title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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[Effect of Pi transportation, dampness resolving and phlegm expelling herbs on the obesity degree, fat hormones, and leptin resistance in diet-induced obesity rats]. | To observe the effect of Pi transportation, dampness resolving and phlegm expelling herbs (PTDRPEH) on the obesity degree, fat hormones, and leptin resistance in diet-induced obesity (DIO) rats. Among the 120 Wister rats, 10 were recruited as the blank control group (fed with basal forage), and the remaining 110 were a... | 25,223,188 | [
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[Benefit of ocular draping on bacterial contamination after intravitreal injection using a plate-type eyelid speculum]. | To evaluate the effect of ocular draping on rates of bacterial contamination of the ocular surface immediately after intravitreal injection using a plate-type eyelid speculum. Twelve institutions participated in this prospective randomized study. Patients from each institution undergoing intravitreal injections were ra... | 25,223,208 | [
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[Investigation of clinical characteristics and surgical treatment for conjunctival epithelial inclusion cyst]. | To investigate the clinical characteristics and surgical treatment in eyes with conjunctival epithelial inclusion cysts (CEIC). This study involved the retrospective, medical-record-based investigation of 37 eyes of 34 patients diagnosed with CEIC by slit-lamp biomicroscopy and anterior segment optical coherence tomogr... | 25,223,210 | [
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[Effects of physics on development of optometry in the United States from the late 19th to the mid 20th century]. | In this paper, it was studied how physics affected development of optometry in the United States, from aspects of formation and academization of optometry. It was also revealed that history of optometry was analogous to history of engineering. Optics in the 19th century was divided into electromagnetic study of light a... | 25,223,224 | [
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Atomically resolved imaging of highly ordered alternating fluorinated graphene. | One of the most desirable goals of graphene research is to produce ordered two-dimensional (2D) chemical derivatives of suitable quality for monolayer device fabrication. Here we reveal, by focal series exit wave reconstruction (EWR), that C2F chair is a stable graphene derivative and demonstrates pristine long-range o... | 25,223,226 | [
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Asymmetric reduction of α-amino ketones with a KBH4 solution catalyzed by chiral Lewis acids. | An efficient enantioselective reduction of α-amino ketones with potassium borohydride solution catalyzed by chiral N,N'-dioxide-metal complex catalysts was accomplished under mild reaction conditions for the first time. It provided a simple, convenient, and practical approaches for obtaining synthetically important chi... | 25,223,259 | [
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Identification of oxidative stress and responsive genes of HepG2 cells exposed to quinocetone, and compared with its metabolites. | Quinocetone, a new quinoxaline 1,4-dioxide derivative used in food-producing animals in China, exerts genotoxic effects on HepG2 cells. It triggers significant cytotoxicity and genotoxicity in vitro, but the detailed mechanism by which quinocetone induces adverse biological effects is not yet known. We analyzed the mec... | 25,223,261 | [
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Vaccination recommendations for patients with neuromuscular disease. | Neuromuscular diseases (NMDs) encompass a broad spectrum of conditions. Because infections may be relevant to the final prognosis of most NMDs, vaccination appears to be the simplest and most effective solution for protecting NMD patients from vaccine-preventable infections. However, very few studies have evaluated the... | 25,223,270 | [
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Using aqueous ammonia in hydroaminomethylation reactions: ruthenium-catalyzed synthesis of tertiary amines. | The direct synthesis of tertiary amines from ammonia and olefins is presented. Using a combination of Ru3 (CO)12 and 2-phosphino-substituted imidazole ligand as catalyst system allows for hydroaminomethylation reactions of bulk aliphatic and functionalized olefins. Tertiary amines are obtained in an atom-efficient domi... | 25,223,274 | [
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Cholesterol in brain disease: sometimes determinant and frequently implicated. | Cholesterol is essential for neuronal physiology, both during development and in the adult life: as a major component of cell membranes and precursor of steroid hormones, it contributes to the regulation of ion permeability, cell shape, cell-cell interaction, and transmembrane signaling. Consistently, hereditary diseas... | 25,223,281 | [
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Impact of VANA academic-practice partnership participation on educational mobility decisions and teaching aspirations of nurses. | This study reports findings assessing the influence of the Department of Veterans Affairs Nursing Academy (VANA) academic-practice partnership program on nurse decision making regarding educational mobility and teaching aspirations. We conducted national surveys with nursing faculty from VANA partnership sites in 2011 ... | 25,223,286 | [
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From suicide survivor to peer counselor: breaking the silence of suicide bereavement. | This study sought to explore the phenomenon of peer counseling in suicide bereavement by addressing the question, what are the lived experiences of suicide survivors who become peer counselors? Participants were 15 individuals bereaved through suicide who had been volunteering with others bereaved in the same manner. T... | 25,223,311 | [
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Function of global regulator CodY in Bacillus thuringiensis BMB171 by comparative proteomic analysis. | CodY is a highly conserved protein in low G+C gram-positive bacteria that regulates genes involved in sporulation and stationary-phase adaptation. Bacillus thuringiensis is a grampositive bacterium that forms spores and parasporal crystals during the stationary phase. To our knowledge, the regulatory mechanism of CodY ... | 25,223,328 | [
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Genetic and physiological responses of three freshwater diatoms to realistic diuron exposures. | This study examined the effects of diuron on strains of three major freshwater diatom species, Eolimna minima, Nitzschia palea and Planothidium lanceolatum. These species are frequently recorded in the Morcille River, where diuron runs off during phytosanitary treatments of the vineyards around. Here, there were three ... | 25,223,354 | [
