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As an endpoint for many different types of cardiovascular disease, heart failure (HF) is a leading cause of mortality and morbidity in the U.S. Though some patients with HF have intact systolic function, virtually all patients with HF have abnormal diastolic function and an impaired ability to increase cardiac performa...	{ "pile_set_name": "NIH ExPorter" }
This application embodies support for three research programs of the Radiation Therapy Center plus limited support for the core program. The largest program deals with the development of radiopharmaceuticals for tumor and organ delineation. Second is a project dealing with the effect of radiation on carcinoembryonic an...	{ "pile_set_name": "NIH ExPorter" }
Th long-term goal of this research is to determine the three-dimensional structures of M-components. The source of the immunoglobulins and immunoglobulin fragments, whose crystal structures will be determined by X-ray diffracton, will be patients with monoclonal gammopathies. Most often these will be malignancies invol...	{ "pile_set_name": "NIH ExPorter" }
Post-absorptive changes of the plasma amino acids reflect the adequacy of the balance of the dietary amino acids. Previous studies conducted in our laboratory utilizing man or dogs as test subjects have been successful in developing an in vivo plasma amino acid (PAA) ratio procedure to assess the ideal intake of dietar...	{ "pile_set_name": "NIH ExPorter" }
The objective of this project is to determine the effect that the neuropeptide fragment ACTH 4-10 has upon the cognitive abilities of young and elderly individuals. This drug has been suggested to facilitate the efficiency of a number of mental operations including arousal, selective attention, and memory retrieval. We...	{ "pile_set_name": "NIH ExPorter" }
The goal of this project is to cross-reference the functional information known about genes actively under study in model organisms with genetic maps of the human and mouse genomes. The public database of Expressed Sequence Tags (dbEST) will serve as the source of novel human transcribed sequences that will be searched...	{ "pile_set_name": "NIH ExPorter" }
Medicare payments to oncologists for chemotherapeutic agents have been a source of considerable controversy for several years. The Medicare Modernization Act (MMA) changed reimbursement methods, effectively reducing the markups oncologists receive, especially for expensive agents. In this work we propose a regression d...	{ "pile_set_name": "NIH ExPorter" }
Project Summary Biomedical research increasingly involves examination of huge data sets. Introduction of new high- throughput sequencing technologies has led to production of new genome sequence for dozens of plants and animals and prompted major efforts to sequence individual human genomes. To take full advantage of t...	{ "pile_set_name": "NIH ExPorter" }
The intent of this application is to document the ability of Wills Eye Hospital's Glaucoma Service to participate as an effective and productive clinical center in the proposed multicenter clinical trial, entitled "Collaborative Initial Glaucoma Treatment Study" (CIGTS). This study's purpose is to evaluate whether init...	{ "pile_set_name": "NIH ExPorter" }
The quality of healthcare in the United States is inadequate and inequitable. There is a wide gap between the care people should receive and the care they do receive. Although much of the evidence for substandard quality comes from clinical care for adults, the limited data on children suggest that the quality of their...	{ "pile_set_name": "NIH ExPorter" }
Isozymes of heme oxygenase (HO) convert heme to biliverdin and provide the dominant heme-degradative mechanisms in tissues. HO-1 is the inducible, while HO-2 is the constitutive, isoform; HO-3 possesses trivial heme-degrading activity. The study of HO attracts considerable interest because of the recognized protective ...	{ "pile_set_name": "NIH ExPorter" }
Our long-term goal is to understand the molecular mechanism(s) that regulate(s) cytokinesis in mammalian cells, and to use this knowledge to develop novel cancer therapeutic strategies. Dysfunctional regulation of cytokinesis can lead to uncontrolled cell proliferation, a key characteristic of cancer. The integrity of ...	{ "pile_set_name": "NIH ExPorter" }
