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Mezen Basin The is a sedimentary basin located in northwestern Russia. It list southeast of the White Sea and bounds the Timanide Orogen to the north and west. The basin is classified as a pericratonic and epicratonic foreland basin within the East European Craton. The contains the following pre-Vendian sediments: the ...
https://en.wikipedia.org/wiki?curid=48036401
Madras Naturalists' Society is a non-governmental organization that promotes appreciation, education and conservation of Nature. It was founded by bird watchers from the city of Madras (now Chennai), India) on 17 May 1978. G. K. Bhat was the organization's first President. The logo of the society is a Blackbuck The soc...
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NGC 6285 is an interacting spiral galaxy located in the constellation Draco. It is designated as S0-a in the galaxy morphological classification scheme and was discovered by the American astronomer Lewis A. Swift in 1886. is located at about 262 million light years away from earth. and NGC 6286 form a pair of interacti...
https://en.wikipedia.org/wiki?curid=48039287
NGC 6286 is an interacting spiral galaxy located in the constellation Draco. It is designated as Sb/P in the galaxy morphological classification scheme and was discovered by the American astronomer Lewis A. Swift on 13 August 1885. is located at about 252 million light years away from Earth. and NGC 6285 form a pair of...
https://en.wikipedia.org/wiki?curid=48040170
Maurits Lindström (10 May 1932 – 14 November 2009) was a Swedish geologist and paleontologist. Lindströms initial work was divided among two topics conodont paleontology and the structural geology of the Scandinavian Caledonides in Lappland. In 1970, he described the conodont families Cordylodontidae, Gondolellidae, Pr...
https://en.wikipedia.org/wiki?curid=48040831
NGC 6300 is a barred Seyfert spiral galaxy located in the constellation Ara. It is designated as SB(rs)b in the galaxy morphological classification scheme and was discovered by the Scottish astronomer James Dunlop on 30 June 1826. is located at about 51 million light years away from earth. It is suspected that a massiv...
https://en.wikipedia.org/wiki?curid=48043633
Henry Clay White (1848-1927) was an American chemist, notable for his contributions to agricultural science and higher education. He was also an early proponent of Darwin's theory of evolution. From 1872 to 1927, he was professor of chemistry at the University of Georgia. In 1893 he was elected as a member of the Royal...
https://en.wikipedia.org/wiki?curid=48046115
Proglacial river A proglacial river is a river that flows from the margin of a glacier. These rivers are strongly affected by the highly-seasonal water supply from the glacier and by the large supply of sediment that arrives at the glacier terminus. This high sediment supply often makes them steep and braided. Many mod...
https://en.wikipedia.org/wiki?curid=48047392
Microbial rhodopsin Microbial rhodopsins, also known as bacterial rhodopsins are retinal-binding proteins that provide light-dependent ion transport and sensory functions in halophilic This protein family includes light-driven proton pumps, ion pumps and ion channels, as well as light sensors. For example, the proteins...
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Microbial rhodopsin All animal rhodopsins arose (by gene duplication and divergence) late in the history of the large G-protein coupled receptor (GPCR) gene family, which itself arose after the divergence of plants, fungi, choanflagellates and sponges from the earliest animals. The retinal chromophore is found solely i...
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Microbial rhodopsin There are 9 subfamilies in the MR family: A phylogenetic analysis of microbial rhodopsins and a detailed analysis of potential examples of horizontal gene transfer have been published. Among the high resolution structures for members of the MR Family are the archaeal proteins, bacteriorhodopsin, sen...
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Microbial rhodopsin Homologues include putative fungal chaperone proteins, a retinal-containing rhodopsin from "Neurospora crassa", a H-pumping rhodopsin from "Leptosphaeria maculans", retinal-containing proton pumps isolated from marine bacteria, a green light-activated photoreceptor in cyanobacteria that does not pum...
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Microbial rhodopsin The mechanism involves: Six structural models describe the transformations of the retinal and its interaction with water 402, Asp85, and Asp212 in atomic detail, as well as the displacements of functional residues farther from the Schiff base. The changes provide rationales for how relaxation of the...
