question stringlengths 52 373 | long_answer stringlengths 1 3.34k |
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### Instruction:
Is serum aminotransferase ratio independently correlated with hepatosteatosis in patients with HCV : a cross-sectional observational study?
### Response:
| The ALT/AST ratio could be a strong risk of hepatosteatosis in patients with chronic HCV infection. |
### Instruction:
Does bluetongue virus infection create light averse Culicoides vectors and serious errors in transmission risk estimates?
### Response:
| Because the majority of global vector surveillance for bluetongue uses only light-trapping, transmission risk estimates based on these collections are likely severely understated. Where national surveillance programs exist, alternatives to light-trapping should be considered. More broadly, disseminated infections of ma... |
### Instruction:
Does early immunosuppression treatment correlate with later de novo donor-specific antibody development after kidney and pancreas transplantation?
### Response:
| The risk of post-transplant dnDSA development correlates with early immunosuppressive management. |
### Instruction:
Does transplacental Administration of Rosiglitazone attenuate Hyperoxic Lung Injury in a Preterm Rabbit Model?
### Response:
| In a preterm rabbit model, prenatal maternal administration of rosiglitazone attenuates neonatal hyperoxic lung injury and results in a more mature pulmonary parenchyma. |
### Instruction:
Does leukocyte function-associated antigen-1 deficiency impair responses to polymicrobial sepsis?
### Response:
| LFA-1 deficiency did not attenuate neutrophil recruitment to various organs to adequately mitigate secondary tissue injury in sepsis. It was associated with decreased neutrophil recruitment to the abdominal cavity, higher bacterial load, leading to increased mortality in an abdominal, polymicrobial sepsis. |
### Instruction:
Does a Novel Collagen Matricryptin reduce Left Ventricular Dilation Post-Myocardial Infarction by Promoting Scar Formation and Angiogenesis?
### Response:
| Collagen Iα1 matricryptin p1158/59 facilitates LV remodeling post-MI by regulating scar formation through targeted ECM generation and stimulation of angiogenesis. |
### Instruction:
Does early hospital readmission for gastrointestinal-related complications predict long-term mortality after pancreatectomy?
### Response:
| In addition to known risk factors, 30-day readmission for gastrointestinal-related complications following pancreatectomy independently predicts increased mortality. Additional studies are necessary to identify surgical, medical, and social factors contributing to EHR, as well as interventions aimed at decreasing postp... |
### Instruction:
Is undiagnosed diabetes prevalent in younger adults and associated with a higher risk cardiometabolic profile compared to diagnosed diabetes?
### Response:
| People with undiagnosed diabetes have a higher predicted risk for cardiovascular disease compared to those with diagnosed diabetes. Intensive screening for diabetes in younger adults should be stressed in public healthcare to reduce the burden of modifiable cardiometabolic risk among individuals with undiagnosed diabet... |
### Instruction:
Does iGFBP-1 predict all-cause mortality in elderly women independently of IGF-I?
### Response:
| High and low serum insulin-like IGFBP-1 levels were associated with an increased risk of all-cause mortality in elderly women, compared to moderate levels. |
### Instruction:
Are olfactory bulb and olfactory sulcus depths associated with disease duration and attack frequency in multiple sclerosis patients?
### Response:
| The OB and OSD were atrophied significantly in patients with MS, and this was correlated with disease duration and attack frequency. The left side tended to be dominant. |
### Instruction:
Is intracortical inhibition abnormality during the remission phase of multiple sclerosis related to upper limb dexterity and lesions?
### Response:
| High intracortical inhibition possibly contributes to (or prevents remission from) motor impairment. Lesions may be associated with intracortical inhibition shifts. |
### Instruction:
Do baicalein protect pancreatic injury in rats with severe acute pancreatitis by inhibiting pro-inflammatory cytokines expression?
### Response:
| Baicalein demonstrated a well curative capability on rats with SAP. The mechanism may be alleviateing pancreatic injury and inhibiting pro-inflammatory cytokines expression. |
### Instruction:
Does effectiveness of skeleton handouts during ophthalmology theory lecture for undergraduate medical students?
