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### Instruction:
Is hyperinsulinemia caused by dexamethasone treatment associated with reduced insulin clearance and lower hepatic activity of insulin-degrading enzyme?
### Response:
| In conclusion, the reduced insulin clearance in glucocorticoid-treated rodents was due to the reduction of hepatic IDE activity, at least in rats, which may contributes to the compensatory hyperinsulinemia. These findings corroborate the idea that short-term and/or partial inhibition of IDE activity in the liver could ... |
### Instruction:
Does single-cell transcriptomic reconstruction reveal cell cycle and multi-lineage differentiation defects in Bcl11a-deficient hematopoietic stem cells?
### Response:
| Our study demonstrates the power of single-cell transcriptomics in dissecting cellular process and lineage heterogeneities in stem cell compartments, and further reveals the molecular and cellular defects in the Bcl11a-deficient HSC compartment. |
### Instruction:
Does type-2 diabetes increase autophagy in the human heart through promotion of Beclin-1 mediated pathway?
### Response:
| These findings demonstrate the pathological role of autophagy in the type-2 diabetic heart, opening up a potentially novel therapeutic avenue for the treatment of diabetic heart disease. |
### Instruction:
Does transmission of ER stress response by ATF6 promote endochondral bone growth?
### Response:
| Our observations demonstrate that ATF6 positively regulates chondrocyte hypertrophy and endochondral bone formation through activating Runx2-mediated hypertrophic chondrocyte differentiation. |
### Instruction:
Is deficiency of P-selectin glycoprotein ligand-1 protective against the prothrombotic effects of interleukin-1β?
### Response:
| Our data demonstrate that Psgl-1 deficiency is protective against the prothrombotic effects of IL-1β and suggest that Psgl-1 inhibition may be a useful treatment strategy for targeting vascular thrombosis associated with enhanced inflammatory states. |
### Instruction:
Is gardening beneficial for adult mental health : Scottish Health Survey , 2012-2013?
### Response:
| General adults with or without heart conditions could benefit from engaging with gardening or building work. Future public health programmes promoting such activity should be encouraged in order to optimise adult mental health. |
### Instruction:
Do epithelial-mesenchymal transformation markers E-cadherin and survivin predict progression of stage pTa urothelial bladder carcinoma?
### Response:
| Adding the immunohistochemical markers survivin and E-cadherin could help to identify patients at risk of developing a progressive disease in initial stage pTa bladder cancer. |
### Instruction:
Do essential phospholipids prevent islet damage induced by proinflammatory cytokines and hypoxic conditions?
### Response:
| EPL could be a potent agent to protect islets from inflammatory and hypoxic conditions after isolation procedures. Further studies to clarify the effect of EPL in islet transplantation are warranted. |
### Instruction:
Are mCP-1 and soluble TWEAK levels independently associated with coronary artery disease severity in patients with chronic kidney disease?
### Response:
| Our findings support a relationship between sTWEAK and MCP-1 levels and CAD in CKD stages 2-3 patients. |
### Instruction:
Do whole mount immunofluorescence analysis of placentas from normotensive versus preeclamptic pregnancies?
### Response:
| Our study demonstrates that increased pSTAT3 expression in placental endothelial cells is associated with PE. We speculate that elevated pSTAT3 expression in the blood vessels of PE placentas may be due to aberrant angiogenesis, increased pro-inflammatory cytokine expression, and/or placental stress. |
### Instruction:
Does repeated Elevation of the Anterolateral Thigh Flap for Lower Extremity Orthopedic Trauma Affect Flap Viability?
### Response:
| We conclude, therefore, there is no elevated risk to long-term viability by elevating the ALT flap. This combined with the ease of elevation makes it a safe procedure to be performed as needed for access to the deep tissues. |
### Instruction:
Is everolimus safe within the first month after liver transplantation?
### Response:
| Everolimus combined with reduced tacrolimus proved to be safe within the first month after LT. Future trials may be allowed to implement everolimus early after LT. |
### Instruction:
Is high hemoglobin A1c variability associated with early risk of microalbuminuria in children with T1D?
### Response:
| HbA1c variability is independently associated with development of microalbuminuria in children with T1D, highlighting the importance of maintaining stable glycemic control in pediatric patients. |
### Instruction:
Does dopamine agonist inhibit vascular endothelial growth factor protein production and secretion in granulosa cells?