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"Ilizarov" external fixation: what the radiologist needs to know. | Circular external fixation, including the Ilizarov method, is a complex and often long-term treatment used for various orthopedic conditions. Due to the complexity of the hardware, frequent postoperative complications, and the potential for significant radiographic changes between visits, it is important for the radiol... | 25,223,361 | [
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Effect of folic acid on bone metabolism: a randomized double blind clinical trial in postmenopausal osteoporotic women. | In spite of several studies, the impact of homocysteine level and folic acid supplementation on bone metabolism is yet to be recognized. In this registered clinical trial (IRCT2014042217385N1), we aimed to find out the power of 6-month folic acid supplementation on homocysteine level and bone metabolism. Forty postmeno... | 25,223,378 | [
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Organic-inorganic azafullerene-gold C(59)N-Au nanohybrid: synthesis, characterization, and properties. | Azafullerene (C59 N) was functionalized using a Mannich-type reaction and then subsequently condensed with lipoic acid to yield dithiolane-modified C59 N. In the following step, the extended dithiolane moiety from the C59 N core was utilized to decorate the azafullerene sphere with gold nanoparticles (Au NPs). The latt... | 25,223,388 | [
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Two new diterpenoids from Leonotis leonurus R. Br. | Two new diterpenoids, 14α-hydroxy-9α,13α-epoxylabd-5(6)-en-7-on-16,15-olide (1) and 13ξ-hydroxylabd-5(6),8(9)-dien-7-on-16,15-olide (2) along with six known diterpenoids were isolated from the aerial parts of Leonotis leonurus R. Br. These structures were determined on the basis of spectroscopic analyses. Some of the i... | 25,223,430 | [
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The effect of local policy actions on mortality among homeless people: a before-after study. | Homeless people have a 3-5-fold increased risk of mortality compared with general populations. After 2005, policy actions being implemented in Rotterdam, the Netherlands, have improved the living conditions of this group. This study examines the effect of policies aimed at improving living conditions on mortality risks... | 25,223,433 | [
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Simultaneous variable selection for joint models of longitudinal and survival outcomes. | Joint models of longitudinal and survival outcomes have been used with increasing frequency in clinical investigations. Correct specification of fixed and random effects is essential for practical data analysis. Simultaneous selection of variables in both longitudinal and survival components functions as a necessary sa... | 25,223,432 | [
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Real time ligand-induced motion mappings of AChBP and nAChR using X-ray single molecule tracking. | We observed the dynamic three-dimensional (3D) single molecule behaviour of acetylcholine-binding protein (AChBP) and nicotinic acetylcholine receptor (nAChR) using a single molecule tracking technique, diffracted X-ray tracking (DXT) with atomic scale and 100 μs time resolution. We found that the combined tilting and ... | 25,223,459 | [
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Efficacy and safety of the FOLFOX4 regimen versus doxorubicin in Chinese patients with advanced hepatocellular carcinoma: a subgroup analysis of the EACH study. | The EACH study assessed the efficacy of oxaliplatin, 5-fluorouracil, and leucovorin (the FOLFOX4 regimen) compared with doxorubicin alone in terms of overall survival (OS), progression-free survival (PFS), and safety in patients with advanced hepatocellular carcinoma (HCC). We present the results of this study in Chine... | 25,223,462 | [
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TPGS-g-PLGA/Pluronic F68 mixed micelles for tanshinone IIA delivery in cancer therapy. | Tanshinone IIA (TAN) has few clinical applications for anti-cancer therapy mainly due to its high lipophicity, low cellular uptake, and poor bioavailability. To improve the anti-cancer effect and bioavailability of TAN, we developed a mixed micelle system constituted with D-α-tocopheryl polyethylene glycol succinate-gr... | 25,223,472 | [
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Dance for people with Parkinson disease: what is the evidence telling us? | (1) To appraise and synthesize the literature on dance interventions for individuals with Parkinson disease (PD); (2) to provide information regarding the frequency, intensity, duration, and type of dance used in these programs; and (3) to inform the development of future studies evaluating dance interventions in this ... | 25,223,491 | [
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Development and characterization of co-loaded curcumin/triazole-halloysite systems and evaluation of their potential anticancer activity. | Positively charged halloysite nanotubes functionalized with triazolium salts (f-HNT) were employed as a carrier for curcumin molecules delivery. The synthesis of these f-HNT new materials is described. Their interaction with curcumin was evaluated by means dynamic light scattering (DLS) and UV-vis spectroscopy in compa... | 25,223,492 | [
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P3HT-based nanoarchitectural Fano solar cells. | The finite difference time domain simulation shows the existence of an asymmetric quadrupole of Fano resonance on the surface of a gold-silica core-shell (Au@silica) nanoparticle (NP) as being incorporated into the metal oxide nanoarchitecture/P3HT hybrid. Compared to the metal oxide nanoarchitecture/P3HT hybrid solar ... | 25,223,500 | [
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Silicon particles as trojan horses for potential cancer therapy. | Porous silicon particles (PSiPs) have been used extensively as drug delivery systems, loaded with chemical species for disease treatment. It is well known from silicon producers that silicon is characterized by a low reduction potential, which in the case of PSiPs promotes explosive oxidation reactions with energy yiel... | 25,223,512 | [
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High-speed separation and detection of amino acids in laver using a short capillary electrophoresis system. | A high-speed separation method of capillary MEKC with LIF detection had been developed for separation and determination of amino acids in laver. The CE system comprised a manual slotted-vial array (SVA) for sample introduction that could improve the separation efficiency by reducing injection volume. Using a capillary ... | 25,223,519 | [
