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My laboratory investigates the properties of natural and chemically modified nucleic acids. Working at the interface of cell biology and nucleic acid chemistry we have modified cellular activities including transcription, translation, allele-selectie inhibition of protein expression, splicing, and telomerase-mediated e...	{ "pile_set_name": "NIH ExPorter" }
Project Summary/Abstract The purpose of this study is to advance the science of recovery from alcohol problems through development of a standardized survey measure of recovery capital. Recovery capital is a theoretical construct that encompasses the ways in which physical, social, human, and cultural resources shape a ...	{ "pile_set_name": "NIH ExPorter" }
Bone mineral is basically calcium phosphate, and both elements (Ca and P) are required for bone acquisition. Typical Ca intakes in the U.S. are lower than current recommendations, and typical P intakes, higher. Thus attention has been focused mainly on increasing Ca intake, by supplementation and food fortification. Th...	{ "pile_set_name": "NIH ExPorter" }
The overall objective of this project is the identification and characterization of tumor-associated antigens of human colonic tumors. This will be initially investigated by using human colonic cancer xenografts established in unconditioned golden hamsters and in continuous propagation in these hosts. Of immediate inte...	{ "pile_set_name": "NIH ExPorter" }
Lung endothelium has historically been considered a homogeneous and metabolically inactive cell layer. However, we now know that lung endothelium is richly diverse in structure and function, and actively participates in normal vascular homeostasis, the response to lung injury, and vascular repair following injury. This...	{ "pile_set_name": "NIH ExPorter" }
This is a competing renewal application for the Pacific Northwest (PNW) Node, which joined the NIDA National Drug Abuse Treatment Clinical Trials Network (CTN) in January, 2001. Our primary aim is to continue our active support of the CTN's mission, to "improve the quality of drug abuse treatmentthroughout the country ...	{ "pile_set_name": "NIH ExPorter" }
This 5-year multi-center randomized trial will assess the effectiveness of Early Revascularization (ERV) using approved mechanical and surgical procedures (primarily PTCA and CABG) in reducing the current high in- hospital mortality rate from cardiogenic shock (CS) complicating acute myocardial infarction (MI). Approxi...	{ "pile_set_name": "NIH ExPorter" }
Elderly patients often face high-risk health care decisions about vascular disease, and informed decisions are needed to obtain the best results. Carotid revascularization, via surgical carotid endarterectomy or carotid artery stenting, is among the most frequently performed vascular procedures, and is widely recommend...	{ "pile_set_name": "NIH ExPorter" }
Multiple expression forms of the hS0S1 and GRF genes were detected in polyA+ mRNA Northerns from human adult and fetal tissues, including brain. placenta. pancreas. lung. kidney and skeletal muscle. Consistent with this variety of mRNA transcripts, in soluble fraction (5100) and in membrane (P100) of different human ti...	{ "pile_set_name": "NIH ExPorter" }
Fungi, especially those which live in symbiotic association with other organisms, are rich sources of small-molecule natural products representing novel structures and eliciting diverse biological responses, but to date they remain underexplored. The goal of this project is to generate molecular libraries derived from ...	{ "pile_set_name": "NIH ExPorter" }
The prion hypothesis poses a new paradigm for both infectivity and inheritance in which self- replicating alternate conformers of a normal, cellularly encoded protein specify new traits. In order for a protein to act in these roles, which have been historically limited to nucleic acids, a prion protein must traverse a ...	{ "pile_set_name": "NIH ExPorter" }
The Research Core will generate new knowledge on minority health and chronic disease, specifically cancer and cardiovascular disease, with emphasis on developing and testing interventions to reduce these disparities. The Core will combine oversight of two P60-supported full research projects with an innovative pilot pr...	{ "pile_set_name": "NIH ExPorter" }
The Chicago Center for Reproductive Research Molecular Technology Core is established to function as a common facility where specific technical services and expertise are available to all project investigators. The Core facility will ensure increased efficiency and functionality of each of the individual projects. The ...	{ "pile_set_name": "NIH ExPorter" }
In recent years, we have discovered that certain drugs (methylxanthines, phosphodiesterase inhibitors and selective A1 adenosine receptor antagonists) will induce plasticity in the respiratory pathways which results in recovery of the diaphragm after cervical spinal cord injury. Furthermore, we discovered that after ra...	{ "pile_set_name": "NIH ExPorter" }
