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The interaction of anthracycline drugs and selected model compounds with DNA will be investigated by physical techniques including 31P,13C, and 1H NMR, viscosity, u.v.-visible spectroscopy, ultracentrifugation, and equilibrium dialysis. The general goal of these studies is to evaluate structural and thermodynamic aspec...	{ "pile_set_name": "NIH ExPorter" }
Colony-stimulating factor 1 (CSF1) is the principal colony-stimulating factor produced by osteoblasts constitutively and in response to several hormones and cytokines. It is absolutely required for osteoclastogenesis, but its role in regulating mature osteoclast function remains unclear. In vitro, it is known to prolon...	{ "pile_set_name": "NIH ExPorter" }
This project continues to investigate the immune responses, particularly the thymus-dependent phenomenon of contact hypersensitivity. We will continue to investigate the mechanisms of the development of contact sensitization. We will follow up on our studies of the induction of specific immunologic tolerance and its me...	{ "pile_set_name": "NIH ExPorter" }
The long term goal of this project is to understand at the cellular level how hormones (steroids and peptides) regulate nervous system development and function. These classes of hormones have profound effects on the nervous system of most animals ranging from lower invertebrates up to humans. The metamorphosis of the n...	{ "pile_set_name": "NIH ExPorter" }
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which...	{ "pile_set_name": "NIH ExPorter" }
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which...	{ "pile_set_name": "NIH ExPorter" }
It is widely recognized that colorectal cancer (CRC) is one of the most preventable cancers. If adenomatous polyps detected by screening were removed before they transformed into cancers, a decrease in new CRCs and in related mortality would follow. Unfortunately, cancer screening rates are low throughout Appalachia, i...	{ "pile_set_name": "NIH ExPorter" }
System justification theory proposes that individuals develop belief systems to explain and legitimize existing status differences between groups in societies. Although people differ in the extent to which they endorse system-justifying beliefs, research shows they are widely endorsed and have important implications fo...	{ "pile_set_name": "NIH ExPorter" }
DESCRIPTION: Bacterial resistance to beta-lactam antibiotics continues to become more prevalent and more clinically important. A large part of the resistance can be understood and investigated experimentally in terms of the chemistry of the interactions of beta-lactam antibiotics with the active sites of two groups of ...	{ "pile_set_name": "NIH ExPorter" }
We are investigating a new experimental approach for the treatment of malignant brain tumors which utilizes a new class of potent, targeted anticancer compounds, called immunotoxins. We have initiated a dose escalation trial of regional therapy with the immunotoxin transferrin-CRM107 (Tf-CRM107) for the treatment of re...	{ "pile_set_name": "NIH ExPorter" }
Deciphering the extra-telomeric function of Rap1, a metabolic regulator counteracting obesity Agnel Sfeir Project Summary: The telomere-binding protein Rap1 is part of the protective protein complex that binds mammalian telomeres. It was recently found to have additional non-telomeric functions, acting as a transcripti...	{ "pile_set_name": "NIH ExPorter" }
The proposed research will utilize nuclear magnetic resonance relaxation techniques, some of which are being developed in this lab, to elucidate our understanding of the conformational flexibility of proteins and nucleic acids. Although few details are known about the conformational flexibility of biopolymers, it appar...	{ "pile_set_name": "NIH ExPorter" }
There is a great need to develop new techniques for preparing blood samples. In clinical laboratories, preparing plasma for analysis is one of the most time consuming and dangerous tasks a technician faces. Since centrifugation is a part of the present problem, we propose to devise a system for preparing plasma by filt...	{ "pile_set_name": "NIH ExPorter" }
Essential hypertension is typically thought to attack the brain late in its course, primarily through stroke. Accumulating evidence from both human and animal studies, though, shows that essential hypertension is associated with mild cognitive deficits, altered cerebral blood flow, decreases in grey matter volume, alte...	{ "pile_set_name": "NIH ExPorter" }
The proposed study will extend an innovative investigation of biologic markers for autism using archived prenatal and newborn specimens from mother-baby pairs. Funded by the NIMH (R01 MH72565) for an initial three-year period, this project, known as the Early Markers for Autism (EMA) Study, is the first large, populati...	{ "pile_set_name": "NIH ExPorter" }