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Inter- and intra-individual comparative study of two gadolinium-based agents: A pilot study. | The aim of the study was to evaluate the acute adverse events rate and enhancement properties of gadoterate meglumine (Dotarem(®)) and gadobenate dimeglumine (MultiHance(®)) in a small-scale controlled double-blinded study, using inter- and intra-individual comparisons. Forty-one randomly selected patients were scanned... | 25,223,524 | [
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Case-base methods for studying vaccination safety. | Pooling of controls under nested-case control settings can produce substantial efficiency gains compared to standard time-matched analysis using the Mantel-Haenszel method or conditional logistic regression. In the context of possible adverse effects of early childhood vaccinations, we propose pooling of the informatio... | 25,223,544 | [
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An FDA overview of rodent carcinogenicity studies of angiotensin II AT-1 receptor blockers: pulmonary adenomas and carcinomas. | Sipahi et al. (2010) performed a meta-analysis of 5 clinical trials (n=68,402) of 3 Angiotensin II (AngII) receptor subtype AT-1 blockers (ARBs) in cardiovascular disease. It revealed excess new lung cancer diagnoses in the cohorts treated with an ARB and background therapy (0.9% vs. 0.7% in non-ARB control; RR: 1.25; ... | 25,223,563 | [
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RhoGTPases, actomyosin signaling and regulation of the epithelial Apical Junctional Complex. | Epithelial cells form regulated and selective barriers between distinct tissue compartments. The Apical Junctional Complex (AJC) consisting of the tight junction (TJ) and adherens junction (AJ) control epithelial homeostasis, paracellular permeability and barrier properties. The AJC is composed of mutliprotein complexe... | 25,223,584 | [
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Investigating inhibitory control in children with epilepsy: an fMRI study. | Deficits in executive function are noted increasingly in children with epilepsy and have been associated with poor academic and psychosocial outcomes. Impaired inhibitory control contributes to executive dysfunction in children with epilepsy; however, its neuroanatomic basis has not yet been investigated. We used funct... | 25,223,606 | [
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Intraoperative fine-needle aspiration biopsy (FNA) for lung cancer: diagnostic value and risk of pleural dissemination. | Intraoperative fine-needle aspiration biopsy (FNA) is one of the most important diagnostic tools for undiagnosed lung nodules suspected of being lung cancer; however, the sensitivity and safety of FNA, including the risk of intrapleural dissemination of cancer cells, have not been established. Between 2006 and 2008, 32... | 25,223,625 | [
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X-ray spectroscopic study of solvent effects on the ferrous and ferric hexacyanide anions. | We present an Fe Kα resonant inelastic X-ray scattering (RIXS) and X-ray emission (XES) study of ferrous and ferric hexacyanide dissolved in water and ethylene glycol. We observe that transitions below the absorption edge show that the solvent has a distinct effect on the valence electronic structure. In addition, both... | 25,223,627 | [
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Glutaryl-coenzyme A dehydrogenase from Geobacter metallireducens - interaction with electron transferring flavoprotein and kinetic basis of unidirectional catalysis. | Glutaryl-CoA dehydrogenases (GDHs) are FAD containing acyl-CoA dehydrogenases that usually catalyze the dehydrogenation and decarboxylation of glutaryl-CoA to crotonyl-CoA with an electron transferring flavoprotein (ETF) acting as natural electron acceptor. In anaerobic bacteria, GDHs play an important role in the benz... | 25,223,645 | [
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Analysis of Onset Mechanisms of a Sphingosine 1-Phosphate Receptor Modulator Fingolimod-Induced Atrioventricular Conduction Block and QT-Interval Prolongation. | Fingolimod, a sphingosine 1-phosphate (S1P) receptor subtype 1, 3, 4 and 5 modulator, has been used for the treatment of patients with relapsing forms of multiple sclerosis, but atrioventricular conduction block and/or QT-interval prolongation have been reported in some patients after the first dose. In this study, we ... | 25,223,691 | [
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Inhibition of TNF-α in hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy by inhibiting neurohormonal excitation in spontaneously hypertensive rats. | We hypothesized that chronic inhibition of tumor necrosis factor-alpha (TNF-α) in the hypothalamic paraventricular nucleus (PVN) delays the progression of hypertension and attenuates cardiac hypertrophy by up-regulating anti-inflammatory cytokines, reducing pro-inflammatory cytokines (PICs), decreasing nuclear factor-κ... | 25,223,692 | [
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The National Library of Medicine's (NLM) Hazardous Substances Data Bank (HSDB): background, recent enhancements and future plans. | The National Library of Medicine's (NLM) Division of Specialized Information Services (SIS) Toxicology and Environmental Health Information Program is responsible for the management of the online Hazardous Substances Data Bank (HSDB). HSDB, a part of NLM's Toxicology Data Network (TOXNET(®)), is a file of chemical/subs... | 25,223,694 | [
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Single- and Bi-component T2* analysis of tendon before and during tensile loading, using UTE sequences. | To determine if the application of tensile force alters the single- or bi-component T2* values of human tendons as measured on a clinical MRI scanner with ultrashort echo time (UTE sequences and if single- or bi-component T2* values differ when measured with 2D-UTE, 3D-UTE, or 3D-UTE-Cones sequences. Ten tendons were i... | 25,223,714 | [
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Sacral nerve stimulation changes rectal sensitivity and biomechanical properties in patients with irritable bowel syndrome. | Sacral nerve stimulation (SNS) has been demonstrated to alleviate symptoms and improve quality of life in selected patients with irritable bowel syndrome (IBS). The mechanisms of action, however, remain unknown. The aim of the study was to evaluate the effects of SNS on rectal sensitivity and biomechanical properties i... | 25,223,743 | [
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Size misperception among overweight and obese families. | Perception of body size is a key factor driving health behavior. Mothers directly influence children's nutritional and exercise behaviors. Mothers of ethnic minority groups and lower socioeconomic status are less likely to correctly identify young children as overweight or obese. Little evaluation has been done of the ... | 25,223,750 | [