### Response:
| The student can improve their performance during examination while working on skeletal handouts during theory lectures in spite of showing a preference for complete handouts. |
### Instruction:
Does gene Expression of FRAS1-Related Extracellular Matrix 1 be Decreased in Nitrofen-Induced Congenital Diaphragmatic Hernia?
### Response:
| Decreased expression of FREM1 in the nitrofen-induced CDH model may disturb the formation of the diaphragmatic mesenchyme, thus contributing to the development of diaphragmatic defects. |
### Instruction:
Does huntingtin exist as Multiple Splice Forms in Human Brain?
### Response:
| The identification of novel HTT transcripts has implications for HTT protein isoform expression and function. Understanding the functional significance of HTT alternative splicing would be critical to guide the design of potential therapeutics in HD that aim to reduce the toxic HTT transcript or protein product includi... |
### Instruction:
Is antidopaminergic Medication Associated with More Rapidly Progressive Huntington 's Disease?
### Response:
| The results from this analysis suggest ADM treatment is associated with more advanced and rapidly progressing HD although whether these drugs are causative in driving this progression requires further, prospective studies. |
### Instruction:
Does methylene Blue Partially rescue Heart Defects in a Drosophila Model of Huntington 's Disease?
### Response:
| Our data suggest that improvement of mitochondrial function by MB, or related compounds, could be an efficient therapeutic strategy to prevent cardiac failure in HD patients. |
### Instruction:
Does environmental enrichment induce early heroin abstinence in an animal conflict model?
### Response:
| EE facilitated abstinence in the conflict model. The current use of the abstinence-conflict model to investigate EE as a behavioral strategy to facilitate abstinence will help in the development of effective treatments for human addicts by bringing together the positive consequences of abstinent behavior in an enriched... |
### Instruction:
Does the ubiquitin ligase Siah2 regulate obesity-induced adipose tissue inflammation?
### Response:
| Siah2 links adipocyte hypertrophy with adipocyte dysfunction and recruitment of proinflammatory immune cells to adipose tissue. Selective regulation of PPARγ activity is a Siah2-mediated mechanism contributing to obesity-induced adipose tissue inflammation. |
### Instruction:
Is behr 's Syndrome Typically Associated with Disturbed Mitochondrial Translation and Mutations in?
### Response:
| We think that |
### Instruction:
Do 11-β hydroxysteroid type 1 knockout mice display an antidepressant-like phenotype in the forced swim test?
### Response:
| Taken together these results suggest that 11β-HSD1 may play an important role in depression-related behaviours and further studies are necessary to fully characterise its role in such behaviour. |
### Instruction:
Does feeding of Whitefly on Tobacco decrease Aphid Performance via Increased Salicylate Signaling?
### Response:
| In conclusion, these results underscore the important role that induction of the SA signaling pathway by B. tabaci nymphs plays in defeating aphids. It also indicates that the activity of β-1, 3-glucanase and chitinase may be positively correlated with resistance to aphids. |
### Instruction:
Is the development of depression-like behavior consolidated by IL-6-induced activation of locus coeruleus neurons and IL-1β-induced elevated leptin levels in mice?
### Response:
| These results suggest that IL-6-dependent LC neuronal activation induced depression-like behavior and IL-1β-induced increase in leptin levels enhanced α1-adrenoceptor-mediated depression-like behavior. |
### Instruction:
Do lPS-preconditioned mesenchymal stromal cells modify macrophage polarization for resolution of chronic inflammation via exosome-shuttled let-7b?
### Response:
| LPS pre-Exo may have improved regulatory abilities for macrophage polarization and resolution of chronic inflammation by shuttling let-7b, and these exosomes carry much immunotherapeutic potential for wound healing. |
### Instruction:
Does chronic oxycodone induce integrated stress response in rat brain?
### Response:
| The combined in vivo and in vitro data suggest that prolonged opioid treatment induces the integrated stress response in the central nervous system; it modulates translational machinery in favor of specific mRNA and this may contribute to the drug-induced changes in neuronal plasticity. |
### Instruction:
Do neuroinflammatory signals enhance the immunomodulatory and neuroprotective properties of multipotent adult progenitor cells?
