title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Relationship between elongation factor I- and elongation factor II- dependent guanosine triphosphatase activities of ribosomes. Inhibition of both activities by ricin. | The elongation factor 1- and elongation factor 2-dependent GTPase (guanosine triphosphatase) activities of ribosomes are inhibited by ricin, a toxic protein known to inactivate the 60S ribosomal subunit. It is suggested that also in eukaryotic ribosomes a "GTPase site', located on the larger subunit, is common to the t... | 173,282 | [
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Utilization of gluconate by Escherichia coli. A role of adenosine 3':5'-cyclic monophosphate in the induction of gluconate catabolism. | 1. Cultures of Escherichia coli growing on gluconate use both gluconate and glucose when glucose is added. 2. Glycerol-grown cells adapt to gluconate utilization even in media containing glucose as well as gluconate. 3. The rates of gluconate utilization by cells growing on a mixture of glucose and gluconate, and the s... | 173,298 | [
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Subcellular localization of superoxide dismutase in rat liver. | The subcellular localization of superoxide dismutase was investigated in rat liver homogenates. Most of the superoxide dismutase activity is present in the soluble fraction (84%), the rest being associated with mitochondria. No indications for the occurrence of superoxide dismutase in other subcellular structures, part... | 173,300 | [
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Influence of anti-oestrogens on the specific binding in vitro of (3H)oestradiol by cytosol of rat mammary tumours and human breast carcinomata. | The anti-oestrogenic potential of two nitrogen-mustard-containing compounds, I.C.I. 79792 and I.C.I. 85966, was studied. I.C.I. 85966 usually did not decrease specific binding of [3H]oestradiol by breast-tumour cytoplasmic proteins. I.C.I. 79792 decreased specific [3H]oestradiol binding, but not to the same extent as s... | 173,302 | [
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Stimulation of phosphoenolpyruvate carboxykinase (guanosine triphosphate) activity by low concentrations of circulating glucose in perfused rat liver. | 1. After nicotinic acid treatment, rat liver glycogen is depleted and phosphoenolpyruvate carboxykinase activity increased, to about twice the initial value. 2. The increase in phosphoenolpyruvate carboxykinase activity promoted by nicotinic acid is prevented by cycloheximide or actinomycin D, suggesting that this effe... | 173,301 | [
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[Experimental results with systematically synthetized substances for antiviral chemotherapy / 4th communication: The role of physical binding in the synthesis of antiviral chemotherapeutics and its influence on potential mutagenic effects (author's transl)]. | 13 antiviral substances containing specific hydrogen bridge linkage systems out of the classes of 2-substituted 4-phenylthiazoles, 4-phenylimidazoles and indandiones-(1,3) were tested for their mutagenic potency in the host-mediated assay, in bone marrow of rats, in spermatogonia of mice and in the micronucleus test of... | 173,351 | [
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[Determination of anti-cytomegalovirus antibodies by the immunoperoxidase method: comparison with the methods of complement fixation and immunofluorescence]. | Indirect immunoperoxidase technique (IIP) has been employed for determination of IgG antibody titer to cytomegalovirus (CMV) in sera from 110 blood donors. Titers have been compared with complement fixation (CF) and indirect fluorescent antibody (IFA) technique titers, the latter being applied to determination of all s... | 173,374 | [
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Characterization of the T antigen induced by SV40. | 3 or 4 antigenic SV40 specific components were established in hamster tumors induced by SV40-transformed cells, using linear sucrose gradient centrifugation and Sephadex G-200 column chromatography. The lightest component, approximate molecular weight 21,000, did not inhibit the nuclear staining of SV40-transformed cel... | 173,379 | [
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Tubuloreticular structures in human lymphoid cell lines. A cell biological study. | Human lymphoid cell lines were studied as an experimental model for the spontaneous or induced occurrence of tuburloreticular structures (TRS). It was possible to induce TRS after culturing the EB-3 cell line with 20 mug/ml bromodeoxyuridine (BrUdR) during 96 h. Starvation, culturing at lower temperature (32 degrees) o... | 173,383 | [
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Influence of carbon tetrachloride or riboflavin on liver carcinogenesis with a single dose of aflatoxin b1. | Liver carcinogenesis with a single dose of aflatoxin B1 (7 mg/kg body weight) has been investigated in a group of female Wistar strain rats by repeated biopsies and necropsies. Another group received a subsequent intoxication with carbon tetrachloride by inhalation (approximately 200 doses) and another one was overload... | 173,384 | [
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Stimulation of cholesterol ester exchange by lipoprotein-free rabbit plasma. | A fraction in normal and hypercholesterolemic rabbit plasma of density greater than 1.25 stimulates the exchange of cholesterol esters between very low density and low density lipoproteins from hypercholesterolemic rabbit plasma. The exchange does not result from lecithin:cholesterol acyltransferase activity. The activ... | 173,390 | [
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Protein synthesis in homologous and heterologous cell-free systems from chick embryo connective tissues. | Two homologous systems for cell-free protein synthesis from chick embryo connective tissues are described. Both the skin polysomes and the wing-leg polysomes are active in collagen synthesis, but they have different requirements for optimum protein synthesis. Protein synthesis was not dependent on tissue-specific facto... | 173,396 | [
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[Structural transitions in DNA, isolated from normal and neoplastic cells]. | A decrease of temperature transition in spin-labeled DNA isolated from leucose cells compared with normal cells is found. It is shown by kinetic formaldehyde method that it may be the result of many defects in the secondary structure of macromolecule in DNA1. The spin label method is shown to be used for the analysis o... | 173,399 | [
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[EPR- and IR-spectroscopic study of the processes of carbonization of amino acid crystals]. | Initial stages of "low temperature" carbonization in crystal amino acids have been studied by ESR- and IR-spectroscopy. It was revealed that block polycondensation of amino acids with the formation of polypeptide chains took place. In the air oxygen also surface carbonization of crystals took place; it became stronger ... | 173,400 | [
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[Rate of interaction of ferricytochrome c with negatively charged liposomes from natural lecithin: effect of the physicochemical state of the membrane hydrophobic layer]. | The absorption velocity of ferricytochrome c on the surface of liposomes from egg lecithin containing 10% of lauric acid was studied. Liposomes were prepared from lecithin of three fractions which differed by the composition of fatty acids, unsaturation and the lipid interaction decreased at the temperature below T phi... | 173,407 | [
