title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Porphyromonas gingivalis gingipains selectively reduce CD14 expression, leading to macrophage hyporesponsiveness to bacterial infection. | Cysteine proteases (gingipains) from Porphyromonas gingivalis are key virulence factors in chronic periodontitis. Innate immune receptors CD14, Toll-like receptor (TLR) 2 and TLR4 are important in P. gingivalis recognition. We examined the ability of gingipains to cleave CD14, TLR2 and TLR4, and the consequences for th... | 25,228,314 | [
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Quantitative analysis of resistance to natural killer attacks reveals stepwise killing kinetics. | Molecular mechanisms can protect cancer cells from immune attacks. At the level of bulk tissue, these survival mechanisms are often indistinguishable and simply appear as reduced cell death. However, by tracking individual cell survival and death times, we found broad variation in the kinetics of immune evasion. In res... | 25,228,316 | [
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An experimental study investigating the effect of pain relief from oral analgesia on lumbar range of motion, velocity, acceleration and movement irregularity. | Movement alterations are often reported in individuals with back pain. However the mechanisms behind these movement alterations are not well understood. A commonly cited mechanism is pain. The aim of this study was to investigate the effect of pain reduction, from oral analgesia, on lumbar kinematics in individuals wit... | 25,228,332 | [
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What drove reversions to quadrupedality in ornithischian dinosaurs? Testing hypotheses using centre of mass modelling. | The exceptionally rare transition to quadrupedalism from bipedal ancestors occurred on three independent occasions in ornithischian dinosaurs. The possible driving forces behind these transitions remain elusive, but several hypotheses-including the development of dermal armour and the expansion of head size and cranial... | 25,228,349 | [
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Informed consent form challenges for genetic research in a developing Arab country with high risk for genetic disease. | The prevalence of genetic disease is high in the Middle East, particularly in the United Arab Emirates. Our study assesses the information provided in, and the readability ease of, informed consent forms (ICF) for genetic research studies. A multicenter retrospective cross-sectional review of 54 ICFs was conducted to a... | 25,228,356 | [
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Risk factors of open converted cholecystectomy for cholelithiasis after endoscopic removal of choledocholithiasis. | Open converted cholecystectomy could occur in patients who planned for laparoscopic cholecystectomy after endoscopic removal of choledocholithiasis. To evaluate the risk factors associated with open converted cholecystectomy. The data for all patients who underwent cholecystectomy after endoscopic removal of choledocho... | 25,228,363 | [
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ECSIT bridges RIG-I-like receptors to VISA in signaling events of innate antiviral responses. | Upon binding to RNA structures from invading viruses, RIG-I and MDA5 are recruited to mitochondria to interact with VISA and initiate antiviral type I interferon (IFN) responses. How this process is mediated is less understood. In this report, we demonstrate that ECSIT is an essential scaffolding protein that mediates ... | 25,228,397 | [
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Central emboli rather than saddle emboli predict adverse outcomes in patients with acute pulmonary embolism. | In patients with acute pulmonary embolism (PE), the prognostic implications of saddle or central emboli, as observed on computed tomography (CT), remain to be established. The aim of the present study was to assess whether the presence of saddle and central emboli could be used to predict clinical outcomes in patients ... | 25,228,399 | [
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Hyperpolarized and inert gas MRI: the future. | Magnetic resonance imaging (MRI) is a potentially ideal imaging modality for noninvasive, nonionizing, and longitudinal assessment of disease. Hyperpolarized (HP) agents have been developed in the past 20 years for MR imaging, and they have the potential to vastly improve MRI sensitivity for the diagnosis and managemen... | 25,228,404 | [
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Maternal and perinatal predictors of newborn iron status. | To describe iron status at birth in a population sample of children. Cord blood samples were obtained at birth from 131 infants enrolled in the cohort study Growing Up in New Zealand. Cord blood serum ferritin (SF) and haemoglobin (Hb) concentrations were measured and associations of SF and Hb with maternal and birth c... | 25,228,422 | [
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Prognostic value and long-term variation of high sensitivity troponin T in clinically stable haemodialysis patients. | To provide data on the long-term prognostic relevance and variation of high sensitivity troponin T (hsTnT) in haemodialysis patients. In 238 stable, asymptomatic haemodialysis patients from a single-centre hsTnT was measured at baseline, 18 and 22 months and outcomes assessed for 24 months. Baseline hsTnT was a signifi... | 25,228,425 | [
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Incidence of abnormal retropharyngeal lymph nodes in sinonasal malignancies among adults. | The aim of this study is to investigate the relationship between abnormal retropharyngeal lymph nodes (RPLNs) and sinonasal malignancies among adults. Magnetic resonance and computed tomography images from 89 patients over 20 years old who were all histopathologically confirmed to have sinonasal malignancies from Septe... | 25,228,450 | [
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Drug fever due to a single dose of pantoprazole. | Although proton pump inhibitors (PPI) are generally well tolerated, with most adverse effects being minor and self-limiting, there are singular reports on hypersensitivity immune reactions triggered by a PPI or its metabolites. Here we report a case of acute drug-induced fever with leukocytosis and a transient increase... | 25,228,460 | [