### Response:
| The effects of D2-ag on VEGF translation and secretion are mediated by D2 signaling pathways that have yet to be described. We found that D2-ag inhibits VEGF secretion at the post-transcriptional level, suggesting that D2-ag treatment should be combined with therapies that inhibit VEGF transcription, such as the employ... |
### Instruction:
Does cepharanthine mitigate pro-inflammatory cytokine response in lung injury induced by hemorrhagic shock/resuscitation in rats?
### Response:
| Cepharanthine significantly mitigates pro-inflammatory cytokine response in acute lung injury induced by HS/RES in rats. The mechanism may involve the HO-1 pathway. |
### Instruction:
Is incomplete response to artificial tears associated with features of neuropathic ocular pain?
### Response:
| Both ocular and systemic (non-ocular) pain complaints are associated with a differential subjective response to artificial tears. |
### Instruction:
Does a mitochondrial DNA mutation influence the apoptotic effect of statins on prostate cancer?
### Response:
| Simvastatin treatment induced apoptosis in human cybrid prostate cancer cells. The response to drug treatments was different depending on mitochondrial genotype. Therefore, the degree to which statins may affect prostate cancer progression may vary based on an individual's mtDNA background. |
### Instruction:
Is aLK alteration a frequent event in aggressive breast cancers?
### Response:
| Immunohistochemical analysis showed ALK is overexpressed in a substantial proportion of breast cancers and possibly plays a significant role in the aggressive behavior of this cancer. Gene amplification is hypothesized to be a possible cause for a significant proportion of this overexpression. Based on these findings, ... |
### Instruction:
Is prohormone convertase 2 activity increased in the hippocampus of Wfs1 knockout mice?
### Response:
| Processing of proSAAS is altered in the hippocampus of Wfs1-KO mice, which is caused by increased activity of PC2. Increased activity of PC2 in Wfs1 KO mice is not caused by alteration in the levels of PC2 protein. Our results suggest a functional link between Wfs1 and PC2. Thus, the detailed molecular mechanism of the... |
### Instruction:
Does economic evaluation of a fall prevention exercise program among people With Parkinson 's disease?
### Response:
| The exercise intervention appeared cost-effective with regard to fall prevention in the whole sample and cost saving in the low disease severity group, when compared with usual care. |
### Instruction:
Is disability associated with nonadherence to diet and fluid restrictions in end-stage renal disease patients undergoing maintenance hemodialysis?
### Response:
| The results of this study showed that the prevalence of nonadherence to diet and fluid restrictions was high in hemodialysis patients. The significant predictors for diet and fluid nonadherence were: older age, high interdialytic weight gain, and severe disability. Medical professionals must be aware of nonadherence an... |
### Instruction:
Does paternal Antisocial Behavior ( But Not Paternal ADHD ) be Associated With Negative Parenting and Child Conduct Problems?
### Response:
| This study suggests that negative parenting may be a potential mechanism by which paternal ASPD is associated with child conduct problems, and demonstrates the importance of considering co-occurring psychopathology in research examining adult ADHD, parenting, and child outcomes. |
### Instruction:
Is coronin 2A ( CRN5 ) expression associated with colorectal adenoma-adenocarcinoma sequence and oncogenic signalling?
### Response:
| We show that increased expression of coronin 2A is associated with the malignant phenotype of human colon carcinoma. Moreover, we linked coronin 2A to MAPK14 and PRMT5 signalling pathways involved in tumour progression. |
### Instruction:
Do ramped hybrid encoding for improved ultrashort echo time imaging?
### Response:
| RHE allows the shortest per-excitation encoding time for ultrashort T2 * imaging, which alleviates the impact of fast T2 * decay occurring during encoding, and enables improved spatial resolution. Magn Reson Med 76:814-825, 2016. © 2015 Wiley Periodicals, Inc. |
### Instruction:
Are natural killer cells polarized toward cytotoxicity in chronic hepatitis C in an interferon-alfa-dependent manner?
### Response:
| Collectively, these results describe a polarized NK cell phenotype induced by chronic exposure to HCV-induced IFN-alfa. This phenotype may contribute to liver injury through TRAIL expression and cytotoxicity, whereas the lacking increase in IFN-gamma production may facilitate the inability to clear HCV. |
### Instruction:
Does stem growth habit affect leaf morphology and gas exchange traits in soybean?