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'Learning disabilities' as a 'black box': on the different conceptions and constructions of a popular clinical entity in Israel. | This article aims to stimulate new thinking about learning disabilities than is customary in local literature. Previous educational and psychological studies concerning learning disabilities regarded them as if they were objective categories with formal definitions and criteria accepted in scholarly literature. Contrar... | 25,223,763 | [
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BRCA1 modulates the autophosphorylation status of DNA-PKcs in S phase of the cell cycle. | Non-homologous end-joining (NHEJ) and homologous recombination (HR) are the two prominent pathways responsible for the repair of DNA double-strand breaks (DSBs). NHEJ is not restricted to a cell-cycle stage, whereas HR is active primarily in the S/G2 phases suggesting there are cell cycle-specific mechanisms that play ... | 25,223,785 | [
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Conjoint propagation and differentiation of human embryonic stem cells to cardiomyocytes in a defined microcarrier spinner culture. | Myocardial infarction is accompanied by a significant loss of cardiomyocytes (CMs). Functional CMs, differentiated from human embryonic stem cells (hESCs), offer a potentially unlimited cell source for cardiac disease therapies and regenerative cardiovascular medicine. However, conventional production methods on monola... | 25,223,792 | [
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Trade-off of ovarian lipids and total body lipids for fecundity and starvation resistance in tropical populations of Drosophila melanogaster. | In Drosophila melanogaster, clines of starvation resistance along a latitudinal gradient (south to north) have been reported in India, which matched with their cline for total body lipids (TL ). Nevertheless, producing too many reserves is likely to be costly and a trade-off might exist with life-history traits. Previo... | 25,223,796 | [
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Urotensin II increases foam cell formation by repressing ABCA1 expression through the ERK/NF-κB pathway in THP-1 macrophages. | Foam cell formation in the arterial wall plays a key role in the development of atherosclerosis. Recent studies showed that Urotensin II (U II) is involved in the pathogenesis of atherosclerosis. Here we examined the effects of human U II on ATP-binding cassette transporter A1 (ABCA1) expression and the underlying mech... | 25,223,800 | [
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[Instent rupture of a saphenous vein graft during percutaneous intervention successfully treated with a covered stent]. | Percutaneous coronary interventions of saphenous vein grafts are associated with an increased risk of periprocedural complications; among these, the rupture of the vein graft is probably the less common and the most dangerous; it is even more exceptional when it occurs on a stented portion of the graft. We report the c... | 25,223,830 | [
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Anti-metastatic immunotherapy based on mucosal administration of flagellin and immunomodulatory P10. | Current therapies against malignant melanoma generally fail to increase survival in most patients, and immunotherapy is a promising approach as it could reduce the dosage of toxic therapeutic drugs. In the present study, we show that an immunotherapeutic approach based on the use of the Toll-like receptor (TLR)-5 ligan... | 25,223,833 | [
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Fixed-dose enoxaparin after bariatric surgery: the influence of body weight on peak anti-Xa levels. | There is lack of data on the pharmacodynamics of low-molecular-weight heparins in obese patients. The aims of this study are to investigate the correlation between anti-factor Xa (anti-Xa) levels and body weight with fixed-dose enoxaparin after bariatric surgery and to investigate the percentage of patients that reach ... | 25,223,871 | [
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Castleman disease of the neck: CT and MR imaging findings. | To characterize the computed tomography (CT) and magnetic resonance imaging (MRI) findings of Castleman disease of the neck. The imaging findings of 21 patients with Castleman disease of the neck were reviewed retrospectively. Of the 21 patients, 16 underwent unenhanced and contrast-enhanced CT scans; 5 underwent unenh... | 25,223,886 | [
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Do poor-responder patients benefit from increasing the daily gonadotropin dose during controlled ovarian hyperstimulation for IVF? | We aim to assess the in vitro fertilization-embryo transfer (IVF-ET) outcome in patients receiving an extremely high 450 daily dose (IU) of gonadotropins during controlled ovarian hyperstimulation (COH) for IVF. Moreover, in those who failed to conceive while using 450 daily dose (IU) of gonadotropins, we aim to evalua... | 25,223,892 | [
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Biogeographical distribution of denitrifying anaerobic methane oxidizing bacteria in Chinese wetland ecosystems. | The discovery of denitrifying anaerobic methane oxidation with nitrite as electron acceptor mediated by 'Candidatus Methylomirabilis oxyfera' connected the biogeochemical carbon and nitrogen cycle in a new way. However, it is important to have a comprehensive understanding about the distribution of M. oxyfera-like bact... | 25,223,900 | [
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Age differences in self-referencing: Evidence for common and distinct encoding strategies. | Although engagement of medial prefrontal cortex (MPFC) underlies self-referencing of information for younger and older adults, the region has not consistently been implicated across age groups for the encoding of self-referenced information. We sought to determine whether making judgments about others as well as the se... | 25,223,905 | [
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... |
Hormones and venous thromboembolism among postmenopausal women. | Abstract Venous thromboembolism (VTE) is a common and potentially fatal disease in postmenopausal women. VTE has emerged as the most prevalent adverse effect of oral estrogens in 50-60-year-old women. Obesity and VTE history can be easily used to identify women at high risk but genetic screening is not cost-effective. ... | 25,223,916 | [
