title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Comparative study of dynamics in glass forming mixtures of Debye-type N-ethylacetamide with water, alcohol, and amine. | The glass transition and relaxation dynamics in the binary mixtures of a Debye liquid, N-ethylacetamide, with water, monoalcohol, and amine are studied by calorimetric and dielectric measurements in the highly viscous regimes near the glass transition. Calorimetric measurements show the glass transition temperature in ... | 25,217,936 | [
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Thermal conductivity of halide solid solutions: measurement and prediction. | The composition dependence of the lattice thermal conductivity in NaCl-KCl solid solutions has been measured as a function of composition and temperature. Samples with systematically varied compositions were prepared and the laser flash technique was used to determine the thermal diffusivity from 373 K to 823 K. A theo... | 25,217,938 | [
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Effect of physical aging on Johari-Goldstein relaxation in La-based bulk metallic glass. | The influence of physical aging on the β relaxation in La60Ni15Al25 bulk metallic glass has been investigated by mechanical spectroscopy. The amplitude of the β relaxation (ΔG″) decreases while its relaxation time (τ(β)) increases during aging. We find that, as in organic glasses, the changes of ln (τ(β)) and ln (ΔG(ma... | 25,217,940 | [
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Molecular simulation study of role of polymer-particle interactions in the strain-dependent viscoelasticity of elastomers (Payne effect). | The strain-amplitude dependence of viscoelastic behavior of model crosslinked elastomers containing various concentrations of spherical nanoparticles (NPs) was studied by non-equilibrium molecular dynamics simulation. All the filler NPs were in monodispersed state and the interactions between these particles were purel... | 25,217,945 | [
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Excluded volume effects in polymer brushes at moderate chain stretching. | We develop a strong stretching approximation for a polymer brush made of self-avoiding polymer chains. The density profile of the brush and the distribution of the end monomer positions in stretching direction are computed and compared with simulation data. We find that our approach leads to a clearly better approximat... | 25,217,946 | [
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Effects of truncating van der Waals interactions in lipid bilayer simulations. | In membrane simulations, it is known that truncating electrostatic interactions results in artificial ordering of lipids at the truncation distance. However, less attention has been paid to the effect of truncating van der Waals (VDW) interactions. Since the VDW potential decays as r(-6), it is frequently neglected bey... | 25,217,953 | [
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HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants. | Pancreatitis occurs in approximately 4% of patients treated with the thiopurines azathioprine or mercaptopurine. Its development is unpredictable and almost always leads to drug withdrawal. We identified patients with inflammatory bowel disease (IBD) who had developed pancreatitis within 3 months of starting these drug... | 25,217,962 | [
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Utilizing the extent of theta-gamma synchronization to estimate visuospatial memory ability. | The ability of human memory declines due to normal aging and cognitive diseases, which means that everyone will eventually be affected by this problem. Fortunately, memory ability can be improved by training, and early detection and treatment can even actively prevent serious memory loss. Based on this principle, we ai... | 25,217,964 | [
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A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer. | Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of > 10 million SNPs in 43,303 prostate cancer cases and 43,737 co... | 25,217,961 | [
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Establishing sustainable performance-based incentive schemes: views of rural health workers from qualitative research in three sub-Saharan African countries. | Performance-based incentives (PBIs) are currently receiving attention as a strategy for improving the quality of care that health providers deliver. Experiences from several African countries have shown that PBIs can trigger improvements, particularly in the area of maternal and neonatal health. The involvement of heal... | 25,217,978 | [
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The loss of CD34+ cells in peripheral hematopoietic stem cell products cryopreserved by non-controlled rate freezing and stored at -80 °C after overnight storage. | Although peripheral blood stem cell (PBSC) products cryopreserved by non-controlled rate freezing and stored at -80 °C after overnight storage are used frequently, data regarding the rate of loss of CD34+ cells in these products are limited. In this prospective study, CD34+ cells were counted at three (fresh, post-over... | 25,217,992 | [
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Chondrolysis after hip arthroscopy. | We report the case of a 58-year-old woman who presented with left hip pain and was diagnosed with femoroacetabular impingement. She underwent hip arthroscopy to repair a degenerative labral tear, as well as radiofrequency debridement and microfracture of the exposed chondral defect, and femoral osteoplasty. Two months ... | 25,218,006 | [
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Role of patient education in the perception and acceptance of home monitoring after recent implantation of cardioverter defibrillators: the EDUCAT study. | Much attention is being paid to the education of and provision of medical information to patients, to optimize their understanding and acceptance of their disease. To ascertain the impact of educating recent recipients of an implantable cardioverter defibrillator (ICD) on their perception and acceptance of a home monit... | 25,218,008 | [