This application is directed towards understanding the mechanisms involved in pathogenesis of Barth syndrome, a rare X-linked mitochondrial disorder, caused by mutations in the tafazzin (taz) gene and characterized by dilated cardiomyopathy, skeletal myopathy, chronic fatigue, exercise intolerance, cyclic neutropenia a...	{ "pile_set_name": "NIH ExPorter" }
Influenza A and B viruses cause a highly contagious respiratory disease in humans. Influenza B viruses infect only humans, whereas influenza A viruses infect many avian and mammalian species. Influenza A viruses are responsible for the periodic wide-spread pandemics that result in high mortality rates. The 1918 pandemi...	{ "pile_set_name": "NIH ExPorter" }
The long-term goal of the proposed research is to understand molecular characteristics of ion movement through transmembrane channels. This goal will be pursued through studies on voltage-dependent sodium channels that are incorporated into planar lipid bilayers of defined composition. Ion permeation, pharmacological m...	{ "pile_set_name": "NIH ExPorter" }
This proposal aims to genetically determine the involvement of excess N-methyl-D-aspartate receptor (NMDAR) activity in the pathogenesis of early cognitive deficits of Down syndrome. Oligomeric Ap peptides are known to be generated very early in Down syndrome because of the extra copy of the APP (amyloid precursor prot...	{ "pile_set_name": "NIH ExPorter" }
DESCRIPTION (Applicant's Description): Under conditions of glaucoma, the cells of the retina begin to die, leading to progressive vision loss. This cell death may be due to a pressure-induced, excessive release of the neurotransmitter glutamate. While glutamate is a neurotransmitter normally used by retinal neurons, wh...	{ "pile_set_name": "NIH ExPorter" }
This proposal represents the second competing renewal of Vanderbilt's GI SPORE. This SPORE continues to focus on colorectal cancer, the second leading cause of cancer deaths in the US, where it affects more men and women than all other gastrointestinal malignancies combined. Over the last four years, Vanderbilt's GI SP...	{ "pile_set_name": "NIH ExPorter" }
The proposed demonstration project will test the effectiveness of a new, intensive multiphasic intervention model for chronically homeless veterans with alcohol and/ or drug problems. The proposed Case Managed Residential Care (CMRC) program will provide five days of intensive hospital "detox" followed by a graduated s...	{ "pile_set_name": "NIH ExPorter" }
With an estimated total cost of $90 billion ($12.5 Billion for medical care alone) and an overall prevalence of about 6%, diabetes has an impressive impact on the health care system. Between 90 and 95% of all diabetes cases consist of type 2 diabetes. the prevalence of type 2 diabetes among African-American women is pa...	{ "pile_set_name": "NIH ExPorter" }
The Scientific Core exists to facilitate the scientific projects within the program. The services, materials and reagents provided by the Scientific Core are purified proteins from natural and recombinant sources and infectious prions, synthetic peptides, DNA sequencing, PrP antibodies, transgenic mouse screening and a...	{ "pile_set_name": "NIH ExPorter" }
N-(4-(5-Nitro-2-furyl)-2-thiazolyl) formamide (FANFT) is a potent and highly specific carcinogen for the bladder of rat and provides a potential model for the study of human bladder cancer. The metabolism of FANFT may include deformylation, ring hydroxylation and nitroreduction. Its activation may involve the formation...	{ "pile_set_name": "NIH ExPorter" }
The mechanism or mechanisms by which the local blood flow is regulated according to the needs of the tissues remains uncertain. Metabolic, nervous, myogenic, and humoral factors may all be involved. An understanding of this control system is essential to rational treatment and prevention of many diseases. We intend to ...	{ "pile_set_name": "NIH ExPorter" }
Pollen is a ubiquitous allergen that affects a large population with allergic diseases. However, the mechanisms leading to resolution of pollen allergen-induced inflammation remain poorly understood, a knowledge gap preventing us from developing new targeted therapies to cure allergic diseases. We have recently uncover...	{ "pile_set_name": "NIH ExPorter" }