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Microbial rhodopsin reinhardtii" is closely related to the archaeal sensory rhodopsins. It has 712 aas with a signal peptide, followed by a short amphipathic region, and then a hydrophobic N-terminal domain with seven probable TMSs (residues 76-309) followed by a long hydrophilic C-terminal domain of about 400 residues...
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Microbial rhodopsin It may be a photoreceptor for dark adapted cells. A transient increase in hydration of transmembrane α-helices with a t(1/2) = 60 μs tallies with the onset of cation permeation. Aspartate 253 accepts the proton released by the Schiff base (t(1/2) = 10 μs), with the latter being reprotonated by aspar...
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Microbial rhodopsin , the native conformation of protein is stabilized in the trimeric protein-bacterioruberin complex. The generalized transport reaction for bacterio- and sensory rhodopsins is: That for halorhodopsin is:
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NGC 6328 is an intermediate spiral galaxy located in the constellation Ara. It is designated as SAB(s)ab in the galaxy morphological classification scheme and was discovered by the British astronomer John Herschel on 2 May 1835. is located at about 199 million light years away from earth.<ref name="NASA/IPAC"></ref>
https://en.wikipedia.org/wiki?curid=48060469
Heinrich Leonhards Skuja (1892–1972) was a botanist specialist of algae.
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Waulsortian mudmound A is a geographical feature formed in warm tropical waters in the Viséan geological age, now transposed to the temperate regions in Europe. It is a type of bioconstruction, rich in fossils. The rock comprises light grey, unbedded, micritic limestone, heavily jointed with calcite veining. There is s...
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Waulsortian mudmound There has been much debate on how the low micritic limestone hills in the Craven Basin were formed, one theory led to them being called reef knolls, knoll reefs, or bioherms but work in 1972 by Miller & Grayson identified them as mud mounds with the same fossil content as those near Waulsort. They ...
https://en.wikipedia.org/wiki?curid=48127400
Primary direction is a term in astronomy for the reference meridian used in a celestial coordinate system for that system's longitude.
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Javier Pérez-Ramírez (born 28 October 1974) is a Professor of Catalysis and Chemical Engineering at ETH Zurich. (JPR) studied Chemical Engineering at the University of Alicante, and later obtained his PhD cum laude at TU Delft (2002). He worked for Norsk Hydro and Yara International and returned to academia as a ICREA ...
https://en.wikipedia.org/wiki?curid=48135307
Javier Pérez-Ramírez He has developed novel catalysts for the gas-phase oxidation of hydrogen chloride (Deacon process) and has done major and groundbreaking contributions in the rational design of hierarchical zeolites. Pérez-Ramírez's work of nearly 400 articles and 17 patents has been recognized by several major pri...
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Specialty drugs in the United States Specialty drugs or specialty pharmaceuticals are a recent designation of pharmaceuticals that are classified as high-cost, high complexity and/or high touch. Specialty drugs are often biologics—"drugs derived from living cells" that are injectable or infused (although some are oral ...
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Specialty drugs in the United States In 2015 analysis by "The Wall Street Journal" suggested the large premium was due to the perceived value of rare disease treatments which usually are very expensive when compared to treatments for more common diseases. Medications must be either identified as high cost, high complex...
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Specialty drugs in the United States "[T]hose pharmaceuticals that usually require special handling, administration, unique inventory management, and a high level of patient monitoring and support to consumers with specific chronic conditions, acute events, or complex therapies, and provides comprehensive patient educa...
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Specialty drugs in the United States Gene-based and cellular biologics, for example, often are at the forefront of biomedical research, and may be used to treat a variety of medical conditions for which no other treatments are available." According to the U.S. Food and Drug Administration (FDA) biologics, or Some speci...
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Specialty drugs in the United States Specialty drugs may be taken "by relatively small patient populations presenting with complex medical conditions". "Specialty pharmacies have their roots in the 1970s, when they began delivering temperature-controlled drugs to treat cancer, HIV, infertility and hemophilia." Accordin...
