title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Reduced sensitivity of the hepatic adenylate cyclase-cyclic AMP system to glucagon during sustained hormonal stimulation. | Hormone-induced desensitization of hormonal regulation of cyclic AMP (cAMP) content has been described in a number of tissues. In the present study, we examined responses of rat liver to glucagon after periods of sustained exposure to the hormone in vivo and in vitro. In intact anesthetized rats infused with glucagon (... | 176,180 | [
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Mechanism of activation adenylate cyclase in vitro by polymyxin-released, heat-labile enterotoxin of Escherichia coli. | Heat-labile enterotoxic material released from Escherichia coli by polymyxin B activates the adenylate cyclase of pigeon erythrocyte ghosts in a time- and concentration-dependent manner. The activation requires nicotinamide adenine dinucleotide, adenosine triphosphate, and another component of the erythrocyte supernata... | 176,279 | [
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Unilateral multiple tumours of the parotid gland. | The occurrence of two morphologically distinct tumors in a single parotid gland is rare. Pathologic examination of a unilateral parotid mass removed from a 63-year-old male revealed the presence of a benign mixed tumor and an adenolymphoma. No other examples of this relationship were encountered in the literature. | 176,288 | [
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Extracellular cyclic AMP-phosphodiesterase accelerates differentiation in Dictyostelium discoideum. | Extracellular cyclic AMP-phosphodiesterase accelerates the development of aggregation competence in Dictyostelium discoideum when present during the preaggregation stage. The effect on development appears to depend only on hydrolysis of extracellular cyclic AMP and not on other properties of the phosphodiesterase molec... | 176,311 | [
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Morphological correlates of synaptic transmission in lamprey spinal cord. | The dye Procion brown was used to identify in the light and electron microscope, synaptic contacts made between monosynaptically coupled neurons in the lamprey spinal cord whose synaptic interaction had been recorded. Synaptic contacts were made on different dendrites of the postsynaptic cell at different distances fro... | 176,330 | [
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Effect of LH on the release of cyclic AMP by the rabbit ovary perfused in vivo and in vitro. | After perfusion of 10 rabbit ovaries in vitro with a modified Krebs bicarbonate buffer containing dextran and glucose, the concentration of cAMP in the perfusion medium was significantly increased 2-5 min after stimulation with 10 mug LH/ml medium and was higher at 15 and 30 min. Intravenous injection of 100 mug LH/rab... | 176,357 | [
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Growth in semisolid agar medium of human cord leukocytes freshly transformed by Epstein-Barr virus. | The semisolid agar method for the selective growth of transformed cells was applied to investigations of Epstein-Barr virus (EBV) transformation. When 1 X 10(5) HUMAn umbilical-cord blood leukocytes were seeded in agar medium immediately after EBV exposure, about 100 colonies developed in each dish. The occurrence of ... | 176,377 | [
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Host-range properties of murine xenotropic and ecotropic type-C viruses. | Host-range properties of xenotropic (x-tropic) and ecotropic mouse type-C viruses were determined. NB-tropic viruses replicated only in mouse and rat cells, whereas x-tropic viruses, which do not exogenously infect mouse cells, grew in cells from various other mammalian species. Great variability in susceptibilities to... | 176,389 | [
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Effect of partial hepatectomy on tumor incidence and metabolism of mice fed thioacetamide. | Six-week-old male Swiss mice were given 0.03% thioacetamide (TAA) in the diet 24, 72, and 168 hours after partial hepatectomy. TAA-treated mice from all three groups were killed when they were 4, 9, and 13 months old. Intact and partially hepatectomized animals on normal diets served as controls. None of the controls e... | 176,394 | [
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Epstein-Barr virus in an American patient with Burkitt's lymphoma: detection of viral genome in tumor tissue and establishment of a tumor-derived cell line (NAB). | Epstein-Barr virus (EBV) DNA (17.7 genome equivalents/cell) was found in tumor tissue from an American patient with Burkitt's lymphoma who had never traveled outside the United States. A lymphoid cell line (NAB) containing the EBV genome was established from tumor tissue from this patient; characteristics of this cell ... | 176,407 | [
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Neoplastic transformation in tissues of rats exposed to monocrotaline or dehydroretronecine. | Male Sprague-Dawley rats received sc injections biweekly of either the pyrrolizidine alkaloid monocrotaline or its metabolite dehydroretronecine for 1 year. The animals were then observed for an additional 12 months for the induction of neoplasms. Of 60 rats that received dehydroretronecine, 39 developed rhabdomyosarco... | 176,409 | [
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Effect of phosphonoacetate on Marek's disease virus replication. | Phosphonoacetate (PA), but not any of its analogues tested, effectively inhibited avian herpesvirus replication and viral DNA synthesis in cell cultures. At 100 mug/ml culture medium, PA completely inhibited the replication of Marek's disease virus (MDV), herpesvirus of turkeys, and owl herpesvirus, but had no measurab... | 176,410 | [
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Rat sequences of the Kirsten and Harvey murine sarcoma virus genomes: nature, origin, and expression in rat tumor RNA. | Two murine sarcoma viruses, the Kirsten and the Harvey, were isolated by passage of mouse type C leukemia viruses through rats. These sarcoma viruses have genomes containing portions of their parental type C mouse leukemia virus genomes, in stable association with specific rat cellular sequences that we find to be quit... | 176,419 | [
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Effect of medium of lowered NaCl concentration on virus release and protein synthesis in cells infected with reticuloendotheliosis virus. | When cultures producing reticuloendotheliosis virus were incubated for 24 h in medium of lowered NaCl concentration, virus production was inhibited. The extent of inhibition increased as the salt concentration of the medium was decreased. The inhibition was rapidly reversed by replacement of low-salt medium with normal... | 176,425 | [
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Persistent reovirus infection of CHO cells resulting in virus resistance. | We obtained a persistently infected line of Chinese hamster ovary cells by selection for resistance to reovirus infection. The cells were persistently infected by a population of viruses that were (i) cytopathic for parental chinese hamster ovary cells and (ii) similar to wild-type reovirus in molecular characteristics... | 176,428 | [