The Aging Research Center Laboratory Animal Core will operate as a shared resource, to facilitate and coordinate animal model studies for all five projects in this proposal. This core will build upon existing colonies from two different project members (Granholm and Rohrer) to develop disease-free, carefully phenotyped...	{ "pile_set_name": "NIH ExPorter" }
This project is designed to study local and systemic, humoral and cellular immunological responses in the lung of the rabbit following inhalation of antigen. Immunogenic requirements for hypersensitivity lung disease will be investigated as will immmunologic accompaniments of disease and of defense. Antigen-specific an...	{ "pile_set_name": "NIH ExPorter" }
Dehydration is a frequent cause of morbidity and mortality in the elderly. Identifying at risk individuals and maintaining adequate fluid balance is an essential component of health care in aging population. Currently, there is no effective tool available to measure hydration status and distinguish those at risk. The r...	{ "pile_set_name": "NIH ExPorter" }
Malaria is one of the most widespread infectious diseases of man and threatens almost half the world's population. Currently, there are an estimated 350+ million acute cases worldwide each year and approximately (sic) 1-2 million infants and young children die in Africa alone because of the disease. Traditional methods...	{ "pile_set_name": "NIH ExPorter" }
Nira Pollock, MD, PhD, is currently an instructor of medicine and infectious diseases (ID) at Beth Israel Deaconess Medical Center (BIDMC). The candidate's long-term goal is to develop an independent patient-oriented research career focused on the development and evaluation of new diagnostic tests for infectious diseas...	{ "pile_set_name": "NIH ExPorter" }
It has been proposed that the basal ganglia and the supplementary motor area (SMA), to which much of the output of motor areas of the basal ganglia is directed, play special roles in the control of movements that are based on internally stored information. It also has been proposed that information from SMA and the pos...	{ "pile_set_name": "NIH ExPorter" }
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which...	{ "pile_set_name": "NIH ExPorter" }
Use of the amphetamine MDMA (ecstasy, 3, 4-methylenedioxymethamphetamine) can result in life- threatening medical complications including fatal hyperthermia and cardiac arrhythmias. These complications result in part from simultaneous activation of the sympathetic nervous system, the hypothalamic-pituitary- adrenal axi...	{ "pile_set_name": "NIH ExPorter" }
We request partial support for the 2014 Lipoprotein Metabolism Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) to be held at Waterville Valley Resort, NH on June 16-20, 2014. The Co- Chairs, Drs. Robert Farese, Jr. and Joachim Herz, in consultation with past chairs, the 2016 vice chairs, and leaders ...	{ "pile_set_name": "NIH ExPorter" }
Over the past decade, investigations using genetically-engineered mice have led to new insights into the genetic control of embryonic vascular development, which has also had a major impact on our understanding of neovascularization in many human diseases including cancer, atherosclerosis and diabetes. Micro-imaging me...	{ "pile_set_name": "NIH ExPorter" }
Genalyte will demonstrate the feasibility of our bio-sensing instrument platform for rapid sensitive high- throughput and low cost multiplexed panels to identify and monitor immune status for Type 1 Diabetes (T1D) auto-antibodies. The key to this capability is a proprietary label-free sensor based on silicon photonics ...	{ "pile_set_name": "NIH ExPorter" }
High resolution images of molecular oxygenation images can provide crucial guides to the delivery and monitoring of cancer therapy. EPR imaging (EPRI) of oxygen provides a unique combination of spatial resolution, oxygen resolution, and uniform sensitivity with depth in tissue. This Center focuses on the optimization o...	{ "pile_set_name": "NIH ExPorter" }
This proposal is for Phase I, or, the "Treatment of Mild Hypertension Study" (TOMHS). Men and women with mild hypertension (DBP 90-99 mmHg) not on drugs, and DBP less than 95 mmHg on drugs, who are 45-69 years of age and free of evidence of end-organ damage related to their hypertension, will be recruited and randomize...	{ "pile_set_name": "NIH ExPorter" }