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Specialty drugs in the United States According to a 2010 article in "Forbes", prior to 1983 drug companies largely ignored rare diseases and focused on drugs that affected millions of patients. The term "specialty drugs" was used as early as 1988 in a "New York Times" article about Eastman Kodak Company's acquisition o...
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Specialty drugs in the United States In 2003 the Medicare Prescription Drug, Improvement, and Modernization Act was enacted—the largest overhaul of Medicare in the public health program's 38-year history—included Medicare Part D an entitlement benefit for prescription drugs, through tax breaks and subsidies. In 2004 th...
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Specialty drugs in the United States By 2011 in the United States a growing number of Medicare Part D health insurance plans—which normally include generic, preferred, and non-preferred tiers with an accompanying rate of cost-sharing or co-payment—had added an "additional tier for high-cost drugs which is referred to a...
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Specialty drugs in the United States "In 2010, 48% of all new molecular entities, and 60% of all new specialty drug approvals, required a REMS program." Risk-reduction mechanisms can include the "use of specialized distribution partners", special pharmacy. In 2013 the FDA introduced the breakthrough therapy designation...
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Specialty drugs in the United States By 2014 it had grown to "$78 billion in sales". In Canada by 2013 "specialty drugs made up less than 1.3 percent of all Canadian prescriptions, but accounted for 24 percent of Canada's total spending on prescription drugs". When Randy Vogenberg of the Institute for Integrated Health...
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Specialty drugs in the United States High prices for specialty drugs are a problem for both patients and payers. Patients frequently have difficulty paying for these medications, which can lead to lack of access to treatment. Specialty drugs are now so expensive that they are leading to increases in insurance premiums....
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Specialty drugs in the United States " In 2013 AfPA director David Charles published an article on specialty drugs in which he agreed with the findings of the Congressional Budget Office that spending on prescription medications "saves costs in other areas of healthcare spending". He observed that specialty drugs are s...
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Specialty drugs in the United States 6% more on hepatitis C medications in 2014 than it did in 2013; this therapy class was not among the top 10 specialty classes in 2013. As the market demanded specialization in drug distribution and clinical management of complex therapies, specialized pharma (SP) evolved.„ By 2001 C...
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Specialty drugs in the United States McKesson Specialty Care Solutions, a division of McKesson Corporation, is "one of the largest distributors of specialty drugs, biologics and rheumatology drugs to community-based specialty practices". It is "a leader in the development, implementation and management of FDA-mandated ...
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Specialty drugs in the United States Biologics are isolated from a variety of natural sources—human, animal, or microorganism—and may be produced by biotechnology methods and other cutting-edge technologies". Due to the complexity, risk of adverse events and allergic reactions associated with biologics, management is v...
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Specialty drugs in the United States For physician-administered biologics, cost-containment is often handled by volume purchasing of biologic drugs for discounted pricing, formularies, step therapy to attempt other treatment before beginning biologics and administrative fees by insurers to keep physicians from artifici...
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Specialty drugs in the United States Comparative effectiveness would examine all aspects of the use of biologics, from outcomes such as clinical benefits and potential harms, to efficiency of administration, public health benefits and patient productivity after treatment. This is a new direction in managing the high co...
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Specialty drugs in the United States Biologics or biological products for human use are regulated by the Center for Biologics Evaluation and Research (CBER), overseen by the Office of Medical Products and Tobacco, within the U.S. Food and Drug Administration which includes the Public Health Service Act and the Federal ...
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Specialty drugs in the United States " Alexion Pharmaceuticals was one of the pioneers in the use of a business model of developing drugs to combat rare diseases. "Knowing the value of specialty drugs as well as its own stock is Alexion's business." Since other big pharmaceutical companies had tended to ignore these ma...
