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Controlling gene expression in primary cultured cells, such as human keratinocytes is difficult due to the stratum corneum, which ranges from 10-50 urn in thickness and serves as a barrier to the intracellular environment. Methods to introduce gene regulation agents such as oligonucleotides have met with limited succes...	{ "pile_set_name": "NIH ExPorter" }
Since auditory function can be assessed objectively by recording Auditory Evoked Potentials from the brainstem, we propose to study in term and premature neonates affected by hyperbilirubinemia. Such factors as development, hypoxia and therapy will be examined for their influences. Serum Bilirubin levels will be correl...	{ "pile_set_name": "NIH ExPorter" }
This application seeks continuing support for the on-going Chromosome Metabolism and Cancer Training Program that trains researchers exploring the links between chromosome metabolism andcancer. Advances in the studies of genes and genomes have greatly facilitated the understanding of chromosome metabolism (gene express...	{ "pile_set_name": "NIH ExPorter" }
The proposed research investigates automated, programming techniques for the objective evaluation and education, including socialization, of severely retarded children. The procedures permit full control over stimulus and reinforcing events, including social variables, and constitute a comprehensive intervention in the...	{ "pile_set_name": "NIH ExPorter" }
Overexpression of P-glycoprotein (P-gp) and/or multidrug resistance-associated protein (MRP1) is associated with resistance of tumors to a wide range of chemotherapeutic drugs. Many cancers initially respond well to chemotherapeutic treatment, but these tumors eventually become resistant to those cytotoxic drugs. Some ...	{ "pile_set_name": "NIH ExPorter" }
Project summary: The major goal of this research proposal is to elucidate the function of serotonin (5-HT) in feeding and feeding-related behaviors in Drosophila melanogaster. 5-HT affects the feeding behavior of both vertebrates and invertebrates, however the precise molecular mechanisms by which this occurs are large...	{ "pile_set_name": "NIH ExPorter" }
Potassium channels of the cardiac cell membrane play a major role in initiating and controlling the heart beat. Thus, for example, cardiac pacemaker activity is slowed by the neurotransmitter acetylcholine by way of its activation of an inwardly-rectifying potassium channel in the cll membrane. The mechanism of this ac...	{ "pile_set_name": "NIH ExPorter" }
ABSTRACT: The goal of this proposal is to provide technically-advanced support for the specific aims of NCI- funded projects for medical imaging affiliated with the University of Washington, the NCI Quantitative Imaging Network (QIN), and the NCTN ECOG-ACRIN cooperative group. My medical imaging career began at UW in 1...	{ "pile_set_name": "NIH ExPorter" }
Myeloid leukemias are characterized by aberrant blockade of differentiation due to expression of leukemic oncoproteins such as PML/RAR-alpha. Elucidation of the mechanisms responsible for normal myeloid differentiation will further our understanding of differentiation blockades in leukemias, and foster the development ...	{ "pile_set_name": "NIH ExPorter" }
Otitis media (OM) is the most common cause of acquired pediatric hearing loss and may delay language and cognitive development. It is the leading diagnosis in the U.S. for children and is the primary reason for prescribing antibiotics and performing surgery. The etiology and pathogenesis of OM are poorly understood. Th...	{ "pile_set_name": "NIH ExPorter" }
The long-range objective of the proposed research is to elucidate basic principles and mechanisms governing the prenatal and postnatal development and plasticity of prefronatal association cortex in primates. The research is composed of four integral parts: (1) analysis of the outgrowth, synaptogenesis and organization...	{ "pile_set_name": "NIH ExPorter" }
The long-range goal of the proposed research is to gain a detailed understanding of the cellular and molecular mechanisms underlying long- term potentiation (LTP) of synaptic transmission. Changes in the efficiency of transmission at synapses, such at LTP, are thought to be an important mechanism by which the function ...	{ "pile_set_name": "NIH ExPorter" }
