question stringlengths 52 373 | long_answer stringlengths 1 3.34k |
|---|---|
### Instruction:
Is short-term follow-up in 6 months unnecessary for asymptomatic breast lesions with benign concordant results obtained at ultrasonography-guided 14-gauge core needle biopsy?
### Response:
| Short-term follow-up in 6 months is unnecessary for asymptomatic benign concordant breast lesions at ultrasonography-guided CNB. |
### Instruction:
Does magnetic resonance neurography detect diabetic neuropathy early and with Proximal Predominance?
### Response:
| In DPN, the predominant site of microstructural nerve alteration is at the thigh level with a strong proximal-to-distal gradient. Nerve proton spin density at the thigh level is a novel quantitative imaging biomarker of early DPN and increases with neuropathy severity. |
### Instruction:
Is economic inequality related to cross-national prevalence of psychotic symptoms?
### Response:
| Although the cross-sectional design limits ability to claim causality, income inequality appears important for understanding psychotic symptoms. |
### Instruction:
Does uridine supplementation exert anti-inflammatory and anti-fibrotic effects in an animal model of pulmonary fibrosis?
### Response:
| In summary, we were able to show that uridine has potent anti-inflammatory and anti-fibrotic properties. As uridine supplementation has been shown to be well tolerated and safe in humans, this might be a new therapeutic approach for the treatment of fibrotic lung diseases. |
### Instruction:
Does comparison of two types of proximal femoral hail in the treatment of intertrochanteric femur fractures?
### Response:
| In the treatment of ITF, PFNs with an integrated, interlocking, compression lag screw, or two separate lag screws did not differ in terms of functional and radiological results or complication rate. |
### Instruction:
Does dickkopf-1 promote the differentiation and adipocytokines secretion via canonical Wnt signaling pathway in primary cultured human preadipocytes?
### Response:
| Our results suggest that rhDKK-1 could promote ASCs differentiation and increase adipocytokines secretion via canonical Wnt signaling pathway. |
### Instruction:
Is increased pulsatility in the fetal ductus venosus related to altered cardiac strain in high-risk pregnancies?
### Response:
| Increased venous pulsatility was not related to fetal cardiac strain. This might indicate that the DVs does not primarily open due to increased central venous pressure and that cardiac strain is affected late in the process of moderate fetal hypoxia. |
### Instruction:
Are plasma uric acid concentrations reduced by fenofibrate : A systematic review and meta-analysis of randomized placebo-controlled trials?
### Response:
| Few eligible studies, and most had small population sizes. |
### Instruction:
Does low Expression of S100P be Associated With Poor Prognosis in Patients With Clear Cell Adenocarcinoma of the Ovary?
### Response:
| These data suggested that S100P may serve as an independent prognostic factor and marker for acquired resistance to chemotherapeutic drugs in clear cell adenocarcinoma. |
### Instruction:
Does gadd45γ regulate cardiomyocyte death and post-myocardial infarction left ventricular remodelling?
### Response:
| This work is the first to demonstrate that Gadd45γ accumulation during MI promotes the development and persistence of HF by inducing cardiomyocyte apoptosis in a p38 MAPK-dependent manner. We clearly identify Gadd45γ as a therapeutic target in the development of HF. |
### Instruction:
Is oxygen uptake more efficient in idiopathic pulmonary arterial hypertension than in chronic thromboembolic pulmonary hypertension?
### Response:
| OUEP and OUE@AT are higher in IPAH than that in CTEPH not in proportion to haemodynamics, probably due to differences in cardiac function and pulmonary vascular occlusion. OUEP correlates well with the exercise capacity and the severity of the disease. |
### Instruction:
Does high protein intake in neonatal period induce glomerular hypertrophy and sclerosis in adulthood in rats born with IUGR?
### Response:
| Neonatal HP feeding following IUGR affects renal functions and structure at adulthood. These alterations may result from a single nephron glomerular hyperfiltration. |
### Instruction:
Does sympathetic denervation of heart and kidney induce similar effects on ventricular electrophysiological properties?
### Response:
| This study showed that sympathetic denervation of the heart and kidney induced similar electrophysiological effects in ventricles. |
### Instruction:
Do an update on drugs for the treatment of menopausal symptoms?