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On-chip sample preparation and analyte quantification using a microfluidic aqueous two-phase extraction coupled with an immunoassay. | Immunoassays are fast and sensitive techniques for analyte quantification, and their use in point-of-care devices for medical, environmental, and food safety applications has potential benefits of cost, portability, and multiplexing. However, immunoassays are often affected by matrix interference effects, requiring the... | 25,228,473 | [
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Genome segment 4 of Antheraea mylitta cytoplasmic polyhedrosis virus encodes RNA triphosphatase and methyltransferases. | Cloning and sequencing of Antheraea mylitta cytoplasmic polyhedrosis virus (AmCPV) genome segment S4 showed that it consists of 3410 nt with a single ORF of 1110 aa which could encode a protein of ~127 kDa (p127). Bioinformatics analysis showed the presence of a 5' RNA triphosphatase (RTPase) domain (LRDR), a S-adenosy... | 25,228,490 | [
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Rationale and Applications of Survival Tree and Survival Ensemble Methods. | Classification and Regression Trees (CART), and their successors-bagging and random forests, are statistical learning tools that are receiving increasing attention. However, due to characteristics of censored data collection, standard CART algorithms are not immediately transferable to the context of survival analysis.... | 25,228,495 | [
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Impaired degradation and aberrant phagocytosis of necrotic cell debris in the peripheral blood of patients with primary Sjögren's syndrome. | Aberrant removal of necrotic debris is considered a feature with inflammatory consequences in SLE. Herein, primary Sjögren's syndrome (SS) patients were investigated for the first time for the capacity of their sera to degrade secondary necrotic cell remnants (SNEC) and DNA (endonuclease DNase1 activity), as well as fo... | 25,228,497 | [
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Rho-kinase inhibitor reduces hypersensitivity to ANG II in human mesenteric arteries retrieved and conserved under the same conditions as transplanted organs. | Rho-kinase and GTP-ase Rho are important regulators of vascular tone and blood pressure. The aim of this study was to investigate the role of Rho-kinase in artery reactions induced by angiotensin II (ANG II) and the effects of ischemia-reperfusion injury as well as the function of intra- and extracellular calcium in th... | 25,228,510 | [
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[Possible involvement of 5-HT₇ receptor in pathophysiology of affective disorders and action of antidepressant drugs]. | The 5-HT7 receptor has recently received considerable attention since its involvement has been implicated in cognitive disturbances, sleep and circadian rhythmicity disorders, anxiety and depression. At the cellular level, 5-HT7 receptors increase the excitability of excitatory cells and appear to modulate both glutama... | 25,228,519 | [
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[The importance of selenium in Hashimoto's disease]. | The aim of this study was to present the current state of knowledge on the role of selenium in the treatment of Hashimoto's disease. In recent years, the number of cases of autoimmune Hashimoto's thyroiditis - a chronic disease that usually leads to hypothyroidism - has increased. Most patients have elevated levels of ... | 25,228,521 | [
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Acute lymphoblastic leukemia in adolescents and young adults. | The cure rate of acute lymphoblastic leukemia (ALL) in children is 80%, compared to less than half in adults. A major proportion of this cure rate drop occurs in adolescents and young adults (AYAs). The age range defining this population varies between studies, biological characteristics are different from both younger... | 25,228,551 | [
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The challenging aspects of managing adolescents and young adults with Hodgkin's lymphoma. | Cancer in the adolescent and young adult (AYA) is the second leading cause of nonaccidental death with hematological malignancies spiking during this period. Treatment of AYAs with hematological malignancies usually follows either pediatric or adult protocols with sufficient information lacking on subgroup analyses reg... | 25,228,552 | [
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Adolescents and young adults with non-Hodgkin's lymphoma: slipping between the cracks. | Adolescents and young adults (AYAs) with cancer have inferior survival as compared to children. The reasons for this survival gap are multifactorial and related to psychosocial aspects, patient- and disease-related biological characteristics as well as to therapeutic approaches within this age span. Non-Hodgkin's lymph... | 25,228,553 | [
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Aplastic anemia in adolescents and young adults. | Adolescent and young adult patient presentations of aplastic anemia require a particular perspective on both diagnosis and treatment. This unique age group necessitates a thorough diagnostic evaluation to ensure the etiology, acquired or inherited, is sufficiently determined. The treatment options include human leukocy... | 25,228,559 | [
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[Treatment of hepatitis C - an imminent revolution]. | Treatment of hepatitis C is approaching a revolution. During the last years, many agents have been developed that directly interfere with the viral replication cycle. Therapy of hepatitis C will no longer need Interferon in the future. The new therapies will be shorter, more efficient and with fewer side effects. For p... | 25,228,574 | [
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[Progressive cutaneous and pulmonary lesions without infectious etiology: two cases reports of sweet syndrome with pulmonary involvement]. | Sweet syndrome is a non infectious febrile disease with a neutrophilic infiltrate of dermis. Extracutaneous involvement can occur. We report two cases of Sweet syndrome with cutaneous and pulmonary involvement and give a short review of the literature of pulmonary involvement in Sweet syndrome. | 25,228,576 | [
