title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Management of pediatric craniocervical arterial dissections. | Craniocervical arterial dissections (CCADs) represent a preventable cause of acute ischemic stroke (AIS). Our objective was to describe clinical presentation, imaging features, treatment strategies, and report clinical and imaging outcomes of CCADs at a large pediatric tertiary referral center. Electronic medical recor... | 25,227,167 | [
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A case report of a pediatric traumatic aneurysm with arteriovenous (A-V) fistula CASE-BASED UPDATE. | Traumatic intracranial aneurysms (TICAs) are rare, representing less than 5 % of all intracranial aneurysms. Most TICAs are located within the anterior circulation, and less than 10 % of TICAs occur in the posterior circulation. Histopathologically, most TICAs are false aneurysms and have a high risk of rupture or re-b... | 25,227,169 | [
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Roles of glycosaminoglycans and glycanmimetics in tumor progression and metastasis. | Various tumor cells exhibit structural alterations in the sulfated modifications to glycosaminoglycans (GAGs). The altered expression of chondroitin sulfate (CS) and heparan sulfate (HS) on the surfaces of tumor cells is known to play a key role in malignant transformation and tumor metastasis. The receptor molecule fo... | 25,227,175 | [
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Pressure monitoring during lipofilling procedures. | Grafting of autologous lipoaspirate for various clinical applications has become a common procedure in clinical practice. With an estimated mortality rate of 10-15 percent, fat embolism is among the most severe complications to be expected after lipofilling therapies. The aim of this study was to determine the level of... | 25,227,189 | [
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Effect of radiographic contrast media (Iodixanol, Iopromide) on hemolysis. | Radiographic contrast media can lead to drastic changes of the morphology of erythrocytes. The change of the erythrocyte morphology is associated with a decreased deformability possibly resulting from distinctions in the loss of constituents of the membrane cytoskeleton. However, it is unclear whether there is an intra... | 25,227,190 | [
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Genetic engineering of mesenchymal stem cells by non-viral gene delivery. | Mesenchymal stem cells (MSCs) are an ideal cell source for tissue engineering and regenerative medicine as they possess self-renewal properties and multilineage differentiation potential. They can be isolated from various tissues and expanded easily through normal cell culture techniques. Genetic modifications of MSCs ... | 25,227,201 | [
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Toward the harmonization of result presentation for the eosin-5'-maleimide binding test in the diagnosis of hereditary spherocytosis. | The eosin-5'-maleimide (EMA) Binding test measures reduced mean channel fluorescence (MCF) reading of EMA-labeled red cells (EMA-RBCs) from patients with hereditary spherocytosis (HS). Reporting test results can be either in the actual MCF reading or as a ratio by normalization of the test MCF result to the mean MCF va... | 25,227,211 | [
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Treatment outcome of mineral trioxide aggregate or calcium hydroxide direct pulp capping: long-term results. | This controlled, historic cohort study project continues a previously reported trial aiming to assess treatment outcome of direct pulp capping with mineral trioxide aggregate (MTA) versus calcium hydroxide (CH). Potential prognostic factors were re-evaluated on the basis of a larger sample size and longer follow-up per... | 25,227,216 | [
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Serotonergic correlation with anger and aggressive behavior in acute stroke patients: an intensity dependence of auditory evoked potentials (IDAP) study. | Anger and aggressive behavior (AB) are two of the main post-stroke behavioral manifestations, which could imply both an anger trait (TA) or a state condition of anger (SA). Serotonergic system is thought to play an inhibitory control on aggressive impulse. Nevertheless, whether 5HT has the same role in TA and in SA, is... | 25,227,246 | [
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Impact of Percutaneous Interventions for Pulmonary Artery Stenosis in Alagille Syndrome. | The study aims to examine acute and midterm outcomes after percutaneous interventions for treatment of pulmonary artery stenosis (PAS) in patients with Alagille Syndrome (ALGS). PAS affects up to two thirds of ALGS patients. Responsiveness to transcatheter therapies may differ from other causes of PAS. To date, there h... | 25,227,273 | [
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In vivo assessment of arterial stiffness in the isoflurane anesthetized spontaneously hypertensive rat. | Rodent models are increasingly used to study the development and progression of arterial stiffness. Both the non-invasive Doppler derived Pulse Wave Velocity (PWV) and the invasively determined arterial elastance index (EaI) have been used to assess arterial stiffness in rats and mice, but the need for anesthetic agent... | 25,227,282 | [
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A review of the epidemiology of inflammatory bowel disease with a focus on diet, infections and antibiotic exposure. | Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic debilitating diseases that occur in populations around the world. The underlying etiology is thought to be multifactorial. There is a well-defined genetic contribution to the diseases, but this does not fully expla... | 25,227,291 | [
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Antibiotics, probiotics and prebiotics in IBD. | The dysbiosis theory of inflammatory bowel disease (IBD) posits that there is an alteration in the gut microbiome as an important underpinning of disease etiology. It stands to reason then, that administering agents that could impact on the balance of microbes on the gut could be impactful on the course of IBD. Herein ... | 25,227,297 | [
