title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Illness representation and treatment beliefs in liver transplantation: an exploratory qualitative study. | The objective of this study was to gain detailed insight concerning liver transplanted patients' representations about transplantation, graft rejection and immunosuppressive drugs to adapt the educational follow-up. Semi-structured interviews were conducted with 8 patients. Each interview was recorded and fully transcr... | 25,220,233 | [
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Consumption of vegetables and fruits and risk of subtypes of head-neck cancer in the Netherlands Cohort Study. | There is limited prospective data on the relationship between consumption of vegetables and fruits and the risk of head-neck cancer (HNC) subtypes [i.e., oral cavity cancer (OCC), oro-/hypopharyngeal cancer (OHPC) and laryngeal cancer (LC)]. Therefore, we investigated these associations within the Netherlands Cohort St... | 25,220,255 | [
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The association between family affluence and smoking among 15-year-old adolescents in 33 European countries, Israel and Canada: the role of national wealth. | To examine the role of national wealth in the association between family affluence and adolescent weekly smoking, early smoking behaviour and weekly smoking among former experimenters. Data were used from the Health Behaviour in School-aged Children (HBSC) study conducted in 2005/2006 in 35 countries from Europe and No... | 25,220,260 | [
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Cardiac rehabilitation in Latin America. | This article provides a description of the status of cardiovascular (CV) rehabilitation (CVR) in Latin America (LA) and the potential impact on CV disease in the region. We discuss the insufficient number of CVR programs in the region and describe the components of CVR that are more commonly available, like exercise in... | 25,220,257 | [
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Air pollution, avoidance behaviour and children's respiratory health: evidence from England. | Despite progress in air pollution control, concerns remain over the health impact of poor air quality. Governments increasingly issue air quality information to enable vulnerable groups to avoid exposure. Avoidance behaviour potentially biases estimates of the health effects of air pollutants. But avoidance behaviour i... | 25,220,266 | [
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Reference characterisation of sound speed and attenuation of the IEC agar-based tissue-mimicking material up to a frequency of 60 MHz. | To support the development of clinical applications of high-frequency ultrasound, appropriate tissue-mimicking materials (TMMs) are required whose acoustic properties have been measured using validated techniques. This paper describes the characterisation of the sound speed (phase velocity) and attenuation coefficient ... | 25,220,268 | [
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Computed ultrasound tomography in echo mode for imaging speed of sound using pulse-echo sonography: proof of principle. | The limitations of diagnostic echo ultrasound have motivated research into novel modalities that complement ultrasound in a multimodal device. One promising candidate is speed of sound imaging, which has been found to reveal structural changes in diseased tissue. Transmission ultrasound tomography shows speed of sound ... | 25,220,274 | [
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Standard plane localization in ultrasound by radial component model and selective search. | Acquisition of the standard plane is crucial for medical ultrasound diagnosis. However, this process requires substantial experience and a thorough knowledge of human anatomy. Therefore it is very challenging for novices and even time consuming for experienced examiners. We proposed a hierarchical, supervised learning ... | 25,220,278 | [
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Emerging roles for pharmacists in clinical implementation of pharmacogenomics. | Pharmacists are uniquely qualified to play essential roles in the clinical implementation of pharmacogenomics. However, specific responsibilities and resources needed for these roles have not been defined. We describe roles for pharmacists that emerged in the clinical implementation of genotype-guided clopidogrel thera... | 25,220,280 | [
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Topical use of citric acid for wound bed preparation. | Wound bed preparation is the management of a wound in order to accelerate endogenous healing or to facilitate the effectiveness of split-skin grafting. The formation of a healthy wound bed is a prerequisite to the use of advanced wound care products. Unless this is achieved, even the most sophisticated and expensive ma... | 25,220,286 | [
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Novel (cyanamide)Zn(II) complexes and zinc(ii)-mediated hydration of the cyanamide ligands. | The cyanamides NCNR2 (R2 = Me2, Ph2, C5H10) react with ZnX2 (X = Cl, Br, I) in a 2 : 1 molar ratio at RT, giving a family of zinc(ii) complexes [ZnX2(NCNR2)2] (R2 = Me2, X = Cl , X = Br , X = I ; R2 = C5H10, X = Cl , X = Br ; X = I ; R2 = Ph2, X = Cl , X = Br , X = I ; 75-92% yields). Complexes and undergo ligand redis... | 25,220,287 | [
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Cysteine rhenium colloid: a novel radiocolloid for identifying sentinel lymph nodes in breast cancer surgery. | Medical isotopes are required for sentinel node lymphoscintigraphy in breast cancer, but are in critical shortage. Our center uses a modification of the standard SC, called CRC, that has been shown to require less medical isotope for the same procedure. Our objective was to determine if there was a significant differen... | 25,220,300 | [
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Microbial gardening in the ocean's twilight zone: detritivorous metazoans benefit from fragmenting, rather than ingesting, sinking detritus: fragmentation of refractory detritus by zooplankton beneath the euphotic zone stimulates the harvestable production of labile and nutritious microbial biomass. | Sinking organic particles transfer ∼10 gigatonnes of carbon into the deep ocean each year, keeping the atmospheric CO2 concentration significantly lower than would otherwise be the case. The exact size of this effect is strongly influenced by biological activity in the ocean's twilight zone (∼50-1,000 m beneath the sur... | 25,220,362 | [
