title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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A new sunscreen application technique to protect more efficiently from ultraviolet radiation. | UV radiation protection is an important health issue. Sophisticated sunscreen formulations have been developed to improve compliance. However, sunscreen is still inadequately applied, leaving large body areas without effective protection. This study aims to validate a newly developed sunscreen application technique for... | 25,215,864 | [
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Spectral-domain optical coherence tomography of emulsified subretinal silicone oil presenting as a macular inverted pseudohypopyon. | The authors present a rare case of an inverted pseudohypopyon due to subretinal emulsified silicone oil in the macula of a patient who underwent pars plana vitrectomy surgery for repair of retinal detachment with proliferative vitreoretinopathy 1 year prior to presentation of this finding. The patient’s predisposing di... | 25,215,873 | [
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Effect of body condition on tissue distribution of perfluoroalkyl substances (PFASs) in Arctic fox (Vulpes lagopus). | Arctic animals undergo large seasonal fluctuations in body weight. The effect of body condition on the distribution and composition of 16 perfluoroalkyl substances (PFASs) was investigated in liver, blood, kidney, adipose tissue, and muscle of Arctic foxes (Vulpes lagopus) from Svalbard (n = 18, age 1-3 years). PFAS co... | 25,215,880 | [
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Differential reward learning for self and others predicts self-reported altruism. | In social environments, decisions not only determine rewards for oneself but also for others. However, individual differences in pro-social behaviors have been typically studied through self-report. We developed a decision-making paradigm in which participants chose from card decks with differing rewards for themselves... | 25,215,883 | [
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Novel mucosal DNA-MVA HIV vaccination in which DNA-IL-12 plus cholera toxin B subunit (CTB) cooperates to enhance cellular systemic and mucosal genital tract immunity. | Induction of local antiviral immune responses at the mucosal portal surfaces where HIV-1 and other viral pathogens are usually first encountered remains a primary goal for most vaccines against mucosally acquired viral infections. Exploring mucosal immunization regimes in order to find optimal vector combinations and a... | 25,215,887 | [
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Comparison of hepatocellular carcinoma miRNA expression profiling as evaluated by next generation sequencing and microarray. | MicroRNA (miRNA) expression profiling has proven useful in diagnosing and understanding the development and progression of several diseases. Microarray is the standard method for analyzing miRNA expression profiles; however, it has several disadvantages, including its limited detection of miRNAs. In recent years, advan... | 25,215,888 | [
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Roles of calcium/calmodulin-dependent kinase II in long-term memory formation in crickets. | Ca(2+)/calmodulin (CaM)-dependent protein kinase II (CaMKII) is a key molecule in many systems of learning and memory in vertebrates, but roles of CaMKII in invertebrates have not been characterized in detail. We have suggested that serial activation of NO/cGMP signaling, cyclic nucleotide-gated channel, Ca(2+)/CaM and... | 25,215,889 | [
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Level IB nodal involvement in oropharyngeal carcinoma: implications for submandibular gland-sparing intensity-modulated radiotherapy. | Submandibular gland-sparing intensity-modulated radiotherapy (SMG-sparing IMRT) has been proposed to reduce xerostomia following head and neck irradiation. However, the safety of this practice has been questioned. Data from a large surgical series of oropharyngeal carcinoma patients were extracted to identify clinicopa... | 25,215,891 | [
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Nuclear factor kappa B and cyclo-oxygenase-2: two concordant players in psoriasis pathogenesis. | Nuclear factor kappa B (NFκB) is a key regulatory element in a variety of immune and inflammatory pathways, cellular proliferation, differentiation and apoptosis. Cyclo-oxygenase 2 (COX2) is one of the downstream targets of NFκB. The current work aimed to explore the possible role of NFκB and COX2 in psoriasis pathogen... | 25,215,902 | [
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The ASEAN economic community and medical qualification. | In the regional movement toward ASEAN Economic Community (AEC), medical professions including physicians can be qualified to practice medicine in another country. Ensuring comparable, excellent medical qualification systems is crucial but the availability and analysis of relevant information has been lacking. This stud... | 25,215,908 | [
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Barriers to health care among people with disabilities who are members of underserved racial/ethnic groups: a scoping review of the literature. | Understanding barriers to health care access experienced by people with disabilities who are members of underserved racial/ethnic groups is key to developing interventions to improve access. To conduct a scoping review of the literature to examine the published literature on barriers to health care access for people wi... | 25,215,920 | [
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Spatial distance effects on incremental semantic interpretation of abstract sentences: evidence from eye tracking. | A large body of evidence has shown that visual context information can rapidly modulate language comprehension for concrete sentences and when it is mediated by a referential or a lexical-semantic link. What has not yet been examined is whether visual context can also modulate comprehension of abstract sentences increm... | 25,215,930 | [