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Genomic complexities of murine leukemia and sarcoma, reticuloendotheliosis, and visna viruses. | The genetic complexities of several ribodeoxyviruses were measured by quantitative analysis of unique RNase T1-resistant oligonucleotides from 60-70S viral RNAs. Moloney murine leukemia virus was found to have an RNA complexity of 3.5 x 10(6) daltons, whereas Moloney murine sarcoma virus had a significantly smaller gen... | 176,429 | [
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Hydrodynamic diameters of murine mammary, Rous sarcoma, and feline leukemia RNA tumor viruses: studies by laser beat frequency light-scattering spectroscopy and electron microscopy. | We have studied purified preparations of murine mammary tumor virus (MuMTV), Rous sarcoma virus (RSV; Prague strain), and feline leukemia virus (FeLV) by laser beat frequency light-scattering spectroscopy, ultra-centrifugation, and electron microscopy. The laser beat frequency light-scattering spectroscopy measurements... | 176,431 | [
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Kinetics of utilization of Sendai virus RNA and protein in the process of virion assembly. | The synthesis of the 50S genomic RNA and strucural proteins of Sendai virus was examined with respect to their utilization in virus assembly. It was found that during a single cycle of infection, 50S RNA was synthesized before the structural proteins and that both RNA and protein were synthesized 2 to 4 h before their ... | 176,433 | [
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Regulatory mechanism of simian virus 40 gene expression in permissive and in nonpermissive cells. | Primary or continuous lines of mouse cells (3T3) are nonpermissive for simian virus 40 (SV40). Abortively infected cells synthesize tumor antigen (T antigen but not viral DNA and virus capsid protein (V antigen). V antigen, however, was obtained when SV40 DNA was injected into 3T3 cells. This late gene expression also ... | 176,449 | [
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Analysis of structural proteins of purified murine cytomegalovirus. | Murine cytomegalovirus propagated in mouse embryo fibroblasts was purified by the following procedures. (i) Extracellular virus was concentrated by centrifugation at 100,000 x g for 90 min. (ii) The concentrated virus was passed through a Bio-Rad Bio-Gel A-15m column to eliminate contaminating materials smaller than 15... | 176,450 | [
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Membrane proteins specified by herpes simplex viruses. I. Identification of four glycoprotein precursors and their products in type 1-infected cells. | Polypeptide precursors to the major glycoproteins specified by herpes simplex virus type 1 were identified in immunoprecipitation experiments using antisera that reacted specifically with the viral glycoproteins and their precursors. The results demonstrate that the major glycosylated proteins detected in infected cell... | 176,453 | [
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Chemical modification of simian virus 40 DNA by reaction with a water-soluble carbodiimide. | Superhelical simian virus 40 (SV40) DNA I can be modified with N-cyclohexyl-N'-beta-(4 methylmorpholinium)ethylcarbodiimide (CMC). The reaction produces an increase in the sedimentation velocity of DNA I from 21 to 22.5S and a decrease in its buoyant density in CsCl from 1.694 to 1.688. A comparable shift in buoyant de... | 176,461 | [
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Cell killing by simian virus 40: variation in the pattern of lysosomal enzyme release, cellular enzyme release, and cell death during productive infection of normal and simian virus 40-transformed simian cell lines. | Simian virus 40 (SV40) growth on rhesus kidney cells and on the T-22 line of SV40-transformed green monkey kidney (GMK) cells is largely limited by the low plating efficiency of SV40 on these cells. In addition, a fraction of the rhesus kidney and T-22 cells are resistant to infection by SV40. Nevertheless, 72-h viral ... | 176,470 | [
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Antigenic activity of human urothelial tissue. | Partially purified extracts from 71 human urothelial tumors and from 75 human urothelial non-tumor tissues were used as competing antigens in competition radioimmunoassay in an effort to detect the presence of 1 of the structural components of type C-ribonucleic and viruses, the p30 core protein. Testing of the tissue ... | 176,474 | [
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MBK neuropathy among spray painters. | It has been suggested that the solvent methyl N-butyl ketone (MBK) may cause peripheral neuropathy in humans. An investigation was undertaken after two cases of peripheral neuropathy among spray painters at one work site were reported to the National Institute for Occupational Safety and Health. Twenty-six painters wer... | 176,479 | [
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[Diurnal profiles of plasma aldosterone, cortisol, renin, angiotensinogen and angiotensinases in normal subjects (author's transl)]. | Plasma cortisol and renin were estimated in 1 h intervals, plasma aldosterone, angiotensinogen and angiotensinases in 3 h intervals over periods of 24 h in six normal volunteers (age 20-26) under control conditions and subsequently under suppression of ACTH release by dexamethasone. Highest cortisol levels were found a... | 176,503 | [
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The effect of transformation-defective avian oncornavirus mutants on tumor antigen expression. | The recent isolation of conditional (temperature sensitive) and nonconditional transformation-defective mutants of avian sarcoma virus strains has facilitated the investigation of the effect of virus transformation on the cell's phenotype, e.g., with respect to morphology, growth pattern, or cell surface antigenicity. ... | 176,534 | [
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Juvenile nasopharyngeal angiofibroma: radiographic aspects. | Because of consistent and unique radiographic features of JNA, it is not necessary, nor is it advisable, to biopsy these tumors to establish a diagnosis. In addition, the carotid arteriograms show the major feeding vessels to the lesion and also completely delineate the periphery of the tumor, thus establishing operabi... | 176,543 | [
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[Angiographic findings of tentorial branches of the internal carotid artery in gliomas infiltrating the tentorium (author's transl)]. | The tentorial branches, originating from the cavernous portion of the internal carotid artery, showed pathological findings in two cases of brain tumors infiltrating the tentorium: a glioblastoma multiforme of the temporooccipital and basal regions and a medulloblastoma diffusely involving the cerebellar hemisphere, ve... | 176,605 | [