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Microchip-based human serum atherogenic lipoprotein profile analysis. | Owing to the mounting evidence of serum lipid changes in atherosclerosis, there has been increasing interest in developing new methods for analyzing atherogenic lipoprotein profiles. The separation of lipoprotein and lipoprotein subclasses has been demonstrated using a microchip capillary electrophoresis (CE) system [C... | 25,218,022 | [
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In vivo detection of hyperoxia-induced pulmonary endothelial cell death using (99m)Tc-duramycin. | (99m)Tc-duramycin, DU, is a SPECT biomarker of tissue injury identifying cell death. The objective of this study is to investigate the potential of DU imaging to quantify capillary endothelial cell death in rat lung injury resulting from hyperoxia exposure as a model of acute lung injury. Rats were exposed to room air ... | 25,218,023 | [
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(18)F-fluoromethylcholine (FCho), (18)F-fluoroethyltyrosine (FET), and (18)F-fluorodeoxyglucose (FDG) for the discrimination between high-grade glioma and radiation necrosis in rats: a PET study. | Discrimination between (high-grade) brain tumor recurrence and radiation necrosis (RN) remains a diagnostic challenge because both entities have similar imaging characteristics on conventional magnetic resonance imaging (MRI). Metabolic imaging, such as positron emission tomography (PET) could overcome this diagnostic ... | 25,218,024 | [
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Simple and accurate quantitative analysis of 20 anti-tuberculosis drugs in human plasma using liquid chromatography-electrospray ionization-tandem mass spectrometry. | A simple and accurate liquid chromatography (LC)-tandem mass spectrometry (MS/MS) method for the quantitation of 20 anti-tuberculosis (anti-TB) drugs in human plasma, was developed as a tool for therapeutic drug monitoring. Two protein precipitation methods were adopted; one using methanol containing 0.13N HCl, for pre... | 25,218,029 | [
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Career interest, self-efficacy, and perception in undecided and nursing undergraduate students: a quantitative study. | Career choice variables of career interest, self-efficacy, and perception were chosen based upon Social Cognitive Career Theory concepts for study between nursing and undecided undergraduate student groups. Components of the Career Search Questionnaire and Perceptions of Professional Nursing instruments were combined a... | 25,218,036 | [
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Fluoxetine potentiation of methylphenidate-induced gene regulation in striatal output pathways: potential role for 5-HT1B receptor. | Drug combinations that include the psychostimulant methylphenidate plus a selective serotonin reuptake inhibitor (SSRI) such as fluoxetine are increasingly used in children and adolescents. For example, this combination is indicated in the treatment of attention-deficit/hyperactivity disorder and depression comorbidity... | 25,218,038 | [
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Mode of action of allatostatins in the regulation of juvenile hormone biosynthesis in the cockroach, Diploptera punctata. | The FGLamide allatostatins (FGL/ASTs) are a family of neuropeptides with pleiotropic functions, including the inhibition of juvenile hormone (JH) biosynthesis, vitellogenesis and muscle contraction. In the cockroach, Diploptera punctata, thirteen FGLa/ASTs and one allatostatin receptor (AstR) have been identified. Howe... | 25,218,044 | [
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A systematic review of genetic diversity of human rotavirus circulating in South Korea. | Rotavirus infections continue to be the leading cause of severe diarrhea in young Korean children. Rotavirus data acquired from uninterrupted surveillance studies between 1989 and 2009 in South Korea were analyzed to better understand the genetic diversity and evolution. The relationship between rotaviruses and the cur... | 25,218,045 | [
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Satisfaction with substance use treatment and 12-step groups predicts outcomes. | Satisfaction is a critical component of patient-centered care, yet little is known about the degree to which patient satisfaction is linked to subsequent outcomes, especially in substance use disorder (SUD) treatments and 12-step groups. The current study assessed the degree to which satisfaction with Department of Vet... | 25,218,068 | [
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Differential associations between components of anxiety sensitivity and smoking-related characteristics. | Anxiety sensitivity (AS)-the tendency to fear anxiety-related experiences-is a risk factor for anxiety disorders and may contribute to smoking motivation and maintenance. Few studies have examined the relations between conceptually distinct components of AS and smoking behavior. The purpose of the current study was to ... | 25,218,070 | [
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The role of mast cells in cutaneous wound healing in streptozotocin-induced diabetic mice. | Mast cells (MCs) reside in cutaneous tissue, and an increment of MCs is suggested to induce vascular regression in the process of wound healing. To clarify participation of MCs in diabetic cutaneous wound healing, we created an excisional wound on diabetic mice 4 weeks after streptozotocin injections and subsequently i... | 25,218,083 | [
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A kinetic model for curcumin production in Escherichia coli. | Curcumin is a natural compound obtained from turmeric, and is well known for its pharmacological effects. In this work, we design a heterologous pathway for industrial production of curcumin in Escherichia coli. A kinetic model of the pathway is then developed and connected to a kinetic model of the central carbon meta... | 25,218,090 | [
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Vanillic acid: a potential inhibitor of cardiac and aortic wall remodeling in l-NAME induced hypertension through upregulation of endothelial nitric oxide synthase. | The objective of the present study is to investigate the effects of vanillic acid on blood pressure, cardiac marker enzymes, left ventricular function and endothelial nitric oxide synthase (eNOS) expression in N(ω)-nitro-l-arginine methyl ester hydrochloride (l-NAME) induced hypertension in male albino Wistar rats. In ... | 25,218,092 | [