### Response:
| The indeterminate stem growth habit resulted in a greater maximum stomatal conductance for soybean than the determinate habit, and this was attributed to the differences in leaf structure. This raises the further hypothesis that the difference in stem growth habit results in different water use characteristics of soybe... |
### Instruction:
Does lDL lipid apheresis rapidly increase peripheral endothelial progenitor cell competence?
### Response:
| Patients with refractory hyperlipidemia exhibit lower peripheral EPC numbers and a lower proliferative activity of circulating EPCs than healthy controls. A single lipid apheresis treatment significantly stimulates EPC proliferation, it furthermore increases cellular eNOS. In summary, these results show that lipid aphe... |
### Instruction:
Does sevoflurane preconditioning induce rapid ischemic tolerance against spinal cord ischemia/reperfusion through activation of extracellular signal-regulated kinase in rabbits?
### Response:
| This study demonstrates that sevoflurane preconditioning induces rapid tolerance to spinal cord I/R in rabbits, and the tolerance is possibly mediated through the activation of ERK. These data suggest that sevoflurane preconditioning might provide a new practical method for protecting perioperative spinal cord I/R. |
### Instruction:
Does positive end-expiratory pressure improve survival in a rodent model of cardiopulmonary resuscitation using high-dose epinephrine?
### Response:
| In asphyxial cardiac arrest in a small rodent model, continuous application of PEEP (5 cm H(2)O) during and after CPR had beneficial effects on survival that were independent of oxygenation and without adverse cardiovascular effects. |
### Instruction:
Is cCR5Delta32 genotype associated with outcome in type 2 diabetes mellitus?
### Response:
| The presence of CCR5Delta32 is associated with better survival in type 2 diabetes patients. These data suggest that it is worthwhile to explore the protective potential of pharmacological blockade of CCR5 in type 2 diabetic patients. |
### Instruction:
Are chondroitinase ABC and acute electrical stimulation beneficial for muscle reinnervation after sciatic nerve transection in rats?
### Response:
| 150 days after nerve transection, recovery was incomplete with S and F only. Chondroitinase ABC injection at the lesion site and/or 1 hour of electrical stimulation of the proximal nerve stump were beneficial in promoting nerve regeneration and functional muscle reinnervation. |
### Instruction:
Does reduced central tolerance in Omenn syndrome lead to immature self-reactive oligoclonal T cells?
### Response:
| Our findings suggest that T-cell oligoclonal expansion in OS emanates from an incomplete block before the maturation stage of negative selection, which may explain escape of autoreactive T cells from the thymus. Dysregulated genes in patients with OS are closely involved with self-tolerance and autoimmunity. |
### Instruction:
Do inhibition of JNK along with activation of ERK1/2 MAPK pathways improve steatohepatitis among the rats?
### Response:
| These results indicate that the anti-apoptotic effect of T. polium extract is mediated through inhibition of ROS generation. Moreover, the inhibitory effect of T. polium on the development and progression of NASH is apparently governed by the attenuation of JNK activation and augmentation of ERK1/2 activity through pho... |
### Instruction:
Is lDL cholesterol more strongly associated with metabolic syndrome in Japanese women than in men?
### Response:
| LDL cholesterol was more strongly associated with MetS in Japanese women than in men. The correlation between LDL cholesterol and blood pressure was significant in women, but not in men. |
### Instruction:
Is tNF-alpha signaling required for in vivo transcriptional reactivation of latent murine cytomegalovirus?
### Response:
| Our studies show that although TNF-alpha seems to be sufficient, it is not required for initiating transcription of ie gene expression in this model, suggesting that both TNF-alpha-dependent and -independent pathways play an important role in the reactivation of latent CMV infection. |
### Instruction:
Is interaction of Helicobacter pylori with genetic variants in the MDM2 promoter , associated with gastric cancer susceptibility in Chinese patients?
### Response:
| The MDM2 promoter SNP309 is associated with the presence of gastric cancer in Chinese patients especially those with H. pylori infection. |
### Instruction:
Is the lymph node ratio a powerful prognostic factor of node-positive colon cancers undergoing potentially curative surgery?
### Response:
| LNR was a robust prognostic indicator for node-positive colon cancers undergoing curative surgery. Because this ratio-based staging was demonstrated to reduce stage migration and to aid in identifying high-risk patients, it should be proposed as a standard tool for colon cancer staging. |
### Instruction:
Is location of the primary tumor an independent predictor of cancer specific mortality in patients with upper urinary tract urothelial carcinoma?