This project involves evaluating improved man-machine interface methods and identifying ways that modern microprocessor technology might benefit physicians and the practice of medicine. Interface methods that offer promise are voice input/output, bar codes (such as used with point of sale equipment), and touch screen s...	{ "pile_set_name": "NIH ExPorter" }
The ultimate objective of this research plan is to establish a multi-disciplinary, multi-institutional Network for Translational Research to develop, standardize, validate, and optimize a targeted, multi-modal optical/nuclear imaging platform that uses labeled probes to identify dysplastic mucosa in the digestive tract...	{ "pile_set_name": "NIH ExPorter" }
This is a multi-group research study which plans to evaluate the overall progression-free survival of children with average-risk medulloblastoma treated with craniospinal radiation and local boost radiotherapy plus one of two adjuvant chemotherapy regimens differing in the replacement of CCNU by cyclophosphamide. The l...	{ "pile_set_name": "NIH ExPorter" }
Cells require ordered movement of proteins and lipids from one membrane-bound compartment to another, while maintaining the organization, function and heterogeneity of the donor and acceptor membranes;vesicular membrane traffic carries out these functions. Clathrin coated vesicles are the most prominent form of traffic...	{ "pile_set_name": "NIH ExPorter" }
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which...	{ "pile_set_name": "NIH ExPorter" }
Thermal injury represents a common form of trauma associated with significant mortality and morbidity. Despite the remarkable improvements in critical care and wound management, end-organ effects of systemic inflammatory reactions characteristic of multiple organ edema and dysfunction remain life-threatening problems i...	{ "pile_set_name": "NIH ExPorter" }
Summary of work: Most studies of age differences in personality have been conducted in the United States using self-report measures. For this project, two studies were conducted across cultures using observer ratings of personality. In the first, we obtained both self-reports and informant ratings of the same individua...	{ "pile_set_name": "NIH ExPorter" }
Hedgehog (Hh) signaling is employed in controlling cell fates in most developing tissues and organs, as well as during many regeneration events. Defects in Hh signaling lead to birth defects and cancer. Many mechanistic mysteries remain regarding how an Hh signal is transduced. Using high-throughput RNAi screening, we ...	{ "pile_set_name": "NIH ExPorter" }
The objectives of this proposal are to obtain an understanding of the selective inhibition of fat intake by enterostatin, the aminoterminal pentapeptide of pancreatic procolipase. The hypothesis to be investigated is that enterostatin is secreted in response to the intake of dietary fat and acts as a feed-back regulato...	{ "pile_set_name": "NIH ExPorter" }
This COBRE application builds on the foundation laid by the initial COBRE (RR15640). The Neuroscience COBRE has as its programmatic objective the establishment of a sustainable Center for Neuroscience. Significant progress has been made. Neuroscience was identified as one of four Areas of Distinction in the University ...	{ "pile_set_name": "NIH ExPorter" }
The goal of this proposal is to obtain mechanistic insights into the role of cardiac mitochondria in defining the substrate for atrial fibrillation (AF), the most common arrhythmia encountered in clinical practice. With a projected 6-fold increase in the prevalence and a cost exceeding $15 billion per year, AF remains ...	{ "pile_set_name": "NIH ExPorter" }
Intramuscular injections of plasmid DNA has been shown to express transgenes at relatively efficient levels. Experiments are currently underway to define the mechanism of DNA uptake by muscle cells. We would like to use the confocal microscope to examine the efficiency of nuclear uptake of DNA under various conditions ...	{ "pile_set_name": "NIH ExPorter" }
Determine if the regional cerebral blood flow (rCBF) of patients with isolated amnestic syndromes differs from that of healthy persons, particularly during performance of memory tasks.	{ "pile_set_name": "NIH ExPorter" }
The National Network of Libraries of Medicine program is intended to provide health science practitioners, investigators, educators, and administrators with timely, convenient access to information. The program is coordinated by the National Library of Medicine and carried out through a nation-wide network of more than...	{ "pile_set_name": "NIH ExPorter" }