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Effects of catecholamines on rat myocardial metabolism. I. Influence of catecholamines on energy-rich nucleotides and phosphorylated fraction contents. | 1. The influence of catecholamines (adrenaline and noradrenaline) on energy metabolism of the rat myocardium has been studied by incubating slices of this tissue with these hormones and by following the levels of the different phosphorylated fractions and adenylic nucleotides. 2. Similar effects are obtained with both ... | 173,416 | [
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Primary oat cell carcinoma of the larynx: an ultrastructural study. | An extrapulmonary oat cell carcinoma arising in the larynx is described. Ultrastructurally the tumor is identical to the oat cell carcinoma of pulmonary origin. The pressure of neurosecretory granules in our case strongly suggests that the tumor is derived from Kulchitsky-like cells, a histogenesis previously proposed ... | 173,456 | [
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Ultrastructural study of a postinflammatory "tumor" of the lung. | A typical postinflammatory "tumor" of the lung was resected from an asymptomatic 22-year-old white woman. Light and electron microscopic studies showed the lesion to be composed of metaplastic pneumonocytes, proliferated stroma, and chronic inflammatory cells. These findings confirm the inflammatory nature of the lesio... | 173,457 | [
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Primary malignant fibrous histiocytoma of bone. | A review of over 400 primary bone tumors yielded 11 lesions with features allowing classification as malignant fibrous histiocytoma on a purely histological basis. Correlation with roentgenograms and clinical data indicated that these tumors occurred as osteolytic lesions associated with a high incidence of pathologic ... | 173,460 | [
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Contrasting effects of hypoglycemia on plasma renin activity and cyclic adenosine 3',5'-monophosphate (cyclic AMP) in low renin and normal renin essential hypertension. | Insulin-induced hypoglycemia previously has been shown to provoke a beta-adrenergic response that normally results in an increase in plasma renin activity (PRA). In our study, hypoglycemia induced definite increases in PRA in a group of five patients with normal renin essential hypertension but failed to do so in a gro... | 173,476 | [
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On the metabolism of lipoprotein-X (LP-X). | The characteristic low-density lipoprotein of cholestasis (LP-X) earlier described for humans is found with identical properties in dogs and rats after experimental cholestasis. After ligation of the common bile duct, LP-X may be detected in the plasma within the first 20 hours. A period of marked increase in concentra... | 173,481 | [
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E and EAC rosetting lymphocytes in patients with carcinoma of bronchus I. Some parameters of the test and of its prognostic significance. | Using peripheral blood lymphocytes separated by a Ficoll method and suspended in saline, means of 77-1% (s.d. 5-2) E rosettes (T lymphocytes) and 20-1% (s.d. 6-7) EAC rosettes (B lymphocytes) have been obtained with normal healthy donors. Poorer E-rosette formation resulted from higher centrifugation speeds during the ... | 173,486 | [
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Effects of repeated doses of scopolamine on the electroencephalographic stages of sleep in normal volunteers. | Single doses of scopolamine markedly alter sleep patterns in man. This study intended to evaluate the persistence of these changes during continued administration. The design consisted of a sequence of habituation, no-medication, saline (control), scopolamine (0.006 mg/kg intramuscularly 3 consecutive nights), and sali... | 173,490 | [
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Variations in thyroid function and sleep in healthy young men. | 1. The total serum thyroxine, tri-iodothyronine resin uptake, total plasma protein concentration and the free thyroxine index (FTI) were determined repeatedly, at 07.15, 13.00 and 22.30 hours over 4 days, in six healthy young men. 2. There was a significant diurnal variation in the total serum thyroxine concentration b... | 173,492 | [
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ADP-ribosylation of DNA-dependent RNA polymerase of Escherichia coli by an NAD+: protein ADP-ribosyltransferase from bacteriophage T4. | A protein from bacteriophage T4 responsible for the alteration of host DNA-dependent RNA polymerase and absent in T4 alt- phage was purified from T4 phage and enriched from T4-infected cells. It is injected during infection together with the known internal proteins. It has a molecular weight of about 70000 and catalyse... | 173,540 | [
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Procollagen biosynthesis by embryonic-chick-bone polysomes. Estimation of the relative numbers of active proalpha1 and proalpha2 messenger ribonucleic acids. | Both total polysomes and polysomes of different size classes isolated from embryonic chick cranial bones were allowed to complete their nascent polypeptide chains in a cell-free system containing rabbit reticulocyte post-ribosomal supernatant fraction. In this system, no de novo initiation of polypeptide synthesis occu... | 173,541 | [
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Nitrogenase from Azotobacter chroococcum. Purification and properties of the component proteins. | 1. A large-scale purification of the nitrogenase components from Azotobacter chroococcum yielded two non-haem iron proteins, both of which were necessary for nitrogenase activity and each had a specific activity of approximately 2000 +/- 300 nmol of acetylene reduced/mg protein per min in the presence of sautrating amo... | 173,545 | [
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0.2179648,
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Characterization of calf-ovary adenosine;3':5'-monophosphate-dependent protein kinases and adenosine-3':5'-monophosphate-binding proteins. | Protein phosphokinase activity from the calf ovary cytosol (105000 X g supernatant fraction) has been resolved by chromatography and polyacrylamide gel electrophoresis into two major protein kinases, PK-H1 and PK-H2, both dependent on adenosine 3':5'-monophosphate (cyclic AMP). The enzymes have similar molecular weight... | 173,547 | [
-0.1192137,
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-0.3070433,
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0.06303792,
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0.2172,
0.1227416,
0.2884585,
0.2145053,
-0.4143136,
... |
Depression of humoral and cell-mediated immune responses by coxsackieviruses in mice. | Adult mice infected with coxsackieviruses A-15, B-1, B-2, B-4 and B-6 showed depressed antibody responses to unrelated antigens; mice infected with coxsackievirus B-3 developed reduced humoral and cell-mediated immune responses. These findings might have clinical and epidemiological implications. | 173,571 | [
-0.27794,
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0.01354135,
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0.2025212,
0.06941011,
0.4001901,
0.1352854,
0.2369616,
-0.2036257,
-... |