Organelle identity and development rely on a complex set of intracellular protein trafficking systems that mediate the specific targeting of nucleus-encoded proteins to their proper subcellular compartment. Not only must these trafficking systems maintain a high degree of specificity, they often must adapt to accommoda...	{ "pile_set_name": "NIH ExPorter" }
The need for a reliable method for estimating dietary consumption in the past has become critical in case referent epidemiological studies of the relationship of diet to cancer. The research objective of this study is to estimate the reliability of estimates of past dietary intake which are derived from present diet hi...	{ "pile_set_name": "NIH ExPorter" }
Current projections indicate that the number of individuals 65 years and older is expected to double by the year 2030. Because thoracic aortic aneurysm (TAAs) occur most frequently in persons 60-70 years of age, it follows that over the next two decades the frequency of aneurysm disease diagnosis is going to increase d...	{ "pile_set_name": "NIH ExPorter" }
Trichotillomania (TTM) is a chronic impulse-control disorder involving the repetitive pulling and removal of one's hair that results in notable hair loss. A growing body of research has noted the public health significance of the disorder. TTM can result in a variety of debilitating physical, psychosocial, occupational...	{ "pile_set_name": "NIH ExPorter" }
ABSTRACT Melanoma is a major world health problem with an incidence rate that is rising rapidly. Within the past several years, there has been tremendous progress in novel melanoma therapies ? particularly with regard to immunotherapy as highlighted by the FDA approval of ipilimumab (anti-CTLA-4 antibody) in 2011 and p...	{ "pile_set_name": "NIH ExPorter" }
We are currently discussing possible new vaccine candidates for therapy of herpes simplex, and planning new clinical trials.Among these is a live, replication-defective HSV-2 vaccine that we showed this past year to be effective in the immunotherapy of genital herpes in the gunea pig model.	{ "pile_set_name": "NIH ExPorter" }
Phase I study to determine the safety, tolerance, and pharmacokinetic profile, biological effects, and maximally tolerated dosage level of escalating of both recombinant human tumor necrosis factor and Cisplatin administration by i.v. route to patients with histologically documented solid tumors resistant but non-amena...	{ "pile_set_name": "NIH ExPorter" }
This application represents the first competing renewal of our program project, which uses an interdisciplinary team approach to address the unifying hypothesis that most, if not all, aging-related neurodegenerative disorders are caused by the intracellular or extracellular accumulation of specific proteins that have a...	{ "pile_set_name": "NIH ExPorter" }
To determine whether mixed Beta, alpha-adrenergic stimulation of fat from upper body and leg fat in women and me compared with pure Beta-adrenergic stimulation.	{ "pile_set_name": "NIH ExPorter" }
Project Summary. Increased lung microvascular permeability, resulting in protein-rich alveolar edema and chronic inflammation, causes ARDS (Acute Respiratory Distress Syndrome), the lethal form of acute lung injury (ALI). During the last funding cycle, we demonstrated that endothelial cell (EC)-specific deletion of foc...	{ "pile_set_name": "NIH ExPorter" }
This project proposes to continue our studies on Carbohydrate Binding Protein 35 (CBP35), a predominantly intracellular lectin that binds to galactose-containing glycoconjugates. The polypeptide (M/T about 35,000) consists of two domains: a proline- and glycine-rich domain at the NH2- terminal half and a carbohydrate r...	{ "pile_set_name": "NIH ExPorter" }
This study aims to develop a more efficient and timely system for assessing renal function and acute change in renal function. It proposes to determine if any of four commercially available grades of technetium 99mTc-DTPA can be used to provide good estimates of GFR. Clearance results from these four chelates of techne...	{ "pile_set_name": "NIH ExPorter" }
This proposal aims at the design, preparation, and testing of microfluidic devices containing porous polymer monoliths that will provide unmatched performance in "sample preparation" and the identification of proteins in complex mixtures and enable full exploitation of the rich potential of proteomic research. It will ...	{ "pile_set_name": "NIH ExPorter" }
The overarching goal of this research is to integrate family systems and developmental psychopathology theory and research to understand the processes underlying the association between destructive marital conflict and children's mental health with a specific emphasis on the role that sibling relationships play for und...	{ "pile_set_name": "NIH ExPorter" }
Prescription drugs have become an increasingly important component of mental health treatment and the costs of psychotropic drugs have increased rapidly in recent years. However, there are major gaps in our knowledge about the economics of psychotropic drug treatment. This Mentored Research Scientist Development Award ...	{ "pile_set_name": "NIH ExPorter" }