### Response:
| Rat MAPC possess immune modulatory and neuroprotective properties which are enhanced in response to neuroinflammatory signals. These findings thereby warrant further research to evaluate MAPC transplantation as a therapeutic approach in diseases with an immunological and neurodegenerative component such as multiple scl... |
### Instruction:
Does pIWIL2 promote progression of non-small cell lung cancer by inducing CDK2 and Cyclin A expression?
### Response:
| Our findings shed light on the function of PIWIL2 in NSCLC and suggest potential prognostic and therapeutic value. |
### Instruction:
Does low-intensity Pulsed Ultrasound improve Erectile Function in Streptozotocin-induced Type I Diabetic Rats?
### Response:
| LIPUS therapy improved erectile function and reversed pathologic changes in penile tissue of STZ-induced diabetic rats. LIPUS therapy has potential as a noninvasive therapy for diabetic ED in the clinic. |
### Instruction:
Does vascular Smooth Muscle Sirtuin-1 protect Against Aortic Dissection During Angiotensin II-Induced Hypertension?
### Response:
| Endogenous SirT1 in aortic smooth muscle is required to maintain the structural integrity of the aortic wall in response to oxidant and inflammatory stimuli, at least in part, by suppressing oxidant-induced matrix metalloproteinase activity. SirT1 activators could potentially be a novel therapeutic approach to prevent ... |
### Instruction:
Does topical concentrated epinephrine ( 1:1000 ) cause acute cardiovascular changes during endoscopic sinus surgery?
### Response:
| Combination topical (1:1000 to 1:2000) and injectable (1:100,000) epinephrine is safe for use in endoscopic sinonasal surgery. Injection resulted in the cardiovascular changes and accounted for the cardiovascular events reported. |
### Instruction:
Does hTERT promote the invasion of gastric cancer cells by enhancing FOXO3a ubiquitination and subsequent ITGB1 upregulation?
### Response:
| The hTERT/MDM2-FOXO3a-ITGB1 pathway markedly contributes to hTERT-promoted gastric cancer invasion, suggesting that this pathway might be a novel target for the prevention and treatment of gastric cancer metastasis. |
### Instruction:
Does circulating interleukin-1β promote endoplasmic reticulum stress-induced myocytes apoptosis in diabetic cardiomyopathy via interleukin-1 receptor-associated kinase-2?
### Response:
| Elevated circulating IL-1β contributed to promote ER stress- induced myocytes apoptosis by affecting IRAK-2/CHOP pathway in DCM. |
### Instruction:
Is elevated free fatty acid level a risk factor for early postoperative hypoxemia after on-pump coronary artery bypass grafting : association with endothelial activation?
### Response:
| Elevated FFA concentration is a risk factor for early postoperative hypoxemia after on-pump CABG, which may be closely associated with endothelial activation. |
### Instruction:
Does trefoil factor 1 expression suppress Helicobacter pylori-induced inflammation in gastric carcinogenesis?
### Response:
| These findings underscore an important protective role of TFF1 in abrogating H. pylori-mediated inflammation, a crucial hallmark of gastric tumorigenesis. Therefore, loss of TFF1 expression could be an important step in H. pylori-mediated gastric carcinogenesis. |
### Instruction:
Do bombesin-conjugated nanoparticles improve the cytotoxic efficacy of docetaxel against gastrin-releasing but androgen-independent prostate cancer?
### Response:
| This study provides an alternate approach for polysorbate-free delivery of DTX, with improved in vivo performance. |
### Instruction:
Does quantitative Analysis of Fundus-Image Sequences reveal Phase of Spontaneous Venous Pulsations?
### Response:
| The heterogeneity in waveforms and arteriovenous phases suggests that the mechanism governing the venous outflow resistance differs among healthy subjects. |
### Instruction:
Do p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb?
### Response:
| This study establishes that loss of p53 function decreases lysosomal TSC2 and increases lysosomal Rheb resulting in hyperactive mTORC1, findings that are consistent with a more malignant phenotype. |
### Instruction:
Does ketorolac reduce effectiveness of pleurodesis in pediatric patients with spontaneous pneumothorax?