Models of HBsAg specific cell mediated lympholysis have been developed and utilized to examine the cytotoxic T lymphocytes (CTL) in hepatitis B patients. Procedures are being developed to establish antigen specific T lymphocyte cell lines. One T cell clone has been isolated from HBV vaccine recipient by repeated altern...	{ "pile_set_name": "NIH ExPorter" }
Project Summary Synthetic inhibitors of protein-protein interactions (PPIs) are emerging as a promising approach for discovery of new therapeutics. However, despite recent progress, PPIs remain challenging targets and the in vivo potential of small molecule PPI inhibitors remains insufficiently characterized. We will d...	{ "pile_set_name": "NIH ExPorter" }
Androgen deprivation therapy (ADT) is being increasingly used as both a primary and neoadjuvant therapy for patients with localized prostate cancer (PCa). Our recent studies have demonstrated that the metabolic information provided by 3D MR spectroscopic imaging (MRSI) can improve the specificity of magnetic resonance ...	{ "pile_set_name": "NIH ExPorter" }
Unique opportunity to study 12 year old boy with pseudohypoaldosteronism, to determine 1) his sodium and potassium replacement requirements, 2) the effect of variations in intake of these ions on muscle function and endurance, 3) the effect of an angiotensin converting enzyme inhibitor on electrolyte balance, and 4) th...	{ "pile_set_name": "NIH ExPorter" }
Leydig cells within the testis are the source of androgens that promote virility at both fetal and adult stages, but Leydig cell populations are distinct at each age. As such, adult and fetal Leydig cells function to synthesize testosterone in distinct cellular and endocrine environments. The AIMs of this proposal are ...	{ "pile_set_name": "NIH ExPorter" }
SUMMARY There is an urgent need to understand the diverse mechanisms of cardiac arrhythmias that lead to sudden death and stroke, which remain major health concerns and place more than 10 million Americans at risk. The 2017 Gordon Research Conference (GRC) on Cardiac Arrhythmia Mechanisms, ?The New Basics: Model System...	{ "pile_set_name": "NIH ExPorter" }
Our objective is to examine the pattern(s) of tissue injury resulting from the activation of the efferent limb of the intestinal (or systemic) immune response by antigen challenge administered via the lumen of the gut. Based on the results of experiments performed during the previous two years of grant support, it is p...	{ "pile_set_name": "NIH ExPorter" }
Increasing evidence suggests a critical role for epigenetic mechanisms in development, stem cell physiology and cancer. Polycomb Repressive Complex 2-mediated trimethylation of histone 3 on lysine residue 27 (H3K27me3) is catalyzed by the enzyme Enhancer of Zeste 2 (EZH2). Overexpression of EZH2 is correlated with clin...	{ "pile_set_name": "NIH ExPorter" }
The 5-year survival from lung cancer has kept pace with the improvement in 5-year survival from all cancers over the last 40 years. Yet, it remains disappointingly low at -15%. This improvement in 5-year survival is a result of heightened awareness, better technology for detection, better selection of patients for vari...	{ "pile_set_name": "NIH ExPorter" }
We have developed a method to identify non-histone proteins involved in organizing the nucleoprotein fiber of metaphase chromosomes isolated from HeLa cells. The approach is to remove histones from the metaphase chromosomes by competition with polyanions such as dextransulfate and heparin. The histone-depleted chromoso...	{ "pile_set_name": "NIH ExPorter" }
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which...	{ "pile_set_name": "NIH ExPorter" }
Even in the US, infectious diseases are the third most common cause of death, despite the widespread availability of antibiotics, vaccines, and advanced hygienic standards. The identification of new pathogens, the re-emergence of old pathogens, and the increasing incidence of antibiotic resistance reflect the globaliza...	{ "pile_set_name": "NIH ExPorter" }
DESCRIPTION: Ebola viruses (EBOV) and Marburg virus (MARV) are two genera of enveloped viruses that constitute the family of Filoviridae. Outbreaks of fulminant hemorrhagic fever in human and non-human primates in Central Africa caused by EBOV have reached mortality rates of up to 90% in the past and the mortality rate...	{ "pile_set_name": "NIH ExPorter" }