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Specialty drugs in the United States Specialty medications may be covered under either the medical or pharmacy benefit." According to an article published in 2014 in the journal "Pharmacoeconomics", "[s]pecialty pharmacies combine medication dispensing with clinical disease management. Their services have been used to ...
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Specialty drugs in the United States Health plans consider "high cost" (on average a minimum monthly costs of $US1,200) to be is a determining factor in identifying a specialty drug. Tom Westrich, of St. Louis, Missouri-based Centric Health Resources, a specialty pharmacy, described how their specialty drugs treat ultr...
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Specialty drugs in the United States Self-injected medications may be either. "Many biologics, such as chemotherapy drugs, are administered in a doctor's office and require extensive monitoring, further driving up costs." Chemotherapy is usually delivered intravenously, although a number of agents can be administered o...
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Specialty drugs in the United States " While CVS, Accredo, and Walgreens led the Specialty Pharmacies (SP) market in revenue in 2014, there are constant changes through mergers and acquisitions in terms of SPs and specialty distributors (SDs). The SP/SD network faces common strengths such as "in-depth clinical manageme...
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Specialty drugs in the United States " Basta described how Hubs have been around since about 2002 "starting out as "reimbursement hubs"", usually provided as a service by manufacturers to help patients and providers navigate the process of obtaining permission to use, and reimbursement for, expensive specialty therapie...
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Specialty drugs in the United States Bailey, a mechanical engineer by training who became interim president of Questcor Pharmaceuticals, Inc. (Questcor) in May 2007, initiated a new pricing model for Acthar in August 2007 when it was classified by FDA as an orphan drug and a specialty drug to treat infantile spasms. Qu...
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Specialty drugs in the United States Sovaldi is on the World Health Organization's most important medications needed in a basic health system and the steep price is highly controversial. In 2014 the U.S. spent 742.6% more on hepatitis C medications than it did in 2013. In September 2015, Martin Shkreli was criticized b...
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Specialty drugs in the United States Express Scripts was "evaluating other 'captive pharmacies' that it said are mostly distributing Horizon drugs". In 2015 specialty pharmacies like "Philidor drew attention for the lengths they went to fill prescriptions with brand-name drugs and then secure insurance reimbursement. A...
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Alla Masevich Alla Genrikhovna Masevich (October 9, 1918 — May 6, 2008) was a Soviet astronomer. She graduated from Moscow State Pedagogical University. She served as deputy chairman of the Astronomical Council of the Academy of Sciences of the USSR in 1952, and worked closely with Victor Ambartsumian. She became a pro...
https://en.wikipedia.org/wiki?curid=48201018
List of the physiographic regions of the world The landforms of the Earth are generally divided into physiographic divisions, consisting of physiographic provinces, which in turn consist of physiographic sections, though some others use different terminology, such as realms, regions and sub-regions. Some areas have fur...
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Collage (geology) In geology a collage is a tectonostratigraphic unit characterized by its heterogeneity in terms of its lithology, rock ages, or both. The term is usually applied to Precambrian tectonostratigraphic units. Collages form by plate tectonic processes like accretion and continental collision.
https://en.wikipedia.org/wiki?curid=48215783
NGC 120 is a lenticular galaxy of type SB0? pec? with an apparent magnitude of 13.4 located in the constellation Cetus. It was descovered on 27 September 1880 by Wilhelm Tempel.
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William Andrew Clark Dr FRSE (1911-1983) was a Scottish botanist known for collections largely in the Outer Hebrides. He was an expert on spermatophytes and the flora of north-east England. He was born in Girvan in Ayrshire the son of Thomas Clark. He attended Alva Academy 1916-1923 and then Harris Academy in Dundee 19...
https://en.wikipedia.org/wiki?curid=48246659
Chromogen The term chromogen is applied in chemistry to a colourless (or weakly coloured) chemical compound that can be converted by chemical reaction into a compound which can be described as "coloured". There is no universally agreed definition of the term. Various dictionaries give the following definitions: In bioc...