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Subthalamic nucleus-deep brain stimulation for early motor complications in Parkinson's disease-the EARLYSTIM trial: early is not always better. | Subthalamic nucleus deep brain stimulation (STN-DBS) has revolutionized the management of disabling motor complications in Parkinson's disease. The EARLYSTIM trial applied this treatment to patients who had been experiencing motor complications for less than three years. STN-DBS significantly improved all primary and s... | 25,227,325 | [
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Government action could have prevented sepsis deaths. | MPs have criticised the government for a lack of urgency in preventing deaths from sepsis. | 25,227,345 | [
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Subcutaneous injection technique: an evidence-based approach. | Injections are routinely administered by nurses in acute care settings and in the community. Nurses require a thorough understanding of anatomy and physiology, pharmacological principles and equipment, and potential risks to the patient of injections. Nurses should also take an active approach to patient assessment bef... | 25,227,387 | [
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Renal agenesis in Kallmann syndrome: a network approach. | Kallmann syndrome (KS) is defined by the combination of isolated hypogonadotrophic hypogonadism (IHH) and anosmia, with renal agenesis occurring in 30% of KS cases with KAL1 gene mutations. Unlike other KS-related disorders, renal agenesis cannot be directly associated with mutations in the KAL1 gene. We hypothesized t... | 25,227,403 | [
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Oxidant-induced damage to equine erythrocytes from exposure to Pistacia atlantica, Pistacia terebinthus, and Pistacia chinensis. | Two horses were referred for methemoglobinemia and hemolytic anemia following 5 acute deaths in their herd from an unidentified toxin source. Horses have a greater risk than other mammalian species of developing methemoglobinemia and hemolytic anemia following ingestion of oxidizing toxins, due to deficiencies in the m... | 25,227,420 | [
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Virus-mediated compartmentalization of the host translational machinery. | Viruses require the host translational apparatus to synthesize viral proteins. Host stress response mechanisms that suppress translation, therefore, represent a significant obstacle that viruses must overcome. Here, we report a strategy whereby the mammalian orthoreoviruses compartmentalize the translational machinery ... | 25,227,463 | [
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The role of particle-to-cell interactions in dictating nanoparticle aided magnetophoretic separation of microalgal cells. | Successful application of a magnetophoretic separation technique for harvesting biological cells often relies on the need to tag the cells with magnetic nanoparticles. This study investigates the underlying principle behind the attachment of iron oxide nanoparticles (IONPs) onto microalgal cells, Chlorella sp. and Nann... | 25,227,473 | [
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The capacity of neural crest-derived stem cells for ocular repair. | Whether it is due to a particular epigenetic signature, or some other component of an embryonic differentiation program, accumulating evidence indicates that the origins of a stem cell has a profound impact on the potential of a tissue to regenerate and repair. Here, we focus on Müller glia, long considered the stem ce... | 25,227,475 | [
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Mutations in MFSD8, encoding a lysosomal membrane protein, are associated with nonsyndromic autosomal recessive macular dystrophy. | This study aimed to identify the genetic defects in 2 families with autosomal recessive macular dystrophy with central cone involvement. Case series. Two families and a cohort of 244 individuals with various inherited maculopathies and cone disorders. Genome-wide linkage analysis and exome sequencing were performed in ... | 25,227,500 | [
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NMES with rTMS for moderate to severe dysfunction after stroke. | Motor dysfunction after stroke might be improved by neuromuscular electrical stimulation (NMES) combined with 1 Hz repetitive transcranial magnetic stimulation (rTMS) in patients with moderate and severe motor dysfunction. This preliminary study tested the effect of this treatment combination. Fifteen patients (60.5 ± ... | 25,227,537 | [
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Immunocytochemical markers of neuronal maturation in human diagnostic neuropathology. | Histological descriptions of morphogenesis in human fetal brain and in malformations and tumours can now be supplemented by the timing and sequence of the maturation of individual neurons. In human neuropathology, this is principally achieved by immunocytochemical reactivities used as maturational markers of neuronal p... | 25,227,552 | [
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Performance of perfusion-weighted Fourier decomposition MRI for detection of chronic pulmonary emboli. | To evaluate the test performance of perfusion-weighted Fourier-decomposition (pw-FD) magnetic resonance imaging (MRI) in comparison to dynamic contrast-enhanced (DCE)-MRI as a reference standard in patients with known or suspected chronic pulmonary embolism (PE). In 64 patients, chronic PE was ruled out or confirmed by... | 25,227,559 | [
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Volatilize-controlled oriented growth of the single-crystal layer for organic field-effect transistors. | We demonstrate a solution method of volatilize-controlled oriented growth (VOG) to fabricate aligned single crystals of 6,13-bis(triisopropylsilylethynyl) pentacene (TIPS pentacene) on a Si/SiO2 substrate. Through controlling the evaporation rate of the solvent, large-area-aligned single-crystal layers can be achieved ... | 25,227,560 | [
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The neural crest: a versatile organ system. | The neural crest is the name given to the strip of cells at the junction between neural and epidermal ectoderm in neurula-stage vertebrate embryos, which is later brought to the dorsal neural tube as the neural folds elevate. The neural crest is a heterogeneous and multipotent progenitor cell population whose cells und... | 25,227,568 | [
