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This application is to request three years of funding for the annual Winter Conference on Brain Research (WCBR). The 2019 meeting will take place Snowmass Village and Conference Center, Snowmass, CO between Tuesday January 29-Saturday February 2. This conference is an ideal forum for exploring new developments in the f...	{ "pile_set_name": "NIH ExPorter" }
ABSTRACT Support is requested for a Keystone Symposia meeting entitled RNA-Based Approaches in Cardiovascular Disease, organized by Drs. Thomas Thum and Roger J. Hajjar. The meeting will be held in Keystone, Colorado from March 26-30, 2017. Cardiac diseases are the leading cause of death worldwide. RNA-based mechanisms...	{ "pile_set_name": "NIH ExPorter" }
Evidence suggests that for the most part gp4l neutralizing epitopes are cryptic, and this is most likely related to the functional role of the transmembrane protein (TM) in mediating virus entry. It has been shown that gpl2O-CD4 binding causes the HIV envelope to undergo a series of conformational changes, which may be...	{ "pile_set_name": "NIH ExPorter" }
DESCRIPTION: Females produce speech with a higher fundamental frequency (f0, voice pitch) as compared to male-produced speech. This higher f0 results in relative under sampling of the spectral envelope which should, in turn lead to lower intelligibility. However, excerpts from natural speech produced by females is as o...	{ "pile_set_name": "NIH ExPorter" }
The overall objectives of our current MBRS program are to: (a) provide research experiences for undergraduate and M.S. level graduate students; (b) provide a vehicle for research for faculty at our institution; (c) provide an institutional model for research; (d) increase the pool of minority students who will enter te...	{ "pile_set_name": "NIH ExPorter" }
Ions are essential components of biomolecular systems. One third of all proteins contain metal ions as integral parts for structural or functiona purposes. Binding of negatively charged phosphate groups is ubiquitously involved in regulation, signal transduction and various other processes. Whereas is a plethora of exp...	{ "pile_set_name": "NIH ExPorter" }
Muscle and nerve cell functions are largely due to the function of transmembrane ion channels. Mutations in ion channel genes can lead to uncoordinated movement, or to the loss or attenuation of particular behaviors. The role of a particular potassium channel and its regulators in coordinating muscle contraction and in...	{ "pile_set_name": "NIH ExPorter" }
PROJECT SUMMARY/ABSTRACT: Immunotherapy with monoclonal antibodies (mAbs) has been successful in settings such as autoimmunity and cancers, and therefore, treatment options with antibodies especially re-designed molecules based on broadly neutralizing antibodies (bNAbs) should be explored in the context of HIV-1. A cav...	{ "pile_set_name": "NIH ExPorter" }
The goal of this research program is to construct a model of human red/green color-vision defects that is based upon the molecular biology of the color-vision genes. In the April 11, 1986 edition of Science, Nathans and colleagues (including one of the authors of this proposal (Piantanida)), reported (1) the nucleotide...	{ "pile_set_name": "NIH ExPorter" }
We propose a demonstration and dissemination project that extends a cardiovascular disease risk-reduction program shown to be effective among patients with Diabetes Mellitus (DM) in an integrated HMO population, to a vulnerable outpatient population receiving DM care in 11 Federally Qualified Health Center (FQHC) clini...	{ "pile_set_name": "NIH ExPorter" }
The importance of hydrophobicity in protein folding is universally recognized. A particularly exciting phenomenon is the sudden large scale de-wetting transition that occurs as two large hydrophobic solutes are brought together. But are biological systems like proteins prone to such drying transitions? We have recently...	{ "pile_set_name": "NIH ExPorter" }
Work on the obtainment, examination, review, and interpretation of data relating to cancer mortality that have been produced historically in successive studies from the General Registrar Office of England and Wales. This shall include analysis of relation of mortality from cancer to occupation and social class, analysi...	{ "pile_set_name": "NIH ExPorter" }