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AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1. | Damaged mitochondria are eliminated by mitophagy, a selective form of autophagy whose dysfunction associates with neurodegenerative diseases. PINK1, PARKIN and p62/SQTMS1 have been shown to regulate mitophagy, leaving hitherto ill-defined the contribution by key players in 'general' autophagy. In basal conditions, a po... | 25,215,947 | [
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Targeting proapoptotic protein BAD inhibits survival and self-renewal of cancer stem cells. | Emerging evidence suggests that the resistance of cancer stem cells (CSC) to many conventional therapies is one of the major limiting factors of cancer therapy efficacy. Identification of mechanisms responsible for survival and self-renewal of CSC will help design new therapeutic strategies that target and eliminate bo... | 25,215,949 | [
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Intraoperative examination of sentinel lymph nodes using scrape cytology. | Background. In breast cancer, sentinel lymph node biopsy (SLNB) is widely used to assess the axilla when the nodes appear normal on palpation and ultrasonography. When the sentinel lymph nodes (SLNs) are negative, no further dissection is required. Surgical dissection or radiotherapy of the axilla is indicated for macr... | 25,215,952 | [
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Applying the simplest Kochen-Specker set for quantum information processing. | Kochen-Specker (KS) sets are key tools for proving some fundamental results in quantum theory and also have potential applications in quantum information processing. However, so far, their intrinsic complexity has prevented experimentalists from using them for any application. The KS set requiring the smallest number o... | 25,215,966 | [
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Constraining the equation of state of neutron stars from binary mergers. | Determining the equation of state of matter at nuclear density and hence the structure of neutron stars has been a riddle for decades. We show how the imminent detection of gravitational waves from merging neutron star binaries can be used to solve this riddle. Using a large number of accurate numerical-relativity simu... | 25,215,972 | [
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Matrix product states for gauge field theories. | The matrix product state formalism is used to simulate Hamiltonian lattice gauge theories. To this end, we define matrix product state manifolds which are manifestly gauge invariant. As an application, we study (1+1)-dimensional one flavor quantum electrodynamics, also known as the massive Schwinger model, and are able... | 25,215,973 | [
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Hindered Gamow-Teller decay to the odd-odd N=Z (62)Ga: absence of proton-neutron T=0 condensate in A=62. | Search for a new kind of superfluidity built on collective proton-neutron pairs with aligned spin is performed studying the Gamow-Teller decay of the T=1, J(π)=0+ ground state of (62)Ge into excited states of the odd-odd N=Z nucleus (62)Ga. The experiment is performed at GSI Helmholtzzentrum für Shwerionenforshung with... | 25,215,980 | [
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Microbunching instability in relativistic electron bunches: direct observations of the microstructures using ultrafast YBCO detectors. | Relativistic electron bunches circulating in accelerators are subjected to a dynamical instability leading to microstructures at millimeter to centimeter scale. Although this is a well-known fact, direct experimental observations of the structures, or the field that they emit, remained up to now an open problem. Here, ... | 25,215,987 | [
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Observation of a disordered bosonic insulator from weak to strong interactions. | We employ ultracold atoms with controllable disorder and interaction to study the paradigmatic problem of disordered bosons in the full disorder-interaction plane. Combining measurements of coherence, transport and excitation spectra, we get evidence of an insulating regime extending from weak to strong interaction and... | 25,215,990 | [
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Atomistic explanation of shear-induced amorphous band formation in boron carbide. | Boron carbide (B4C) is very hard, but its applications are hindered by stress-induced amorphous band formation. To explain this behavior, we used density function theory (Perdew-Burke-Ernzerhof flavor) to examine the response to shear along 11 plausible slip systems. We found that the (0111)/<1101> slip system ha... | 25,215,991 | [
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Revealing the structure of a granular medium through ballistic sound propagation. | We study the propagation of sound through a bidimensional granular medium consisting of photoelastic disks, which are packed into different crystalline and disordered structures. Acoustic sensors placed at the boundaries of the system capture the acoustic signal produced by a local and well-controlled mechanical excita... | 25,216,006 | [
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Inherent variability in the kinetics of autocatalytic protein self-assembly. | In small volumes, the kinetics of filamentous protein self-assembly is expected to show significant variability, arising from intrinsic molecular noise. This is not accounted for in existing deterministic models. We introduce a simple stochastic model including nucleation and autocatalytic growth via elongation and fra... | 25,216,007 | [
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Stochastic accumulation by cortical columns may explain the scalar property of multistable perception. | The timing of certain mental events is thought to reflect random walks performed by underlying neural dynamics. One class of such events--stochastic reversals of multistable perceptions--exhibits a unique scalar property: even though timing densities vary widely, higher moments stay in particular proportions to the mea... | 25,216,009 | [