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The J-curve in arterial hypertension: fact or fallacy? | It is known that a large proportion of patients with arterial hypertension are undertreated. This may result in an increase of the incidence of cardiovascular events. On the other hand, aggressive reduction of blood pressure may increase cardiovascular events (J-curve phenomenon) in certain populations. This phenomenon... | 25,227,573 | [
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0.08288702,
-0.04090948... |
Assessment of changing patterns of Le fort fracture lines using computed tomography scan: an observational study. | To assess the changing mid-face fracture patterns using a computed tomography scan. Fifty patients with mid-face trauma requiring open reduction and fixation were studied using 1.6 mm axial, sagittal, coronal and 3D images. Images were evaluated clinically, intra-operatively and finally were compared with standard Le F... | 25,227,590 | [
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Protective effect of the long pentraxin PTX3 against histone-mediated endothelial cell cytotoxicity in sepsis. | Pentraxin 3 (PTX3), a member of the long pentraxin subfamily within the family of pentraxins, is a soluble pattern recognition molecule that functions in the innate immune system. Innate immunity affords the infected host protection against sepsis, a potentially life-threatening inflammatory response to infection. Extr... | 25,227,610 | [
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Postresuscitation debriefing in the pediatric emergency department: a national needs assessment. | The objectives of this study were to assess current postresuscitation debriefing (PRD) practices in Canadian pediatric emergency departments (EDs) and identify areas for improvement. A national needs assessment survey was conducted to collect information on current PRD practices and perspectives on debriefing practice ... | 25,227,647 | [
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CLIC1 overexpression is associated with poor prognosis in gallbladder cancer. | The chloride intracellular channel 1 (CLIC1) gene family is a recently identified class of Cl channel proteins. Although CLIC1 involvement is well established in some cancers such as gastric cancer and colon cancer, its expression pattern in gallbladder cancer (GBC) remains unknown. The aim of our study was to investig... | 25,227,665 | [
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Pooling knowledge and improving safety for contracted works at a large industrial park. | At a large chemical park maintenance is contracted by the major companies operating the plants to many small firms. The cultural and psychological isolation of contractor workers was recognized a root cause of severe accidents in the recent years. That problem is common in chemical industry. The knowledge sharing has b... | 25,227,671 | [
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Targeting survival pathways to create infarct-spanning bridges of human embryonic stem cell-derived cardiomyocytes. | Generating myocyte grafts that bridge across infarcts could maximize their functional impact and best utilize small numbers of stem cells. To date, however, graft survival within acute infarcts has not been feasible. To enhance intrainfarct graft viability, human embryonic stem cell-derived cardiomyocytes (hESC-CMs) we... | 25,227,700 | [
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In situ single molecule imaging of cell membranes: linking basic nanotechniques to cell biology, immunology and medicine. | The cell membrane, which consists of a viscous phospholipid bilayer, different kinds of proteins and various nano/micrometer-sized domains, plays a very important role in ensuring the stability of the intracellular environment and the order of cellular signal transductions. Exploring the precise cell membrane structure... | 25,227,707 | [
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Comorbidity between post-traumatic stress disorder and borderline personality disorder: a review. | Traditionally, the presence of post-traumatic stress disorder (PTSD) in subjects diagnosed with borderline personality disorder (BPD) has been the object of scant empirical research. The clarification of issues related to the different areas of study for this comorbidity is not only significant from a theoretical point... | 25,227,722 | [
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Autophagy-related gene Atg5 is essential for astrocyte differentiation in the developing mouse cortex. | Astrocyte differentiation is essential for late embryonic brain development, and autophagy is active during this process. However, it is unknown whether and how autophagy regulates astrocyte differentiation. Here, we show that Atg5, which is necessary for autophagosome formation, regulates astrocyte differentiation. At... | 25,227,738 | [
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Effects of miglustat treatment in a patient affected by an atypical form of Tangier disease. | Tangier disease (TD) is a rare autosomal recessive disorder, resulting from mutations in the ATP binding cassette transporter (ABCA1) gene. The deficiency of ABCA1 protein impairs high density lipoprotein (HDL) synthesis and cholesterol esters trafficking. A 58 year-old female, presenting with complex clinical signs (s... | 25,227,739 | [
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Targeting VEGF/VEGFR in the treatment of psoriasis. | Psoriasis is a common chronic skin disorder characterized by cutaneous inflammation and keratinocyte hyperproliferation. In the past decade, a number of novel effective biological agents have been developed to treat moderate-to-severe psoriasis. However, these drugs have potential serious side effects, particularly the... | 25,227,750 | [
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Tubular reabsorption of high, middle and low molecular weight proteins according to the tubulo-interstitial damage marker N-acetyl-β-D-glucosaminidase in glomerulonephritis. | Proteinuria, the hallmark of glomerular diseases, is an independent predictor of end-stage renal disease (ESRD) progression. Proteinuria is a mixture of proteins of different molecular weight (MW) dependent on alterations of glomerular filtration barrier (GFB) and reabsorption impairment by proximal tubular epithelial ... | 25,227,764 | [