Thyroid hormones stimulate growth of normal and malignant cells, and influence metabolism and development. They are, therefore, excellent signals to study as a model for understanding general features of regulation of these processes in mammalian systems. In the proposed studies, we plan to investigate the molecular me...	{ "pile_set_name": "NIH ExPorter" }
This research proposes to construct and analyze a longitudinal model of the relationship between family composition and the labor force participation of married women. The model will be estimated for two separate cohorts of women drawn from the National Longitudinal Surveys. Family composition is conceptualized as a dy...	{ "pile_set_name": "NIH ExPorter" }
Morphometry and Physiology Core. The purposes of Core C are to evaluate the morphometric changes that occur during graft arteriosclerosis (GA) that culminate in constrictive remodeling and to assess the vasomotor function during the progression of GA in vitro. The combination of histological assessment and morphometric...	{ "pile_set_name": "NIH ExPorter" }
The Resource catalogs gene expression data in the endometrium. The EDR has established a List of genes whose expression has been associated with uterine function. Currently, this list includes 1262 genes. This list is divided by species. The genetic information has been accumulated for human, mouse, monkey, rat, rabbit...	{ "pile_set_name": "NIH ExPorter" }
This is a revised competing renewal application for an environmental toxicology training program for 6 pre-doctoral and 3 postdoctoral fellows. Since this program started in 1990, training has been provided to 9 postdoctoral fellows and 29 pre-doctoral fellows. The 14 trainees who have completed their formal education ...	{ "pile_set_name": "NIH ExPorter" }
Although lithium displays remarkable mood-stabilizing properties and has served as one of the most effective therapies for bipolar disorder (BPD), the mechanisms underlying its actions on the nervous system remain unclear. The long-term goal of this project is to understand-at the molecular and cellular levels-how lith...	{ "pile_set_name": "NIH ExPorter" }
The overall objective of this competing R01 renewal is the continued development of the Elastin Fusion Protein technology as a genetically encodable, bioinspired analog of "smart" -stimulus responsive- protein-polymer conjugates. In this renewal application, we seek to greatly expand upon our ability to modulate the so...	{ "pile_set_name": "NIH ExPorter" }
Stroke is the 3rd leading cause of death and one of the leading causes of adult long-term disability in the US, with high impact for African Americans. Since 90% of stroke survivors are functionally impaired, improving stroke outcomes is a major public health issue. Agencies such as CMS and the Joint Commission have im...	{ "pile_set_name": "NIH ExPorter" }
The overall goal of this project is to characterize and stimulate the control of phonation in vocal tremor. The working hypothesis around which the project is organized proposes the vocal tremor results from modulation of vocal fold vibration due to an interaction between central and peripheral oscillators that control...	{ "pile_set_name": "NIH ExPorter" }
This application targets the millions of patients suffering from bladder disease/dysfunction related to congenital anomalies, cancer, infection, inflammation or lesions of the central or peripheral nervous system. Regardless of etiology, in all cases these conditions eventually result in largely irreparable damage to b...	{ "pile_set_name": "NIH ExPorter" }
This project is concerned with an analysis of the activity of nerve cells in that system within the primate brain which is necessary and responsible for the process we refer to as attention. Monkeys trained to perform visualy-guided go-no go discrimination tasks are tested whilst extra cellular recordings are made from...	{ "pile_set_name": "NIH ExPorter" }
Hypertension (HTN) is the most prevalent modifiable risk for cardiovascular disease (CVD) and disorders directly influencing CVD (i.e. diabetes, chronic kidney disease, obstructive sleep apnea, etc.). Despite lifestyle changes and advances in drug therapy, ~20% of all HTN patients are resistant to (or require ?3) antih...	{ "pile_set_name": "NIH ExPorter" }
The adipocyte hormone leptin regulates energy balance, substrate metabolism, immunity, bone formation and reproduction. Our recent work demonstrates that leptin production is regulated at the translational level, and that elements within its 5' UTR stimulate and its 3' UTRs inhibit translation of a reporter gene. The m...	{ "pile_set_name": "NIH ExPorter" }
Many oncoproteins and tumor suppressive proteins shuttle between the cytosol and nucleus and thus interact with changing sets of protein partners in different sub-cellular compartments. Furthermore, increasing evidence indicates that oncogenic mutations of these proteins can result in alteration of cellular localizatio...	{ "pile_set_name": "NIH ExPorter" }
