title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Acrylamide poisoning. | A small epidemic of acrylamide poisoning amongst workers in the construction industry is described. The clinical features of this condition are reviewed and two cases are described in which residual neurological problems persisted for over 1 year. The literature on acrylamide poisoning is reviewed and it is recommended... | 195,278 | [
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[261 cases of bronchopulmonary cancer detected by radiophotography]. | In Bucharest, district 6, of the 1 151 313 radiophotographies performed, 261 revealed bronchopulmonary cancers (22.6 per 10 000) of which 73% males and 27% females, the 50--70 years age group being the most affected (181 cases, i.e. 70%). The 85% deaths occurred within 2 years after detection. In 68% (177 cases) cancer... | 195,323 | [
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Three hypolipidemic drugs increase hepatic palmitoyl-coenzyme A oxidation in the rat. | Male rats treated with clofibrate, tibric acid, or Wy-14,643 show an 11- to 18-fold increase in the capacity of their livers to oxidize palmitoyl-coenzyme A. This provides a plausible biochemical mechanism for the action of these hypolipidemic drugs in reducing lipid concentrations in the serum. | 195,342 | [
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1,25-dihydroxycholecalciferol and parathormone: effects on isolated osteoclast-like and osteoblast-like cells. | The actions of 1,25-dihydroxycholecalciferol [1,25-(OH)2D3] and parathormone, both effective bone-resorptive agents in vivo and in vitro, were tested on CT (osteoclast-like) and PT (osteoblast-like) bone cells maintained in culture. Both agents stimulated acid phosphatase activity and hyaluronate synthesis in the CT ce... | 195,343 | [
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Endodermal sinus tumor of the anterior mediastinum. | An endodermal sinus tumor presenting as a lobulated anterior mediastinal mass in a 20-year-old white man is reported. The clinical implications, histology, and origin of this rare germ cell tumor are discussed. The invasive nature of this highly malignant neoplasm prevented complete surgical resection. | 195,346 | [
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Pseudomonas endocarditis: cure with carbenicillin and polymyxin B. | A case of Pseudomonas endocarditis cured with carbenicillin and polymyxin B is described. Initially, this patient was considered a medical treatment failure when a full course of carbenicillin and gentamicin failed to effect a cure. The importance of monitoring therapy with appropriate laboratory tests is stressed. | 195,349 | [
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[Specific and unspecific immune stimulation in recurrent herpes simplex]. | According to the present state of our knowledge the clinical picture of the recurrent herpes simplex and the recurrent stomatitis aphthosa is due to a weakness of the immune defense. It cannot be decided yet if it is but a quantitative weakness or if it is a special form of disturbance in the permeation, which allows t... | 195,407 | [
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Infectious mononucleosis and mononucleosis syndromes. | Infectious mononucleosis (IM) and cytomegalovirus (CMV) mononucleosis are caused by a primary infection with related viruses, Epstein-Barr virus (EBV) and CMV. Despite the similarity of clinical manifestations, basic differences exist: (1) The heterophil antibody (HA) response is absent in CMV mononucleosis, whereas it... | 195,404 | [
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Cytostatic efficacy of DNA-complexes of adriamycin, daunomycin and actinomycin D. I. Comparative studies in Novikoff hepatoma, human mammary carcinoma cells and human leukemic leukocytes. | Inhibitory effects of adriamycin, daunomycin, actinomycin D and of the related DNA-complexes on DNA and RNA synthesis were compared by precursor uptake studies in Novikoff hepatoma cells, human mammary carcinoma cells and human leukemia cells. In addition, nuclear RNA labelling profiles were analyzed in human acute leu... | 195,410 | [
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African green monkey fibroblast actin morphology during SV40 infection. | Monkey skin fibroblasts were infected with simian virus 40. Cells that exhibited the viral tumor antigen were found to retain the normal morphology of actin filaments up to six days after infection. However when cells were transformed in terms of focus formation they had lost the normal actin morphology. | 195,416 | [
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Ultrastructural study of the vacuoles in the peripheral lymphocytes in juvenile amaurotic idiocy. Juvenile form of generalized ceroid lipofuscinosis. | Lymphocytes of the peripheral blood of 31 patients with juvenile amaurotic idiocy (juvenile form of ceroid lipofuscinosis) were examined with the electron microscope. In all cases, intracytoplasmic clear vacuoles were present, containing round hollow, fingerprint and highly electron dense structures. The combination of... | 195,436 | [
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Statistical analysis of factors affecting survival after glioblastoma multiforme. | Statistical evaluation of 71 cases (adults) of histologically confirmed supratentorial surgically treated glioblastoma multiforme seen during the period 1958 to 1973 revealed that the state of calcification as determined by roentgenography and the histological appearance of the neoplasm appeared to have a relationship ... | 195,443 | [
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Sensitive fluorimetric assay for serum angiotensin-converting enzyme with the natural substrate angiotensin I. | A simple, rapid, highly sensitive and reproducible fluorimetric assay for angiotensin-converting enzyme in untreated serum using the natural substrate based on a similar assay with hippuryl-L-histidine-L-leucine is described. Angiotensin I (0.2 mM in 0.1 M potassium phosphate-30 mM NaCl, pH 7.5; 37 C) is converted to a... | 195,458 | [
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Bacterial flora of stored human donor corneas after antibiotic treatment. | In 100 out of 122 eyes obtained at autopsy, bacteria could be cultured in swabs taken from the conjunctivae. After individual storage of the excised corneas at +4 degrees C in a modified tissue culture medium containing 100 microgram/ml Gentalmicin, in 18 culture specimens there was still some growth of microorganisms.... | 195,488 | [
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Cutaneous bullae in coma due to poisoning. An association with deep seated ischaemic lesions of muscle. | A deeply unconscious patient may develop ischaemia in those soft tissues subjected to pressure. Pressure on the skin may give rise to blistering which is reversible. Pressure on the limbs may precipitate irreversible ischaemia of the muscles and nerves unless a fasciotomy is performed. | 195,489 | [
