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NGC 407 is a lenticular galaxy located in the constellation Pisces. It was discovered on September 12, 1784 by William Herschel. It was described by Dreyer as "very faint, very small, southwestern of 2.", the other being NGC 410. | https://en.wikipedia.org/wiki?curid=53091909 |
NGC 409 is an elliptical galaxy located in the constellation Sculptor. It was discovered on November 29, 1837 by John Herschel. It was described by Dreyer as "extremely faint, small, round, very small (faint) star near." | https://en.wikipedia.org/wiki?curid=53091972 |
NGC 410 is an elliptical galaxy located in the constellation Pisces. It was discovered on September 12, 1784 by William Herschel. It was described by Dreyer as "pretty bright, pretty large, northeastern of 2.", the other being NGC 407. | https://en.wikipedia.org/wiki?curid=53094397 |
Carl August Lundström (1844 -1914) was a Finnish entomologist who specialised in Diptera especially Nematocera. He was a Professor in Helsinki. His insect collection is held by the Finnish Museum of Natural History. partial list | https://en.wikipedia.org/wiki?curid=53118394 |
Edward M. Stricker is an American neuroscientist, currently a University Professor at the University of Pittsburgh and formerly Dean at its Honors College. Professor Stricker (born in New York, NY) earned a bachelor's degree from the University of Chicago in 1960, a master's degree in chemistry from that same instituti... | https://en.wikipedia.org/wiki?curid=53122933 |
Edward M. Stricker His teaching ranged from introductory courses to graduate courses in neuroscience, as well as interdisciplinary honors courses. In recognition of his teaching, the University of Pittsburgh has awarded him the 2001 Tina & David Bellet Teaching Excellence Award and 1992 Chancellor's Distinguished Teach... | https://en.wikipedia.org/wiki?curid=53122933 |
Christian Stenhammar (1783-1866) was a Swedish naturalist interested in lichens and an entomologist who specialised in Diptera.His collection is held by Uppsala University.He was a clergyman. Genera named to honor are "Stenhammara" and "Stenhammarella" Eckhard K. Groll | https://en.wikipedia.org/wiki?curid=53127594 |
NGC 413 is a spiral galaxy of type SB(r)c located in the constellation Cetus. It was discovered in 1886 by Francis Leavenworth. It was described by Dreyer as "extremely faint, pretty small, very little extended." | https://en.wikipedia.org/wiki?curid=53134676 |
NGC 414 is a pair of lenticular galaxies (PGC 4254 and PGC 93079) of types S0 and E/S0, respectively, located in the constellation Pisces. It was discovered on October 22, 1867 by Herman Schultz. It was described by Dreyer as "very faint, small, irregularly round, much brighter middle, II 220 to the northwest.", with I... | https://en.wikipedia.org/wiki?curid=53144610 |
NGC 415 is a spiral galaxy of type SB(rb)b located in the constellation Sculptor. It was discovered on September 1, 1834 by John Herschel. It was described by Dreyer as "very faint, small, round, gradually a little brighter middle." | https://en.wikipedia.org/wiki?curid=53144687 |
Benjamin August Gimmerthal (1779, Zittau- 1848, Riga (then Russian Empire)) was a German entomologist who specialised in Diptera. His collection of Chloropidae is held by the Museum of Systematic Zoology, University of Latvia, Riga. The remaining Diptera and other insects by the Natural History Museum of Latvia (Homepa... | https://en.wikipedia.org/wiki?curid=53155094 |
List of scattering experiments This is a list of scattering experiments. | https://en.wikipedia.org/wiki?curid=53155398 |
Joseph Jean Baptiste Géhin (1816, Remiremont - 1889, Remiremont) was a French naturalist and entomologist who specialised in Coleoptera. He also studied Diptera. He was an apothecary in Metz. His collections of Carabidae were purchased by René Oberthür and are now held by Muséum national d'histoire naturelle in Paris.G... | https://en.wikipedia.org/wiki?curid=53159112 |
Karl Escherich Karl Leopold Escherich (18 September 1871 – 22 November 1951) was a German entomologist and professor of zoology. Known as a pioneer of applied entomology and expert in termites, he was rector of the University of Munich from 1933 to 1936. Escherich was born in Schwandorf, Bavaria, to parents Hermann N. ... | https://en.wikipedia.org/wiki?curid=53159121 |
