title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Personality traits measured at baseline can predict academic performance in upper secondary school three years late. | The aim of the present study was to explore the ability of personality to predict academic performance in a longitudinal study of a Swedish upper secondary school sample. Academic performance was assessed throughout a three-year period via final grades from the compulsory school and upper secondary school. The Big Five... | 25,257,093 | [
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Model of voluntary ethanol intake in zebrafish: effect on behavior and hypothalamic orexigenic peptides. | Recent studies in zebrafish have shown that exposure to ethanol in tank water affects various behaviors, including locomotion, anxiety and aggression, and produces changes in brain neurotransmitters, such as serotonin and dopamine. Building on these investigations, the present study had two goals: first, to develop a m... | 25,257,106 | [
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[Online addictive disease]. | Digital media are indispensable in school, profession, family and leisure time. 1 to 6 % of all users show dsyfunctional ans addictive patterns, first of all in online and "social" media. In Switzerland over 80 % of young people own a smartphone and "pocket internet". Time of interaction with online-media (hours/day), ... | 25,257,114 | [
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It began with a daydream: the 150th anniversary of the Kekulé benzene structure. | In January 1865, August Kekulé published his theory of the structure of benzene, which he later reported had come to him in a daydream about a snake biting its tail. Although other theories had been postulated before 1865, Kekulé was the first to identify the correct structure. Kekulé's theory resulted in a clear under... | 25,257,125 | [
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Analysis of potentially predictive factors of efficacy of adjunct extended-release quetiapine fumarate in patients with major depressive disorder. | Identification of predictors of treatment response in patients with major depressive disorder (MDD) may facilitate improved disease management. Data were pooled from two 6-week, double-blind, placebo-controlled studies of extended-release quetiapine (quetiapine XR; 150 or 300 mg/day) as adjunct to ongoing antidepressan... | 25,257,148 | [
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Dry ice exposure of plasma samples influences pH and lupus anticoagulant analysis. | Tests for lupus anticoagulant (LA), including silica clotting time (SCT) and diluted Russel's viper venom time (dRVVT) are used to diagnose antiphospholipid syndrome. Due to sample instability, it is recommended that samples are frozen if analysis is postponed >4 h. Shipping on dry ice is common practice to keep sam... | 25,257,161 | [
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Integrated, cascading enzyme-/chemocatalytic cellulose conversion using catalysts based on mesoporous silica nanoparticles. | This article reports a novel approach to deconstructing cellulose into 5-hydroxymethylfurfural (HMF) with a high yield (46.1%) by integrating a sequential enzyme cascade technique in an aqueous system with solid acid catalysis in an organic-solvent system. We executed the rational design and synthesis of mesoporous sil... | 25,257,168 | [
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Effects of hatchery rearing on Florida largemouth bass Micropterus floridanus resource allocation and performance under semi-natural conditions. | This study examined the growth, activity, metabolism and post-release survival of three groups of Florida largemouth bass Micropterus floridanus: wild-caught fish, hatchery fish reared according to standard practice (hatchery standard) and hatchery fish reared under reduced and unpredictable food provisioning (hatchery... | 25,257,181 | [
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Effects of intestinal microbiota on the bioavailability of geniposide in rats. | This study investigated the effects of intestinal microbiota on the metabolism of geniposide by using a rat model treated with a mixture of antibiotics. The plasma concentration of geniposide was determined after oral administration in control and antibiotics-treated rats by using liquid chromatography-tandem mass spec... | 25,257,195 | [
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Selective anion-induced crystal switching and binding in surface monolayers modulated by electric fields from scanning probes. | Anion-selective (Br(-) and I(-)) and voltage-driven crystal switching between two differently packed phases (α ⇆ β) was observed in 2D crystalline monolayers of aryl-triazole receptors ordered at solution-graphite interfaces. Addition of Br(-) and I(-) was found to stimulate the α → β phase transformation and to produc... | 25,257,197 | [
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Modeling human neural functionality in vitro: three-dimensional culture for dopaminergic differentiation. | Advances in mechanistic knowledge of human neurological disorders have been hindered by the lack of adequate human in vitro models. Three-dimensional (3D) cellular models displaying higher biological relevance are gaining momentum; however, their lack of robustness and scarcity of analytical tools adapted to three dime... | 25,257,211 | [
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Capillary electrophoresis in two-dimensional separation systems: Techniques and applications. | The analysis of complex samples requires powerful separation techniques. Here, 2D chromatographic separation techniques (e.g. LC-LC, GC-GC) are increasingly applied in many fields. Electrophoretic separation techniques show a different selectivity in comparison to LC and GC and very high separation efficiency. Thus, 2D... | 25,257,214 | [
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Ergometer training volume and previous injury predict back pain in rowing; strategies for injury prevention and rehabilitation. | The most commonly reported injury site in rowers is the lower back. Research in recent years has focused on epidemiology and biomechanical analyses to try and understand mechanisms that contribute to this injury's onset. Injury surveillance mainly comprises retrospective questionnaires and reviews of medical records wi... | 25,257,230 | [