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Expression of coinhibitory receptors on T cells in the microenvironment of usual vulvar intraepithelial neoplasia is related to proinflammatory effector T cells and an increased recurrence-free survival. | Human papillomavirus-induced usual-type vulvar intraepithelial neoplasia (uVIN) are infiltrated by immune cells but apparently not cleared. A potential explanation for this is an impaired T cell effector function by an immunesuppressive milieu, coinfiltrating regulatory T cells or the expression of coinhibitory molecul... | 25,220,367 | [
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Use of indocyanine green during robot-assisted ureteral reconstructions. | Although there are reports of robot-assisted ureteral reconstructions (RURs) with excellent safety and efficacy, the procedures remain technically challenging. In the robotic setting the surgeon must rely on visual cues in the absence of tactile feedback. Indocyanine green (ICG) is a dye that can be visualized under ne... | 25,220,372 | [
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Synthesis and crystal structure of a series of incommensurately modulated composite oxohalide compounds. | Transparent, needle-like single crystals of the isostructural compounds [Sb4O7+3δX4][Zn3]1+δ (X = Cl, Br, I) δ ≈ 0.2 were obtained from chemical reactions in evacuated and sealed silica tubes. First, the average structure was solved in P21/n but the model refined poorly and a lowering of the symmetry to the 3 + 1 dimen... | 25,220,376 | [
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The UPS and downs of cholesterol homeostasis. | An emerging theme in the regulation of cholesterol homeostasis is the role of the ubiquitin proteasome system (UPS), through which proteins are ubiquitylated and then degraded in response to specific signals. The UPS controls all aspects of cholesterol metabolism including its synthesis, uptake, and efflux. We review h... | 25,220,377 | [
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Cpeb4-mediated translational regulatory circuitry controls terminal erythroid differentiation. | While we have considerable understanding of the transcriptional networks controlling mammalian cell differentiation, our knowledge of posttranscriptional regulatory events is very limited. Using differentiation of primary erythroid cells as a model, we show that the sequence-specific mRNA-binding protein Cpeb4 is stron... | 25,220,394 | [
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Suppression of autophagy augments the radiosensitizing effects of STAT3 inhibition on human glioma cells. | Radiotherapy is an essential component of the standard therapy for newly diagnosed glioblastoma. To increase the radiosensitivity of glioma cells is a feasible solution to improve the therapeutic effects. It has been suggested that inhibition of signal transducer and activator of transcription 3 (STAT3) can radiosensit... | 25,220,423 | [
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Rapid End-Group Modification of Polysaccharides for Biomaterial Applications in Regenerative Medicine. | Polysaccharides have emerged as important functional materials because of their unique properties such as biocompatibility, biodegradability, and availability of reactive sites for chemical modifications to optimize their properties. The overwhelming majority of the methods to modify polysaccharides employ random chemi... | 25,220,432 | [
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The incidence and risk factors of severe retinopathy of prematurity in extremely low birth weight infants in Turkey. | The aim of this study was to identify the incidence of severe retinopathy of prematurity (ROP) requiring laser treatment and the overall incidence of ROP in extremely low birth weight (ELBW) infants, and to evaluate the associated risk factors for developing severe ROP in ELBW infants in Turkey. This retrospective, cas... | 25,220,443 | [
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κB-Ras proteins regulate both NF-κB-dependent inflammation and Ral-dependent proliferation. | The transformation of cells generally involves multiple genetic lesions that undermine control of both cell death and proliferation. We now report that κB-Ras proteins act as regulators of NF-κB and Ral pathways, which control inflammation/cell death and proliferation, respectively. Cells lacking κB-Ras therefore not o... | 25,220,458 | [
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P7C3 neuroprotective chemicals block axonal degeneration and preserve function after traumatic brain injury. | The P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration. We now show that P7C3 molecules additionally preserve axonal integrity after injury, before neuronal cell death occurs, in a rodent model of blast-mediated traumatic brain injury (TBI). T... | 25,220,467 | [
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Early rehabilitation after total knee replacement surgery: a multicenter, noninferiority, randomized clinical trial comparing a home exercise program with usual outpatient care. | To determine, at 6 weeks postsurgery, if a monitored home exercise program (HEP) is not inferior to usual care rehabilitation for patients undergoing primary unilateral total knee replacement (TKR) surgery for osteoarthritis. We conducted a multicenter, randomized clinical trial. Patients ages 45-75 years were allocate... | 25,220,488 | [
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A fluorescence-based method for cyanate analysis in ethanol/water media: correlation between cyanate presence and ethyl carbamate formation in sugar cane spirit. | Based on the fluorescence properties of 2,4-(1H,3H)-quinazolinedione, a product of the reaction between cyanate and 2-aminobenzoic acid, a simple, sensitive, selective, and reproducible method for the cyanate analysis in aqueous ethanolic media is proposed. In this method, λ(exc) and λ(em) are 310 and 410 nm, respectiv... | 25,220,490 | [
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Cyclin A2 and its associated kinase activity are required for optimal induction of progesterone receptor target genes in breast cancer cells. | A role for the cell cycle protein cyclin A2 in regulating progesterone receptor (PR) activity is emerging. This study investigates the role of cyclin A2 in regulating endogenous PR activity in T47D breast cancer cells by depleting cyclin A2 expression and measuring PR target genes using q-RT-PCR. Targets examined inclu... | 25,220,500 | [