### Response:
| The increasing numbers of therapies for menopausal symptoms open up new options, but we must individualize treatments. New possibilities arise in patients who did not have them and which can improve compliance and is also important to design strategies using combined or sequential treatments. |
### Instruction:
Does c-Jun NH2-Terminal Kinase and p38 Inhibition suppress Prostaglandin E2-Stimulated Aromatase and Estrogen Receptor Levels in Human Endometriosis?
### Response:
| PGE2 activates p38 and JNK signaling pathways, further stimulating c-Jun and activating transcription factor-2 binding to aromatase and ERB promoter regions with elevated estradiol production. Inhibition of JNK and P38 may be a potential method of treating human endometriosis. |
### Instruction:
Does varenicline decrease nicotine but not alcohol self-administration in genetically selected Marchigian Sardinian alcohol-preferring ( msP ) rats?
### Response:
| Varenicline is highly efficacious in decreasing nicotine self-administration either alone or in combination with alcohol. However, varenicline failed to influence both operant responding for alcohol and home-cage alcohol drinking in msP animals. Taken together, our findings suggest that the effects of varenicline could... |
### Instruction:
Does a Genetic Variant in TGFBR3-CDC7 be Associated with Visual Field Progression in Primary Open-Angle Glaucoma Patients from Singapore?
### Response:
| The presence of the index SNP rs1192415 (TGFBR3-CDC7) was associated with VF progression in POAG patients. These findings warrant further investigation in independent cohorts. |
### Instruction:
Do neurocognitive deficits increase risk of poor retention in care among older adults with newly diagnosed HIV infection?
### Response:
| Extending prior research on antiretroviral adherence and medication management, findings from this study indicate that neurocognitive impairment may be an especially salient risk factor for poor retention in care among older adults with newly diagnosed HIV infection. |
### Instruction:
Does caffeic acid ethanolamide prevent cardiac dysfunction through sirtuin dependent cardiac bioenergetics preservation?
### Response:
| CAEA prevents catecholamine-induced cardiac damage and is therefore a possible new therapeutic approach for preventing heart failure progression. |
### Instruction:
Is persistent high fever for more than 10 days during acute phase a risk factor for endothelial dysfunction in children with a history of Kawasaki disease?
### Response:
| Systemic endothelial dysfunction exists in children with a history of Kawasaki disease, and a febrile period of longer than 10 days during the acute phase is an independent predictor of endothelial dysfunction irrespective of coronary artery involvement. |
### Instruction:
Does optical coherence tomographic angiography show reduced deep capillary flow in paracentral acute middle maculopathy?
### Response:
| OCTA images the superficial and deep capillary plexi independently. PAMM is characterized by acute and chronic attenuation of the DCP flow signature. Focal lamellar ectopia in PAMM is discussed. |
### Instruction:
Is transforming growth factor-β signaling induced during prostate cancer cell death and neuroendocrine differentiation mediated by bone marrow stromal cells?
### Response:
| Collectively, our findings indicate that: (1) TGF-β family cytokines or regulated factors secreted from BMSCs are involved in prostate cancer apoptosis; (2) TGF-β signaling in prostate cancer cells is induced during neuroendocrine differentiation; and (3) TGF-β1 stimulation of BMSCs alters paracrine signaling to create... |
### Instruction:
Is eZH2 a sensitive marker of malignancy in salivary gland tumors?
### Response:
| EZH2 expression in salivary gland tumors, similarly to the tumors of other organs is not characteristic for any tumor type, but is a solid marker of the malignant nature of the tumors. |
### Instruction:
Is a toll-like receptor 9 ( rs352140 ) variant associated with placental inflammation in newborn infants?
### Response:
| The presence of a variant T allele in a common SNP (rs352140) in the TLR9 gene whose product recognizes bacterial DNA is associated with increased PI. |
### Instruction:
Is cancer cell invasion driven by extracellular matrix remodeling dependent on the properties of cancer-associated fibroblasts?
### Response:
| These findings showed two types of fibroblast-dependent cancer cell invasion that are dependent on and independent of the remodeling areas generated by CAFs. |
### Instruction:
Are iron deficiency in early pregnancy using serum ferritin and soluble transferrin receptor concentrations associated with pregnancy and birth outcomes?