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Cluster hole versus solid cup in total hip arthroplasty: a randomized control trial. | Acetabular osteolysis has been linked to polyethylene debris that is generated in the hip migrating through screw holes in the acetabular component. Solid-backed acetabular components were designed to decrease this osteolysis. This prospective trial randomized 100 patients undergoing total hip arthroplasty to either a ... | 25,257,236 | [
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Venous thromboembolism and mortality associated with tranexamic acid use during total hip and knee arthroplasty. | TKA and THA are associated with blood transfusion and risk for postoperative venothromboembolism (VTE). Reports show that tranexamic acid (TA) may be safe to use in high-risk orthopedic patients, but further data are needed to substantiate its use. All patients who underwent primary or revision TKA or THA in a five yea... | 25,257,237 | [
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Gene mutations in Mycobacterium tuberculosis: multidrug-resistant TB as an emerging global public health crisis. | Against a constant background of established infections, epidemics of new and old infectious diseases periodically emerge, greatly magnifying the global burden of infections. TB poses formidable challenges to the global health at the public health and scientific level by acquiring gene mutation into anti TB drugs speci... | 25,257,261 | [
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[Manganese-enhanced magnetic resonance imaging for studying olfactory dysfunction in rats]. | To study the olfactory function in rats by manganese-enhanced magnetic resonance imaging (MEMRI) and explore the regeneration of olfactory system from the imaging. Thirty-five adult male Sprague-Dawley (SD) rats were randomly divided into three groups. Twenty rats with bilateral nasal instillation of TritonX-100 were u... | 25,257,276 | [
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Lentiviral vector-mediated dopamine d3 receptor modulation in the rat brain impairs alcohol intake and ethanol-induced conditioned place preference. | It has been reported that dopamine D3 receptor (D3R) knockout mice display similar ethanol (EtOH) consumption compared to wild types. In addition, studies with D3R pharmacological targeting were inconclusive. In the current study, we used both gain- and loss-of-function approaches to test the effects of central D3R man... | 25,257,287 | [
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U.S. trends in light, moderate, and heavy drinking episodes from 2000 to 2010. | Risks and potential benefits associated with alcohol use vary with the amount of alcohol consumed on a drinking occasion. Over time, changes in the absolute and relative numbers of light or heavy drinking episodes may occur, impacting health and social problems. Analyses of the 2000, 2005, and 2010 National Alcohol Sur... | 25,257,297 | [
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Increased expression of insulin-like growth factor-1 receptor is correlated with worse survival in canine appendicular osteosarcoma. | Insulin-like growth factor 1 receptor (IGF-1R) is a cell membrane receptor widely expressed in tissues and involved in different cancers in humans. IGF-1R expression in human osteosarcoma has been associated with the development of tumour metastasis and with prognosis, and represents an attractive therapeutic target. T... | 25,257,352 | [
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Role of vitamin D3 in treatment of lumbar disc herniation--pain and sensory aspects: study protocol for a randomized controlled trial. | Vitamin D receptors have been identified in the spinal cord, nerve roots, dorsal root ganglia and glial cells, and its genetic polymorphism association with the development of lumbar disc degeneration and herniation has been documented. Metabolic effects of active vitamin D metabolites in the nucleus pulposus and annul... | 25,257,359 | [
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Impact of individual extracellular proteases on Staphylococcus aureus biofilm formation in diverse clinical isolates and their isogenic sarA mutants. | We demonstrate that the purified Staphylococcus aureus extracellular proteases aureolysin, ScpA, SspA, and SspB limit biofilm formation, with aureolysin having the greatest impact. Using protease-deficient derivatives of LAC, we confirmed that this is due to the individual proteases themselves. Purified aureolysin, and... | 25,257,373 | [
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Childbearing traditions of Indian women at home and abroad: An integrative literature review. | The percentage of overseas-born mothers giving birth in Australia has increased to 31.5% in 2012 and Indian women represent 10% (the highest proportion). It is important for midwives in Australia to be aware of the childbearing traditions of Indian women and how these influence Indian women birthing in Australia. To ex... | 25,257,377 | [
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Ungated radial quiescent-inflow single-shot (UnQISS) magnetic resonance angiography using optimized azimuthal equidistant projections. | We hypothesized that non-contrast-enhanced MR angiography (NEMRA) could be performed without cardiac gating by using a variant of the quiescent-inflow single-shot (QISS) technique. Ungated QISS (UnQISS) MRA was evaluated in eight patients with peripheral arterial disease at 1.5T. The radial acquisition used optimized a... | 25,257,379 | [
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Transient overexpression of Werner protein rescues starvation induced autophagy in Werner syndrome cells. | Reduced autophagy may be associated with normal and pathological aging. Here we report a link between autophagy and Werner protein (WRNp), mutated in Werner syndrome, the human premature aging Werner syndrome (WS). WRN mutant fibroblast AG11395 and AG05229 respond weakly to starvation induced autophagy compared to norm... | 25,257,404 | [