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The relationship between the rate of rise of isometric tension and motor unit recruitment in a human forearm muscle. | The recruitment properties of single motor units from the human extensor indicis muscle were investigated during voluntary isometric contractions of different rate of rise but equal amplitude. Both the electrical and the contractile events associated with recruitment were analyzed. The threshold force of recruitment (m... | 176,624 | [
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[Leucaemoid reaction due to cytomegalovirus infection in a new born infant (author's transl)]. | A newborn infant with low birth weight, jaundice, petechiae of the skin and enlargement of spleen and liver is presented. His general condition was severe and progressive aggravation of it was noticed. Bilirubin levels was up to 44 mg/100 ml, most of it indirect and severe anaemia was present. Furthermore leucaemoid re... | 176,629 | [
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Thyrotropin-ganglioside interactions and their relationship to the structure and function of thyrotropin receptors. | Gangliosides inhibit 125I-labeled thyrotropin binding to the thyrotropin receptors on bovine thyroid plasma membranes, on guinea pig retro-orbital tissue plasma membranes, and on human adipocyte membranes. This inhibition by gangliosides is critically altered by the number and location of the sialic acid residues withi... | 176,657 | [
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[Malignant synovialoma (author's transl)]. | Based upon 351 cases of malignant synovialoma from the literature and 12 own observations clinical and roentgenographic findings, differential diagnosis, therapy, and prognosis are discussed. Because of early recurrencies and metastases early diagnosis is most important for therapeutic results. By means of radical surg... | 176,684 | [
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REM sleep induction by physostigmine infusion during sleep. | Physostigmine (an anticholinesterase agent that increases acetylcholine at the synapse), in a dose of 0.5 milligram, was given intravenously to seven normal human volunteers. When injected during rapid eye movement (REM) sleep, physostigmine woke the subjects, and when injected during non-REM sleep, it induced REM slee... | 176,724 | [
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[A propos of 210 emergency endoscopies in upper digestive hemorrhage]. | The authors report their experience of 210 fiber endoscopies carried out as an emergency for upper digestive hemorrhage. They emphasize the necessity of early examination and only consider here examinations carried out within 12 hours from the start of the hemorrhage. In 91.4 % of cases, a correct diagnosis was possibl... | 176,729 | [
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[Routine gastric fiber endoscopy in severe head injuries]. | Gastric lesions in severe cranial trauma are almost constant, whether the patients have bled or not. Routine fiber endoscopy in 63 cases permited the authors to discover various types of lesion, some in association, whether diffuse or localised, e.g. oedema or congestion, viz. congestion, purpura, various sized ulcers,... | 176,731 | [
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0.002... |
[Intermittent thrombolytic treatment. Results during severe, chronic arterial diseases]. | 38 patients with severe chronic arteritis of the lower limbs were treated with streptokinase intermittently. All had been refused for surgical operation. One patient died, 4 others had early interruption of treatment. Eleven of the 38 patients had efficient thrombolysis confirmed by arteriography. The facts confirm the... | 176,733 | [
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Ascorbate inhibition of 6-aminonicotinamide teratogenesis in chicken embryos. | Chicken eggs of 4 or 6 days of incubation were injected with 10 mug 6-aminonicotinamide (6-AN) or 6-AN plus various doses of sodium ascorbate, calcium ascorbate, or ascorbic acid; 11-day embryos were examined grossly and histologically. 6-AN-treated embryos had various degrees of micromelia and were reduced in overall ... | 176,744 | [
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Effect of chilling on platelet cyclic adenosine 3:5-monophosphate and adenylate cyclase activity. | Exposure of platelets to 1 C led to a transient increase in cyclic AMP levels (determined either by a protein binding method or by radioimmunoassay) within five to ten minutes reaching a maximum 10 to 15 minutes after chilling was begun and returning subsequently to baseline values. Addition of EDTA to the platelet sus... | 176,753 | [
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... |
[Reduction of oily substances in rabbit lungs (author's transl)]. | Artificial fat embolism in rabbits was caused by injection of olive oil and Lipiodol Ultrafluid into the ear vein. Electron-microscopic and histochemical observations of the lung were made. The content of nonspecific esterase was evaluated. Serious defects of blood vessels and pneumocytes as well as an increase in alve... | 176,773 | [
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Concentric nuclear inclusions. | Membrane bound concentric lamellar inclusions were found in the nuclei of pancreatic acinar cells of a patient with multiple primary neoplasms and in the parotid acinar cells of a patient with systemic lupus erythematosus. It is proposed that these inclusions form from rough cisternae sequestered in the nucleus. | 176,776 | [
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[The potentiating effects of azathioprine and azapropazone on the enzyme activity in experimental inflammation]. | The influence of prednisolone, azathioprine, and azapropazone on the activity of collagen peptidase, acid phosphatase (complete), and the lactate dehydrogenase of granulation tissue was studied using a model of proliferative inflammation i.e. the cotton-granuloma in rats. The authors observed significant decreases in t... | 176,844 | [
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Utilization of dehydroepiandrosterone and its sulphate for oestrogen production by pregnant baboons (Papio papio). | The effect of varying maternal circulating 3beta-hydroxy-5-androsten-17-one (D) and its sulphate (DS) on urinary oestrogen (Oe) excretion by baboons was determined between 65 and 174 days gestation (term = 184 days). Oe (mainly oestrone) was determined by radioimmunoassay after enzymic hydrolysis of conjugates. Increme... | 176,856 | [
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Effects of viral and mycoplasma infections on ultrastructure and enzyme activities in human skeletal muscle. | The effect on skeletal muscle of acute viral and mycoplasma infections in thirteen men of ages ranging between 20-42 years has been studied. Comparisons are made with eight healthy men in the age group 22-29 years who were confined to bed for periods of time of lengths similar to the confinement to bed of the patients.... | 176,868 | [