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Evaluating the social determinants of teenage pregnancy: a temporal analysis using a UK obstetric database from 1950 to 2010. | Teenage pregnancy is a known social problem which has been previously described using a number of deprivation measures. This study aimed to explore the temporal patterns of teenage pregnancy in Aberdeen, Scotland and to assess the discriminating ability of three measures of socioeconomic status. This was a population-b... | 25,227,769 | [
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The Social Gap Index and the prevalence of osteoarthritis in the community: a cross-sectional multilevel study in Mexico. | Multilevel studies have gained importance for highlighting social inequalities in health. These associations have been reported previously in diseases such as arthritis and chronic pain. We conducted a cross-sectional study using multilevel analysis to identify individual and contextual factors associated with the vari... | 25,227,770 | [
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DNA fragmentation, caspase 3 and prostate-specific antigen genes expression induced by arsenic, cadmium, and chromium on nontumorigenic human prostate cells. | Prostate cancer is one of the most common cancers and the second cause of cancer-related deaths among men. Metals are recognized as chemical carcinogens where chronic exposures to such metals are implicated in the development of cancer, including prostate cancer. This in vitro study demonstrates the relative death sens... | 25,227,780 | [
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Score based risk assessment of lung cancer and its evaluation for Bangladeshi people. | The problem of cancer, especially lung cancer, is very acute in Bangladesh. The present study was conducted to evaluate the risk of lung cancer among Bangladeshi people based on hereditary, socio-economic and demographic factors. This study was carried out in 208 people (patients-104, controls-104) from January 2012 to... | 25,227,785 | [
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Fatty acid synthesis pathway genetic variants and clinical outcome of non-small cell lung cancer patients after surgery. | Over-expression of de novo lipogenesis (DNL) genes is associated with the prognosis of various types of cancers. However, the effects of single nucleotide polymorphisms (SNPs) in these genes on recurrence and survival of non-small cell lung cancer (NSCLC) patients after surgery are still unknown. In this study, a total... | 25,227,797 | [
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Second-line capecitabine and oxaliplatin combination for gemcitabine-resistant advanced pancreatic cancer. | The role of second-line therapy in metastatic pancreatic cancer is not clear. In this study, we aimed to explore the second-line efficiency of capecitabine and oxaliplatin (XELOX) in patients with advanced pancreatic cancer who have received gemcitabine-based first-line therapy. We retrospectively evaluated 47 patients... | 25,227,800 | [
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Associations between the rs6010620 polymorphism in RTEL1 and risk of glioma: a meta-analysis of 20,711 participants. | Associations between the rs6010620 polymorphism in the regulator of telomere elongation helicase1 (RTEL1) gene and glioma have been widely reported but the results were not inconclusive. The aim of the current study was to investigate the association between the rs6010620 polymorphism in RTEL1 gene and risk of glioma b... | 25,227,808 | [
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Clinical study on carboplatin for treating pediatric patients with Wilms tumors. | This analysis was conducted to evaluate the efficacy and safety of carboplatin based chemotherapy in treating pediatric patients with Wilms tumors. Clinical studies evaluating the efficacy and safety of carboplatin based regimens on response and safety for pediatric patients with Wilms tumors were identified using a pr... | 25,227,828 | [
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A novel mutant of human papillomavirus type 18 E6E7 fusion gene and its transforming activity. | Persistent human papillomavirus (HPV) infection, especially with high-risk types such as HPV16 and HPV18, has been identified as the primary cause of cervical cancer. E6 and E7 are the major onco-proteins of high-risk HPVs, which are consistently expressed in HPV infected tissues but absent in normal tissues and repres... | 25,227,848 | [
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Comparison of 2-dimensional and 3-dimensional conformal treatment plans in gastric cancer radiotherapy. | Postoperative chemoradiotherapy is accepted as standard treatment for stage IB-IV, M0 gastric cancer. Radiotherapy (RT) planning of gastric cancer is important because of the low radiation tolerance of surrounding critical organs. The purpose of this study was to compare the dosimetric aspects of 2-dimensional (2D) and... | 25,227,849 | [
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Diagnostic values of serum levels of pepsinogens and gastrin-17 for screening gastritis and gastric cancer in a high risk area in northern Iran. | Gastric cancer (GC) is the second cause of cancer related death in the world. It may develop by progression from its precancerous condition, called gastric atrophy (GA) due to gastritis. The aim of this study was to evaluate the accuracy of serum levels of pepsinogens (Pg) and gastrin-17 (G17) as non-invasive methods t... | 25,227,854 | [
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Performance of 3D, navigator echo-gated, contrast-enhanced, magnetic resonance coronary vein imaging in patients undergoing CRT. | The aims of this study were to evaluate the ability of contrast-enhanced MRI to visualize the coronary veins with validation by the gold standard, X-ray venography, and to determine whether MRI can visualize the coronary vein branch used for left ventricular (LV) lead implantation. Nineteen (19) patients undergoing car... | 25,227,865 | [
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Catalytic imine-imine cross-coupling reactions. | We report here efficient catalytic imine-imine cross-coupling reactions based on an umpolung strategy; an imine bearing a 9-fluorenyl moiety on its nitrogen atom, which acted as a nucleophile, reacted with another imine to afford an imine-imine cross-coupling adduct in high yield. Furthermore, a chiral guanidine acted ... | 25,227,870 | [