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Involvement of NF-κB-dependent signaling and p38 MAPK signaling pathway in the regulation of hemopoiesis during restrain stress. | Protein kinase p38 was shown to contribute to the increase in production of granulocyte CSF by microenvironmental cells under conditions of restraint stress. Stimulation of colony-forming activity was not accompanied by the increase in maturation of clonogenic structures in the bone marrow granulocytic stem. This proce... | 25,257,409 | [
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Effect of anticonvulsant therapy for absence epilepsy on heart function. | Monitoring of the heart status during increasing stress-induced load allowed us to evaluate heart function after treatment of absence epilepsy with anticonvulsants of various types of action. Functional load against the background of treatment with lamotrigine or convulex had different effects on the dynamics of heart ... | 25,257,412 | [
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Effects of hormones on in vitro maturation of cattle oocytes. | The efficiency of cattle oocyte maturation in vitro was studied in protein-free MEM-α with hormones and in completely definite culture medium without hormones. Oocyte capacity to develop after fertilization to the morula/blastocyst and blastocyst stages served as a criterion of effective maturation. The increase in fol... | 25,257,429 | [
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... |
Regional lymph nodes in the liver of rats in functional pinealectomy. | The effects of functional pinealectomy on the morphological organization of the regional lymph nodes in the liver of rats were studied. Shrinkage of follicles (with increased percentage of germinative centers in them) and reduced count of mature lymphoid cells in the medullary cords indicated more intense migration of ... | 25,257,433 | [
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Argyrophilic proteins of nucleolar organizer regions and proliferative activity of cells in squamous cell carcinoma of the lung. | Argyrophilic proteins associated with nucleolar organizer regions (Ag-NOR proteins) and Ki-67 antigen were analyzed in 118 samples of squamous cell carcinoma of the lungs. Tumors with low and high content of Ag-NOR proteins and Ki-67 index were selected. It was found that the content of Ag-NOR proteins correlated with ... | 25,257,439 | [
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[A virtual deformable mandible model used for reconstruction computer aided design of large mandibular defects]. | To establish a three- dimensional virtual deformable mandible model used for individual reconstruction design of large mandibular defect. A virtual deformable mandible model has been established by a 3D animation software. The model could be used for preoperative reconstruction design of large mandibular defects cases.... | 25,257,455 | [
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Atrial natriuretic peptide vs. N-terminal-pro-atrial natriuretic peptide for the detection of left atrial dilatation in horses. | Studies on the use of atrial natriuretic peptide (ANP) as a biomarker for left atrial dilatation in horses have produced variable results. Few have been performed, and the results may have been influenced by ANP instability, differences in sampling protocol and changes in the assay over time. N-Terminal proANP (NT-proA... | 25,257,480 | [
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Physical examination of the shoulder. | This article summarizes the overall assessment of the shoulder joint and seeks to help direct clinicians to diagnose shoulder pathology using standard and specific physical examinations. The history and standard examination can prompt the examiner to focus on specific tests to further evaluate the shoulder and limit th... | 25,257,491 | [
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Management of fingertip amputations. | Injuries to the fingertips are among the most common injuries to the hand and result in approximately 4.8 million emergency department visits per year. Most injuries are lacerations or crushes; amputations represent a small but complex spectrum of injury. Treatments available cover a broad range of techniques with no s... | 25,257,490 | [
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University students' knowledge and attitudes regarding cervical cancer, human papillomavirus, and human papillomavirus vaccines in Turkey. | The current descriptive study aimed to determine university students' knowledge and attitudes regarding cervical cancer, human papillomavirus (HPV), and HPV vaccines in Turkey. A total of 800 students participated. This study was carried out between September 1, 2012, and October 30, 2012, in 8 female dormitories. In r... | 25,257,501 | [
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Telomere functions grounding on TERRA firma. | Long noncoding telomeric repeat-containing RNAs - TERRAs - are transcribed in a regulated manner from telomeres throughout eukaryotes. TERRA molecules consist of chromosome end-specific subtelomeric sequences and telomeric repeats at their 3' ends. Recent work suggests that TERRA sustains several important functions at... | 25,257,515 | [
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Increased REM sleep after intra-locus coeruleus nucleus microinjection of melanin-concentrating hormone (MCH) in the rat. | A study was carried out on the effects of unilateral microinjection of melanin-concentrating hormone (MCH) into the right locus coeruleus (LC) on the sleep-wake cycle in rats prepared for chronic sleep recordings. MCH 200 ng significantly augmented rapid-eye-movement sleep (REMS) time during the first, second and third... | 25,257,545 | [
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Genetic susceptibility to total hip arthroplasty failure: a case-control study on the influence of MMP 1 gene polymorphism. | Genetic factors plays an important role in early failure of total hip arthroplasty (THA) etiology and MMP-1 gene polymorphism rs5854 may be involved. The present study was conducted to reveal the possible association between MMP-1 rs5854 C/T polymorphism and the risk of early failure of THA (aseptic loosening). The rs5... | 25,257,555 | [