### Response:
| Nearly one in five Australian women begin pregnancy with ID. Further investigation of excess maternal weight and inflammation in the relationships between ID and GDM and LGA infants is needed. |
### Instruction:
Does the RAB39B p.G192R mutation cause X-linked dominant Parkinson 's disease?
### Response:
| Our findings implicate RAB39B, an essential regulator of vesicular-trafficking, in clinically typical PD. Further characterization of normal and aberrant RAB39B function might elucidate important mechanisms underlying neurodegeneration in PD and related disorders. |
### Instruction:
Do cD57+ T-cells are a subpopulation of T-follicular helper cells in nodular lymphocyte predominant Hodgkin lymphoma?
### Response:
| We conclude that CD57+ T-cells are TFH cells and form a subpopulation of TFH cells in tonsils and NLPHL. |
### Instruction:
Does upregulation of microRNA-224 sensitize human cervical cells SiHa to paclitaxel?
### Response:
| The results suggests that miR-224 might serve as a predictor for paclitaxel response or a therapeutic target in cervical cancer therapy. |
### Instruction:
Is cardiopulmonary exercise testing predictive of return to work in cardiac patients after multicomponent rehabilitation?
### Response:
| CPX is a valid tool for assessing patients' ability to return to work. Therefore, it may be an essential part of functional assessment during CR for predicting participation in employment. |
### Instruction:
Does the CBM Complex underwrite NF-κB Activation to Promote HER2-Associated Tumor Malignancy?
### Response:
| The CBM complex bridges key signaling pathways to confer malignant phenotypes and metastatic potential in HER2-associated breast cancer. |
### Instruction:
Is intraoperative arterial blood pressure lability associated with improved 30 day survival?
### Response:
| Intraoperative arterial blood pressure lability occurs more often in hypertensive patients. Contrary to common belief, increased lability was associated with decreased 30 day mortality. |
### Instruction:
Does mipu1 inhibit lipid accumulation through down-regulation of CD36 in RAW264.7 cells?
### Response:
| It was demonstrated that Mipu1 inhibited the lipid accumulation of macrophages and it down-regulated CD36 expression in the presence of oxLDL. |
### Instruction:
Do somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms?
### Response:
| Specific somatic MED12 mutations in prostate cancer and uterine leiomyomas accumulate in two separate regions of the gene and promote tumorigenesis through clearly distinct mechanisms. |
### Instruction:
Is light pigmentation phenotype correlated with increased substantia nigra echogenicity?
### Response:
| Findings suggest an increasing prevalence of structural abnormality of substantia nigra with decreasing darkness of skin and thus may provide additional evidence in favor of a pathogenic link of pigmentation and Parkinson's disease. |
### Instruction:
Does a frailty index predict survival and incident multimorbidity independent of markers of HIV disease severity?
### Response:
| Among people aging with HIV in northern Italy, a frailty index based on deficit accumulation predicted survival and incident multimorbidity independently of HIV-related and behavioral risk factors. The frailty index holds potential value in quantifying vulnerability among people aging with HIV. |
### Instruction:
Is fecal pyruvate kinase suitable for discrimination between inflammatory bowel disease exacerbation and acute gastroenteritis?
### Response:
| The performance of M2-PK in distinguishing between children with moderate-to-severe IBD and patients with infectious gastroenteritis was inferior to FC. Neither test had sensitivity ands pecificity sufficient for everyday clinical application. |
### Instruction:
Does combined clopidogrel-aspirin treatment for high risk TIA or minor stroke increase cerebral microbleeds?
### Response:
| For the treatment of high-risk TIA or minor stroke patients, the clopidogrel-aspirin treatment did not increase the number of CMB than Aspirin alone. It appears that the extent of CMB was associated with the extent of existing CMB occurred in previous stroke, which was mostly located in cortical, subcortical zone. |
### Instruction:
Do dietary Intake Patterns Are Consistent Across Seasons in a Cohort of Healthy Adults in a Metropolitan Population?