Deliberation entails the serial examination and evaluation of outcomes. While there are detailed, mechanistic, and quantitative theories of non-deliberative decision-making, such theories of deliberative decision-making are still lacking. This is due to a lack of key experimental knowledge of the mechanisms of delibera...	{ "pile_set_name": "NIH ExPorter" }
It has been estimated that more than one third of patients with neurological disorders with problems affecting the neuromuscular system. Striking progress has been made in understanding many of these diseases, and in the effective application of the new knowledge to treatment. This progress has been made possible by th...	{ "pile_set_name": "NIH ExPorter" }
In recent years, pain research has made revolutionary advances at levels ranging from genes to behavior. However, one basic level of organization that has proved particularly resistant to analysis is the intrinsic circuitry underlying pain transmission and modulation within the first central relay area, the spinal dors...	{ "pile_set_name": "NIH ExPorter" }
We have been investigating a number of biophysical processes associated with nerve excitation and their relationship to the MR signal. Uri Nevo, a former STBB post-doctoral fellow, and now an Assistant Professor at Tel Aviv University, successfully constructed and tested an experimental system in our lab to interrogate...	{ "pile_set_name": "NIH ExPorter" }
The overall long term objectives of the studies proposed in this application are to identify and to understand the ionic mechanisms that underlie the abnormalities in the transmember potentials of the subepicardial ventricular cells that survive in the epicardial border zone of the infarcted heart. It has been suggeste...	{ "pile_set_name": "NIH ExPorter" }
Avoidance of autoimmunity appears to rely on a carefully orchestrated series of activities involving an appropriate interplay between genetics, the environment, and components of both the innate and adaptive (acquired) immune systems. When this process fails, a variety of autoimmune disorders can arise; including type ...	{ "pile_set_name": "NIH ExPorter" }
A continued collaboration with the Naval Research Laboratories has enabled a SQUID magnetometer to be used to study inter-ictal spike discharges in epileptic patients. Correlation of the MEG activity and the corresponding EEG signal for these discharges permits signal averaging of spikes associated with the same neurol...	{ "pile_set_name": "NIH ExPorter" }
The specific aims for the project are 1) to develop technical quality of care measures for asthma that are valid, reliable, sensitive and specific and have predictive value related to asthma outcomes, and can be easily and inexpensively applied in the health care setting used, 2) to assess whether the technical quality...	{ "pile_set_name": "NIH ExPorter" }
Due to their recent demonstration of efficacy in a number of malignancies, monoclonal antibodies (MAb) are becoming increasingly important in cancer therapy. Most efforts to develop new antibody-based molecules are focused on identifying those with the highest possible affinity for the tumor antigen. Using small, singl...	{ "pile_set_name": "NIH ExPorter" }
White adipose tissue (WAT) is the main lipid reservoir that becomes dysfunctional in obesity. It is important to understand how breached lipid homeostasis leads to metabolic disease. Efficient long chain fatty acid (FA) and cholesterol trafficking depends on a transmembrane transporter protein CD36. However, the mechan...	{ "pile_set_name": "NIH ExPorter" }
Victimization of young, college women is a problem with potentially devastating consequences. Approximately 2 million women are new freshmen each year (US Dept. of Ed., 2001 ). In a recent report, Hingson et al. (2002) estimate that 600,000 (13.3%) college students were assaulted because of drinking by other students o...	{ "pile_set_name": "NIH ExPorter" }
Previous work has shown that in frog striated muscle fibers there is a mechanical coupling between the sarcolemma and the column of interdigitating arrays of myofilaments. An ultrastructural study will be made of myofibers, at points where special stress or strain of this coupling can be expected, in an attempt to find...	{ "pile_set_name": "NIH ExPorter" }
This research will define the mechanisms by which the immune system initiates and controls inflammation. We will evaluate biochemical processes involved in the chemotactic responses of polymorphonuclear leukocytes (PMNs), monocytes, and macrophages. We will characterize receptors for chemotactic factors on leukocytes a...	{ "pile_set_name": "NIH ExPorter" }