Preliminary experiments on effects of microwave irradiation (1 mWatts/cm2) on barbiturate induction time and sleeping time in mice indicate the following interactions. Barbital and phenobarbital induction times were shortened by irradiating for 10 minutes immediately before intravenous administration of the barbiturate...	{ "pile_set_name": "NIH ExPorter" }
The several time-bound effects of prestimulation on the human startle reflex offer the possibility that different levels of neural processing may be distinguished and may elucidate the nature of changes occurring in early development. The first approach will be to determine the age at which effects ascribable to a shor...	{ "pile_set_name": "NIH ExPorter" }
Cardiac imaging has emerged as an important tool for assessing the diagnosis and prognosis of patients with coronary artery disease. The extent and severity of coronary arterial obstruction (provided by coronary arteriography), along with the degree of myocardial hypoperfusion (provided by perfusion tomography) and the...	{ "pile_set_name": "NIH ExPorter" }
Introduction: This is an interdisciplinary bioengineering project to develop and evaluate dynamic magnetic resonance imaging (MRI) techniques for the clinical management and surgical planning of pediatric patients suffering from deteriorating renal function. The long term goal is to replace the existing renal tests, wh...	{ "pile_set_name": "NIH ExPorter" }
Efficient muco-ciliary clearance is maintained by a multi-regulatory system complex. The prime objective of the proposed work is to elucidate the fundamental organization and behaviour characteristics of the regulatory system complex by a comprehensive approach. Further refinement of the model of muco-ciliary clearance...	{ "pile_set_name": "NIH ExPorter" }
With the development of rapid, accurate, high-throughput autoantibody and potentially HLA assay systems, we are rapidly achieving the ability to screen and detect pre-diabetic subjects in the general population. Intervention studies in the NOD mouse suggest that antigen specific therapy can be effective in preventing d...	{ "pile_set_name": "NIH ExPorter" }
The general objective of this project is to provide support and care for the use of transgenic, severely compromised immunodeficient (SClD), knockout, and specific pathogen free (SPF) mice at Stony Brook University (SBU). The Institution has both short-term and long-term goals to improve animal care and services for th...	{ "pile_set_name": "NIH ExPorter" }
It has been generally assumed that secretin is a physiological stimulant for pancreatic water and bicarbonate secretion. There is, however, no proof for this assumption. In fact, there is some recent evidence that it may be invalid. In order to qualify as physiologic stimulant, secretin has to be released after intake ...	{ "pile_set_name": "NIH ExPorter" }
The objective of this proposal is to understand how people perceive tactile patterns. The project will focus on the processing of tactile spatial patterns. Studies will be conducted comparing interactions between spatial patterns presented to the same location and to separate locations. Results from the psychophysical ...	{ "pile_set_name": "NIH ExPorter" }
Molecular dynamics simulations of oligopeptides in solution will be used to study the ways in which hydrogen bonds characteristic of protein secondary structure are made and broken. Structures considered will include 13-membered rings closed by a hydrogen bond (found in alpha-helices) and 10-membered rings (found in be...	{ "pile_set_name": "NIH ExPorter" }
Depression is among the most prevalent of all psychiatric disorders. Consistent with the NIH objectives of promoting discovery in the brain and behavioral sciences to fuel research on the causes of mental disorders and charting mental illness trajectories to determine when, where, and how to intervene, a critical publi...	{ "pile_set_name": "NIH ExPorter" }
The neuropharmacological basis for organochlorine-induced tremor and hyperexcitability was studied in rats. Both chlordecone and p,p'-DDT increased the release of brain norepinephrine and serotonin, while having marginal effects on dopamine; p,p'-DDT, but not chlordecone, was found to increase tissue levels of excitato...	{ "pile_set_name": "NIH ExPorter" }
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which...	{ "pile_set_name": "NIH ExPorter" }
The product that will result from this proposal is a nucleoside-modified mRNA encoding erythropoietin for treatment of red blood cell deficiency (anemia). In vitro transcribed mRNAs encoding physiologically important proteins have considerable potential for therapeutic applications. However, mRNA is naturally labile, i...	{ "pile_set_name": "NIH ExPorter" }