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Phase stretch transform (PST) is a computational approach to signal and image processing. One of its utilities is for feature detection and classification. PST is related to time stretch dispersive Fourier transform. It transforms the image by emulating propagation through a diffractive medium with engineered 3D disper...
https://en.wikipedia.org/wiki?curid=48249441
Phase stretch transform Photonic time stretch technique can be understood by considering the propagation of an optical pulse through a dispersive fiber. By disregarding the loss and non-linearity in fiber, the non-linear Schrödinger equation governing the optical pulse propagation in fiber upon integration reduces to: ...
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Phase stretch transform The function formula_21 is the warped phase kernel and the function formula_22 is a localization kernel implemented in frequency domain. PST operator is defined as the phase of the Warped Stretch Transform output as follows formula_23 (7) where formula_24is the angle operator. PST has been used ...
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Phase stretch transform However, it is provided for research purposes only, and a license must be obtained for any commercial applications. The software is protected under a US patent.
https://en.wikipedia.org/wiki?curid=48249441
Pursuit predation is a form of predation in which predators give chase to fleeing prey. The chase can be initiated either by the predator or by the prey, should the prey be alerted to a predator's presence and attempt to flee before the predator gives chase. The chase ends when either the predator captures and consumes...
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Pursuit predation Other species choose to hunt alone. These two behaviors are typically due to differences in hunting success, where some groups are very successful in groups and others are more successful alone. Pursuit predators may also choose to either exhaust their metabolic resources rapidly or pace themselves du...
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Pursuit predation Group pursuit is usually seen in species of relatively high sociality; in vertebrates, individuals often seem to have defined roles in pursuit. African wild dog ("Lycaon pictus") packs have been known to split into several smaller groups while in pursuit; one group initiates the chase, while the other...
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Pursuit predation Many observations of group pursuers note an optimal hunting size in which certain currencies (mass of prey killed or number of prey killed) are maximized with respect to costs (kilometers covered or injuries sustained). Groups size is often dependent on aspects of the environment: number of prey, prey...
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Pursuit predation As in vertebrates, there are many species of invertebrates which actively pursue prey in groups and exhibit task specialization, but while the vertebrates change their behavior based on their role in hunting, invertebrate task delegation is usually based on actual morphological differences. The vast m...
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Pursuit predation The giant hornets group together and as a team can decimate an entire honeybee colony, especially those of non-native European honeybees. Alone, the hornets are subject to attack by the smaller bees, who swarm the hornet and vibrate their abdomens to generate heat, collectively cooking the hornet unti...
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Pursuit predation When flies, prey for redstarts, are alerted of the presence of predators, they respond by fleeing. Redstarts take advantage of this anti-predator response by spreading and orienting their easily noticeable wings and tails, alerting the flies, but only when they are in a position where the flies' escap...
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Pursuit predation Dragonflies high success rate for prey capture may also be due to their interception foraging method. Unlike classical pursuit, in which the predator aims for the current position of their prey, dragonflies predict the prey's direction of motion, as in parallel navigation. Perching dragonflies (Libell...
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Pursuit predation As selective pressure on prey is higher than on predators adaptation usually occurs in prey long before the reciprocal adaptations in predators. Evidence in the fossil record supports this, with no evidence of modern pursuit predators until the late Tertiary period. Certain adaptations, like long limb...
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Pursuit predation In addition to serving as a countermeasure to prey adaptation, pursuit predation has evolved in some species as an alternative, facultative mechanism for foraging. For example, polar bears typically act as specialized predators of seal pups and operate in a manner closely predicted by the optimal fora...
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Pursuit predation Models of spatial patterns and synchrony of predator-prey relationships can be used as support for the evolution of pursuit predation as one mechanism to preserve these population mechanics. By pursuing prey over long distances, predators actually improve longterm survival of both their own population...
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Pursuit predation Alarm displays are used more often when prey believe predators are more prone to change their decision to pursue. For instance, cheetahs, common predators of Thomson's gazelles, are less likely to change their choice to pursue. As such, gazelles stott less when cheetahs are present than when other pre...