Although obesity is one of the outstanding health problems in the United States, little is known about the factors which lead to its development at the cellular level. The aims of this research are to delineate some of the enzymatic profiles of adipose tissue during its normal growth and development and during the deve...	{ "pile_set_name": "NIH ExPorter" }
The purpose of the project is to study the chemical and physical properties and metabolism of proteoglycans in a number of tissue and cell systems. Topics of present interest include: 1) Protein chemistry and immunology of the core protein of proteoglycans from the Swarm rat chondrosarcoma; 2) Biosynthesis of core prot...	{ "pile_set_name": "NIH ExPorter" }
This is the administrative core for the Southeastern STI CRC (SE STI CRC), in which 6 projects and 3 cores are united under the general theme "STI Prevention". Core A supports time and effort for the PI (P Frederick Spariing), the co PI (Marcia Hobbs) and administrative assistant Sharon Graham as well as a part time ac...	{ "pile_set_name": "NIH ExPorter" }
Heavy habitual consumption of alcohol leads to progressive injury and fibrosis in several tissues, including the liver. However, many heavy drinkers do not develop advanced liver fibrosis (i.e., cirrhosis) despite years of alcohol abuse. More modest consumption of alcohol (<2drinks/day) has actually been associated wit...	{ "pile_set_name": "NIH ExPorter" }
The long-range objective is to understand enough about the factors that control mammalian cell growth to be able to apply this knowledge to the control of malignant growth. As a result of recent work, a broad picture is now available of the control of growth of mammalian cells. Application of this knowledge requires ad...	{ "pile_set_name": "NIH ExPorter" }
In our 1 M GWAS, 4 of the 10 SNPs most significantly associated with body mass index (BMI) mapped near or within the MAP2K3 gene. Fine mapping of this region revealed that specific regions of this locus were duplicated, and a large number of the database SNPs from this region were false SNPs. Validated SNPs that mapped...	{ "pile_set_name": "NIH ExPorter" }
The Comprehensive Oral Health Research Center of Discovery (COHRCD) at The University of Iowa will focus on craniofacial anomalies. A comprehensive set of major research projects coupled to technology transfer and the development of new research opportunities through pilots will be supported by a core infrastructure re...	{ "pile_set_name": "NIH ExPorter" }
The main objective of the interdisciplinary Prevention And Methodology Training (PAMT) program (T32 DA017629) is to produce two types of well-trained scientists: prevention scientists who apply the most appropriate methodology in their research and can do this even when the methodology is advanced and cutting-edge; and...	{ "pile_set_name": "NIH ExPorter" }
We compared the regional myocardial distribution of the commonly used flow indicators; flow limited iodoantipyrine, partially flow limited rubidium chloride and 9uM microsphere. The analysis of such data, given the appropriate mathematical model, may give answers to a) the correction factors for flow measurements, b) d...	{ "pile_set_name": "NIH ExPorter" }
Leukocyte adhesion must be tightly controlled for leukocytes to patrol the body as non-adherent cells, yet stop and emigrate from the blood into tissues at sites of infection or inflammation. This involves control adhesiveness of both the leukocyte and the endothelial cell to which it adheres. While some of this contro...	{ "pile_set_name": "NIH ExPorter" }
The project calls for the maintenance of the following CTEP Information Systems: the Main Administrative System, the Phase II System, and the Drug Distribution and Protocol Monitoring System (DDPMS) with further development of linkages between these systems and with outside data bases. This project is a recompetition o...	{ "pile_set_name": "NIH ExPorter" }
This Competitive Renewal will build upon biomarker discoveries from the previous period. In four Aims we will focus upon the overall hypothesis that inflammatory candidate biomarkers identify patients at risk for incident symptomatic knee OA (SKOA), or those patients with established SKOA, who are at increased risk for...	{ "pile_set_name": "NIH ExPorter" }