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Computed tomography-guided preoperative localization of abdominal wall endometrioma. | A multiparous obese patient with prior abdominal surgeries complained of cyclic abdominal pain located near the surgical scar. A 1 cm lesion was identified on imaging. Computed tomography-guided needle localization was performed immediately before surgery. This allowed for complete excision of the abdominal wall endome... | 25,218,124 | [
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Systems-based technologies in profiling the stem cell molecular framework for cardioregenerative medicine. | Over the last decade, advancements in stem cell biology have yielded a variety of sources for stem cell-based cardiovascular investigation. Stem cell behavior, whether to maintain its stable state of pluripotency or to prime toward the cardiovascular lineage is governed by a set of coordinated interactions between epig... | 25,218,144 | [
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Fronto-parietal network supports context-dependent speech comprehension. | Knowing the context of a discourse is an essential prerequisite for comprehension. Here we used functional magnetic resonance imaging (fMRI) to disclose brain networks supporting context-dependent speech comprehension. During fMRI, 20 participants listened to 1-min spoken narratives preceded by pictures that were eithe... | 25,218,167 | [
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Time course of cytokine upregulation in the lacrimal gland and presence of autoantibodies in a predisposed mouse model of Sjögren's Syndrome: the influence of sex hormones and genetic background. | Sjögren's Syndrome (SS) is a chronic, inflammatory autoimmune disease characterized by lacrimal gland lymphocytic infiltration and epithelial cell death, as well as by the presence of serum autoantibodies. Although the symptoms of this syndrome are well characterized, patients are not diagnosed until 5-10 years into di... | 25,218,176 | [
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Spectral fluctuation dividing for efficient wavenumber selection: application to estimation of water and drug content in granules using near infrared spectroscopy. | In process analytical technology (PAT) based on near infrared (NIR) spectroscopy, wavenumber selection is crucial to develop an accurate and robust calibration model. The present research proposes new efficient spectral dividing and wavenumber selection methods to significantly reduce the computational load required by... | 25,218,183 | [
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Brain parenchymal TNF-α and IL-1β induction in experimental pneumococcal meningitis. | Triggers of brain inflammation in pneumococcal meningitis are unknown. TNF-α and IL-1β were upregulated (real time PCR and in situ hybridization) in neurons and astrocytes time-dependently and maximally in the hippocampus during murine pneumococcal meningitis. Upregulation of TNF-α and IL-1β mRNA in the brain parenchym... | 25,218,213 | [
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Synthesis, characterization and anti-bacterial activities of pure and Co-doped BaSO4 nanoparticles via chemical precipitation route. | In the present study, we reported that the synthesis and characterization of pure and diverse mole Co-doped BaSO4 nanoparticles have been synthesized by chemical precipitation technique. X-ray diffraction analysis (XRD) brought out the information about the synthesized products is orthorhombic structure and highly crys... | 25,218,222 | [
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Green synthesis and applications of Au-Ag bimetallic nanoparticles. | This paper reports for the first time the synthesis of bimetallic nanoparticles at room temperature using the fruit juice of pomegranate. Simultaneous reduction of gold and silver ions in different molar ratios leads to the formation of alloy as well as core-shell nanostructures. The nanoparticles have been characteriz... | 25,218,228 | [
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Inactivation of the pore-forming toxin Sticholysin I by peroxynitrite: protection by cys groups incorporated in the toxin. | Sea anemones synthesize a variety of toxic peptides and proteins of biological interest. The Caribbean Sea anemone Stichodactyla helianthus, produces two pore-forming toxins, Sticholysin I (St I) and Stichloysin II (St II), with the ability to form oligomeric pores in cell and lipid bilayers characteristically lacking ... | 25,218,252 | [
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Investigation of the synergistic effects for p-nitrophenol mineralization by a combined process of ozonation and electrolysis using a boron-doped diamond anode. | Electrolysis and ozonation are two commonly used technologies for treating wastewaters contaminated with nitrophenol pollutants. However, they are often handicapped by their slow kinetics and low yields of total organic carbon (TOC) mineralization. To improve TOC mineralization efficiency, we combined electrolysis usin... | 25,218,262 | [
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[Down syndrome maternal serum screening: results' comments recommended by accredited biologists]. | Down syndrome maternal serum screening is largely used in France. The aim of this article is to specify and to explain the different comments applied on the reports in order to optimize the management of the patient. These comments represent the consensus of the study group of the biologist accredited for Down syndrome... | 25,218,268 | [
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CsIFIT1, an interferon-induced protein with tetratricopeptide repeat, inhibits viral infection in tongue sole (Cynoglossus semilaevis). | Interferon-induced protein with tetratricopeptide repeats (IFIT) is involved in antiviral immunity in mammalian cells. In fish, the function of this group of proteins is unknown. In this study, we report the identification of an IFIT homologue (named CsIFIT1) from tongue sole (Cynoglossus semilaevis) and examined its a... | 25,218,274 | [