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Immunoglobulin G subclass [IgG and IgG(T)] interaction with the P26 group specific antigen of equine infectious anemia virus: immunodiffusion and complement-fixation reactions. | Isolated equine immunoglobulin (Ig)G(T) antibodies to equine infectious anemia virus P26 antigen did not precipitate with antigen when the ratio of antibody to antigen was high. However, at lower ratios of antibody to antigen precipitation occurred. In addition, complement-fixation by IgG and P26 antigen was inhibited ... | 195,493 | [
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Transmission of non-A, non-B hepatitis. | In studies conducted in the early 1950s, sera from six asymptomatic blood donors, implicated in the transmission of viral hepatitis, were inoculated into 10 to 20 volunteers each. Five of these "implicated" donor sera transmitted clinically apparent hepatitis to the recipients. The stored serum samples from these studi... | 195,505 | [
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Variations in adrenocortical responsiveness during severe bacterial infections. Unrecognized adrenocortical insufficiency in severe bacterial infections. | Plasma cortisol levels and their response to .25 mg synthetic A.C.T.H. (Cortrosyn) were studied in 26 septic patients. Four (15.4%) of these patients appeared to have greatly increased adrenocortical activity with plasma cortisol levels averaging 65.4 +/- 14.8 microgram/dl (normal = 8-18 microgram/dl. All four of these... | 195,542 | [
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Psychoses precipitated by psychotomimetic drugs. A follow-up study. | Fifteen patients who developed prolonged psychotic reactions following psychotomimetic drug use (probably primarily LSD) were followed up 1.9 to 5.8 years later. Two patients had committed suicide. Approximately half of the patients had a relatively good outcome and half did poorly. Aspects of the initial clinical pict... | 195,549 | [
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Cytochemical studies of respiratory enzymes in carcinoma of the cervix uteri after irradiation by radium and cobalt 60. | Enzymological studies of succinic dehydrogenase and cytochrome oxidase were made on human squamous cell carcinoma of the cervix uteri before, during and after radiation therapy by radium and 60CO. The enzymatic activities of the two enzymes were higher in cells of stage III than in the corresponding cells of stage II. ... | 195,550 | [
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Elimination of Proteus mirabilis 51Cr endotoxin from the liver in rats. | Using isotope methods, elimination of the endotoxin of Proteus mirabilis labeled with chromium (CrEPm) from the liver of rats was studied. The following studies were carried out: intravital exploration of the liver with a scintillation probe, measurements of radioactivity of organs and excreted urine and stools, scrint... | 195,551 | [
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Aldehyde dehydrogenase in 2-acetamidofluorene-induced rat hepatomas. Ontogeny and evidence that the new isoenzymes are not due to normal gene de-repression. | The pre- and post-natal ontogeny of Sprague-Dawley rat liver aldehyde dehydrogenase [aldehyde-NAD(P)(+) oxidoreductase, EC 1.2.1.5] is described. At no time in its ontogenetic development does normal liver aldehyde dehydrogenase exhibit any of the characteristics of a series of unique aldehyde dehydrogenases that can b... | 195,578 | [
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A comparison of membrane components of normal and transformed BALB/c cells. | Membrane glycolipids, glycoproteins, and surface proteins of normal and transformed BALB/c cell lines have been compared. Several virally and spontaneously transformed cell lines showed differences in membrane components compared to normal A31 cells. These differences consisted of increased amounts of simpler gangliosi... | 195,596 | [
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Involvement of NAD in induced synthesis of colicin E1. | Escherichia coli K-12 nadC13 (ColE1) was starved for nicotinic acid and cellular NAD levels decreased to less than 10% of the normal. Under these conditions, induction of colicin E1 synthesis decreased to about 1% of the normal value, while 30% of the total protein synthesis remained intact. Addition of nicotinic acid ... | 195,612 | [
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The role of carbohydrate in the glycoenzyme invertase of Neurospora crassa. | Data obtained concerning the carbohydrate moieties of the glycoenzyme invertase (EC 3.2.1.26, beta-D-fructofuranoside fructohydrolase) from Neurospora crassa were consistent with a linkage of some carbohydrate chains by O-glycosidic bonds to serine and threonine residues; the possibility of N-glycosylamine linkage of s... | 195,681 | [
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Cellular immunity to herpes simplex virus in man. VII. K-cell activity to HSV1 infected target cells in disease. | Herpes simplex virus-infected target cells, sensitised with antiviral antibody can be lysed by non-immune human lymphocytes (K-cells). This antibody dependent cell mediated immunity (ADCC) is a very efficient technique for destroying foreign target cells and may play a role in maintaining the localization of recurrent ... | 195,708 | [
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Biological effects of inhibition of guanine nucleotide synthesis by mycophenolic acid in cultured neuroblastoma cells. | Mycophenolic acid, an inhibitor of inosinate dehydrogenase, had cytostatic and cytotoxic effects on cultured neuroblastoma cells. Proliferation was inhibited by 50% when cells were incubated with 0.07 micrometerM mycophenolic acid, and cell viability was reduced by 83% when cells were treated with 10 micrometerM mycoph... | 195,725 | [
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Ultrastructure of the respiratory epithelium in the lungs of the tortoise, Testudo graeca. | The respiratory epithelium in the lungs of the tortoise (Testudo graeca) has been studied by electron microscopy. The epithelium consists of a mosaic of two different cell types (here called "pneumonocytes"). Type I pneumonocytes are roughly squamous and possess attenuated flanges of cytoplasm which extend over the sep... | 195,734 | [
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0.0805359... |
A simple and sensitive method for estimating the concentration and synthesis of 5-phosphoribosyl 1-pyrophosphate in red blood cells. | A method is presented for the determination of 5-phosphoribosyl 1-pyrophosphate (PRPP), which is based on the release of 14CO2 from [carboxyl-14C]-orotic acid by the consecutive action of orotate phosphoribosyltransferase and orotidine-5'-monophosphate decarboxylase. The assay is simpler and less time-consuming than mo... | 195,752 | [