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Explicating the role of sexual coercion and vulnerability alcohol expectancies in rape attributions. | Despite evidence suggesting that alcohol expectancies may influence people's rape perceptions, no study to date has measured context-specific expectancies comprehensively. This study represents an initial investigation of the role of sexual coercion and vulnerability alcohol expectancies in young Australian adults' rap... | 25,228,594 | [
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Establishing National Neonatal Perinatal Database and birth defects registry network - need of the hour! | Early detection and prevention of birth defects is necessary to further reduce neonatal morbidity and mortality. A birth defect registry or surveillance system is necessary to assess the exact magnitude, profile and modifiable risk factors for birth defects. We review the existing efforts and suggest possible options f... | 25,228,597 | [
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Molecular copro-prevalence of Cryptosporidium in Egyptian children and evaluation of three diagnostic methods. | To determine molecular prevalence of Cryptosporidium in a cohort of Egyptian children and compare three diagnostic tests. Stool samples from children with diarrhea (n=150) and from apparently healthy children (n=100) were examined for Cryptosporidium using microscopy, enzyme linked immuosorbant assay (ELISA) and nested... | 25,228,606 | [
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ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes. | ZNF750 controls epithelial homeostasis by inhibiting progenitor genes while inducing differentiation genes, a role underscored by pathogenic ZNF750 mutations in cancer and psoriasis. How ZNF750 accomplishes these dual gene regulatory impacts is unknown. Here, we characterized ZNF750 as a transcription factor that binds... | 25,228,645 | [
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Setdb1 is required for germline development and silencing of H3K9me3-marked endogenous retroviruses in primordial germ cells. | Transcription of endogenous retroviruses (ERVs) is inhibited by de novo DNA methylation during gametogenesis, a process initiated after birth in oocytes and at approximately embryonic day 15.5 (E15.5) in prospermatogonia. Earlier in germline development, the genome, including most retrotransposons, is progressively dem... | 25,228,647 | [
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Effect of Cilostazol Following Endovascular Intervention for Peripheral Artery Disease. | Efficacy of endovascular therapy (EVT) with nitinol stents for femoropopliteal (FP) lesions is limited by restenosis. Oral cilostazol reduces angiographic restenosis rate; however, treatment duration remains unclear. In a retrospective analysis of a multicenter database of 3471 consecutive limbs in 2737 patients (mean ... | 25,228,649 | [
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Handling an Isolated Malleus Handle Fracture: Current Diagnostic Work-up and Treatment Options. | An isolated malleus handle fracture is rare and presents with vague otological symptoms. Diagnosis depends on careful history taking and otoscopic examination. Different treatment options are available. Reconstruction with hydroxyapatite bone cement is a relatively new technique. The aim of this article is to review th... | 25,228,668 | [
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Fluoroquinolone use in a child associated with development of osteochondritis dissecans. | Several aetiological theories have been proposed for the development of osteochondritis dissecans. Cartilage toxicity after fluoroquinolone use has been well documented in vitro. We present a case report of a 10-year-old child who underwent a prolonged 18-month course of ciprofloxacin therapy for chronic urinary tract ... | 25,228,675 | [
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Idiopathic intracranial hypertension: Clinical nosography and field-testing of the ICHD diagnostic criteria. A case-control study. | The aims of this article are to characterize the headache in idiopathic intracranial hypertension (IIH) and to field-test the ICHD diagnostic criteria for headache attributed to IIH. We included 44 patients with new-onset IIH. Thirty-four patients with suspected but unconfirmed IIH served as controls. Headache and othe... | 25,228,684 | [
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Unique functional and structural properties of the LRRK2 protein ATP-binding pocket. | Pathogenic mutations in the LRRK2 gene can cause late-onset Parkinson disease. The most common mutation, G2019S, resides in the kinase domain and enhances activity. LRRK2 possesses the unique property of cis-autophosphorylation of its own GTPase domain. Because high-resolution structures of the human LRRK2 kinase domai... | 25,228,699 | [
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High plasma erythropoietin levels are associated with prolonged coma duration and increased mortality in children with cerebral malaria. | Elevated endogenous plasma erythropoietin (EPO) levels have been associated with protection from acute neurologic deficits in Kenyan children with cerebral malaria (CM). Based on these findings and animal studies, clinical trials of recombinant human EPO (rHuEPO) have been started in children with CM. Recent clinical t... | 25,228,706 | [
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Assisted reproductive technology in SLE and APS. | Assisted reproductive technology (ART) procedures, which include in vitro fertilization (IVF), are performed frequently and may be considered for patients with systemic lupus erythematosus and antiphospholipid syndrome. These procedures do not appear to increase the risk of disease flare or thrombosis in these patients... | 25,228,714 | [
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Antiphospholipid scoring: significance in diagnosis and prognosis. | Recently our group introduced the "antiphospholipid score" (aPL-S), a quantitative marker that represents aPL profile. We have validated its efficacy for the diagnosis of antiphospholipid syndrome (APS) and predictive value for thrombosis. The study comprised two independent sets of patients with autoimmune diseases. I... | 25,228,723 | [
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Thrombotic risk assessment in APS: the Global APS Score (GAPSS). | Recently, we developed a risk score for antiphospholipid syndrome (APS) (Global APS Score or GAPSS). This score derived from the combination of independent risk factors for thrombosis and pregnancy loss, taking into account the antiphospholipid antibodies (aPL) profile (criteria and non-criteria aPL), the conventional ... | 25,228,728 | [