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Selenium status in elderly: relation to cognitive decline. | Studies show that decreased antioxidant system is related to cognitive decline. Thus we aimed to measure selenium (Se) status in Alzheimer's disease (AD) and mild cognitive impairment (MCI) elderly and compared them with a control group (CG). 27 AD, 17 MCI and 28 control elderly were evaluated. Se concentration was det... | 25,220,532 | [
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Trifecta and optimal perioperative outcomes of robotic and laparoscopic partial nephrectomy in surgical treatment of small renal masses: a multi-institutional study. | To compare the perioperative outcomes of robotic partial nephrectomy (RPN) with laparoscopic PN (LPN) performed for small renal masses (SRMs), in a large multi-institutional series and to define a new composite outcome measure, termed 'optimal outcome' for the RPN group. Retrospective review of 2392 consecutive cases o... | 25,220,543 | [
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Clinical supervision: the state of the art. | Since the recognition of clinical supervision as a distinct professional competence and a core competence, attention has turned to ensuring supervisor competence and effective supervision practice. In this article, we highlight recent developments and the state of the art in supervision, with particular emphasis on the... | 25,220,545 | [
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Elevated β-lactam concentrations associated with neurological deterioration in ICU septic patients. | Although β-lactams are considered to have a safe therapeutic profile, neurotoxicity has been reported. The aim of this study was to assess the association between β-lactam concentrations and neurological alterations in septic ICU patients. Retrospective study on all ICU patients who were treated with meropenem (MEM), p... | 25,220,556 | [
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0.242... |
Imitation of phase I oxidative metabolism of anabolic steroids by titanium dioxide photocatalysis. | The aim of this study was to investigate the feasibility of titanium dioxide (TiO2) photocatalysis for oxidation of anabolic steroids and for imitation of their phase I metabolism. The photocatalytic reaction products of five anabolic steroids were compared to their phase I in vitro metabolites produced by human liver ... | 25,220,585 | [
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Antitumor action of a novel histone deacetylase inhibitor, YF479, in breast cancer. | Accumulating evidence demonstrates important roles for histone deacetylase in tumorigenesis (HDACs), highlighting them as attractive targets for antitumor drug development. Histone deactylase inhibitors (HDACIs), which have shown favorable anti-tumor activity with low toxicity in clinical investigations, are a promisin... | 25,220,594 | [
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Facile and scalable synthesis of nanoporous materials based on poly(ionic liquid)s. | A simple, fast, sustainable, and scalable strategy to prepare nanoporous materials based on poly(ionic liquid)s (PILs) is presented. The synthetic strategy relies on the radical polymerization of crosslinker-type ionic liquid (IL) monomers in the presence of an analogous IL, which acts as a porogenic solvent. This IL c... | 25,220,614 | [
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Mediation analysis when a continuous mediator is measured with error and the outcome follows a generalized linear model. | Mediation analysis is a popular approach to examine the extent to which the effect of an exposure on an outcome is through an intermediate variable (mediator) and the extent to which the effect is direct. When the mediator is mis-measured, the validity of mediation analysis can be severely undermined. In this paper, we... | 25,220,625 | [
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Effect of organic toxicants on the activity of denitrifying granular sludge. | Denitrification plays a key role in the biological nitrogen removal from the wastewater using granular sludge as the integral part of a high-rate denitrification technology. It is helpful to evaluate the effect of typical organic toxicants on the activity of denitrifying granular sludge for the application of denitrifi... | 25,220,622 | [
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Immunohistochemical expression of VDR is associated with reduced integrity of tight junction complex in psoriatic skin. | Cell junctions are crucial for the formation and maintenance of the paracellular barrier and for cell polarity in simple epithelia and endothelia. Altered localization and formation of tissue junction proteins in the epidermis have been described in plaque-type psoriasis. Vitamin D receptor (VDR) is a nuclear hormone i... | 25,220,655 | [
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Sleep duration and the risk of future lipid profile abnormalities in middle-aged men: the Kansai Healthcare Study. | Although short sleep duration has been reported to be associated with future cardiometabolic diseases, it is not fully understood whether sleep duration is prospectively associated with the risk of each lipid profile abnormality. Subjects were nondiabetic Japanese, 40-55 years of age, who were not taking oral lipid-low... | 25,220,668 | [
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Kinematic analysis of diseased and adjacent segments in degenerative lumbar spondylolisthesis. | Degenerative spondylolisthesis is a common pathologic condition that leads to lumbar instability and significant clinical symptoms. The effect of this pathology on adjacent lumbar motion segments, however, has not yet been studied. To characterize the motion characteristics of lumbar degenerative spondylolisthesis at b... | 25,220,670 | [
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Factors influencing risky decision-making in patients with cerebral infarction. | Numerous studies have found that the framing effect is common in medical scenarios, but few studies have examined the influence of the framing effect upon thrombolytic therapy for cerebral infarction. In this study, 1040 inpatients and outpatients in the department of neurology were recruited to explore whether there i... | 25,220,685 | [
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0.3784254,
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0.039678... |