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Restricted expression of karyopherin alpha mRNA in the sea urchin suggests a role in neurogenesis. | Karyopherin alpha (KAP-α) proteins are critical for the transport of many molecules into the nucleus. In this study, we identified three members of the KAP-α family in the sea urchin Lytechinus variegatus and described the developmental expression of these proteins. Although many importins are assumed to have ubiquitou... | 25,218,279 | [
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An Air-Well sparging minifermenter system for high-throughput protein production. | Over the last few years High-Throughput Protein Production (HTPP) has played a crucial role for functional proteomics. High-quality, high yield and fast recombinant protein production are critical for new HTPP technologies. Escherichia coli is usually the expression system of choice in protein production thanks to its ... | 25,218,288 | [
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Atorvastatin ameliorates arsenic-induced hypertension and enhancement of vascular redox signaling in rats. | Chronic arsenic exposure has been linked to elevated blood pressure and cardiovascular diseases, while statins reduce the incidence of cardiovascular disease predominantly by their low density lipoprotein-lowering effect. Besides, statins have other beneficial effects, including antioxidant and anti-inflammatory activi... | 25,218,292 | [
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Immunogenicity of bivalent HPV vaccine among partially vaccinated young adolescent girls in Uganda. | Investigations of vaccine efficacy and immunogenicity for adult females receiving fewer than three doses of human papillomavirus (HPV) vaccine have suggested protection against infection and precancerous lesions. We investigated the immunogenicity of bivalent HPV vaccines among adolescent girls from Uganda who received... | 25,218,297 | [
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Acute toxicity and genotoxicity study of fermented traditional herb formula Guibi-tang. | Guibi-tang (Guipi-tang in Chinese and Kihi-to in Japanese) is a multi-herb traditional medicine commonly prescribed to treat psychoneurosis in East Asia. Although this medicine has been widely used, there is little available information on the safety and toxicity of Guibi-tang, especially on the fermented one. Guibi-ta... | 25,218,323 | [
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The influence of mtDNA deletion on lung cancer cells under the conditions of hypoxia and irradiation. | This study was to evaluate the influence of mtDNA deletion on the lung cancer cells under the conditions of hypoxia or irradiation. The treatment conditions of lung cancer cell lines with (A549) and without mtDNA (ρ0A549: obtained by inducing from A549) included 2 h of hypoxia and 4 Gy irradiation (group 1: without tre... | 25,218,334 | [
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B cell CLL/lymphoma 6 member B inhibits hepatocellular carcinoma metastases in vitro and in mice. | B cell CLL/lymphoma 6 member B (BCL6B) is a novel tumor suppressor silenced in human cancer. In this study, we investigated the functional role and underlying mechanisms of BCL6B in hepatocellular carcinoma (HCC). BCL6B was expressed in normal HCC tissues, but its expression was suppressed in 6 out of 9 HCC cell lines.... | 25,218,345 | [
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Diagnosis and management of ureteral fibroepithelial polyps in children: a new treatment algorithm. | Fibroepithelial polyps are benign mesenchymal tumors arising from the urinary tract. With the advent of endoscopy in the pediatric population, more reports of endoscopic diagnosis and treatment have appeared. The present study reports experience with the diagnosis and treatment of fibroepithelial polyps of the upper ur... | 25,218,353 | [
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Personality characteristics in surgery seeking and non-surgery seeking obese individuals compared to non-obese controls. | It is currently unknown what makes some obese individuals opt for bariatric surgery whereas others choose not to. The aim of this study was to examine whether personality characteristics differed between obese individuals signed up for Roux-en-Y gastric bypass (RYGB) (N=30) and obese individuals not seeking RYGB (N=30)... | 25,218,357 | [
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Risk factors for Richter syndrome in chronic lymphocytic leukemia. | Richter syndrome (RS) is defined as the transformation of chronic lymphocytic leukemia (CLL) to a more aggressive B-cell lymphoma, most commonly diffuse large B-cell lymphoma. Approximately 5-10% of CLL patients develop this complication during long-term follow-up. Traditional risk factors for future RS include clinica... | 25,218,362 | [
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Sensitive and specific in situ hybridization for early drug discovery. | High-throughput analyses of gene expression such as microarrays and RNA-sequencing are widely used in early drug discovery to identify disease-associated genes. To further characterize the expression of selected genes, in situ hybridization (ISH) using RNA probes (riboprobes) is a powerful tool to localize mRNA express... | 25,218,381 | [
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Spodoptera frugiperda (J.E. Smith) with field-evolved resistance to Bt maize are susceptible to Bt pesticides. | Field-evolved resistance to maize event TC1507 expressing the Cry1Fa toxin from Bacillus thuringiensis (Bt) was detected in populations of Spodoptera frugiperda from Puerto Rico. We tested for cross-resistance to purified Cry1A toxins and commercial Bt pesticides in susceptible (Benzon) and TC1507-resistant (456) strai... | 25,218,399 | [
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Immunogenicity and protective efficacy of a major White Spot Syndrome Virus (WSSV) envelope protein VP24 expressed in Escherichia coli against WSSV. | The study reports cloning, expression and characterization of immunogenic activity of VP24, a major envelope protein of White Spot Syndrome Virus (WSSV). His-tagged VP24 was expressed as truncated protein and purified from inclusion bodies by metal affinity chromatography under denaturing conditions. The ability to con... | 25,218,401 | [