### Response:
| To our knowledge this is the largest cohort in which the impact of upper urinary tract urothelial carcinoma tumor location on cancer specific mortality was examined. At nephroureterectomy renal pelvis tumors had significantly more advanced T and N stages compared to ureteral tumors. However, after adjustment for stage,... |
### Instruction:
Does acupressure therapy inhibit the development of diabetic complications in Chinese patients with type 2 diabetes?
### Response:
| AT may be an effective nonpharmacological adjunctive strategy for alleviating the development and progression of T2D-related complications. |
### Instruction:
Does the growth rate of large renal masses oppose active surveillance?
### Response:
| The growth rate of large tumours is much higher than of small renal masses and most patients present with advanced disease. Thus, tumours of > or =4 cm seem not to be candidates for active surveillance but require immediate therapy. Further studies are warranted to determine the clinical relevance of progressive tumour... |
### Instruction:
Does stage migration in localized prostate cancer have no effect on the post-radical prostatectomy Kattan nomogram?
### Response:
| These findings show a downward stage migration towards organ-confined disease after the introduction of widespread PSA testing in an Australian cohort. Despite this, the Kattan nomogram remains a robust prognostic tool in clinical practice. |
### Instruction:
Does tempol or candesartan prevent high-fat diet-induced hypertension and renal damage in spontaneously hypertensive rats?
### Response:
| Our study suggests that a high-fat diet induces fatty kidneys, aggravation of blood pressure and renal inflammation in the SHR. Blockade of oxidative stress by tempol or of RAS by candesartan ameliorates the increase in blood pressure and renal inflammation and improves intrarenal lipid accumulation. Therefore, antioxi... |
### Instruction:
Does submaximal exercise coronary artery flow increase in postmenopausal women without coronary artery disease after estrogen and atorvastatin?
### Response:
| In postmenopausal women aged 50 to 65 years without documented coronary artery disease, resting and submaximal exercise-induced coronary artery blood flow improves after receipt of high-dose atorvastatin and conjugated estrogens therapy. |
### Instruction:
Is jak3 involved in dendritic cell maturation and CCR7-dependent migration?
### Response:
| Altogether, our data provide strong evidence that Jak3 is important for DC maturation, migration and function, through a CCR7-mediated signalling pathway. |
### Instruction:
Does [ SKLB-102 inhibit acute hepatitis induced by concanavalin A in mice ]?
### Response:
| SKLB-102 is likely to suppress the occurrence of Con A-induced hepatitis by suppressing macrophages migration and TNF-alpha releases. |
### Instruction:
Are left-sided EEG focus and positive psychiatric family history independent risk factors for affective disorders in temporal lobe epilepsy?
### Response:
| This study points out that a positive family history of psychiatric disorders and interictal EEG epileptiform discharges involving the left temporal lobe are isolated risk factors for affective disorders in TLE. Our results suggest that biological factors are crucial for affective disorders development in TLE. Further ... |
### Instruction:
Is vascular endothelial growth factor-D correlated with hepatic metastasis from gastric cancer after radical gastrectomy?
### Response:
| VEGF-D, which can induce lymphangiogenesis specifically in many kinds of malignant diseases, is an important factor for predicting HM from GC following radical gastrectomy. |
### Instruction:
Are days of delirium associated with 1-year mortality in an older intensive care unit population?
### Response:
| Number of days of ICU delirium was associated with higher 1-year mortality after adjustment for relevant covariates in an older ICU population. Investigations should be undertaken to reduce the number of days of ICU delirium and to study the impact of this reduction on important health outcomes, including mortality and... |
### Instruction:
Is a functional polymorphism in IL-18 associated with severity of bronchial asthma?
### Response:
| Although the association results need to be replicated by other studies, IL-18 variants are significantly associated with asthma severity, and the rs5744247 variant reflects higher transcriptional activity and higher expression of IL-18 in LPS-stimulated monocytes and a higher serum IL-18 level. |
### Instruction:
Is exposure to traffic-related particles and endotoxin during infancy associated with wheezing at age 3 years?