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Lipoprotein concentrations in untreated adult onset diabetes mellitus and the relationship of the fasting plasma triglyceride concentration to insulin secretion. | Plasma lipoprotein concentrations in 64 untreated adult onset diabetics were compared to the lipoprotein levels found in non diabetics. No significant difference was found. The relationship of the fasting plasma triglyceride concentration to the plasma immunoreaction insulin response to 50 g glucose orally was investig... | 195,754 | [
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The effect of apomorphine and clonidine on locomotor activity in mice after long term treatment with haloperidol. | 1. Mice were given haloperidol (approximately 3 mg.kg-1 day-1) or vehicle for 21 days and then withdrawn from the drug. All tests were performed 4 days after withdrawal. 2. Haloperidol treated mice (premedicated with reserpine plus alpha-methyl-p-tyrosine) displayed an increased locomotor response to apomorphine and to... | 195,762 | [
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0.3204075,
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Hexoprenaline: a review of its pharmacological properties and therapeutic efficacy with particular reference to asthma. | Hexoprenaline1, N,N-[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl] hexamethyl-enediamine, sulphate is a selective beta2-adrenoreceptor agonist which is active in man as a bronchodilator by the oral or intravenous routes and by inhalation. It is indicated for use in the treatment of bronchospasm associated with obstructive ai... | 195,789 | [
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Evidence that catecholamines are not the afferent transmitter in the cochlea. | Beta-receptor blocking agents (practolol, propranolol) and alpha-receptor blocking agents (phenoxybenzamine, phentolamine), when applied intracochlearly do not eliminate the afferetn discharges or compound action potential of the cochlear nerve. Under the assumption that the drugs used reach the synaptic site, it is th... | 195,827 | [
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0.2111967,
0.23572... |
The activity of Escherichia coli DNA-dependent RNA polymerase on DNA templates of different origin. The effect of cAMP. | DNA isolated from different T phages served as a better template for the synthetic activity of unmodified Escherichia coli RNA polymerase in the in vitro system than did the host DNA. cAMP significantly stimulated the activity of such a preparation of RNA polymerase. The stimulation was more pronounced with the host DN... | 195,876 | [
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0.121... |
Serum hormone levels and tissue metabolism in pair-fed lean and obese Zucker rats. | Obese Zucker rats were either pair-fed to their lean litter-mates or fed ad lib, to determine the effect of hyperphagia on serum hormone levels and tissue metabolism as indicated by enzyme activities and in vitro metabolite flux. Hyperphagia was shown to be non-essential for the elevation in serum insulin and suppressi... | 195,881 | [
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Release of periplasmic enzymes from Escherichia coli by penicillin-ethylenediaminetetraacetate treatment. | When Escherichia coli cells are converted into spheroplasts by penicillin treatment, none of the periplasmic enzymes is released. However, incubation of the penicillin-induced spheroplasts in a medium containing ethylenediaminetetraacetic acid caused the release of endonuclease I and cyclic phosphodiesterase but not of... | 195,932 | [
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... |
Binding of viral glycoprotein mRNA to endoplasmic reticulum membranes is disrupted by puromycin. | Previous studies showed that the glycoprotein (G) of vesicular stomatitis virus is synthesized in association with the endoplasmic reticulum (ER) membrane and that all G mRNA co-fractionates with ER membrane. Here, we show that treatment of infected cells with puromycin results in dissociation of G mRNA, and presumably... | 195,964 | [
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Maintenance of viability and comparison of identification methods for influenza and other respiratory viruses of humans. | A comparison of Hanks balanced salt solution, veal infusion broth (VIB), and charcoal viral transport medium for maintaining viability of type A influenza virus indicated approximately equal survival of virus on all three media at -70 and 4 degrees C, whereas at 25 degrees C virus survived best in VIB. VIB supplemented... | 195,979 | [
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... |
Metabolic effects of diphosphonate in primary hyperparathyroidism. | Six patients with primary hyperparathyroidism (PHPT) and one with squamous cell carcinoma of the esophagus with parathyroid hormone excess received disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) at a daily dose of 20 mg/kg orally. During treatment, the decrease in urinary calcium, total urinary hydroxyproline, and ... | 195,983 | [
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0.05857496,
0.4244435,
0.1970737,
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0... |
Post-ischaemic paraesthesia in pellagrins. | A quantitative assessment of post-ischaemic paraesthesiae has been made in 50 pellagrins and 20 healthy identical controls. The results show a higly significant diminution of the paraesthetic response in pellagrins. In pellagrins having peripheral neuropathy the depression of paraesthesiae was more marked than in those... | 196,050 | [
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... |
Genetic studies of the Fv-1 locus of mice: linkage with Gpd-1 in recombinant inbred lines. | Multiple recombinant inbred lines, derived from crosses between strains permissive to N-tropic murine leukemia viruses (Fv-1n) and strains permissive to B-tropic murine leukemia viruses (Fv-1b), have been characterized as to Fv-1 genotype and other chromosome 4 markers, including the closely linked hexose-6-phosphate d... | 196,096 | [
-0.174697,
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... |
Interaction of polyoma and mouse DNAs. IV. Time course and extent of integration of polyoma DNA into mouse DNA during lytic infection. | The time course of covalent binding of polyoma viral DNA to mouse DNA was followed in mouse embryo cells that had been grown prior to infection in the presence of 5-bromodeoxyuridine. Density-labeled (HL) mouse DNA was separated from free polyoma DNA by CsCl isopycnic centrifugation. Polyoma DNA sequences present in HL... | 196,109 | [
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Encephalomyocarditis virus RNA. II. Polyadenylic acid requirement for efficient translation. | Differentially polyadenylated subpopulatons of encephalomyocarditis (EMC) viral RNA were isolated by affinity chromatography on oligodeoxythymidylic acid-cellulose. Translation of these RNA fractions in several in vitro protein-synthesizing systems, isolated from Ehrlich ascites tumor cells, demonstrated that poly(A)+E... | 196,111 | [