Karl Escherich To commemorate its founder, the German Society for Applied Entomology awards the Escherich Medal for outstanding achievements in the field of entomology. | https://en.wikipedia.org/wiki?curid=53159121 |
NGC 417 is a lenticular galaxy of type SAB0 located in the constellation Cetus. It was discovered in 1886 by Francis Leavenworth. It was described by Dreyer as "extremely faint, extremely small, round." | https://en.wikipedia.org/wiki?curid=53163163 |
NGC 418 is a barred spiral galaxy of type SB(s)c located in the constellation Sculptor. It was discovered on September 28, 1834 by John Herschel. It was described by Dreyer as "faint, pretty large, round, very gradually a little brighter middle, western of 2.", the other being NGC 423. | https://en.wikipedia.org/wiki?curid=53163190 |
Siamese buffalo The Krabue buffalo (Thai: กระบือ; ("krabue") being the Thai word for "water buffalo") also known as the Siamese buffalo, Thai water buffalo or Thai swamp buffalo is a large breed of water buffalo indigenous to Thailand. | https://en.wikipedia.org/wiki?curid=53166752 |
Johann Jacob Bremi-Wolf (25 May 1791, Dübendorf – 27 February 1857, Zürich) was a Swiss entomologist and "Kunsthandwerker" (art turner) in Zürich. He was deaf due to illness at the age of 11. His entomological herbarium is held by the Museum Wiesbaden. Other parts of his insect collection, especially Diptera are held b... | https://en.wikipedia.org/wiki?curid=53170285 |
NGC 7640 is a barred spiral galaxy in the constellation of Andromeda. There is evidence that this galaxy has experienced an interaction with another galaxy in the (astronomically) recent past. It is not immediately obvious this is a spiral galaxy from the photograph because it is edge on. | https://en.wikipedia.org/wiki?curid=53177263 |
Color Genomics Color is a population health technology company which provides genetic tests and analysis directly to patients as well as through employers. The product focuses on genes that indicate risk for heart disease, cancer, and that affect medication response. The company was co-founded in 2015 by Elad Gil, Nish... | https://en.wikipedia.org/wiki?curid=53178099 |
Color Genomics Testing used to cost $4,000, insurance had burdensome requirements for coverage, and even if insurance would cover the costs, testing often required multiple in-person visits, preventing people from learning information that could save their lives. Color’s product is a genetic test that costs $249, genet... | https://en.wikipedia.org/wiki?curid=53178099 |
Color Genomics Color's CLIA-certified and CAP-approved lab analyzes for variants in the breast cancer genes "BRCA1" and "BRCA2", as well as 28 other genes associated with breast, prostate, colon, uterine, stomach, melanoma, pancreatic, and ovarian cancers. The test also identifies variants in 30 genes related to heredi... | https://en.wikipedia.org/wiki?curid=53178099 |
Color Genomics As the awardee, Color will customize software and tools to integrate data from all the genome centers, standardize reporting across the program, and ensure all results are returned in a unified way. This is a first year $4.6 million grant as part of a multi-year $25 million project. In collaboration with... | https://en.wikipedia.org/wiki?curid=53178099 |
Color Genomics Laura Esserman at University of California and Sanford Health, Color is providing genetic testing for WISDOM, a 100,000-woman study that is comparing annual screenings with personalized, risk-based breast cancer screenings. As part of the GENtleMEN Study, Color is working with Dr. Heather Cheng at the Fr... | https://en.wikipedia.org/wiki?curid=53178099 |
Edouard Perris full name Jean-Pierre Omer Anne (1808, Pau- Mont-de-Marsan 1878) was a French explorer and entomologist who specialised in Coleoptera and to a lesser extent Diptera and other orders. He was Chef de division à la préfecture des Landes. Perris was a Member of Société Entomologique de France. His collection... | https://en.wikipedia.org/wiki?curid=53178605 |
Patrick Douglas Baird (1912 – 1 January 1984) was a Scottish glaciologist who worked in the Canadian Arctic. He was born the fourth son of Brigadier-General E.W.D. Baird of Caithness, Scotland and was educated at Edinburgh Academy and Corpus Christi College, Cambridge, graduating in Geology. After working for some year... | https://en.wikipedia.org/wiki?curid=53208278 |