Socio-economic position and cardiovascular risk in rural Indian adolescents: evidence from the Andhra Pradesh children and parents study (APCAPS). | This study examined association between socio-economic position and cardiovascular risk factors in adolescents to investigate whether childhood socio-economic position is a risk factor for future cardiovascular disease, independently of adult behaviours. Participants (n = 1128, 46% girls, aged 13-18 years) were members... | 25,220,689 | [
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Differences in acid-induced currents between oxytocin-mRFP1 and vasopressin-eGFP neurons isolated from the supraoptic and paraventricular nuclei of transgenic rats. | The hypothalamic supraoptic nucleus (SON) and paraventricular nucleus (PVN) consists of two types of magnocellular neurosecretory cells, oxytocin (OXT) and arginine vasopressin (AVP). We generated and characterized rats that express an OXT-monomeric red fluorescent protein 1 (mRFP1) and an AVP-enhanced green fluorescen... | 25,220,704 | [
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Potassium channel Kv2.1 is regulated through protein phosphatase-1 in response to increases in synaptic activity. | The functional stability of neurons in the face of large variations in both activity and efficacy of synaptic connections suggests that neurons possess intrinsic negative feedback mechanisms to balance and tune excitability. While NMDA receptors have been established to play an important role in glutamate receptor-depe... | 25,220,706 | [
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Resveratrol synergistically enhances the effect of etoposide in HNSCC cell lines. | Resveratrol shows a growth inhibitory effect in head and neck squamous cell carcinoma (HNSCC) cell lines and acts synergistically in combination with etoposide in three cell lines via the induction of apoptotic and necrotic cell death. In patients with recurrent/distant HNSCC, one of the limited treatment options is et... | 25,220,729 | [
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Risk of cervical cancer in women with autoimmune diseases, in relation with their use of immunosuppressants and screening: population-based cohort study. | Severely immunosuppressed individuals have a strongly increased risk of cervical cancer. In patients with autoimmune diseases (AID), who have defects in their immune system and receive immunosuppressants, the risk of cervical cancer is less clear. We conducted a cohort study, using Danish nationwide population-based re... | 25,220,731 | [
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Informal sources of supervision in clinical training. | Although formal, assigned supervision is a potent source of learning and guidance for psychotherapy trainees, many beginning psychotherapists use other, informal sources of supervision or consultation for advice and support. Results of an online survey of beginning trainees (N = 146) indicate that other than their form... | 25,220,738 | [
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Seminal fluid and immune adaptation for pregnancy--comparative biology in mammalian species. | Seminal fluid delivered to the female reproductive tract at coitus not only promotes the survival and fertilizing capacity of spermatozoa, but also contains potent signalling agents that influence female reproductive physiology to improve the chances of conception and reproductive success. Male to female seminal fluid ... | 25,220,746 | [
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Aesthetic adjuncts with orthognathic surgery. | Traditional orthognathic surgery aligns the patient's bony jaws into a desired, more appropriate position but may leave other cosmetic issues unaddressed. Soft tissue deformities may be treated concomitantly with orthognathic surgery, including soft tissue augmentation (fillers), reduction (liposuction), hard tissue au... | 25,220,751 | [
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A monolithic and flexible fluoropolymer film microreactor for organic synthesis applications. | A photocurable and viscous fluoropolymer with chemical stability is a highly desirable material for fabrication of microchemical devices. Lack of a reliable fabrication method, however, limits actual applications for organic reactions. Herein, we report fabrication of a monolithic and flexible fluoropolymer film micror... | 25,220,762 | [
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Altered functional magnetic resonance imaging responses to nonpainful sensory stimulation in fibromyalgia patients. | Fibromyalgia (FM) is a disorder characterized by chronic pain and enhanced responses to acute noxious events. However, the sensory systems affected in FM may extend beyond pain itself, as FM patients show reduced tolerance to non-nociceptive sensory stimulation. Characterizing the neural substrates of multisensory hype... | 25,220,783 | [
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Antioxidant and antimicrobial carboxymethyl cellulose films containing Zataria multiflora essential oil. | The present study describes the physical, antioxidant, and antimicrobial properties of biodegradable films prepared by incorporating different concentrations (1, 2, and 3% v/v) of Zataria multiflora Boiss (avishan-e shirazi) essential oil (ZEO) into carboxymethyl cellulose (CMC) film. The films' tensile strength, elong... | 25,220,790 | [
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Nanoplasmonic biosensor: detection and amplification of dual bio-signatures of circulating tumor DNA. | Circulating tumor DNA (ctDNA) bearing tumor-specific mutation and methylation are promising biomarkers for noninvasive cancer assessment. However, existing methods for ctDNA detection are restricted to genetic mutations. Recently, nanoplasmonics has emerged as a platform for one-step dual detection with high sensitivit... | 25,220,802 | [
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On the chemistry of activation of a commercial carbon-supported PtRu electrocatalyst for the methanol oxidation reaction. | Although potential cycling has been widely used to activate PtRu electrocatalysts for methanol oxidation, little is known about the molecular/atomic level chemistry involved and also what constitutes the optimal activation. This important question is addressed herein by in situ attenuated total reflection-surface enhan... | 25,220,804 | [