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Targeting CD36-mediated inflammation reduces acute brain injury in transient, but not permanent, ischemic stroke. | The pathology of stroke consists of multiple pro-death processes, and CD36 has been suggested as a multimodal target to reduce oxidative stress and inflammation in ischemic stroke. Using CD36-deficient mice and SS-31, a cell permeable tetrapeptide known to down-regulate CD36 pathways, the current study investigated whe... | 25,216,018 | [
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Intercropping enhances soil carbon and nitrogen. | Intercropping, the simultaneous cultivation of multiple crop species in a single field, increases aboveground productivity due to species complementarity. We hypothesized that intercrops may have greater belowground productivity than sole crops, and sequester more soil carbon over time due to greater input of root litt... | 25,216,023 | [
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Regression of a paraganglioma tumor of the orbit. | To describe a clinical case of an orbital paraganglioma that displayed regression after biopsy alone. Case report. A 75-year-old female was examined for a right orbital tumor suspected to be metastatic breast carcinoma. An orbital biopsy was performed with significant hemorrhage encountered requiring extensive cautery.... | 25,216,041 | [
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Eukaryotic initiation factor 5A plays an essential role in luteinizing hormone receptor regulation. | Down-regulation of LH receptor (LHR) in the ovary by its ligand is mediated by a specific RNA-binding protein, designated LH receptor mRNA-binding protein (LRBP), through translational suppression and mRNA degradation. Using yeast 2-hybrid screens, we previously identified eukaryotic initiation factor 5A (eIF5A) as one... | 25,216,047 | [
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Rapoport's rule revisited: geographical distributions of human languages. | One of the most well studied ecological patterns is Rapoport's rule, which posits that the geographical extent of species ranges increases at higher latitudes. However, studies to date have been limited in their geographic scope and results have been equivocal. In turn, much debate exists over potential links between R... | 25,216,049 | [
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Conjunct SEP and MEP monitoring in resection of infratentorial lesions: lessons learned in a cohort of 210 patients. | During the surgical removal of infratentorial lesions, intraoperative neuromonitoring is mostly focused on cranial nerve assessment and brainstem auditory potentials. Despite the known risk of perforating vessel injury during microdissection within the vicinity of the brainstem, there are few reports about intraoperati... | 25,216,065 | [
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Different mechanisms for role relations versus verb-action congruence effects: evidence from ERPs in picture-sentence verification. | Extant accounts of visually situated language processing do make general predictions about visual context effects on incremental sentence comprehension; these, however, are not sufficiently detailed to accommodate potentially different visual context effects (such as a scene-sentence mismatch based on actions versus th... | 25,216,075 | [
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Carbon flow from volcanic CO2 into soil microbial communities of a wetland mofette. | Effects of extremely high carbon dioxide (CO2) concentrations on soil microbial communities and associated processes are largely unknown. We studied a wetland area affected by spots of subcrustal CO2 degassing (mofettes) with focus on anaerobic autotrophic methanogenesis and acetogenesis because the pore gas phase was ... | 25,216,086 | [
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Di-, tri-, and tetranuclear copper(I) complexes of phenanthroline-linked dicarbene ligands. | A family of 2,9-di(3-R-1H-imidazolium-1-yl)-1,10-phenanthroline iodides and hexafluorophosphates (R = allyl, benzyl, mesityl, picolyl) were synthesized from 2,9-diiodophenanthroline and imidazole or N-substituted imidazoles. Simple reactions of these diimidazolium salts with copper powder at room temperature have affor... | 25,216,090 | [
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Induction of body weight loss through RNAi-knockdown of APOBEC1 gene expression in transgenic rabbits. | In the search of new strategies to fight against obesity, we targeted a gene pathway involved in energy uptake. We have thus investigated the APOB mRNA editing protein (APOBEC1) gene pathway that is involved in fat absorption in the intestine. The APOB gene encodes two proteins, APOB100 and APOB48, via the editing of a... | 25,216,115 | [
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Anatomical study of the pterygomaxillary area for implant placement: cone beam computed tomographic scanning in 100 patients. | The aim of this study was to describe the average angulation and dimensions of the pterygomaxillary area in the atrophic maxilla to facilitate the orientation of pterygoid implants during their placement. A retrospective radiologic study was made. A virtual pterygoid implant, 13, 15, or 18 mm long, was placed in the pt... | 25,216,128 | [
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Accuracy of positioning of implants inserted using a mucosa-supported stereolithographic surgical guide in the edentulous maxilla and mandible. | The aim of this study was to evaluate the accuracy of implants inserted using a mucosa-supported stereolithographic surgical guide and to determine the influence of surgical management of the guide (fixed or unfixed), arch (maxilla or mandible), and smoking habit (normal or hyperplastic mucosa) on accuracy. In complete... | 25,216,132 | [
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In vitro comparison of the retentive properties of ball and locator attachments for implant overdentures. | To compare the retentive properties of ball and locator attachments during 5,000 insertion-separation cycles, corresponding to approximately 4.5 years of clinical use. Four dental implants (diameter, 3.8 mm; length, 12 mm) were inserted into the prepared beds of two polyethylene blocks. Twenty acrylic prosthetic compon... | 25,216,136 | [