Patrick Douglas Baird During his time there he organised and led two major expeditions to Baffin Island, one in 1950 to the Barnes Ice Cap region and one in 1953 to the Pangnirtung Pass and Penny Highlands area, which carried out the first glaciological investigations in the Canadian Arctic. Baird became an acknowledge... | https://en.wikipedia.org/wiki?curid=53208278 |
NGC 6801 is a spiral galaxy in the constellation of Cygnus. It was discovered by Lewis A. Swift on August 5, 1886. In May 2011 a Type Ia supernova, 2011df, was detected in NGC 6801. 2015af, a Type II supernova was discovered in August 2015. | https://en.wikipedia.org/wiki?curid=53248722 |
NGC 4707 is an irregular galaxy in the constellation of Canes Venatici. It was discovered by John Herschel on 5 June 1834, and was described by John Louis Emil Dreyer, the compiler of the New General Catalogue, as a "small, stellar" galaxy. has a morphological type of Sm or Im, meaning that it is mostly irregular or ha... | https://en.wikipedia.org/wiki?curid=53250541 |
Leaf flushing is the production of a flush of new leaves typically produced simultaneously on all branches of a bare plant or tree. succeeds leaf fall, and is delayed by winter in the temperate zone or by extreme dryness in the tropics but leaf fall and leaf flushing in tropical deciduous forests can overlap, with new ... | https://en.wikipedia.org/wiki?curid=53258862 |
NGC 1222 is an early-type lenticular galaxy located in the constellation of Eridanus. The galaxy was discovered on 5 December 1883 by the French astronomer Édouard Stephan. John Louis Emil Dreyer, the compiler of the New General Catalogue, described it as a "pretty faint, small, round nebula" and noted the presence of ... | https://en.wikipedia.org/wiki?curid=53261402 |
NGC 5308 is an edge-on lenticular galaxy in the constellation of Ursa Major. It was discovered on 19 March 1790 by William Herschel. It was described by John Louis Emil Dreyer as "bright, pretty large" when he compiled the New General Catalogue. A small, irregular galaxy near has been given the designation LEDA 2802348... | https://en.wikipedia.org/wiki?curid=53264021 |
Comet (experiment) COMET (COherent Muon to Electron Transition) is currently a funded experiment in J-PARC, Tokai, Japan. In contrast to the usual muon decay to an electron and neutrino, COMET seeks to look for neutrinoless muon to electron conversion, where the electron flies away with an energy of 104.8 MeV. Muon to ... | https://en.wikipedia.org/wiki?curid=53281588 |
Oscar Ringdahl (1885–1966) was a Swedish entomologist who specialised in Diptera and Trichoptera. Ringdahl described many new species from Sweden and Lappland. Parts of his personal collection are in the Swedish Museum of Natural History and Lund University Zoology Museum (Lunds Universitet Zoologiska museet), Lund. Pa... | https://en.wikipedia.org/wiki?curid=53289070 |
Eric Hessels Eric A. Hessels is a Canadian physicist, currently a Canada Research Chair and Distinguished Research Professor at York University in Toronto, Ontario. In September 2019, Hessels et al. measured the Lamb shift for hydrogen to measure the radius of a proton and demonstrated that it is consistent with the va... | https://en.wikipedia.org/wiki?curid=53292802 |
NGC 2357 is a spiral galaxy located in the constellation of Gemini. It was discovered by Édouard Stephan on 6 February 1885. SN 2010bj, a Type II-P supernova, was detected in February 2010, and SN 2015I, a Type Ia supernova was detected in May 2015. | https://en.wikipedia.org/wiki?curid=53293034 |
NGC 3464 is a barred spiral galaxy in the constellation of Hydra, discovered 14 January 1886 by Ormond Stone. Two supernovae were observed in in 2002. SN 2002J, a Type Ic supernova, was detected 21 January, and SN 2002hy, a Type Ib supernova, was detected 12 November. A Type Ia supernova, SN 2015H, was first observed 1... | https://en.wikipedia.org/wiki?curid=53294175 |
NGC 420 is a lenticular galaxy of type S0 located in the constellation Pisces. It was discovered on September 12, 1784 by William Herschel. It was described by Dreyer as "faint, pretty small, round, brighter middle." | https://en.wikipedia.org/wiki?curid=53294475 |
Biomedical research in the United States The US carries out 46% of global research and development (R&D) in the life sciences, making it the world leader in medical research. Life sciences accounted for 51% of federal research expenditure in 2011. The National Institutes of Health (NIH) are considered the government's ... | https://en.wikipedia.org/wiki?curid=53296445 |
