertiveness for Women. | Sexual assertiveness has been defined in a number of ways by many researchers, with different aspects of sexual assertiveness emphasized in different measures. Most previous measures have included condom insistence as an important aspect of sexual assertiveness, but this may not translate well to women at all life stag... | 25,211,014 | [
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Human serotonin receptor 5-HT(1A) preferentially segregates to the liquid disordered phase in synthetic lipid bilayers. | We demonstrate successful incorporation of the G protein coupled receptor 5-HT1A into giant unilamellar vesicles using an agarose rehydration method. With direct observation using fluorescence techniques, we report preferential segregation of 5-HT1A into the cholesterol-poor liquid disordered phase of the membrane, con... | 25,211,019 | [
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Supranuclear eye movement disorders. | This work reviews supranuclear ocular motor disorders, highlighting new data published during the past year. Perceptional adaptative mechanisms may explain recent research concerning the discrepancy between objective measurement of saccade abnormalities and their putative functional visual impairment. Eye movement clas... | 25,211,041 | [
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Early myocardial deformation changes in hypercholesterolemic and obese children and adolescents: a 2D and 3D speckle tracking echocardiography study. | Dyslipidemia and obesity are considered strong risk factors for premature atherosclerotic cardiovascular disease and increased morbidity and mortality and may have a negative impact on myocardial function.Our purpose was to assess the presence of early myocardial deformation abnormalities in dyslipidemic children free ... | 25,211,047 | [
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Echocardiographic assessment of estimated right atrial pressure and size predicts mortality in pulmonary arterial hypertension. | Elevated mean right atrial pressure (RAP) measured by cardiac catheterization is an independent risk factor for mortality. Prior studies have demonstrated a modest correlation with invasive and noninvasive echocardiographic RAP, but the prognostic impact of estimated right atrial pressure (eRAP) has not been previously... | 25,211,049 | [
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One-step synthesis of dual clickable nanospheres via ultrasonic-assisted click polymerization for biological applications. | Dual clickable nanospheres (DCNSs) were synthesized in one step using an efficient approach of ultrasonic-assisted azide-alkyne click polymerization, avoiding the need of surfactants. This novel approach presents a direct clickable monomer-to-nanosphere synthesis. Field emission scanning electron microscopy (FESEM), Fo... | 25,211,060 | [
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NMD: nonsense-mediated defense. | Initially described as an RNA surveillance pathway, nonsense-mediated decay (NMD) is also recognized to function in the regulation of host gene expression. In this issue of Cell Host & Microbe, three studies describe NMD-mediated defense strategies of plants and mammalian cells in response to pathogen infection. | 25,211,070 | [
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The interferon signaling antagonist function of yellow fever virus NS5 protein is activated by type I interferon. | To successfully establish infection, flaviviruses have to overcome the antiviral state induced by type I interferon (IFN-I). The nonstructural NS5 proteins of several flaviviruses antagonize IFN-I signaling. Here we show that yellow fever virus (YFV) inhibits IFN-I signaling through a unique mechanism that involves bin... | 25,211,074 | [
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Benefits of caloric restriction in the myenteric neuronal plasticity in aging rats. | Aging is a biologic process characterized by progressive damage of structures and functions of organic systems. In gastrointestinal tract, it can involve enteric nervous system, which plays an important role in digestion and absorption of nutrients, causing hastening of intestinal transit thus reducing its absorptive f... | 25,211,115 | [
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Flexible transparent conducting hybrid film using a surface-embedded copper nanowire network: a highly oxidation-resistant copper nanowire electrode for flexible optoelectronics. | We report a flexible high-performance conducting film using an embedded copper nanowire transparent conducting electrode; this material can be used as a transparent electrode platform for typical flexible optoelectronic devices. The monolithic composite structure of our transparent conducting film enables simultaneousl... | 25,211,125 | [