This NICHD Ruth L. Kirschstein National Research Service Award application seeks to continue to train pre-doctoral students in reproductive, perinatal, and pediatric epidemiology. This field has experienced slower growth relative to other fields in epidemiology, despite a clear public health need. The long-term objecti...	{ "pile_set_name": "NIH ExPorter" }
In this revised application for a Mentored Patient Oriented Research Career Development Award, the candidate, Smit S. Sinha, will develop expertise in the psychoneuroendocrinology of anxiety, with emphasis on the endogenous opioid system and its interactions with the hypothalamic-pituitary-adrenal axis in panic disorde...	{ "pile_set_name": "NIH ExPorter" }
The field of atherothrombosis is poised for advances in basic science and novel therapeutics, yet faces considerable challenges to clinical translation due to 1) the very success of current therapies (rendering event rates low and hence clinical trials large and lengthy) and 2) the lack of validated predictors of clini...	{ "pile_set_name": "NIH ExPorter" }
We have shown that trans-rearrangements between (rather than within) antigen receptor genes are formed by site-specific recombination between variable segments from one immune receptor locus and joining segments from another. We have demonstrated that such events occur in the peripheral T-cells of all normal individual...	{ "pile_set_name": "NIH ExPorter" }
In brain, the over-activity of stress hormones and endogenous excitatory amino acids (EAA) causes shortening of dendrites in the CA3 region and suppresses neurogenesis in the dentate gyrus (DG). Yet, even these changes, although impairing some functions such as declarative memory, may not constitute "damage" but rather...	{ "pile_set_name": "NIH ExPorter" }
There is a need to determine in more detail the biological, psychological, and social factors involved in tobacco smoking behavior in persons who are aware of the harmful health consequences of continued tobacco use. The brain is the principal organ of behavior in the body. Hence, a great deal of interest is not focuse...	{ "pile_set_name": "NIH ExPorter" }
Pancreatic ductal adenocarcinoma (PDAC) is a painful, deadly, and incurable disease for which effective treatments remain to be discovered and tested. The OVERALL OBJECTIVES of this study are to define mechanisms underlying the regulation of PDAC cell growth, by focusing on further characterizing a novel pathway for wh...	{ "pile_set_name": "NIH ExPorter" }
In simplest terms, osteoarthritis can be understood as the wearing away of articular cartilage, a tissue with a limited ability to repair itself. Findings from recent studies suggest that progressive degradation in cartilage after injury is closely related to the elevation and activation of specific enzymes, called met...	{ "pile_set_name": "NIH ExPorter" }
The initial research in this proposal will define and compare the molecular effect of the juvenile hormone mimics (Altosid TM and Altosar TM) with juvenile hormone on the insect vitellogenic system. Such a study will determine the mechanism of action (i.e., mode of action at the level of translation and/or transcriptio...	{ "pile_set_name": "NIH ExPorter" }
DESCRIPTION: (Applicant's Abstract) Persistent corneal wounds with epithelial defects pose therapeutic challenges to the clinician and can result in ocular morbidity, visual damage, and increase the patient's risk for potential eye loss. Currently, there are no approved clinical treatments that accelerate and/or promot...	{ "pile_set_name": "NIH ExPorter" }
Lymphoid stem cells (also termed common lymphoid progenitors or CLPs) are clearly defined by their ability to differentiate exclusively into each type of lymphocyte. Our preliminary data suggest that numbers of CLPs in adult mouse bone marrow are significantly reduced in aged mice, suggesting that previously reported d...	{ "pile_set_name": "NIH ExPorter" }
We propose to undertake a broad multidisciplinary approach to drug abuse problems. Chemical, biochemical, pharmacological, physiological, and behavioral techniques will be used to explore marihuana, the narcotics and narcotic-antagonists, the inhalants, and other classes of abused substances. Specific binding of the ca...	{ "pile_set_name": "NIH ExPorter" }
We are investigating the kinetics and chemistry of isoenzymes of yeast alcohol dehydrogenase which have been produced by mutation and selection in our laboratory. It is our hope that these investigations will lead to a better understanding of the function of this and other enzyme molecules, through a determination of w...	{ "pile_set_name": "NIH ExPorter" }