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Experiences, utilisation and outcomes of maternity care in England among women from different socio-economic groups: findings from the 2010 National Maternity Survey. | The objective of this analysis was to explore the healthcare-seeking behaviours and experiences of maternity care among women from different socio-economic groups in order to improve understanding of why socially disadvantaged women have poorer maternal health outcomes in the UK. Secondary analysis of a national survey... | 25,227,878 | [
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[From fishing trip to the critical care unit : Successful resuscitation after a near drowning accident]. | In the context of the European Resuscitation Council (ERC) guidelines, modifications of the proposed treatment algorithm need to be performed in order to respond to different parameters. In this respect several factors interacting with cardiac arrest are essential and need to be included in the therapy. This case repor... | 25,227,882 | [
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0.0901589... |
Impact of lauric arginate application form on its antimicrobial activity on the surface of a model meat product. | This study evaluated the antimicrobial effect of N(α)-Lauroyl-L-arginine ethyl estermonohydrochloride (lauric arginate), sodium lactate, and sodium diacetate at various concentrations against Listeria innocua, Escherichia coli C600, and Lactobacillus curvatus (10(2) CFU/g) on "Lyoner style" sausage slices as a function... | 25,227,890 | [
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Exome sequencing identifies a novel frameshift mutation of MYO6 as the cause of autosomal dominant nonsyndromic hearing loss in a Chinese family. | Autosomal dominant types of nonsyndromic hearing loss (ADNSHL) are typically postlingual in onset and progressive. High genetic heterogeneity, late onset age, and possible confounding due to nongenetic factors hinder the timely molecular diagnoses for most patients. In this study, exome sequencing was applied to invest... | 25,227,905 | [
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Treatment intensification with maraviroc (CCR5 antagonist) leads to declines in CD16-expressing monocytes in cART-suppressed chronic HIV-infected subjects and is associated with improvements in neurocognitive test performance: implications for HIV-associated neurocognitive disease (HAND). | HIV-associated neurocognitive disorders (HAND) continues to be prevalent (30-50%) despite plasma HIV-RNA suppression with combination antiretroviral therapy (cART). There is no proven therapy for individuals on suppressive cART with HAND. We have shown that the degree of HIV reservoir burden (HIV DNA) in monocytes appe... | 25,227,930 | [
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One- to four-year follow-up of endobronchial lung volume reduction in alpha-1-antitrypsin deficiency patients: a case series. | Lung volume reduction surgery can improve lung function and working capacity in severe heterogeneous emphysema. Endobronchial lung volume reduction (ELVR) performed by one-way valves inserted via a flexible bronchoscope can result in a moderate but significant improvement in lung function and exercise tolerance, elimin... | 25,227,936 | [
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Occurrence and fate of triclosan and triclocarban in a subtropical river and its estuary. | The occurrence of triclosan (TCS) and triclocarban (TCC) in a subtropical river (Jiulong River) and its estuary was investigated for two years. TCS and TCC were ubiquitously detected in the Jiulong River and its estuary. The levels of TCS and TCC ranged from less than the method detection limit to 64 ng/L and from 0.05... | 25,227,953 | [
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Initial high-dose prednisolone combination therapy using COBRA and COBRA-light in early rheumatoid arthritis. | Treatment with initial high-dose prednisolone and a combination of methotrexate (MTX) and sulfasalazine (SSZ) according to the COBRA regimen (Dutch acronym for combinatietherapie bij reumatoide artritis, 'combination therapy for rheumatoid arthritis'), has repeatedly been demonstrated to be very effective in early rheu... | 25,227,967 | [
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Soluble CD44 and CD44v6 and prognosis in children with B-cell acute lymphoblastic leukemia. | CD44v6 is an isoform of CD44 that can be present in soluble form (sCD44v6). The aim of this study is to evaluate the presence of soluble CD44 (sCD44) and sCD44v6 in serum of children with B-cell precursor acute lymphoblastic leukemia (B-ALL) and their relationship with prognosis. sCD44v6 and sCD44 levels were measured ... | 25,227,983 | [
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Participants', caregivers', and professionals' experiences with a group-based rehabilitation program for Huntington's disease: a qualitative study. | Research suggests that rehabilitation is beneficial for persons with Huntington's disease (HD), but there is limited knowledge about participants' experiences with residential rehabilitation programs. We therefore did a study to explore patients', family caregivers', and health professionals' experiences with a group-b... | 25,227,988 | [
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Prediction of positive resection margins in patients with non-palpable breast cancer. | In patients undergoing breast conserving surgery for non-palpable breast cancer, obtaining tumour free resection margins is important to prevent reexcision and local recurrence. We developed a model to predict positive resection margins in patients undergoing breast conserving surgery for non-palpable invasive breast c... | 25,228,054 | [
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Pulmonary tuberculosis in Asian elephants (Elephas maximus): histologic lesions with correlation to local immune responses. | Although Mycobacterium tuberculosis infection is an important health concern for Asian elephants (Elephas maximus), no studies have evaluated the associated local immune responses or histologic lesions. In primates including humans, latent tuberculosis is distinguished by well-organized granulomas with TH1 cytokine exp... | 25,228,055 | [