Biomedical research in the United States The 21st Century Cures Act was signed into law on 13 December 2016, a year after the release of the UNESCO Science Report. The report had predicted that, ‘were the bill to pass into law, it would alter the way in which clinical trials are conducted by allowing new and adaptive t... | https://en.wikipedia.org/wiki?curid=53296445 |
Biomedical research in the United States The industrial partners are Abbvie (US), Biogen (US), Bristol-Myers Squibb (US), GlaxoSmithKline (UK), Johnson & Johnson (US), Lilly (US), Merck (US), Pfizer (US), Sanofi (France) and Takeda (Japan). Laboratories share samples, such as blood or brain tissue from deceased patient... | https://en.wikipedia.org/wiki?curid=53296445 |
Biomedical research in the United States Defined as delivering the right treatment to the right patient at the right time, precision medicine tailors treatments to patients based on their unique physiology, biochemistry and genetics. In his 2016 budget request, the president asked for US$215 million to be shared by the... | https://en.wikipedia.org/wiki?curid=53296445 |
Biomedical research in the United States Google was included for the first time in 2013 and Amazon in 2014, which is why the online store does not figure in the Top 50 for 2014. Global top 50 companies by R&D volume and intensity, 2014 <nowiki>*</nowiki> R&D intensity is defined as R&D expenditure divided by net sales.... | https://en.wikipedia.org/wiki?curid=53296445 |
Biomedical research in the United States Total investment in venture capital amounted to US$48.3 billion in 2014, for 4 356 deals. This represented ‘an increase of 61% in dollars and a 4% increase in deals over the prior year,’ reported the National Venture Capital Association. The Organisation for Economic Cooperation... | https://en.wikipedia.org/wiki?curid=53296445 |
Biomedical research in the United States About 31% of this spending went on specialty drug therapies to treat inflammatory conditions, multiple sclerosis, oncology, hepatitis C and HIV, etc., and 6.4% on traditional therapies to treat diabetes, high cholesterol, pain, high blood pressure and heart disease, asthma, depr... | https://en.wikipedia.org/wiki?curid=53296445 |
Biomedical research in the United States One inspiration for the act was that the patents for many biologic drugs will expire in the next decade. Although the act was passed in 2010, the first biosimilar was only approved in the US by the FDA in 2015: Zarxio, made by Sandoz. Zarxio is a biosimilar of the cancer drug Ne... | https://en.wikipedia.org/wiki?curid=53296445 |
Biomedical research in the United States The extent to which clinical trials are required will largely determine the cost of development. Orphan diseases affect fewer than 200 000 Americans each year. Since the Orphan Drug Act of 1983, over 400 drugs and biologic products for rare diseases have been designated by the F... | https://en.wikipedia.org/wiki?curid=53296445 |
Biomedical research in the United States Until 2010, the United States of America was a net exporter of pharmaceuticals. Since 2011, it has become a net importer of these goods. The United States has lost its world leadership for high-tech goods. Even computing and communications equipment is now assembled in China and... | https://en.wikipedia.org/wiki?curid=53296445 |
NGC 1741 is a distant pair of interacting galaxies (NGC 1741A and NGC 1741B) in the Eridanus constellation. It was discovered on 6 January 1878 by French astronomer Édouard Stephan. As a result of the collision, the galaxies are in a rapid starbust phase. The galaxies are classed as Wolf–Rayet galaxies due to their hig... | https://en.wikipedia.org/wiki?curid=53303491 |
FlowFET A flowFET is a microfluidic component which allows the rate of flow of liquid in a microfluidic channel to be modulated by the electrical potential applied to it. In this way, it behaves as a microfluidic analogue to the field effect transistor, except that in the flowFET the flow of liquid takes the place of t... | https://en.wikipedia.org/wiki?curid=53307338 |