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... |
Heteroduplex study of the sequence relations between RD-114 and baboon viral RNAs. | The regions of sequence homology and nonhomology between the RNA genomes of RD-114 and baboon endogenous type C viruses have been mapped by an electron microscope heteroduplex study. Short complementary DNA (cDNA) copies (approximately 150 to 200 nucleotides in length) of RD-114 RNA were prepared by an endogenous synth... | 196,112 | [
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0.2199717,
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Surgical management of vagal chemodectomas. | Vagal chemodectomas (tumors of the vagal glomus body) are histologically benign and insensitive to radiation therapy. Unless properly managed, these tumors may become life-threatening because of their eventual impingement on surrounding structures, particularly contents of the cranial vault. Patients with chemodectomas... | 196,145 | [
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... |
A cluster of Epstein-Barr-virus-associated American Burkitt's lymphoma. | We investigated four patients in whom histologically confirmed Burkitt's lymphomas developed during a one-year period. They were young adults living within 50 km of each other in a rural area of Pennsylvania. Two patients were related by marriage, but there was no contact with or between the other two. Although the maj... | 196,197 | [
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Lack of detectable secretion of ACTH from pituitary homografts of pars intermedia. | Hypophysectomized rats bearing grafts of the pars intermedia (PI) in the kidney capsule for 20 days did not show adrenal weights significantly different from those of hypophysectomized controls. Plasma corticosterone was undetectable in the grafted rats, even after the injection of lysine-vasopressin or histamine. On t... | 196,231 | [
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... |
Inhibition of DNA synthesis in cultures of 3T3 cells by isolated surface membranes. | When added to a sparse culture of 3T3 cells, a surface membrane-enriched fraction from 3T3 cells inhibited the rate of DNA synthesis in a time- and concentration-dependent manner. The membrane preparation had no effect on the rate of DNA synthesis of simian virus 40-transformed 3T3 cells. A similar membrane preparation... | 196,284 | [
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The intestine as a source of apolipoprotein A1. | The major apoprotein of rat mesenteric lymph chylomicrons has been isolated and characterized and shown to be identical to apoprotein A1 (apo A1) isolated from serum high density lipoprotein (HDL). During intestinal lipid absorption, active synthesis of apo A1 was demonstrated by radioactive amino acid incorporation in... | 196,292 | [
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... |
Cellular metabolic control by chemical modification of cell membrane. | Various reagents used in the chemical modification of amino- and carboxy-groups of proteins, and of carbohydrates of glycoproteins and glycolipids, inhibit respiration in ascites tumor cells concomitant with release of potassium ion from those cells. The respiratory activity of washed ascites tumor cells is increased b... | 196,300 | [
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0.0008443226,
0.1465373,
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A comparative evaluation of a case of cystosarcoma phylloides: ultrasound, xeroradiography and thermography. | The results of xeroradiography, thermography, and ultrasonic gray scale echography in a case of cystosarcoma phylloides are presented. Echography better described the lesion than the other techniques. Gray scale echography displays the infrastructure of the breast tissues and differentiates between types of soft tissue... | 196,315 | [
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0.1185931,
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0.3881599,
0.1856964,
-0.08711669... |
Chromatographic patterns of prostaglandins using different lots of silicic acid. | The chromatographic patterns of prostaglandin E2 chromatographed on various lots of silicic acid are presented. Two lots of Mallinckrodt silicic acid tested give totally unsatisfactory separation of PGE2. Sigma silicic acid SIL-R gives better separation than any of the Mallinckrodt lots tested. Increasing the size of t... | 196,316 | [
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0.3025671,
0.2326364,
0.02325098,
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-0.1039908,... |
Cyclic Amp and the release of antral gastrin. | The isolated, vagally innervated antral pouches in anesthetized dogs were irrigated with 095% acetylcholine chloride (Ach) or a 0.4 M mixture of non-essential amino acids (AA), or distended at 30 cm H2O pressure. In addition,2-deoxy-D-glucose (2-DG) was administered intravenously. Significant increases in antral venous... | 196,327 | [
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0.1344629,
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... |
Thyroid hormone action: the mitochondrial pathway. | The subcellular compartments have been investigated to compare proteins capable of binding triiodothyronine and thyroxine; specific binders have been found in cytosol, nuclei, and mitochondria from rat liver and kidney. The binding protein from the inner mitochondrial membrane had the highest association constant (grea... | 196,334 | [
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0.3033886,
0.4390319,
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0.... |
Acute haemorrhagic conjunctivitis in Hong Kong 1971-1975. | Acute haemorrhagic conjunctivitis occurred in epidemic in Hong Kong in 1971 and 1975 respectively. Two picornaviruses, the Enterovirus type 70 and an antigenic variant of Coxsackie virus type A24, were isolated during the 1971 outbreak, while only the latter virus was detected in the 1975 outbreak. In 1972 and 1974, sp... | 196,351 | [
-0.1868866,
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-0.3102671,
-0.01476566,
0.07296715,
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0.5231902,
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0.2020428,
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0.5020574,
-0.3121893,
... |
[Analysis of substances issuing from Zajdela ascitic hepatoma cells after exposure to UV radiation of different wave-lengths. I. Relationship to dose]. | The release of substances from the Zaidela ascitic hepatoma cells after irradiation with physiological doses of short-wave (254 nm) and long-wave (300-380 nm) UV light (far and near UV light) has been studied spectrophotometrically. Within the range of 200-520 nm, the absorption spectra of releasing substances show max... | 196,372 | [