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Esthetic outcome evaluation of maxillary anterior single-tooth bone-level implants with metal or ceramic abutments and ceramic crowns. | The aim of this study was to evaluate the treatment outcome of implants placed in the maxillary anterior segment. Patients were treated with bone-level implants (Straumann Bone Level Implant, Institut Straumann) that supported all-ceramic single crowns and were followed for 2 to 4 years. Titanium or ceramic abutments w... | 25,216,139 | [
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The prevalence of hearing loss in South Korea: data from a population-based study. | In the present study, we aimed to determine the prevalence of hearing loss in the South Korean population and to understand the correlation between aging, sex, and hearing loss prevalence through the analysis of data collected from the Korea National Health and Nutrition Examination Survey (KNHANES). Cross-sectional ep... | 25,216,153 | [
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Mapping ergonomics application to improve SMEs working condition in industrially developing countries: a critical review. | In industrially developing countries (IDC), small and medium enterprises (SMEs) account for the highest proprotion of employment. Unfortunately, the working conditions in SMEs are often very poor and expose employees to a potentially wide range of health and safety risks. This paper presents a comprehensive review of 1... | 25,216,158 | [
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Measurement of cooling detection thresholds for identification of diabetic sensorimotor polyneuropathy in type 1 diabetes. | Compared to recently-studied novel morphological measures, conventional small nerve fiber functional tests have not been systematically studied for identification of diabetic sensorimotor polyneuropathy (DSP). We aimed to determine and compare the diagnostic performance of cooling detection thresholds (CDT) in a cross-... | 25,216,179 | [
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Stochastic optimal foraging: tuning intensive and extensive dynamics in random searches. | Recent theoretical developments had laid down the proper mathematical means to understand how the structural complexity of search patterns may improve foraging efficiency. Under information-deprived scenarios and specific landscape configurations, Lévy walks and flights are known to lead to high search efficiencies. Ba... | 25,216,191 | [
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Polypyrrole-montmorillonite nanocomposite as sorbent for solid-phase microextraction of phenolic compounds in water. | A fiber-coated polypyrrole-montmorillonite nanocomposite was prepared for solid-phase microextraction. The fiber coating can be prepared easily; it is mechanically stable and exhibits relatively high thermal stability. The prepared fiber was evaluated for the extraction of some phenolic compounds from aqueous sample so... | 25,216,242 | [
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Polymer collapse in miscible good solvents is a generic phenomenon driven by preferential adsorption. | Water and alcohol, such as methanol or ethanol, are miscible and, individually, good solvents for poly(N-isopropylacrylamide) (PNIPAm), but this polymer precipitates in water-alcohol mixtures. The intriguing behaviour of solvent mixtures that cannot dissolve a given polymer or a given protein, while the same macromolec... | 25,216,245 | [
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Repeatability of feather mite prevalence and intensity in passerine birds. | Understanding why host species differ so much in symbiont loads and how this depends on ecological host and symbiont traits is a major issue in the ecology of symbiosis. A first step in this inquiry is to know whether observed differences among host species are species-specific traits or more related with host-symbiont... | 25,216,248 | [
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Sheep lung segmental delivery strategy demonstrates adenovirus priming of local lung responses to bacterial LPS and the role of elafin as a response modulator. | Viral lung infections increase susceptibility to subsequent bacterial infection. We questioned whether local lung administration of recombinant adenoviral vectors in the sheep would alter the susceptibility of the lung to subsequent challenge with bacterial lipopolysaccharide (LPS). We further questioned whether local ... | 25,216,250 | [
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EMF monitoring-concepts, activities, gaps and options. | Exposure to electromagnetic fields (EMF) is a cause of concern for many people. The topic will likely remain for the foreseeable future on the scientific and political agenda, since emissions continue to change in characteristics and levels due to new infrastructure deployments, smart environments and novel wireless de... | 25,216,256 | [
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Stable nonaromatic [20]dithiaporphyrin (2.1.1.1) macrocycles: synthesis, structure, spectral, electrochemical, and metal ion sensing studies. | Stable nonaromatic [20]dithiaporphyrin (2.1.1.1) macrocycles were synthesized in decent yields by condensing readily available butene-2,3-diyl-bisthiophene-2,5-diyl-bis(p-methoxyphenylmethanol) with different meso-aryl dipyrromethanes under mild acid-catalyzed conditions. The [20]dithiaporphyrin (2.1.1.1) macrocycles a... | 25,216,279 | [
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Estrogen stimulates the invasion of ovarian cancer cells via activation of the PI3K/AKT pathway and regulation of its downstream targets E‑cadherin and α‑actinin‑4. | Previous studies by our group revealed that the phosphoinositide 3‑kinase (PI3K)/AKT pathway was involved in estrogen‑induced metastasis in ovarian cancer cells. In the present study, the role and mechanism of estrogen‑induced invasion was further explored using a stable short hairpin RNA (shRNA) estrogen receptor α/β ... | 25,216,292 | [