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Living-donor lobar lung transplantation provides similar survival to cadaveric lung transplantation even for very ill patients†. | Living-donor lobar lung transplantation (LDLLT) has been performed as a life-saving procedure for critically ill patients who are unlikely to survive the long wait for cadaveric lungs. The purpose of this study was to compare the preoperative condition and outcome of LDLLT patients with those of conventional cadaveric ... | 25,228,745 | [
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Application of caspofungin in China compared with amphotericin B and fluconazole. | Fungal infection has increased in the past 2 decades in China. There are three classes of antifungal drugs, polyenes, azoles, and echinocandins, that are applied frequently in China. Caspofungin, which disrupts the fungal cell wall glucan formation through inhibiting the enzyme 1,3-β-glucan synthase, is one of the echi... | 25,228,811 | [
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Sex differences in long-term outcomes of coronary patients treated with drug-eluting stents at a tertiary medical center. | Limited data exist on contemporary sex-related differences in long-term outcomes of coronary patients receiving drug-eluting stents. In this study we evaluate differences for males (M) and females (F) in 2-year target lesion failure (TLF) in an unselected consecutive series of patients treated with everolimus-eluting s... | 25,228,813 | [
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Bevacizumab in Japanese patients with malignant glioma: from basic research to clinical trial. | An antiangiogenic approach is especially suitable for the treatment of malignant gliomas. Recently, two large clinical trials in newly diagnosed glioblastoma (the Avastin in Glioblastoma study and Radiation Therapy Oncology Group 0825 study) showed a 3- to 4-month prolongation of progression-free survival (PFS) with be... | 25,228,814 | [
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Antiangiogenic cancer drug sunitinib exhibits unexpected proangiogenic effects on endothelial cells. | Angiogenesis, the formation of new blood vessels, is an essential step for cancer progression, but antiangiogenic therapies have shown limited success. Therefore, a better understanding of the effects of antiangiogenic treatments on endothelial cells is necessary. In this study, we evaluate the changes in cell surface ... | 25,228,815 | [
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Lung Parenchymal Signal Intensity in MRI: A Technical Review with Educational Aspirations Regarding Reversible Versus Irreversible Transverse Relaxation Effects in Common Pulse Sequences. | Lung parenchyma is challenging to image with proton MRI. The large air space results in ~l/5th as many signal-generating protons compared to other organs. Air/tissue magnetic susceptibility differences lead to strong magnetic field gradients throughout the lungs and to broad frequency distributions, much broader than w... | 25,228,852 | [
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Facilitated detection of social cues conveyed by familiar faces. | Recognition of the identity of familiar faces in conditions with poor visibility or over large changes in head angle, lighting and partial occlusion is far more accurate than recognition of unfamiliar faces in similar conditions. Here we used a visual search paradigm to test if one class of social cues transmitted by f... | 25,228,873 | [
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Enactivism and neonatal imitation: conceptual and empirical considerations and clarifications. | Recently within social cognition it has been argued that understanding others is primarily characterized by dynamic and second person interactive processes, rather than by taking a third person observational stance. Within this enactivist view of intersubjective understanding, researchers differ in their claims regardi... | 25,228,895 | [
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PeptideManager: a peptide selection tool for targeted proteomic studies involving mixed samples from different species. | The search for clinically useful protein biomarkers using advanced mass spectrometry approaches represents a major focus in cancer research. However, the direct analysis of human samples may be challenging due to limited availability, the absence of appropriate control samples, or the large background variability obser... | 25,228,907 | [
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From bench to bedside: the realities of reducing global prostate cancer disparity in black men. | Prostate cancer in black men of African descent has a different tumour biology compared to those of other races. Its clinical manifestations depict a more aggressive disease with higher morbidity and mortality. This study proposes, through a literature search, identifying applied laboratory and clinical research in pro... | 25,228,914 | [
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Polyisoprenylated methylated protein methyl esterase as a putative drug target for androgen-insensitive prostate cancer. | Prostate cancer (CaP) is the most frequently diagnosed cancer in US men, with an estimated 236,590 new cases and 29,720 deaths in 2013. There exists the need to identify biomarkers/therapeutic targets for the early/companion diagnosis and development of novel therapies against the recalcitrant disease. Mutation and ove... | 25,228,915 | [
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A systems biology approach reveals a link between systemic cytokines and skeletal muscle energy metabolism in a rodent smoking model and human COPD. | A relatively large percentage of patients with chronic obstructive pulmonary disease (COPD) develop systemic co-morbidities that affect prognosis, among which muscle wasting is particularly debilitating. Despite significant research effort, the pathophysiology of this important extrapulmonary manifestation is still unc... | 25,228,925 | [