The selection and refinement of appropriate psychophysical methods for the separate measurement of the various aspects of taste perception is a primary and continuing concern of this project. Normal variation in taste perception with chronological age is assessed by procedures which quantify not only the taste detectio...	{ "pile_set_name": "NIH ExPorter" }
Eye-movement analysis software employing new algorithms has been successfully tested in Phase I for its ability to automatically quantify caloric, rotational, smooth pursuit and optokinetic tests in routine clinical use. In the Phase II project, some refinements in the basic algorithms suggested by results of the Phase...	{ "pile_set_name": "NIH ExPorter" }
The administrative shell has an organizational rather than a scientific focus. While the goals of the individual Cores are to serve the user base, the goal of the administrative shell is to serve the individual cores, overarching needs and the overall Research Core Center mission. The charge to the administrative shell...	{ "pile_set_name": "NIH ExPorter" }
This application is in response to a Request for Application (RFA-HD-10-018) to conduct community-linked studies to investigate the role of prenatal alcohol exposure in the risk for SIDS, stillbirth and FASD, and to determine how these different outcomes are inter-related, The proposed research will be conducted by the...	{ "pile_set_name": "NIH ExPorter" }
The current proposal recognizes that individuals do not operate in a vacuum but rather our lives are inextrica- bly intertwined with family, friends, and community. Taking a multilevel and ecologically valid approach, we plan to identify barriers and conduits to cervical cancer prevention, detection, and treatment amon...	{ "pile_set_name": "NIH ExPorter" }
The increased use of amphetamine-type stimulants (ATS), which refer to the group of stimulants including methamphetamine (MA) and amphetamine, has become a major global health problem in recent years. There is also an increasing concern about the high rate of the non-medical use of prescription stimulants among adolesc...	{ "pile_set_name": "NIH ExPorter" }
This grant is the major support of pre- and postdoctoral trainees in the Graduate Group of Nutrition. The program at UCD is unusual in many respects and a model for training in an applied science, such as Nutr. There are 30 faculty with basic and clinical emphases who are committed to mentorship and didactic training. ...	{ "pile_set_name": "NIH ExPorter" }
Cortical thickness cocaine dependence is one of the most difficult substance-use disorders to treat and currently has no FDA- approved interventions. While current pharmacological strategies modulate neurochemistry in a spatially- unbiased manner, the development of non-invasive brain stimulation strategies would enabl...	{ "pile_set_name": "NIH ExPorter" }
The debate regarding the reality of repressed and recovered memories of childhood sexual abuse (CSA) has occurred almost entirely uninformed by data on memory functioning in individuals reporting recovered memories of CSA. The purpose of the proposed research, therefore, is to test hypotheses about memory in women who ...	{ "pile_set_name": "NIH ExPorter" }
Our established gonadotroph cell lines will be used to better define the regulatory mechanisms for the secretion of gonadotrophins (FSH and LH). We plan to examine direct effects of a number of agents such as neurohumoral substances and steroids which are known to influence gonadotrophin-secretion using our established...	{ "pile_set_name": "NIH ExPorter" }
The overall objectives of the proposed project is to investigate and clarify the pharmacological and physiological interrelationships between calcium and the secretion and effects of calcemic and gastrointestinal (GI) hormones. The goal is to relate the findings to calcium homeostasis and gastrointestinal function in h...	{ "pile_set_name": "NIH ExPorter" }
In recent years, diminished governmental support, dwindling faculty numbers and the need to educate greater numbers of students in the face of declining public health funding have made it increasingly difficult for the University of Zimbabwe College of Health Sciences (UZCHS) to meet the healthcare training needs of Zi...	{ "pile_set_name": "NIH ExPorter" }
Onychomycoses are fungal infections of both the fingernails and the toenails accounting for up to 50% of all the nail disorders. They are currently treated by oral and topical administration of the antifungal drugs. Oral antifungal therapy is generally associated with serious adverse effects independent of or associate...	{ "pile_set_name": "NIH ExPorter" }
The overall objective of the proposed activity is to acquire, by purchase or otherwise, death index records from the 56 U.S. registration areas for compilation into a consolidated death index covering some period of time prior to 1979. The consolidated file will be for the direct use and benefit of the government and w...	{ "pile_set_name": "NIH ExPorter" }