### Response:
| Despite the intrinsic antiinflammatory properties of ketorolac, our data suggests that its use for patients undergoing pleurodesis for spontaneous pneumothorax does not detrimentally influence the outcomes of surgery. Therefore, we conclude that ketorolac can be used for pain control in this population. Large-scale stu... |
### Instruction:
Does whole-body MRI of patients with polymyalgia rheumatica identify a distinct subset with complete patient-reported response to glucocorticoids?
### Response:
| A subset of patients with rheumatologist-diagnosed PMR had a characteristic, extracapsular pattern of MRI inflammation, associated with elevated IL-6/CRP and with complete patient-reported glucocorticoid responsiveness. |
### Instruction:
Does a geometrical shift result in erroneous appearance of low frequency tissue eddy current induced phase maps?
### Response:
| The conductivity scaling of LF phase maps is attributable to the RF phase leakage, thus dependent on the RF conductivity. In fact, simulations show that the LF phase is not measurable. Magn Reson Med 76:905-912, 2016. © 2015 Wiley Periodicals, Inc. |
### Instruction:
Does methylphenidate increase glucose uptake in the brain of young and adult rats?
### Response:
| These findings indicate that MPH increases glucose consumption in the brain, and that these changes are dependent on age and posology. |
### Instruction:
Is hypervolemic hypernatremia the most common type of hypernatremia in the intensive care unit?
### Response:
| Hypervolemic hypernatremia is by far the most common cause of hypernatremia in patients in the intensive care unit. Even though the patients are in negative fluid balance at the time of the development of the hypernatremia, earlier saline administration has caused massive volume overload despite the ongoing losses. Pos... |
### Instruction:
Is vasopressor use as a surrogate for post-intubation hemodynamic instability associated with in-hospital and 90-day mortality : a retrospective cohort study?
### Response:
| Emergently intubated patients manifesting hemodynamic instability after but not before intubation, as measured by vasoactive administration 60 min post-intubation, have a higher association with in-hospital and 90-day mortality. |
### Instruction:
Does increasing proline and myo-inositol improve tolerance of Saccharomyces cerevisiae to the mixture of multiple lignocellulose-derived inhibitors?
### Response:
| Increasing proline and myo-inositol were uncovered as the new determinants for improving strain tolerance to FAP under the guidance of metabolomics. Meanwhile, this study displayed the powerful application of metabolomics to develop rational strategies to increase stress tolerance and provided valuable insights into th... |
### Instruction:
Does vitamin C prevent the endothelial dysfunction induced by acute ethanol intake?
### Response:
| Our study provides novel evidence that vitamin C prevents the endothelial dysfunction induced by acute ethanol intake by a mechanism that involves reduced ROS generation and increased NO availability in endothelial cells. |
### Instruction:
Does dexamethasone protect Against Apoptotic Cell Death of Cisplatin-exposed Auditory Hair Cells In Vitro?
### Response:
| DXM protects against cisplatin-induced loss of OHCs in the basal turn of rat OC explants as demonstrated by reductions in oxidative stress and NOX-3 production and decreased levels of apoptotic cell death. |
### Instruction:
Are genotype 3 and higher low-density lipoprotein levels predictors of good response to treatment of recurrent hepatitis C following living donor liver transplantation?
### Response:
| Genotype 3 and higher LDL levels predict SVR in patients treated for hepatitis C recurrence following LDLT, whereas absence of RVR and EVR strongly predict treatment failure. |
### Instruction:
Do obesity and Hyperlipidemia Modulate Alveolar Bone Loss in Wistar Rats?
### Response:
| Obesity and hyperlipidemia modulate the host response to challenges in the periodontium, increasing the expression of periodontal breakdown. |
### Instruction:
Is human endogenous retrovirus HERV-K ( HML-2 ) activity in prostate cancer dominated by a few loci?
### Response:
| Our findings further underline that HML-2 expression is commonly highly tissue-specific. In prostate cancer, a limited number of loci become activated, especially H22q and ERVK-5. As expressed and non-expressed proviruses do not differ significantly in TFBS, tissue- and tumor-specific expression may be governed primari... |
### Instruction:
Does estrogen administered after cardiac arrest and cardiopulmonary resuscitation ameliorate acute kidney injury in a sex- and age-specific manner?