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Biosynthesis of unsaturated fatty acids in cultured minimal deviations hepatoma 7288 C cells. | Minimal Deviation Hepatoma 7288 C cells were cultured in confluent layer with labeled linoleic, alpha-linolenic, eicosa-8,11,14-trienoic and stearic acids. The cells in culture preserved their ability to convert stearic acid to oleic acid. They also synthesized arachidonic acid from linoleic acid or eicosa-8,11,14-trie... | 176,870 | [
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Phosphopyridoxal complexes with histamine and histidine. (4) The kinetics of complex formation between histidine and pyridoxal 5' -phosphate in the presence of bacterial histidine decarboxylase. | The dynamics of the complex formation between pyridoxal 5'-phosphate (PLP) and histidine in the presence of bacterial histidine decarboxylase was examined. Since PLP is able to form a cyclic product with histidine and histamine, the possibility of complex formation between PLP and histamine formed during a decarboxylat... | 176,880 | [
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Case report. Clostridium perfringens septicemia with detection of phospholipase C activity in the serum. | Clostridium perfringens septicemia with massive hemolysis is described in an elderly woman with refractory anemia. This case is highly unusual in that (1) the diagnosis was made during life by discovery of the organisms on a routine peripheral blood film, and that (2) phospholipase C activity was detected in the serum. | 176,888 | [
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The value of arteriography in the diagnosis and treatment of insulinomas. | Six arteriograms were performed in five patients with insulinoma. The method showed with precision the size and location of the tumor in five instances, whereas in one instance the method was unsuccessful. Arteriography was performed again with more refinements in technic, but was adequate in locating only the largest ... | 176,896 | [
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Infiltrating ductal carcinoma of the breast in the postpubertal adolescent: a case report. | Infiltrating ductal carcinoma is an extremely rare neoplasm in the teenage or pre-teenage child. Routine pediatric physical examination should include careful examination of the breast and all palpable masses should be excised. Carcinoma occurring in the prepubertal child carries an improved prognosis particularly if t... | 176,911 | [
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Role of ionophores in energy coupling. | If, as we deem inevitable, the principles of energy coupling are universal, then the necessity for charge-separating devices will apply across the board to all bioenergetic systems. Since, apart from the elctron transfer chain, ionophores are the only charge-separating devices available in bioenergetic systems, model o... | 176,915 | [
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Inhibition of herpesvirus deoxyribonucleic acid and protein synthesis by tilorone hydrochloride. | Tilorone hydrochloride at a concentration of 10 mug/ml very efficiently inhibited herpes simplex virus growth in BSC1 cells when the virus is infected at a low multiplicity of infection. The adsorption of the virus was not affected by the drug, and the penetration of the deoxyribonucleic acid of the input virus into th... | 176,928 | [
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Inhibition of Clostridium perfringens by an antibiotic substance produced by Bacillus licheniformis in the digestive tract of gnotobiotic mice: effect on other bacteria from the digestive tract. | A strain of Bacillus licheniformis, established in the digestive tract of gnotobiotic mice, inhibited the subsequent establishment of a Clostridium perfringens strain ingested by the animals. This inhibitory effect depended on the in vivo production by B. licheniformis of an antibiotic substance having a number of the ... | 176,929 | [
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Use of sodium polyanethol sulfonate to selectively inhibit aminoglycoside and polymyxin antibiotics in a rapid blood level antibiotic assay. | Sodium polyanethol sulfonate inhibits aminoglycoside and polymyxin classes of antibiotics in direct proportion to its concentration. Aminoglycoside and polymyxin class antibiotics are selectively inactivated; penicillin, including the semisynthetic penicillins, cephalothin, chloramphenicol, clindamycin, tetracycline, e... | 176,933 | [
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In vitro susceptibility of varicella zoster virus to adenine arabinoside and hypoxanthine arabinoside. | The in vitro susceptibility of varicella zoster (VZ) isolates to adenine arabinoside (ara-A) and hypoxanthine arabinoside (ara-Hx) was determined in human skin fibroblasts. Using a system in which deamination was inhibited, and using a modified plaque reduction method, the antiviral activities of ara-A and ara-Hx were ... | 176,937 | [
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0.1293625,
-0.241982... |
Benign liver cell adenoma associated with use of oral contraceptive agents. | A benign hepatic adenoma in a young woman taking oral contraceptives for 7 years is reported. The diagnosis must be suspected in any young woman taking oral contraceptive agents who develop signs and symptoms of acute cholecystitis with hepatomegaly or mass, or when signs and symptoms of non-traumatic intraabdominal he... | 176,959 | [
-0.2884026,
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0.2586619,
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0.1916592,
0.1647738,
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... |
Cystosarcoma phyllodes metastatic to a brenner tumor of the ovary. | A patient had cytosarcoma phyllodes that developed metastases to bone and to a Brenner tumor of the ovary. The original breast tumor was reported as benign, but the patient died of metastases four months following mastectomy. The rapid growth in the ovary may have been due to estrogenic stroma in the Brenner tumor. Thi... | 176,963 | [
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0.01960517,
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0.3648462,
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0.3862482,
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0.2970569,
0.05784277,
-0.3155269,... |
[Study of cortico-melanotropic activities in the anterior pituitary of an anencephalic and a normal newborn]. | Immunofluorescence studies by-means of anti-beta (1-24) corticotropin, anti-alpha (17-39) ACTH; anti-beta-MSH were performed on the anterior pituitary of an at-term anencephalic newborn. They showed small and rare cortico-melanotropic cells, as compared to those seen in the anterior pituitary of newborns. The compariso... | 176,960 | [
0.06217949,
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0.4212425,
0.4610023,
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0.0... |
[Morphofunctional state of pulmonary macrophages and their biological protection during phagocytosis of toxic elements]. | Studies of a morphofunctional state of macrophages of the lungs of rats in phagocytosis of quartz (size of particles 1-2 mum) and against the background of prophylactic administration of polyvinylridine-N-oxyde (PVNO) were carried out using the method of quantitative cytochemistry (interference microscopy and cytometry... | 176,981 | [