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The effect of tracheal occlusion on respiratory load compensation: changes in neurons containing inhibitory neurotransmitter in the nucleus of the solitary tract in conscious rats. | Respiratory load compensation volume-time (Vt-T) relationships have been extensively studied in anesthetized animals. There are only a few studies in conscious animals although consciousness and behavior play a critical role in modulation of breathing. The aims of the study were to determine the effect of intermittent ... | 25,218,413 | [
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Uncovering global SUMOylation signaling networks in a site-specific manner. | SUMOylation is a reversible post-translational modification essential for genome stability. Using high-resolution MS, we have studied global SUMOylation in human cells in a site-specific manner, identifying a total of >4,300 SUMOylation sites in >1,600 proteins. To our knowledge, this is the first time that >1... | 25,218,447 | [
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Transfection of wtp53 and Rb94 genes into retinoblastomas of nude mice by ultrasound-targeted microbubble destruction. | Using ultrasound-targeted microbubble destruction (UTMD), we transfected both wild-type p53 (wtp53) and Rb94 genes into retinoblastomas (RBs) of nude mice to investigate the inhibitory role of these two genes in RB development. The 40 tumor-bearing mice, which had been established by sub-retinal injection of an HXO-Rb4... | 25,218,456 | [
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Occupational biomechanical exposure predicts low back pain in older age among men in the Gazel Cohort. | Occupational biomechanical exposures are considered as risk factors for low back pain in the working population. It has also been suggested that their effects persist after retirement. Our objectives were to assess the role of past biomechanical occupational exposure on low back pain in early old age among male partici... | 25,218,459 | [
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Comparative analysis of virulence of a novel, avian-origin H3N2 canine influenza virus in various host species. | A novel avian-origin H3N2 canine influenza A virus (CIV) that showed high sequence similarities in hemagglutinin and neuraminidase genes with those of non-pathogenic avian influenza viruses was isolated in our routine surveillance program in South Korea. We previously reported that the pathogenicity of this strain coul... | 25,218,482 | [
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Prion-like mechanisms in the pathogenesis of tauopathies and synucleinopathies. | Neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, are characterized by the abnormal aggregation of a small number of intracellular proteins, with tau and α-synuclein being the most commonly affected. Until recently, the events leading to aggregate formation were believed to be entirely ... | 25,218,483 | [
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Evidence for the mutual effects of dimethylsulfoniopropionate and nitric oxide during the growth of marine microalgae. | Dimethylsulfoniopropionate (DMSP) and nitric oxide (NO) in marine microalgae are considered as two important compounds involved in a variety of physiological functions. We examined the NO responses and the growth of Isochrysis galbana Parke and Gymnodinium sp. when supplemented with different concentrations of DMSP sol... | 25,218,514 | [
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The second dorsal metacarpal artery chain-link flap: an anatomical study and a case report. | The purpose of this study was to discuss the distribution characteristics and the anatomical angioarchitecture of cutaneous branches arising from the second dorsal metacarpal artery for the repair of small tissue defects in the hand or fingers using the second dorsal metacarpal artery chain-link flap. Fifteen fresh hum... | 25,218,515 | [
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New engineering treatment of bovine pericardium confers outstanding resistance to calcification in mitral and pulmonary implantations in a juvenile sheep model. | To conduct a test of noninferiority for CardioCel (Admedus, Brisbane, Australia), a chemically engineered bovine pericardium over autologous pericardium treated intraoperatively with glutaraldehyde in a chronic juvenile sheep model of pulmonary valve (PV) and mitral valve (MV) reconstruction. We replaced the posterior ... | 25,218,528 | [
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Volatile anesthetics in preventing acute kidney injury after cardiac surgery: a systematic review and meta-analysis. | Acute kidney injury is a common clinical complication of cardiac surgery. Volatile anesthetics have been shown to protect against it in animal experiments. Clinically, however, the effect of volatile anesthetics has been unclear. We conducted a systematic review and meta-analysis of randomized, controlled trials to exp... | 25,218,542 | [
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Neural plasticity underlying visual perceptual learning in aging. | Healthy aging is associated with a decline in basic perceptual abilities, as well as higher-level cognitive functions such as working memory. In a recent perceptual training study using moving sweeps of Gabor stimuli, Berry et al. (2010) observed that older adults significantly improved discrimination abilities on the ... | 25,218,557 | [
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Apolipoprotein E ε4 allele modulates the immediate impact of acute exercise on prefrontal function. | The difference between Apolipoprotein E ε4 carriers and non-carriers in response to single exercise sessions was tested. Stroop and Posner tasks were administered to young untrained women immediately after walking sessions or moderately heavy exercise. Exercise had a significantly more profound impact on the Stroop eff... | 25,218,559 | [
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Achievements and perspectives in prostate cancer phase 3 trials from genitourinary research groups in Europe: introducing the Prostate Cancer Consortium in Europe. | Phase 3 trials have made major contributions to advances in prostate cancer (PCa). However, funding limitations and excess bureaucracy are now making it difficult to conduct trials. To describe the collaborative groups in Europe and their academic phase 3 PCa trials. Leaders of collaborative groups from Scandinavia, th... | 25,218,582 | [