### Response:
| Estrogen administration after resuscitation from CA ameliorates renal injury in young males and aged mice in both sexes. Because injury was small, young females were not affected. The protective effect of exogenous estrogen may be detectable with loss of endogenous estrogen in aged females and could be mediated by diff... |
### Instruction:
Does phosphoproteomic analysis reveal Smarcb1 dependent EGFR signaling in Malignant Rhabdoid tumor cells?
### Response:
| These results support recent findings regarding the effectivity of EGFR inhibitors in hindering the proliferation of human MRT cells and demonstrate that activation of EGFR signaling in Rhabdoid tumors is SMARCB1 dependent. |
### Instruction:
Is plasma myostatin only a weak predictor for weight maintenance in obese adults?
### Response:
| Plasma myostatin might be suitable in predicting weight regain after marked weight loss, but no association with weight loss was observed in patients undergoing a non-surgical weight loss program. Therefore, myostatin does not seem to be a predictor for success in non-surgical weight loss approaches. |
### Instruction:
Are iFRD1 gene polymorphisms associated with nasal polyposis in cystic fibrosis patients?
### Response:
| These results showed the association of the IFRD1-rs7817 polymorphism with NP in CF patients. |
### Instruction:
Does increased tumour ADC value during chemotherapy predict improved survival in unresectable pancreatic cancer?
### Response:
| Relative changes in sADC could provide a useful imaging biomarker to predict PFS and OS with chemotherapy for unresectable pancreatic adenocarcinoma. |
### Instruction:
Does severity of Depression predict Remission Rates Using Transcranial Magnetic Stimulation?
### Response:
| Patients with a baseline level of depression characterized as mild or moderate had significantly better outcomes following rTMS compared to patients with severe depression. |
### Instruction:
Does cEVL e-learning teach GUMS method to `` score '' hypospadias preoperatively and predict postoperative outcomes?
### Response:
| We show that CEVL e-learning is an effective tool, which requires a minimal time investment, for teaching GUMS scoring. We believe that e-learning is a good platform to promote uniform clinical practices in outcomes research and for resident training. |
### Instruction:
Does cdk5 regulate developmental remodeling of mushroom body neurons in Drosophila?
### Response:
| These data show that Cdk5 regulates the onset and extent of remodeling of the Drosophila MB. Given the wide phylogenetic conservation of Cdk5, we suggest that it is likely to play a role in developmental remodeling in other systems, as well. Moreover, we speculate that the well-established role of Cdk5 in neurodegenera... |
### Instruction:
Does the pregnant mouse uterus exhibit a functional kisspeptin/KISS1R signaling system on the day of embryo implantation?
### Response:
| These results lead us to conclude that on D4 of pregnancy, the mouse uterus expresses a functional KP/KISS1R signaling system strengthening the possibility that this signaling system regulates embryo implantation. These findings strengthen the rationale for determining whether such a functional system exists in the ute... |
### Instruction:
Does maternal pain influence her evaluation of recurrent pain in 6- to 11-year-old healthy children?
### Response:
| Maternal health factors may influence her evaluation of her child's pain. Family health and pain behaviour should be considered when recurrent pain is suspected in a child. |
### Instruction:
Is genetic variant of Interleukin-18 gene associated with the Frailty Index in the English Longitudinal Study of Ageing?
### Response:
| We show potential associations between genetic variants of four genes and the frailty index. These genes are involved in the cholesterol transport and inflammatory pathway and, as such, our results provide further support for the involvement of the immunological processes in frailty of the elderly. |
### Instruction:
Are painful and multiple anogenital lesions common in men with Treponema pallidum PCR-positive primary syphilis without herpes simplex virus coinfection : a cross-sectional clinic-based study?
### Response:
| Primary syphilis lesions are often painful and/or multiple in the absence of herpes coinfection, and may be clinically misdiagnosed. |
### Instruction:
Is greater temperature variability associated with a worse neurological outcome after cardiac arrest?
### Response:
| Among comatose survivors treated with TTM after CA, 25% of patients had high TV; however, this was not associated with a worse neurologic outcome. |
### Instruction:
Is family history of skin cancer associated with early-onset basal cell carcinoma independent of MC1R genotype?