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O-GlcNAc modification is associated with insulin sensitivity in the whole blood of healthy young adult males. | Hemoglobin A1c (HbA1c) is the predominant diagnostic tool for diabetes diagnosis and progression. However, it has proven to be insensitive at pre-diabetic threshold values. O-linked-β-N-acetylglucosamine (O-GlcNAc) modification has emerged as a sensitive biomarker. The purpose of this study was to explore the sensitivi... | 25,228,926 | [
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International electives in the final year of German medical school education--a student's perspective. | The final year of medical school has a unique role for introducing students to their future responsibilities and challenges. At many medical schools, electives at an accredited institution abroad are a common part of the student's final year experience. International electives provide an opportunity for a personal and ... | 25,228,928 | [
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Hands-on - general medicine - circuit-training in the auditorium--a practical equivalent to a lecture. | Traditional university teaching formats are of limited use when it comes to conveying the inner workings and specific remit of general medicine in a practical way. Small supervised groups present themselves as a plausible and effective alternative for learning to interact with patients in low prevalence areas. A fronta... | 25,228,929 | [
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Laparoscopy for ventriculoperitoneal shunt implantation and revision surgery. | Ventriculoperitoneal shunting (VPS) is a widely accepted technique for the treatment of hydrocephalus. The probability of shunt dysfunction is pretty high throughout life. Laparoscopy has become a valuable tool to perform VPS and treat abdominal complications. An electronic literature search was performed to reveal the... | 25,228,943 | [
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Innate immune receptors in heart failure: Side effect or potential therapeutic target? | Heart failure (HF) is a leading cause of mortality and morbidity in western countries and occasions major expenses for public health systems. Although optimal medical treatment is widely available according to current guidelines, the prognosis of patients with HF is still poor. Despite the etiology of the disease, incr... | 25,228,958 | [
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Risk stratification for ST segment elevation myocardial infarction in the era of primary percutaneous coronary intervention. | Acute coronary syndromes presenting with ST elevation are usually treated with emergency reperfusion/revascularisation therapy. In contrast current evidence and national guidelines recommend risk stratification for non ST segment elevation myocardial infarction (NSTEMI) with the decision on revascularisation dependent ... | 25,228,966 | [
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Late intervention in an asymptomatic pediatric patient with anomalous left coronary artery. | Anomalous left coronary artery from the pulmonary artery (ALCAPA) is most commonly diagnosed within the first year of life with congestive heart failure symptomatology reflecting left ventricle (LV) dysfunction. The late diagnosis of ALCAPA is presented in a 5-year-old without significant LV dysfunction, mild LV dilata... | 25,228,967 | [
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Long-term efficacy of endoscopic submucosal dissection compared with surgery for early gastric cancer: a retrospective cohort study. | This study aimed to compare the outcomes of endoscopic submucosal dissection (ESD) and gastrectomy based on the two sets of indications for ESD, namely guideline criteria (GC) and expanded criteria (EC). Between January 2004 and July 2007, 213 early gastric cancer (EGC) patients were enrolled in this study. Of these pa... | 25,228,976 | [
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Is endoscopic retrograde cholangiopancreatography safe in patients 90 years of age and older? | This case-control study evaluated the safety and efficacy of endoscopic retrograde cholangiopancreatography (ERCP) in patients 90 years of age and older. From January 2005 to August 2011, 5,070 cases of ERCP were performed at our institution. Of these, 43 cases involved patients 90 years of age and older (mean age, 91.... | 25,228,977 | [
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Allergic diseases and multiple chemical sensitivity in korean adults. | Multiple chemical sensitivity (MCS) is a clinical syndrome representing multi-organ and psychological symptoms caused by chronic exposure to various chemicals in low concentrations. We evaluated the prevalence and related factors of MCS targeting Korean adults using the Quick Environmental Exposure and Sensitivity Inve... | 25,228,997 | [
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Exploring Household-level Risk Factors for Self-reported Prevalence of Allergic Diseases Among Low-income Households in Seoul, Korea. | Indoor risk factors for allergic diseases in low-income households in Korea have been characterized only partially. We evaluated the prevalences of atopic dermatitis, asthma, and allergic rhinitis in Seoul, Korea, to identify key housing and behavioral risk factors of low-income households. Statistical analysis of the ... | 25,228,999 | [
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The impact of asthma control on salivary cortisol level in adult asthmatics. | Asthma is a chronic disease causing psychological stress which leads to the activation of hypothalamus-pituitary-adrenal axis. The purpose of this study is to compare morning salivary cortisol levels in persistent asthma patients according to their disease severities and control status. Total 206 adult asthma patients ... | 25,229,005 | [
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Effect of constraint-induced movement therapy and mirror therapy for patients with subacute stroke. | To evaluate the effectiveness of constraint-induced movement therapy (CIMT) and combined mirror therapy for inpatient rehabilitation of the patients with subacute stroke. Twenty-six patients with subacute stroke were enrolled and randomly divided into three groups: CIMT combined with mirror therapy group, CIMT only gro... | 25,229,024 | [
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Activations of deep lumbar stabilizing muscles by transcutaneous neuromuscular electrical stimulation of lumbar paraspinal regions. | To investigate changes in lumbar multifidus (LM) and deep lumbar stabilizing abdominal muscles (transverse abdominis [TrA] and obliquus internus [OI]) during transcutaneous neuromuscular electrical stimulation (NMES) of lumbar paraspinal L4-L5 regions using real-time ultrasound imaging (RUSI). Lumbar paraspinal regions... | 25,229,029 | [