The effect of immunostimulation will be tested as an adjunct to surgical resection in thoracic surgical patients with no evident disease after surgical removal of their tumors. As an extension of our prior studies with intrapleural BCG immunostimulation, patients with resectable cancers of the lung and esophagus will b...	{ "pile_set_name": "NIH ExPorter" }
Animal replication-dependent histone mRNAs are the only eukaryotic mRNAs that lack a polyA tail ending instead in a conserved stemloop. In contrast mRNAs for histone variants, e.g. H3.3 and H2.v, are encoded by polyadenylated mRNAs. The genes for all five histone proteins are clustered in metazoan genomes, and factors ...	{ "pile_set_name": "NIH ExPorter" }
Project Summary/Abstract Over the last two decades, many giant DNA viruses have been discovered, some of which are bigger than a small cell. How these giant viruses assemble their virion shell from thousands of simple protein building blocks so precisely is a mystery. However, the sheer size of these viruses poses a si...	{ "pile_set_name": "NIH ExPorter" }
This application proposes a supplement to the NBER's ongoing program project on the Economics of Aging. In particular, it proposes a continuation of the subproject on "Improving Data Measurement in Surveys of the Elderly" for the final two years of the current PO1 award period. Accurate responses to surveys of elderly ...	{ "pile_set_name": "NIH ExPorter" }
Hepatitis C virus (HCV) often causes a prolonged and persistent infection, and an association between hepatocellular carcinoma (HCC) and HCV infection has been noted. Understanding the molecular basis of viral pathogenesis is a major challenge in the effort to gain insight into HCV associated disease progression. The p...	{ "pile_set_name": "NIH ExPorter" }
this proposal will complete preclinical toxicity testing and safety assessment of i.t. Amitriptyline. We will test its effect on acute nociceptive pain alone, its interaction with iv alfentanil in acute nociceptive pain, and its efficacy alone against intradermal capsaicin-induced hyperalgesia and allodynia in humans. ...	{ "pile_set_name": "NIH ExPorter" }
The objective of this program is to prepare post-doctoral trainees to establish independent research careers in the areas of gonadal function, early pregnancy and embryonic development through implantation. The training program will consist of three elements;independent laboratory research, group seminars and other fun...	{ "pile_set_name": "NIH ExPorter" }
PROJECT SUMMARY Experimental models and human studies have repeatedly linked persistent organic pollutants (POPs) such as perfluorinated alkylate substances (PFASs) and polychlorinated biphenyls (PCBs) to abnormal fat distribution, body mass index, and glucose and lipid metabolic abnormalities during early life. These ...	{ "pile_set_name": "NIH ExPorter" }
The purpose of the proposed project is to test a theoretical model of HIV/AIDS disclosure that simultaneously examines multiple factors hypothesized to predict and inhibit disclosure and tests the relationships between disclosure events and psychological and behavioral outcomes. To date, there exists no known model tha...	{ "pile_set_name": "NIH ExPorter" }
During oogenesis and maturation of the sea urchin egg, large stores of mRNA are accumulated for subsequent use during early embryogenesis. Utilization of stored maternal mRNA occurs at a very low rate prior to fertilization. After fertilization, dramatic changes in mRNA availability and recruitment occur, allowing rapi...	{ "pile_set_name": "NIH ExPorter" }
The trigeminal mesencephalic nucleus, main sensory nucleus, and rostral part of the spinal sensory nucleus of cats will be stereotaxically explored with extracellular microelectrodes to determine the location and firing patterns of single neurons which respond to passive movement of the condylar head of the mandible wi...	{ "pile_set_name": "NIH ExPorter" }
The primary symptoms of hypoparathyroidism include muscle cramping, convulsions, intellectual disabilities, cataracts and abnormal heart rhythm. Symptoms are due to low serum calcium (hypocalcemia). Replacement of parathyroid hormone (PTH) has been explored to remedy the calcium deficiency, but maintaining an optimal c...	{ "pile_set_name": "NIH ExPorter" }