### Response:
| The association between traffic-related particle exposure and persistent wheezing at age 36 months is modified by exposure to endotoxin. This finding supports prior toxicological studies demonstrating a synergistic production of reactive oxygen species after coexposure to diesel exhaust particles and endotoxin. The eff... |
### Instruction:
Does hIV infection affect active case finding of tuberculosis in South African gold miners?
### Response:
| In a population of gold miners who undergo regular radiological screening, the addition of chest radiography to symptom screening substantially improved the sensitivity and positive predictive value. HIV infection did not alter the sensitivity of the screening tool. |
### Instruction:
Does mechanism-anchored profiling derived from epigenetic networks predict outcome in acute lymphoblastic leukemia?
### Response:
| To our knowledge, this is the first method predicting co-expression networks of genes associated with epigenetic mechanisms and to demonstrate its inherent capability to predict therapeutic outcome. This PGnet approach can be applied to any regulatory mechanisms including transcriptional or microRNA regulation in order... |
### Instruction:
Does infection in the intensive care unit alter physiological networks?
### Response:
| Examining the variable pairs with the largest change in correlation across groups reveals potential changes in the way our treatments affect the patient's physiology and in how our bodies react to physiological insults. These findings highlight the usefulness of physiological informatics and suggest new relationships t... |
### Instruction:
Does surgeon-performed fluoroscopy conducted simultaneously during all laparoscopic adjustable gastric band adjustments result in significant alterations in clinical decisions?
### Response:
| Surgeon-performed, real-time, fluoroscopy during LAGB adjustment results in significant changes in clinical care that are not predicted by history and weight loss alone. Routine fluoroscopic imaging altered the course of management in 12% of patients and identified three asymptomatic displaced bands. |
### Instruction:
Is a STAT4 risk allele associated with ischaemic cerebrovascular events and anti-phospholipid antibodies in systemic lupus erythematosus?
### Response:
| Patients with SLE with the STAT4 risk allele had a strikingly increased risk of ICVD, comparable in magnitude to that of hypertension. The results imply that a genetic predisposition is an important and previously unrecognised risk factor for ICVD in SLE, and that aPLs may be one underlying mechanism. |
### Instruction:
Is alcohol consumption associated with high concentrations of urinary hydroxytyrosol?
### Response:
| We report for the first time a direct association between urinary hydroxytyrosol and alcohol consumption at a population level. These findings reinforce previous work in human and animal models that examines wine as a source of hydroxytyrosol and alcohol as an indirect promoter of endogenous hydroxytyrosol generation. ... |
### Instruction:
Are low serum folate and vitamin B-6 associated with an altered cancellous bone structure in humans?
### Response:
| The results of the present study indicate that low serum folate and vitamin B-6 concentrations, but not low serum vitamin B-12 concentrations, are associated with an altered morphology of human bone. |
### Instruction:
Do gamma-amino butyric acid type A receptor mutations at beta2N265 alter etomidate efficacy while preserving basal and agonist-dependent activity?
### Response:
| Mutations at beta2N265 profoundly alter etomidate sensitivity with only small changes in basal and GABA-dependent channel activity. Mutations at the beta2N265 residue or replacement of beta2 with beta1 influence etomidate efficacy much more than binding to inactive receptors. |
### Instruction:
Are uncalibrated stroke volume variations able to predict the hemodynamic effects of positive end-expiratory pressure in patients with acute lung injury or acute respiratory distress syndrome after liver transplantation?
### Response:
| SVV obtained with Vigileo monitor is useful to predict decrease in stroke volume induced by PEEP. Moreover, this device is able to track changes in stroke volume induced by PEEP. |
### Instruction:
Are salivary cortisol responses to mental stress associated with coronary artery calcification in healthy men and women?
### Response:
| In healthy, older participants without history or objective signs of CHD, heightened cortisol reactivity is associated with a greater extent of CAC. These data support the notion that heightened hypothalamic pituitary adrenal activity is a risk factor for CHD. |
### Instruction:
Do relationship between preoperative anxiety and postoperative satisfaction in dental implant surgery with intravenous conscious sedation?
### Response:
| Anxiety was higher in younger patients and women. In this study, a higher preoperative patient anxiety was associated with lower patient satisfaction, but had no influence on postoperative surgeon satisfaction. |
### Instruction:
Does layered implantation of myoblast sheets attenuate adverse cardiac remodeling of the infarcted heart?