Specific and non-specific phosphatases in the miracidium of Fasciola hepatica L. | Localization and activities of alkaline phosphatase, ATPase, 5-nucleotidase, glucose-6-phosphatase, thiamine pyrophosphatase and nucleoside diphosphatase were studied in the miracidium of Fasciola hepatica L. Except for nucleoside diphosphatase whose activity in the miracidium was not observed, all the enzymes were mos... | 173,637 | [
-0.2033718,
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0.2660928,
0.009477492,
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0.3365706,
0.09669199,
-0.018... |
Epithelial basement membrane of bovine renal tubuli. Isolation and analysis of the carbohydrate chains. | The carbohydrate chains present in the tubular basement membrane of bovine kidney were studied. Digestion with collagenase followed with pronase resulted in a complete solubilization of the basement membrane. The different glycopeptides were purified by gel filtration and ion-exchange chromatography. Two kinds of carbo... | 173,641 | [
-0.03922139,
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0.0217404,
-0.1621814,
0.346705,
0.03189185,
-0.2427254,
... |
Effect of desdanine on nucleoside diphosphate kinase and pyruvate kinase of Escherichia coli. | Kinetic analysis demonstrated that the irreversible inhibition of nucleoside diphosphate kinase of Escherichia coli by desdanine proceeds via a reversible Enzyme-Inhibitor complex. It is known that pyruvate kinase of E. coli becomes inactive upon prolonged dialysis in the absence of a reducing reagent, such as dithioth... | 173,700 | [
-0.1036413,
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0.3214986,
0.3179567,
0.003231857,
-0.2801152,
... |
An application of neuroendocrinological studies in autistic children and Heller's syndrome. | The response of plasma 11-hydroxycorticosteroids (11-OHCS) to intravenous pyrogen as well as the circadian rhythm of plasma 11-OHCS levels were investigated in seven autistic children and in two children with Heller's syndrome. In autistic children, the stress response, which is acquired in an earlier stage of developm... | 173,703 | [
-0.1462061,
0.1276774,
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0.06576305,
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0.09579313,
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0.01590928,
0.3784765,
0.02864293,
0.0161048... |
Mutants of Aspergillus nidulans lacking nicotinamide adenine dinucleotide-specific glutamate dehydrogenase. | Ten mutants of Aspergillus nidulans lacking nicotinamide adenine dinucleotide-specific glutamate dehydrogenase (NAD-GDH) have been isolated, and their mutations (gdhB1 through gdhB10) have been shown to lie in the gdhB gene. In addition, a temperature-sensitive gdhB mutant (gdhB11) has been isolated. A revertant (desig... | 173,707 | [
-0.2303856,
-0.2510001,
-0.3202033,
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0.03047013,
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0.356866,
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0.09398283,
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-0.152239,
0.2621465,
0.678518,
0.125583,
... |
Suppressor-induced structural changes in a missense L-ribulokinase of Escherichia coli. | A suppressor mutation specific for a missense codon in the L-ribulokinase structural gene of the L-arabinose operon of Escherichia coli B/r enhanced L-arabinose utilization by the strain containing the missense codon. Electrophoretic comparisons of the wild-type, missense, and suppressed missense L-ribulokinases indica... | 173,711 | [
0.2866809,
0.1332003,
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0.1358286,
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0.008771696,
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0.2685602,
-0.1422083,
0.3182766,
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0.3241284,
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0.3413009,
-0.0563173,
0.5158197,
0.3434332,
-0.09686871,
-0... |
High-speed liquid chromatography of polychlorinated biphenyls and related compounds. | High-speed liquid chromatography in the system silica gel-dry n-hexane has been used to characterize the behaviour of a series of commercially available mixtures of chlorinated biphenyls, viz., Aroclor 1221-1268. An attempt has been made to assign a large number of peaks in the chromatograms of the Aroclors to the indi... | 173,733 | [
0.02076543,
0.2141458,
0.153645,
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0.1501863,
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0.3042528,
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0.3660495,
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0.3314862,
0.2998334,
-0.03509023,
0.2873847,
0.1070785,
-0.3231068,
0... |
Mechanism of immunologic resistance to herpes simplex virus 1 (HSV-1) infection. | Susceptibility of adult mice to i.p. infection with HSV-1 was greatly increased by administration of a single dose of cyclophosphamide. Mortality of cyclophosphamide-treated virus-infected mice was associated with increased virus replication and pathologic changes in brain and liver. The development of a fatal infectio... | 173,758 | [
0.009403441,
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0.1491803,
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0.1677217,
0.03987931,
-0.005697352,
0.08601541,
0.6176867,
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-0.11027,
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0.6262059,
-0.2224859,
-0.1213143,
-0.0176446... |
Cytoplasmic oestrogen receptor complex of female ovine pituitary: changes associated with the reproductive state and oestradiol treatment. | Binding of oestrone and oestradiol to a pituitary cytosol receptor was studied in ovariectomized sheep during the breeding season, during anoestrus and after oestradiol treatment during anoestrus. All sheep were ovariectomized 2 weeks before removal of the anterior pituitary. Oestrogen treatment consisted of the subcut... | 173,786 | [
0.02711285,
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0.05359847,
0.1024495,
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0.1998791,
0.5267587,
0.02880788,
-0.... |
Poliovirus proteins associated with the replication complex in infected cells. | Viral polypeptides associated with the membrane-free replication complex of poliovirus RNA were multiple in nature. The structural protein precursors [VP0, VP1, VP3] predominated, and because they were found in a cytoplasmic component with the same S value and density as the replication complex are likely to be attache... | 173,800 | [
-0.3027652,
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0.1181154,
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0.06735749,
0.1986467,
-0.0408852,
-0.2503645,
0.... |
Comparison of the intermediary metabolism of fatty acids in denervated and dystrophic murine skeletal muscle. | Certain aspects of lipid metabolism have been examined in denervated muscle from normal mice and in dystrophic muscle from mice of the Bar Harbor strain 129. A number of parameters show no change or similar changes. For example, the utilization of palmitate-[1-14C] and palmitylcarnitine by mitochondria from denervated ... | 173,805 | [
-0.3798755,
-0.05462435,
0.05372383,
-0.2212472,
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0.06105605,
0.2362609,
0.1091986,
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0.4465964,
0.07693481,
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0.03563794,
0.09446476,
0.382716,
0.03275154,
0.3170454,
0.02556616,
... |