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Predicting the mosquito species and vertebrate species involved in the theoretical transmission of Rift Valley fever virus in the United States. | Rift Valley fever virus (RVFV) is a mosquito-borne virus in the family Bunyaviridiae that has spread throughout continental Africa to Madagascar and the Arabian Peninsula. The establishment of RVFV in North America would have serious consequences for human and animal health in addition to a significant economic impact ... | 25,211,133 | [
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The natural history of spinal neurofibromatosis: a critical review of clinical and genetic features. | Spinal neurofibromatosis (SNF) is a related form of neurofibromatosis 1 (NF1), characterized by bilateral neurofibromas (histologically proven) of all spinal roots (and, eventually, of all the major peripheral nerve branches) with or without other manifestations of classical NF1. By rigorous application of these criter... | 25,211,147 | [
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Statistical detection of quantitative protein biomarkers provides insights into signaling networks deregulated in acute myeloid leukemia. | The increasing coverage and sensitivity of LC-MS/MS-based proteomics have expanded its applications in systems medicine. In particular, label-free quantitation approaches are enabling biomarker discovery in terms of statistical comparison of proteomic profiles across large numbers of clinical samples. However, it still... | 25,211,154 | [
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c-MET expression in primary and liver metastases in uveal melanoma. | There is a pressing need for effective therapies to treat uveal melanoma. Agents that inhibit the c-MET pathway have shown promise in multiple malignancies that overexpress c-MET. Herein, we assess c-MET expression in both primary uveal melanoma and liver metastases of uveal melanoma and evaluate the association of c-M... | 25,211,165 | [
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Butorphanol suppression of histamine itch is mediated by nucleus accumbens and septal nuclei: a pharmacological fMRI study. | Opioid receptors in the central nervous system are important modulators of itch transmission. In this study, we examined the effect of mixed-action opioid butorphanol on histamine itch, cowhage itch, and heat pain in healthy volunteers. Using functional MRI, we investigated significant changes in cerebral perfusion to ... | 25,211,175 | [
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Preclinical safety evaluation of a recombinant AAV8 vector for X-linked retinoschisis after intravitreal administration in rabbits. | X-linked retinoschisis (XLRS) is a retinal disease caused by mutations in the gene encoding the protein retinoschisin (RS1) and one of the most common causes of macular degeneration in young men. Currently, no FDA-approved treatments are available for XLRS and a replacement gene therapy could provide a promising strate... | 25,211,193 | [
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Doppler-based flow rate sensing in microfluidic channels. | We design, fabricate and experimentally demonstrate a novel generic method to detect flow rates and precise changes of flow velocity in microfluidic devices. Using our method we can measure flow rates of ~2 mm/s with a resolution of 0.08 mm/s. The operation principle is based on the Doppler shifting of light diffracted... | 25,211,195 | [
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PTEN hopping on the cell membrane is regulated via a positively-charged C2 domain. | PTEN, a tumor suppressor that is frequently mutated in a wide spectrum of cancers, exerts PI(3,4,5)P3 phosphatase activities that are regulated by its dynamic shuttling between the membrane and cytoplasm. Direct observation of PTEN in the interfacial environment can offer quantitative information about the shuttling dy... | 25,211,206 | [
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The effect of peer influence and selection processes on adolescent alcohol use: a systematic review of longitudinal studies. | Adolescent alcohol use remains an important public health concern. One of the most salient and consistent predictors for drinking behaviour among young people is peer influence. A systematic review of longitudinal studies that examined the effect of peer influence on adolescent alcohol use between January 1997 and Febr... | 25,211,209 | [
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A remote monitoring system for artificial pancreas support is safe, reliable, and user friendly. | We developed a unique remote monitoring and control diabetes management system (MDRS) supporting the use of an artificial pancreas (AP) at home. In this study, we aimed at assessing the efficacy and safety of the MDRS and its ability to prevent or shorten nocturnal hypoglycemia episodes without the use of an AP, as wel... | 25,211,216 | [