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Medical management for intractable pain arising from primary sjögren syndrome involving both brain and spinal cord: a case report. | Primary Sjögren syndrome, which involves lesions in both the brain and spinal cord, is rarely reported. Related symptoms, such as intractable pain due to central nervous system involvement, are very rare. A 73-year-old woman diagnosed with primary Sjögren syndrome manifested with subacute encephalopathy and extensive t... | 25,229,038 | [
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Total knee arthroplasty in a patient with an ankylosing knee after previous patellectomy. | Patellectomized patients may have less satisfactory clinical outcomes following total knee arthroplasty (TKA) due to a decreased extensor mechanism efficiency and potential instability. Furthermore, the existing literature does not provide concrete guidance on the expected results of TKA or the type of implant that sho... | 25,229,049 | [
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Lean mass is the strongest predictor of bone mineral content in type-2 diabetes and normal individuals: an eastern India perspective. | Impact of body fat distribution on bone mineral content (BMC) and density (BMD) at different sites has not been studied in type-2 diabetes (T2DM). This study aimed to compare BMC and BMD in normal (BMI < 25 kg/m(2)) and increased BMI (BMI ≥ 25 kg/m(2)) T2DM patients with age and BMI matched normal controls, and eval... | 25,229,052 | [
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Molecular level computational studies of polyethylene and polyacrylonitrile composites containing single walled carbon nanotubes: effect of carboxylic acid functionalization on nanotube-polymer interfacial properties. | Molecular dynamics (MD) and molecular mechanics (MM) methods have been used to investigate additive-polymer interfacial properties in single walled carbon nanotube (SWNT)-polyethylene and SWNT-polyacrylonitrile composites. Properties such as the interfacial shear stress and bonding energy are similar for the two compos... | 25,229,056 | [
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How to follow the NEWS. | it is not known how best to respond to changes in the National Early Warning Score (NEWS) after hospital admission. This report manipulates and extrapolates previously published data on the trajectories of the abbreviated early warning score (AbEWS i.e. NEWS that does not include mental status). trajectories of average... | 25,229,059 | [
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Problem based review: the pregnant woman presenting to the AMU with palpitations. | Pregnant patients commonly present to the acute medical team with symptoms requiring further investigation. Palpitations are a common reason for presentation on the acute medical take, and most acute physicians will be familiar with the process of investigation. The combination of pregnancy and palpitations raises a br... | 25,229,066 | [
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Quantum cutting in nanoparticles producing two green photons. | A synthetic route to nanoscale NaGdF4:Ln is presented which allows for quantum cutting based on the Gd-Er-Tb system. This shows, that cross-relaxation and other energy transfer processes necessary for multiphoton emission can be achieved in nanoparticles even if the large surface and the potentially huge amount of kill... | 25,229,069 | [
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A cellulose based hydrophilic, oleophobic hydrated filter for water/oil separation. | A hydrated regular cellulose paper filter modified with nanofibrillated cellulose (NFC) hydrogel was successfully fabricated for water/oil separation. The fabricated filter's hydrophilic and oleophobic properties resulted in increased filter life and decreased environmental impact, while displaying water flux of 89.6 L... | 25,229,071 | [
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From a historic review to horizons beyond: lithium-sulphur batteries run on the wheels. | In terms of sustainable development and environmental issues, the design and fabrication of efficient energy storage devices will be more critical in the future than at any time in the past. Li-S batteries are promising candidates for such a purpose due to their high specific capacity and low environmental impact. This... | 25,229,072 | [
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Redescription of Paragaleus tengi (Chen, 1963) (Carcharhiniformes: Hemigaleidae) and first record of Paragaleus randalli Compagno, Krupp & Carpenter, 1996 from the western North Pacific. | Paragaleus tengi was previously considered to be the only member of this genus occurring in the Western Pacific, with Paragaleus randalli occurring in the Indian Ocean and allopatric in distribution. Recent molecular and morphological studies showed that P. randalli also occurs in the Western Pacific with records from ... | 25,229,113 | [
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The transmembrane domain peptide of vesicular stomatitis virus promotes both intermediate and pore formation during PEG-mediated vesicle fusion. | We propose mechanisms by which the transmembrane domain of vesicular stomatitis virus (VSV-TMD) promotes both initiation of fusion and formation of a fusion pore. Time courses of polyethyleneglycol (PEG)-mediated fusion of 25 nm small unilamellar vesicles composed of dioleoylphosphatidylcholine, dioleoylphosphatidyleth... | 25,229,140 | [
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Water penetration profile at the protein-lipid interface in Na,K-ATPase membranes. | The affinity of ionized fatty acids for the Na,K-ATPase is used to determine the transmembrane profile of water penetration at the protein-lipid interface. The standardized intensity of the electron spin echo envelope modulation (ESEEM) from (2)H-hyperfine interaction with D2O is determined for stearic acid, n-SASL, sp... | 25,229,145 | [