### Response:
| Implantation of three- and five-layered myoblast sheets yields favorable results, with better improvement of cardiac function, induction of angiogenesis, more elastic fibers, and less fibrosis. Thus, layered myoblast sheets, in optimal numbers, may attenuate adverse cardiac remodeling of the infarcted heart. |
### Instruction:
Does change in urethral sphincter neuromuscular function during pregnancy persist after delivery?
### Response:
| Urethral sphincter neuromuscular function changed significantly during pregnancy and these changes persisted postpartum. Lack of recovery 6 months' postpartum suggests a physiologic impact of pregnancy itself on future risk of urinary incontinence. |
### Instruction:
Does vascular endothelial growth factor drive autocrine epithelial cell proliferation and survival in chronic rhinosinusitis with nasal polyposis?
### Response:
| These data demonstrate that VEGF is a novel biomarker for chronic rhinosinusitis with hyperplastic sinonasal polyposis that functions in an autocrine feed-forward manner to promote nasal epithelial cell growth and to inhibit apoptosis. These findings implicate a previously unrecognized and novel role of VEGF functionin... |
### Instruction:
Is interferon regulatory factor-1 a key transcription factor in murine beta cells under immune attack?
### Response:
| These data indicate a key regulatory role for IRF-1 in insulin and chemokine secretion by pancreatic islets under inflammatory attack. |
### Instruction:
Do [ Body mass index and diet affect prostate cancer development ]?
### Response:
| A healthy weight and a diet low in total fat, saturated, monounsaturated and polyunsaturated fat and rich in n3 fatty acids, vitamin C and lycopene is associated with a lower risk of CaP. |
### Instruction:
Is tNM stage the most important determinant of survival in metachronous lung cancer?
### Response:
| These data suggest that early tumor stage is the only significant determinant of survival after surgical treatment of metachronous lung cancer. Neither histologic type nor disease-free interval was of prognostic value. Limited resections may be adequate treatment. |
### Instruction:
Does a dopamine transport inhibitor with markedly low abuse liability suppress cocaine self-administration in the rat?
### Response:
| These findings demonstrate essential psychopharmacological differences between AHN-1055 and cocaine and highlight important properties of the analog as a possible pharmacotherapy in cocaine addiction. |
### Instruction:
Is impairment of endogenous melatonin rhythm related to the degree of chronic kidney disease ( CREAM study )?
### Response:
| As melatonin amplitude and melatonin rhythm decreased with advancing renal dysfunction, follow-up research into circadian rhythms in patients with CKD is warranted. |
### Instruction:
Are pre admission antithrombotics associated with improved outcomes following ischaemic stroke : a cohort from the Registry of the Canadian Stroke Network?
### Response:
| Patients with acute ischaemic stroke taking antithrombotic medications at hospital admission have improved functional outcomes. No interaction is noted between use of these medications and outcome following thrombolysis. This large prospective cohort study is consistent with previous published reports, and supports the... |
### Instruction:
Is the haplotype of the MxA gene promoter associated with hepatitis B virus infection in a Chinese population?
### Response:
| This case-control study suggested that the haplotype GA in the MxA gene promoter region would increase the susceptibility to HBV infection in a Chinese population. |
### Instruction:
Is obstructive sleep apnea a risk factor for difficult intubation in morbidly obese patients?
### Response:
| In MO patients undergoing bariatric surgery in the "ramped position," there was no relationship between the presence and severity of OSA, BMI, or NC and difficulty of intubation or laryngoscopy grade. Only a Mallampati score of 3 or 4 or male gender predicted difficult intubation. |
### Instruction:
Does isoflurane inhibit cyclic adenosine monophosphate response element-binding protein phosphorylation and calmodulin translocation to the nucleus of SH-SY5Y cells?
### Response:
| Our data demonstrate that isoflurane inhibits CaM translocation and P-CREB formation. This most likely occurs through isoflurane inhibition of Ca(2+)entry through L-type Ca(2+) channels. |
### Instruction:
Is plasma hepcidin a modest predictor of dietary iron bioavailability in humans , whereas oral iron loading , measured by stable-isotope appearance curves , increases plasma hepcidin?
### Response:
| Plasma hepcidin is only a modest predictor of dietary iron bioavailability in humans. Oral iron loading, measured by stable-isotope appearance curves, increases circulating hepcidin. |
### Instruction:
Does three-dimensional textural analysis of brain images reveal distributed grey-matter abnormalities in schizophrenia?