0.007572049,
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0... |
Tissue-cultured head and neck tumors: their use in in vitro assays of immune response. | Samples of 35 tumors from the head and neck region (25 squamous cell, 2 basal cell, 5 parotid, 3 melanoma, and 1 lymphosarcoma) were cultured after dispersement with either trypsin or collagenase treatment. Growth was established in 14 (40%). Cultured tumor cells were then used as target cells in in vitro assays of pat... | 196,378 | [
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0.5244278,
0.7356219,
0.1063512,
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Electron microscopic study of signet-ring cells in diffuse carcinoma of the human stomach. | The signet-ring cells seen in gastric carcinoma of the diffuse type were studied by light and electron microscopy. A classification of these cells into Types A, B and C was developed, based on intracellular mucous granules, nuclei and organelles, and be reactions to PAS and Alcian-blue staining. The gradual transition ... | 196,391 | [
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0.3925811,
0.02672186,
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[Stimulating effect of glucagon and theophylline on the activity of rat liver betamine-homocysteine-methyltransferase. Role of cyclic adenosine-3',5'-monophosphate]. | Effect of glucagon, theophylline, NaF and cyclic 3',5'-AMP on the activity of betaine-homocysteine-methyl transferase (BHMT) was studied in homogenates of rat liver tissue. Intraperitoneal administration of theophylline into adult rats increased the BHMT activity in liver tissue. After administration of theophylline th... | 196,408 | [
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0.3178579,
0.5088071,
0.1478678,
0.02864983,
... |
Effect of insulin and adrenaline on cyclic AMP in the diaphragm of normal and diabetic rats. | The effects of insulin and adrenaline on cyclic AMP (cAMP) levels in diaphragms of normal, streptozotocin-diabetic and insulin-treated diabetic rats were studied. Adrenaline caused a biphasic rise in cAMP with peak values of cAMP within the first few minutes. Diaphragms of diabetic rats showed an increased responsivene... | 196,469 | [
-0.1181724,
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0.05246843,
0.1698519,
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0.25899... |
In vitro temporal cAMP and cortisol responses to ACTH by the normal human adrenal gland. | The in vitro temporal cAMP and cortisol responses of normal human adrenocortical tissue to ACTH were evaluated. ACTH stimulated rapid increased in cAMP levels and cortisol output, however, significantly increased cAMP levels preceded output only at the higher ACTH doses studied. Cortisol output plateaued with ACTH (10-... | 196,470 | [
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0.06249307... |
T-typing of group A streptococci from clinical specimens: restriction of the number if implied M types in each T-pattern by tests for opacity factor and nicotinamide adenine dinucleotide glycohydrolase. | 117 group A streptococci, consecutively isolated from routine throat swab cultures, were T-typed and further characterized according to their enzyme reactions. The results of typing with two different commercial kits of anti-T sera showed good agreement. 89 per cent of the strains were typable by either of these kits. ... | 196,480 | [
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Macrophage migratory dysfunction in cancer. A mechanism for subversion of surveillance. | There is considerable evidence to suggest that macrophages participate in host resistance to the development and spread of cancer. We have, therefore, studied monocytemacrophage function in humans and animals with neoplasms. Approximately 60% of patients with various types of cancer were found to have abnormal monocyte... | 196,506 | [
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0.09553349,
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Renin release and pressor response to renal arterial hypotension: effect of dietary sodium. | Changes in plasma renin activity (PRA) and mean arterial pressure (MAP) produced by renal arterial hypotension were studied in conscious, adrenalectomized dogs maintained on low-, normal-, or high-Na diet during constant steroid replacement therapy. In animals maintained on a low-Na diet, reduction of renal perfusion p... | 196,509 | [
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... |
Involvement of cAMP-dependent protein kinase in the regulation of heart contractile force. | The effects of perfusate epinephrine, 1-methyl-3-isobutylxanthine, calcium, and filling pressure were investigated in the perfused working rat heart. Epinephrine produced a rapid increase in cAMP, in the protein kinase activity ratio, and in active phosphorylase. These effects preceded the increase in contractile force... | 196,511 | [
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... |
Introductory studies on metabolism of free glucose in aqueous extracts from smooth muscles of the stomach of geese and ducks. | Aqueous extracts from smooth muscles of the stomachs of geese and ducks contain enzyme systems which not only oxidize free D-glucose, but also determine its further metabolism. The successive metabolites are probably 1,5-D-gluconolactone and 2-ketogluconic acid, and the final product is either pyruvic acid of alpha-ket... | 196,568 | [
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Further studies on human enteric coronaviruses. | Comparisons were made between human enteric coronaviruses and the enteric coronaviruses of pigs and calves by negative staining. Examination of human intestinal organ culture fluids at various time intervals after inoculation with the human enteric coronavirus showed increasing numbers of particles in the fluids. Thin ... | 196,571 | [
-0.2049091,
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0.05853318,
... |
Analysis of the structure of human papilloma virus DNA. | Human papilloma virus DNA has been examined for heterogeneity by electron microscopy, reassociation kinetics, and restriction endonuclease digestion. No heterogeneity in contour length was detected. The reassociation rate of papilloma DNA isolated from pooled warts was consistent with that expected for a homogeneous, u... | 196,580 | [
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... |
A method for characterizing subgroups and related survivals in cancer patients. Application to brain tumors. | It has long been known that if the probability of dying of a given cancer remains constant over time, the logarithmic plot of survival of a group of patients with that cancer will be a straight line. More frequently, however, the probability of dying varies with time and the logarithmic survival plot is a curve. We bel... | 196,583 | [