An estimated 5.3 million Americans are currently suffering from Alzheimer's disease (AD), and AD cases are expected to rise at an alarming rate (AD;Alzheimer's Association, 2010). Therefore, market potential exists for products, approaches, and/or training that can help treat and/or circumvent the challenging behaviors...	{ "pile_set_name": "NIH ExPorter" }
The purpose of this project is to delineate the mechanisms involved in regulating immune responses in filarial and nonfilarial disease states. Immunoregulatory studies have examined the phenomenon of antigen-specific anergy in microfilaremic patients by showing this anergy to be a result of the production of the antipr...	{ "pile_set_name": "NIH ExPorter" }
Gastric adenocarcinoma is the second leading cause of cancer-related death in the world. H. pylori is the strongest known risk factor for this malignancy, yet only a fraction of infected persons ever develop cancer. One H. pylori determinant that augments cancer risk is the cag pathogenicity island, and several cag gen...	{ "pile_set_name": "NIH ExPorter" }
Ubiquitous and secure access by physicians to a patient's medical records regardless of geographic location has tremendous potential to improve the delivery of medical care along multiple dimensions, yet the lack of a unique patient identifier between institutions remains a critical obstacle. While a national patient i...	{ "pile_set_name": "NIH ExPorter" }
Abstract Lateral ankle inversion sprains occur frequently in sports and recreation activities. Although many patients relatively recover after their first acute injury, chronic ankle instability is often reported after ankle sprains despite treatment. Chronic ankle instability includes mechanical instability and functi...	{ "pile_set_name": "NIH ExPorter" }
The small intestine contains a significant number of intraepithelial T cells (IELs) that express CD8?? homodimer and ??TCRs. Currenlty these cells function and antigenic specificities remain enigmatic. Our long term goal is to understand how these cells contribute to homeostatic balance in the intestine, and how their ...	{ "pile_set_name": "NIH ExPorter" }
Aggregatibacter actinomycetemcomitans is a gram negative pathogen that is the etiologic agent of localized aggressive periodontitis (LAP) and other systemic infections, including infective endocarditis. LAP, a disease which affects medically-underserved children in both the United States and throughout the world, is ch...	{ "pile_set_name": "NIH ExPorter" }
The broad goal of this research is an increased understanding of the relationship between personality factors and coronary heart and coronary artery disease. Subjects will consist of cardiac patients with angiographically documented coronary disease and a matched group of apparently healthy men, some of whom are at ris...	{ "pile_set_name": "NIH ExPorter" }
Epilepsy is a disease affecting 1-2% of the population. Electrical recordings from chronic animal models and human neocortical epileptic foci indicate that the population of neurons underlying each interictal epileptiform discharge varies over time. The spatial relationship between interictal events and the ictal onset...	{ "pile_set_name": "NIH ExPorter" }
Neutral endopeptidase 24.11 (NEP) is a cell-surface peptidase expressed by prostatic epithelial cells which cleaves and inactivates neuropeptides implicated in the growth of androgen-independent prostate cancer (PC). We show that NEP expression and catalytic activity are lost in vitro in androgen-independent but not an...	{ "pile_set_name": "NIH ExPorter" }
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which...	{ "pile_set_name": "NIH ExPorter" }
This study uses a prospective, longitudinal design to determine the impact of grade retention in the early elementary grades on children's academic, behavioral, emotional, and social adjustment during the transition from elementary school to middle and high school. Participants will be recruited from the 679 children [...	{ "pile_set_name": "NIH ExPorter" }
Information about fast axonal transport in normal and/or diseased mammalian axons (including human) and the regulation of this process is limited. Until this basic information is established, the physiology and pathophysiology of this phenomenon cannot be fully elucidated. We have an opportunity to obtain new basic inf...	{ "pile_set_name": "NIH ExPorter" }
Project Summary Vector-borne Disease Research Training Program in China This research training application seeks funding to promote career development and capacity building in vector biology research in China. Vector-borne diseases are a major public health problem in China and vector control represents the most effect...	{ "pile_set_name": "NIH ExPorter" }