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0.03920361,
0.006104342,
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0.03148393,
0.359141,
0.373132,
0.06712312,
0.3920986,
0.04408139,
0.09... |
Neurologic manifestations of glomus tumors in the head and neck. | In 75 patients with glomus tumors in the head and neck region, 57 tumors arose from the jugular bulb region, 11 from the middle ear, and seven from the vagus nerve. Thirty-seven percent (28 patients) had cranial nerve paralysis, and 14.6% (11) had intracranial tumor extension. The jugular foramen syndrome was associate... | 176,982 | [
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0.2694973,
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0.2933338,
0.1447886,
0.1666031,
0... |
The oncogenic potential of some avian adenoviruses causing diseases in chickens. | The oncogenic potentials of three different strains of avian adenoviruses (the Tipton strain of the inclusion body hepatitis virus, the DPI-2, and the Indiana C viruses) were investigated in newborn hamsters. Animal inoculations were via two routes, subcutaneous and intracerebral. All three viruses proved nononcogenic ... | 176,986 | [
-0.4123921,
0.05384495,
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0.1391847,
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0.1783545,
0.07567938,
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0.3930424,
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0.160528,
0.2926439,
0.01984073,
... |
Expression of the human adenylate kinase isozymes, phosphopyruvate hydratase, 6-phosphogluconate dehydrogenase, and phosphoglucomutase-1 in man-rodent somatic cell hybrids. | The expression of the adenylate kinase isozymes and of phosphopyruvate hydratase was studied in man-mouse and man-hamster hybrid clones. Concordant segregation of the loci coding for AK-2 and PPH was observed in 54 of 55 primary hybrid clones, and these loci were demonstrated to be synthetic with the loci specifying PG... | 176,998 | [
-0.1521906,
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-0.3113176,
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0.123268,
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0.2470467,
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0.5544515,
0.02444437,
-0.121925,
... |
Regulation of mitochondrial protein turnover by thyroid hormone(s). | 1. The effect of thyroidectomy on turnover rates of liver, kidney and brain mitochondrial proteins was examined. 2. In the euthyroid state, liver and kidney mitochondria show a synchronous turnover with all protein components showing more or less identical half-lives compared with the whole mitochondria. The brain mito... | 177,002 | [
-0.1692973,
0.05275917,
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0.1004534,
0.2321195,
0.1735756,
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-0.3848228,
0.22... |
Analysis of metabolic changes in revertants of antibiotic-resistant micobacteria. | In the present report evaluation of the possible metabolic changes in partially revertants of M. tuberculosis var. hominis, reisolated from strains at high levels of drug-resistance after treatment with mutagenic agents, was reported. Based on the data presented here, it must be concluded that no significant biological... | 177,028 | [
-0.09828975,
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0.01367551,
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0.2479014,
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0.07593351,
0.2102716,
0.2969996,
0.1426869,
0.194628,
-0.154964,
-0... |
On the use of the spin labeling technique in the study of erythrocyte membranes. | ESR spectra and scanning electron micrographs of human erythrocytes spin labeled with the conventional stearic acid nitroxide substituted at the 5-position have been obtained over a range of label-to-lipid ratios. While morphological changes as previously reported (Bieri, V. G., Wallach, D. F. H. and Lin, P. S. (1974) ... | 177,059 | [
0.001158642,
0.2009378,
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0.006290003,
0.2186613,
0.08029478,
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0.009321542,
0.2259992,
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0.1175603,
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0.1708016,
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0.1419801,
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0.2488987,
0.3667676,
0.6108989,
0.1616954,... |
[Autoradiographic study of human scirrhous gastric carcinoma during cultivation in diffusion chambers]. | The growth of the epithelial and connective tissue cells was noted in cultivation of human schirrous carcinoma of the stomach in diffuse chambers. In difference to the initial tissue of the tumour in vitro in which no incorporation of thymidine-H3 into the connective tissue cells was noted, these cells proved to be lab... | 177,125 | [
0.03999965,
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0.3596764,
0.611053,
0.1311945,
-0.05778884,
... |
In vitro colony-forming cells in the marrow of leukemic and preleukemic mice. | In vitro colony-forming cells (CFUc) were evaluated in preleukemic and leukemic AK mice. Increased concentrations of CFUc were found in normal appearing marrow of superinfected animals 2-3 wk prior to the onset of lymphoma. CFUc were present in marrows of mice with virus-accelerated, spontaneous, and transplanted lymph... | 177,133 | [
-0.06374031,
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0.3766203,
0.2173538,
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0.07876523,
... |
The effects of long term feeding of Solanum glaucophyllum to growing rats on Ca, Mg, P and bone metabolism. | The effects of the long term ingestion of Solanum Glaucophyllum leaves (SG) by the rat was investigated in two series of experiments; the animals were fed a normal (for 8 weeks) or a low Ca diet (for 5 weeks). With both diets, the intestinal absorption of Ca was increased and the endogenous fecal Ca excretion was decre... | 177,152 | [
-0.1032571,
0.184041,
-0.06170904,
0.04893843,
-0.02631064,
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0.05154984,
0.2243549,
0.05546109,
0.3588085,
0.0218738... |
Comparative ultrastructure of selected oral streptococci: thin-sectioning and freeze-etching studies. | The ultrastructure of Streptococcus mutans, serotypes a-e, S. sanguis, S. mitis, and S. salivarius HHT, were examined by the techniques of thin-sectioning and freeze-etching. The cell walls varied in width between 15 and 46 nm and were covered with an electron-dense fibrillar or fuzz layer. The cytoplasmic membrane was... | 177,163 | [
0.06130605,
0.2917367,
0.0274766,
0.1934756,
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0.2836921,
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-0.09948654,
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-0.02251883,
0.9675714,
-0.1991157,
-0.2073742... |