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Sensor-based electromagnetic navigation to facilitate implantation of left ventricular leads in cardiac resynchronization therapy. | Implantation of cardiac resynchronization therapy (CRT) devices can be challenging, time consuming, and fluoroscopy intense. To facilitate placement of left ventricular (LV) leads, a novel electromagnetic navigation system (MediGuide™, St. Jude Medical, St. Paul, MN, USA) has been developed, displaying real-time 3-D lo... | 25,229,158 | [
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Exposure to peer deviance during childhood and risk for drug abuse: a Swedish national co-relative control study. | Peer deviance (PD) is associated with risk for drug abuse (DA). Is this association causal? DA was recorded in official records. PD was defined as the percentage of peers residing in small communities with future DA registrations. We examined offspring in families whose community PD changed when the offspring was 0-15 ... | 25,229,163 | [
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Impact of lifestyle factors on caries experience in three different age groups: 9, 15, and 21-year-olds. | To study the impact of lifestyle factors on dental caries experiences in addition to the effect of demographic characteristics at the ages of 9, 15, and 21 years. The data were obtained from the study 'Oral health in children and adolescents in the Netherlands'. Data were collected through questionnaires and a clinical... | 25,229,181 | [
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The effect of the section thickness used for 2- and 3-dimensional quantification of dual-energy perfusion computed tomography. | To retrospectively investigate the effect of the section thickness used for quantifying dual-energy perfusion computed tomography (DEpCT) during 2- and 3-dimensional evaluation. Sixty-six patients (22 males and 44 females; mean age, 59.3 years) suspected of having an acute pulmonary embolism underwent DEpCT, and 15pati... | 25,229,200 | [
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Laboratory evaluation of the development of Aedes aegypti in two seasons: influence of different places and different densities. | Aedes aegypti is an important vector in Brazil being the main vector of the dengue-fever. This paper employs survival curves to describe the time in days from larvae to adult forms of Aedes aegypti raised, individually and collectively, and compares it during winter and spring when positioned inside and outside a labor... | 25,229,215 | [
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-0.01542492,
-0.07378208,
-0.3634524,
-0.2168345,
-0.1635142,
-0.03943507,
-0.1240891,
-0.3349351,
0.02644691,
-0.02451154,
0.0008558069,
-0.2354546,
-0.2719788,
-0.3369599,
0.2005146,
0.1557219,
0.07500149,
0.0957054,
0.03115032,
0.2262988,
-0.1321... |
Detection of Leishmania (Viannia) IN Nyssomyia neivai and Nyssomyia whitmani by multiplex polymerase chain reaction, in Southern Brazil. | Sandflies transmit pathogens of leishmaniasis. The natural infection of sandflies by Leishmania (Viannia) was assessed in municipalities, in the state of Paraná, in Southern Brazil. Sandflies were collected with Falcão and Shannon traps. After dissection in search of flagellates in digestive tubes and identification of... | 25,229,218 | [
0.1064771,
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0.2105847,
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0.1217665,
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0.1186295,
... |
Do girls have a nutritional disadvantage compared with boys? Statistical models of breastfeeding and food consumption inequalities among Indian siblings. | India is the only nation where girls have greater risks of under-5 mortality than boys. We test whether female disadvantage in breastfeeding and food allocation accounts for gender disparities in mortality. Secondary, publicly available anonymized and de-identified data were used; no ethics committee review was require... | 25,229,235 | [
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0.4517109,
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High visceral leishmaniasis mortality rate in Barra Mansa, a new area of visceral leishmaniasis transmission in the State of Rio de Janeiro, Brazil. | Nine cases of visceral leishmaniasis occurred recently in Barra Mansa, State of Rio de Janeiro, with a high mortality rate. We reviewed the medical records of the patients. Eight were male; 7 were adults. Patients who died progressed to death quickly and presented with aggravating factors: systemic steroid therapy befo... | 25,229,297 | [
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Use of density functional theory orbitals in the GVVPT2 variant of second-order multistate multireference perturbation theory. | A new variation of the second-order generalized van Vleck perturbation theory (GVVPT2) for molecular electronic structure is suggested. In contrast to the established procedure, in which CASSCF or MCSCF orbitals are first obtained and subsequently used to define a many-electron model (or reference) space, the use of an... | 25,229,307 | [
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Three-component bicyclization providing an expedient access to pyrano[2',3':5,6]pyrano[2,3-b]pyridines and its derivatives. | A new three-component bicyclization for the efficient synthesis of a fused pyrano[2,3-b]pyridine library has been developed. The syntheses were achieved by reacting diverse C,O-containing nucleophiles, aldehydes, and 2-aminoprop-1-ene-1,1,3-tricarbonitrile under microwave irradiation, providing 50 examples of chemicall... | 25,229,308 | [
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0.3076905,
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... |
Wollamides: antimycobacterial cyclic hexapeptides from an Australian soil Streptomyces. | A soil Streptomyces nov. sp. (MST-115088) isolated from semiarid terrain near Wollogorang Station, Queensland, returned two known and two new examples of a rare class of cyclic hexapeptide, desotamides A and B (1 and 2) and E and F (3 and 4), respectively, together with two new d-Orn homologues, wollamides A and B (5 a... | 25,229,313 | [
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0.3008788,
0.2932248,
0.001078236,
0.3997034,
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[Inhalation therapy, patient's perspective]. | The cornerstone of drug application in obstructive pulmonary diseases is by inhalation as advocated by all treatment guidelines. Today, there exists an extensive choice of inhalers and new models. Numerous inhaler types are constantly being developed and introduced into the market making the "correct" selection a weary... | 25,229,316 | [