### Response:
| People living in the metropolitan Washington, DC, area did not exhibit seasonal variation in dietary intake. Therefore, when designing studies of nutrient intake in a metropolitan population, these findings suggest that investigators do not need to consider the season during which diet is examined. |
### Instruction:
Do human factors approach to evaluate the user interface of physiologic monitoring?
### Response:
| High variability exists in monitoring station interaction performance among those participating in this project. Alarms were almost universally silenced without cognitive recognition of the alarm state. Education related to monitoring operations appeared largely absent in this sample. Most users perceived the interface... |
### Instruction:
Does overexpression of Trps1 contribute to tumor angiogenesis and poor prognosis of human osteosarcoma?
### Response:
| Trps1 plays a crucial role in osteosarcoma angiogenesis, metastasis and clinical surgical stage. Trps1 can be a novel promising prognostic marker and therapeutic target, and antiangiogenic therapy which targets Trps1 molecule in patients with osteosarcoma may lead to improved prognosis and longer-term survival. |
### Instruction:
Does teledermatology Implementation in a VHA Secondary Treatment Facility improve Access to Face-to-Face Care?
### Response:
| Implementation of a teledermatology program at the Mann-Grandstaff Spokane VA Medical Center improved access to face-to-face dermatology care. |
### Instruction:
Does icariside II ameliorate diabetic nephropathy in streptozotocin-induced diabetic rats?
### Response:
| ICA II treatment could ameliorate diabetic nephropathy in STZ-induced diabetic rats by increasing endothelial cell contents, downregulating TGF-β/Smad/CTGF signaling pathway and oxidative stress level, and promoting cell proliferation both in kidney cortex and medulla. These beneficial effects appear to be mediated by ... |
### Instruction:
Is admission vitamin D status associated with discharge destination in critically ill surgical patients?
### Response:
| Our results suggest that vitamin D status may be a modifiable risk factor for non-home discharge destination in surgical ICU patients. Future randomized, controlled trials are needed to determine whether vitamin D supplementation in surgical ICU patients can improve clinical outcomes such as the successful rate of disc... |
### Instruction:
Is stroke Risk Perception in Atrial Fibrillation Patients Associated with Clinical Stroke Risk?
### Response:
| Considering possible negative implications in terms of lack of motivation for lifestyle behavior change and adequate adherence to the treatment and monitoring of vitamin K antagonist, the apparent underestimation of risk by large subgroups warrants attention and needs further investigation with regard to possible behav... |
### Instruction:
Does microRNA-125b promote tumor metastasis through targeting tumor protein 53-induced nuclear protein 1 in patients with non-small-cell lung cancer?
### Response:
| These findings demonstrated that miR-125b promoted tumor metastasis via targeting TP53INP1 in human NSCLC cells, which uncovered a real clinical relevance of microRNAs in tumor biology, and provided novel potential candidates for NSCLC clinical practice. |
### Instruction:
Is thyroid transcription factor-1 expression significantly associated with mutations in exon 21 of the epidermal growth factor receptor gene in Chinese patients with lung adenocarcinoma?
### Response:
| Our study showed a significant association between TTF-1 positivity and the presence of EGFR mutations (exon 21) in the Chinese lung adenocarcinoma patients. We further identify that patients with disease stages III-IV who were positive for TTF-1 expression and EGFR mutations had a better postoperative survival than th... |
### Instruction:
Does combining Health Data used to Ignite Health System Learning?
### Response:
| We conceptualize a population health and care intelligence system capable of supporting health system learning and we put forward a set of maturity tests of progress toward such a system. A factor common to each test is data-action latency; a mature system spawns timely actions proportionate to the information that can... |
### Instruction:
Is skeletal muscle proteolysis associated with sympathetic activation and TNF-α-ubiquitin-proteasome pathway in liver cirrhotic rats?
### Response:
| Our findings suggest a potential role of the sympathetic system, in association with pro-inflammatory responses, in the pathogenesis of muscle wasting in liver cirrhosis. |
### Instruction:
Does ankle Plantarflexor Spasticity Restrict the Recovery of Ankle Plantarflexor Strength or Ankle Power Generation for Push-Off During Walking Following Traumatic Brain Injury?