FlowFET The speed is related to the strength of the electric field formula_2, the magnitude of the zeta potential formula_3, the permittivity formula_4 and the viscosity formula_5 of the fluid: formula_6 In a FlowFET, the zeta potential between the channel walls and the fluid can be altered by applying an electrical fi... | https://en.wikipedia.org/wiki?curid=53307338 |
FlowFET While the controlling voltage need only be on the order of 50V, the EOF-producing voltage along the channel axis is larger, on the order of 300V. It is noticed experimentally that electrolysis may occur at the electrode contacts. This water electrolysis can alter the pH in the channel and adversely affect biolo... | https://en.wikipedia.org/wiki?curid=53307338 |
FlowFET Fewer moving parts allows less opportunity for mechanical breakdown of a microfluidic device. This may be increasingly relevant as large future iterations of large microelectronic fluidic (MEF) arrays continue to increase in size and complexity. The use of bi-directional electronically-controlled flow has inter... | https://en.wikipedia.org/wiki?curid=53307338 |
NGC 5264 NGC 5264, also known as DDO 242, is an irregular galaxy in the constellation Hydra. It is part of the M83 subgroup of the Centaurus A/M83 Group, located some 15 million light years (4.5 megaparsecs) away. The galaxy was discovered on 30 March 1835 by John Herschel, and it was described as "very faint, pretty l... | https://en.wikipedia.org/wiki?curid=53311012 |
Thomas Glanville Taylor (22 November 1804 – 4 May 1848) was an English astronomer who worked extensively at the Madras Observatory and produced the Madras Catalogue of Stars from around 1831 to 1839. He was the son of Thomas Taylor, assistant at the Royal Greenwich Observatory, and his wife Susannah née Glanville, born... | https://en.wikipedia.org/wiki?curid=53345171 |
Thomas Glanville Taylor Taylor began the publication of the "Madras General Catalogue of Stars" which was praised by Sir George Airy. His catalogues were of importance in navigation and in the Trigonometrical Survey for determining longitude as well as latitude. Taylor married Eliza Baratty, daughter of Colonel Eley, o... | https://en.wikipedia.org/wiki?curid=53345171 |
Lilabati Bhattacharjee (née Ray) was a mineralogist, crystallographer and a physicist. She studied with scientist Satyendra Nath Bose and completed her MSc in Physics from the Rajabazar Science College campus of University of Calcutta in 1951. Mrs Bhattacharjee specialised in the fields of structural crystallography, o... | https://en.wikipedia.org/wiki?curid=53349635 |
CRISPR-Display (CRISP-Disp) is a modification of the CRISPR/Cas9 (Clustered regularly interspaced short palindromic repeats) system for genome editing. The CRISPR/Cas9 system uses a short guide RNA (sgRNA) sequence to direct a "Streptococcus pyogenes" Cas9 nuclease, acting as a programmable DNA binding protein, to clea... | https://en.wikipedia.org/wiki?curid=53354629 |
CRISPR-Display In January 2013, the Feng Zhang lab at the Broad Institute at MIT published another method in Science, having further optimized the sgRNA structure and expression for use in mammalian cells. By the beginning of 2014, almost 2500 studies mentioning CRISPR in their title has been published. Non-coding RNAs... | https://en.wikipedia.org/wiki?curid=53354629 |
CRISPR-Display e. nuclease deficient, Cas9 mutant (dCas9), and altering the RNA used for targeting Cas9 to a genomic location. Since sgRNAs are usually expressed by RNA polymerase III, which limits the length of the RNA domain that can be inserted, incorporates RNA polymerase II to permit expression of longer transcrip... | https://en.wikipedia.org/wiki?curid=53354629 |
CRISPR-Display Two variations of such a transcription activator assay was performed; directly with a dCas9 fused to a transcriptional activator/repressor (VP64, a factor known to enhance gene expression) (Direct activation) or indirectly where the transcriptional activator is fused to an RNA binding protein module on t... | https://en.wikipedia.org/wiki?curid=53354629 |
CRISPR-Display Reporter assays and RIP-Seq confirmed that sequence does not govern complex efficacy. The utility of CRISP-Disp was explored with an array of functional RNA domains such as natural protein binding motifs, artificial aptamers and small molecules with varying size. While all the complexes were functional a... | https://en.wikipedia.org/wiki?curid=53354629 |