### Response:
| 3-D TA of brain MR enables detection of subtle distributed morphological features associated with schizophrenia, determined partly by susceptibility genes. |
### Instruction:
Do client-centred home modifications improve daily activity performance of older adults?
### Response:
| Home modification may benefit older adults attempting to age in place. |
### Instruction:
Is apoptosis-associated acetylation on histone H2B an epitope for lupus autoantibodies?
### Response:
| The apoptosis-induced acetylation on H2BK12 is a target for autoantibodies in SLE. Since the anti-H2BK12ac reactivity was mainly found in pre-diseased lupus mice, this epitope seems important in the early phase of the anti-chromatin autoimmune response with subsequent epitope spreading to unmodified H2B. |
### Instruction:
Do [ Summarized real clinical cases use to learn clinical aptitude ]?
### Response:
| the SRCC patients studied from different points of view by the interns included the CSI. Therefore, this action is advisable for the improvement of the patients' clinical approach. |
### Instruction:
Does dissecting the fission yeast regulatory network reveal phase-specific control elements of its cell cycle?
### Response:
| Using a systems-level analysis of the phase-specific nature of the S. pombe cell cycle gene regulation, we have provided new testable evidence for post-transcriptional regulation in the G2 phase of the fission yeast cell cycle. Based on this comprehensive gene regulatory network, we demonstrated how one can generate an... |
### Instruction:
Are antispasmodic and bronchodilator activities of Artemisia vulgaris mediated through dual blockade of muscarinic receptors and calcium influx?
### Response:
| These results indicate that Artemisia vulgaris exhibits combination of anticholinergic and Ca(2+) antagonist mechanisms, which provides pharmacological basis for its folkloric use in the hyperactive gut and airways disorders, such as abdominal colic, diarrhea and asthma. |
### Instruction:
Is perineural invasion an independent predictor of outcome in colorectal cancer?
### Response:
| PNI is grossly underreported in CRC and could serve as an independent prognostic factor of outcomes in these patients. PNI should be considered when stratifying CRC patients for adjuvant treatment. |
### Instruction:
Does helicobacter pylori infection significantly increase insulin resistance in the asymptomatic Japanese population?
### Response:
| Helicobacter pylori infection significantly and independently contributed to promoting insulin resistance in a large asymptomatic population. |
### Instruction:
Is proteinuria reduced by inhibition of inducible nitric oxide synthase in rat renal ischemia-reperfusion injury?
### Response:
| This study suggested possible differences in the mechanism(s) of nephrotoxicity induced by iNOS in the glomeruli and tubular cells. The types of proteins excreted in the urine should be considered in the treatment strategy. In conclusion, this study suggested the involvement of iNOS in IR-induced tubular proteinuria. |
### Instruction:
Does stimulation of sigma-1 receptor signaling by dehydroepiandrosterone ameliorate pressure overload-induced hypertrophy and dysfunctions in ovariectomized rats?
### Response:
| We report, for the first time to our knowledge, the potential role of Sig-1R expression in the heart to attenuate PO-induced hypertrophy in ovariectomized rats. DHEA treatment protects against PO-induced cardiac injury via upregulation of Sig-1R and stimulation of Sig-1R-mediated Akt-eNOS signaling. |
### Instruction:
Is plectin-1 a biomarker of malignant pancreatic intraductal papillary mucinous neoplasms?
### Response:
| Twenty-six of 31 malignant IPMN and all 12 lymph node metastases were Plec-1 positive. In contrast, only one of six benign IPMN expressed Plec-1. The specificity of Plec-1 in distinguishing malignant IPMN from benign IPMN was 83% and its sensitivity 84%. Furthermore, all (four out of four) cyst fluids from malignant IP... |
### Instruction:
Does a novel mutation in GRK1 cause Oguchi disease in a consanguineous Pakistani family?
### Response:
| This is the first report to describe a mutation causing typical Oguchi disease in a large consanguineous Pakistani family. This mutation segregated in eight affected members. |
### Instruction:
Is a haplotype in STAT4 gene associated with rheumatoid arthritis in Caucasians associated in the Han Chinese population , but with the presence of rheumatoid factor?