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MiR-152 functions as a tumor suppressor in glioblastoma stem cells by targeting Krüppel-like factor 4. | Glioblastoma (GBM) is the most common central nervous system tumor and the molecular mechanism driving its development is still largely unknown, limiting the treatment of this disease. In the present study, we explored the potential role of miR-152 in glioblastoma stem cells (GSCs) as well as the possible molecular mec... | 25,218,589 | [
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Atovaquone and quinine anti-malarials inhibit ATP binding cassette transporter activity. | Therapeutic blood plasma concentrations of anti-malarial drugs are essential for successful treatment. Pharmacokinetics of pharmaceutical compounds are dependent of adsorption, distribution, metabolism, and excretion. ATP binding cassette (ABC) transport proteins are particularly involved in drug deposition, as they ar... | 25,218,605 | [
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Upper and lower urinary tract infections can be detected early but not be discriminated by urinary NGAL in adults. | We investigated whether the recently established biomarkers of acute kidney injury, neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1), may help to diagnose acute urinary tract infections (UTI) in adults and are able to distinguish between upper or lower localization. NGAL levels wer... | 25,218,613 | [
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Emergent double valve replacement in Austrian syndrome. | Bi-valvular pneumococcal endocarditis in Austrian syndrome, which includes a triad of pneumococcal endocarditis, pneumonia, and meningitis, is a rare but life-threatening disease. We present a case of a woman found to have Austrian syndrome who presented to the emergency department (ED) with dehydration and radiographi... | 25,218,621 | [
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Spotted lipid sign floating on the blood to differentiate obscured open fractures from simple wound lacerations. | Open fractures are not so obvious sometimes, and in the case of multiorgan injuries, they may be misdiagnosed in emergency department. Here, we report a 48-year old man with motor vehicle crash injury. There were ominous facial, vertebral, thoracic, and abdominal injuries as well as distal femoral shaft fracture and mu... | 25,218,624 | [
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A simulation study on the significant nanomechanical heterogeneous properties of collagen. | Nanomechanics of individual collagen fibrils govern the mechanical behavior of the majority of connective tissues, yet the current models lack significant details. Majority of the current models assume a rod-shape molecule with homogenous mechanical properties. Recent X-ray crystallography revealed significantly differ... | 25,218,640 | [
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Biaxial mechanical properties of swine uterosacral and cardinal ligaments. | Mechanical alterations to pelvic floor ligaments may contribute to the development and progression of pelvic floor disorders. In this study, the first biaxial elastic and viscoelastic properties were determined for uterosacral ligament (USL) and cardinal ligament (CL) complexes harvested from adult female swine. Biaxia... | 25,218,641 | [
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A new group of anti-lipopolysaccharide factors from Marsupenaeus japonicus functions in antibacterial response. | Anti-lipopolysaccharide factors (ALFs) are a group of critical effector molecules with a broad spectrum of antimicrobial activities in crustaceans. Four groups of ALFs (A, B, C, and D) have been identified in peneaid shrimp. In the study, we identified a new group of ALFs (designated as MjALF-E) from Marsupenaeus japon... | 25,218,642 | [
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Hypermobility and joint hypermobility syndrome in Brazilian students and teachers of ballet dance. | The current literature has been discussing the risks and benefits of joint hypermobility (JHM) for careers in ballet This study aimed to evaluate the prevalence of JHM and joint hypermobility syndrome (JHS) in a group of ballet teachers and students, looking both at aspects related to the flexibility required to dance,... | 25,218,649 | [
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Stress distributions in human teeth modeled with a natural graded material distribution. | This study aimed to investigate how the structural stress distribution in human teeth could be affected by the presence of a graded material distribution often found in nature using the finite element (FE) method. Hydroxyapatite (HA) tablets with different densities were scanned using a Micro-CT scanner to obtain a rel... | 25,218,658 | [
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The long-term effects of prenatal nicotine exposure on verbal working memory: an fMRI study of young adults. | Using functional magnetic resonance imaging (fMRI), the long-term effects of prenatal nicotine exposure on verbal working memory were investigated in young adults. Participants were members of the Ottawa Prenatal Prospective Study, a longitudinal study that collected a unique body of information on participants from in... | 25,218,661 | [
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Plasma microRNA-186 and proteinuria in focal segmental glomerulosclerosis. | MicroRNAs (miRNAs) are stable in circulation, and their unique expression profiles can serve as fingerprints for various diseases. This study explored whether plasma miRNAs could be used as biomarkers to evaluate disease activity in patients with focal segmental glomerulosclerosis (FSGS). Retrospective and prospective ... | 25,218,681 | [
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Looking at protists as a source of pathogenic viruses. | In the environment, protozoa are predators of bacteria and feed on them. The possibility that some protozoa could be a source of human pathogens is consistent with the discovery that free-living amoebae were the reservoir of Legionella pneumophila, the agent of Legionnaires' disease. Later, while searching for Legionel... | 25,218,687 | [