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Human papillomavirus among women with atypical squamous cells of undetermined significance in southern Brazil. | To determine the prevalence of atypical squamous cells of undetermined significance (ASCUS) and human papillomavirus (HPV) genotypes in a population in southern Brazil. In a retrospective cross-sectional study, the prevalence of ASCUS was determined among women aged 20-60 years who were referred to a private medical ce... | 25,257,569 | [
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A coupled thermodynamic and metabolic control analysis methodology and its evaluation on glycerol biosynthesis in Saccharomyces cerevisiae. | A coupled in silico thermodynamic and probabilistic metabolic control analysis methodology was verified by applying it to the glycerol biosynthetic pathway in Saccharomyces cerevisiae. The methodology allows predictions even when detailed knowledge of the enzyme kinetics is lacking. In a metabolic steady state, we foun... | 25,257,590 | [
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Characterization of a new endo-type polyM-specific alginate lyase from Pseudomonas sp. | An alginate lyase gene, algA, encoding a new poly β-D-mannuronate (polyM)-specific alginate lyase AlgA, was cloned from Pseudomonas sp. E03. The recombinant AlgA with (His)6-tag, consisting of 364 amino acids (40.4 kDa),was purified using Ni-NTA Sepharose. The purified lyase had maximal activity (222 EU/mg) at pH 8 and... | 25,257,600 | [
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Impaired functional integration in multiple sclerosis: a graph theory study. | Aim of this study was to explore the topological organization of functional brain network connectivity in a large cohort of multiple sclerosis (MS) patients and to assess whether its disruption contributes to disease clinical manifestations. Graph theoretical analysis was applied to resting state fMRI data from 246 MS ... | 25,257,603 | [
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Low cytoplasmic pH reduces ER-Golgi trafficking and induces disassembly of the Golgi apparatus. | The Golgi apparatus was dramatically disassembled when cells were incubated in a low pH medium. The cis-Golgi disassembled quickly, extended tubules and spread to the periphery of cells within 30 min. In contrast, medial- and trans-Golgi were fragmented in significantly larger structures of smaller numbers at a slower ... | 25,257,606 | [
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Influence of treatments in multiple sclerosis disability: a cohort study. | A critical aspect of multiple sclerosis (MS) treatments is understanding the effect of disease-modifying drugs (DMDs) on the long-term risk of disability and whether the effect is related to disability at start of treatment. We performed an observational study on 3060 MS patients. The effect of therapy on progression t... | 25,257,611 | [
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Toward the use of proxy reports for estimating long-term patient-reported outcomes in multiple sclerosis. | Assessment of disease impact in multiple sclerosis (MS) is usually driven by information obtained directly from patients using patient-reported outcomes. However, when patients' response in longitudinal studies is less reliable or missing, proxy respondents may be used. The objective of this paper is to evaluate whethe... | 25,257,617 | [
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A theoretical study of the interaction of hydrogen and oxygen with palladium or gold adsorbed on pyridine-like nitrogen-doped graphene. | The interaction of H2 and O2 molecules in the presence of nitrogen-doped graphene decorated with either a palladium or gold atom was investigated by using density functional theory. It was found that two hydrogen molecules were adsorbed on the palladium atom. The interaction of these adsorbed hydrogen molecules with tw... | 25,257,619 | [
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Epigenetic mechanism causes Wnt9b deficiency and nonsyndromic cleft lip and palate in the A/WySn mouse strain. | The heritable multifactorial etiology of human nonsyndromic cleft lip with or without cleft palate (CL ± P) is not understood. CL ± P occurs in 15% of neonates in the homozygous A/WySn mouse strain, with a multifactorial genetic etiology, the clf1 and clf2 variant genes. Clf1 acts as a mutant allele of Wnt9b but its co... | 25,257,647 | [
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Variation and covariation in strongyle infection in East African shorthorn zebu calves. | Parasite burden varies widely between individuals within a population, and can covary with multiple aspects of individual phenotype. Here we investigate the sources of variation in faecal strongyle eggs counts, and its association with body weight and a suite of haematological measures, in a cohort of indigenous zebu c... | 25,257,652 | [
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Highly sensitive immunoassay for the diagnosis of acute myocardial infarction using silica spheres encapsulating a quantum dot layer. | Commercial ELISA kits for substance P (SubP), which are helpful for the clinical diagnosis of acute myocardial infarction, are limited in efficacy because of low sensitivity. A highly sensitive immunoassay was developed using silica spheres encapsulating a quantum dot-layer (SQS) and labeling antibodies, on a Parylene ... | 25,257,659 | [
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Targeting the cis-dimerization of LINGO-1 with low MW compounds affects its downstream signalling. | The transmembrane protein LINGO-1 is a negative regulator in the nervous system mainly affecting axonal regeneration, neuronal survival, oligodendrocyte differentiation and myelination. However, the molecular mechanisms regulating its functions are poorly understood. In the present study, we investigated the formation ... | 25,257,685 | [
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Parent Perceptions of Their Adolescent Athlete's Concussion: A Preliminary Retrospective Study. | Parent reports of their adolescent athletes' recovery from concussion are often considered by clinicians, but limited research has explored the factors (i.e., athletes' symptoms and neurocognitive performance) predicting parents' perceptions of athletes' recovery and how these factors relate to previous research on ath... | 25,257,693 | [