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Mycobacterium tuberculosis DosR is required for activity of the PmbtB and PmbtI promoters under hypoxia. | Mycobacterium tuberculosis has the ability to survive for extended periods of time under conditions of low oxygen, low pH, low iron and low nutrients. The mycobactins (M. tuberculosis siderophores) play a key role in scavenging iron from the environment and are induced in response to low iron in an IdeR-regulated manne... | 25,211,224 | [
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Frequencies and geographic distributions of genetic mutations in transthyretin- and non-transthyretin-related familial amyloidosis. | Inherited forms of amyloidosis are rare; of these, transthyretin-related (ATTR) is the most common, but non-ATTR has been described as well. We studied a large case series of ATTR and a small series of non-ATTR to better determine the mutation frequencies and geographic distributions of these inherited forms of amyloid... | 25,211,232 | [
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Incomplete deletion of IL-4Rα by LysM(Cre) reveals distinct subsets of M2 macrophages controlling inflammation and fibrosis in chronic schistosomiasis. | Mice expressing a Cre recombinase from the lysozyme M-encoding locus (Lyz2) have been widely used to dissect gene function in macrophages and neutrophils. Here, we show that while naïve resident tissue macrophages from IL-4Rαf(lox/delta)LysM(Cre) mice almost completely lose IL-4Rα function, a large fraction of macropha... | 25,211,233 | [
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Genome information of Methylobacterium oryzae, a plant-probiotic methylotroph in the phyllosphere. | Pink-pigmented facultative methylotrophs in the Rhizobiales are widespread in the environment, and many Methylobacterium species associated with plants produce plant growth-promoting substances. To gain insights into the life style at the phyllosphere and the genetic bases of plant growth promotion, we determined and a... | 25,211,235 | [
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Time-to-readmission and Mortality After High-risk Surgery. | To determine if mortality varies by time-to-readmission (TTR). Although readmissions reduction is a national health care priority, little progress has been made toward understanding why only some readmissions lead to adverse outcomes. In this retrospective cross-sectional cohort analysis, we used 2005-2009 Medicare dat... | 25,211,274 | [
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A tale of two morphs: modeling pollen transfer, magic traits, and reproductive isolation in parapatry. | The evolution of the flower is commonly thought to have spurred angiosperm diversification. Similarly, particular floral traits might have promoted diversification within specific angiosperm clades. We hypothesize that traits promoting the precise positional transfer of pollen between flowers might promote diversificat... | 25,211,280 | [
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Spiramycin/cotrimoxazole versus pyrimethamine/sulfonamide and spiramycin alone for the treatment of toxoplasmosis in pregnancy. | To compare the effectiviness of spiramycin/cotrimoxazole (Sp/C) versus pyrimethamine/sulfonamide (Pyr/Sul) and spiramycin alone (Spy) on mother-to-child transmission of toxoplasmosis infection in pregnancy. Retrospective study of pregnant women evaluated for suspected toxoplasmosis between 1992 and 2011. A total of 120... | 25,211,284 | [
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Is radiological appearance of lower respiratory tract infection due to respiratory syncytial virus a predictor of clinical outcome? | Respiratory syncytial virus (RSV) lower respiratory tract infection is the most common viral infection in childhood. RSV-infected infants demonstrate various radiographic findings. The aim of the study is to evaluate whether assessment of radiological characteristics of lower tract infection due to RSV may be a predict... | 25,211,292 | [
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Prevalence of rheumatic heart disease in a public school of Belo Horizonte. | Previous studies indicate that compared with physical examination, Doppler echocardiography identifies a larger number of cases of rheumatic heart disease in apparently healthy individuals. To determine the prevalence of rheumatic heart disease among students in a public school of Belo Horizonte by clinical evaluation ... | 25,211,312 | [
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Estrogen decreases anoikis of ovarian cancer cell line Caov-3 through reducing release of Bit1. | Few studies have referred to the implication of anoikis processes following hormonal treatment. No data are available on the influence of estrogen in ovarian cancer anoikis. To gain insights into the effects and mechanism of estrogen in ovarian cancer cells, we have carried out studies on the anoikis of ovarian cancer ... | 25,211,327 | [