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Activity-dependent gating of calcium spikes by A-type K+ channels controls climbing fiber signaling in Purkinje cell dendrites. | In cerebellar Purkinje cell dendrites, heterosynaptic calcium signaling induced by the proximal climbing fiber (CF) input controls plasticity at distal parallel fiber (PF) synapses. The substrate and regulation of this long-range dendritic calcium signaling are poorly understood. Using high-speed calcium imaging, we ex... | 25,220,810 | [
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A human morphologically normal spermatozoon may have noncondensed chromatin. | According to numerous assisted reproductive medicine practitioners, semen with normal characteristics might not require further investigation. However, on the scale of the individual spermatozoon, it is well known that normal morphology does not guarantee optimal nuclear quality. Here, for 20 patients with normal sperm... | 25,220,830 | [
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Correlation between point-of-care platelet function testing and bleeding after coronary angiography according to two different definitions for bleeding. | Platelet function testing could be useful when assessing the risk for bleeding during treatment with antiplatelet drugs. This has been indicated in several studies, including the Antiplatelet Therapy for Reduction of Myocardial Damage During Angioplasty-Bleeding (ARMYDA-BLEEDS) study, which demonstrated that testing wi... | 25,220,849 | [
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Talar neck fracture-a rare but important complication following subtalar arthroereisis. | Subtalar arthroereisis is a technique for treating symptomatic flexible flatfeet by means of inserting an implant or stent into the sinus tarsi. The goals are to reduce pain, deformity and instability of the foot. However, there are recognised complications associated with this technique which include malposition of th... | 25,220,881 | [
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Involvement of glutamatergic and GABAergic transmission in MK-801-increased gamma band oscillation power in rat cortical electroencephalograms. | Hypofunction of the N-methyl-D-aspartic acid receptor (NMDAr) has been considered to play a crucial role in the pathophysiology of schizophrenia. In rodent electroencephalogram (EEG) studies, non-competitive NMDAr antagonists have been reported to produce aberrant basal gamma band oscillation (GBO), as observed in schi... | 25,220,900 | [
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A stereological study of the mediodorsal thalamic nucleus in Down syndrome. | The total number of neurons and glial cells in the mediodorsal thalamic (MDT) nucleus of four aged females with Down syndrome (DS; mean age 69years) was estimated and compared to six age- and sex-matched controls. The MDT nucleus was delineated on coronal sections, and cell numbers (large and small neurons, oligodendro... | 25,220,902 | [
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Development and psychometric testing of the Clinical Learning Environment, Supervision and Nurse Teacher evaluation scale (CLES+T): the Spanish version. | The Clinical Learning Environment, Supervision and Nurse Teacher scale is a reliable and valid instrument to evaluate the quality of the clinical learning process in international nursing education contexts. This paper reports the development and psychometric testing of the Spanish version of the Clinical Learning Envi... | 25,220,932 | [
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Graphene supports in vitro proliferation and osteogenic differentiation of goat adult mesenchymal stem cells: potential for bone tissue engineering. | Current treatments for bone loss injuries involve autologous and allogenic bone grafts, metal alloys and ceramics. Although these therapies have proved useful, they suffer from inherent challenges, and hence, an adequate bone replacement therapy has not yet been found. We hypothesize that graphene may be a useful nanos... | 25,220,951 | [
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Sexuality, Self-Esteem and Partnership Quality in Infertile Women and Men. | <bIntroduction:</b Infertile couples often report quality-of-life impairments, especially in terms of sexuality, self-esteem and partnership quality. So far, there have been no systematic studies of the sex lives and behaviour of infertile women and men before and after the emergence of their mutual desire for a child.... | 25,221,344 | [
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Does Intellectual Property Restrict Output? An Analysis of Pharmaceutical Markets. | Standard normative analysis of intellectual property focuses on the balance between incentives for research and the static welfare costs of reduced price-competition from monopoly. However, static welfare loss from patents is not universal. While patents restrict price competition, they may also provide static welfare ... | 25,221,349 | [
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Happy Marriage, Happy Life? Marital Quality and Subjective Well-Being in Later Life. | The authors examined associations between marital quality and both general life satisfaction and experienced (momentary) well-being among older husbands and wives, the relative importance of own versus spouse's marital appraisals for well-being, and the extent to which the association between own marital appraisals and... | 25,221,351 | [
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Symbolic Interaction and Applied Social Research: A FOCUS ON TRANSLATIONAL SCIENCE RESEARCH<sup>1.</sup> | In symbolic interaction, a traditional yet unfortunate and unnecessary distinction has been made between basic and applied research. The argument has been made that basic research is intended to generate new knowledge, whereas applied research is intended to apply knowledge to the solution of practical (social and orga... | 25,221,375 | [
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Two polymorphisms in the Fractalkine receptor CX3CR1 gene influence the development of atherosclerosis: a meta-analysis. | The associations between the Fractalkine receptor (CX3CR1) gene T280M (rs3732378) and V249I (rs3732379) polymorphisms and atherosclerosis (AS) risk are conflicting. The aim of this meta-analysis was undertaken to assess their associations. PubMed, Embase, Web of Science, Medline, Cochrane database, and CNKI were search... | 25,221,380 | [
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Varied presentations of moyamoya disease in a tertiary care hospital of north-east India. | Moyamoya disease is a chronic progressive cerebrovascular disorder, characterized by stenosis or occlusion of bilateral internal carotid arteries (ICAs), anterior cerebral arteries (ACAs) and middle cerebral arteries (MCAs), accompanied by a collateral network of vessels formed at the base of the brain. Ischemia and in... | 25,221,403 | [