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Forest stand growth dynamics in Central Europe have accelerated since 1870. | Forest ecosystems have been exposed to climate change for more than 100 years, whereas the consequences on forest growth remain elusive. Based on the oldest existing experimental forest plots in Central Europe, we show that, currently, the dominant tree species Norway spruce and European beech exhibit significantly fas... | 25,216,297 | [
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Odour enrichment increases adult-born dopaminergic neurons in the mouse olfactory bulb. | The olfactory bulb (OB) is the first brain region involved in the processing of olfactory information. In adult mice, the OB is highly plastic, undergoing cellular/molecular dynamic changes that are modulated by sensory experience. Odour deprivation induces down-regulation of tyrosine hydroxylase (TH) expression in OB ... | 25,216,299 | [
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Pharmacology, physiology, and mechanisms of action of dipeptidyl peptidase-4 inhibitors. | Dipeptidyl peptidase-4 (DPP4) is a widely expressed enzyme transducing actions through an anchored transmembrane molecule and a soluble circulating protein. Both membrane-associated and soluble DPP4 exert catalytic activity, cleaving proteins containing a position 2 alanine or proline. DPP4-mediated enzymatic cleavage ... | 25,216,328 | [
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Agenesia of the left atrial appendage: possible but very rare. | : Agenesia of the left atrial appendage in a patient with atrial fibrillation is shown. Although of interest, the prevalence of this abnormality is very low. | 25,216,332 | [
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Cognitive and neuropsychological underpinnings of relational and conjunctive working memory binding across age. | The ability to form associations (i.e., binding) is critical for memory formation. Recent studies suggest that aging specifically affects relational binding (associating separate features) but not conjunctive binding (integrating features within an object). Possibly, this dissociation may be driven by the spatial natur... | 25,216,357 | [
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Determinants of functional disability in Huntington's disease: role of cognitive and motor dysfunction. | The clinical syndrome of Huntington's disease (HD) is notable for a triad of motor, cognitive, and emotional features. All HD patients eventually become occupationally disabled; however, the factors that render HD patients unable to maintain employment have not been extensively studied. This review begins by discussing... | 25,216,368 | [
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Animal models of Huntington's disease for translation to the clinic: best practices. | Mouse models of Huntington's disease (HD) recapitulate many aspects of the human disease. These genetically modified mice are powerful tools that are used not only to examine the pathogenesis of the disease, but also to assess the efficacy of potential new treatments. Disappointingly, in the past few years we have seen... | 25,216,369 | [
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Clinical trials in Huntington's disease: Interventions in early clinical development and newer methodological approaches. | Since the identification of the Huntington's disease (HD) gene, knowledge has accumulated about mechanisms directly or indirectly affected by the mutated Huntingtin protein. Transgenic and knock-in animal models of HD facilitate the preclinical evaluation of these targets. Several treatment approaches with varying, but... | 25,216,371 | [
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Competitive coordination control of the AIE and micro states of supramolecular gel: an efficient approach for reversible dual-channel stimuli-response materials. | An organogelator (G2) based on multi self-assembly driving forces, fluorescent signal groups and coordination binding sites was designed and synthesized. G2 could form a stable Cd(2+)-coordinated supramolecular metallogel (CdG) accompanied by strong brilliant blue aggregation-induced fluorescence emission (AIE). By the... | 25,216,393 | [
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Changes in the frequencies of abdominal wall hernias and the preferences for their repair: a multicenter national study from Turkey. | Abdominal wall hernias are a common problem in the general population. A Western estimate reveals that the lifetime risk of developing a hernia is about 2%. As a result, hernia repairs likely comprise the most frequent general surgery operations. More than 20 million hernias are estimated to be repaired every year arou... | 25,216,417 | [
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Giant inguinoscrotal hernia--report of a rare case with literature review. | Massive inguinoscrotal hernias extending below the midpoint of the inner thigh, in the standing position constitute giant inguinoscrotal hernias. We report a patient who presented with giant right inguinal hernia with bilateral hydrocele for 25 years. He had no cardiorespiratory illnesses. He was taken up for surgery u... | 25,216,421 | [
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Resorbable synthetic mesh supported with omentum flap in the treatment of giant hiatal hernia. | Covering a large hiatal hernia with a mesh has become a basic procedure in the last few years. However, mesh implants are associated with high complication rates (esophageal erosion, perforation, fistula, etc.). We propose using a synthetic resorbable mesh supported with an omental flap as a possible solution to this p... | 25,216,419 | [
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Use of stapling devices for safe cholecystectomy in acute cholecystitis. | Many techniques are described for the ligation of a difficult cystic duct (CD). The aim of this study is to assess the effectiveness and safety of stapling of a difficult CD in acute cholecystitis using Endo-GIA. From January 2008 to June 2012, 1441 patients with cholelithiasis underwent laparoscopic cholecystectomy (L... | 25,216,423 | [