### Response:
| The STAT4 RA-susceptibility haplotype identified in other previously reported populations has not been replicated in the Han Chinese population with individually matched case-control study design. It is associated only with the presence of RF in the Han Chinese population with RA disease. |
### Instruction:
Does vascular endothelial growth factor inhibit bone morphogenetic protein 2 expression in rat mesenchymal stem cells?
### Response:
| VEGF is a potent inhibitor of BMP2 expression in MSCs, and supplementation or overexpression of VEGF inhibits osteogenesis in vitro and ectopic bone formation in vivo. Strategies to utilize MSCs in bone tissue engineering therefore require careful optimization and precise delivery of growth factors for maximal bone for... |
### Instruction:
Does [ Survivin small interfering RNA suppress the growth of adenoid cystic carcinoma cell xenografts in vivo ]?
### Response:
| Survivin siRNA markedly suppressed the growth of adenoid cystic carcinoma cell xenografts in nude mice through lastingly inhibition effect on Survivin. |
### Instruction:
Does the acyl glucuronide metabolite of mycophenolic acid induce tubulin polymerization in vitro?
### Response:
| MPA and AcMPAG can induce tubulin polymerization in the presence of GTP with AcMPAG being significantly stronger. This property of AcMPAG may contribute to its IMPDH independent antiproliferative effect. |
### Instruction:
Is chelidonium majus hepatotoxic in Wistar rats , in a 4 weeks feeding experiment?
### Response:
| Our study suggests that C. majus, at doses about 50 and 100 times higher than those generally used in humans, does not alter hepatic function. However, the reduction in GSH levels and SOD activity suggests particular attention in use of C. majus or its preparations in situations (pharmacological treatments, physio-path... |
### Instruction:
Do scalp fibroblasts have a shared expression profile in monogenic craniosynostosis?
### Response:
| Common modules of altered gene expression shared by genetically distinct forms of craniosynostosis were identified. Although the expression profiles cannot currently be used to classify individual patients, this may be overcome by using more sensitive assays and sampling additional tissues. |
### Instruction:
Do hounsfield units on computed tomography predict calcium stone subtype composition?
### Response:
| HU measurement of urinary stones on NCCT may be used to separate some calcium stone subtypes, specifically CaOMH and CaODH. This information may be useful in counseling patients on treatment options for patients requiring intervention. |
### Instruction:
Does nitrous oxide-induced analgesia influence nitrous oxide 's immobilizing requirements?
### Response:
| Destroying brainstem noradrenergic neurons or prolonged exposure to N(2)O removes its analgesic effects, but does not change MAC. The immobilizing mechanism of N(2)O is independent from its analgesic effects. |
### Instruction:
Do foxa1 and Foxa2 control the differentiation of goblet and enteroendocrine L- and D-cells in mice?
### Response:
| The winged helix factors Foxa1 and Foxa2 are essential members of the transcription factor network that govern secretory cell differentiation in the mammalian gastrointestinal tract. |
### Instruction:
Do proinflammatory Th2 cytokines induce production of thymic stromal lymphopoietin in human colonic epithelial cells?
### Response:
| Taken together, as in human allergic diseases, an inflammatory Th2 condition in the mucosal lesions of UC patients may trigger increased TSLP expression by IECs, resulting in exacerbation of UC. |
### Instruction:
Is a functional SNP of the Interleukin-18 gene associated with the presence of hepatocellular carcinoma in hepatitis B virus-infected patients?
### Response:
| This study indicates that the -148C, +8925G, and +13925C alleles of the IL-18 gene are associated with the presence of HCC and the 148G>C SNP is functionally important in determining disease outcome. |
### Instruction:
Is estrogen receptor-beta mRNA associated with adverse outcome in patients with breast cancer?
### Response:
| Based on these findings, we conclude that ER-beta may have a different biological role from that of ER-alpha in breast cancer. |
### Instruction:
Is tPH2 a susceptibility gene for suicide in Japanese population?
### Response:
| Our results suggest that the common SNPs and haplotypes of the TPH2 gene are unlikely to contribute to the genetic susceptibility to suicidal behavior in Japanese population. |
### Instruction:
Does failure to ferment dietary resistant starch in specific mouse models of obesity result in no body fat loss?
### Response:
| (1) decreased body fat by RS is not simply due to dietary energy dilution in C57Bl/6J mice, and (2) along with their inability to ferment RS, RS fed obese mice did not lose body fat. Thus, colonic fermentation of RS might play an important role in the effect of RS on fat loss. |
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