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Serological diagnosis of paracoccidioidomycosis: high rate of inter-laboratorial variability among medical mycology reference centers. | Serological tests have long been established as rapid, simple and inexpensive tools for the diagnosis and follow-up of PCM. However, different protocols and antigen preparations are used and the few attempts to standardize the routine serological methods have not succeeded. We compared the performance of six Brazilian ... | 25,211,336 | [
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0.3989198,
0.1933639,
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0.087401,
0.03948874,
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-0.0833413,
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0.1521142,
0.1625808,
0.1839221,
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-... |
Mutation of a Salmonella serogroup-C1-specific gene abrogates O7-antigen biosynthesis and triggers NaCl-dependent motility deficiency. | Several molecular detection marker genes specific for a number of individual Salmonella serogroups have been recently identified in our lab by comparative genomics for the genotyping of diverse serogroups. To further understand the correlation between serotype and genotype, the function of a Salmonella serogroup-C1-spe... | 25,211,341 | [
0.1379637,
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Potentiometric, electronic, and transient absorptive spectroscopic properties of oxidized single-walled carbon nanotubes helically wrapped by ionic, semiconducting polymers in aqueous and organic media. | We report the first direct cyclic voltammetric determination of the valence and conduction band energy levels for noncovalently modified (6,5) chirality enriched SWNTs [(6,5) SWNTs] in which an aryleneethynylene polymer monolayer helically wraps the nanotube surface at periodic and constant morphology. Potentiometric p... | 25,211,354 | [
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0.03871796,
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Caffeine's Ergogenic Effects on Cycling: Neuromuscular and Perceptual Factors. | Caffeine improves endurance exercise performance, but its ergogenic mechanism(s) remain unclear. This investigation sought to examine the effects of caffeine on perceptual and physiological responses to endurance exercise. Two experiments were performed. In study A, 14 participants were tested. Maximal voluntary streng... | 25,211,364 | [
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Measured and estimated energy cost of constant and shuttle running in soccer players. | Players in team sports like soccer often make acceleration and deceleration movements, which are more energetically demanding than running at constant speed. The first aim of the present study was to estimate this difference in associated energy cost. To this end, we compared the actual energy cost of shuttle running t... | 25,211,365 | [
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Crystal structure and electronic structure of CePt2In7. | We report a corrected crystal structure for the CePt(2)In(7) superconductor, refined from single crystal x-ray diffraction data. The corrected crystal structure shows a different Pt-In stacking along the c-direction in this layered material than was previously reported. In addition, all of the atomic sites are fully oc... | 25,211,386 | [
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Purification and partial biochemical characterization of polyphenol oxidase from mango (Mangifera indica cv. Manila). | Polyphenol oxidase (PPO) is an enzyme widely distributed in the plant kingdom that has been detected in most fruits and vegetables. PPO was extracted and purified from Manila mango (Mangifera indica), and its biochemical properties were studied. PPO was purified 216-fold by hydrophobic interaction and ion exchange chro... | 25,211,397 | [
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History of syphilis in women living with AIDS and associated risk factors in São Paulo, Brazil. | to describe the epidemiological profile, risk behaviors, frequency of prior history of syphilis in women living with AIDS and to investigate associated factors. a cross-sectional study conducted with women living with HIV attending at Reference Center for AIDS in São Paulo. Demographic, behavioral, and clinical data we... | 25,211,418 | [
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[Insulin resistance and components of metabolic syndrome, analysis by gender and stage of adolescence]. | To analyze the influence of metabolic syndrome components in insulin resistance, by gender and adolescence phase. We evaluated biochemical, clinical, lifestyle and body composition data of 800 adolescents from 10 to 19 years old, from both genders, from Viçosa, MG/Brasil, and there was the division by stage: early (10 ... | 25,211,443 | [