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Life goal attainment in the adaptation process after acquired brain injury: the influence of self-efficacy and of flexibility and tenacity in goal pursuit. | To investigate attainment of important life goals and to examine whether self-efficacy, tenacity in goal pursuit and flexibility in goal adjustment contribute to adaptation by affecting levels of emotional distress and quality of life in patients with newly acquired brain injury. Data were collected from a prospective ... | 25,228,056 | [
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An exploration of decision aid effectiveness: the impact of promoting affective vs. deliberative processing on a health-related decision. | Decision aids (DAs) are non-directive communication tools that help patients make value-consistent health-care decisions. However, most DAs have been developed without an explicit theoretical framework, resulting in a lack of understanding of how DAs achieve outcomes. To investigate the effect of promoting affective vs... | 25,228,065 | [
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Oral delivery of ACE2/Ang-(1-7) bioencapsulated in plant cells protects against experimental uveitis and autoimmune uveoretinitis. | Hyperactivity of the renin-angiotensin system (RAS) resulting in elevated Angiotensin II (Ang II) contributes to all stages of inflammatory responses including ocular inflammation. The discovery of angiotensin-converting enzyme 2 (ACE2) has established a protective axis of RAS involving ACE2/Ang-(1-7)/Mas that countera... | 25,228,068 | [
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Estimating overannotation across prokaryotic genomes using BLAST+, UBLAST, LAST and BLAT. | As the number of genomes in public databases increases, it becomes more important to be able to quickly choose the best annotated genomes for further analyses in comparative genomics and evolution. A proxy to annotation quality is the estimation of overannotation by comparing annotated coding genes against the SwissPro... | 25,228,073 | [
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Validation of the Endopep-MS method for qualitative detection of active botulinum neurotoxins in human and chicken serum. | Botulinum neurotoxins (BoNTs) are highly toxic proteases produced by anaerobic bacteria. Traditionally, a mouse bioassay (MBA) has been used for detection of BoNTs, but for a long time, laboratories have worked with alternative methods for their detection. One of the most promising in vitro methods is a combination of ... | 25,228,079 | [
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Polymorphisms of progesterone receptor and ovarian cancer risk: a systemic review and meta-analysis. | Growing bodies of studies have investigated the associations between three progesterone receptor (PGR) polymorphisms, +331G/A, Alu insertion and Val660Leu, and susceptibility to ovarian cancer, but the results remain controversial and inconclusive. Thus, we conducted a meta-analysis to derive a more precise estimation ... | 25,228,088 | [
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Helical supramolecular aggregates of sugar-based perylene dyes: the effect of core-substituted groups. | Here we have shown that it is possible to modulate π-π stacking, hydrogen bonds and hydrophobic and hydrophilic interactions to further adjust the supramolecular helicity by simply changing the core-substituted group. These modulated supramolecular interactions provide a new pathway to the controlled production of heli... | 25,228,101 | [
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Non-invasive ménage à trois for the prediction of high-risk varices: stepwise algorithm using lok score, liver and spleen stiffness. | Liver stiffness (LS), spleen stiffness (SS) and serum markers have been proposed to non-invasively assess portal hypertension or oesophageal varices (EV) in cirrhotic patients. We aimed to evaluate the performance of a stepwise algorithm that combines Lok score with LS and SS for diagnosing high-risk EV (HREV) and to c... | 25,228,102 | [
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Strategies for diagnosing leg oedema in primary care: a qualitative study of GPs' approaches. | The symptom leg oedema represents a broad range of possible underlying aetiologies. The background of leg oedema is multifactorial and usually the GP is the first contact point for patients presenting with this symptom. GPs rely on patient history and physical examination as their main diagnostic tools. To identify GPs... | 25,228,104 | [
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Transforaminal lumbar interbody debridement and fusion for the treatment of infective spondylodiscitis in the lumbar spine. | To determine the safety and efficacy of using a single posterior approach with transforaminal lumbar interbody debridement and fusion (TLIDF) plus pedicle screws fixation in treating infective spondylodiscitis in the lumbar spine. Between January 2009 and June 2011, 28 patients with infective spondylodiscitis who under... | 25,228,109 | [
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Characteristics of robotically harvested hair follicles in Koreans. | Recently, an automated robotic hair restoration device was developed and is increasingly being used for hair restoration. We sought to analyze the hair follicles of Korean patients that were harvested by a hair restoration robotic device. Data were reviewed from a total of 22 patients who underwent robotic follicular u... | 25,228,110 | [
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Brain targeted intranasal delivery of tramadol: comparative study of microemulsion and nanoemulsion. | The present investigation was aimed to develop and compare microemulsion and nanoemulsion for brain targeted intranasal delivery of tramadol to achieve maximum therapeutic efficacy in treatment of episodic and emergency pain. Tramadol microemulsion (TME) and tramadol nanoemulsion (TNE) were developed and evaluated for ... | 25,228,122 | [