CRISPR-Display lncRNAs used had lengths between ~90–4800 nt, and included the NoRC-binding pRNA, three enhancer-transcribed RNAs (eRNAs) FALEC, TRERNA1 and ncRNA-a3), "Xist" A-repeat (RepA), and the 4,799-nt transcriptional activator "HOTTIP". While all the constructs showed significant direct activation, it decreased ... | https://en.wikipedia.org/wiki?curid=53354629 |
CRISPR-Display One of the major outstanding questions in the study of lncRNAs is whether effects on chromatin state or gene expression adjacent to a lncRNA locus is due to functional, sequence-specific mechanisms of the lncRNA itself, or due simply to the act of transcribing the lncRNA. Localizing lncRNA to ectopic sit... | https://en.wikipedia.org/wiki?curid=53354629 |
CRISPR-Display Recruiting these proteins can allow studies of specific proteins’ and protein complexes’ effects on gene regulation and chromatin states, as well as specific regulation of certain genes for investigation of gene function. Due to the modularity of the sgRNA, several different sgRNAs with distinct function... | https://en.wikipedia.org/wiki?curid=53354629 |
Nikolaj Iljitsch Baranov (sometimes Baranoff) (1887, Oryol-1981, London) was a Russian entomologist who specialised in Diptera. His collection of Palearctic Tachinidae is held by the Smithsonian Institution Washington D.C..Baranov described many new species. He worked as an entomologist at the Institute of Hygiene in Z... | https://en.wikipedia.org/wiki?curid=53363170 |
Third-generation sequencing (also known as long-read sequencing) is a class of DNA sequencing methods currently under active development. Third generation sequencing works by reading the nucleotide sequences at the single molecule level, in contrast to existing methods that require breaking long strands of DNA into sma... | https://en.wikipedia.org/wiki?curid=53363521 |
Third-generation sequencing In order to preserve read quality, long DNA molecules must be broken up into small segments, resulting in a critical limitation of second generation sequencing technologies. Computational efforts aimed to overcome this challenge often rely on approximative heuristics that may not result in a... | https://en.wikipedia.org/wiki?curid=53363521 |
Third-generation sequencing PacBio developed the sequencing platform of single molecule real time sequencing (SMRT), based on the properties of zero-mode waveguides. Signals are in the form of fluorescent light emission from each nucleotide incorporated by a DNA polymerase bound to the bottom of the zL well. Oxford Nan... | https://en.wikipedia.org/wiki?curid=53363521 |
Third-generation sequencing Pair end reads have been leveraged by second generation sequencing to combat these limitations. However, exact fragment lengths of pair ends are often unknown and must also be approximated as well. By making long reads lengths possible, third generation sequencing technologies have clear adv... | https://en.wikipedia.org/wiki?curid=53363521 |
Third-generation sequencing In addition, since the sequencing process is not parallelized across regions of the genome, data could be collected and analyzed in real time. These advantages of third generation sequencing may be well-suited in hospital settings where quick and on-site data collection and analysis is deman... | https://en.wikipedia.org/wiki?curid=53363521 |
Third-generation sequencing Genome assembly is the reconstruction of whole genome DNA sequences. This is generally done with two fundamentally different approaches. When a reference genome is available, as one is in the case of human, newly sequenced reads could simply be aligned to the reference genome in order to cha... | https://en.wikipedia.org/wiki?curid=53363521 |
Third-generation sequencing Pair end reads have been posed as a possible solution, though exact fragment lengths are often unknown and must be approximated. Long read lengths offered by third generation sequencing may alleviate many of the challenges currently faced by de novo genome assemblies. For example, if an enti... | https://en.wikipedia.org/wiki?curid=53363521 |
Third-generation sequencing DNA modifications and resulting gene expression can vary across cell types, temporal development, with genetic ancestry, can change due to environmental stimuli and are heritable. After the discovery of DNAm, researchers have also found its correlation to diseases like cancer and autism. In ... | https://en.wikipedia.org/wiki?curid=53363521 |