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0.1258744,
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Seasonal plasticity in telencephalon mass of a benthic fish. | To gain a deeper understanding of how environmental conditions affect brain plasticity, brain size was explored across different seasons using the invasive round goby Neogobius melanostomus. The results show that N. melanostomus had heavier telencephalon in the spring compared to the autumn across the two years of stud... | 25,229,327 | [
-0.08475206,
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0.2696886,
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0.1000247,
0.02382371,
0.293864,
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Involvement of IQGAP family proteins in the regulation of mammalian cell cytokinesis. | IQGAP family proteins, comprising IQGAP1, -2, and -3 in mammals, are involved in diverse ranges of cellular processes such as adhesion and migration. IQGAP proteins in yeast also play important roles in cytokinesis. However, the involvement of IQGAP proteins in cytokinesis in mammals remains unaddressed. In this study,... | 25,229,330 | [
-0.157725,
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0.2342311,
0.4216651,
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-0... |
Binding of a Smad4/Ets-1 complex to a novel intragenic regulatory element in exon12 of FPGS underlies decreased gene expression and antifolate resistance in leukemia. | Polyglutamylation of antifolates catalyzed by folylpoly-γ-glutamate synthetase (FPGS) is essential for their intracellular retention and cytotoxic activity. Hence, loss of FPGS expression and/or function results in lack of antifolate polyglutamylation and drug resistance. Members of the TGF-β/Smad signaling pathway are... | 25,229,333 | [
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0.2396697,
0.2725757,
0.01280246,
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-0.00... |
Urinary L-FABP predicts poor outcomes in critically ill patients with early acute kidney injury. | Biomarker studies for early detection of acute kidney injury (AKI) have been limited by nonselective testing and uncertainties in using small changes in serum creatinine as a reference standard. Here we examine the ability of urine L-type fatty acid-binding protein (L-FABP), neutrophil gelatinase-associated lipocalin (... | 25,229,339 | [
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0.2441015,
0.1303644,
0.08111098,
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0.241213,
-0.3123537,
-0.0... |
[Pharmaceutical intervention in duration of antimicrobial treatment at hospital ambit]. | To estimate the acceptance of the pharmaceutical intervention in controlling duration of antimicrobial therapy and to evaluate their impact on optimizing the treatment. Prospective observational study for two years in a General University Hospital. For the patients record, we followed non critical adult patients with a... | 25,229,371 | [
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0.3126822,
0.2691485,
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0.04044382,
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0.3615423,
-... |
Emergency contraception in Senegal: challenges and opportunities. | This paper highlights lessons from introductory efforts and presents new data on community, provider and key opinion leader perspectives to support expanded use of emergency contraception (EC) in Senegal. The paper draws on four data sources: (i) a literature review; (ii) a secondary analysis of a household survey cond... | 25,229,389 | [
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0.2241388,
0.1100319,
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0.01645158,
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0.1034726,
0.3953034,
0.07806398,
-0.0302478,
... |
Are Re(i) phenanthroline complexes suitable candidates for OLEDs? Answers from DFT and TD-DFT investigations. | The electronic structure and spectroscopic properties of seven recently reported rhenium(i) phenanthroline complexes were investigated theoretically by density functional theory (DFT) and time dependent density functional theory (TD-DFT) methods. All the seven complexes are shown here to be better electron transport ma... | 25,229,400 | [
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0.3427532,
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0.3971717,
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Effects of dietary pyrroloquinoline quinone disodium on growth performance, carcass yield and antioxidant status of broiler chicks. | Pyrroloquinoline quinone (PQQ), a putative essential nutrient and redox modulator in microorganisms, cell and animal models, has been recognized as a growth promoter in rodents. Growth performance, carcass yield and antioxidant status were evaluated on broiler chickens fed different levels of PQQ disodium (PQQ.Na2). A ... | 25,229,409 | [
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-0.3051798,
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0.2228518,
0.2781175,
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0.09870778,
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-... |
Comparison of four methods to assess erosive substance loss of dentin. | Erosion of dentin results in a complex multi-layered lesion. Several methods have been used to measure erosive substance loss of dentin, but were found to have only limited agreement, in parts because they assess different structural parameters. The present study compared the agreement of four different methods (transv... | 25,229,410 | [
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0.08810895,
0.3... |
The emerging role of the peptidome in biomarker discovery and degradome profiling. | The peptidome represents the array of endogenous peptides that are present in both the intracellular and extracellular space of the body. Peptides are constantly generated in vivo by active synthesis, and by proteolytic processing of larger precursor proteins, often yielding protein fragments that mediate a variety of ... | 25,229,414 | [
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0.06522395,
-0.120706,
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0.1729987,
-0.2839987,
... |
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