This proposal concerns two fundamental aspects of development: the creation of cell diversity and the directed movements of differentiating cells. The experimental organism is the simple eukaryote Dictyostelium discoideum. During the developmental phase of its life cycle, two precursor cell types diverge from undiffere...	{ "pile_set_name": "NIH ExPorter" }
DMA topoisomerase I (Topi) plays important roles in DMAreplication, transcription and recombination and is also the target of camptothecin (CRT), FDA approved analogs of which are effective new agents in the treatment of human cancers. CRT poisons Topi by reversibly stabilizing a covalent enzyme-DNA complex. During S-p...	{ "pile_set_name": "NIH ExPorter" }
Project Summary: Previous research has shown that abnormal electrical conduction in the infarct border zone is important in the pathogenesis of ventricular arrhythmias in the setting of coronary artery disease. These abnormalities are due to remodeling in tissue architecture (fibrosis) and of connexins in gap junctions...	{ "pile_set_name": "NIH ExPorter" }
Chronic renal disease (CKD) is closely related with poor cardiovascular outcomes. Our recent experimental data indicate that Na/K-ATPase reduction may be related with renal insufficiency-induced cardiac dysfunction. First, we have observed that 5/6th partial nephrectomy (PNx) induces a time-dependent decrease of Na/K-A...	{ "pile_set_name": "NIH ExPorter" }
Hunter College of the City University of New York is a large, urban, diverse campus with over 50% minority students. The Hunter SCORE program supports research in 16 of the 50 research labs in the School of Arts and Sciences, which in 2002 published 145 peer-reviewed papers based on research of 35 post-docs, 150 PhD st...	{ "pile_set_name": "NIH ExPorter" }
A Bridges to the Doctorate program between the two major Hispanic Serving Institutions (HSI) in California's Central Valley is proposed. This program will assist under-represented minority (URM) students from the California State University, Fresno with completing a Master's program in the biomedical sciences before co...	{ "pile_set_name": "NIH ExPorter" }
PROJECT SUMMARY This application seeks partial support for the upcoming Federation of American Societies of Experimental Biology (FASEB) conference entitled, ?Skeletal Muscle Satellite Cells and Regeneration?, to be held July 24-29, 2016 in Keystone, CO. This will be the 9th meeting on satellite cells and the 8th spons...	{ "pile_set_name": "NIH ExPorter" }
Project Summary/Abstract________________________ Induced pluripotent stem cells (iPSCs) hold great promise in the areas of disease modeling and regenerative medicine and as a result have unique commercial potential. There are currently more than 300 ongoing clinical trials in stem cell therapies including the first-in-...	{ "pile_set_name": "NIH ExPorter" }
The objective of this study is to test the effectiveness of an evidence-based, Spanish language prescription drug (Rx) labeling strategy to improve patient understanding and use. The primary aims of this study are to: 1) Test the efficacy of enhanced Spanish Rx labeling (container label, leaflet) to improve Spanish-spe...	{ "pile_set_name": "NIH ExPorter" }
A common feature of abused drugs such as heroin and cocaine is that their use by humans tends to become habit forming. Similar behavior has also been observed in rats and mice, who will self-administer opiates or cocaine repeatedly if given the opportunity. The repeated self- administration of these drugs is thought to...	{ "pile_set_name": "NIH ExPorter" }
The goal of this project is to identify the genes (and their respective sequence variants) that play a role in conferring susceptibility to obesity in humans. Knowledge of the nature of these genes, and of the biological mechanism(s) of their actions, would contribute enormously to diagnosis, treatment and prevention o...	{ "pile_set_name": "NIH ExPorter" }
One major long term objective is to develop and have available for extensive use, a preschool cognitive screening test which will more effectively identify four and five - year - old children who, absent any educational intervention, will experience academic failure, develop emotional and/or motivational disturbances, ...	{ "pile_set_name": "NIH ExPorter" }