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Tissue management with tri-staple technology in major and minor laparoscopic liver resections. | One of the most relevant technologic advancements in laparoscopic liver resection (LLR) is owing to the improved ability to safely secure and divide vascular and biliary structures and the liver parenchyma by the use of endostaplers. We compared, retrospectively, 35 LLRs with the Tri-Staple technology versus 57 LLRs wi... | 25,216,429 | [
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The combination application of space filling and closed irrigation suction in reconstruction of sacral decubitus ulcer. | Dead space and poor drainage are the main reasons for intractable sacral decubitus ulcers. The objective of this study was to investigate the effects of treatment for sacral decubitus ulcer using space filling through muscle flap and closed irrigation. A total of 22 patients with serious sacral decubitus ulcer were tre... | 25,216,432 | [
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Disability-adjusted life years (DALYs) in general population with pelvic organ prolapse: a study based on the prolapse quality-of-life questionnaire (P-QOL). | To evaluate the impact of pelvic organ prolapse (POP) on quality of life in symptomatic and asymptomatic women. This is a cross-sectional study in a general population of adult women. Symptomatic and asymptomatic women with POP were studied. Symptomatic women were defined as those who reported the presence/feeling of l... | 25,216,448 | [
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Spatial-temporal model for silencing of the mitotic spindle assembly checkpoint. | The spindle assembly checkpoint arrests mitotic progression until each kinetochore secures a stable attachment to the spindle. Despite fluctuating noise, this checkpoint remains robust and remarkably sensitive to even a single unattached kinetochore among many attached kinetochores; moreover, the checkpoint is silenced... | 25,216,458 | [
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Highly selective and sensitive optical sensor for determination of Pb2+ and Hg2+ ions based on the covalent immobilization of dithizone on agarose membrane. | A highly sensitive and selective optical membrane for determination of Hg(2+) and Pb(2+) was prepared by covalent immobilization of dithizone on agarose membrane. In addition to its high stability, reproducibility and relatively long lifetime, the proposed optical sensor revealed good selectivity for target ions over a... | 25,216,460 | [
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Immediate and mid-term effects of pyrimethanil toxicity on microalgae by simulating an episodic contamination. | Since pesticides can represent a threat for non-target aquatic communities, including microalgae, we looked at the effects of the fungicide pyrimethanil on the growth of the freshwater green microalgae Selenastrum capricornutum. Additionally, attenuation of the toxicity of pyrimethanil due to its dissipation in the wat... | 25,216,469 | [
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Multilayer surface albedo for face recognition with reference images in bad lighting conditions. | In this paper, we propose a multilayer surface albedo (MLSA) model to tackle face recognition in bad lighting conditions, especially with reference images in bad lighting conditions. Some previous researches conclude that illumination variations mainly lie in the large-scale features of an image and extract small-scale... | 25,216,483 | [
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Multispectral photometric stereo for acquiring high-fidelity surface normals. | Multispectral imaging and photometric stereo are common in 3D imaging but rarely have been combined. Reconstructing a 3D object's shape using photometric stereo is challenging owing to indirect illumination, specular reflection, and self-shadows, and removing interreflection in photometric stereo is problematic. A new ... | 25,216,479 | [
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Distributed Cooperative Optimal Control for Multiagent Systems on Directed Graphs: An Inverse Optimal Approach. | In this paper, the inverse optimal approach is employed to design distributed consensus protocols that guarantee consensus and global optimality with respect to some quadratic performance indexes for identical linear systems on a directed graph. The inverse optimal theory is developed by introducing the notion of parti... | 25,216,491 | [
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Approximation-Based Discrete-Time Adaptive Position Tracking Control for Interior Permanent Magnet Synchronous Motors. | This paper considers the problem of discrete-time adaptive position tracking control for a interior permanent magnet synchronous motor (IPMSM) based on fuzzy-approximation. Fuzzy logic systems are used to approximate the nonlinearities of the discrete-time IPMSM drive system which is derived by direct discretization us... | 25,216,493 | [
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Aminoglycoside-induced damage in the statocyst of the longfin inshore squid, Doryteuthis pealeii. | Squid are a significant component of the marine biomass and are a long-established model organism in experimental neurophysiology. The squid statocyst senses linear and angular acceleration and is the best candidate for mediating squid auditory responses, but its physiology and morphology are rarely studied. The statoc... | 25,216,502 | [
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Enteric pathogens and cellular transformation: bridging the gaps. | Cancer patients in general, either due to the nature of their underlying illness or because of being on chemotherapeutic regimens, are at increased risk of infection. Indeed, microbes can exploit the innate plasticity of the epithelial cells to promote their trans-differentiation into a mesenchymal phenotype in a proce... | 25,216,513 | [
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RASAL2 down-regulation in ovarian cancer promotes epithelial-mesenchymal transition and metastasis. | Ovarian cancer is the most lethal gynecologic malignancy, and transcoelomic metastasis is responsible for the greatest disease mortality. Although intensive efforts have been made, the mechanism behind this process remains unclear. RASAL2 is a GTPase activating proteins (GAPs) which was recently reported as a tumor sup... | 25,216,515 | [