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Abrupt memory loss associated with thalamic tumor. | We report a case in which glioma with apparent major involvement of the right thalamus was manifested initially solely by abrupt onset of severe impairment of both recent and moderately remote memory. Distracting stimuli plays a role in prevention of consolidation of memory. | 196,584 | [
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0.07197709,
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Systems simulation: theory of monosynaptic transfer between neuron populations. | This paper presents a theory for the input-output transformation involved in diffuse monosynaptic activation in a neural tissue or organ system of one population of neurons by another. Main findings are: (1) highly diffuse monosynaptic linkages act very much like filters, selectively sensitive to synchronized clusters ... | 196,588 | [
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0.0234816,
... |
The synthesis of tritium-labelled human corticotropin of high specific radioactivity. | Human [[3,5-3H2]Tyr23]corticotropin-(1-39)-nonatriacontapeptide of specific radioactivity 25.2 Ci/mmol, identical with unlabelled human corticotropin by several criteria, was prepared via the fully protected di-iodotyrosine compound. The latter was synthesized by classical procedures. | 196,594 | [
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Sulphated acid mucopolysaccharides in SV40-transformed human cells from normal and mucopolysaccharidosis patients. | Lines of fibroblasts have been established from normal individuals and from patients diagnosed as suffering from one of the mucopolysaccharidoses or mucopolysaccharide-storage diseases. Transformation of these lines with SV40 virus has been found to reduce their capacity to secrete sulphated mucopolysaccharides into th... | 196,610 | [
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... |
Role of lamellar bodies in the biosynthesis of phosphatidylcholine in mouse lung. | 1. A lamellar body-enriched fraction was isolated from whole lung homogenates of mouse lung and its contamination with microsomes, mitochondria, and cytosol protein assessed by marker enzyme analyses. 2. By measuring the activity of cholinephosphotransferase (EC 2.7.8.2) in varying amounts of microsomes in the presence... | 196,660 | [
-0.1676104,
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0.1754599,
0.2293395,
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Cyclic GMP-dependent and cyclic AMP-dependent protein kinases, protein kinase modulators and phosphodiesterases in arteries and veins of dogs. Distribution and effects of arteriovenous fistula and arterial occlusion. | Possible involvement of cyclic GMP-dependent and cyclic AMP-dependent protein kinases, protein kinase modulators and cyclic nucleotide phosphodiesterases in functions of vascular tissues were investigated in the dog. All of the above activities, localized in the smooth muscle-rich inner layer of the blood vessels, were... | 196,667 | [
-0.1215647,
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0.1841984,
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0... |
Effects of calcitonin and parathyroid hormone on the metabolism of chondrocytes in culture. | Rabbit articular chondrocytes in suspension culture synthesize Type II collagen [3alpha1(II)] in the absence of extracellular Ca2+ and Type I collagen [2alpha1(I) - alpha2] in the complete medium. As a result of pre-treatment in monolayer culture with calcitonin or parathyroid hormone in the complete medium, an influx ... | 196,669 | [
-0.189469,
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0.3016835,
0.5628806,
0.1111962,
-0.09924929,... |
[Investigation of lipid-exchange lipoproteins from rat liver and hepatoma 27]. | A phospholipid exchange lipoprotein from the postmicrosomal supernatant of rat hepatoma 27, which stimulated in vitro the exchange of sphingomyelin between mitochondria and microsomes, was found. Sphingomyelin is incorporated into the mitochondria under incubation of this complex with rat liver mitochondria (in which s... | 196,684 | [
-0.2555681,
-0.2249468,
-0.2576995,
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0.1601098,
0.04643384,
0.1768657,
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0.0643807... |
[Study of the relationship between the glucocorticoid function of the adrenal cortex and blood lipoproteins]. | Single administration of hydrocortisone to rats led to elevation in the blood serum of lipoproteins of very low density; and repeated administration - of lipoproteins of very low density, low density and of high density. Lipoproteins with d less than 1.063 g/ml produced an inhibitory action on the production of steroid... | 196,702 | [
0.1424453,
0.0246585,
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... |
[3H]dihydroergocryptine binding in rat brain. | [3H]dihydroergocryptine (DHE) appears to bind to alpha-adrenergic receptor sites in rabbit uterine membranes. We have characterized the binding of [3H]DHE to membranes prepared from rat cerebral cortex. alpha-Adrenergic agents were less potent and dopamine and serotonin, more potent, in displacing brain DHE binding tha... | 196,714 | [
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0.1334053,
0.10993,
0.2875665,
0.05299839,
-0.1... |
Some biochemical effects of 4-deoxy-4-fluoro-D-glucose on Escherichia coli. | The uptake of 4-deoxy-4-fluoro-D-glucose (4FG), without subsequent catabolism, by resting cells of Escherichia coli (ATCC 11775) is 0.06 mg/mg dry weight. In frozen-thawed cells of this organism, 4FG is a substrate for the phosphoenolpyruvate phosphotransferase system with a rate of phosphorylation twice that found for... | 196,727 | [
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0.2018894,
0.1847961,
0.7506269,
-0.327953... |
Hepatocellular carcinoma in a woman on long-term oral contraceptives. | A 32-year-old woman on oral contraceptives for 12 years developed a hepatocellular carcinoma, which resulted in death 15 months after initial diagnosis. The possible association between this malignant hepatic tumor and the long-term use of oral contraceptives is reviewed. | 196,746 | [
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... |
A lack of correlation between 'T' antigen and any particular human chromosome in hybrids made between SV40 transformed human fibroblasts and mouse LMTK cells. | Lines of hybrid cells were established by fusion of mouse LMTK- cells with SV40 transformed human fibroblasts. The lines were examined for the presence of SV40 'T' antigen and the human chromosomes they carried identified by Giemsa banding. No significant correlation could be found between any particular human chromoso... | 196,748 | [
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0.09116577,
0.2039931,
-0.1121746,
-0.1836419,... |