The genome of dengue virus and other members of the flavivirus group consists of a positive strand 42S RNA 10-12,000 bases in length. A 42S mRNA produced in infected cells codes for the three structural proteins V1, V2, and V3 which are also designated the envelope, core and matrix proteins, respectively. The remaining...	{ "pile_set_name": "NIH ExPorter" }
FepA, an 81 kD protein of gram-negative bacteria, transports iron across the outer membrane in a manner that requires a number of accessory proteins in the bacterial cell envelope. For this reason, it is desirable to study protein dynamics in the intact cell. Spin-label binding sites were introduced into the cell-surfa...	{ "pile_set_name": "NIH ExPorter" }
Specific areas of research include: Coupled transcription and translation in vitro with negative strand viruses; transcriptional mapping of (-)RNA viruses by UV survival curve analysis; mechanism of action of interferon --- role of oligonucleotide inhibitor and of dsRNA and ATP activated endoribonucleasease; regulation...	{ "pile_set_name": "NIH ExPorter" }
IDENTIFY BIOCHEMICAL INDICATORS FOR TOXICITY	{ "pile_set_name": "NIH ExPorter" }
Our aim is to investigate the role of nociceptive neurons in the peripheral and central nervous system in mediating cutaneous pain, itch and hyperalgesia. Peripheral neural mechanisms of chemogenic pain and itch will be studied by obtaining psychophysical measures in humans of the threshold, magnitude and duration of s...	{ "pile_set_name": "NIH ExPorter" }
PROJECT SUMMARY/ABSTRACT US healthcare policy, practice and research leaders have expressed increased interest in the vision of the ?learning healthcare system,? a set of organizational goals and arrangements in which healthcare delivery processes are continuously studied and improved, largely by applying formal resear...	{ "pile_set_name": "NIH ExPorter" }
This study will focus on the fundamental question of whether reactive metabolites of dopamine, may be contributing to the pathogenesis of neurodegenerative disorders such as Parkinson's disease. Dopamine has been shown to be toxic to cells both in vitro and in vivo. However, the exact mechanism associated with the toxi...	{ "pile_set_name": "NIH ExPorter" }
Objectives are 1) to inventory the perceived and measurable effects of Federal health grants on the administrative procedures and program priorities of local recipients, public and private; and 2) to assess the significance of these findings for grants policy, comprehensive planning, and regulation of health providers....	{ "pile_set_name": "NIH ExPorter" }
The Comprehensive Sickle Cell Center at The Children's Hospital of Philadelphia (CHOP) is in its fourth year of operation. In the past four years, we have made much progress in all the major components of the Center. Although much has been learned about sickle cell disease at all levels, effective therapy which takes a...	{ "pile_set_name": "NIH ExPorter" }
The overall goal of this proposal is to test whether targeting individual cell cycle proteins represents a highly selective therapeutic strategy in different types of human breast cancer. The proliferation of mammalian cells is driven by the core cell cycle machinery operating in cell nucleus. The key components of thi...	{ "pile_set_name": "NIH ExPorter" }
Rationale and Relevance: Infectious diseases still account for significant morbidity and mortality in the developing world. Vaccines are one of the most cost effective advances in medical science, and if appropriately used, are potent instruments in the control of infectious diseases. Successful vaccine development req...	{ "pile_set_name": "NIH ExPorter" }
During my career I have worked on several projects creating software (FASTLINK, CASPAR, rh_tsp_map,[unreadable] PedHunter, etc.) and a database (Anabaptist Genealogy database) for genetic studies.[unreadable] My association with this software and a past track record of effective collaboration[unreadable] with wet lab s...	{ "pile_set_name": "NIH ExPorter" }
The helical growth system of Bacillus subtilis is being investigated. An examination of over 50 films illustrating the manner in which helical macrofibers are built suggests that the folding cycle and its associated physical movements are a direct reflection of the individual cell cycles taking place within the macrofi...	{ "pile_set_name": "NIH ExPorter" }