Third-generation sequencing The classifier has 82% accuracy in randomly sampled singleton sites, which increases to 95% when more stringent thresholds are applied. Other methods address different types of DNA modifications using the MinION platform. Stoiber et al. examined 4-methylcytosine (4mC) and 6-methyladenine (6m... | https://en.wikipedia.org/wiki?curid=53363521 |
Third-generation sequencing Other forms of DNA modifications – from heavy metals, oxidation, or UV damage – are also possible avenues of research using Oxford Nanopore and PacBio third generation sequencing. Processing of the raw data – such as normalization to the median signal – was needed on MinION raw data, reducin... | https://en.wikipedia.org/wiki?curid=53363521 |
Third-generation sequencing According to the central dogma of molecular biology, genetic information flows from double stranded DNA molecules to single stranded mRNA molecules where they can be readily translated into function protein molecules. By studying the transcriptome, one can gain valuable insight into the regu... | https://en.wikipedia.org/wiki?curid=53363521 |
Third-generation sequencing The current generation of sequencing technologies produce only short reads, putting tremendous limitation on the ability to detect distinct transcripts; short reads must be reverse engineered into original transcripts that could have given rise to the resulting read observations. This task i... | https://en.wikipedia.org/wiki?curid=53363521 |
Third-generation sequencing For human, the study reported an exon detection sensitivity averaging to 69% and transcript detection sensitivity had an average of mere 33%. In other words, for human, existing methods are able to identify less than half of all existing transcript. Third generation sequencing technologies h... | https://en.wikipedia.org/wiki?curid=53363521 |
Third-generation sequencing The first Ebola virus (EBV) read was sequenced 44 seconds after data acquisition. There was uniform mapping of reads to genome; at least one read mapped to >88% of the genome. The relatively long reads allowed for sequencing of a near-complete viral genome to high accuracy (97–99% identity) ... | https://en.wikipedia.org/wiki?curid=53363521 |
SMiLE-Seq Selective microfluidics-based ligand enrichment followed by sequencing (SMiLE-seq) is a technique developed for the rapid identification of DNA binding specificities and affinities of full length monomeric and dimeric transcription factors in a fast and semi-high-throughput fashion. SMiLE-seq works by loading... | https://en.wikipedia.org/wiki?curid=53367602 |
SMiLE-Seq The binding of transcription factor molecules to DNA, either alone or in combination with other transcription factors, is used to control gene expression in response to both intra- and extracellular stimuli. Characterizing the binding mechanisms and specificities of transcription factors to specific regions o... | https://en.wikipedia.org/wiki?curid=53367602 |
SMiLE-Seq The development of SMiLE-seq technology has provided an attractive alternative method with the potential to facilitate identification and characterization of previously undescribed transcription factor-DNA binding interactions. SMiLE-seq uses a microfluidic device into which transcription factors, which have ... | https://en.wikipedia.org/wiki?curid=53367602 |
SMiLE-Seq The presence of DNA is confirmed by Cy5 signal detection. A polydimethylsiloxane membrane on the button surface captures successfully bound transcription factor-DNA complexes, while unbound transcription factors and targets are washed away. Following the removal of unbound components, bound DNA molecules are ... | https://en.wikipedia.org/wiki?curid=53367602 |
SMiLE-Seq The ability of many transcription factors to bind DNA is dependent on heterodimer formation, and therefore requires the presence of a specific dimer partner for binding. This has been shown to yield incomplete results if transcription factors are individually tested. Heterodimer combinations have been shown t... | https://en.wikipedia.org/wiki?curid=53367602 |
SMiLE-Seq Additionally, previous studies have shown that fluorescent protein tags can affect the binding affinity of proteins to their targets. The effect of the specific fluorescent protein tags on binding affinity would have to be investigated to determine whether this would impact specific protein-DNA interactions f... | https://en.wikipedia.org/wiki?curid=53367602 |