At present, positive pressure ventilation is usually applied with large tidal volumes and only exceptionally at respiratory rates above 20 per minute. A novel method of jet ventilation uses instead of endotracheal tube a small cannula introduced transtracheally or between the vocal cords to inject jets of oxygen in the...	{ "pile_set_name": "NIH ExPorter" }
PROJECT SUMMARY Alcohol consumption has been linked to increased risk of colorectal cancer (CRC). However, the underlying mechanisms have not yet been fully defined. Emerging evidence from animal studies suggest that alcohol associated gut dysbiosis and subsequent gut barrier dysfunctions and endotoxemia may be an impo...	{ "pile_set_name": "NIH ExPorter" }
Studies directed toward the total synthesis of Harringtonine and related alkaloids will be continued. The proposed route involves a convergent synthesis of Cephalotaxine via conjugate - addition reactions of functionalized organometallic reagents to gamma-oxido vinyl sulfones.	{ "pile_set_name": "NIH ExPorter" }
A population-based case-control study of lung cancer is proposed to determine if employment in wood-related occupations is associated with increased risk of lung cancer, and to identify specific exposures in these jobs which might explain any increased risks found. Specifically, we will: a) test the hypothesis that per...	{ "pile_set_name": "NIH ExPorter" }
PROJECT SUMMARY In humans, it is clear that reduced function of the circadian clock is associated with increased incidence of neurodegeneration (e.g., Alzheimer?s Disease; AD). While it has been hypothesized that circadian dysfunction and neurodegeneration may be linked, the mechanism for these proposed links remains u...	{ "pile_set_name": "NIH ExPorter" }
These studies are intended primarily to characterize the mechanisms involved in active calcium transport by renal epithelia. Proposed experiments include examination of the membrane processes and second messengers involved in parathyroid hormone (PTH) stimulation of calcium absorption in renal cortical thick ascending ...	{ "pile_set_name": "NIH ExPorter" }
The rapid rise in atmospheric CO2 levels presents a significant long-term threat to human health.(1) Much of the current rise in CO2 levels may be ascribed to the use of non-renewable fuels and, as a result, there has been great interest in studying energy conversion reactions such as H+ reduction and H2 oxidation.(2) ...	{ "pile_set_name": "NIH ExPorter" }
Recent nmr studies which have provided new evidence for the catalysis of a number of reactions of amino and keto acids by vitamin B6 (pyridoxal or pyridoxamine, respectively) are being followed up by studies of reaction pathways by several methods. These techniques include effect of structure of substrate and catalyst ...	{ "pile_set_name": "NIH ExPorter" }
Tuberculosis is almost a uniquely human condition because, although the bacterium can infect a range of hosts, it only proceeds to transmission in humans and higher primates. Transmission is a consequence of the tissue response to the bacterium that is probably driven by bacterial components released by the intracellul...	{ "pile_set_name": "NIH ExPorter" }
Abstract Neuropathic pain reflects a myriad of changes in the periphery, spinal cord, and subcortical and cortical structures. Interestingly, despite this baffling array of changes, many approved treatments for neuropathic pain recruit, augment, or mimic bulbospinal inhibition including morphine, noradrenaline (NA) re-...	{ "pile_set_name": "NIH ExPorter" }
During the past funding cycle, our research has emphasized the importance of the NAD(P)H oxidase as a source of reactive oxygen species and confirmed that it plays a crucial role in the hypertension caused by angiotensin II. In addition, we have shown that the extracellular superoxide dismutase (ecSOD) seems to play an...	{ "pile_set_name": "NIH ExPorter" }
Project Summary/Abstract Alzheimers disease (AD) is characterized by the deposition of amyloid B protein (AB), a small peptide derived from B- and y-secretase cleavages of the amyloid precursor protein (APP). We recently demonstrated that the last 37 amino acids (LRP-C37) of low-density lipoprotein receptor-related pro...	{ "pile_set_name": "NIH ExPorter" }