Proper brain function requires the establishment and maintenance of effective neural circuits. Neural circuit development entails axon guidance, synaptic target selection, synapse formation, and synaptic growth and remodeling in response to developmental and environmental cues. Large protein complexes in both the pre- ...	{ "pile_set_name": "NIH ExPorter" }
The primary purpose of this program is to develop services for alcoholics and their families. The goal is to induce and maintain sobriety for the alcoholic and provide comprehensive services to him and his family through effective relationship with other ongoing programs such as health services, vocational rehabilitati...	{ "pile_set_name": "NIH ExPorter" }
Grant Title:Whitaker-Dowling Pitt - Collaborative Biomedical Grant	{ "pile_set_name": "NIH ExPorter" }
The research proposed compares several methods of evaluating level of habitual physical activity (PA) and fitness in athletic and 100 nonathletic men and women age, 20 to 59. This research will determine the reliability and validity of a variety of evaluation tools for assessing PA and fitness. PA will be assessed repe...	{ "pile_set_name": "NIH ExPorter" }
Parkinson's disease is a devastating, universally fatal, incurable neurodegenerative disorder, which is debilitating and inflicts terrible suffering on the patient's mind and body. Human pluripotent cells, including embryonic stem cells, have been identified as a potential alternative cellular substrate for treatment, ...	{ "pile_set_name": "NIH ExPorter" }
Determine the relative efficacy of 3 treatment approaches to reduce myocardial ischemia in individuals with stable angina and documented coronary artery disease, ischemia on treadmill testing, and ischemia on ambulatory ECG (AECG) monitoring. Patients were randomized to angina-guided therapy, angina-guided plus AECG-gu...	{ "pile_set_name": "NIH ExPorter" }
Influenza B viruses have been represented in human populations in recent years by two divergent strains, B/Victoria/2/87-like and B/Yamagata/16/88- like viruses.Drift in the B/Yamagata-like viruses has been identified by a panel of ferret antisera during the past year and has raised the question of need for further alt...	{ "pile_set_name": "NIH ExPorter" }
This FIRST award proposal investigates alterations in intracellular signal transduction as molecular mechanisms in sepsis and endotoxemia. Gram- negative sepsis is a leading cause of death worldwide. Treatment remains supportive. New and more effective therapies will require defining the pathogenesis of sepsis at molec...	{ "pile_set_name": "NIH ExPorter" }
In this randomized, double-blinded multicenter trial, sponsored by ISIS Pharmaceuticals, a novel approach for the treatment of condyloma acuminata using an "antisense" compound (ISIS 2105) is being evaluated for safety and efficacy.	{ "pile_set_name": "NIH ExPorter" }
Clinical studies have shown that estrogen (E2) can ameliorate symptoms of mood disorders in women, including severe depression. The presence of symptoms may represent an abnormal response to normal hormonal changes, thereby implicating contextual factors in the brain in the etiology of these symptoms. Some of these fac...	{ "pile_set_name": "NIH ExPorter" }
Dietary restriction (DR) is defined as a 25-50% decrease in calorie intake without a decrease in essential nutrients. Such undernutrition without malnutrition 1) increases average and maximal survival times of rodents, 2)\prolongs aspects of normal organ function, and 3) delays the onset of several late life diseases. ...	{ "pile_set_name": "NIH ExPorter" }
DESCRIPTION (provided by applicant: Cholera is a waterborne diarrheal disease caused by Vibrio cholerae of serogroup O1 and O139. The serogroup O1 can be divided in two biotypes: classical and El Tor. The current and seventh cholera pandemic is characterized by the predominance of the El Tor biotype. Recently, hybrid V...	{ "pile_set_name": "NIH ExPorter" }
The overall aim of this study is to determine risk factors for the development of high intraocular pressure (IOP) and glaucoma visual field defects (GVFD). These factors include systemic hypertension, antihypertensive therapy, cardiovascular risk factors, family history, demographic and othe variables. Previous studies...	{ "pile_set_name": "NIH ExPorter" }