The long range goal of this work is to study the molecular basis of membrane-cytoskeleton associations and their role in the directed intracellular movements of membranes and organelles. Specifically, it is planned to investigate the idea that actin filament-membrane attachments are instrumental in the translocation of...	{ "pile_set_name": "NIH ExPorter" }
Talk given for the second MSA (Microscopy Society of America) Workshop on Multiphoton Excitation Microscopy (Atlanta, 12 July 1998). The topics described were aspects associated with multiphoton imaging down in the 700-800nm region: UV excitable probes, tissue autofluorescence and cell viability under the imaging condi...	{ "pile_set_name": "NIH ExPorter" }
(Adapted from the Applicant?s Abstract) The purpose of the core is to provide the resources and expertise for the efficient generation and delivery into embryos of recombinant expression viruses (adenovirus and retroviruses) containing genes of interest to the project investigators. (End of Abstract) This core provides...	{ "pile_set_name": "NIH ExPorter" }
Haemophilus influenzae is an important cause of human disease, producing both localized respiratory tract and systemic (bacteremic) infections. The initial step in the pathogenesis of disease due to this organism involves colonization of the upper respiratory tract. Despite the essential role of colonization, the deter...	{ "pile_set_name": "NIH ExPorter" }
The objectives of these studies are to define which subcellular constituents of animal and human granulocytes possess biologically active substances affecting blood coagulation, to determine if subcellular fractions of macrophages have these same biological activities, and to examine the influence of endotoxin and cert...	{ "pile_set_name": "NIH ExPorter" }
The goal of this research is to devise automated methods of analyzing the Auditory Brainstem Response (ABR) when it is recorded using three orthogonal channels. The resulting 3-Channel Lissajous Trajectory (3-CLT) shows both linear and planar portions, which will be detected using algorithms tested under realistic cond...	{ "pile_set_name": "NIH ExPorter" }
Iron is essential for cell growth and division, but it is also harmful when it accumulates in cells. Therefore, the intracellular level of iron must be precisely regulated. Iron-overload diseases are primarily caused by hereditary hemochromatosis (HH)-the most common genetic disorder in Europe and the United States. Th...	{ "pile_set_name": "NIH ExPorter" }
The contractor will perform laboratory assays to provide information on the relationship of virus and tumor associated antigens to the etiology of human cancer. Most of these studies which will be predominantly utilizing cell-mediated immunity assays, will be performed in collaboration with ongoing contracts within the...	{ "pile_set_name": "NIH ExPorter" }
My goal is to determine, using NMR, the structure of a vaccinia virus DNA sequence containing two extrahelical bases (G and C) on the same strand, separated by d(AA).d(TT). It appears at each terminus of the genome, with the extrahelical bases at corresponding locations but as complements. I am testing alternative stru...	{ "pile_set_name": "NIH ExPorter" }
Significant progress was made during this reporting period. In collaboration with Dr. Blough, we continued to evaluate a large number of newly synthesized compounds using in vitro assays. The current focus is on DA/5-HT releasers based on the phenmetrazine structure, since these compounds have minimal activity at the 5...	{ "pile_set_name": "NIH ExPorter" }
The long-term objective of the proposed research is to elucidate the mechanisms by which neuronal activity shapes synaptic connections during development of the visual system in mammals. The goal of the present application is to examine the role of nitric oxide (NO) and its downstream signaling pathways in the formatio...	{ "pile_set_name": "NIH ExPorter" }
C-11 alpha-methyl-L-tryptophan (AMT) is being used to assess the turnover of serotonin, a major transmitter in the brain that is linked to depression and impulsive behavior. Studies are being conducted with the tracer in monkeys before its use in humans. The monkeys being studied have high or low levels of aggressive b...	{ "pile_set_name": "NIH ExPorter" }