Retroperitoneal ganglioneuroblastoma: a kaleidoscope of neuronal degeneration. A light and electron microscopic study. | The light and electron microscopic features of an unique retroperitoneal ganglioneuroblastoma in a four-year-old female are described. The unprecedented concurrence of Hirano, zebra, membranous cytoplasmic (MCB), and Pick bodies in the same population of neoplastic, sympathetic ganglion cells provides further evidence ... | 173,810 | [
-0.2424808,
-0.2859112,
-0.1034456,
-0.1799779,
-0.1057312,
-0.3884432,
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0.01387396,
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0.1927358,
0.1076855,
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0.2942727,
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-0.3744969,
0.4286359,
0.1015671,
-0.1161255,
0.... |
Light-cored dense particles in mitochondria of a patient with skeletal muscle and myocardial disease. | A 15-year-old boy with skeletal muscle and myocardial disease was found to have large numbers of abnormal muscle mitochondria, the distinguishing feature of which was the presence of many light-cored dense particles. These particles bore a marked resemblance to those seen in situations where mitochondria accumulate cal... | 173,811 | [
-0.3594249,
0.3271957,
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0.0944948,
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0.1805887,
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0.09107899,
0.09210765,
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0.135065,
0.1252997,
0.419953,
0.1538772,
0.008030443,
0.144... |
Gluconeogenic response to mannoheptulose in the rat. | Since administration of mannoheptulose induces temporary hyperglycemia, the present study was conducted to elucidate this phenomenon. The results indicate that mannoheptulose stimulates the activity of hepatic fructose-1,6-diphosphatase and phosphoenolpyruvate carboxykinase, and enhances incorporation of alanine into b... | 173,818 | [
-0.1422063,
-0.3045284,
-0.3130192,
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0.2071964,
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0.2180587,
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0.2026841,
0.1965139,
-0.04413272,... |
Morphology and histochemistry of the endometrial cup. | The luminal and cut surface of endometrial cups were examined by scanning electron microscopy. The distribution of PAS-positive and lipid materials in cup tissue was studied and most of the lipid material was localized in the large polyhedral cup cells. The lipid droplets gave positive reactions for DNPH in the cholest... | 173,848 | [
0.04936691,
0.1851241,
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0.4123809,
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0.06889167,
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0.07851153,
0.2756117,
0.4330005,
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-0.... |
5' nucleotide sequence of sindbis viral RNA. | The 5' sequence of Sindbis viral RNA is m (7)G(5') pppApUpGp... | 173,879 | [
-0.3318202,
-0.08476778,
-0.4042084,
-0.0391991,
0.3077053,
0.207597,
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0.1763218,
0.1989684,
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0.3561158,
0.006747957,
0.1509983,
-0... |
Comparison of an avian osteopetrosis virus with an avian lymphomatosis virus by RNA-DNA hybridization. | Myeloblastosis-associated virus (MAV)-2(0), a virus which was derived from avian myeloblastosis virus and induced a high incidence of osteopetrosis, was compared with avian lymphomatosis virus 5938, a recent field isolate which induced a high incidence of lymphomatosis. The following information was obtained. (i) MAV-2... | 173,880 | [
-0.2713587,
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0.1063153,
-0.4289257,
0.3134607,
-0.4299625,
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0.07862017,
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0.1340338,
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0.3294901,
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0.2474169,
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0.1694577,
0.4273767,
0.01888985,
-0.3658265,
... |
Tick-borne viruses in Finland. | Ixodes ricinus is the only one of six tick species reported from Finland found to carry viruses. It transmits tick-borne encephalitis and Uukuniemi viruses, and transmission of a Kemerovo group virus is suggested by antibody findings. Tick-borne encephalitis is common only in the SW-archipelago; it is also found near t... | 173,939 | [
-0.2946443,
0.1290673,
0.1192228,
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0.6093652,
0.0522199,
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0.237905,
-0.1876858,
-0.04870495,
0.17... |
Effect of diet on fatty acids in the lipoprotein cholesteryl esters of type IIa and normal individuals. | Four normal and two individuals with type IIa hyperlipoproteinemia were placed on the National Heart and Lung Institute Type IIa Diet (less than 300 mg of cholesterol per day, high polyunsaturated, low saturated fat diet) for 1 week and on a normal diet the following week. Plasma samples were obtained and the cholester... | 173,967 | [
-0.1675246,
0.2499788,
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0.3571271,
0.06358176,
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0.4022573,
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0.5593868,
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0.001241746,
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0.03520965,
0.1657008,
0.6358421,
-0.05547691,
... |
Effect of breast-feeding on seroresponse of infants to oral poliovirus vaccination. | Three hundred Indian infants between 6 and 51 weeks of age were divided into six groups and given three doses of trivalent oral polio vaccine (OPV) of known adequate potency. One group was on unrestricted breast-feeding with mandatory breast-feed during the interval between 30 minutes before and 15 minutes after each d... | 174,056 | [
0.04534567,
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0.182902,
0.4188743,
0.270122,
0.0912708,
0.1... |
Pediatric familial type II hyperlipoproteinemia: therapy with diet and colestipol resin. | Effects of a low-cholesterol, polyunsaturate-rich diet and a synthetic organic bile sequestrant polymer (U26,597A, colestipol) were studied in 21 children, heterozygous for familial hypercholesterolemia. Total cholesterol, beta-lipoprotein cholesterol, and triglyceride were measured twice on habitual diet, monthly for ... | 174,057 | [
0.08255361,
0.6675103,
0.1429875,
0.08411375,
0.2502082,
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0.1106616,
0.01581552,
0.1135093,
0.07450454,
0.20... |
Mapping of biological functions on RNA of avian tumor viruses: location of regions required for transformation and determination of host range. | A map of the large T1 oligonucleotides of the RNA of Prague Rous sarcoma virus, strain B (Pr RSVb) has recently been established (Coffin and Billeter, submitted for publication). Since the RNA of Rous associated virus, type 1 (RAV-1) lacks many of the large 1 oligonucleotides of Pr RSV-B and contains others not present... | 174,075 | [
0.05693369,
0.02667279,
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0.03439593,
0.07367551,
0.3752423,
0.1031998,
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0.05788752,
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0.4888446,
0.3614517,
0.4363912,
0.1785493,
-0.4216281,... |
Human papillomavirus DNA: physical map. | Human papillomavirus (HPV) DNA form I (supercoiled) was prepared from plantar warts. HPV DNA was cleaved with restriction enzymes obtained from the following sources: escherichia coli (EcoRI), Hemophilus influenzae strain Rd (both unfractionated Hind and aeparated HindII and HindIII enzymes) and Hemophilus parainfluenz... | 174,077 | [