It is proposed to develop and test the xenon atom as a probe of biological microstructure using nuclear magnetic resonance (NMR) spectroscopy. Systems to be investigated might include simple aqueous systems, micellar solutions, vesicles, multilamellar liposomes, and proteins. The techniques to be used for this investig...	{ "pile_set_name": "NIH ExPorter" }
A continuing focus of the project this year was the investigation of ways to improve the retrieval accuracy of DELTA-BLAST through the use of model surgery and of asymmetric but uniform gap costs. Traditionally, PSI-BLAST constructs its position specific score matrix (PSSM) using the query sequence as a template, with ...	{ "pile_set_name": "NIH ExPorter" }
The major goal of this project is to determine whether PET scans ( 18F) fluorodeoxyglucose (PET-FDG) to measure metabolic rate for glucose and (11C)-PK 11195 to assess peripheral benzodiazepine binding sites can predict the outcome of newly diagnosed patients with gliomas. The predicative power of PET will be compared ...	{ "pile_set_name": "NIH ExPorter" }
We have recently identified and partially characterized a peptidase from human postmortem cerebral cortex that is highly active toward luteinizing hormone-releasing hormone (LH-RH) and probably other neuropeptides including angiotensin II, bradykinin, and neurotensin, but not somatostatin. We propose in this applicatio...	{ "pile_set_name": "NIH ExPorter" }
The use of neoadjuvant chemotherapy prior to resection or radiation therapy has contributed to dramatic improvement in survival of patients with pediatric malignancies. Precise clinical and radiologic methods of evaluating the primary lesion at diagnosis and assessing response to chemotherapy are necessary to select ap...	{ "pile_set_name": "NIH ExPorter" }
DESCRIPTION (Adapted from applicant's abstract and specific aims): The results from a large number of different experiments with SP-A and SP-D (lung collectins) in vitro suggest these two related proteins participate in at least two major physiologic processes: first, the regulation of lung surfactant homeostasis; and ...	{ "pile_set_name": "NIH ExPorter" }
The overall goal of Project 4 is to detemine how diabetes affects cardiac progenitor cell (CPC)-mediated myocardial repair after infarction and how CPC therapy could be optimized for the diabetic heart. Although stem cell therapy with CPCs offers new hope for the treatment of heart failure, the efficacy of stem cell th...	{ "pile_set_name": "NIH ExPorter" }
The goals of the research project are to devise a stereo- and regiospecific synthesis of chemically stable, cyclobutanone analogs of penicillins for testing as inhibitors of penicillinase as antibiotics, as inducers of penicillinase as antigens toward heterogeneous penicillin induced antibodies and as probes (i.e. iodo...	{ "pile_set_name": "NIH ExPorter" }
Mycobacterim tuberculosis infects approximately2 billion people, of whom greater than 2 million will die each year of tuberculosis.With the emergence of multidrug resistant strains and the growingHIV epidemic, the global problemof tuberculosisis worsening.In the last several years the role of the innate arm of the immu...	{ "pile_set_name": "NIH ExPorter" }
There is little research on predictors of patient satisfaction with health care for the 19 million Americans who are diagnosed with major depression and no research on whether these predictors differ by gender for this group. Patient satisfaction is thought to be a key quality of care indicators and is a central health...	{ "pile_set_name": "NIH ExPorter" }
The Cell, Molecular, and Genetics (CMG) Training Program at the University of California, San Diego is currently in its 29th year. This program is a cornerstone of the Ph.D. training effort in the biological sciences at UCSD, as it supports the very best graduate students from the Biology-Salk and Chemistry-Biochemistr...	{ "pile_set_name": "NIH ExPorter" }
The preovulatory LH surge stimulates an increase in ovarian matrix metalloproteinases (MMPs) and their associated inhibitors, the TIMPs, (collectively referred to as the MMP system) prior to follicular rupture in many species. The paramount role of the MMP system in ovulation is forthcoming from numerous experiments wh...	{ "pile_set_name": "NIH ExPorter" }
PROJECT SUMMARY/ABSTRACT: High-need, high-cost patients (HNHC) often experience poor coordination of care, a key driver of increased cost and utilization. Healthcare organizations and policymakers are investing in care coordination mechanisms that combine health information exchange with individualized care plans to fi...	{ "pile_set_name": "NIH ExPorter" }
Cytomegalovirus (CMV) infections following renal transplantation are extremely common, occurring in 60-86% of patients studied. This proposal seeks: (1) to establish more firmly the relationship between CMV and hepatic function abnormalities occuring in the post-transplant period and to determine the spectrum and natur...	{ "pile_set_name": "NIH ExPorter" }