### Response:
| Risk for BCC varied based upon the type and age of onset of skin cancer among affected relatives; individuals with a first-degree relative diagnosed with skin cancer prior to age 50 were at highest risk for BCC (OR 4.79, 95% CI 2.90-7.90). Even after taking into account potential confounding effects of MC1R genotype an... |
### Instruction:
Do fanconi anemia cells with unrepaired DNA damage activate components of the checkpoint recovery process?
### Response:
| Our results show that FA cells, despite extensive DNA damage, do not loss the capacity to express the transcriptional and protein components of checkpoint recovery that might eventually allow their division with unrepaired DNA damage. This might allow cell survival but increases the genomic instability inherent to FA i... |
### Instruction:
Does platelet-derived Growth Factor-B protect Rat Cardiac Allografts From Ischemia-reperfusion Injury?
### Response:
| Our results suggest that PDGF-B signaling may play a role in endothelial and cardiomyocyte recovery from IRI after heart transplantation. |
### Instruction:
Is reflectance confocal microscopy a useful non-invasive tool in the in vivo diagnosis of pigmented basal cell carcinoma in Asians?
### Response:
| This case series shows the value of non-invasive in vivo RCM imaging in the differentiation of malignant and benign pigmented lesions. Early diagnosis of small, pigmented BCC allows earlier excision with better prognosis. Future biopsies of benign lesions in cosmetic areas could also be avoided. |
### Instruction:
Do neuromagnetic high-frequency oscillations correlate with seizure severity in absence epilepsy?
### Response:
| CAE has focal neuromagnetic sources. The transition from interictal to ictal periods is associated with the elevation of low-frequency brain activities. The strength of HFOs reflects the severity of absence seizures. |
### Instruction:
Is a novel self-propelled disposable colonoscope effective for colonoscopy in humans ( with video )?
### Response:
| SPDC was highly successful, simple to use, and safe in achieving complete colonoscopy (cecal intubation). ( |
### Instruction:
Are methods to place a value on additional evidence illustrated using a case study of corticosteroids after traumatic brain injury?
### Response:
| VOI analysis can be integrated with the results of meta-analysis to help inform whether a particular research proposal is potentially worthwhile and whether it should be prioritized over other research topics that could be commissioned with the same resources. |
### Instruction:
Does a Modification to the McHale Procedure reduce Operative Time and Blood Loss?
### Response:
| The modified McHale technique is faster with otherwise equivocal results in the immediate operative periods. There is less heterotopic bone formation but more proximal femoral migration with this new technique. |
### Instruction:
Does l-Dopa stimulate Cortisol Secretion through Adrenocorticotropic Hormone Release in Short Children?
### Response:
| Our data suggest a stimulatory effect of the dopaminergic system on the hypothalamic-pituitary-adrenal axis. |
### Instruction:
Does loss of 5-lipoxygenase activity protect mice against paracetamol-induced liver toxicity?
### Response:
| The activity of 5-LO may play a critical role in paracetamol-induced hepatic toxicity by regulating paracetamol metabolism and oxidative stress. |
### Instruction:
Is reduced expression of membrane-bound ( m ) RAGE a biomarker of multiple sclerosis disease progression?
### Response:
| The reduced mRAGE expression on PBMCs in general, and on monocytes in particular, can be used as biomarker of MS disease severity and progression. |
### Instruction:
Does use of a novel polyp `` ruler snare '' improve estimation of colon polyp size?
### Response:
| The modified ruler snare improved polyp size assessment compared with a standard snare, particularly with large polyps. Overall, although size estimation continues to be imprecise, the addition of calibrated markings to a polypectomy snare is a simple and likely low-cost means to improve neoplasia surveillance recommen... |
### Instruction:
Is the Gene Polymorphism of IL-17 G-152A Associated with Increased Colonization of Streptococcus pneumoniae in Young Finnish Children?
### Response:
| Our results indicate that IL-17 G-152A is associated with increased colonization rate of S. pneumoniae in young children, suggesting that IL-17A plays an important role in protection against pneumococcal colonization. |
### Instruction:
Does fish consumption do n't reduce the risk of hepatocellular carcinoma?