This study addresses how parents'discipline strategies affect children's development. The first and second aims are to examine whether the association between harsh discipline and child adjustment is moderated by: 1) the normativeness of the discipline method as indicated by cultural acceptance of its use, and 2) the a...	{ "pile_set_name": "NIH ExPorter" }
The purpose of this contract is to provide research and development support for the Unified Medical Language System. Specifically, the contractor will support (1) the definition of the functional components and algorithms needed: to relate the user's terms to information in the UMLS Knowledge Sources; to interact with ...	{ "pile_set_name": "NIH ExPorter" }
Cardiovascular disease (CVD) is the leading cause of death in both men arid women. Magnetic resonance imaging (MRI) is a highly promising imaging modality for the detection and characterization of CVD. 1 of the major MRI tests that has found widespread clinical application is the dynamic (cine) imaging of cardiovascula...	{ "pile_set_name": "NIH ExPorter" }
A study of radiation effects is proposed which will employ electron spin resonance (ESR) spectroscopy and electron-nuclear double resonance (ENDOR) spectroscopy to identify direct radiation damage in irradiated single crystals of biomolecules. A principal objective will be to synthesize and crystallize DNA oligomers of...	{ "pile_set_name": "NIH ExPorter" }
The goal of this project is to develop a c-jun N-terminal kinase 2/3 (JNK2/3) inhibitor that may be used in the treatment of neurodegeneration in Parkinson's disease (PD). Development of a drug that prevents dopaminergic neurodegeneration would be first in class for halting progression of the disease and a clinical com...	{ "pile_set_name": "NIH ExPorter" }
The purpose of these studies is to develop a pig animal model of Spinal Muscular Atrophy (SMA) whereby the development and testing of therapeutics can be efficiently accomplished. SMA, the most common inherited motor neuron disease, occurs in ~1:8,000 live births and has a carrier frequency of ~1:40; however, no cure e...	{ "pile_set_name": "NIH ExPorter" }
The mechanisms by which neuronal pathways are established are not well understood. One theory states that pathways are first laid out by pioneer neurons and that subsequent axons travel along them. This pattern has yet to be demonstrated in the vertebrate CNS. I will test this theory by examining development of descend...	{ "pile_set_name": "NIH ExPorter" }
DESCRIPTION: (Applicant's Abstract) The aim of this project is the development of theory-based strategies that foster construction of anti-drug communications tailored specifically to the particular psychology of the adolescent. Acknowledging the adolescent's growing need for individuation, control, and autonomy, this ...	{ "pile_set_name": "NIH ExPorter" }
The current project examines the use of calcipitrol to improve diffusion of gemcitibine into the cancer. Studies examine the effect on vasculature and the potential increase in efficacy of gemcitibine to reduce cancer burden in mouse model. Cohorts of 10-15 mice each are nrolled ito preclinical trials by imaging with u...	{ "pile_set_name": "NIH ExPorter" }
Neariy half of CAIR's extramural research is now in the international arena, chiefly in former Soviet countries. International HIV prevention studies have specialized research support needs, and CAIR's development of vigorous, successful line of internafional research, service, and training activifies[unreadable]all in...	{ "pile_set_name": "NIH ExPorter" }
Insulin resistance and hyperinsulinemia are critical to the development of type 2 diabetes mellitus. The pathogenesis, however, of the multiple complications and conditions associated with this disease such as increased risk for and decreased recovery from stroke is not yet understood. Chronic inflammation is a promine...	{ "pile_set_name": "NIH ExPorter" }
A small subpopulation within NINCDS Collaborative Perinatal Project children has been identified as being of mixed black and white parentage. Within the interracial group of matings there is no evidence that genetic or socio-economic differences are related to race of mother (or father). Thus socio-psychological influe...	{ "pile_set_name": "NIH ExPorter" }
This is an application to renew a K24 Mid-Career Investigator Award in aging-related patient-oriented research. The Awardee is a professor of psychiatry, neurology, and epidemiology with an established track record as a researcher, clinician, and educator. The Awardee's current research focus is on mild cognitive impai...	{ "pile_set_name": "NIH ExPorter" }