### Response:
| Following TBI, people with ankle plantarflexor spasticity have significantly greater mobility limitations than those without spasticity, yet retain the capacity for recovery of self-selected walking speed, ankle plantarflexor strength, and APG. |
### Instruction:
Does gDF11 rescue aging-related pathological hypertrophy?
### Response:
| Our studies show that there is no age-related PCH in disease-free 24-month-old C57BL/6 mice and that restoring GDF11 in old mice has no effect on cardiac structure or function. |
### Instruction:
Does down-regulation of microRNA-26a and up-regulation of microRNA-27a contribute to aggressive progression of human osteosarcoma?
### Response:
| In conclusion, our findings suggested that expression level of miR-26a and miR-27a contributes to aggressive progression of this malignancy. Therefore, may have clinical potentials as a non-invasive diagnostic/prognostic biomarker for osteosarcoma patients. |
### Instruction:
Do [ Construction of acid-sensitive potassium channel-3 eukaryotic expression plasmid and its express in SH-SY5Y cells ]?
### Response:
| The eukaryotic expression vector pEGFP-TASK3 is successfully constructed and the cell line stably expressing TASK3-eGFP fusion is established which is important for their fundamental research and potential applications. |
### Instruction:
Does spinal Stabilization Using Orthopedic Extremity Instrumentation set During Operation Enduring Freedom-Afghanistan?
### Response:
| In the combat environment with sparse resources, unstable spine fractures may potentially be treated using instrumentation not specifically designed for spinal implantation. This is an off-label use, and the authors do not recommend the use of these techniques as standard treatment in most medical environments. |
### Instruction:
Does a stroke care management system prevent outcome differences related to time of stroke unit admission?
### Response:
| Time of admission to the stroke unit did not affect early outcomes or functional independence at 3 months. |
### Instruction:
Do oUTCOME OF CLIVAL CHORDOMAS AFTER SKULL BASE SURGERIES WITH MEAN FOLLOW-UP OF 10 YEARS?
### Response:
| Our results suggest that aggressive surgical removal improves the long-term outcome of patients with skull base chordoma. We would like to emphasize that skull base chordomas should be aggressively removed using various skull base approaches. |
### Instruction:
Does laparoscopic Distal Pancreatectomy Using the Modified Prolonged Prefiring Compression Technique reduce Pancreatic Fistula?
### Response:
| Our data confirm that the PFC technique is safe, feasible, and effective in reducing clinically significant PF post-Lap-DP in the United Kingdom patient population. |
### Instruction:
Does low-Friction Minilaparoscopy outperform Regular 5-mm and 3-mm Instruments for Precise Tasks?
### Response:
| In standard surgical simulator exercises,low-friction minilaparoscopic instruments outperformed both conventional 3- and 5-mm laparoscopic instruments for precise tasks. |
### Instruction:
Does adherent-invasive Escherichia coli exacerbate Antibiotic-associated Intestinal Dysbiosis and Neutrophil Extracellular Trap Activation?
### Response:
| Together, these data provide new insights into the detrimental effects of antibiotics on the gut microbiota, with clinically relevant implications for intestinal dysbiosis on neutrophil function and intestinal redox balance. |
### Instruction:
Do [ Psychosocial profile and family support perception in adults ]?
### Response:
| Both, moderate and high family dysfunctions are associated with altered psychosocial profile in adults. |
### Instruction:
Do ghrelin and Leptin Have a Complex Relationship with Risk of Barrett 's Esophagus?
### Response:
| Higher levels of ghrelin were associated with an increased risk of Barrett's esophagus among the general population. In contrast, leptin was positively associated with frequent GERD symptoms, but inversely associated with the risk of Barrett's esophagus among the GERD controls. |
### Instruction:
Does mELD-XI Score predict Early Mortality in Patients After Heart Transplantation?
### Response:
| This is the first known study to examine the relationship between a high MELD-XI score and outcomes in patients after OHT. Patients with hepatic or renal dysfunction before OHT should be closely monitored and aggressively optimized as early mortality appears to drive long-term outcomes. |
### Instruction:
Is obesity associated with increased postoperative complications after total elbow arthroplasty?