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Neuropsychiatric profiles in patients with Alzheimer's disease and vascular dementia. | The aim of the following study is to compare the behavioral and psychological symptoms of dementia (BPSD) in patients of Alzheimer disease (AD) and vascular dementia (VaD). We used National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association criteria fo... | 25,221,405 | [
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Evaluation of circulating miRNAs in wet age-related macular degeneration. | In the present study, we aimed to investigate the changes in plasma miRNA in patients with wet age-related macular degeneration. The expression profiles of 384 miRNAs in plasma from 33 patients (22 male, 11 female) who were diagnosed with wet age-related macular degeneration with fundus examination, fundus fluorescein ... | 25,221,421 | [
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Knowledge, attitudes and practices of Ugandan men regarding prostate cancer. | The incidence of prostate cancer in Uganda is one of the highest recorded in Africa. Prostate cancer is the most common cancer among men in Uganda. This study assessed the current knowledge, attitudes and practices of adult Ugandan men regarding prostate cancer. We conducted a descriptive cross-sectional study using in... | 25,221,428 | [
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Adolescent but not adult-born neurons are critical for susceptibility to chronic social defeat. | Recent evidence implicates adult hippocampal neurogenesis in regulating behavioral and physiologic responses to stress. Hippocampal neurogenesis occurs across the lifespan, however the rate of cell birth is up to 300% higher in adolescent mice compared to adults. Adolescence is a sensitive period in development where e... | 25,221,485 | [
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A mouse model of non-motor symptoms in Parkinson's disease: focus on pharmacological interventions targeting affective dysfunctions. | Non-motor symptoms, including psychiatric disorders, are increasingly recognized as a major challenge in the treatment of Parkinson's disease (PD). These ailments, which often appear in the early stage of the disease, affect a large number of patients and are only partly resolved by conventional antiparkinsonian medica... | 25,221,486 | [
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Overexpression of DeltaFosB in nucleus accumbens mimics the protective addiction phenotype, but not the protective depression phenotype of environmental enrichment. | Environmental enrichment produces protective addiction and depression phenotypes in rats. ΔFosB is a transcription factor that regulates reward in the brain and is induced by psychological stress as well as drugs of abuse. However, the role played by ΔFosB in the protective phenotypes of environmental enrichment has no... | 25,221,490 | [
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Spatial task context makes short-latency reaches prone to induced Roelofs illusion. | The perceptual localization of an object is often more prone to illusions than an immediate visuomotor action towards that object. The induced Roelofs effect (IRE) probes the illusory influence of task-irrelevant visual contextual stimuli on the processing of task-relevant visuospatial instructions during movement prep... | 25,221,500 | [
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Movement-related cortical potentials in paraplegic patients: abnormal patterns and considerations for BCI-rehabilitation. | Non-invasive EEG-based Brain-Computer Interfaces (BCI) can be promising for the motor neuro-rehabilitation of paraplegic patients. However, this shall require detailed knowledge of the abnormalities in the EEG signatures of paraplegic patients. The association of abnormalities in different subgroups of patients and the... | 25,221,505 | [
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Efflux pump proteins in antifungal resistance. | It is now well-known that the enhanced expression of ATP binding cassette (ABC) and major facilitator superfamily (MFS) proteins contribute to the development of tolerance to antifungals in yeasts. For example, the azole resistant clinical isolates of the opportunistic human fungal pathogen Candida albicans show an ove... | 25,221,515 | [
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Rapid heartbeat, but dry palms: reactions of heart rate and skin conductance levels to social rejection. | Social rejection elicits negative mood, emotional distress, and neural activity in networks that are associated with physical pain. However, studies assessing physiological reactions to social rejection are rare and results of these studies were found to be ambiguous. Therefore, the present study aimed to examine and s... | 25,221,535 | [
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Perceptual and contextual awareness: methodological considerations in the search for the neural correlates of consciousness. | In the last decades, the neural correlates of consciousness (NCCs) have been explored using both invasive and non-invasive recordings by comparing the brain activity elicited by seen versus unseen visual stimuli (i.e., the contrastive analysis). Here, we review a selection of these studies and discuss a set of consider... | 25,221,537 | [
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Cell-free nucleic acids as noninvasive biomarkers for colorectal cancer detection. | Cell-free nucleic acids (CFNA) have been reported by several authors in blood, stool, and urine of patients with colorectal cancer (CRC). These genetic biomarkers can be an indication of neoplastic colorectal epithelial cells, and can thus potentially be used as noninvasive tests for the detection of the disease in CRC... | 25,221,563 | [
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Morphological changes of gonadotropin-releasing hormone neurons in the rat preoptic area across puberty. | Gonadotropin-releasing hormone (GnRH) neurons in the preoptic area may undergo morphological changes during the pubertal period when their activities are upregulated. To clarify the regulatory mechanism of puberty onset, this study aimed to investigate the morphological changes of GnRH neurons in the preoptic area of G... | 25,221,583 | [