Anorexia Nervosa (AN) is a serious disorder associated with significant psychiatric and medical morbidity and mortality and high treatment costs due to the use of intensive treatment. Evidence suggests that FBT for adolescent AN is an effective outpatient treatment both at the end of treatment and 4-5 year follow-up. U...	{ "pile_set_name": "NIH ExPorter" }
The long term objectives of this proposal are to elucidate the exact sequence of biochemical events that are involved in the priming and stimulation of superoxide (02-) production by neutrophils. Superoxide is a key component of the oxygen-dependent antimicrobial mechanisms of these cells which provide a major defense ...	{ "pile_set_name": "NIH ExPorter" }
Many cases of sensorineural hearing loss (SNHL) likely are caused by interruption of cochlear blood flow (CBF). Disruption of the internal auditory artery during surgical procedures to remove acoustic neuromas (ANs) probab'y account for many cases of postoperative deafness. Also, many cases of clinical SNHL, such as su...	{ "pile_set_name": "NIH ExPorter" }
A series of experiments have been proposed to elucidate the mechanisms of two enzymes, dopamine Beta-monooxygenase and peptidylglycine alpha-hydroxylating monooxygenase. These enzymes play an important role in the synthesis and regulation of hormones. Many aspects in the mechanisms of these enzymes are still unresolved...	{ "pile_set_name": "NIH ExPorter" }
The long-range goal of this project is to study bacteriophages and genetic exchange (mainly lysogenic conversion, transduction and transformation) in streptococci, and to investigate how such mechanisms may affect the pathogencity and immunology of these organisms. Currently we are searching for the nature and site of ...	{ "pile_set_name": "NIH ExPorter" }
During the coming year (1974) work on this project will include the following: 1. Completion of a detailed study of the locations, fine structural details and sources of the synaptic vesicles containing dense cores that are in or near the substantia gelatinosa of the spinal cord. The study will use cats, dogs and monke...	{ "pile_set_name": "NIH ExPorter" }
This proposal describes the continuation of a project that involves the synthesis of biologically active molecules containing, or derived from molecules containing the cyclopentenone ring system. Target molecules currently under investigation, and proposed target molecules for future research include quadrone, laurenen...	{ "pile_set_name": "NIH ExPorter" }
The identification of tumor suppressor genes has led to new insights into the mechanisms of human cancer development. The normal functions of these genes often lie in the control of gene expression, especially in the realm of cell cycle control and cellular differentiation. Several recent studies have implicated aberra...	{ "pile_set_name": "NIH ExPorter" }
This research utilizes the Operations Research approach to develop a method for effectively allocating high cost health services throughout a planning region. A set of mathematical models are formulated for forecasting service demands, optimally specifing service locations and quantity level, and simulating political r...	{ "pile_set_name": "NIH ExPorter" }
The proposed work is based on our observations that human blood group MN precursors, T (Thomsen-Friedenreich) and Tn (precursor of T) antigens are human carcinoma associated and that T antigen present on human breast carcinomata elicits both humoral and cell-mediated immune responses in patients with these malignancies...	{ "pile_set_name": "NIH ExPorter" }
This proposal requests partial support for a meeting on Iron Sulfur Enzymes as part of a the Gordon Research Conference series to be held in Stonehill College (Easton, MA) on June 15-20, 2014 with a broad and long-term goal of bringing together the world's leading experts in iron-sulfur enzymes, focusing on enzymatic m...	{ "pile_set_name": "NIH ExPorter" }
Increasing problems with rigidity, bradykinesia, tremor and gait disturbances are seen with advancing age. These movement dysfunctions are associated with a significant increase in morbidity and mortality in the elderly. Our studies in rhesus monkeys will initially focus on delineating the relationship between age-asso...	{ "pile_set_name": "NIH ExPorter" }
Gradual initiation of TMP/SMX as primary PCP prophylaxis.	{ "pile_set_name": "NIH ExPorter" }
This K23 award will allow Dr. Misty Hawkins, a clinical psychologist with expertise in behavioral medicine and obesity, to further develop into an independent investigator proficient in physiological, neuropsychological, and self-regulatory research methods and interventions that will allow her to study novel mechanism...	{ "pile_set_name": "NIH ExPorter" }
Project Summary/Abstract The National Cancer Institute (NCI) established the Cancer Genetics Network (CGN) in 1998 as a multi-centered national project designed to support collaborative investigations on the genetic basis of cancer susceptibility and to explore mechanisms to integrate this new knowledge into medical pr...	{ "pile_set_name": "NIH ExPorter" }
Amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) are fatal neurological disorders that involve the selective degeneration of spinal motor neurons. SMA ? the most common genetic cause of infant mortality ? is a monogenic disorder caused by widespread deficiency in the survival motor neuron (SMN) pro...	{ "pile_set_name": "NIH ExPorter" }
DESCRIPTION This is an application from the Association of American Medical Colleges (AAMC) that requests funding for four years to conduct a series of seminars and workshops involving 2 cohorts of 25 minority junior medical school faculty members. Each cohort would participate in a program lasting two years ( a total ...	{ "pile_set_name": "NIH ExPorter" }
Loss of life and non-fatal serious injuries are among the public health costs associated with alcohol related rashes. In order to develop successful public policies for reducing alcohol related crashes, it is necessary that we understand the causes of these crashes and how effective alternative public policies are in r...	{ "pile_set_name": "NIH ExPorter" }
We have been examining polymorphisms in genes involved in the leptin signaling pathway to identify gene variants impacting on body composition. We are currently intensively studying a variant MC3R that is associated with adiposity in children and which appears to have functional significance for MC3R signal transductio...	{ "pile_set_name": "NIH ExPorter" }
Camptothecin displays unprecedented antitumor activities against human colon cancer. To date its full therapeutic utility has been limited by poor water-solubility and the aqueous instability of the lactone ring moiety. Ring opening is rapid, resulting in a complete loss of biological activity. Int his communication, w...	{ "pile_set_name": "NIH ExPorter" }
MITOCHONDRIAL DYSFUNCTION is an important component of many of the pathologies associated with aging, such as type 2 diabetes mellitus, Alzheimer's disease, Parkinson's disease, and some cancers. Indeed, mitochondria have been implicated overall in the aging process, although the mechanisms are not fully understood. On...	{ "pile_set_name": "NIH ExPorter" }
This project will examine the beneficial effects of growth hormone and IGF-I in AIDS patients who are wasting. Ninety-five percent of this project is funded by Genetech, Inc. However, they have refused to pay for some ancillary studies which they feel are not necessary for FDA drug approval.	{ "pile_set_name": "NIH ExPorter" }
The San Antonio/Dallas Asthma and Allergic Diseases Cooperative Research Center represents an integrative, collaborative and innovative multidisciplinary effort to investigate the role of a unique Mycoplasma pneumonias toxin in asthma and related airway diseases. This toxin, designated Community Acquired Respiratory Di...	{ "pile_set_name": "NIH ExPorter" }
Multiple Myeloma (MM) is a disease of plasma cells with specific localization in the bone marrow. Recent studies in several malignancies including MM have shown intraclonal architectural heterogeneity at diagnosis and at different stages of disease progression over time. The presence of clonal tides in MM represent a n...	{ "pile_set_name": "NIH ExPorter" }
PROJECT SUMMARY Diarrheal disease causes close to one million deaths in children under five each year. Although its incidence is much lower in the more affluent nations, diarrhea remains one of the two most common visits to pediatric emergency rooms and is also common among the institutionalized elderly. NHE3 is a majo...	{ "pile_set_name": "NIH ExPorter" }
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which...	{ "pile_set_name": "NIH ExPorter" }
Keratoepithelin (KE) is an extracellular matrix protein encoded by the Big-h3 gene on human chromosome 5q. It is expressed in human cornea, skin and other tissues and its expression is up-regulated with TGFb. KE promotes the adhesion and spreading of dermal fibroblasts in vitro and cell-extracellular matrix interaction...	{ "pile_set_name": "NIH ExPorter" }
Core A. Abstract. The objective of Core A is to maintain a large collection of venoms and tissues from different Conus species and a collection of purified venom peptides, synthetic peptides and their analogs. Biological material will be obtained mainly from various locations in the Philippines. While the venom will be...	{ "pile_set_name": "NIH ExPorter" }
This randomized, controlled, open-label multi-center trial is designed to compare the intracellular delay in onset of suppression of HIV-1 viral replication within the first 72 hours of initiation of antiretroviral therapy using indinavir, or nevirapine, or combination zidovudine(ZDV)/3TC. All subjects receive four-dru...	{ "pile_set_name": "NIH ExPorter" }
This proposal is designed to provide information concerning the development of bacterial resistance to antibiotics that are frequently used as adjuncts in the treatment of destructive periodontal disease and to elicit the molecular mechanisms involved. Patients have been encountered whose disease condition does not res...	{ "pile_set_name": "NIH ExPorter" }