Our long term objective is to investigate the molecular mechanisms that control the proliferation and differentiation of human neural crest stem cells (hNCSCs) and use these cells for regenerative medicine. Embryonic NCSCs are pluripotent and NCSCs have been shown to persist in the adult in at least two differentiated ...	{ "pile_set_name": "NIH ExPorter" }
In the last two decades though the field of neuroprosthetics has gained tremendous momentum through the development of novel architectures for neural interfaces, however, till date there is no device which can be nomenclatured as the gold standard in the field. As a result the research and technology environment at eac...	{ "pile_set_name": "NIH ExPorter" }
OBJECTIVES: a) The overall objective of this entire research project is to purify sufficient quantities of D-lactic dehydrogenase from two strains of Moraxella (ATCC19965, 19975) from one strain of Neisseria (ATCC8193) and anthranilate synthetase from Moraxella (ATCC19965) for the preparation of rabbit antibody specifi...	{ "pile_set_name": "NIH ExPorter" }
: U6 small nuclear RNA (U6 snRNA) is a component of eukaryotic spliceosomes and is required for splicing of nuclear pre-messenger RNAs. It has been suggested that U6 RNA may be directly involved in catalysis during nuclear pre-mRNA splicing. U6 RNA, besides being the most conserved of all U snRNAs, is unique in many re...	{ "pile_set_name": "NIH ExPorter" }
There is concern about the misuse and abuse of benzodiazepine anxiolytic/sedative drugs which are among the most widely used of all medically prescribed compounds. Caffeine is the single most widely used behaviorally active drug and there is increasing concern that a significant proportion of the population may be at h...	{ "pile_set_name": "NIH ExPorter" }
This project involves the study of the effects of antibiotics on bacterial infections in 100 women undergoing elective hysterectomy in the Yale-New Haven Hospital from 1973 to 1977. Antibiotics used were Penicillin and Cefazolin. Staff members of OBE are collaborating on the extensive data analysis, including multivari...	{ "pile_set_name": "NIH ExPorter" }
Leucocytes from a total of 212 patients have been assayed against an antigen derived from pancreatic adenocarcinoma. Results, to date, have indicated that the leukocytes from 11 of 12 patients whose cancer are localized or confirmed to lymph nodes adjacent to the pancreas have identified the antigen, whereas leukocytes...	{ "pile_set_name": "NIH ExPorter" }
The major objective and principal scientific challenge of this proposal is the implementation of new methodology for the stereocontrolled synthesis of building blocks for a number of biologically important natural products, based on novel organomolybdenum chemistry. Some key targets chosen so as to highlight the consid...	{ "pile_set_name": "NIH ExPorter" }
Recently, major advances have been made in elucidating both the genetics and biochemistry of chloroquine resistance as well as in elucidating the atomic level interactions between chloroquine and its principle target, uncrystallized heme. In the former, groundbreaking advances by the Wellems lab have expanded into a se...	{ "pile_set_name": "NIH ExPorter" }
Project Summary/Abstract Endometriosis, a chronic gynecological disorder defined as the presence of endometrial glands and stroma outside the endometrial cavity, is characterized by peritoneal inflammation, fibrosis, adhesions and ovarian cysts. Patients suffer from chronic pelvic pain, pain during intercourse, painful...	{ "pile_set_name": "NIH ExPorter" }
The mission of the Developmental Therapeutics Program (DTP) is the development of novel synthetic and characterized natural products as potential anti-cancer agents. Towards this mission the contract will be devoted to the synthesis of small molecules needed by the various programs of the Division of Cancer Treatment a...	{ "pile_set_name": "NIH ExPorter" }
Approximately 60% of the U.S. population is overweight or obese, and obesity has been linked to numerous health problems. Physical activity has been recommended for overweight and obese adults to enhance weight- loss and/or weight-maintenance, and to reduce risk of chronic disease, including heart disease and cancers o...	{ "pile_set_name": "NIH ExPorter" }