Al-Ashraf Umar II al‐Malik al‐Ashraf (Mumahhid al‐Dīn) ʿUmar ibn Yūsuf ibn ʿUmar ibn ʿAlī ibn Rasūl (born c. 1242, died 22 November 1296 in Yemen) was the third Rasulid sultan and a polymath. He is known for writing the first description of the use of a magnetic compass for determining the qibla. Also, his works on ast... | https://en.wikipedia.org/wiki?curid=53368843 |
NGC 423 is a lenticular galaxy of type S0/a? located in the constellation Sculptor. It was discovered on November 14, 1835 by John Herschel. It was described by Dreyer as "extremely faint, small, extended, gradually a little brighter middle, eastern of 2.", the other being NGC 418. | https://en.wikipedia.org/wiki?curid=53369366 |
John Goss-Custard Dr John D. Goss-Custard is a British behavioural ecologist; he was one of the first scientists to carry out field work on foraging behaviour making use of optimising models, specifically the optimal diet model. After completing a BSc degree in Zoology at the University of Bristol, he moved to the Univ... | https://en.wikipedia.org/wiki?curid=53384718 |
Moving the Earth farther away from the sun as the Sun grows hotter during its current hydrogen burning phase has been considered by planetary scientists, including some at Cornell University. Various mechanisms have been proposed to increase the size of the Earth's orbit. The most plausible method would involve redirec... | https://en.wikipedia.org/wiki?curid=53386033 |
Shu Jie Lam is a Malaysian-Chinese research chemist specialising in biomolecular engineering. She is researching star polymers designed to attack superbugs as antibiotics. | https://en.wikipedia.org/wiki?curid=53391053 |
J. C. Séamus Davis is an Irish physicist who is active in the field of condensed matter physics and who is well-known for low-temperature experiments, e.g. using scanning tunneling microscopy. At present he holds academic positions at Oxford, Cork, and Cornell. Davis was admitted to University College Cork (UCC) in 197... | https://en.wikipedia.org/wiki?curid=53408038 |
J. C. Séamus Davis Active research interests include studies of superconductors, superfluids and supersolids; Kondo, Weyl and Hund metals; magnetic and Kondo topological condensates; and spin & monopole liquids. For these studies, a variety of specialized instrumentation has been developed including scanning tunneling ... | https://en.wikipedia.org/wiki?curid=53408038 |
Peder Nielsen (1893-1975) was a Danish entomologist who specialised in Diptera especially Nematocera. was a librarian and museologist in Silkeborg. partial list Full list at Craneflies of the World | https://en.wikipedia.org/wiki?curid=53410460 |
NGC 5003 is a spiral galaxy in the constellation Canes Venatici. The celestial object was discovered on April 9, 1787, by the German-British astronomer William Herschel. | https://en.wikipedia.org/wiki?curid=53412666 |
José Luis Sérsic (6 May 1933 – 19 July 1993) was an Argentine astronomer who studied the morphology of galaxies. He is most widely known for the mathematical model of galaxy brightness, the Sersic profile, which bears his name. first published his law in 1963. The asteroid 2691 Sersic is named in his honour. | https://en.wikipedia.org/wiki?curid=53413142 |
Sabine Stanley is a Canadian physicist, currently at Johns Hopkins University in the Zanvyl Krieger School of Arts and Sciences Morton K. Blaustein Department of Earth And Planetary Sciences and was awarded a Bloomberg Distinguished Professorship in 2017. She was previously a Canada Research Chair of Planetary Physics ... | https://en.wikipedia.org/wiki?curid=53424910 |
Fritz Peus ( 22 April 1904, Siegen- 17 November 1978, Berlin ) full name Friedrich Ferdinand Christian Peus was a German entomologist who specialised in Coleoptera, Diptera and Siphonaptera. From 1923 to 1927 Peus studied zoology, botany and physics at the University of Münster. During the second world war, Peus was en... | https://en.wikipedia.org/wiki?curid=53425146 |
Ormdl sphingolipid biosynthesis regulator 3 ORMDL sphingolipid biosynthesis regulator 3 is a protein that in humans is encoded by the ORMDL3 gene. This gene is associated with asthma in childhood. Transgenic mice which overexpressing human ORMDL3 have increased levels of IgE. This correlated with increased numbers of m... | https://en.wikipedia.org/wiki?curid=53427212 |
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