### Response:
| In conclusion, our results do not support a significant inverse association of fish consumption with HCC risk. More in-depth studies are warranted to report more detailed results, including stratified results by fish types, preparation methods, and gender. |
### Instruction:
Is aldehyde dehydrogenase 2 ( ALDH2 ) Glu504Lys polymorphism associated with hypertension risk in Asians : a meta-analysis?
### Response:
| This meta-analysis suggested that ALDH2 Glu504Lys polymorphism was a risk factor of hypertension in Asians. |
### Instruction:
Does calcitriol significantly enhance the efficacy of radiation of human cervical tumors in mice?
### Response:
| Calcitriol had anti-tumoral activity, but failed to enhance the efficacy of radiation in human cervical cancers. |
### Instruction:
Are atrophy and lower regional perfusion of temporo-parietal brain areas correlated with impairment in memory performances and increase of EEG upper alpha power in prodromal Alzheimer 's disease?
### Response:
| High EEG upper/low alpha power ratio was associated with cortical thinning lower perfusion in temporo-parietal. Moreover, atrophy and lower perfusional rate were both significantly correlated with memory impairment in MCI subjects. The increase of EEG upper/low alpha frequency power ratio could be useful for identifyin... |
### Instruction:
Is reduced INF2 expression in nephrotic syndrome possibly related to clinical severity of steroid resistance in children?
### Response:
| We propose that examination of INF2 expression may help to differentiate MCD from FSGS and evaluate the clinical severity of SRNS in children. |
### Instruction:
Is the Knowledge of the Physicians about Sepsis Bundles Suboptimal : A Multicenter Survey?
### Response:
| The knowledge of the sepsis bundles of the physicians, who are in charge of sepsis patients in routine work, was suboptimal. Most of the participants were unaware of SSC and new bundles. Training of the physicians of all centers about sepsis bundles is suggested according to these results. |
### Instruction:
Does overexpression of forkhead box protein M1 ( FOXM1 ) play a critical role in colorectal cancer?
### Response:
| Our data suggest that the pathogenesis of CRC maybe mediated by FOXM1, and FOXM1 could represent selective targets for the molecularly targeted treatments of CRC. |
### Instruction:
Does ribavirin concentration determine treatment success of first-generation DAA-based chronic HCV therapy?
### Response:
| We established the therapeutic range for ribavirin in boceprevir- and telaprevir-based therapy that balances safety and efficacy. |
### Instruction:
Does nongrafted Skin Area Best predict Exercise Core Temperature Responses in Burned Humans?
### Response:
| These data imply that individuals with grafted skin have greater increases in core temperature when exercising in the heat and that the magnitude of this increase is best explained by the amount of nongrafted skin available for heat dissipation. |
### Instruction:
Does combined Training reduce Subclinical Inflammation in Obese Middle-Age Men?
### Response:
| Twenty-four weeks of moderate- to high-intensity CT reduced markers of subclinical inflammation associated with obesity and improved insulin resistance and functional capabilities of obese middle-age men, regardless of dietary intervention and weight loss. |
### Instruction:
Are early trends in serum phosphate and creatinine levels associated with mortality following major hepatectomy?
### Response:
| Early trends in creatinine and phosphate (between the day of surgery and PoD 1) identify patients at risk for PHLF and mortality. |
### Instruction:
Does rNA-seq analysis of Pichia anomala reveal important mechanisms required for survival at low pH?
### Response:
| Our findings provide insight into the molecular and genetic basis of low pH tolerance in P. anomala which was previously unknown. Ultimately, this is a step towards developing non-conventional yeasts such as P. anomala for the production of industrially relevant chemicals under low pH conditions. |
### Instruction:
Is the dolutegravir R263K resistance mutation in HIV-1 integrase incompatible with the emergence of resistance against raltegravir?
### Response:
| The DTG-resistant R263K substitution antagonized the development of HIV-1 resistance against RAL while partially facilitating the occurrence of resistance against EVG. |
### Instruction:
Do adipogenic progenitors from obese human skeletal muscle give rise to functional white adipocytes that contribute to insulin resistance?