Previous studies have demonstrated that intracellular Cs2+ overload plays an important role in myocardial ischemic injury, and that an important determinant of Ca2+ homeostasis is the control of intracellular Na+ (Na+). However, Na+ homeostasis during ischemia is still poorly understood. The proposed project will emplo...	{ "pile_set_name": "NIH ExPorter" }
Type 2 diabetes, obesity, and hypertension are highly prevalent in Western society and increasingly prevalent in the developing world. Abundant clinical and basic research suggests that insulin resistance (IR) underlies each of these disorders and emerges in response to the environmental stresses of Western diet and di...	{ "pile_set_name": "NIH ExPorter" }
Research suggests that clinical research subjects often fail to appreciate significant elements of what their informed consent because of the "therapeutic misconception." The therapeutic misconception involves patient/subjects failing to grasp the difference between participating in a clinical research project and rece...	{ "pile_set_name": "NIH ExPorter" }
The long-term objective of this project is to obtain detailed biochemical information and understanding of the metabolism of acetate in the strictly anaerobic microorganism Methanosarcina barkeri. Specific goals are concerned with determination of structural and catalytic properties of a high molecular mass multienzyme...	{ "pile_set_name": "NIH ExPorter" }
Immunotoxins combine the activity of a powerful toxin with an antibody capable of delivering the conjugate to a specific target cell. These compounds have proven effective in the in vitro elimination of a number of cell types, including leukemia cells and the bone marrow cells implicated in graft vs. host disease. Immu...	{ "pile_set_name": "NIH ExPorter" }
The Child Care and Development Block Grant (CCDBG) Act of 2014 incorporated several statutory changes intended to promote child well-being. One of those changes, a longer redetermination period, was intended to lead to longer program participation spells, more stable usage of high quality childcare arrangements, and mo...	{ "pile_set_name": "NIH ExPorter" }
This proposal is to implement the techniques of sensitivity analysis as a means to 1) quantatitvely assess the relationship between the potential and the observables calculated using molecular mechanics and dynamics; and 2)to quantitatively assess the relationship between the function of a biomolecule and its structure...	{ "pile_set_name": "NIH ExPorter" }
The goal is to develop improved diagnostic imaging agents for human melanoma based on a radiolabeled monoclonal antibody. P97 is an oncofetal antigen present on human melanoma tumor cells. Studies in nude mice have shown there is active concentration of anti-p97 antibody and Fab fragments directed against p97 antigen o...	{ "pile_set_name": "NIH ExPorter" }
Integrins are transmembrane heterodimeric glycoproteins composed of 1 and 2 subunits that mediate the interactions between cells and extracellular matrix (ECM). In humans there are 18 1 and 8 2 subunits, which combine in a restricted manner to form dimers, each of which exhibit different ligand binding properties. Inte...	{ "pile_set_name": "NIH ExPorter" }
The project represents a continuation of the investigation into the variables related to the development of the optical and refractive characteristics of the human and sub-human primate eyes. Since the work to date indicates that nearwork plays a considerable role in the development of myopic refractive characteristics...	{ "pile_set_name": "NIH ExPorter" }
The majority of breast cancers are diagnosed as breast cancer of no specific type (or ductal carcinoma), a heterogeneous category of tumors that includes curable neoplasms as well as highly aggressive cancers. This classification is inadequate for clinical management of breast cancer patients as well as for designing l...	{ "pile_set_name": "NIH ExPorter" }
The Women's Health Initiative is a randomized controlled clinical trial conducted in 40 clinical centers across the United States addressing some of the most common causes of death, disability, and impaired quality of life in postmenopausal women ages 50-79; cardiovascular disease; breast and colon cancer; and osteopor...	{ "pile_set_name": "NIH ExPorter" }

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