-0.3155734,
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0.2929616,
0.07678332,
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0.01350664,
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0.04031786,
0.02486968,
-0.3383586,
-0.09162761,
0.176973,
0.2183622,
-0.252113... |
Signal input for a chemotactic response in the cellular slime mold Dictyostelium discoideum. | Drops with different concentrations of 3':5'-cyclic AMP were deposited at various distances from small populations of Dictyostelium discoideum amoebae, and the distances over which 50% of the amoebae drops reacted positively were determined. The linear regression analysis of a bouble logarithmic plot of distance agains... | 174,088 | [
-0.2169082,
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0.04061961,
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0.1212331,
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0.2641688,
0.7370503,
0.3890951,
0.1338351,
... |
Binding, internalization, and degradation of low density lipoprotein by normal human fibroblasts and by fibroblasts from a case of homozygous familial hypercholesterolemia. | Skin fibroblasts from a patient with homozygous familial hypercholesterolemia (HFH) were compared with normal skin fibroblasts with regard to binding, internalization, and degradation of iodinated human low density lipoprotein (LDL). Like other cell lines from HFH patients, the mutant cells showed no suppression of ste... | 174,096 | [
-0.1357331,
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0.05155064,
0.2870818,
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0.07189748,
0.07932975,
0.2549727,
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0.3135168,
0.08443965,
0.6717464,
-0.268699,... |
Characteristics common to choleretic increments of bile induced by theophylline, glucagon and SQ-20009 in the dog. | Theophylline, glucagon, and SQ-20009 induce a choleresis in the dog characterized by a proportionate increase in erythritol clearance and bile flow, no increase in bile salt excretion, and by an isosmotic solution of similar electrolyte composition. The increment in bile appears to originate at the canaliculus in respo... | 174,139 | [
0.003038903,
0.07420254,
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0.2589738,
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0.1789603,
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0.02443884,
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0.240392,
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0.1359066,... |
Nicotinamide adenine dinucleotide degradation in infarcted cardiac muscle. | Nicotinamide adenine dinucleotides (NAD, NADH2, NADP, and NADPH2) levels decrease in myocardial dog tissue after the ligature of the coronary artery branch. The activity of a glycohydrolytic enzyme acting on NAD and releasing nicotinamide in an equivalent amount was of the same order of magnitude in infarcted tissue, i... | 174,168 | [
-0.2790954,
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0... |
[Effects of ACTH on plasma insulin and glucose]. | The authors studied the effects of intramuscular and intravenous administration of ACTH on plasma glucose and insulin in rabbits. They found well marked differences --specially in insulin behavior-- between the effects of ACTH in rabbits and in humans. In rabbits, the investigators observed hyperinsulinism unable to de... | 174,173 | [
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0.2174035,
... |
[Supravalvular ring type aortic stenosis with hypoplasia of the ascending aorta and stenosis of the origin of the innominate artery. Surgical correction]. | The authors report the case of a 19 year old woman with supravalvar aortic stenosis and hypoplasia of the ascending aorta with stenosis at the origin of the innominate artery. This was a sporadic form, without mental deficiency nor facial dysmorphia. No similar case was found in the family. The patient had three attack... | 174,197 | [
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0.03854493,
0.4255954,
0.6905313,
0.4214777,
-0.0357022... |
[Istope examinations in coronary intensive care units]. | Radio-isotopes may be of use in investigation of patients with heart disease on an intensive care unit. These investigations are not traumatic. The radio-isotopes are innocuous and reliable, the examinations may be easily repeated and are therefore of great interest in diagnosis and prognosis of cardiovascular disease. | 174,198 | [
-0.1735885,
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... |
[4 cases of osteomalacia during anticonvulsant or sedative treatment]. | The authors report osteomalacia in 3 cases of epilepsy and one case of coronary heart disease treated with phenobarbitone, either alone or associated with other anticonvulsants. There were clinical signs in all cases and typical radiological signs in 3 cases, a characteristic laboratory syndrome in 4 cases. In the 3 ca... | 174,222 | [
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0.3280274,
0.3398585,
0.3125351,
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0.34... |
The compound eye in the opaque-eye phenotype of Drosophilia melanogaster. | The compound eye of the opaque-eye mutant of Drosophila melanogaster was investigated by means of electron microscopy to determine the morphological and physical properties of ommatidial elements. These elements in the mutant were found to differ from those of the wild-type flies in the following ways: (1) The cuticula... | 174,240 | [
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[Xeroradiographic field control in telecobalt therapy of the cranial and ear-nose-throat regions]. | The possibility of direct field verification by xeroradiography in Co-60-teletherapy of the head- and ENT-regions is described. By the effect of intensified contours, anatomical details may present themselves sufficiently as to make possible an objective verification of the irradiation. The particular advantages of thi... | 174,255 | [
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... |
[Effect of ACTH on glucose-6-phosphate dehydrogenase and transketolase activity in mitochondria and hyaloplasm of rabbit liver]. | The glucose-6-phosphate dehydrogenase and transketolase activities in mitochondria and hyaloplasm of the rabbit liver were studied as affected by ACTH injected daily in a dose of 10 u/kg of weight for two weeks. It was shown that the activity of glucose-6-phosphate dehydrogenase was unchanged neither in mitochondria no... | 174,259 | [
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[Determination of the subtype membership of the epizootic foot-and-mouth disease virus by means of the agar gel diffusion test]. | Comparative studies were carried out by means of the agar gel-diffusion technique (AGDT) to establish the antigenic identity between the epizootic foot-and-mouth disease strain (the Nch/73 representative strain) and the standard viruses of type A. The epizootic strain was found to belong to the subtype group A5. Discus... | 174,281 | [
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... |
[Ultrastructure and morphogenesis of ceroid pigment. II. Late changes of lysosomes in Kupffer cells of rat liver after phagocytosis of unsaturated lipids (author's transl)]. | Wistar rats were injected intravenously with cod liver oil emulsion. The lipid droplets ere phagocytized by Kupffer cells and stored in lysosomes. The transformation of these lipid-containing lysosomes into ceroid pigment granules was studied electron-microscopically and cytochemically for a period of 12 weeks after th... | 174,283 | [