To assess the effect of an acute insulin infusion on the metobolic clearance rate of dehydroepiandrosterone in elderly men and women.	{ "pile_set_name": "NIH ExPorter" }
Abstract Chronic heart failure, the final step of different cardiovascular diseases (CVD), remains the leading cause of cardiovascular death without a cure. To date, the therapeutic approaches by blocking or inhibiting over-activated single pathway such as inflammatory cytokines and oxidative stress which have been fir...	{ "pile_set_name": "NIH ExPorter" }
Besides unique patients with immunodeficiency and immunodysregulation disorders lacking known diagnoses, our intake includes patients with combined immunodeficiency, common variable immunodeficiency (CVID), variants of hyper-IgE syndrome or autoimmune lymphoproliferative syndrome (ALPS), Evans syndrome, caspase-8-defic...	{ "pile_set_name": "NIH ExPorter" }
The genetics of rheumatoid arthritis suggest that a combination of inherited alleles and environmental factors contribute to the development of arthritis. T cell reactivity is implicated in RA based on the linkage of RA to particular MHC alleles. Our animal model, proteoglycan-induced arthritis (PGIA) has many similari...	{ "pile_set_name": "NIH ExPorter" }
Pre-exposure prophylaxis (PrEP) refers to daily or intermittent oral administration of antiretroviral drugs designed to protect high-risk HIV-negative individuals from infection. As PrEP is, at present, the most promising biomedical prevention tool, the Centers for Disease Control and Prevention (CDC) is currently revi...	{ "pile_set_name": "NIH ExPorter" }
This is a proposed K24 award for Dr. Frederick Hecht, Professor of Medicine at the University of California (UCSF), and director of research at the UCSF Osher Center for Integrative Medicine. Dr. Hecht is an internist with postdoctoral training in clinical epidemiology. He is director of the T32-funded UCSF Training in...	{ "pile_set_name": "NIH ExPorter" }
This program of research proposes to examine immunological and viral-immunological factors and interactions which may be involved in the pathogenesis of multiple sclerosis (MS). The laboratory models that will be utilized include acute and chronic experimental allergic encephalomyelitis (EAE) in its usual state as well...	{ "pile_set_name": "NIH ExPorter" }
The overall goal of this project is to enhance the detection, assessment and family care of Alzheimer's disease in the rural counties of West Virginia through a state-wide educational program. The specific aims include: 1) to provide training in assessing the cognitive status of elderly clients and the adequacy of thei...	{ "pile_set_name": "NIH ExPorter" }
Pre-mRNA splicing is essential for gene expression in all eukaryotes and errors in splicing cause genetic disorders and many other diseases. Mutations in splicing factor Prp8, for example, cause a severe form of human genetic disorder Retinitis Pigmentosa. A thorough understanding of the molecular mechanisms of pre-mRN...	{ "pile_set_name": "NIH ExPorter" }
Escalating societal concern over the risks of exposure to extremely low frequency (ELF) electromagnetic fields has been fueled by epidemiologic studies which correlate increased incidence of leukemia or birth defects with proximity to power distribution systems. Unfortunately, the phenomenologic nature of these studies...	{ "pile_set_name": "NIH ExPorter" }
The proposed study has three central objectives: 1) an evaluation of the impact of the new Massachusetts mental health law on involuntary civil commitment of the mentally ill; 2) the preliminary development and evaluation of a "dangerous to others" assessment instrument; and 3) a survey of legal and psychological conce...	{ "pile_set_name": "NIH ExPorter" }
Gene targeting, homologous recombination between a newly added, exogenous DNA sequence and the cognate chromosomal sequence, in mouse embryo-derived stem (ES) cells allows the specific modification of any chosen genetic locus in living mice. First, a cloned copy of the chosen gene is mutated in vitro using standard rec...	{ "pile_set_name": "NIH ExPorter" }
The ability to elicit Abs with broad neutralization activity against HIV-1 has been a long sought-after but elusive goal of HIV/AIDS vaccine research. The long-term goal of this proposal is to understand how broad-spectrum neutralizing antibodies (BnAbs) are generated. The majority of the rare BnAbs (2F5, 4E10 and b12)...	{ "pile_set_name": "NIH ExPorter" }