### Response:
| Obesity and associated medical comorbidities place patients at increased risk for complications after TEA. Obese patients and especially morbidly obese patients thinking of undergoing TEA should be appropriately counseled preoperatively about their increased risk for complications. |
### Instruction:
Does synteny analysis in Rosids with a walnut physical map reveal slow genome evolution in long-lived woody perennials?
### Response:
| Slow rates of nucleotide substitution are accompanied by slow rates of synteny erosion during genome divergence in woody perennials. |
### Instruction:
Are the FOUR LIPS and MYB88 transcription factor genes widely expressed in Arabidopsis thaliana during development?
### Response:
| In addition to stomatal and reproductive development, FLP and MYB88, which are R2R3 MYB transcription factor genes, are expressed in many locations in cells, tissues, and organs. |
### Instruction:
Are down-regulation of miR-133a and miR-539 associated with unfavorable prognosis in patients suffering from osteosarcoma?
### Response:
| These results suggest that decreased miR-133a and miR-539 expressions may participate in the progression of osteosarcoma. Together, these results showed that miR-133a and miR-539 may have their role in both progression and prognosis of osteosarcoma. |
### Instruction:
Is early Life Antibiotic Exposure Associated with Growth in Young Children of Vellore , India?
### Response:
| Antibiotic exposures early in life were not associated with increased or decreased growth. The combination of malnutrition and recurrent illness likely complicate the relationship between antibiotic exposures and growth among children in low and middle-income countries. |
### Instruction:
Does use of attribute association error probability estimate to evaluate quality of medical record geocodes?
### Response:
| The effort to detect and store estimates of AAEP is worthwhile because of the increase in confidence fostered by the attribute association level approach to the assessment of uncertainty in patient geocodes, relative to existing geocoding related uncertainty metrics. |
### Instruction:
Is neutrophil CD64 upregulated in RA patients with lymphoma but not in other solid cancers?
### Response:
| The quantitative measurement of neutrophil CD64 by flow cytometry may be useful as a subsidiary diagnostic marker in patients with suspected lymphoma. Although neutrophil CD64 is currently a well-known marker of infection, it is necessary to bear in mind that lymphoma is also a candidate in differential diagnosis when ... |
### Instruction:
Do [ Mini-open repair for the treatment of acute closed achilles tendon ruptures ]?
### Response:
| The surgical treatment of acute achilles tendon rupture with mini-open repair has advantages of little invasion, a low rate of incision problems, quick function recovery, and simple operation, and it is suitable for primary hospital. |
### Instruction:
Does deficiency of macrophage migration inhibitory factor attenuate tau hyperphosphorylation in mouse models of Alzheimer 's disease?
### Response:
| These results suggest that MIF deficiency is associated with reduced astrocyte activation and tau hyperphosphorylation in the mouse AD models tested. Inhibition of MIF and MIF-induced astrocyte activation may be useful in AD prevention and therapy. |
### Instruction:
Do larval and adult environmental temperatures influence the adult reproductive traits of Anopheles gambiae s.s?
### Response:
| Our study shows that environmental temperature during the larval stages as well as during the adult stages affects Anopheles life-history parameters. Data on how temperature and other climatic factors affect vector life-history parameters are necessary to parameterise more reliably models predicting how global warming ... |
### Instruction:
Does dexamethasone induce apoptosis in pulmonary arterial smooth muscle cells?
### Response:
| Dexamethasone exerted reverse-remodelling effects by augmenting apoptosis and reversing inflammation in PASMC possibly via inhibition of NF-κB. Future PAH therapies may involve targeting these important inflammatory pathways. |
### Instruction:
Do toll-like receptor profiling of seven trophoblast cell lines warrants caution for translation to primary trophoblasts?
### Response:
| The characterized trophoblast cell line TLR profiles serve as a reference and warrant caution when selecting trophoblast cell lines as in vitro models for immune responses in primary trophoblasts. |
### Instruction:
Does the basophil surface marker CD203c identify Aspergillus species sensitization in patients with cystic fibrosis?
### Response:
| Combining the BAT with routine serologic testing allows classification of patients with CF into 3 groups: nonsensitized, A fumigatus-sensitized, and ABPA. Accurate and prompt identification of A fumigatus-associated clinical status might allow early and targeted therapeutic intervention, potentially improving clinical ... |
### Instruction:
Does inactivation of the prelimbic or infralimbic cortex impair decision-making in the rat gambling task?