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The efficacy of cognitive behavioural therapy and advocacy interventions for women who have experienced intimate partner violence: a systematic review and meta-analysis. | To determine the efficacy of Advocacy and Cognitive Behavioural Therapy interventions (CBT) in reducing physical, psychological, sexual, or any intimate partner violence (IPV). A systematic review and meta-analysis were conducted using randomized control trials (RCTs) published in MEDLINE, PsycINFO, Scopus, Cochrane, a... | 25,211,469 | [
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0.4377931,
0.01047458,
0.2105488,
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0.3823767,
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Stability of the wMel Wolbachia Infection following invasion into Aedes aegypti populations. | The wMel infection of Drosophila melanogaster was successfully transferred into Aedes aegypti mosquitoes where it has the potential to suppress dengue and other arboviruses. The infection was subsequently spread into two natural populations at Yorkeys Knob and Gordonvale near Cairns, Queensland in 2011. Here we report ... | 25,211,492 | [
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0.2204098,
0.01988139,... |
Circadian rhythms and sleep in bipolar disorder: implications for pathophysiology and treatment. | Multiple lines of evidence support the conceptualization of bipolar disorder as a disorder of circadian rhythms. Considering bipolar disorder in the framework of circadian disturbances also helps understand the clinical phenomenology pointing toward a multisystemic involvement. Patients with bipolar disorder show alter... | 25,211,500 | [
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0.08413926,
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0.1906059,
0.1597484,
-0.27044... |
Nanosilica-induced placental inflammation and pregnancy complications: Different roles of the inflammasome components NLRP3 and ASC. | Despite the increasing commercial use of nanoparticles, little is known about their effects on placental inflammation and pregnancy complications. In this study, nanosilica (NS) particles upregulated the inflammasome component nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain-containing ... | 25,211,550 | [
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... |
A label-free untethered approach to single-molecule protein binding kinetics. | Single molecule approaches provide rich real-time dynamics of molecular interactions that are not accessible to ensemble measurements. Previous single molecule studies have relied on labeling and tethering, which alters the natural state of the protein. Here we use the double-nanohole (DNH) optical tweezer approach to ... | 25,211,555 | [
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0.1302355,
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0... |
Exploring routine use of telemedicine through a case study in rehabilitation. | This study examines how telerehabilitation becomes part of existing and new clinical routines and identifies factors that enable or constrain its routine use. An in-depth case study of a telemedicine program in rehabilitation implemented between an urban specialized rehabilitation center and a rural regional rehabilita... | 25,211,559 | [
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0.2611306,
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0.1887143,
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-0.07219564,
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0.02538515,
0.07403316,
... |
Varicella-Zoster Virus Vasculopathy: The Growing Association Between Herpes Zoster and Strokes. | Varicella-zoster virus (VZV) is herpes virus that after its reactivation from nerve ganglia to cause herpes zoster may lead to a variety of neurologic complications, including encephalitis, meningitis, retinal necrosis or myelitis. In addition, VZV can spread to arteries in the central nervous system and cause hemorrha... | 25,211,583 | [
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0.08228976,
0.1722324,
0.0623374... |
Organocatalytic kinetic resolution of racemic secondary nitroallylic alcohols combined with simultaneous desymmetrization of prochiral cyclic anhydrides. | This study describes an organocatalytic kinetic resolution of racemic secondary nitroallylic alcohols (2) combined with simultaneous desymmetrization of prochiral cyclic anhydrides (1). The experimental results revealed that enantioselective alcoholysis of 3-substituted glutaric anhydrides afforded hemiesters (3) with ... | 25,211,598 | [
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... |
Working in partnership with patients to promote concordance with compression bandaging. | Patients may be tempted to remove their compression bandages if they find them uncomfortable, particularly at night. Working in partnership with patients to select bandages that they find tolerable and then applying them in a way that promotes comfort will encourage concordance with this therapy. | 25,211,595 | [
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0.06825628,
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-0.09106798,
0.015797... |
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