C-type virus particles in the transplantable mouse bladder tumour FCB grown in vitro. | Electron microscopic studies were made on an in vitro cultured cell line obtained from the FCB transplantable murine bladder tumour. The cells exhibited a loss of differentiation compared with solid tumour and the presence of C-type virus particles, many in the process of budding. The possible relation of this virus to... | 196,750 | [
-0.1250641,
0.08419808,
-0.4695571,
0.08601596,
0.2139636,
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0.206221,
0.157381,
0.1574559,
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0.1013857,
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0.3088255,
0.1317053,
0.2286223,
0.1705074,
-0.1055688,
0.15... |
[Cytotoxicity of human T-lymphocytes sensitized by Epstein-Barr virus. Role of HLA antigens at the surface of target cells infected by the virus]. | Peripheral T-lymphocytes from patients with infectious mononucleosis are cytotoxic towards target cells from Epstein-Barr virus-genome carrying human lumphoblastoid lines. Thus, these T-cells appear to be sensitized to viral coded determinants. Daudi cells, that carry EBV-genome, but lack HLA antigens are resistant to ... | 196,780 | [
-0.1317251,
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0.2749048,
0.06187766,
0.2098494,
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0.1448709,
0.1252283,
0.09719452,
0.232017,
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0.005957414,
0.01883996,
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0.08509199,
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0.09830666,
0.6368395,
0.1115995,
-0.3111532,
... |
The composition of low (LDL) and very low (VLDL) density lipoprotein subfractions in type III hyperlipoproteinaemia: comparison with normal subjects. | The lipid and protein composition of very low density lipoprotein (VLDL) and low density lipoprotein (LDL) subfractions (Sf greater than 100, 60--100 and 20--60 VLDL and Sf 10.4--20, 5.7--12 and 3.5--6.5 LDL) in six subjects with type III hyperlipoproteinaemia (HLP) was compared to that of 12 normal subjects. In type I... | 196,790 | [
0.08907726,
0.4060123,
0.07387255,
-0.3008316,
0.3243433,
-0.4859974,
0.3111584,
0.05090823,
0.208903,
0.3598832,
0.1008322,
0.01156256,
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0.2078133,
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0.1016572,
0.06524301,
-0.01807123,
0.044522,
0.1495474,
0.06824223,
0.068... |
An improved bioassay for ACTH determination. | An improved method for the bioassay of ACTH has been developed using short-term culture of adrenal cell suspensions derived from intact rats. Six separate pools of adrenals were used and cells derived from the same pool were compared after acute dispersion and overnight culture. The ED50, defined as the concentration o... | 196,826 | [
-0.02135627,
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0.3187937,
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0.1377949,
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0.3117942,
0.3493237,
-0.05850578,
0.203575... |
Incorporation of the 1-pro-R and the 1-pro-S hydrogen atoms of ethanol into steroids and phosphatidylcholines in vivo. | The transfer of deuterium from chiral 1-monodeuteroethanols to various metabolites formed in the liver was studied in order to investigate the coupling of metabolic reductions to the alcohol dehydrogenase and the aldehyde dehydrogenase reactions. The ethanols were administered to female bile fistula rats for 10 h. The ... | 196,853 | [
-0.2343688,
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0.4447201,
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0.002874627,
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0.2030853,
0.03464505,
0.08891534,
0.1154142,
... |
Impaired responsiveness to the effect of glucagon on plasma adenosine 3':5'-cyclic monophosphate in normal man. | Small doses (10-150 microgram; 3-45 nmol) of glucagon caused a dose-dependent increase in plasma adenosine 3':5'-cyclic monophosphate (cyclic AMP) concentration when injected into man. Infusion of glucagon (75 ng min-1 kg-1) for 2 h into normal subjects resulted in an initial increase in plasma cyclic AMP concentration... | 196,859 | [
-0.2492688,
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0.2734767,
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0.1148174,
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0.1074797,
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0.2341182,
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0.04045812,
0.232774,
0.2583402,
0.1049644,
... |
Search for infectious Epstein-Barr virus-releasing cell lines, with particular reference to a new producer line, NHAd-60. | In a search for infectious Epstein-Barr virus (EBV)-producer cell sources, 36 EBV genome-carrying lymphoblastoid cell lines originating from various sources in Japan were screened. Three cell lines derived from different sources were found to release infectious EBV into the culture fluid. EBV from these 3 lines possess... | 196,968 | [
-0.3623688,
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0.280749,
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0.2668073,
0.3698553,
0.07475994,
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0.1651734,
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0.1361817,
0.2994821,
0.09421882,
0.04130407,
... |
[Limitations in the internistic treatment of ulcerative colitis and Crohn's disease]. | Aetiology of ulcerative colitis and Crohn's disease is unknown. Therefore causal therapy is not possible. Conservative treatment for both diseases is of antiinflammatory, symptomatic and substituting nature. Surgical intervention is indicated if conservative treatment fails or if dangerous complications occur. The righ... | 196,988 | [
-0.04274855,
0.0736279,
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0.2110397,
0.2308291,
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0.03275778,
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0.06699067,
0.01863739,
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0.2660244,
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0.05772121,
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0.1850805,
0.05325191,
0.1230929,
0.09803931,
... |
Immobilized Clostridium perfringens neuraminidase. Substrate cleavage and enzyme release during incubation. | Pure Clostridium perfringens neuraminidase was immobilized on Sepharose 4 B, azido-Sepharose 4 B and controlled pore glass (CPG)- glycophase using different coupling procedures. The immobilized enzyme showed increased stability under various conditions relative to the soluble enzyme. The low release of active enzyme fr... | 196,995 | [
-0.1673506,
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0.09104297,
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0.06406432,
0.1634991,
0.09617591,
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0.1219251,
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0.02077846,