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Imaging strategies for assessing cartilage composition in osteoarthritis. | Efforts to reduce the ever-increasing rates of osteoarthritis (OA) in the developed world require the ability to non-invasively detect the degradation of joint tissues before advanced damage has occurred. This is particularly relevant for damage to articular cartilage because this soft tissue lacks the capacity to repa... | 25,218,737 | [
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Substrate-dependent switching of the allosteric binding mechanism of a dimeric enzyme. | Enzyme activity is commonly controlled by allostery, where ligand binding at one site alters the activities of distant sites. Classical explanations for multisubunit proteins involve conformational transitions that are fundamentally deterministic. For example, in the Monod-Wyman-Changeaux (MWC) paradigm, conformational... | 25,218,742 | [
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Pathogen-specific incidence rate of clinical mastitis in Flemish dairy herds, severity, and association with herd hygiene. | A one-year survey on clinical mastitis was conducted on 50 randomly selected commercial Flemish dairy herds to estimate the pathogen-specific incidence rate of clinical mastitis (IRCM). The severity of the cases and the potential associations with herd hygiene were studied. Participating producers sampled 845 cases and... | 25,218,745 | [
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Prevalence and characterization of Salmonella enterica in dried milk-related infant foods in Shaanxi, China. | The aim of this study was to investigate the existence and characteristics of Salmonella enterica in dried milk-related infant foods. Twenty-four (3.4%) of 705 samples, including 5 (2.0%) of 246 powdered infant formula, 18 (4.0%) of 445 infant rice cereal, and 1 (7.1%) of 14 other infant foods, were positive for Salmon... | 25,218,754 | [
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Differentiation of BIRADS-4 small breast lesions via Multimodal Ultrasound Tomography. | To demonstrate the use of a new 3D diagnostic imaging technology, termed Multimodal Ultrasonic Tomography (MUT), for the detection of solid breast lesions < 15 mm in maximum dimension. 3D MUT imaging was performed on 71 volunteers presenting BIRADS-4 nodules, asymmetrical densities, and architectural distortions in ... | 25,218,763 | [
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Detailed analysis of the density change on chest CT of COPD using non-rigid registration of inspiration/expiration CT scans. | One objective was to evaluate the air trapping index (ATI), measured by inspiration/expiration CT, in COPD patients and nonsmokers. Another objective was to assess the association between the pulmonary function test (PFT) and CT parameters such as ATI or other indices, separately in the whole lung, in emphysema, and in... | 25,218,764 | [
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0.448954,
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-0.1303272,
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0.3720765,
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Sonochemical synthesis of iron oxide nanoparticles loaded with folate and cisplatin: effect of ultrasonic frequency. | Simple preparative methods were used to sonosynthesize different magnetic iron oxide nanoparticles (FeNPs) via co-precipitation of aqueous solutions of ferrous salts in a basic aqueous solution of ethylene glycol (EG). Sonosynthesis was achieved using different frequencies of ultrasound: 581, 861, and 1141 kHz under th... | 25,218,767 | [
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... |
Characterization of stable and transient cavitation bubbles in a milliflow reactor using a multibubble sonoluminescence quenching technique. | The bubble type, generated by an ultrasonic field, was studied in a batch and flow reactor using a multibubble sonoluminescence (MBSL) quenching technique with propanol and acetone. The influence of frequency and transducer configuration was evaluated using the same piezoelectric element in both setups. Results show th... | 25,218,768 | [
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... |
Obtaining lignin nanoparticles by sonication. | Lignin, the main natural aromatic polymer was always aroused researchers interest. Currently around 90% of this biomaterial is burned for energy. It has a very complex and complicated structure which depends on the separation method and plant species, what determine difficulties to use as a raw material widely. This re... | 25,218,770 | [
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Synthesis of novel palladium(0) nanocatalysts by microorganisms from heavy-metal-influenced high-alpine sites for dehalogenation of polychlorinated dioxins. | In a search for new aqueous-phase systems for catalyzing reactions of environmental and industrial importance, we prepared novel biogenerated palladium (Pd) nanocatalysts using a "green" approach based on microorganisms isolated from high-alpine sites naturally impacted by heavy metals. Bacteria and fungi were enriched... | 25,218,779 | [
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0.1156618,
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0... |
Safety profile of boceprevir and telaprevir in chronic hepatitis C: real world experience from HCV-TARGET. | The safety profiles of boceprevir and telaprevir in the treatment of chronic hepatitis C, administered in academic and community centres across the United States, were evaluated. In 90 medical centres, patients with chronic HCV received pegylated interferon, ribavirin, and either telaprevir or boceprevir per local stan... | 25,218,788 | [
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0.1791478,
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0.1796269,
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... |
JBP1-seq: a fast and efficient method for genome-wide profiling of 5hmC. | We developed a novel approach, J-binding protein 1 sequencing (JBP1-seq), that combines the benefits of an improved recombinant JBP1 protein, Nextera-based library construction, and next-generation sequencing (NGS) for genome-wide profiling of 5-hydroxymethylcytosine (5hmC). Compared with the original JBP1, this new re... | 25,218,799 | [
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0.03060054,
0.06995123,
0.2768854,
-0.004029003,
... |