Primary intracranial Burkitt's lymphoma in an infant. | A case of intracranial Burkitt's lymphoma is reported in a child whose symptoms began at 3 months of age with a definite histologic diagnosis established at 18 months. Serologic studies demonstrated high antibody titers to Epstein-Barr virus (EBV) in the patient and in four out of five members of the immediate family. ... | 177,169 | [
-0.118216,
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-0.2993368,
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0.09232151,
0.3858531,
0.1230914,
0.04560303,
-... |
Mediastinoscopy: a diagnostic aid in metastatic carcinoma of the breast. | Six patients with metastatic carcinoma of the breast underwent mediastinoscopy to obtain tissue for estrogen receptor analysis and pathologic confirmation of metastatic tumor. The indication for mediastioxcopy was an abnormal mediastinal accumulation of gallium in five patients, only two of whom had an abnormality note... | 177,183 | [
0.0480414,
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0.557156,
0.22542,
0.1514031,
... |
Hepatocellular carcinoma in the Malaysian Orang Asli. | Necropsies were performed on 285 consecutively unclaimed Orang Asli bodies from Gombak Orang Asli Hospital during an eight-year period from May 1967 to April 1975. Of the 25 malignant neoplasms, hepatocellular carcinoma was by far the commonest (36%). The nine patients with this neoplasm had coexistant macronodular cir... | 177,187 | [
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0.1907811,
0.1581949,
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0.06515209,
0.2805735,
-0.02459045,... |
Alanosine toxicity in Novikoff rat hepatoma cells due to inhibition of the conversion of inosine monophosphate to adenosine monophosphate. | 2-Amino-3-(hydroxynitrosoamino)propionic acid (alanosine), at a concentration as low as 2.7 muM, completely inhibits the incorporation of hypoxanthine into adenosine triphosphate by cultured Novikoff rat hepatoma cells. Alanosine inhibits the first step in the conversion of inosine monophosphate to adenosine monophosph... | 177,207 | [
-0.3189993,
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-0.6630142,
0.004499325,
0.6690452,
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0.1221694,
0.4993794,
0.09716238,
-0.0553282... |
Vincristine (NSC-67574) in the treatment of small-cell anaplastic carcinoma of the lung. | In a phase II trial the effect of vincristine as a single agent was evaluated in patients with small-cell anaplastic carcinoma of the lung. The dosage of vincristine was 1.5 mg/m2/week given iv for 4 weeks, followed by 1.5 mg/m2 given every other week with dose modifications according to neurologic tolerance. Nineteen ... | 177,209 | [
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0.2628312,
0.1261021,
0.09065356,
0.1033155,... |
[The mode of action of bacteriocin N5 purified from Clostridium perfringens]. | The purified bacteriocin N5 produced by Clostridium perfringens BP6K inhibited simultaneously the syntheses of DNA, RNA and protein in sensitive cells, without DNA degradation. Bacteriocin N5 inhibited the accumulation of leucin and caused the exit of the previously accumulated amino acid. The effects of bacteriocin N5... | 177,225 | [
-0.1295781,
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0.0256362,
0.3470323,
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-0... |
Increased serum calcitonin levels in bronchogenic cancer. | A study of 26 men with bronchogenic cancer demonstrated high serum calcitonin levels in 62 percent (16). Levels were particularly high in patients with small-cell cancer and adenocarcinoma. Two varieties of hypercalcitonemia have been encountered: (1) ectopic hypercalcitonemia, in which the hormone is secreted by the t... | 177,250 | [
-0.2258179,
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0.267397,
0.1462698,
-0.1538559,
... |
[Ultrastructure of the lymphocytic nucleus under the effect of phytohemagglutinin stimulation]. | The author presents a review of the literature, in which he describes the blast transformation of lymphocytes, induced by lectines, as a proper model for examining the metabolic and connected with them morphological changes in cellular activation. The literature connected with the basic achievements in examining the ul... | 177,261 | [
0.0716645,
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0.6097163,
0.05810921,
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Basal and dibutyryl cyclic AMP-stimulated release of newly synthesized and stored growth hormone from perifused rat pituitaries. | The basal rate of pre-labeled stored 14C-labeled rat growth hormone ([14C]rGH) release from perifused rat pituitary explants is a constant fraction of pituitary GH content, suggesting random release from the storage pool. Basal release of newly synthesized [3H]rGH occurs in two phases: 1) immediate and associated with ... | 177,264 | [
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0.1751746,
0.4146065,
0.3569787,
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... |
Dog thyroid cells in monolayer tissue culture: adenosine 3', 5'-cyclic monophosphate response to thyrotropic hormone. | A simple, rapid, and efficient method is described for establishing dog thyroid cells in tissue culture. Thyroid cell yield from a small amount of tissue (1 g) is high and viability is excellent. The adenosine 3',5-cyclic monophosphate (cAMP) response to thyrotropin (TSH) was investigated in these thyroid cells. Peak c... | 177,275 | [
-0.05719258,
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-0.1174485,
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0.1216648,
0.6219765,
-0.064753,
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... |
Metabolism of very low density lipoproteins in hyperlipidaemia: studies of apolipoprotein B kinetics in man. | The metabolism of very low density lipoprotein-B (VLDL-B) peptide was studied in nineteen subjects with endogenous hypertriglyceridaemia (Types V, IV and IIb), three patients with heterozygous familial hyperbetalipoproteinaemia (Type IIa) and eight healthy subjects, by reinjecting autologous radioiodinated VLDL. The ki... | 177,296 | [
0.01538457,
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0.2284917,
0.3583598,
0.3876671,
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... |
Central dopaminergic neurons: effects of alterations in impulse flow on the accumulation of dihydroxyphenylacetic acid. | Stimulation of the nigro-neostriatal or mesolimbic dopamine pathway results in a stimulus dependent increase in the accumulation of dihydroxyphenylacetic acid (DOPAC) in the neostriatum and olfactory tubercles, respectively. A block of impulse flow induced pharamacologically by administration of gamma-butyrolactone or ... | 177,297 | [
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0.2577313,
0.3475967,
0.09430034,
0.3244836,
0.2058923,... |
[Epidemiology of human and animal brucellosis in western Africa. The results of six studies in the Ivory Coast, Upper Volta, and Nigeria]. | Brucellosis has a two-fold importance in public health: the transmission of the disease to man by contact with animals or ingestion of raw milk is of direct importance; of indirect importance is the loss of animal protein. The authors have carried out ten epidemiological investigations in different bio-climatic zones o... | 177,324 | [