Brain corticotropin-releasing factor (CRF) systems play an essential role in coordinating stress-induced endocrine, autonomic, behavioral, and immune responses. In the amygdala, CRF peptide and receptors are located in nuclei implicated in fear and anxiety. Importantly, pathophysiology of CRF systems and the amygdala i...	{ "pile_set_name": "NIH ExPorter" }
Hearing loss is a leading public health concern, with about 17% of American adults reporting some degree of impairment. Of those, fewer than 20% seek help for their condition for a variety of reasons. To address this issue, the National Institue of Deafness and Other Communication Disorders (NIDCD) is seeking solutions...	{ "pile_set_name": "NIH ExPorter" }
Over 100 million Americans consider themselves to be regular drinkers, and approximately 20 percent of these individuals will eventually develop alcohol-related problems. Despite the staggering socio-economic cost of alcoholism, little is known about either the physiological factors the predispose an individual to this...	{ "pile_set_name": "NIH ExPorter" }
Nephrocalcin (NC) is a calcium-binding glycoprotein that has been isolated from human urine and human kidney tissue culture, and that inhibits growth of the calcium oxalate crystals in vitro. Molecular abnormalities have been found in NC isolated from the pooled urine of calcium stone formers, which decrease its affini...	{ "pile_set_name": "NIH ExPorter" }
A general understanding of the interaction of (monoclonal) antibodies with their homologous saccharides is important in order to a) gain an insight into the immunogenicity of oligo- and polysaccharides, and b) gain insights into the general nature of the interaction of proteins (including e.g. receptors, enzymes) with ...	{ "pile_set_name": "NIH ExPorter" }
[unreadable] [unreadable] Our mission is to make available human brain and other body parts specimens from neuropsychiatric diseases and disorders, and normal controls. The Human Brain and Spinal Fluid Resource Center (Bank), established since 1961 is a repository of blood, cerebrospinal fluid (CSF) and cryopreserved p...	{ "pile_set_name": "NIH ExPorter" }
The generation of energy in mammalian mitochondria is accomplished by a series of oligomeric complexes in the inner membrane. The synthesis and assembly of these complexes requires genetic information ;contained in both the nuclear and mitochondrial genomes. Limited information is available on the mechanism by which th...	{ "pile_set_name": "NIH ExPorter" }
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which...	{ "pile_set_name": "NIH ExPorter" }
Epstein-Barr virus (EBV) causes infectious mononucleosis in adolescents and malignant B lymphocyte proliferation in AIDS patients and patients undergoing immune suppression for organ transplantation. EBV is etiologically associated with African Burkitt's lymphoma and nasopharyngeal carcinoma. In vitro, EBV transformed,...	{ "pile_set_name": "NIH ExPorter" }
Infectious diseases remain a global threat to human health that significantly contributes to mortality and morbidity in developing and industrialized countries. While many can recall the fear of polio, now nearly eradicated, the presence of new diseases and reemerging diseases that strike individuals and populations ha...	{ "pile_set_name": "NIH ExPorter" }
This is a new project, just commencing. Extensive studies of Ewing's sarcoma and related round cell tumors of childhood have served to distinguish most from one another on the basis of positive reactivity with one or more antibodies. No antibody specific for Ewing's sarcoma, or restricted to a few tumors including Ewin...	{ "pile_set_name": "NIH ExPorter" }
A series of 22 Substance P analogs, characterized by elongation or shortening of the peptide chain or by replacement of some amino acids, will be synthesized and pharmacologically analyzed in order to elucidate the chemical and biological reactivity of Substance P, and to support and expedite the establishment of the c...	{ "pile_set_name": "NIH ExPorter" }
Project summary: Ants are social insects that can be developed as experimentally tractable organisms for probing the dynamic changes in the epigenetic programs that control an array of processes, including aging. Aging is a process of progressive decline in intrinsic physiological functions. There is a well-established...	{ "pile_set_name": "NIH ExPorter" }