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Future development of biologically relevant dosimetry. | Proton and ion beams are radiotherapy modalities of increasing importance and interest. Because of the different biological dose response of these radiations as compared with high-energy photon beams, the current approach of treatment prescription is based on the product of the absorbed dose to water and a biological w... | 25,257,709 | [
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Clonal dissemination of multilocus sequence type 11 Klebsiella pneumoniae carbapenemase - producing K. pneumoniae in a Chinese teaching hospital. | Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae has disseminated rapidly in China. We aimed to analyze the molecular epidemiology of four KPC-producing K. pneumoniae strains isolated from a suspected clonal outbreak during a 3-month period and to track the dissemination of KPC-producing K. pneumonia r... | 25,257,726 | [
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The evolution of neurocritical care. | Although neurocritical care as a subspecialty is a relatively young field of medicine, its origins can be traced back to ancient times. This article focuses on the progression of neurocritical care from prehistoric trepanation procedures, through the development of mechanical ventilation, management of increased intrac... | 25,257,734 | [
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Brain death and management of a potential organ donor in the intensive care unit. | The concept of brain death developed with the advent of mechanical ventilation, and guidelines for determining brain death have been refined over time. Organ donation after brain death is a common source of transplant organs in Western countries. Early identification and notification of organ procurement organizations ... | 25,257,743 | [
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0.3033884,
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Regulation of CTR2 mRNA by the nonsense-mediated mRNA decay pathway. | The nonsense-mediated mRNA decay (NMD) pathway was originally identified as a pathway that degrades mRNAs with premature termination codons; however, NMD is now known to regulate natural mRNAs as well. Natural mRNAs are degraded by NMD due to the presence of specific NMD targeting features. An atypically long 3'-UTR is... | 25,257,758 | [
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0.... |
Medial patellofemoral ligament (MPFL) reconstruction improves radiographic measures of patella alta in children. | Patellofemoral instability has previously been associated with patella alta. The purpose of this study was to evaluate adolescents undergoing MPFL reconstruction for standardized indices of patellar height on pre- and post-operative radiographs to determine if these radiographic parameters change after MPFL reconstruct... | 25,257,777 | [
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Comparison between Elevate anterior/apical system and Perigee system in pelvic organ prolapse surgery: clinical and sonographic outcomes. | The aim of this study was to assess the incidence of de novo stress urinary incontinence (SUI) and sonographic features of implanted transvaginal mesh in continent women treated with Elevate(™) anterior/apical [single-incision mesh (SIM-A)] or Perigee(™) [transvaginal mesh with sacrospinous fixation (TVM + SSF)] in ext... | 25,257,810 | [
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Outcomes using a clinical practice pathway for the management of pulse loss following pediatric cardiac catheterization. | Objectives To describe the results of a clinical practice pathway (CPP) for the management of postcatheterization pulse loss in a children's hospital. Standardized approaches to the diagnosis and management of postcatheterization arterial thrombus are lacking. As a result, substantial practice variation exists. Data co... | 25,257,828 | [
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Altered ghrelin levels in boys with autism: a novel finding associated with hormonal dysregulation. | Autism is a neurodevelopmental disorder with unclear pathogenesis. Many clinical observations and hormone studies have suggested the involvement of the neuroprotective hormone ghrelin in autism. The current study aimed to investigate the potential role of ghrelin in autism and to elucidate the associated hormonal dysre... | 25,257,829 | [
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0.0... |
Lateral ventricle haemangioblastoma: the role of perfusion scanning and embolisation in diagnosis and management. | We present the case of a 24-year-old man who presented with vertigo and right-sided weakness. Subsequent imaging demonstrated a lateral ventricle haemangioblastoma. This is the first case ever to be treated with surgical excision augmented by preoperative endovascular embolisation, as illustrated with perfusion CT scan... | 25,257,888 | [
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Seizures and EEG features in 74 patients with genetic-dysmorphic syndromes. | Epilepsy is one of the most common findings in chromosome aberrations. Types of seizures and severity may significantly vary both between different conditions and within the same aberration. Hitherto specific seizures and EEG patterns are identified for only few syndromes. We studied 74 patients with defined genetic-dy... | 25,257,908 | [
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Clinical and immunochemical profiles of food challenge proven or anaphylactic shrimp allergy in tropical Singapore. | Shellfish allergy in Singapore is highly prevalent, and shrimp allergy is the most common. This study aims to evaluate the clinical characteristics and immunological phenotype of shellfish allergy in this population. Patients with self-reported shellfish allergy were recruited from outpatient clinics of three large hos... | 25,257,922 | [
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0.3610716,