0.08146907,
0.004524352,
0.5867216,
0.310054,
-0.1536866,
... |
Investigations into the determination of the cytotoxicity of quartz dust by physical methods. | The methods of thermally stimulated luminescence (t.s.l), thermally stimulated exoelectron emission (t.s.e.e.), electron spin resonance (e.s.r), and infrared spectroscopy (i.r.) have been used to investigate whether the specific cytotoxic activities of SiO2 dust of various origins can be attributed to physical paramete... | 197,003 | [
-0.07497466,
0.04231894,
0.03775328,
-0.0133723,
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0.01074843,
0.1772549,
0.2234123,
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0.03143782,
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-0.4533805,
-0.02863066,
0.197385,
0.3648396,
0.3002209,
0.4528923,
-0.1457018,
... |
Evidence for a mouse pathogenicity locus in certain temperature-sensitive mutants of foot-and-mouth disease virus. | Serial tissue culture passaging of three foot-and-mouth disease temperature-sensitive mutants demonstrated the stability of their temperature sensitivity and mouse avirulence characteristics. Recovery of mouse-virulent temperature-sensitive viruses after passage of the mutants in mice suggested that these were not cova... | 197,007 | [
-0.1783376,
-0.5592659,
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0.08995308,
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0.09199942,
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0.06219194,
0.006884414,
0.05425903,
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-0.1429961,
0.4249143,
0.1290962,
0.1039135,
-0.23345... |
Preparative polyacrylamide gel electrophoresis purification of Clostridium perfringens enterotoxin. | Preparative polyacrylamide gel electrophoresis has been used to purify the enterotoxin of Clostridium perfringens from Sephadex G-100 extracts. Purified toxin of high specific activity was eluted in 1 to 3 h, depending upon the length of the acrylamide gel used. Recovery of biological activity with this technique range... | 197,021 | [
-0.2888561,
-0.03874323,
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0.06600681,
0.126066,
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0.1061697,
0.2170829,
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0.2107712,
0.3577802,
0.0115936,
0.1252172,
0.08400413,
-0.02648351,... |
A rapid method for detecting Junin virus viremia in the guinea pig. | A method for detecting Junin virus viremia in guinea pigs is described. The method consists of infecting BHK-21 cells with blood samples from infected guinea pigs; 48 h later, Junin virus antigens are detected in the cells by indirect immunofluorescence. Application of this technique to patients with Argentine hemorrha... | 197,047 | [
0.1115783,
-0.1194305,
-0.05277891,
0.04433251,
0.08399052,
0.1942548,
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0.1540157,
0.04961551,
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0.3211699,
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0.02723354,
0.0009190069,
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-0.201191,
0.1861923,
-0.05653818,
0.2902763,
0.4098953,
-0.1466094,
-0.08135093... |
Calcium stimulation of plasminogen activator secretion/production by swiss 3T3 cells. | Actively growing Swiss 3T3 cells secret high levels of plasminogen activator which decreases after the cells become confluent. In contrast, simian virus 40-transformed 3T3 cells secrete large amounts of plasminogen activator independent of cell density (Chou, I.-N., O'Donnel, S.P., Black, P.H., and Roblin, R.O. (1977) ... | 197,085 | [
-0.1031662,
-0.3136178,
-0.3101673,
0.08651613,
0.3755936,
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-0.08678089,
0.5120369,
0.07237645,
0.1842838,
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0.3626243,
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-0.1371454,
0.2457977,
0.3265674,
0.402119,
0.00582857,
-0.2730829,
... |
Identification, characterization, and quantitative measurement of cyclic AMP receptor proteins in cytosol of various tissues using a photoaffinity ligand. | Two protein bands, present in cytosol fractions from each of seven rat tissues examined, specifically incorporated 32P-labeled 8-azidoadenosine 3':5'-monophosphate (8-N3-[32P]cAMP), a photoaffinity label for cAMP-binding sites. These proteins had apparent molecular weights of 47,000 and 54,000 on a sodium dodecyl sulfa... | 197,093 | [
-0.02868316,
-0.16096,
-0.1249399,
-0.3291758,
0.4117901,
-0.0424431,
0.001192408,
0.1264856,
0.2912989,
0.09127073,
0.01922957,
0.01408957,
0.3509766,
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0.1098538,
-0.6218255,
-0.05253643,
-0.0309845,
0.02657324,
0.3349686,
0.2393782,
-0.1743219,
... |
Altered absorption spectra of iso-1-cytochromes c from mutants of yeast. | Low temperature (-190 degrees) spectrophotometric recordings were made of mutant strains of the yeast Saccharomyces cerevisiae containing various altered sequences of iso-1-cytochromes c. All mutants with replacements of the tryptophan 64 residue had abnormal Calpha-bands, in which the alpha2-peaks were accentuated to ... | 197,094 | [
-0.04761801,
-0.2142985,
-0.3561756,
-0.01603846,
-0.06175511,
0.03540444,
0.0720455,
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0.5408295,
0.04667372,
0.09713547,
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0.1046496,
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0.1400645,
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0.05977467,
0.189675,
0.4660414,
0.4817145,
0.09918278,
... |
Liposome oxidation and erythrocyte lysis by enzymically generated superoxide and hydrogen peroxide. | Xanthine oxidase, acting on acetaldehyde under aerobic conditions, produces a flux of O2- and H2O2 which attacks artificial liposomes and washed human erythrocytes. The liposomes were peroxidized and the erythrocytes suffered oxidation of hemoglobin followed by lysis. The oxidation of hemoglobin followed by lysis. The ... | 197,102 | [
0.005830422,
0.1544458,
-0.05390036,
0.3373154,
0.04991873,
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0.2336981,
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0.08087394,
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0.2112018,
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0.3615201,
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0.1980845,
0.2629074,
0.4000667,
-0.05699277,
... |
Extraosseous accumulation of 99mTc phosphate tracers. Case report and review of reported causes. | A patient with a signet-ring-cell carcinoma of the stomach accumulating 99mTc methylene diphosphonate is described. Other conditions reported in the literature are reviewed. | 197,109 | [
-0.5181003,
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0.258771,
0.0955386,
0.1517173,
0.1005041,
0.0807265,
0.03095297,
0.... |
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