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Pursuit predation This is especially true in open habitats, such as grasslands or open ocean ecosystems, where view of the prey group is unobstructed, in contrast to a forest or reef. Prey species in these open environments tend to be especially gregarious, with notable examples being starlings and sardines. When indiv...
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Roger J. Thomas was a solar physicist who worked at NASA for many years. He was an internationally recognized expert on the design of extreme ultraviolet spectrographs, and received the prestigious NASA Exceptional Service Medal in 2009.
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List of bacterial disulfide oxidoreductases Bacterial "thiol disulfide oxidoreductases (TDOR)" are bacterial enzymes which, along with unfolded proteins, are pumped out of a bacterial cell that allow for adhesion and biofilm development, and generally disease development.
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Yttrogummite is a yttrium-bearing variety of gummite mineral. It is a rare earth mineral containing relatively large amounts of the yttrium earths. It is an alteration product of yttrian uraninite. It was first described by Adolf Erik Nordenskiöld, who discovered it in Arendal, Norway in 1870s.
https://en.wikipedia.org/wiki?curid=48374150
Mahendra Verma Mahendra Kumar Verma (born 27 May 1966) is an Indian physicist and professor at the Indian Institute of Technology Kanpur who works on fluid dynamics, turbulence, and nonlinear dynamics. Verma earned his bachelor's degree in computer science from the Indian Institute of Technology Madras in 1988, and a P...
https://en.wikipedia.org/wiki?curid=48382174
Irina Veretennicoff is a physicist, honorary professor of the Vrije Universiteit Brussel. Veretennicoff graduated in Physics from the Vrije Universiteit Brussel (VUB) in 1973 with a doctorate under the guidance of Radu Balescu of Université libre de Bruxelles (ULB). has been an honorary member of the Class of Natural S...
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Structure function The structure function (also known as the proton structure function), like the fragmentation function, is a probability density function. It is somewhat analogous to the structure factor in solid-state physics, and the form factor (quantum field theory). The nucleon (proton and neutron) electromagnet...
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Shobhana Narasimhan is a Professor of Theoretical Sciences at the Jawaharlal Nehru Centre for Advanced Scientific Research in Bangalore, India. Her main area of interest is computational nanoscience. Her research examines how the lowering of dimensionality and reduction of size affect material properties. She is a Fell...
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Shobhana Narasimhan and at the East African Institute for Fundamental Research in Kigali, Rwanda. Narasimhan became a Fellow of the National Academy of Sciences, India in 2011. She also received the Stree Shakti Samman Science Award in 2010 and the Kalpana Chawla Woman Scientist Award of the Government of Karnataka in ...
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M. S. Ramakumar Mallasamudram Subramanyam Ramakumar was an Indian mechanical engineer, outstanding scientist and roboticist, known for developing robotic and automation technologies for Indian nuclear and defence purposes. He was the director of Nuclear Fuels, Automation and Manufacturing Group of the Bhabha Atomic Res...
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Biconcave disc A biconcave disc — also referred to as a discocyte — is a geometric shape resembling an oblate spheroid with two concavities on the top and on the bottom. It is meta-stable, and involves the continuous adjustment of the asymmetric transbilayer lipid distribution, which is correlated with ATP depletion. A...
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Maitree Bhattacharyya is a Professor and the Director of Jagadis Bose National Science Talent Search (JBNSTS), Kolkata, which works for the propagation of scientific temperament among the young students of the country. She graduated from Presidency College with Honours in Physics and obtained M.Sc degree from the Scien...
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Timeline of plastic development This is a timeline of the development of plastics, comprising key discoveries and developments in the production of plastics.
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Jo-Anne H. Young (née van Burik) is an American physician, scientist, and Editor-in-Chief of "Clinical Microbiology Reviews", published by the American Society for Microbiology. Her expertise is in the areas of transplantation, infectious diseases, infections of the immune compromised host, and clinical mycology and vi...