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What is single needle cannulation hemodialysis: is it adequate? | It is important to know the relative clearances obtained when using single-needle versus double-needle cannulation techniques. Twelve hemodialysis treatments were conducted using a machine that is capable of single-needle as well as double-needle cannulation. Single-needle and double-needle blood flow rates, as well as... | 25,228,136 | [
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Construction of an immobilised acetylcholinesterase column and its application in screening insecticidal constituents from Magnolia officinalis. | Application of a matrix-immobilised target enzyme for screening inhibitors is widely used in drug development, but there are few studies in insecticide discovery. In this paper, an economical and effective immobilised acetylcholinesterase (AChE) column was prepared using the sol-gel embedment method, which was further ... | 25,228,142 | [
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The role of neck dissection in squamous cell carcinoma of the head and neck. | Lymph node metastases in the neck are a major prognostic factor in patients with head and neck squamous cell carcinoma (HNSCC). Assessment and treatment of lymph nodes in the neck are of utmost importance. Inappropriate management of lymph node metastases can result in regional failure. Radical neck dissection has been... | 25,228,145 | [
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Dynamic nuclear polarization enhancement of protons and vanadium-51 in the presence of pH-dependent vanadyl radicals. | We report applications of dynamic nuclear polarization to enhance proton and vanadium-51 polarization of vanadyl sulfate samples doped with TOTAPOL under magic angle spinning conditions. The electron paramagnetic resonance response stemming from the paramagnetic (51)V species was monitored as a function of pH, which ca... | 25,228,149 | [
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Salvage Pelvic Lymph Node Dissection after Radical Prostatectomy for Biochemical and Lymph Node Recurrence. | Prostate cancer is the most common male malignancy. Radiation therapy and radical prostatectomy are the main curative treatment options for organ confined disease. Despite the good long-term oncologic outcomes, roughly 40% of patients undergoing surgery develop biochemical recurrence, manifested as a rising prostate-sp... | 25,228,162 | [
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Testicular resistive index determined by Doppler ultrasonography in men with spinal cord injury - a case series. | In this case series, the testicular resistive index was determined in men with spinal cord injury. In ten men participating in our fertility programme, the peak systolic and end-diastolic velocity of centripetal testicular arteries was measured in triplicates by Doppler ultrasonography to calculate the testicular resis... | 25,228,165 | [
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0.02935511,
0.03361838,
0.1915507... |
Chronic expanding haematoma in a cat. | A 5-year-old cat developed a recurrent haematoma in the right hindlimb after receiving an intramuscular injection. Cold packs and a compressive bandage were applied without success. The haematoma resolved initially but recurred twice within a week after conservative treatment. Contrast computed tomography was performed... | 25,228,168 | [
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0.0463954,
0.1555174,
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0.4719192,
-0.0234462... |
The status of neuroendocrine tumor imaging: from darkness to light? | Diagnostic imaging plays a pivotal role in the diagnosis, staging, treatment selection and follow-up for neuroendocrine tumors. The available diagnostic strategies are morphologic imaging, including computed tomography, magnetic resonance imaging (MRI) and ultrasound techniques, and molecular imaging, including scintig... | 25,228,173 | [
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0.1790107,
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... |
Using the theory of planned behavior to predict infant restraint use in Saudi Arabia. | To determine whether the theory of planned behavior (TPB) predicted intent of child restraint system (CRS) use among pregnant women in the Kingdom of Saudi Arabia (KSA). In this cross-sectional study conducted in Dallah Hospital, Riyadh, KSA during June-July 2013, 196 pregnant women completed surveys assessing their be... | 25,228,177 | [
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... |
Measuring adherence rate to quality indicators for diabetes care identified by primary health care in Bahrain. | To measure the quality of care for patients with diabetes mellitus at the outpatient clinics from 12 general practitioners clinics (GPC) and one diabetes care clinic (DCC). A cross-sectional study was conducted at the Al-Razi Health Center, Manama, Bahrain, and health records from January to December 2012 were reviewed... | 25,228,179 | [
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0.3546416,
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0.1... |
Descending necrotizing mediastinitis. | Descending necrotizing mediastinitis (DNM) is a rare but severe life threatening complication of oropharyngeal infections. We report a young lady who had severe pharyngitis complicated by anterior neck infection that descended to the mediastinum causing necrotizing mediastinitis. The course of her illness was complicat... | 25,228,187 | [
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0.3524213,
0.09178164,
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Extreme oral myiasis. | Extreme oral myiasis is a rare condition, mostly affecting bedridden patients whose oral health care measures are neglected. Single stage manual removal of the maggots along with the necrotic tissue, debridement, and suturing under general anesthesia is the most effective way to treat the condition. Preventive measures... | 25,228,190 | [
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Retrospective analysis of fetal anterior abdominal wall defects. | To analyze fetal abdominal defects diagnosed during the prenatal period in the perinatology department in a tertiary center in Turkey. This retrospective study consisted of 27 cases diagnosed with fetal abdominal wall defects between January 2011 and February 2014 in the perinatology outpatient clinic of Celal Bayar Un... | 25,228,194 | [
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0.03106821,