### Response:
| Using in-vitro models, we show for the first time that secretions of skeletal muscle adipocytes are able to impair insulin action and signaling of muscle fibers. This paracrine effect could explain, at least in part, the negative association between high levels of IMAT and insulin sensitivity in obesity and aging. |
### Instruction:
Is concomitant Gleason Score ≥ 7 prostate cancer an independent prognosticator for poor survival in nonmetastatic bladder cancer patients undergoing radical cystoprostatectomy?
### Response:
| Concomitant PCa in RCPx specimen of BCa patients is a common finding. The incidence of concomitant PCa has significantly increased within 2 decades, presenting a more aggressive phenotype. Age and in particular concomitant GS ≥7 PCa are independent prognosticators for poor survival in patients with nonmetastatic organ-... |
### Instruction:
Does subclinical Atherosclerosis be Inversely Associated With Gray Matter Volume in African Americans With Type 2 Diabetes?
### Response:
| Subclinical atherosclerosis was associated with smaller GMV and poorer cognitive performance in African Americans with diabetes. Cardioprotective strategies could preserve GMV and cognitive function in high-risk African Americans with diabetes. |
### Instruction:
Does proliferation Index predict Survival after Second Craniotomy within 6 Months of Adjuvant Radiotherapy for High-grade Glioma?
### Response:
| The presence of residual tumour at repeat craniotomy within 6 months of radiotherapy is not an independent indicator of prognosis. Patients with residual tumour that had a low Ki67 had a similar median survival as those with only treatment necrosis. Reduced proliferation of residual tumour cells and widespread necrosis... |
### Instruction:
Are outcomes in endocrine cancer surgery affected by racial , economic , and healthcare system demographics?
### Response:
| The surgeon's volume and the patient's living conditions are crucial and independent factors in multiple aspects of endocrine cancer management. |
### Instruction:
Is quality of life in preoperative patients with sacroiliac joint dysfunction at least as depressed as in other lumbar spinal conditions?
### Response:
| Patients with SIJ dysfunction considering surgery have decrements in quality of life as or more severe compared to patients with degenerative spondylolisthesis, spinal stenosis, and intervertebral disc herniation. |
### Instruction:
Is genetic control of pear rootstock-induced dwarfing and precocity linked to a chromosomal region syntenic to the apple Dw1 loci?
### Response:
| We report the first QTLs associated with vigour control and flowering traits in pear rootstocks. Orthologous loci were found to control scion growth and precocity in apple and pear rootstocks. The application of our results may assist in the breeding process of a pear rootstock that confers both vigour control and prec... |
### Instruction:
Does bridging therapy for oral anticoagulation increase the risk for bleeding-related complications in total joint arthroplasty?
### Response:
| In this study, there was a significant increase in bleeding-related complications in total joint replacement with bridging therapy compared to prophylaxis. This risk was highest in patients with total hip arthroplasty. There were no thromboembolic events in bridged patients. |
### Instruction:
Does taurine regulate Mitochondrial Function During 7,12-Dimethyl Benz [ a ] anthracene Induced Experimental Mammary Carcinogenesis?
### Response:
| The results of our present study demonstrated the chemotherapeutic efficacy of taurine treatment for DMBA-induced breast carcinomas. |
### Instruction:
Do mutational landscapes of tongue carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance?
### Response:
| Our study defines the Asian OTSCC mutational landscape, highlighting the key role of Notch signaling in oral tongue tumorigenesis. We also observed somatic mutations in multiple therapeutically relevant genes, which may represent candidate drug targets in this highly lethal tumor type. |
### Instruction:
Does novel X-ray image noise reduction technology reduce patient radiation dose while maintaining image quality in coronary angiography?
### Response:
| This study demonstrates that the novel X-ray imaging technology provides non-inferior image quality compared with conventional angiographic systems for interventional cardiology with a 53 % patient dose reduction. |
### Instruction:
Does helicobacter pylori HP0425 target the Nucleus with DNase I-Like Activity?
### Response:
| These results suggest that HP0425 carrying a nuclear localization signal sequence translocates into the nucleus of host cells and degrades genomic DNA by DNase I-like enzymatic activity, which is a new pathogenic strategy of H. pylori in the host. |
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