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Sofia Romanskaya (1886–1969) was a Soviet astronomer known as one the first Russian women to have a significant role in the field. Sofia (also spelled Sofya) Vasilievna Voroshilova-Romanskaya was born in St. Petersburg. She graduated from the Bestuzhev Courses, a prominent women's educational institution of the Russian...
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Mandar Madhukar Deshmukh (born 20 October 1974) is an Indian physicist specialising in nanoscale and mesoscopic physics and affiliated to Tata Institute of Fundamental Research, Mumbai. He was awarded the Shanti Swarup Bhatnagar Prize for Science and Technology in 2015, the highest science award in India, in the physic...
https://en.wikipedia.org/wiki?curid=48465317
Teodor Bordeianu (February 16 1902 – March 19 1969) was a Romanian agronomist and pomologist who was a member of the Romanian Academy. He was born in the village of Marșenița, which is today in Ukraine, and died in Bucharest, Romania.
https://en.wikipedia.org/wiki?curid=48477239
Encapsulin nanocompartment Encapsulin nanocompartments, or encapsulin protein cages, are spherical bacterial organelle-like compartments roughly 25-30 nm in diameter that are involved in various aspects of metabolism, in particular protecting bacteria from oxidative stress. Encapsulin nanocompartments are structurally ...
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993–994 carbon-14 spike The was a rapid increase in carbon-14 content from tree rings, and followed the 774–775 carbon-14 spike. This event is also confirmed by a sharp increase of beryllium-10 and hence considered as solar-origin. It may have come from a massive solar storm as a series of auroral observations are know...
https://en.wikipedia.org/wiki?curid=48508353
Ligia Gargallo is a Chilean chemist and university professor of the Pontifical Catholic University of Chile. She works at the University of Tarapacá (Arica) and at the Pontifical Catholic University of Chile, in Santiago. She received a bachelor's degree in chemical pharmaceutical at the University of Chile in 1959, de...
https://en.wikipedia.org/wiki?curid=48514474
Computational anatomy is an interdisciplinary field of biology focused on quantitative investigation and modelling of anatomical shapes variability. It involves the development and application of mathematical, statistical and data-analytical methods for modelling and simulation of biological structures. The field is br...
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Computational anatomy The flows between coordinates in computational anatomy are constrained to be geodesic flows satisfying the principle of least action for the Kinetic energy of the flow. The kinetic energy is defined through a Sobolev smoothness norm with strictly more than two generalized, square-integrable deriva...
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Computational anatomy This connects it to D'Arcy Wentworth Thompson's developments On Growth and Form which has led to scientific explanations of morphogenesis, the process by which patterns are formed in Biology. Albrecht Durer's Four Books on Human Proportion were arguably the earliest works on computational anatomy....
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Computational anatomy The diffeomorphometry metric of measures how far two diffeomorphic changes of coordinates are from each other, which in turn induces a metric on the shapes and images indexed to them. The models of metric pattern theory, in particular group action on the orbit of shapes and forms is a central tool...
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Computational anatomy The first formalization of computational anatomy as an orbit of exemplar templates under diffeomorphism group action was in the original lecture given by Grenander and Miller with that title in May 1997 at the 50th Anniversary of the Division of Applied Mathematics at Brown University, and subsequ...
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Computational anatomy The Lagrangian and Hamiltonian formulations of the equations of motion of computational anatomy took off post 1997 with several pivotal meetings including the 1997 Luminy meeting organized by the Azencott school at Ecole-Normale Cachan on the "Mathematics of Shape Recognition" and the 1998 Trimest...
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Computational anatomy Subsequently, connections were made between Computational anatomy's Euler-Lagrange equations for momentum densities for the right-invariant metric satisfying Sobolev smoothness to Vladimir Arnold's characterization of the Euler equation for incompressible flows as describing geodesics in the group...
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Computational anatomy Since the late 1990s, computational anatomy has become an important part of developing emerging technologies for the field of medical imaging. Digital atlases are a fundamental part of modern Medical-school education and in neuroimaging research at the morphome scale. Atlas based methods and virtu...
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