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Intraalveolar foam cells associated with lipidosis-like alterations in lung and liver of rats treated with tricyclic psychotropic drugs. | Histological, histochemical, and ultrastructural examinations were performed on pulmonary and hepatic tissues of rats after prolonged oral treatment with several tricyclic antidepressants and two neuroleptics, which are all of amphiphilic character. The antidepressants ipindole, imipramine, clomipramine, 1-chloro-amitr... | 174,284 | [
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... |
[Comparative light and electron microscopic study on liver cell inclusions in chronic alcoholic liver damage (author's transl)]. | Liver cell inclusions in chronic alcoholic liver damage observed by means of the ligth microscope proved by correlated electron microscopy to be bile depositions, autophagic vacuoles, megamitochondria, alcoholic hyalin or accumulation of ribosomes. These liver cell inclusions are usually identifiable at the light micro... | 174,340 | [
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[Nervous system lesions in juvenile angiofibromas of the base of the skull with intracranial spread]. | The authors examined the nervous system in 12 patients with intracranial dissemination of an adolescent angiofibroma of the brain basis. It was possible to depict signs of a lesion of some cranial nerves and the brain stem as well as x-ray confirmation of a bone destruction in the brain basis. The found changes were co... | 174,348 | [
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[Antimycin A-resistant oxygen consumption in rabbit reticulocytes]. | In rabbit reticulocytes there exists an Antimycin A-resistent oxygen consumption. It amounts to about 20% of the total oxygen consumption, independently of the degree of maturation of the cells and of the presence of external substrates. The main substrate of the Antimycin A-resistent oxygen consumption is glucose, whi... | 174,350 | [
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... |
Determination of plasma aldosterone in children by thin layer chromatography and radioimmunoassay. | An accurate and relatively simple radioimmunoassay for the determination of aldosterone concentration in peripheral plasma has been developed, 0.5-2.0 ml plasma with added [1,2-3H]aldosterone is extracted with dichloromethane. Purification of the extract is achieved by thin later chromatography in the system benzene-ac... | 174,368 | [
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Hepatic prolyl hydroxylase activity in experimental cirrhosis. | Hepatic collagen synthesis was studied during progressive fibrosis induced by carbon tetrachloride in male Sprague-Dawley rats by determination of prolyl hydroxylase activity and hydrocyproline levels along with morphological assessment of fibrosis. Cirrhosis was present after approximately 4 weeks treatment. Prolyl hy... | 174,370 | [
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Diagnostic applications of the fluorescent antibody method. | Reagents and equipment are now readily available to make fluorescent antibody techniques routine diagnostic procedures. Antinuclear antibodies are detectable by such methods and are useful in the diagnosis of autoimmune disease. By defining not only the site of tissue damage but also the specific components deposted at... | 174,415 | [
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Multilocular cyst of the kidney. Report of three cases with review of the literature. | Multilocular cyst of the kidney is an uncommon lesion. Approximately 70 cases are reported in the literature, with more than half occurring in children. The etiology and pathogenesis are not known, although the microscopic appearance in certain cases resembles that of Wilms' tumor. Three additional cases are presented ... | 174,421 | [
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A case of watery diarrhea, hypokalemia and hypercalcemia associated with nonulcerogenic islet cell tumor of the pancreas. | A case of watery diarrhea, hypokalemia and hypercalcemia associated with an islet cell tumor was described. A 62-year old man exhibited frequent watery diarrhea and hypokalemia for two years. He had no peptic ulcer and serum gastrin level was normal. His serum calcium was abnormally high and serum phosphate was lowered... | 174,423 | [
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0.1122806,
0.3345799,
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0.03766831,
... |
On the skeletal maturation of Japanese-American White hybrids. | The skeletal maturation of Japanese-American White hybrids is discussed in relation to that of Japanese and Whites. Assessment of skeletal maturation was made on 323 radiographs of 57 boys and 151 of 33 girls studied semi-longitudinally from 3 to 18 years on the basis of the Tanner-Whitehouse method (62). The skeletal ... | 174,438 | [
-0.07827323,
0.2781612,
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... |
Effect of glucagon on secretin-stimulated bile flow. | The effect of glucagon on secretin-stimulated bile flow was evaluated in dogs with chronic biliary and gastric fistulas. Evaluation of the effects of secretin and glucagon alone on hepatic bile flow indicated that the calculated maximal response (CMR) values of the two agents were similar. Secretin increased the bicarb... | 174,445 | [
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0.08607687,
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0.1844395... |
Hepatic metabolism of genetically diabetic (db/db) mice. I. Carbohydrate metabolism. | Hepatic carbohydrate metabolism in genetically diabetic mice (db/db) and their normal littermates has been studied. In db/db mice, body water was below normal and declined with age. The liver of db/db mice was abnormally large in relation to the metabolic mass of the body at all ages studied. In db/db mice, hepatic gly... | 174,448 | [
-0.2121958,
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0.1476049,
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0.03231687,
0.243931,
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A comparative appraisal of emphysematous cholecystitis. | There is ample evidence from this retrospective comparison to indicate that emphysematous cholecystitis does merit clinical distinction apart from acute cholecystitis. It is an acute infection of the gallbladder caused by a specific group of bacteria that may be aided by some aspect of local ischemia. Cholelithiasis do... | 174,453 | [
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0.06231245,
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0.2740485,
0.2244165,
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Malignant hepatoma associated with acquired hepatic cutaneous porphyria. | A 60-year-old woman with a three-year history of an acquired hepatic cutaneous porphyria was discovered to have a porphyrin-producing malignant hepatoma. An attempt was made to treat her with fluorouracil perfused through a hepatic artery catheter. It did not produce shrinkage of the tumor, but the patient remains aliv... | 174,497 | [
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0.2145419,
0.1162428,
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... |
Histophysiology of the vegetative peripheral nervous system of skin. | Preterminal nerve fibers of the peripheral vegetative nervous system make inmediate contact (neuro-effector-areas) to interstitial cells (I.C.). This connection is characterized through a common glycocalyx with the nerve fiber. The I.C. are specific innervated cells and differ morphologically from Schwann-cells, fibroc... | 174,499 | [