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Noroviruses associated with outbreaks of acute gastroenteritis in the State of Rio Grande do Sul, Brazil, 2004-2011. | Acute gastroenteritis norovirus (NoV) in a country of continental dimensions like Brazil has resulted in under-reporting of the number of outbreaks, as well as the genotypes associated. To demonstrate the role of NoV in outbreaks occurring in the State of Rio Grande do Sul, Southern Brazil, we determined its prevalence... | 25,223,919 | [
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Surgical management of bone metastases: quality of evidence and systematic review. | Surgical management of metastatic bone disease (MBD) is typically reserved for lesions with the highest risk of fracture. However, the high risk of perioperative complications associated with surgery may outweigh the benefits of improved pain and/or function. The goal of this study was to (1) assess the quality of curr... | 25,223,925 | [
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Human fecal microbiome-based biomarkers for colorectal cancer. | Colorectal cancer may develop slowly over years from precursor lesions, and thus screening combined with early diagnosis is the key to disease prevention. Recent studies have elucidated specific traits in the gut microbiome associated with colorectal cancer and suggested that the microbiome may be useful in screening f... | 25,223,933 | [
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Occurrence of multidrug resistance to oral antibiotics among Escherichia coli urine isolates from outpatient departments in Germany: extended-spectrum β-lactamases and the role of fosfomycin. | The in vitro activities of fosfomycin and seven other antibiotics commonly used for oral treatment of urinary tract infections (UTIs) were evaluated for 499 Escherichia coli isolated from urine samples during a nationwide laboratory-based surveillance study in 2010. Overall, the highest resistance rates were found for ... | 25,223,936 | [
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Filarial antigenemia and Loa loa night blood microfilaremia in an area without bancroftian filariasis in the Democratic Republic of Congo. | Implementation of mass drug administration for lymphatic filariasis (LF) has been delayed in central Africa because of incomplete mapping and coendemic loiasis. We mapped two regions in eastern Democratic Republic of Congo that were suspected to have LF. Night blood samples were collected from 2,724 subjects in 30 vill... | 25,223,938 | [
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Usefulness of 11C-methionine-positron emission tomography for the diagnosis of progressive multifocal leukoencephalopathy. | Progressive multifocal leukoencephalopathy (PML) is a subacute demyelinating disease of the brain caused by the JC virus that occurs mainly in immunocompromised patients. The prognosis is very poor. As the lesion looks like non- specific leukoencephalopathy, making a diagnosis at the early stage is very difficult. We r... | 25,223,960 | [
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Peripherally cross-linking the shell of core-shell polymer micelles decreases premature release of physically loaded combretastatin A4 in whole blood and increases its mean residence time and subsequent potency against primary murine breast tumors after IV administration. | Determine the feasibility and potential benefit of peripherally cross-linking the shell of core-shell polymer micelles on the premature release of physically loaded hydrophobic drug in whole blood and subsequent potency against solid tumors. Individual Pluronic F127 polymer micelles (F127 PM) peripherally cross-linked ... | 25,223,962 | [
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Molecular-based isothermal tests for field diagnosis of malaria and their potential contribution to malaria elimination. | In countries where malaria transmission has decreased substantially, thanks to the scale-up of control interventions, malaria elimination may be feasible. Nevertheless, this goal requires new strategies such as the active detection and treatment of infected individuals. As the detection threshold for the currently used... | 25,223,973 | [
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Ganciclovir inhibits human adenovirus replication and pathogenicity in permissive immunosuppressed Syrian hamsters. | Adenovirus infections of immunocompromised patients can develop into deadly multiorgan or systemic disease. The virus is especially threatening for pediatric allogeneic hematopoietic stem cell transplant recipients; according to some studies, 10% or more of these patients succumb to disease resulting from adenovirus in... | 25,224,011 | [
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A multicenter, randomized, controlled clinical trial evaluating the use of dehydrated human amnion/chorion membrane allografts and multilayer compression therapy vs. multilayer compression therapy alone in the treatment of venous leg ulcers. | Venous leg ulcers produce significant clinical and economic burdens on society and often require advanced wound therapy. The purpose of this multicenter, randomized, controlled study is to evaluate the safety and efficacy of one or two applications of dehydrated human amnion/chorion membrane allograft and multilayer co... | 25,224,019 | [
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Evaluation of prognostic scale Thrombolysis In Myocardial Infarction and Killip. An ST-elevation myocardial infarction new scale. | Prognostic systems are complex. So it is necessary to find tools, which are easy to use and have good calibration and discrimination. The objective of this study is to evaluate the usefulness of Killip, Thrombolysis In Myocardial Infarction (TIMI), and age to develop a new prognostic scale for patients with ST-elevatio... | 25,224,025 | [
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Antiarrhythmic effect of lithium in rats after myocardial infarction by activation of Nrf2/HO-1 signaling. | Glycogen synthase kinase-3 (GSK-3) signaling has been shown to play a role in the regulation of nuclear factor erythroid-2-related factor 2 (Nrf2), a master regulator of antioxidant genes, including heme oxygenase-1 (HO-1). We assessed whether lithium, a GSK-3 inhibitor, attenuates cardiac sympathetic reinnervation aft... | 25,224,036 | [
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Nuclear Nrf2 induction by protein transduction attenuates osteoclastogenesis. | It has been reported that reactive oxygen species (ROS) play a role as intracellular signaling molecules in RANKL stimulation. Previously we demonstrated that induction of cytoprotective enzyme expression by Nrf2-gene transfer successfully ameliorated RANKL-dependent osteoclastogenesis. In the present study, we hypothe... | 25,224,039 | [