The commonest gastrointestinal (Gl) carcinoids occur in the small intestine and appendix. Both are derived from the enterochromaffin (EC) cell, but their malignancy and propensity to metastasize vary widely. Small intestinal carcinoids (SICs) are aggressive and exhibit hepatic and lymph node (LN) metastasis; appendicea...	{ "pile_set_name": "NIH ExPorter" }
Cellular membranes are not simple barriers, and the appropriate membrane composition is essential to ensure proper function of the membrane. In fact, dysfunction as a result of altered membrane composition has been observed in a wide range of diseases including cancers, neurodegenerative and age-related diseases. The c...	{ "pile_set_name": "NIH ExPorter" }
In addition to examining in more detail the influence of antineoplastic agents upon the metabolism, distribution, and binding of drugs and their toxicity, the metabolic fate of selected antineoplastic agents will be studied. Carcinolytic agents will be employed as model substrates for the in vitro measurements of micro...	{ "pile_set_name": "NIH ExPorter" }
Better understanding of the etiologic roles of family history, prenatal environmental factors, and potential biologic mechanisms, such as epigenetic changes, in autism spectrum disorders (ASD) are research priorities identified in the Autism Coordinating Committee 2011 Strategic Plan for Autism Spectrum Disorder Resear...	{ "pile_set_name": "NIH ExPorter" }
The goal of our research is to identify and characterize the machinery involved in eukaryotic DNA replication. We focus on the isolation of the individual proteins and protein complexes required for DNA synthesis and define their role in this critical macromolecular process. All growing cells must duplicate their DNA a...	{ "pile_set_name": "NIH ExPorter" }
Case Western University's Begun Center for Violence Prevention Research and Education, Kent State University's Institute for the Study and Prevention of Violence, and the Partnership for a Safer Cleveland will collaborate to address youth violence prevention information dissemination and research through a joint effort...	{ "pile_set_name": "NIH ExPorter" }
The studies proposed in this application are designed to 1. determine whether the circadian rhythm of IOP reflects a circadian rhythm of aqueous formation, 2. explore the neural and humoral pathways which mediate regulation of this rhythm of IOP, and 3. identify biochemical mechanisms which underlie the local, ocular m...	{ "pile_set_name": "NIH ExPorter" }
Urinary tract infections (UTIs) result in considerable morbidity and health care costs. The most common cause is the Gram-negative bacteria, uropathogenic Escherichia coli (UPEC). Human infections are characterized by bacteriuria and the release of cytokines, exfoliated cells, and polymorphonuclear leukocytes (PMN) int...	{ "pile_set_name": "NIH ExPorter" }
This project involves developing imaging agents which will allow the asessment of dopaminergic and serotonergic activity in the brain non-invasively using positron emission tomography (PET). Short-lived positron emitting isotopes, 18F (t+=110 min.) and 11C (t+=20 min.), are introduced into amino acid analogs which are ...	{ "pile_set_name": "NIH ExPorter" }
Children with Attention Deficit/Hyperactivity Disorder (ADHD) are at risk for serious adverse developmental outcomes, including criminal behavior, depression, and suicidality. Parenting and parental psychopathology are robust predictors of long-term developmental outcomes in this population. For instance, early materna...	{ "pile_set_name": "NIH ExPorter" }
[unreadable] The purpose of this competing continuation is to continue our training program in the human behavioral pharmacology of drug dependence. Our decision to seek to continue this training program is driven by our training successes. For example, during the past ten years we have trained 14 pre-doctoral student ...	{ "pile_set_name": "NIH ExPorter" }
Angiotensin ll-infused rats exhibit increases in renal angiotensinogen (AGT) mRNA and protein, and this may be one mechanism by which low levels of circulating angiotensin II induce progressive hypertension. Using an interesting transgenic mouse model in which human AGT is expressed only in the kidney, it is possible t...	{ "pile_set_name": "NIH ExPorter" }

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