This proposal is a renewal of our EDRN Biomarker Reference Laboratory (BRL) which is located within the Clinical Chemistry Division (CCD) of the Johns Hopkins Medical Laboratories (JHML) at the Johns Hopkins Hospital. The BRL will continue to serve as a network resource for clinical and laboratory validation of biomark...	{ "pile_set_name": "NIH ExPorter" }
An integrated series of structural studies on the frog, xenopus and bovine retinal rod outer segment (ROS) is proposed. Studies include 1) determination of the z-projection of frog rhodopsin from 2-dimensional sheets (space group P22121; unit cell 47 A x 151 A), using glucose and auro-thio-glucose; 2) determination of ...	{ "pile_set_name": "NIH ExPorter" }
Ataxin-1 (Atx1) is a neurodegenerative disorder protein whose expanded glutamine-repeat form causes spinocerebellar ataxia type 1 (SCA1) in humans and which exerts cytotoxicity in mice and in Drosophila. Although the linkage between Atx1 and SCA1 has been established for more than a decade, the exact properties of Atx1...	{ "pile_set_name": "NIH ExPorter" }
Introduction. The mechanism of fluid transport across epithelia is not yet known with certainty. It is most frequently explained in terms of local osmosis. However, we have generated recent evidence suggesting that corneal endothelial fluid transport is instead due to electro-osmosis through the paracellular junctions....	{ "pile_set_name": "NIH ExPorter" }
SUMMARY Atherosclerotic plaque regression as a result of lipid-lowering treatment has been limited at best, with coronary artery disease (CAD) related event rates remaining unacceptably high. In this application, we propose that targeted immunomodulation of macrophages will resolve plaque inflammation and beneficially ...	{ "pile_set_name": "NIH ExPorter" }
DESCRIPTION: (applicant's abstract) The study of virus structure is both scientifically interesting and medically relevant. We seek to gain information on viruses by taking advantage of the inherent speed and accuracy of mass spectrometry and by using the techniques we have developed to study viral structure. While vir...	{ "pile_set_name": "NIH ExPorter" }
Successful orthopaedic management of displaced intra-articular fractures, to forestall post-traumatic osteoarthritis (OA), depends on avoidance of a mechanical environment that is deleterious to articular cartilage. Clinically, there are many reports of cases or series where patients have done surprisingly well in the ...	{ "pile_set_name": "NIH ExPorter" }
Cervical cancer is second to breast cancer as the most common form of malignancy in both incidence and mortality for women worldwide. The population-wide utilization of screening cervical cytology (Pap tests) has been associated with a dramatic decrease in morbidity and mortality from cervical cancer in the United Stat...	{ "pile_set_name": "NIH ExPorter" }
Ten thousand cord serum samples obtained from infants born from 1967 through 1971 are to be tested for cytomegalovirus IgM antibody by an indirect fluorescent method described by the principal investigator and his associates in 1968. Infants found to be positive will be followed for four to seven years after birth for ...	{ "pile_set_name": "NIH ExPorter" }
T. gondii is a major cause of neurologic disease in AIDS patients. Currently very few drug regimens have been shown to be effective in treating T. gondii infection, and thus alternative agents are needed. Potential therapeutic agents are screened in standard in vitro culture assays, as well as by an assay specific for ...	{ "pile_set_name": "NIH ExPorter" }
NCI Workforce Analysis Communication Products for the National Cancer Institute Division of Cancer Control and Population Sciences	{ "pile_set_name": "NIH ExPorter" }
Dengue hemorrhagic fever (DHF) is a severe manifestation of mosquito-borne dengue virus (DV) infection that is characterized by plasma leakage. Several factors are believed to be important in the pathogenesis of DHF, including host factors (e.g. HLA, pre-existing memory B and T cell responses), viral factors and entomo...	{ "pile_set_name": "NIH ExPorter" }
In recent years monoclonal antibodies (mAbs) recognizing tumor-associated antigens have increasingly been integrated into the clinical management of neoplasia and this trend is expected to continue. Prominent targets for antibody-based therapies are ErbB family members, including the epidermal growth factor receptor (E...	{ "pile_set_name": "NIH ExPorter" }
There is concern about the long-term use and abuse of benzodiazepine anxiolytic/hypnotic drugs by patients and polydrug abusers. One of the most insidious adverse effects of benzodiazepines is memory impairment. Five double-blind, placebo-controlled outpatient experiments are proposed in healthy volunteers to test spec...	{ "pile_set_name": "NIH ExPorter" }