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Topical therapy for toenail onychomycosis: an evidence-based review. | Managing toenail onychomycosis with topical treatments is challenging. It is difficult for topical medication to penetrate the nail plate, and this is reflected in lower cure rates with topical treatment than with oral treatment. However, oral medications may not be suitable for some patients, because of drug interacti... | 25,257,931 | [
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0.1974948,
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0... |
Attentional bias for pain- and period-related symptom words in healthy women who experienced a recent painful period. | Attentional biases for pain-related information have been commonly reported in patients with chronic pain. Biases may also exist in individuals who recently experienced an episode of acute clinical pain, although limited investigation has been conducted. The present study is the first to explore attentional biases in w... | 25,257,937 | [
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0.3267809,
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Clinical Profiles of Children with Disruptive Behaviors Based on the Severity of Their Conduct Problems, Callous-Unemotional Traits and Emotional Difficulties. | This study identified clinical profiles of referred children based on the severity of callous-unemotional (CU) traits, emotional difficulties, and conduct problems. Parents of 166 children (132 males) aged 6-12 years referred to a hospital clinic because of disruptive behavior completed measures to assess these key ind... | 25,257,946 | [
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Mendelian randomization of serum urate and parkinson disease progression. | Higher serum urate concentrations predict more favorable prognosis in individuals with Parkinson disease (PD). The purpose of this study was to test the causality of this association using a Mendelian randomization approach. The study was conducted among participants in DATATOP and PRECEPT, 2 randomized trials among pa... | 25,257,975 | [
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0.3763194,
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Individual differences in aversion to ambiguity regarding medical tests and treatments: association with cancer screening cognitions. | Aversion to "ambiguity"-uncertainty about the reliability, credibility, or adequacy of information-about medical tests and treatments is an important psychological response that varies among individuals, but little is known about its nature and extent. The purpose of this study was to examine how individual-level ambig... | 25,258,015 | [
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0.1519544,
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0.04456307,... |
Increased risk of severe congenital heart defects in offspring exposed to selective serotonin-reuptake inhibitors in early pregnancy--an epidemiological study using validated EUROCAT data. | Previous studies suggest a possible association between maternal use of selective serotonin-reuptake inhibitors (SSRIs) during early pregnancy and congenital heart defects (CHD). The purpose of this study was to verify this association by using validated data from the Danish EUROCAT Register, and secondary, to investig... | 25,258,023 | [
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0.3178329,
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0.3276706,
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0.0... |
Are physiotherapists reliable proxies for the recognition of pain in individuals with cerebral palsy? A cross sectional study. | Pain is an important problem for individuals with cerebral palsy (CP). In addition to pain associated to the pathology, individuals with CP are often exposed to physiotherapy procedures which may cause or relieve pain. The major aim of this study was to compare pain ratings self-reported by individuals with cerebral pa... | 25,258,089 | [
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Effect of selected Saccharomyces cerevisiae yeast strains and different aging techniques on the polysaccharide and polyphenolic composition and sensorial characteristics of Cabernet Sauvignon red wines. | The objective of this work was to study the effect of two Saccharomyces cerevisiae yeast strains with different capabilities of polysaccharide liberation during alcoholic fermentation in addition to subsequent aging on lees with or without oak wood chips as well as aging with commercial inactive dry yeast on the physic... | 25,258,103 | [
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0.3647479,
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Nickel(0)-catalyzed enantioselective annulations of alkynes and arylenoates enabled by a chiral NHC ligand: efficient access to cyclopentenones. | Cyclopentenones are versatile structural motifs of natural products as well as reactive synthetic intermediates. The nickel-catalyzed reductive [3+2] cycloaddition of α,β-unsaturated aromatic esters and alkynes constitutes an efficient method for their synthesis. Here, nickel(0) catalysts comprising a chiral bulky C1-s... | 25,258,104 | [
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... |
Early-stage minimally invasive procedures decrease perihematomal endothelin-1 levels and improve neurological functioning in a rabbit model of intracerebral hemorrhage. | To determine the effects of minimally invasive surgery (MIS) at various stages after intracerebral hemorrhage (ICH) on perihematomal endothelin (ET)-1 levels and neurological functioning. Sixty rabbits were randomly distributed into a model control group (MC group, 30 rabbits) or a MIS group (MI group, 30 rabbits). An ... | 25,258,111 | [
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Systematic implementation of evidence-based practice in a clinical nursing setting: a participatory action research project. | To describe the process of implementing evidence-based practice in a clinical nursing setting. Evidence-based practice has become a major issue in nursing, it is insufficiently integrated into daily practice and its implementation is complex. Participatory action research. The main participants were nurses working in a... | 25,258,116 | [