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Noncardiac surgery in patients with aortic stenosis: a contemporary study on outcomes in a matched sample from the Danish health care system. | Past research has identified aortic stenosis (AS) as a major risk factor for adverse outcomes in noncardiac surgery; however, more contemporary studies have questioned the grave prognosis. To further our understanding of this, the risks of a 30-day major adverse cardiovascular event (MACE) and all-cause mortality were ... | 25,224,044 | [
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HLA-DRA variants predict penicillin allergy in genome-wide fine-mapping genotyping. | Immediate reactions to β-lactams are the most common causes of anaphylactic reactions and can be life-threatening. The few known genetic factors influencing these reactions suggest a link with atopy and inflammation. We performed a fine-mapping genome-wide association study of the genetic predictors of β-lactam allergy... | 25,224,099 | [
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The therapeutic or prophylactic effect of exogenous melatonin against depression and depressive symptoms: a systematic review and meta-analysis. | Circadian- and sleep disturbances may be central for understanding the pathophysiology and treatment of depression. The effect of melatonin on depression/depressive symptoms has been investigated previously. This systematic review assesses the current evidence of a therapeutic- and prophylactic effect of melatonin in a... | 25,224,106 | [
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Predictors of poor sleep quality and excessive daytime sleepiness in peritoneal dialysis patients. | To explore the possible impact factors on daytime sleepiness among peritoneal patients from a single center in China. A cross-sectional study was conducted in 98 prevalent peritoneal dialysis (PD) patients using both the Pittsburgh Sleep Quality Index (PSQI) questionnaire of sleep quality and the Epworth Sleepiness Sca... | 25,224,151 | [
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Different strategies underlying uncertain decision making: higher executive performance is associated with enhanced feedback-related negativity. | The aim of the present study was to investigate the role of executive functions (EFs) in different strategies underlying risky decision making. Adult participants from a nonclinical sample were assigned to low or high EF groups based on their performance on EF tasks measuring shifting, updating, and inhibition. ERPs we... | 25,224,177 | [
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Review of global rotavirus strain prevalence data from six years post vaccine licensure surveillance: is there evidence of strain selection from vaccine pressure? | Comprehensive reviews of pre licensure rotavirus strain prevalence data indicated the global importance of six rotavirus genotypes, G1P[8], G2P[4], G3P[8], G4P[8], G9P[8] and G12P[8]. Since 2006, two vaccines, the monovalent Rotarix (RV1) and the pentavalent RotaTeq (RV5) have been available in over 100 countries world... | 25,224,179 | [
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Effective treatment of congestive heart failure using adaptive servo-ventilation in an end-stage renal disease patient on hemodialysis. | A 61-year-old man who was being treated with hemodialysis (HD) for end-stage renal disease presented with symptoms of severe congestive heart failure (CHF). Removing excess intravascular fluid during HD was difficult due to the patient's chronic hypotension induced by severe left ventricular (LV) dysfunction. The appli... | 25,224,193 | [
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Lung Nocardia elegans infection diagnosed on matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). | A 73-year-old man with adultonset Still's disease developed a high fever, coughing, dyspnea and bloody sputum and was therefore admitted to our hospital. Thoracic X-ray and CT scans revealed oval lesions in the bilateral lungs. A bacterial isolate from the sputum was identified to be Nocardia elegans (N. elegans) on co... | 25,224,198 | [
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A fatal case of acute myocardial infarction following the improvement of influenza A(H1N1)pdm2009-related acute myocarditis. | A 52-year-old Indian man was hospitalized due to dyspnea and a high fever caused by influenza A(H1N1)pdm2009. Elevated cardiac enzymes, a chest X-ray showing bilateral infiltrative shadows, cardiomegaly and pleural effusion and echocardiography indicating diffuse hypokinesis of the left ventricle suggested cardiac fail... | 25,224,206 | [
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Self-regulated left-right asymmetric expression of Pitx2c in the developing mouse limb. | The transcription factor Pitx2c is expressed in primordial visceral organs in a left-right (L-R) asymmetric manner and executes situs-specific morphogenesis. Here we show that Pitx2c is also L-R asymmetrically expressed in the developing mouse limb. Human PITX2c exhibits the same transcriptional activity in the mouse l... | 25,224,222 | [
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Effects of van der Waals interaction and electric field on the electronic structure of bilayer MoS2. | The modification of the electronic structure of bilayer MoS2 by an external electric field can have potential applications in optoelectronics and valleytronics. Nevertheless, the underlying physical mechanism is not clearly understood, especially the effects of the van der Waals interaction. In this study, the spin orb... | 25,224,268 | [
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Tumor-suppressive miR148a is silenced by CpG island hypermethylation in IDH1-mutant gliomas. | IDH1/2-mutant gliomas harbor a distinct glioma-CpG island methylation phenotype (G-CIMP) that may promote the initiation and progression of secondary pathway gliomas by silencing tumor-suppressive genes. The potential role of tumor-suppressive microRNAs (miRNA; miR) in this process is not understood. To identify potent... | 25,224,277 | [
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Starch-g-Poly-(N, N-dimethyl acrylamide-co-acrylic acid): an efficient Cr (VI) ion binder. | Synthesis of Starch-g-(Poly N, N-dimethylacrylamide-co-acrylic acid) was carried out by solution polymerization technique using potassium perdisulfate (K(2)S(2)O(8)) as the initiator. The graft copolymer was characterized by measuring molecular weight, using size exclusion chromatography (SEC), FTIR spectroscopy and X-... | 25,224,290 | [
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-0.01490411,
-0.08673982,
... |
Uncertain diagnosis of fabry disease in patients with neuropathic pain, angiokeratoma or cornea verticillata: consensus on the approach to diagnosis and follow-up. | Individuals with neuropathic pain, angiokeratoma (AK) and/or cornea verticillata (CV) may be tested for Fabry disease (FD). Classical FD is characterised by a specific pattern of these features. When a patient presents with a non-specific pattern, the pathogenicity of a variant in the α-galactosidase A (GLA) gene may b... | 25,224,312 | [