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0.0023567,
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0.1487511,
0.425347,
-0.06532186,... |
Acute idiopathic polyneuritis caused by cytomegalovirus. | Cytomegalovirus was isolated from the PBBC from a patient with acute idiopathic polyneuritis. Viremia occurred during the early phase of the neurologic disease, preceding viruria, and was accompanied by specific CMV-IgM antibodies, which indicates a recently acquired infection. Complement fixing antibodies to CMV remai... | 174,502 | [
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0.2717514,
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0.1132991,
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0.02925526,
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Swinepox. Virus isolation, experimental infections and the differentiation from vaccinia virus infections. | The isolation of swinepox virus in primary pig kidney cell cultures is reported. The differentiation from vaccinia virus was possible with challenge infections of convalescent pigs and the use of the agar gel diffusion precipitation (AGDP) test and immuno-electroosmophoresis (IEOP). Using both immune precipitation test... | 174,522 | [
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-0.09681722,
... |
Ultrastructural aspects of experimental swinepox with special reference to inclusion bodies. | A light and electron microscopic study was performed on pox-like epidermal lesions in an experimentally infected pig. Light microscopical investigation of semithin sections revealed the presence of nuclear vacuoles and of different types of cytoplasmic inclusions. In electron microscopical studies large numbers of both... | 174,523 | [
-0.006285745,
-0.0371002,
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0.09381466,
0.05038048,
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0.1101387,
0.1502996,
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0.04257383,
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0.2521517,
0.2089327,
0.4258912,
0.6487874,
-0.17308... |
Immunoglobulins, antibodies and inhibitors of parainfluenza 3 virus in respiratory secretions of sheep. | Virus neutralising and haemagglutination inhibiting (HI) activities were monitored in the serum, nasal secretions and tracheo-bronchial secretions of lambs infected with Parainfluenza virus type 3 (PI3). HI activity was found in the secretions of both control and infected lambs, whereas neutralising antibody was found ... | 174,528 | [
-0.2076309,
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0.006316788,
0.07259624,
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0.06475824,
0.121117,
-0.24096... |
[Problems of the electric response audiometry (ERA) during the natural and artificial sleep (author's transl)]. | The investigators carried out threshold determinations on 16 children and 6 adults in wakefulness, under general anaesthesia (we used chloral hydrate anaesthesia) and in sleep (stage II-III and stage REM). Falling asleep (stage I and initial stage of anaesthesia respectively) the latencies of the individual components ... | 174,537 | [
0.0005424833,
0.1436618,
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0.3200749,
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0.3056307,
0.1838868,
-0.1015343,
... |
A comparison of the regulation of pyruvate dehydrogenase in mitochondria from rat brain and liver. | The total activity of pyruvate dehydrogenase in mitochondria isolated from rat brain and liver was 53.5 and 14.2nmol/min per mg of protein respectively. Pyruvate dehydrogenase in liver mitochondria incubated for 4 min at 37 degrees C with no additions was 30% in the active form and this activity increased with longer i... | 174,544 | [
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0.4075774,
0.1012899,
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0.1133737,
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0.3443141,
-0.1829908,
0.2516963,
0.1886844,
0.0162... |
Conversion of thyroxine into tri-iodothyronine by rat liver homogenate. | By using a highly specific radioimmunoassay the formation of tri-iodothyronine by the deiodination of thyroxine was studied in rat liver homogenate. Several observations suggest that the reaction observed is enzymic in nature. Pre-heating the homogenate for 30 min at 56 degrees C completely abolished conversion of thyr... | 174,547 | [
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0.004429216,
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0.2430389,
0.2409306,
0.2454693,
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... |
Proteoglycans of hyaline cartilage: Electron-microscopic studies on isolated molecules. | Proteoglycan monomers from guinea-pig costal cartilage, bovine nasal and bovine tracheal cartilage were observed in the electron microscope after being spread in a monomolecular layer with cytochrome c. The proteoglycan molecule appeared as an extended central core filament to which side-chain filaments were attached a... | 174,551 | [
0.09340854,
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0.08552514,
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0.2905856,
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0.1914646,
0.3625363,
0.04868741,
0.4512832,
0.1445847,
-0.01554167... |
Physicochemical characterization of the four-iron-four-sulphide ferredoxin from Bacillus stearothermophilus. | 1. A stable ferredoxin was prepared from Bacillus stearothermophilus and purified by chromatography on DEAE-cellulose and by electrophoresis. 2. The minimum molecular weight determined from the amino acid composition was about 7900 and this was in reasonable agreement with a value of 8500 determined by polyacrylamide-g... | 174,558 | [
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0.1858846,
0.09250015,
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0.04911944,
0.06449676,
0.08542942,
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0.003393885,
0.2926042,
-0.022228... |
Synchronous digestion of SV40 DNA by exonuclease III. | We have established an optimal condition for the synchronous digestion of SV40 DNA with Escherichia coli exonuclease III. Electron microscopy and polyacrylamide gel electrophoresis were used to obtain accurate measurements on the lengths of DNA before and after exonuclease III digestion. Based on this finding, a new me... | 174,717 | [
-0.132598,
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0.06697268,
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0.04313605,
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0.108632,
0.5099254,
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-0.1505026,
... |
Partial purification and properties of a DNA-binding protein from nuclei of cells infected with polyoma virus. | A DNA-binding protein has been purified from nuclei of 3T3 cells infected with polyoma virus. The assay used to detect this activity measures the amount of double-stranded DNA retained on a nitrocellulose membrane filter in the presence of binding protein. The interaction between DNA and protein is salt dependent and o... | 174,725 | [
-0.1311681,
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0.2019828,
0.3709896,
0.1820519,
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-0.3152317,
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0.1204157,
0.03297438,
0.2592363,
-0.1444781,
-0.2670514... |