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Pharmacokinetics of imipenem in critically ill patients during empirical treatment of nosocomial pneumonia: a comparison of 0.5-h and 3-h infusions. | In critically ill patients, pathophysiological changes alter the pharmacokinetics of antibiotics. Imipenem exhibits primarily time-dependent killing. Its administration by prolonged infusion may increase the time for which its plasma concentration exceeds the minimum inhibitory concentrations (MICs) of suspected pathog... | 25,216,543 | [
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Complexity measures for the evolutionary categorization of organisms. | Complexity measures are used to compare the genomic characteristics of five organisms belonging to distinct classes spanning the evolutionary tree: higher eukaryotes, amoebae, unicellular eukaryotes and bacteria. The comparisons are undertaken using the full four-letter alphabet and the coarse grained two-letter alphab... | 25,216,557 | [
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COMT met allele differentially predicts risk versus severity of aberrant eating in a large community sample. | Prefrontal dopamine (DA) transmission participates in the reinforcement of reward-driven behaviors like eating. Because catechol-O-methyltransferase (COMT) degrades DA and is expressed in the prefrontal cortex, variation in the COMT gene may modulate eating behavior. Previous studies have shown that the met allele of t... | 25,216,558 | [
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Attentional biases to body shape images in adolescents with anorexia nervosa: an exploratory eye-tracking study. | Body image distortion (BID) plays an important role in the etiology and maintenance of anorexia nervosa (AN). Previous studies of BID in AN showed small biases in visual scanning behavior (VSB) towards images of body shapes. The aim of this study is to investigate biases in VSB when body shape images compete with image... | 25,216,561 | [
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Human papillomavirus type 16 E7 oncoprotein causes a delay in repair of DNA damage. | Patients with human papillomavirus related (HPV+) head and neck cancers (HNCs) demonstrate improved clinical outcomes compared to traditional HPV negative (HPV-) HNC patients. We have recently shown that HPV+ HNC cells are more sensitive to radiation than HPV- HNC cells. However, roles of HPV oncogenes in regulating th... | 25,216,575 | [
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Autophagy regulates amyotrophic lateral sclerosis-linked fused in sarcoma-positive stress granules in neurons. | Mutations in fused in sarcoma (FUS), a DNA/RNA binding protein, have been associated with familial amyotrophic lateral sclerosis (fALS), which is a fatal neurodegenerative disease that causes progressive muscular weakness and has overlapping clinical and pathologic characteristics with frontotemporal lobar degeneration... | 25,216,585 | [
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Hemodynamic and metabolic effects of estrogen plus progestin therapy in hypertensive postmenopausal women treated with an ACE-inhibitor or a diuretic. | The aim of the study was to assess the hemodynamic and metabolic actions of estrogen plus progestin therapy (EPT) in hypertensive, postmenopausal women treated with perindopril (ACEI) or hydrochlorothiazide (HCTZ). A group of normotensive postmenopausal women was also studied. 100 hypertensive and 40 normotensive postm... | 25,216,597 | [
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Advances in percutaneous coronary interventions for elderly patients. | Coronary heart disease (CHD) is one of the leading causes of morbidity and the most common cause of death in older adults. Paradoxically, elderly patients tend to be systematically excluded from randomized-controlled cardiovascular trials, which complicates decision-making in this population. Management of CHD in the e... | 25,216,617 | [
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Postoperative nomogram to predict the probability of metastasis in Enneking stage IIB extremity osteosarcoma. | Metastasis is the most crucial prognostic factor in osteosarcoma. The goal of this study was to develop a new nomogram to predict the probability of metastasis in Enneking stage IIB extremity osteosarcoma after neoadjuvant chemotherapy and limb salvage surgery. We examined medical records of 91 patients who had undergo... | 25,216,622 | [
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0.0492... |
Risk stratification in very old adults: how to best gauge risk as the basis of management choices for patients aged over 80. | Cardiovascular disease (CVD) is the leading cause of mortality in older adults, however, in the elderly accurate stratification of CVD risk to guide management decisions is challenging due to the heterogeneity of the population. Conventional assessment of CVD and therapeutic risk is based on extrapolation of guidelines... | 25,216,619 | [
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Effect of manganese supplementation on the membrane integrity and the mitochondrial potential of the sperm of grazing Nelore bulls. | The effect of dietary manganese (Mn(2+)) supplementation on the reproductive performance of Nelore bulls was evaluated by assessment of sperm membrane integrity. Sixty Nelore bulls (Bos taurus indicus) aged 18-20 mo were randomly divided into four groups (n=15) receiving dietary Mn(2+) supplementation at 540, 1300, 380... | 25,216,627 | [
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Trigonal versus extratrigonal botulinum toxin-A: a systematic review and meta-analysis of efficacy and adverse events. | Botulinum toxin-A (BoNT-A) is a potent neurotoxin that is an effective treatment for patients with pharmacologically refractory detrusor overactivity (DO). Data assessing the effectiveness of trigonal BoNT-A are limited. This study evaluates adverse events (AEs) and short-term efficacy associated with trigonal and extr... | 25,216,630 | [