0.1186533,
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-0.02392,
-0.0... |
Institutional dependence is reversible. | A project is described whereby in 12 months, 105 long-stay psychiatric patients were able to be discharged to the homes of private individuals to become members of a 'family', to whom they were not related. The task necessitated a change in attitudes of the whole hospital staff--as resistance to change was encountered ... | 177,334 | [
0.0154082,
0.02197355,
0.0691075,
0.08727379,
0.2971992,
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0.3067461,
0.04449244,
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0.2634445,
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0.1045175,
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0.2294257,
0.1001318,
-... |
Quantitation of estradiol receptors employing a sensitive radioimmunoassay. | A method aimed at the identification and quantitation of estradiol receptors has been developed. The test is based on competitive binding reaction between solubilized cell receptors and anti-estradiol antibodies bound to acrylamide beads, for 3H-estradiol. The technique can be employed both for estradiol radioimmunoass... | 177,356 | [
0.06636521,
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0.1200761,
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0.1648174,
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0.2747504,
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0.1931366,
0.4967696,
0.01732497,
-0.06433666,... |
Use of cryopreserved virus-infected target cells in a lymphocytotoxicity 51Cr release microassay for cell-mediated immunity to cytomegalovirus. | A new 51Cr-release microassay is described for the measurement of cell-mediated immunity to cytomegalovirus, using cryopreserved target cells acutely infected with cytomegalovirus. | 177,371 | [
-0.3293305,
-0.1935453,
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0.1189369,
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-0.04009434,
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0.5650049,
0.1831589,
0.2282025,
0.06653287,
0.1038... |
Plasmid-determined alcohol dehydrogenase activity in alkane-utilizing strains of Pseudomonas putida. | We have identified an alcohol dehydrogenase activity in Pseudomonas putida strains carrying the CAM-OCT degradative plasmid that were grown on octane. The activity is nicotinamide adenine dinucleotide independent, sediments at 48,000 x g, and shows 20-fold greater activity with octanol rather than butanol as substrate.... | 177,405 | [
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0.02667099,
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0.162648,
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0.2801808,
0.30707,
0.1712914,
0.2693431,
0.1781423,
-0.2346411,
0.297618... |
Nuclear magnetic relaxation studies of the conformation of adenosine 5'-triphosphate on pyruvate kinase from rabbit muscle. | The conformation of adenosine 5'-triphosphate in the manganese complex of pyruvate kinase from rabbit muscle was determined from six metal to nucleus distances derived by nuclear magnetic relaxation techniques. On the enzyme, no direct metal-ATP coordination exists. The phosphorous atoms of ATP are 4.9 to 5.1 A away fr... | 177,414 | [
-0.1505658,
0.2609992,
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0.1183093,
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0.09917206,
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0.01013524,
0.565267,
0.0202662,
-0.1295905,
... |
The reduced nicotinamide adenine dinucleotide-activated phosphoenolpyruvate carboxylase from Pseudomonas MA. Correlation of allosteric properties with changes in the sedimentation behavior. | Phosphoenolpyruvate carboxylase from Pseudomonas MA, grown on methylamine as a sole carbon source, has been studied with respect to some of its regulatory properties. The enzyme shows both negative and positive cooperativity with respect to the substrate phosphoenolpyruvate (Hill coefficients of 0.5 and 1.75). The enzy... | 177,419 | [
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-0.01903167,
0.6007007,
0.1235535,
-0.05295429,... |
Membrane behavior of exocytic vesicles. II. Fate of the trichocyst membranes in Paramecium after induced trichocyst discharge. | A specific exocytic process, the discharge of spindle trichocyts of Paramecium caudatum, was examined by means of the electron microscope. This exocytosis is induced by an electric shock simultaneously in nearly all of the trichocysts (ca. 6,000-8,000) of a single cell. Single paramecia were subjected to the shock and ... | 177,429 | [
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0.1850396,
0.2604133,
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-0.1351348,
-0.05534747,
0.437156,
0.5631943,
0.1334185,
... |
Receptor-active growth hormone in Laron dwarfism. | The hepatic radioreceptor assay for hGH has been applied to the detection of hGH in the sera of patients with high growth hormone dwarfism (Laron dwarfism). Substantial quantities of receptor-active hGH were found in the sera of all 7 patients studied. In one patient, arginine infusion elicited a prompt increase in bot... | 177,445 | [
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0.1725182,
0.2826187,
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0.3456603,
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-0.0640287,
0.6640984,
0.2882265,
0.219895,
... |
Exposure of thyroid slices to thyroid-stimulating hormone induces refractoriness of the cyclic AMP system to subsequent hormone stimulation. | These studies evaluated the influence of an initial exposure of thyroid slices to thyroid-stimulating hormone (TSH) on the subsequent responsiveness to the hormone. Bovine thyroid slices were incubated with or without 50 mU/ml TSH for varying periods and then incubated in hormone-free medium for varying periods. Subseq... | 177,452 | [
0.09028893,
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0.3166178,
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0.07275278,
0.04993238,
0.286714,
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-0.3105209,
0.2723821,
0.494067,
-0.07065401,
-0.3397081... |
Femtomole sensitive radioimmunoassay for cyclic AMP and cyclic GMP after 2'0 acetylation by acetic anhydride in aqueous solution. | The sensitivity of radioimmunoassays for cyclic AMP and cyclic GMP has been markedly improved to readily detect femtomole (10-15) amounts in tissue extracts by acetylating the cyclic nucleotides at the 2'0 position with acetic anhydride. Acetylation of cyclic nucleotides by acetic anhydride in aqueous solution proceeds... | 177,461 | [
-0.1893642,
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0.04084293,
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0.1917816,
0.1263778,
0.2302162,
0.004881503,
0.2532035,
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0.2021904,
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0.3779313,
0.3746459,
-0.06867986,
-0.2680037,
... |