This project is designed to investigate alternative methods of infecting Macaca nemestrina with HIV-1 to enhance pathogenesis. One method, direct inoculation of bone marrow with subsequent in vivo passage of bone marrow, was concluded early in 1998. This route of infection did not appear to enhance pathogenesis in this...	{ "pile_set_name": "NIH ExPorter" }
Various homologs of cannabidiol (CBD) were synthesized where the aromatic side chain was replaced by H and C1 to C9. They were prepared to study the SAR with regard to anticonvulsant activity. The syntheses were accomplished by condensing the appropriate resorcinol with p-mentha-2,8-dien-1-o1 in the presence of less th...	{ "pile_set_name": "NIH ExPorter" }
PRINCIPAL RESEARCH CORE a) Intervention Development Program- This Program will focus on developing innovative patientcentered interventions for mood disorders. To facilitate dissemination and implementation, we will emphasize the core values of efficiency, portability across a range of clinical settings and flexibility...	{ "pile_set_name": "NIH ExPorter" }
The effect of retrovenous, hypothermic, diastolic myocardial perfusion (RVDP) (myocardial oxygen supply) combined with ventricular unloading (myocardial oxygen demand) will be studied in sheep subject to coronary artery ligation. Percent salvage of injured myocardium at risk and prevention of necrosis as assessed by ra...	{ "pile_set_name": "NIH ExPorter" }
During this past year we have made major progress on developing and applying several of the essential modeling methodologies for input/output, or nonparametric, models of point-process input neural systems such as the hippocampus. First, we have pursued development and application of adaptive estimation procedures for ...	{ "pile_set_name": "NIH ExPorter" }
Unraveling the molecular mechanisms which promote the development of asthmatic inflammation represents one of the most challenging and important areas that need to be elucidated in order to understand this disease. We hypothesize that interactions between the innate and adaptive immune systems alter airway cells in a m...	{ "pile_set_name": "NIH ExPorter" }
The primary objective of the Immune Analysis Core is to establish standardized assays of cellular and humoral immune responses for the immunotherapeutic approaches being developed and tested in Individual Research Projects 1, 2 and 3 of the RPCI Ovarian Cancer SPORE. It will be also be responsible for enumerating and c...	{ "pile_set_name": "NIH ExPorter" }
Project Abstract The primary objective of this proposal is to develop and commercialize a safe and more effective therapy for the treatment of Crohn's Disease, an inflammatory bowel disease. Crohn's Disease is a chronic inflammatory disorder of the gastrointestinal tract that affects some 500,000 patients in the US. Se...	{ "pile_set_name": "NIH ExPorter" }
The purpose of this Core is to provide the high degree of technical expertise required to perform and nterpret advanced MR imaging studies, to facilitate the collection of image guided surgical specimens and to relate the quantitative information derived from the imaging data to molecular markers of the biological prop...	{ "pile_set_name": "NIH ExPorter" }
These experiments have been initiated to characterize embryonic stem cells, especially human embryonic stem cells (hESC), for studies of human dopaminergic neuronal function. In spite of the great importance of dopaminergic neurons for drug abuse, in addition to their therapeutic potential via transplantation, there ha...	{ "pile_set_name": "NIH ExPorter" }
Asthma and allergic rhinitis, the most common chronic diseases of childhood in the United States, are major public health problems. Characterized by variable airflow obstruction and airway inflammation, childhood asthma is thought to have its origins in fetal and infant development. Environmental exposures influencing ...	{ "pile_set_name": "NIH ExPorter" }
Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths among American Indian and Alaska Native (AI/AN) populations. Further, AI/ANs are twice as likely to be diagnosed with advanced rather than localized CRC compared to non-Hispanic Whites, suggesting that lack of access to adequate cancer screen...	{ "pile_set_name": "NIH ExPorter" }
A robust Pilot and Feasibility Program will be an integral portion of the CONSORTIUM FOR HEREDITARY CAUSES OF NEPHROLITHIASIS AND KIDNEY FAILURE. The Rare Diseases Consortium will serve as an active incubator for novel ideas in nephrolithiasis research and patient care. Plans are to fund 2 projects at all times for the...	{ "pile_set_name": "NIH ExPorter" }