The objectives of this study are to uncover the mechanisms by which aerogenic infection with facultative intracellular parasites is overcome. Syngeneic rats will be infected with either L. monocytogenes or M. tuberculosis which produce acute and chronic lung disease, respectively. Rats will be infected either aerogenic...	{ "pile_set_name": "NIH ExPorter" }
Human papillomaviruses (primarily HPV 16 and 18) play a central role in the development of in situ and invasive cervical cancer. Based on this observation and the well-recognized shortcomings of Pap smears, several groups have examined the use of HPV DNA testing as an adjunct to cytologic screening and found it to be c...	{ "pile_set_name": "NIH ExPorter" }
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is epidemic in the United States and other countries and poses a significant health and economic burden. As CA-MRSA is now the predominant MRSA clone in the community and in many healthcare settings, clinicians and infection control practitioner...	{ "pile_set_name": "NIH ExPorter" }
Neural reflexes rapidly adjust the cardiovascular system yet little is established about mechanisms governing their central nervous system pathways. The initial neurons are located within nucleus tractus solitarius (NTS). NTS integrates primary afferent information with CNS inputs. Our Research Plan will provide a cell...	{ "pile_set_name": "NIH ExPorter" }
The Minority Biomedical Research Support Program at SUNY/Old Westbury is designed to provide undergraduate minority students with experience in conducting meaningful contemporary biomedical research. The ultimate aim of the program is the encouragement of minority students to pursue advanced study and research careers ...	{ "pile_set_name": "NIH ExPorter" }
This project is a joint collaborative endeavor on the part of NIDR and of the Division of Computer Research and Technology, NIH. It is a laboratory automation project which is involved in the concurrent on-line acquisition and real time processing of data from a number of analytical instruments and experiments. The pro...	{ "pile_set_name": "NIH ExPorter" }
The Na-K-Cl cotransporter is a plasma membrane protein that plays a vital role in cellular and systemic electrolyte homeostasis. In non-polarized cells it is involved in regulation of cell volume and possibly of local extracellular potassium concentration; in transporting epithelia, it is a key element in balancing the...	{ "pile_set_name": "NIH ExPorter" }
PAR Leadership Training Foundation proposes to prepare for broadcast on public television an innovative series of thirteen videotaped workshop programs, for parents and others who work with young children, which will demonstrate the communication and learning values inherent in play, making it possible for adults of al...	{ "pile_set_name": "NIH ExPorter" }
Circadian rhythms are present in species throughout the animal kingdom. In humans, disorders of circadian timing contribute to circadian-based sleep disorders, maladjustment of shift workers and during jet lag, and may contribute to neuropsychiatric disorders including depression and seasonal affective disorder. A tran...	{ "pile_set_name": "NIH ExPorter" }
The purpose of this revised application is to expand and continue the research begun in the previous funding period, Treatment of Nicotine Dependence in an HMO Setting, in which 1,524 individuals enrolled in a health care system received treatment with bupropion SR and behavioral counseling and were then followed for 1...	{ "pile_set_name": "NIH ExPorter" }
PROJECT SUMMARY Background: Effective scalable water, sanitation, and hygiene (WASH) interventions are urgently needed to reduce pediatric diarrheal disease globally. Phone based reminders is an emerging low cost approach shown to lead to improved disease prevention practices. Objective: The purpose of this study is to...	{ "pile_set_name": "NIH ExPorter" }
The purpose of this application is to request partial support of the travel expenses for invited speakers to the 42nd Gordon Research Conference on Cancer. The conference is entitled "Cancer-Genetics" and will take place August 12-17 at Salve-Regina College in Newport, Rhode Island. The Cancer Conference is the oldest ...	{ "pile_set_name": "NIH ExPorter" }
Our objective is to provide a centralized, publicly available resource with comprehensive, well-annotated data and analysis tools that informs design and interpretation of environmental health studies and promotes novel insights into the etiologies of environmentally influenced diseases. Most human diseases involve int...	{ "pile_set_name": "NIH ExPorter" }
Evidence is presented which suggests a) that the pathogenetic basis of the syndrome of absorptive hypercalciuria is a disordered control of 1,25-dihydroxyvitamin D (1,25-OH)2D production, b) that "dietary" hypercalciuria, apparently largely sodium-induced, is a common clinical syndrome, contributing to the hypercalciur...	{ "pile_set_name": "NIH ExPorter" }

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