PGE1-mediated cyclic AMP refractoriness: effects of cycloheximide and indomethacin. | Human synoviocytes in culture respond to prostaglandin E1 (PGE1) by increasing their intracellular concentration of cyclic AMP. Readdition of PGE1 to cells previously treated with PGE1 elicits no change in the intracellular concentration of cyclic AMP. This refractory state is partially prevented by the inhibitors of p... | 177,463 | [
-0.156248,
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0.2921543,
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0.05981266,
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0.45874,
0.2053039,
-0.2135548,
-0.0353662... |
Modulation of platelet cyclic nucleotide content by PGE1 and the prostaglandin endoperoxide PGG2. | The effects of prostaglandin E1 and prostaglandin G2, the prostaglandin endoperoxide, on platelet cyclic nucleotide concentrations were measured in platelet rich plasma (PRP), and in washed intact platelets. PGE1 was found to be a potent stimulator of platelet cAMP levels in both PRP and washed cells, and to inhibit ag... | 177,467 | [
-0.05493137,
0.01808023,
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0.001088399,
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0.3595871,
0.04557153,
0.1314434,
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0.1566146,
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0.1340037,
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0.09988908,
-0.01192906,
-0.03899343,
-0.1701591,
0.3239566,
0.3843236,
0.2624063,
-0.068483... |
The stability of the serotypes of Bordetella pertussis with particular reference to serotype 1,2,3,4. | Strains of Bordetella pertussis in which all the organisms contain agglutinogens 1 and 3 or 1,2 and 4 are easy to identify as serotypes 1,0,3,0 and 1,2,0,4 respectively; and similarly, stable strains of serotype 1,0,3,4 are occasionally found. During repeated subcultures, passage in vivo, and lyophilization and preserv... | 177,704 | [
-0.1200513,
-0.1754434,
-0.09476917,
-0.2111755,
-0.1283968,
-0.3413948,
-0.2328989,
0.1291404,
0.129445,
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0.3184367,
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0.03137662,
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-0.05370403,
-0.2460723,
0.01513514,
0.2351005,
0.1100533,
0.1180943,
-0.2374576,
... |
Characterization of the minor polypeptides in the foot-and-mouth disease particle. | In addition to the four major polypeptides VP1 and VP4, foot-and-mouth disease virus particles contain two minor polypeptides, mol. wt. 40 X 10(3) (P40) and 52 X 10(3) (P52). Extensive purification procedures failed to remove these minor polypeptides from the virus particles. Polypeptide P40 co-electrophoresed in SDS-p... | 177,728 | [
-0.3137016,
0.0704322,
-0.008047089,
0.1248288,
0.2468134,
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-0.08088766,
0.1920626,
0.2796836,
0.01249181,
0.1207485,
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0.08738816,
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0.02086294,
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-0.269221,
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0.2824951,
0.08212499,
0.2307421,
-0.1229637,
-0.3414305,
... |
Anticonvulsant activity and selective inhibition of nicotinamide adenine dinucleotide-dependent oxidations by 10-(2-arylimino-3-acetylamino-4-thiazolidonyl) phenothiazines. | Several Several 10-(1-acetyl-4-arylthiosemicarbazido) phenothiazines and their corresponding cyclized 10-(2-arylimino-3-acetylamino-4-thiazolidonyl)phenothiazines were synthetized and characterized by their sharp melting points and elemental analyses. All compounds inhibited nicotinamide adenine dinucleotide (NAD)-depe... | 177,750 | [
-0.2079173,
0.218077,
-0.2212985,
-0.0009273607,
0.08291893,
0.03728501,
-0.05099303,
-0.1154798,
0.04839987,
-0.1617578,
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0.2015596,
0.2338865,
0.08925854,
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0.227087,
-0.5451531,
0.1578345,
-0.2906278,
0.4678494,
-0.03329262,
0.1404782,
0.04101833,
... |
The attitudes of nursing students and others about mental illness. | Student nurses tend to report somewhat moderate attitudes toward mental illness in that they appear to be less radical than psychology students, but less conservative than teacher-students in education. The student nurses' attitudes are similar to those of psychiatric residents, but more radical than psychiatric nurses... | 177,762 | [
-0.1594964,
0.1819277,
0.1454053,
-0.2740679,
0.06718487,
0.1027395,
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0.03696876,
0.205786,
0.2228461,
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0.410528,
0.03729705,
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-0.5871937,
0.2504448,
0.1313986,
-0.2117653,
0.09336757,
0.1071013,
0.1394638,
-0.16... |
The "herd approach" to bovine reproductive disorders. Part I: The diagnosis and management of infectious infertility. | The authors describe the methods employed by the Artificial Insemination Section of the Division of Veterinary Services in collaboration with the Reproduction and Bacteriology Section of the Veterinary Research Institute, Onderstepoort when herds are examined for infertility. A "herd" rather than an "individual animal"... | 177,780 | [
-0.1013823,
0.1539728,
0.1083619,
0.2064904,
-0.1141449,
-0.3232342,
-0.1127321,
0.04704911,
0.1549866,
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0.2996171,
0.08273875,
0.07886062,
0.1871017,
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-0.2834531,
-0.02910249,
-0.04494741,
-0.3983009,
-0.0936171,
0.1917657,
-0.01845255,
... |
Mouse mammary tumor virus as a model for viral carcinogenesis. | Evidence is presented suggesting that genetic control may be the limiting factor in mammary tumor virus (MTV) positive mammary oncogenesis. Studies with hybrid mice involving high and low MTV-expressing murine strains suggest that expression of MTV in milk may not be as important in tumorigenesis as previously thought.... | 177,786 | [
-0.1904071,
-0.2059608,
-0.1300166,
-0.1950966,
0.01097768,
-0.1509041,
-0.03092787,
0.03858991,
0.1289381,
0.02501217,
-0.03063809,
0.1161136,
-0.02610448,
0.04118538,
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-0.245105,
-0.04464503,
0.04505569,
0.03226449,
-0.04614441,
0.207517,
-0.04611918,
-0.0145... |
Mammary gland as a morphological end point in carcinogenesis studies. | The murine mammary tumor system is characterized by the presence of intermediate preneoplastic mammary cell populations. The intermediate mammary cell populations are characterized as either alveolar hyperplasias or ductal hyperplasias. The most frequently encountered preneoplastic cell population is the hyperplastic a... | 177,787 | [
-0.1505715,
-0.07082865,
-0.1760014,
-0.3621618,
-0.1411131,
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0.08892675,
-0.007719477,
0.1858634,
0.1927595,
-0.1234275,
-0.2052791,
0.03606173,
-0.1490278,
-0.4437673,
-0.2635494,
-0.1535092,
0.23828,
0.5758461,
-0.01039761,
0.3151405,
0.2332153,
-0.1461731,... |
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