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Green tea polyphenols protect spinal cord neurons against hydrogen peroxide-induced oxidative stress. | Green tea polyphenols are strong antioxidants and can reduce free radical damage. To investigate their neuroprotective potential, we induced oxidative damage in spinal cord neurons using hydrogen peroxide, and applied different concentrations (50-200 μg/mL) of green tea polyphenol to the cell medium for 24 hours. Measu... | 25,221,595 | [
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Narrow-Band Ultraviolet B versus Oral Minocycline in Treatment of Unstable Vitiligo: A Prospective Comparative Trial. | Background. We have compared NB-UVB and oral minocycline in stabilizing vitiligo for the first time. Subjects and Methods. 42 patients were divided equally into two groups: the NB-UVB and minocycline groups. Phototherapy was administered twice a week on nonconsecutive days. In the minocycline group, patients were advis... | 25,221,600 | [
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MicroRNAs and Polycystic Kidney Disease. | Polycystic kidney disease (PKD), the most common genetic cause of chronic renal failure, is characterized by the presence of numerous fluid-filled cysts in renal parenchyma. Despite recent progress, no FDA-approved therapy is available to retard cyst growth. Here, we review current evidence implicating two groups of mi... | 25,221,607 | [
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THE HEALTH OF OLDER WOMEN AFTER HIGH PARITY IN TAFT, IRAN. | High parity has been hypothesised to lead to a shorter and less healthy life. Using the 2007 Taft Ageing Health and Fertility Survey consisting of 696 women aged 50-79, this paper examines the extent to which women's health in middle and older ages is affected by their childbearing histories. The results show that high... | 25,221,610 | [
0.1355253,
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0.1060076,
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0.1306416,
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0.3451656,
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0.1580951,
0.6795689,
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-0.... |
Optimization of Aqueous Biphasic Tumor Spheroid Microtechnology for Anti-Cancer Drug Testing in 3D Culture. | Tumor spheroids are three-dimensional clusters of cancer cells that exhibit characteristics of poorly perfused tumors and hence present a relevant model for testing the efficacy of anti-cancer compounds. The use of spheroids for drug screening is hindered by technological complexities for high throughput generation of ... | 25,221,631 | [
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... |
Novel antiproliferative chimeric compounds with marked histone deacetylase inhibitory activity. | Given our interest in finding potential antitumor agents and in view of the multifactorial mechanistic nature of cancer, in the present work, taking advantage of the multifunctional ligands approach, new chimeric molecules were designed and synthesized by combining in single chemical entities structural features of SAH... | 25,221,651 | [
-0.1932566,
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0.3220713,
0.3618253,
0.263165,
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... |
Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction. | The YAP-TEAD protein-protein interaction (PPI) mediates the oncogenic function of YAP, and inhibitors of this PPI have potential usage in treatment of YAP-involved cancers. Here we report the design and synthesis of potent cyclic peptide inhibitors of the YAP-TEAD interaction. A truncation study of YAP interface 3 pept... | 25,221,655 | [
-0.210631,
0.1255042,
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Exploration of 3-Aminoazetidines as Triple Reuptake Inhibitors by Bioisosteric Modification of 3-α-Oxyazetidine. | For a development of broad spectrum antidepressant 3-aminoazetidine derivatives, two series of compounds were explored by bioisosteric modification of 3-α-oxyazetidine. We synthesized 166 novel 3-aminoazetidine derivatives in series A and B, starting from Boc-protected 3-azetidinone (3) and Boc-protected 3-azetidinal (... | 25,221,656 | [
-0.2231385,
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0.255719,
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0.1283543,
0.06445517,
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Intracranial complication of rhinosinusitis from actinomycosis of the paranasal sinuses: a rare case of abducens nerve palsy. | Sinonasal actinomycosis should be suspected when a patient with chronic sinusitis does not respond to medical therapy or has a history of facial trauma, dental disease, cancer, immunodeficiency, long-term steroid therapy, diabetes, or malnutrition. Radiological evaluation with computed tomography and magnetic resonance... | 25,221,679 | [
-0.3740619,
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0.1124126,
0.1386068... |
Giant popliteal artery aneurysm: case report and review of the literature. | Popliteal artery aneurysms (PAAs) are rare in general population but represent the second most common peripheral arterial aneurysms following those located in the aortoiliac segment. They usually affect men over 60 years old with established cardiovascular disease caused by atherosclerosis. Other more unusual condition... | 25,221,686 | [
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0.1294481,
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0.1921133,
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... |
Congenital heart diseases in adults: a review of echocardiogram records in enugu, South-East Nigeria. | Congenital abnormalities of the heart and cardiovascular system are reported in almost 1% of live births, and about half of these children need medical or surgical help in infancy. In the first decade, a further 25% require surgery to maintain or improve their life. Only 10% survive to adolescence without treatment. Of... | 25,221,697 | [
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0.2778634,
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0.4440809,
-0.36285... |
Immunization dropout rates in ihe, awgu local government area, enugu state, South East Nigeria: a 1 year review. | Immunization against childhood diseases is one of the most important ways of preventing childhood morbidity and mortality. The objective of this study is to review the dropout rates of immunization of children in a health center using a single dose of diphtheria-pertussis-tetanus (DPT1) and three doses of diphtheria-pe... | 25,221,721 | [