Early androgen action in kidney of normal and androgen-insensitive (tfm/y) mice. Changes in RNA polymerase and chromatin template activities. | Intranuclear accumulation of testosterone was compared with early changes in transcriptional events in kidneys from normal female and androgen-insensitive (tfm/y) mice. Following a subcutaneous injection of [3H] testosterone, total nuclear uptake of the steroid was maximal at 30 min and declined to about 40% of the pea... | 174,726 | [
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0.127917,
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0.1652143,
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0.134739,
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-0.06930595,
0.03154697,
0.4694373,
-0.08386654,
-0.20161... |
Inpatients in an accident unit. | A one-year prospective study was undertaken in the 79-bed accident unit of the Bristol Royal Infirmary to define reasons for continuing inpatient care. This showed that, of a consecutive series of 466 patients staying in hospital for over two weeks, 35% lengthened their stay beyond that needed for acute nursing or cont... | 174,774 | [
-0.272047,
0.1370647,
-0.09565397,
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0.1222793,
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-0.4061803,
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0.06357926,
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0.0925737,
-0.3991158,
-0.2041473,
-0.3249377,
-0.1035808,
0.186709... |
Elastogenesis in adenomatoid tumor: histochemical and ultrastructural observations. | An adenomatoid tumor from the round ligament of a 50-year-old woman was studied by light and electron microscopy. Ultrastructurally the tumor was remarkably similar to normal as well as neoplastic mesothelium, thus lending further support to the concept of a mesothelial origin of adenomatoid tumors. Comparative histoch... | 174,801 | [
-0.06422961,
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-0.3836521,
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0.1069815,
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0.3057148,
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0.03076049,
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0.1071975,
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0.113961,
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0.03367825,
0.3478796,
0.02118832,
-0.1205647,
0... |
Induction of liver tumors by aflatoxin B1 in the tree shrew (Tupaia glis), a nonhuman primate. | The epidemiological studies suggest that aflatoxins, the toxic metabolites of the ubiquitous mold Aspergillus flavus, may play a significant role in the evolution of hepatocellular carcinoma in man in certain geographic areas of the world. To ascertain their carcinogenicity in nonhuman primates, we have administered hi... | 174,805 | [
-0.1234791,
-0.2316794,
-0.2970696,
-0.08749626,
0.3931592,
-0.3924586,
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0.1731032,
0.1448934,
-0.07286107,
-0.2777348,
0.08776771,
-0.05728726,
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-0.1310308,
0.3148279,
0.3460986,
-0.1820475,
-0.008835905,
0.7332274,
-0.2311047... |
Distribution of viral glycoprotein gp 69/71 on cell surfaces of producer and nonproducer cells. | The distribution of the viral glycoprotein, gp 69/71, was studied on the cell surfaces of virus-producing and nonproducing cells. gp 69/71 was distributed evenly on cell membranes and on viral membranes of cells producing murine leukemia virus. gp 69/71 was distributed uniformly on cell membranes of thymocytes from NZB... | 174,807 | [
-0.1364889,
-0.1093735,
-0.4967925,
0.01467403,
0.2588144,
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0.1174689,
0.1606941,
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0.1804842,
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-0.03919904,
0.1563937,
0.1122973,
0.1451849,
0.1590231,
0.2928244,
-0.0568022,
... |
Effect of neuraminidase and papain treatment on lectin-induced agglutination of Novikoff tumor cells and assay of lectin receptor activity of the glycopeptides released from the cell surface by papain. | Lectins, plant proteins that bind specific saccharide determinants, have been utilized to examine the effect of neuraminidase digestion on the structure and/or expression of oligosaccharide moieties present at the periphery of Novikoff ascites hepatoma cells. Five lectins were utilized: concanavalin A (Con A), specific... | 174,811 | [
0.2061292,
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0.1627894,
0.621564,
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0.00007558255,
0.03613878,
0.1887828,
0.671227,
0.2107809,
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0.1131276,
-0.4347749,
0.02091713,
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0.08436759,
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0.107426,
0.2404792,
-0.3156216,
0.1... |
Croton oil- and benzo(a)pyrene-induced changes in cyclic adenosine 3':5'-monophosphate and cyclic guanosine 3':5'-monophosphate phosphodiesterase activities in mouse epidermis. | The topical application of croton oil, benzo(a)pyrene, acetic acid, and 12-O-tetradecanoyl-phorbol-13-acetate to mouse skin caused an increase in the activity of epidermal low-affinity cyclic adenosine 3':5'-monophosphate (cyclic AMP) phosphodiesterase. The increase was most pronounced with croton oil, began between 4 ... | 174,815 | [
-0.1392082,
-0.2232816,
-0.1766662,
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0.551751,
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-0.2238059,
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0.1536777,
0.04757752,
0.05111685,
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0.02785015,
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0.1787628,
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-0.1186989,
0.1320399,
0.1476381,
0.6897834,
0.2548166,
-0.1538474... |
Brain tissue transplanted to the anterior chamber of the eye. 4. Drug-modulated transmitter release in central monoamine nerve terminals lacking normal postsynaptic receptors. | Small pieces of fetal rat brain selected to contain a high number of noradrenaline (NA), dopamine (DA), or 5-hydroxytryptamine (5-HT) neuroblasts were transplanted to the anterior chamber of the eye of adult rats. The sympathetic ground plexus of the host iris was removed by superior cervical ganglionectomy so that tra... | 174,817 | [
-0.3295736,
-0.4786086,
-0.2509917,
-0.139359,
0.350597,
-0.346063,
-0.1689744,
-0.06352406,
-0.04130955,
0.3082133,
0.2448602,
-0.06812476,
0.2104701,
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-0.7456528,
-0.2565754,
0.08906269,
0.2205811,
0.61141,
0.1929619,
0.01149127,
-0... |
[The peroxisomes of Triturus cristatus (amphibian, urodele) adrenal cortex cells: peroxisome number as a function of steroidogenic activity]. | Peroxisomes are scarce in the poorly active interrenal cells of hypophysectomized animals; their number increases drastically in cells which are stimulated by corticotrophic factors. A precise correlation appears thus to exist between the steroidogenic activity of the interrenal cells and the number of peroxisomes in t... | 174,829 | [
0.2209668,
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0.2238325,
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0.2363788,
0.1680026,
-0.02982739,
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0.0242749,
-0.06989019,
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-0.2190149,
-0.0587695,
-0.01184599,
0.338548,
0.2412502,
-0.026914,
0.05699252,
... |
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