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Expression and purification of the trypsin inhibitor from tartary buckwheat in Pichia pastoris and its novel toxic effect on Mamestra brassicae larvae. | The gene of the trypsin inhibitor of tartary buckwheat (Fagopyrum tataricum) was successfully cloned, expressed in Pichia pastoris and tested for regulatory effects on insect growth. The three significant factors were optimized by single-factor experiments and central composite design in response surface methodology. P... | 25,258,121 | [
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Commitment to change and assessment of confidence: tools to inform the design and evaluation of interprofessional education. | This study examines use of the commitment-to-change model (CTC) and explores the role of confidence in evaluating change associated with participation in an interprofessional education (IPE) symposium. Participants included students, faculty, and practitioners in the health professions. Satisfaction with the symposium ... | 25,258,127 | [
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Training mid- to late-career health professionals for clinical work in low-income regions abroad. | Oregon Health & Science University (OHSU) Global Health Center has developed a unique training program-Professionals' Training in Global Health (PTGH)--for mid- and late-career health professionals wanting to perform clinical services overseas in low-income countries. A multidisciplinary, multifaceted, structured c... | 25,258,130 | [
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Assessing the impact of a medical librarian on identification of valid and actionable practice gaps for a continuing medical education committee. | Identifying educational needs related to professional practice gaps can be a complex process for continuing medical education (CME) committees and for physicians who submit activity applications. Medical librarians possess unique skills that may be useful for identifying practice gaps relevant to CME committees. We ass... | 25,258,131 | [
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The effect of modified ultrafiltration on angiopoietins in pediatric cardiothoracic operations. | Cardiopulmonary bypass subjects patients' blood to hemodilution and nonphysiologic conditions, resulting in a systemic inflammatory response. Modified ultrafiltration (MUF) counteracts hemodilution and has also been postulated to improve outcomes by proinflammatory cytokine removal. The objective of this study was to i... | 25,258,157 | [
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Preventing leptin resistance by blocking angiotensin II AT1 receptors in diet-induced obese rats. | AT1 receptor blockers (ARBs) represent an approach for treating metabolic syndrome due to their potency in reducing hypertension, body weight and onset of type 2 diabetes. The mechanism underlying ARB-induced weight loss is still unclear. Leptin resistance tests (LRTs) in diet-induced obese or lean rats were conducted ... | 25,258,168 | [
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Variable number tandem repeats in dopamine receptor D4 in Tourette's syndrome. | We attempted to clarify the association between dopamine receptor D4 (DRD4) 48-bp variable number of tandem repeats (VNTR) polymorphism and Tourette's syndrome. The DRD4 48-bp VNTR polymorphism was genotyped in 291 Tourette's syndrome patients (including 218 trios) and 405 controls. Chi-square and transmission disequil... | 25,258,183 | [
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Restoration of normal left ventricular geometry after percutaneous mitral annuloplasty: case report and review of literature. | Surgical mitral valve intervention is not considered suitable in patients with severe functional mitral regurgitation due to severe dilated cardiomyopathy and severe systolic dysfunction. In such patients percutaneous mitral valve intervention is the next best alternative. We are presenting case report of a patient who... | 25,258,184 | [
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Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells. | Arsenic trioxide is an old drug and has been used for a long time in traditional Chinese and Western medicines. However, the cancer treatment of arsenic trioxide has heart and vascular toxicity. The cytotoxic effects of arsenic trioxide and its molecular mechanism in human umbilical mesenchymal stem cells (HUMSC) and h... | 25,258,189 | [
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Methylmercury accumulation and elimination in mink (Neovison vison) hair and blood: results of a controlled feeding experiment using stable isotope tracers. | Concentrations of metals in hair are used often to develop pharmacokinetic models for both animals and humans. Although data on uptake are available, elimination kinetics are less well understood; stable isotope tracers provide an excellent tool for measuring uptake and elimination kinetics. In the present study, methy... | 25,258,205 | [
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Originator of feeding difficulty tool is made a fellow. | A NURSING professor who developed the only validated instrument for measuring feeding difficulty in dementia patients has been made a fellow of the Royal College of Physicians of Edinburgh. | 25,258,221 | [
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Practice Development Workbook for Nursing, Health and Social Care Teams Dewing Jan , McCormack Brendan , Titchen Angie Practice Development Workbook for Nursing, Health and Social Care Teams 248pp £29.99 Wiley Blackwell 9781118676707 111867670X [Formula: see text]. | WITH THE growth of practice development over the past 20 years there has been an increased understanding and focus on the importance of systematic, collaborative approaches, that lead to better outcomes for patients and their supporters. The pathways that individuals have followed as practice developers look and feel d... | 25,258,230 | [
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Listen, Talk, Connect: Communicating with People Living with Dementia Listen, Talk, Connect: Communicating with People Living with Dementia 68pp Care UK [Formula: see text]. | THIS BOOK is aimed at carers, relatives and friends of people living with dementia. It can be downloaded from Care UK's website at www.careuk.com/talk-dementia . It is excellent, attractively presented and easy to read. | 25,258,227 | [