-0.1425391,
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0.1812647,
0.2151138,
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0.01702744,
0.350518,
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Drug Utilization Study in Ophthalmology Out-patient Department of a Medical College in India. | Drug utilization studies provide a pharmacoeconomic basis for making evidence-based health-care decisions. In ophthalmology practice, rational prescribing plays a crucial role in reducing the ocular disease burden. The aim of the study was to investigate the drug utilization pattern in ophthalmology out-patient departm... | 25,221,726 | [
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0.3924249,
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0.04101015,
0.04856912,
0.1742799,
0.02431623,
0.... |
Provider Attitudes toward Discussing Fertility Intentions with HIV-Infected Women and Serodiscordant Couples in the USA. | Recent research suggests that pregnancy is a potentially safe option for couples with at least one HIV-infected adult. Data regarding provider discussion of fertility intentions with women living with HIV (WLWH) or in serodiscordant relationships is limited. We conducted a cross-sectional self-administered survey of he... | 25,221,730 | [
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0.3720765,
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0.01348178,
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-0.007562506,
0.003640958,
0.3858171,
-0.246230... |
The successful detection of postpartum unruptured vaginal pseudoaneurysm using ultrasonography: a case report. | We report the first case of the successful detection of postpartum unruptured vaginal pseudoaneurysm using power- and pulsed-Doppler ultrasonography after delivery. A 38-year-old primiparous Japanese woman had a vaginal laceration with pulsatile bleeding after delivering by vacuum extraction. Transvaginal ultrasonograp... | 25,221,737 | [
-0.4066097,
0.08944418,
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0.2813897,
0.1175338,
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0.08086217,
0.07893138,
-0.2143279,
... |
Arsenic and Chronic Kidney Disease: A Systematic Review. | In epidemiologic studies, high arsenic exposure has been associated with adverse kidney disease outcomes. We performed a systematic review of the epidemiologic evidence of the association between arsenic and various kidney disease outcomes. The search period was January 1966 through January 2014. Twenty-five papers (co... | 25,221,743 | [
-0.08576261,
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0.03567943,
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0.08760145,
0.3629138,
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0.... |
Dimethylarginine dimethylaminohydrolase (DDAH) overexpression attenuates agricultural organic dust extract-induced inflammation. | Modern, industrialized farming practices have lead to working conditions that include high levels of airborne dust. Agricultural workers inhale these complex organic dusts on a daily basis, leading to airway inflammation and higher risk for developing chronic obstructive pulmonary disease. The mechanisms regulating the... | 25,221,746 | [
-0.2320926,
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0.1533782,
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0.397532,
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0.3787735,
0.1515237,
0.08246566,
-0.08129179,
0.6604022,
-0.2508326,... |
Long-term results of pleurodesis in malignant pleural effusions: Doxycycline vs Bleomycin. | The aim of this study was to compare the response of doxycycline and bleomycin in pleurodesis of malignant pleural effusions. The radiologic and clinical responses of doxycycline and bleomycin in pleurodesis of malignant pleural effusions were compared in this randomized clinical trial. Forty-two patients were randomiz... | 25,221,752 | [
0.162119,
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0.1139336,
0.05310954,
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0.1407462,
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0.1180804,
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0.06333674,
0.0376884,
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... |
The effect of interprofessional education on interprofessional performance and diabetes care knowledge of health care teams at the level one of health service providing. | The increase in life expectancy and changes in lifestyle have led to prevalence of non-communicable diseases including diabetes whose treatment and care requires effective teamwork. This study was conducted to examine the effect of inter-professional education on performance and diabetes care knowledge of health care t... | 25,221,756 | [
-0.1901677,
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0.07983648,
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0.008082892,
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0.1303075,
0.03610387,
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0.1163591,
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0.07328998,
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0.2257953,
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0.4178897,
0.2522494... |
Is there a place for open intramedullary nailing in femoral shaft fractures? | Femoral shaft fractures are among the most common fractures following high trauma injuries. Different kinds of treatment have been suggested for these injuries. The aim of this study was to compare the results femoral fractures treated by mini open and close intramedullary nailing (IMN) technique. A total of 48 adult p... | 25,221,760 | [
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0.2731393,
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0.1823169,
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0.1425595,
0.469694,
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0.08485131,
0... |
Solitary giant neurofibroma of thigh. | Neurofibromas are rare, benign, nerve sheath tumors in the peripheral nervous system. The solitary type is found in those who do not have neurofibromatosis. Solitary neurofibromas are too rare in the giant type. We report a rare case of a solitary giant neurofibroma of the anterior right thigh. The diagnostic criteria,... | 25,221,761 | [
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0.1191832,
0.08052332,
-0.3286931,
0.06631064,
0.04626868,
-0.171... |
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