Patient engagement in HIV care encompasses a cascade of events from HIV diagnosis to retention in care. Each step is vital in achieving the goal of virologic suppression and improved health outcomes. Compromising this clinical imperative is the nearly 50% of HIV-infected individuals in the US who are not in continuous ...	{ "pile_set_name": "NIH ExPorter" }
This proposal will evaluate the immunoregulation that develops during adoptively transferred or actively induced Experimental Allergic Encephalomyelitis (EAE). The analysis will involve donor contribution to the disease process, variables associated with the obligatory in vitro expansion of a transfer active cell popul...	{ "pile_set_name": "NIH ExPorter" }
The last months of pregnancy are particularly important for the development of the child's brain, and the consequences of premature birth on its development can be substantial. Prematurely born children are at higher risk of various cognitive impairments and exhibits more behavioral disorders than full-term born childr...	{ "pile_set_name": "NIH ExPorter" }
Sepsis represents the systemic response to infection, and the ensuing inflammatory cascade leads to the development of multi-organ failure and high mortality. The acute respiratory distress syndrome (ARDS) represents a process of devastating lung injury that complicates sepsis and contributes to propagation of the host...	{ "pile_set_name": "NIH ExPorter" }
Although Alzheimer's Disease (AD) is characterized classically by dementia associated with a variety of neuropathologic features, it is likely that there is no single pathologic change that alone is the basis for the cognitive and behavioral impairment. In this proposal, we hypothesize that the pathogenetic mechanism f...	{ "pile_set_name": "NIH ExPorter" }
Lung cancer is the leading cause of cancer-related death in the United States and is responsible for over 160,000 patient deaths from their lung cancer this year, more than that of breast, colorectal, prostate, colon and other cancers combined. With the existing therapeutic efforts, patients with lung cancer have a 5-y...	{ "pile_set_name": "NIH ExPorter" }
The information required for adequate diagnosis, treatment and monitoring of cancers is so complex that a panel of measurements, used in sum, may provide the best answers. The concept is embodied in SELDI-TOF mass spectrometric (MS) peptide profiling, an emerging technique for serum based cancer detection. Even though ...	{ "pile_set_name": "NIH ExPorter" }
Normal activity of salivary glands is controlled by neural stimulation and recent studies on rodents suggest that experimental stimulation with synthetic catecholamines, especially isoproterenol (ISP), leads to alteration of salivary gland structure and function. This study is proposed to determine the role of the Beta...	{ "pile_set_name": "NIH ExPorter" }
The Sexually Dimorphic Nucleus of the Preoptic Area (SDN-POA) of the rat hypothalamus is a morphological marker of the process of sexual differentiation of the brain. The differentiation of this nucleus (in terms of volume) takes place during the neonatal life of the animal. In addition, this process is influenced by t...	{ "pile_set_name": "NIH ExPorter" }
DESCRIPTION: This proposal is directed at understanding the requirements for proper chromosome segregation during mitosis. Using a clever screen to detect mutations which lead to increases in ploidy, the PI previously isolated a conditional mutation in the IPL1 gene which has significant sequence homology with a number...	{ "pile_set_name": "NIH ExPorter" }
As a working hypothesis a model of protein folding has been developed. The three-dimensional screened precession data of crystals of Nuclease-T (an enzymically active, non-covalent complex of two fragments of staphylococcal nuclease, residues 6-48 and 49-149) bound with deoxythymidine-3'-5'-diphosphate (pdTp) and Ca2 i...	{ "pile_set_name": "NIH ExPorter" }
This phase I/II study evaluated the safety, tolerance, pharmacokinetics and antiviral activity of the anti-HIV antisense oligonucleotide GEM 91 administered by continuous intravenous infusion for up to 14 days. The drug infusion produced transient elevation of hepatic transaminases in a few subjects, transient mild thr...	{ "pile_set_name": "NIH ExPorter" }

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