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One-step integration of multiple genes into the oleaginous yeast Yarrowia lipolytica. | Yarrowia lipolytica is an unconventional yeast, and is generally recognized as safe (GRAS). It provides a versatile fermentation platform that is used commercially to produce many added-value products. Here we report a multiple fragment assembly method that allows one-step integration of an entire β-carotene biosynthes... | 25,216,641 | [
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0.4505064,
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Atrial and ventricular specification of ADSCs is stimulated by different doses of BMP4. | To investigate the effect of BMP4 on cardiomyocyte differentiation of adipose tissue-derived stem cells (ADSCs), mouse ADSCs were treated with different concentrations of BMP4 in media containing fetal bovine serum (FBS) or Knockout™ Serum Replacement (KoSR). 3 weeks after cardiac induction, differentiated ADSCs expres... | 25,216,643 | [
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Cloning, homology modeling, and reaction mechanism analysis of a novel cis-epoxysuccinate hydrolase from Klebsiella sp. | The gene encoding a novel cis-epoxysuccinate hydrolase, which hydrolyzes cis-epoxysuccinate to L (+)-tartaric acid, was cloned from Klebsiella sp. BK-58 and expressed in Escherichia coli. The ORF was 825 bp encoding a mature protein of 274 amino acids with a molecular mass of 30.1 kDa. Multiple sequence alignment showe... | 25,216,644 | [
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The posterior parietal cortex (PPC) mediates anticipatory motor control. | Flexible and precisely timed motor control is based on functional interaction within a cortico-subcortical network. The left posterior parietal cortex (PPC) is supposed to be crucial for anticipatory motor control by sensorimotor feedback matching. Intention of the present study was to disentangle the specific relevanc... | 25,216,648 | [
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Association between low 25-hydroxyvitamin D, insulin resistance and arterial stiffness in nondiabetic women with systemic lupus erythematosus. | The objective of this paper is to examine if there is an association between low levels of 25-hydroxyvitamin D (25(OH)D) and insulin resistance (IR) in nondiabetic women with systemic lupus erythematosus (SLE) and to evaluate its impact on arterial stiffness. In this cross-sectional study 25(OH)D, insulin, insulin resi... | 25,216,653 | [
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Organizational aspects of primary care related to avoidable hospitalization: a systematic review. | Often used indicators for the quality of primary care are hospital admissions rates for conditions which are potentially avoidable by well-functioning primary care. Such hospitalizations are frequently termed as ambulatory care sensitive conditions (ACSCs). We aim to investigate which characteristics of primary care or... | 25,216,664 | [
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Alternative diagnoses in patients in whom the GP considered the diagnosis of pulmonary embolism. | Pulmonary embolism (PE) often presents with nonspecific symptoms and may be an easily missed diagnosis. When the differential diagnosis includes PE, an empirical list of frequently occurring alternative diagnoses could support the GP in diagnostic decision making. To identify common alternative diagnoses in patients in... | 25,216,665 | [
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Non-fatal work-related traumatic brain injuries treated in US hospital emergency departments, 1998-2007. | Little is known about work-related traumatic brain injuries (WRTBI). This study describes non-fatal WRTBIs treated in US emergency departments (ED) from 1998 through 2007. Non-fatal WRTBIs were identified from the National Electronic Injury Surveillance System occupational supplement (NEISS-Work) using the diagnoses of... | 25,216,672 | [
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tRNAs: new tricks from old dogs. | tRNA biology has lately seen a revival with the discovery of tRNA cleavage products as mediators of stress responses. In this issue of The EMBO Journal, Blanco et al now report that tRNA methylation, by protecting from cleavage, is relevant for normal brain development. The versatility of tRNA is further emphasized by ... | 25,216,676 | [
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0.04439005,
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Newly antibacterial and antiadhesive lipopeptide biosurfactant secreted by a probiotic strain, Propionibacterium freudenreichii. | A lipopeptide biosurfactant production from a probiotic type strain of Propionibacterium freudenreichii subsp. freudenreichii is being reported here for the first time. This biosurfactant is able to reduce the surface tension of water from 72 to 38 mN/m with an increase of the biosurfactant concentration up to critical... | 25,216,696 | [
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Replication fork recovery and regulation of common fragile sites stability. | The acquisition of genomic instability is a triggering factor in cancer development, and common fragile sites (CFS) are the preferential target of chromosomal instability under conditions of replicative stress in the human genome. Although the mechanisms leading to CFS expression and the cellular factors required to su... | 25,216,703 | [
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Current status of viroid taxonomy. | Viroids are the smallest autonomous infectious nucleic acids known so far. With a small circular RNA genome of about 250-400 nt, which apparently does not code for any protein, viroids replicate and move systemically in host plants. Since the discovery of the first viroid almost forty-five years ago, many different vir... | 25,216,773 | [
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0.08585975,
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0.0806139,
0.3837653,
-0.4098411,
... |
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