Cephalometric norms for the upper airway of 12-year-old Chinese children. | To establish cephalometric norms for the upper airway of 12-year-old Chinese children, and to assess these norms with regard to gender, age, ethnicity and other craniofacial structures. Lateral cephalograms were obtained from a random sample of 425 12-year-old Chinese children (224 boys and 201 girls) to establish the ... | 25,218,804 | [
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0.02969839,
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0.2352844,
-0.2236129... |
Digital quantitation of HCC-associated stem cell markers and protein quality control factors using tissue arrays of human liver sections. | The most common type of liver cancer, hepatocellular carcinoma (HCC), affects over 500,000 people in the world. In the present study, liver tumor resections were used to prepare tissue arrays to examine the intensity of fluorescence of IHC stained stem cell markers in liver tissue from malignant HCC tumors and accompan... | 25,218,810 | [
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0.1761772,
0.1871041,
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... |
Serum albumin-adjusted glycated albumin is an adequate indicator of glycemic control in patients with Cushing's syndrome. | We recently reported that glycated albumin (GA) in patients with Cushing's syndrome is low. In the present study, we examined whether serum albumin (SA)-adjusted GA (SAaGA) is an adequate indicator of glycemic control in patients with Cushing's syndrome. We studied 26 patients with Cushing's syndrome (13 patients witho... | 25,218,816 | [
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0.147749,
0.04981632,
0.109592,
-0.4520822,
-0.164062,
-0.1842538,
-0.095... |
Second-Guessing Scientists and Engineers: Post Hoc Criticism and the Reform of Practice in Green Chemistry and Engineering. | The article examines and extends work bringing together engineering ethics and Science and Technology Studies, which had built upon Diane Vaughan's analysis of the Challenger shuttle accident as a test case. Reconsidering the use of her term "normalization of deviance," the article argues for a middle path between mora... | 25,218,835 | [
-0.2801943,
0.06807068,
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0.2293375,
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-0.05897392,
-0.03681885,
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0.09404028,
-0.2... |
Analysis of finite element method on mechanical properties of wheat kernel. | The scattered cases of wheat kernels were examined for ensuring the direction of wheat kernels. Above 50% kernels of wheat were back up and about 43% were sides up. Finite element method was performed to simulate stress distributions inside a wheat kernel during storage. The distributions of fixture, force, tangential,... | 25,218,840 | [
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0.4362168,
0.374904,
-0.08482505,
0... |
Cellular density in the cerebellar molecular layer in essential tremor, spinocerebellar ataxia, and controls. | It would be useful to identify additional postmortem markers of Purkinje cell loss in essential tremor (ET). In hereditary cerebellar ataxia, Purkinje cell loss has been reported to result in a secondary increase in the density of the remaining cell populations in the cerebellar molecular layer. However, this phenomeno... | 25,218,844 | [
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0.413405,
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0.1422174,
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Select steroid hormone glucuronide metabolites can cause toll-like receptor 4 activation and enhanced pain. | We have recently shown that several classes of glucuronide metabolites, including the morphine metabolite morphine-3-glucuronide and the ethanol metabolite ethyl glucuronide, cause toll like receptor 4 (TLR4)-dependent signaling in vitro and enhanced pain in vivo. Steroid hormones, including estrogens and corticosteron... | 25,218,902 | [
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0.09702667,
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0.08156729,
0.05149858,
... |
Familial nonmedullary thyroid cancer: screening, clinical, molecular and genetic findings. | Thyroid cancer, the commonest of endocrine malignancies, continues increasing in incidence being the 5th more prevalent cancer among women in the United States in 2012. Familial thyroid cancer has become a well-recognized, unique, clinical entity in patients with thyroid cancer originating from follicular cells, that i... | 25,218,916 | [
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0.1095334,
0.2342278,
-0.3720042,
... |
Transmembrane signaling in Saccharomyces cerevisiae as a model for signaling in metazoans: state of the art after 25 years. | In the very first article that appeared in Cellular Signalling, published in its inaugural issue in October 1989, we reviewed signal transduction pathways in Saccharomyces cerevisiae. Although this yeast was already a powerful model organism for the study of cellular processes, it was not yet a valuable instrument for ... | 25,218,923 | [
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0.3956086,
0.1886597,
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Targeted delivery of anticancer drugs by aptamer AS1411 mediated Pluronic F127/cyclodextrin-linked polymer composite micelles. | Aptamers are single-stranded RNA or DNA ligands that can specifically bind to various molecular targets with high affinity. Owing to this unique character, they have become increasingly attractive in the field of drug delivery. In this study, we developed a multifunctional composite micelle (CM) with surface modificati... | 25,218,928 | [
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0.3361487,
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Neurocomputational approaches to modelling multisensory integration in the brain: a review. | The Brain's ability to integrate information from different modalities (multisensory integration) is fundamental for accurate sensory experience and efficient interaction with the environment: it enhances detection of external stimuli, disambiguates conflict situations, speeds up responsiveness, facilitates processes o... | 25,218,929 | [
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0.2302033,
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0.1008198,
-0.1092468,... |
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