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Noticeboard. | Courses, events, grants, and awards to progress your career. | 25,258,232 | [
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Progress towards early diagnosis of Alzheimer's disease. | Until recent years it was only possible to give a definitive diagnosis of Alzheimer's disease by post-mortem examination. In 2007, the International Working Group proposed that diagnosis could be made during the course of the disease. They suggested using clinical criteria such as poor memory that is not helped by givi... | 25,258,236 | [
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Embracing Empathy in Healthcare Bikker Annemieke P , Cotton Philip and Mercer Stewart W Embracing Empathy in Healthcare 144pp £32.99 Radcliffe 9781909368187 1909368180 [Formula: see text]. | PATIENTS AND carers expect to be engaged in a partnership with healthcare practitioners and wish to be informed about and involved in decisions. The hallmark of high quality care is responding effectively to the needs of each individual. The CARE approach is a framework for empathic, person-centred healthcare interacti... | 25,258,226 | [
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(Im)perishable Pleasure, (In)destructible Desire: Sexual Themes in U.S. and English News Coverage of Male Circumcision and Female Genital Cutting. | Under what conditions do sexual pleasure and desire get addressed in news coverage of sexual health issues like female genital cutting (FGC) and male circumcision (MC)? In this study we employed an embodied ethnosexuality approach to analyze sexual themes in 1,902 items published from 1985 to 2009 in 13 U.S. and 8 Engl... | 25,258,244 | [
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The effect of poly(methyl methacrylate) surface treatments on the adhesion of silicone-based resilient denture liners. | Different surface treatment protocols of poly(methyl methacrylate) have been proposed to improve the adhesion of silicone-based resilient denture liners to poly(methyl methacrylate) surfaces. The purpose of this study was to evaluate the effect of different poly(methyl methacrylate) surface treatments on the adhesion o... | 25,258,267 | [
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The effects of silane-SiO2 nanocomposite films on Candida albicans adhesion and the surface and physical properties of acrylic resin denture base material. | Polysiloxane has been used as a coupling material in restorative dental materials for several decades. However, few studies are available on the application of polysiloxane in other dental prosthesis functions. The purpose of this study was to investigate the effects of silane-SiO2 nanocomposite films on Candida albica... | 25,258,268 | [
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The Threat-Strategy Interview. | Operators in dynamic work environments use strategies to manage threats in order to achieve task goals. We introduce a structured interview method, the Threat-Strategy Interview (TSI), and an accompanying qualitative analysis to induce operator-level threats, strategies, and the cues that give rise to them. The TSI can... | 25,258,275 | [
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Sequential rhodium/palladium catalysis: enantioselective formation of dihydroquinolinones in the presence of achiral and chiral ligands. | Compatible combinations of achiral and chiral ligands can be used in rhodium/palladium catalysis to achieve highly enantioselective domino reactions. The difference in rates of catalysis and minimal effects of ligand interference confer control in the domino sequence. The "all-in-one" 1,4-conjugate arylation and C-N cr... | 25,258,276 | [
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Liquid chromatography tandem mass spectrometry method for the quantitative analysis of ceritinib in human plasma and its application to pharmacokinetic studies. | Ceritinib is a highly selective inhibitor of an important cancer target, anaplastic lymphoma kinase (ALK). Because it is an investigational compound, there is a need to develop a robust and reliable analytical method for its quantitative determination in human plasma. Here, we report the validation of a liquid chromato... | 25,258,279 | [
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Mitochondrial- and Fas-L-mediated pathways involved in quinestrol induced spermatogenic apoptosis in adult rat testes. | The pathways involved in quinestrol-induced spermatogenic apoptosis were studied in adult male rat by using daily intragastric administration of 0.01 mg/kg, 0.1 mg/kg and 1 mg/kg body weight quinestrol for two consecutive weeks. The immunohistochemistry staining was performed to measure the expression of proliferating ... | 25,258,304 | [
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Pre-computed system matrix calculation based on a piece-wise method for PET. | A system matrix (SM) is the basic component of iterative image reconstruction algorithms. Calculation of the SM needs a considerable amount of time due to an enormous number of lines of response (LORs) being modeled. In this study, we developed a technique based on a piece-wise calculation method in which symmetry and ... | 25,258,307 | [
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Motor deficits in children with autism spectrum disorder: a cross-syndrome study. | Recent research suggests that children with autism spectrum disorder (ASD) experience some level of motor difficulty, and that this may be associated with social communication skills. However, other studies show that children with language impairments, but without the social communication problems, are at risk of motor... | 25,258,309 | [
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Structure-function relationships in human testis-determining factor SRY: an aromatic buttress underlies the specific DNA-bending surface of a high mobility group (HMG) box. | Human testis determination is initiated by SRY, a Y-encoded architectural transcription factor. Mutations in SRY cause 46 XY gonadal dysgenesis with female somatic phenotype (Swyer syndrome) and confer a high risk of malignancy (gonadoblastoma). Such mutations cluster in the SRY high mobility group (HMG) box, a conserv... | 25,258,310 | [
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