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0.1993635,
0.3745906,
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... |
Origin of cold bias over the Arabian Sea in Climate Models. | Almost all climate models in Coupled Model Inter-comparison Project phase five (CMIP5) were found to have a cold bias in Sea Surface Temperature (SST) over the northern Arabian Sea, which is linked to the biases in the Indian Summer Monsoon (ISM). This cold SST bias was attributed to the anomalous cold winds from the n... | 25,228,235 | [
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0.05853905,
0.05170338,
0.0165... |
Over 1200-day support with dual Jarvik 2000 biventricular assist device. | We report the successful longest biventricular support using dual Jarvik 2000 biventricular assist device (BVAD; Jarvik Heart, Inc., New York, NY, USA) as a bridge to transplant. A 27-year old woman with arrhythmogenic right ventricular cardiomyopathy underwent implantation of two Jarvik 2000s as a left ventricular ass... | 25,228,243 | [
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-0.1489669,
0.423556,
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0.31... |
Inappropriate prescription of allopurinol and febuxostat and risk of adverse events in the elderly: results from the REPOSI registry. | To investigate the prevalence of xanthine oxidase (XO) inhibitors prescription at admission and discharge in elderly hospital in-patients, to analyze the appropriateness of their use in relation to evidence-based indications, to evaluate the predictors of inappropriate prescription at discharge and the association with... | 25,228,251 | [
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0.06232542,
0.1613989,
-0.4678563,
0.04436753,
-0.1132039,
0.3091177,
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... |
Mechanical stresses, arterial stiffness, and brain small vessel diseases: Shimanami Health Promoting Program Study. | Arterial stiffness, a risk factor of brain small vessel diseases (SVD), causes hemodynamic changes. Mechanical stresses, circumferential wall tension (WT), and shear stress (SS) may change with arterial stiffness and be related to SVD. We investigated the associations between mechanical stresses and arterial stiffness ... | 25,228,261 | [
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0.06302286,
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0.0653974,
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RNA sequencing: current and prospective uses in metabolic research. | Previous global RNA analysis was restricted to known transcripts in species with a defined transcriptome. Next generation sequencing has transformed transcriptomics by making it possible to analyse expressed genes with an exon level resolution from any tissue in any species without any a priori knowledge of which genes... | 25,228,274 | [
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0.3635483,
0.0844772,
-0.2008886,... |
Nutritional interventions for the adjunctive treatment of schizophrenia: a brief review. | Schizophrenia is a chronic condition that impacts significantly not only on the individual and family, but the disorder also has wider consequences for society in terms of significant costs to the economy. This highly prevalent condition affects approximately 1% of the worldwide population, yet there are few therapeuti... | 25,228,271 | [
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0.1379375,
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0.555895,
-0.220687,
... |
Tamoxifen induces apoptosis through cancerous inhibitor of protein phosphatase 2A-dependent phospho-Akt inactivation in estrogen receptor-negative human breast cancer cells. | Tamoxifen, a selective estrogen receptor (ER) modulator, may affect cancer cell survival through mechanisms other than ER antagonism. In the present study, we tested the efficacy of tamoxifen in a panel of ER-negative breast cancer cell lines and examined the drug mechanism. In total, five ER-negative breast cancer cel... | 25,228,280 | [
-0.1560891,
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0.1481882,
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0.3131937,
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0.1146905,
0.1389391,
0.160832,
0.... |
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. BET 1: does restrictive fluid resuscitation in penetrating chest injury affect outcome? | A short cut review was carried out to establish whether restrictive fluid administration in penetrating thoracic trauma impacted on patients' mortality. 143 papers were found using the reported searches, of which three presented the best evidence to answer the clinical question. The author, date and country of publicat... | 25,228,286 | [
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0.1605489,
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0.3425992,
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0.004119387,
0.2186576,
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0.0001146486,
0.1033713,
0.2504331,
0.02434385,... |
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. BET 2: D-dimer levels during normal menstrual cycle. | A short cut review was carried out to establish whether d-dimer concentrations are increased during normal menstruation-. - studies were directly relevant to the question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these papers are ... | 25,228,288 | [
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0.3698784,
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0.1590252,
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0.1172766,
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0.3734869,
-0.179935... |
Influence of lowland forests on subsurface salt accumulation in shallow groundwater areas. | In flat sedimentary plains in areas with a sub-humid climate, tree planting on grasslands and arable lands creates strong hydrological shifts. As a result of deep rooting and high water uptake of trees, groundwater levels drop and subsurface salt accumulation increases. Tree planting has expanded globally and in Hungar... | 25,228,311 | [
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0.1284642,
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0.1058476,
0.2785897,
0.3437648,
-0.02001863,
0.3175669,
0.3467696,
-0.2642592,
-... |
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