The attainment of adequate self-regulation represents a critical developmental milestone that has significant implications for children's social-emotional wellbeing. Prior work has noted the importance of parenting for children's early developing self-regulatory skills, particularly at times in life, such as infancy an...	{ "pile_set_name": "NIH ExPorter" }
PROJECT SUMMARY The objective of the Stanford Research in Anesthesia Training Program (ReAP) is to train leaders in academic anesthesia. We recognize that in order to accomplish this goal, substantial training beyond an MD or PhD is required. ReAP provides the guidance, training, and mentoring critical for the successf...	{ "pile_set_name": "NIH ExPorter" }
Simvastatin, like lovastatin is converted to active metabolites by cytochrome P450 3A4 (CYP3A4). We have shown that lovastatin is susceptible to interactions with a commonly used calcium antagonist, diltiazem, that is known to have the capacity to block CYP3A4. Verapamil can similarly block this enzyme. The current stu...	{ "pile_set_name": "NIH ExPorter" }
The goal of the project is to study the electronic spectroscopy of porphyrins and related molecules such as phthalocyanines using a supersonic expansion to internally cool the molecules and to, thus, greatly simplify the spectra. We are interested in studying both the electronic and vibrational structure of these molec...	{ "pile_set_name": "NIH ExPorter" }
Project Summary Malaria that results from Plasmodium falciparum is among the most globally devastating human diseases. The principle vector of malaria, mosquitoes of the Anopheles gambiae species complex, are thus central targets for controlling the human health burden of Plasmodium. For nearly two decades, there have ...	{ "pile_set_name": "NIH ExPorter" }
Cognitive control and executive function are similar terms used to describe our ability to direct thought and action based on our goals and intentions, rather than being driven automatically by the world around us. Current theories of cognitive control propose that the prefrontal cortex (PFC) is a brain region that is ...	{ "pile_set_name": "NIH ExPorter" }
In many cases naturally occurring animal models of human genetic disorders, especially those affecting the nervous system, have not been described. In those instances where the gene defect has been identified, the introduction of mutant DNA into the germ line of mice can provide a unique opportunity to generate mice ha...	{ "pile_set_name": "NIH ExPorter" }
This project is a collaboration between Massachusetts General Hospital-Harvard Medical School and the International Centre for Diarrheal Disease Research in Bangladesh (ICDDR,B), focused on defining protective immunity to V. cholerae infection and developing an improved cholera vaccine. The central hypothesis of this p...	{ "pile_set_name": "NIH ExPorter" }
During this fiscal year, Dr. Bailey-Wilson has been collaborating with Drs. Trent and Carpten of the Cancer Research Branch and Drs. Cristina Leske, Barbara Nemesure and Anselm Hennis of State University of New York at Stony Brook on the planning phases of a proposed study of the genetic epidemiology of prostate cancer...	{ "pile_set_name": "NIH ExPorter" }
Cell cycle controls are organized into a loop, so that cycles may occur over and over again. These controls are of several kinds: transcriptional controls, proteolytic controls, protein kinase controls, etc. The development of microarray technology has now made it far easier and more efficient to investigate all kinds ...	{ "pile_set_name": "NIH ExPorter" }
Project Summary/Abstract for Phases I and II The purpose of this fast-track SBIR project entitled Paragraph and Essay Writing Instruction for Struggling Secondary Writers is to develop and evaluate the effectiveness of a total of four interactive multimedia (IM) software programs to be used to teach complex writing ski...	{ "pile_set_name": "NIH ExPorter" }
Biomedical scientists require ever improving tools to face the complex challenge of understanding the intricacies of protein regulation and its relationship to disease states. Recent research in the field of protein biochemistry has revealed that in many cases oxidative chemical modifications to protein molecules actua...	{ "pile_set_name": "NIH ExPorter" }
Despite the use of effective antibiotics in combination with cardiopulmonary support, the mortality rate from sepsis and septic shock for the last three decades has remained high (29%). Furthermore, the incidence of sepsis appears to be increasing. Lung infection or pneumonia is the most common cause of sepsis in patie...	{ "pile_set_name": "NIH ExPorter" }
The challenge of eliminating racial and ethnic health disparities requires expanding research beyond the biomedical model since many of the determinants of racial/ethnic health disparities differ from the factors that lead to an overall population decline in disease rates. We think that many of the determinants of raci...	{ "pile_set_name": "NIH ExPorter" }