-0.2047229,
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0.08044182,
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0.07384143,
0.02190104,
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0.2136965,
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... |
Chemical reaction-induced multi-molecular polarization (CRIMP). | Here we present a novel hyperpolarization method, Chemical Reaction-Induced Multi-molecular Polarization (CRIMP), which could be applied to the study of several in vivo processes simultaneously including glycolysis, TCA cycle, fatty acid synthesis and pH mapping. Through the use of non-enzymatic decarboxylation, we gen... | 25,224,323 | [
-0.3516383,
0.1731711,
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0.3613003,
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0.2380238,
-0.03744469,
0.2186352,
-0.07273389,
0.0... |
Alternating current cloud point extraction on a microchip: the effect of electrode geometry. | We report on the effect of electrode geometry on alternating current cloud point extraction (ACPE). ACPE is a technique utilized to extract membrane-associated biomolecules in an electrode-integrated microfluidic channel. In this study, we investigated the effect of gap size (4∼22 μm) between microband electrodes on AC... | 25,224,325 | [
-0.2732796,
0.1054325,
-0.2100158,
-0.04499127,
0.06730957,
0.02862787,
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0.2772833,
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0.1703832,
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0.02110094,
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-0.4372443,
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-0.1446646,
-0.02091499,
0.2043906,
0.2164224,
-0.00140766... |
Occupational exposure to N,N-dimethylformamide in the summer and winter. | We evaluated total body burden of N,N-dimethylformamide (DMF) taken through the lung and skin by personal exposure of workers to DMF and urinalysis of N-methylformamide (NMF) and N-acetyl-S(N-methylcarbamoyl)-cysteine (AMCC). A total of 270 workers were engaged in four different jobs in a workplace distant from main pr... | 25,224,331 | [
-0.3534797,
0.1362351,
0.08052585,
0.000654406,
0.243703,
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0.01012481,
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0.1095684,
0.1943454,
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0.01417203,
-0.1218719,
0.2495667,
-0.2699155,
... |
Serum miRNA profiling identifies miR-150/30a as potential biomarker for workers with damaged nerve fibers from carbon disulfide. | As crucial small regulatory molecules, serum microRNAs (miRNAs) have been widely identified as potential noninvasive biomarkers. To survey and identify serum miRNAs associated with workers who had experienced injury to their nerve system from carbon disulfide (CS2), we profiled abnormally expressed miRNAs using the mic... | 25,224,332 | [
-0.2902384,
0.4688387,
0.2132042,
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0.004678068,
0.04176643,
-0.3109711,
0.2756948,
0.02136662,
... |
PET and NIR optical imaging using self-illuminating (64)Cu-doped chelator-free gold nanoclusters. | Self-illuminating fluorescence imaging without autofluorescence background interference has recently aroused more research interests in molecular imaging. Currently, only a few self-illuminating probes were developed, based mainly on toxic quantum dots such as CdSe, CdTe. Herein, we report a novel design of nontoxic se... | 25,224,367 | [
-0.2932115,
0.1777999,
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0.3437923,
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-0.03807206,
0.02543029,
0.1559435,
-0.08393007,... |
Long-lasting uveitis remission and hearing loss recovery after rituximab in Vogt-Koyanagi-Harada disease. | Vogt-Koyanagi-Harada disease (VKHD) is a multisystemic disorder characterized by granulomatous panuveitis variably combined with T cell-mediated neurologic and cutaneous manifestations. Early and aggressive treatment with systemic corticosteroids is the mainstay of treatment for VKHD. Additional use of immunosuppressan... | 25,224,382 | [
-0.08524466,
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0.05026522,
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0.07539492,
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-0.1256455,
-0.1254598,
-0.05938176,
-0.00830087,
0.103061,
0.1148324,
-0.053683... |
Thioester-containing proteins of the tick Ixodes ricinus: gene expression, response to microbial challenge and their role in phagocytosis of the yeast Candida albicans. | The ability of ticks to act as vectors for a wide range of serious human and animal infectious diseases is apparently linked to the insufficiency of the tick immune system to effectively eliminate pathogens they transmit. At the tick-pathogen interface, an important role is presumably played by components of an ancient... | 25,224,405 | [
0.3717678,
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-0.0350423,
0.1742424,
0.1587116,
0.2222874,
0.18... |
Brain-derived neurotrophic factor in urinary continence and incontinence. | Urinary incontinence adversely affects quality of life and results in an increased financial burden for the elderly. Accumulating evidence suggests a connection between neurotrophins, such as brain-derived neurotrophic factor (BDNF), and lower urinary tract function, particularly with regard to normal physiological fun... | 25,224,451 | [
0.07912903,
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0.2417358,
0.03492305,
... |
The expression pattern of systemically injected AAV9 in the developing mouse retina is determined by age. | Systemic delivery of AAV9 offers the potential for widespread and efficient gene delivery to the retina, and may thus be a useful approach for treatment of disease where intraocular injections are not possible, for syndromes affecting multiple organs, or where early intervention is required. The expression resulting fr... | 25,224,467 | [
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0.1824317,
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0.03162726,
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-0.2809108,
-0.3057772,
0.1092964,
0.2763165,
0.2749429,
-0.0241669... |
Potential roles of noncoding RNAs in environmental epigenetic transgenerational inheritance. | "Epigenetic transgenerational inheritance" (ETI) has been defined as germline (sperm or egg) transmission of epigenetic information between generations in the absence of direct exposures or genetic manipulations. Among reported cases of ETI in mammals, the majority are induced by environmental factors, including enviro... | 25,224,488 | [
-0.2024506,
0.2141749,
0.2172172,
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0.03963898,