### Response:
| Online activity of the IL or PrL cortex is important for maintaining an optimal decision-making strategy, but optimal performance on the rGT does not require frontal cortex dopamine D2 receptor activation. Additionally, these results demonstrate that the roles of different cortical regions in cost-benefit decision-maki... |
### Instruction:
Does timing of shoot development transitions affect degree of perenniality in Arabidopsis lyrata ( Brassicaceae )?
### Response:
| Based on these results and those of previous QTL studies, we propose a model in which the degree of shoot vegetative development shapes the developmental context for reproduction and subsequent vegetative growth in different environments. Climate-specific effects of shoot development patterns on reproductive output and... |
### Instruction:
Is the comparative efficacy of bivalirudin markedly attenuated by use of radial access : insights from Blue Cross Blue Shield of Michigan Cardiovascular Consortium?
### Response:
| Bivalirudin is markedly efficacious in reducing bleeding in patients undergoing TFI. The reduction in bleeding associated with bivalirudin use is minimal to absent in patients undergoing TRI. Given its lower cost and comparable outcomes, heparin should be the preferred anticoagulation strategy in those undergoing radia... |
### Instruction:
Is urotensin II receptor on preoperative biopsy associated with upstaging and upgrading in prostate cancer?
### Response:
| UTII-R expression on biopsy was associated with Gleason upgrading and pathology upstaging in prostate cancer patients. |
### Instruction:
Does sT-segment depression resolution predict infarct size and reperfusion injury in ST-elevation myocardial infarction?
### Response:
| Patients with acute STEMI and worsened or incomplete STD-R after PCI show a more pronounced myocardial as well as microvascular damage as detected by CMR with subsequent independent prognostic information on MACE over a 12-month follow-up period. |
### Instruction:
Does effectiveness of Evidence-based Pneumonia CPOE Order set Measured by Health Outcomes?
### Response:
| Evidence-based ordering practices have the potential to improve pneumonia outcomes through reduction of mortality, hospital readmissions, and cost of care. However, the practice must be part of a larger strategic effort to reduce variability in patient care processes. Further experimental and/or observational studies a... |
### Instruction:
Does comparative genomics of Steinernema reveal deeply conserved gene regulatory networks?
### Response:
| We have identified a set of expanded gene families that are likely to be involved in parasitism. We have also identified a set of non-coding motifs associated with groups of orthologous genes in Steinernema and Caenorhabditis involved in neurogenesis and embryonic development that are likely part of conserved protein-D... |
### Instruction:
Does heme Attenuation ameliorate Irritant Gas Inhalation-Induced Acute Lung Injury?
### Response:
| The data suggest that attenuating heme may prove to be a useful adjuvant therapy to treat patients with ALI. |
### Instruction:
Do human embryonic lung fibroblasts treated with artesunate exhibit reduced rates of proliferation and human cytomegalovirus infection in vitro?
### Response:
| In addition to its robust antiviral activity, ART inhibits proliferation of HCMV-infected lung fibroblasts, making it a potential next-generation drug for CMV pneumonia treatment and for reducing fibroproliferation and fibrosis in these patients. |
### Instruction:
Do effects of BPA and BPS exposure limited to early embryogenesis persist to impair non-associative learning in adults?
### Response:
| Building upon previous observations using the C. elegans model, we have shown that exposure of embryos to BPA and BPS affects their behavior as adults. These long-term effects are in line with recommended alternate low-dose chemical safety testing approaches. Our observation that the effects of BPS are similar to BPA i... |
### Instruction:
Does computed Tomography be More Sensitive than Ultrasound for the Diagnosis of Acute Cholecystitis?
### Response:
| Computed tomography is more sensitive than US for the diagnosis of AC and is most often used in patients without typical clinical signs of AC. |
### Instruction:
Does contractile function assessment by intraventricular balloon alter the ability of regional ischaemia to evoke ventricular fibrillation?
### Response:
| IVB inflation does not inhibit VF suppression by a standard drug, but it has profound antiarrhythmic effects of its own, likely to be due to inflation-induced localized ischaemia. This means rhythm and contractility cannot be assessed concurrently by this approach, with implications for drug discovery and safety assess... |
### Instruction:
Does dynamic High-Cadence Cycling improve Motor Symptoms in Parkinson 's Disease?