(1) Clinical applications arising from stem cell and regeneration research will require an understanding not only of de novo tissue synthesis but also of the patterning mechanisms regulating blastema morphology. This project seeks to elucidate the regulatory networks controlled by biophysical epigenetic changes which o...	{ "pile_set_name": "NIH ExPorter" }
The long-term goal of this research is to understand the roles of of this research is to understand the roles of neuroendocrine homeostasis. CRF is the major integrator of these processes. Deviation of major integrator of these processes. Deviation of its regulation is its biological activity by binding two classes of ...	{ "pile_set_name": "NIH ExPorter" }
Mitochondrial dysfunction has been identified as one of the key players in Parkinson's disease (PD) pathogenesis. While the etiology is unknown in most cases, the development of progressive parkinsonian symptoms has been shown in patients following exposure to various environmental and occupational toxins. Numerous stu...	{ "pile_set_name": "NIH ExPorter" }
Gulf War Veterans Illness (GWVI) is a constellation of symptoms reported by Gulf War Veterans shortly after their return from deployment in 1991. Clinical diagnostic criteria for GWVI are based on chronic multisystem illness (CMI) criteria, which are based on statistical symptom cluster analysis resulting in three cate...	{ "pile_set_name": "NIH ExPorter" }
Duchenne muscular dystrophy (DMD) is a severe muscle wasting disease and the most prevalent inherited muscle disorder worldwide. It is caused by a mutation in the dystrophin gene, which normally encodes an important structural and signaling protein located at the muscle membrane. In DMD, the dystrophin protein is absen...	{ "pile_set_name": "NIH ExPorter" }
This application, entitled ?Student Transformative Experiences to Progress Underrepresented Professionals? (STEP-UP) for cancer prevention, is a multidisciplinary initiative led by the Cancer Prevention and Control and Health Disparities Programs' faculty at the University of Arizona Comprehensive Cancer Center. It is ...	{ "pile_set_name": "NIH ExPorter" }
Project Summary Progress in elucidating the role of the environment in child development and disability has been slow and incremental. Nearly all studies have examined relatively small populations of children; considered only one parameter at a time; had little power to examine interactions among chemical, social, and ...	{ "pile_set_name": "NIH ExPorter" }
Chronic inflammatory reactions in the brain, has been implicated to play a role in age-related neurodegenerative disorder's, such as Alzheimer's disease (AD). In AD, glial cells in the brain are alerted by the innate immune receptors on the glial cell surface following A[unreadable] deposition, resulting in activation,...	{ "pile_set_name": "NIH ExPorter" }
Project Summary/Abstract?Resource Component The objective of the Caenorhabditis Genetics Center (CGC) Resource Component is to promote research on the small metazoan Caenorhabditis elegans by curating important, genetically characterized nematode stocks and distributing them upon request to researchers and science educ...	{ "pile_set_name": "NIH ExPorter" }
The objective of the Clinical Research Skills Development Core is to develop skilled, productive, and independent translational and clinical investigators in vascular disease. Our specific aim is to train young investigators in designing, performing, analyzing and interpreting translational and clinical research to pre...	{ "pile_set_name": "NIH ExPorter" }
There is a widely held view that with advancing age efferent sympathetic nervous system (SNS) activity becomes elevated at rest and that the magnitude of the SNS response is increased during acute "stress". However, the experimental basis for this concept is rather weak because the data in both humans and animals have ...	{ "pile_set_name": "NIH ExPorter" }
Drosophila is one of a handful of model organisms used extensively in biomedical research. Importantly 60% of human disease genes are conserved in the fly. Genetic analysis in Drosophila has focused primarily on a whole organism approach but cell lines have also been at the forefront of research because of their utilit...	{ "pile_set_name": "NIH ExPorter" }
The cause(s) of neuropsychiatric systemic lupus erythematosus (NPSLE) remains an enigma. Although numerous reports of associations between specific autoantibodies and CNS manifestations have been published, serum levels of none of these autoantibodies has consistently shown a high degree of sensitivity and specificity ...	{ "pile_set_name": "NIH ExPorter" }
The maintenance of genomic integrity following DNA damage depends on the coordination of the DNA repair system and cell cycle checkpoint controls. Increasing evidence suggests that several tumor suppressors, including p53 and BRCA1, participate in these processes. Chk2, a DNA damage-activated protein kinase, regulates ...	{ "pile_set_name": "NIH ExPorter" }

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