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0.0449404,
0.0119924,
0.3745727,
0.1730159,
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0.2109623,
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0.09274382,
0.1807852,
-0.2555049,
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0.3056229,
-0.3993218,
-... |
Phosphorylation regulates mycobacterial proteasome. | Mycobacterium tuberculosis possesses a proteasome system that is required for the microbe to resist elimination by the host immune system. Despite the importance of the proteasome in the pathogenesis of tuberculosis, the molecular mechanisms by which proteasome activity is controlled remain largely unknown. Here, we de... | 25,224,505 | [
0.1388167,
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0.02654656,
0.0624781,
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0.09605452,
0.04095913,
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0.09848903,
0.07629038,
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-0.4415462,
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0.2811362,
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0.1963204,
0.1976446,
-0.06326692,
... |
Gender issues in the neurobiology of epilepsy: a clinical perspective. | A patient's hormonal milieu contributes to the timing of emergence of several epilepsy syndromes that are known to begin at puberty and recede with the end of reproductive potential. One's hormonal balance at any particular moment contributes to seizure occurrence in both men and women. The best studied condition, cata... | 25,224,522 | [
-0.2307799,
0.2806855,
0.1163784,
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0.1392695,
0.1278102,
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0.05957145,
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0.03577557,
-0.2489767,
-0.2102709,
0.362622,
-0.1387279,
... |
Increased common atrioventricular valve tenting is a risk factor for progression to severe regurgitation in patients with a single ventricle with unbalanced atrioventricular septal defect. | Significant atrioventricular valve regurgitation (AVVR) increases mortality in patients with unbalanced atrioventricular septal defects (uAVSDs) and a single ventricle. We tested the hypothesis that abnormal leaflet tethering is associated with progressive AVVR in patients with a single ventricle with uAVSD. We retrosp... | 25,224,553 | [
-0.2784117,
-0.359809,
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0.4509762,
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0.1112944,
0.2503565,
0.03564023,
0.1746729,
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0.07064983,
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0.04948716,
-0.4361668,
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0.1614473,
-0.3612701,
... |
Hallucinogen-like effects of 2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol (25CN-NBOH), a novel N-benzylphenethylamine with 100-fold selectivity for 5-HT₂A receptors, in mice. | 2-([2-(4-cyano-2,5-dimethoxyphenyl)ethylamino]methyl)phenol (25CN-NBOH) is structurally similar to N-benzyl substituted phenethylamine hallucinogens currently emerging as drugs of abuse. 25CN-NBOH exhibits dramatic selectivity for 5-HT2A receptors in vitro, but has not been behaviorally characterized. 25CN-NBOH was com... | 25,224,567 | [
-0.3759393,
-0.1287217,
-0.5481579,
-0.6480561,
0.2042955,
0.2011108,
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0.1280741,
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0.2558926,
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0.3778467,
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0.2723906,
0.01868358,
0.2884815,
0.2392025,
-0.33... |
Evaluation of the 5 and 8 pH point titration methods for monitoring anaerobic digesters treating solid waste. | Simple titration methods certainly deserve consideration for on-site routine monitoring of volatile fatty acid (VFA) concentration and alkalinity during anaerobic digestion (AD), because of their simplicity, speed and cost-effectiveness. In this study, the 5 and 8 pH point titration methods for measuring the VFA concen... | 25,224,566 | [
0.002622249,
0.1231279,
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0.05731919,
0.005199161,
0.00587779,
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0.3669186,
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0.003517105,
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0.3329438,
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0.1800483,
0.1161885,
0.23142,
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... |
Current approaches for RNA labeling in vitro and in cells based on click reactions. | Over recent years, click reactions have become recognized as valuable and flexible tools to label biomacromolecules such as proteins, nucleic acids, and glycans. Some of the developed strategies can be performed not only in aqueous solution but also in the presence of cellular components, as well as on (or even in) liv... | 25,224,574 | [
-0.1774847,
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0.219264,
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0.1350903,
0.3928902,
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-0.2164193,
-0... |
Maternal directiveness in childhood survivors of acute lymphoblastic leukemia. | Parental intrusiveness is associated with internalizing problems in healthy children. Given the unique demands that childhood cancer places on parents, it is important to determine whether intrusiveness operates differently in survivors of childhood cancer. The current study tested whether cancer survivorship moderates... | 25,224,583 | [
-0.4144405,
0.3342427,
-0.364275,
-0.2956074,
0.1597455,
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0.1239562,
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0.200754,
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0.2760574,
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0.04793498,
0.2833051,
0.04185458,
0.05117969,
... |
Retrospective analysis of spinal trauma in patients with ankylosing spondylitis: a descriptive study in Indian population. | This study aims to understand the demographics, mode of trauma, hospital stay, complications, neurological improvement, mortality and expenditure incurred by Indian patients with spinal trauma and ankylosing spondylitis (AS). Retrospective analysis of the patient data admitted to a tertiary referral hospital from 2008 ... | 25,224,600 | [
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0.1102311,
0.1655733,
0.0390709,
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0.009913157,
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0.2524449,
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0.07678484,
-0.008674565,
-0.2401752,
-0.247924,
0.04963532,
0.1001215,
-0.10510... |
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