### Response:
| These findings show that dynamic cycling can improve PD motor function and that activation of proprioceptors with a high cadence but variable pattern may be important for motor improvements in PD. |
### Instruction:
Does body mass index modulate the relationship of sugar-sweetened beverage intake with serum urate concentrations and gout?
### Response:
| These data suggest that BMI influences serum urate and gout risk in response to chronic SSB intake, and renal tubular uric acid handling in response to an acute fructose load. In addition to many other health benefits, avoidance of SSBs may be particularly important in those with overweight/obesity to prevent hyperuric... |
### Instruction:
Does whole-genome bisulfite sequencing of cell-free DNA identify signature associated with metastatic breast cancer?
### Response:
| This unbiased analysis of cell-free (cf) DNA identified 21 DNA hypermethylation hotspots associated with MBC and demonstrated the ability to distinguish tumor-specific changes from normal-derived signals at the whole-genome level. This signature is a potential blood-based biomarker that could be advantageous at the tim... |
### Instruction:
Are loci associated with N-glycosylation of human IgG associated with rheumatoid arthritis : a Mendelian randomisation study?
### Response:
| In a large, well-powered cohort of RA patients, we show SNPs driving levels of N-glycosylation have no association with RA susceptibility, indicating colocalisation of associated SNPs are not necessarily indicative of a shared genetic background or a role for glycosylation in disease susceptibility. |
### Instruction:
Does miR-363 induce transdifferentiation of human kidney tubular cells to mesenchymal phenotype?
### Response:
| miR-363 induces transdifferentiation of human kidney tubular cells via upregulation of TWIST/canonical WNT pathway. |
### Instruction:
Do bacterial social interactions drive the emergence of differential spatial colony structures?
### Response:
| This work advances our fundamental understanding of bacterial social interactions and population structures and, simultaneously, benefits synthetic biology for facilitated engineering of artificial microbial consortia. |
### Instruction:
Does resting-state connectivity of the amygdala predict response to cognitive behavioral therapy in obsessive compulsive disorder?
### Response:
| Our results suggest that two different sub-regions of the amygdala and their respective neural networks are affected in OCD: the superficial amygdala and networks related to evaluation of reinforcers and risk anticipation and the basolateral amygdala which is implicated in fear processing. The diminished CBT response i... |
### Instruction:
Do three circulating long non-coding RNAs act as biomarkers for predicting NSCLC?
### Response:
| RP11-397D12.4, AC007403.1, and ERICH1-AS1 may be potential biomarkers for predicting the tumorigenesis of NSCLC in the future. |
### Instruction:
Is pAPP-A2 expression by osteoblasts required for normal postnatal growth in mice?
### Response:
| Locally-produced PAPP-A2 is required for normal bone growth. |
### Instruction:
Is pulmonary hypertension an independent predictor of cardiovascular events and mortality in haemodialysis patients?
### Response:
| Pulmonary hypertension is a common finding in HD patients and a valuable predictor of mortality and cardiovascular events. Prospective studies are needed to assess the effect of intervention on risk factors in improving patient's outcomes. |
### Instruction:
Do functionalized gold nanoparticles improve afatinib delivery into cancer cells?
### Response:
| Conjugating PEGAuNPs with afatinib is a promising antitumor delivery system for cancer therapy as it improves drug efficacy, allowing a reduction in drug dose used and minimizing possible toxicity-related side effects. |
### Instruction:
Is cognitive Function of Patients with Crohn 's Disease Associated with Intestinal Disease Activity?
### Response:
| Cognitive performance is related to CD activity and nutritional status. The results provide insight into potential influence of nutrition and inflammation on cognitive function. Further studies on cognitive function of patients with CD are warranted. |
### Instruction:
Is urinary 11-dehydro-thromboxane B2 associated with cardiovascular events and mortality in patients with atrial fibrillation?
### Response:
| Urinary 11-dehydro-TxB2 levels are associated with a residual risk of CVEs and CV mortality in patients with AF despite anticoagulant treatment. |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.