question stringlengths 52 373 | long_answer stringlengths 1 3.34k |
|---|---|
### Instruction:
Does [ Interdisciplinary geriatric intervention among nursing home residents with hip fracture reduce mortality ]?
### Response:
| Geriatric interdisciplinary intervention among residents in nursing homes has a positive effect and improves survival and reduces non-elective readmission within three months. Still, there is uncertainty about the effect of fluid therapy and blood transfusions and further investigations are needed. |
### Instruction:
Does growth hormone status predict left ventricular mass in patients after cure of acromegaly?
### Response:
| Patients who develop GHD following cure of acromegaly do not demonstrate elevated LV mass, in contrast to patients with a history of acromegaly but normal GH levels or to patients with active acromegaly. This suggests that GH status after treatment of acromegaly correlates with LV mass, and that, in GH sufficient patients, reversal of remodeling may be slower than previously thought. These data suggest that it will be important to determine whether GH replacement alters left ventricular morphology over time. |
### Instruction:
Do openers of small conductance calcium-activated potassium channels selectively enhance NO-mediated bradykinin vasodilatation in porcine retinal arterioles?
### Response:
| In porcine retinal arterioles, bradykinin increases endothelial cell calcium leading to activation of SK(Ca) and IK(Ca) channels. Without altering endothelial cell calcium, NS309 and CyPPA open SK(Ca) channels that enhance NO-mediated bradykinin relaxations. These results imply that opening SK(Ca) channels improves endothelium-dependent relaxation and makes this channel a potential target for treatments aimed at restoring retinal blood flow. |
### Instruction:
Does haemin-enhanced expression of haem oxygenase-1 stabilize erythrocyte-induced vulnerable atherosclerotic plaques?
### Response:
| Haem oxygenase-1 may eliminate haem or other oxidants, exert unexpected anti-oxidative and anti-inflammatory effects and serve as a promising approach to the direct inhibition of erythrocyte-induced plaque instability. |
### Instruction:
Is the transient receptor potential channel antagonist SKF96365 a potent blocker of low-voltage-activated T-type calcium channels?
### Response:
| SKF was a potent blocker of LVA T-type Ca channels. We suggest caution in the interpretation of results using SKF alone as a diagnostic agent for TRPC activity in native tissues. |
### Instruction:
Is immune cell-derived c3 required for autoimmune diabetes induced by multiple low doses of streptozotocin?
### Response:
| The data reveal a key role for immune cell-derived C3 in the pathogenesis of murine multiple low-dose streptozotocin-induced diabetes and support the concept that immune cell mediated diabetes is in part complement-dependent. |
### Instruction:
Does a locomotor innovation enable water-land transition in a marine fish?
### Response:
| My results demonstrate that axial tail twisting serves as a key innovation enabling invasion of a novel marine niche. This paper highlights the potential of using this system to address general evolutionary questions about water-land transitions and niche invasions. |
### Instruction:
Does informed decision making affect health-related quality of life in lung cancer screening ( NELSON trial )?
### Response:
| Subjects who did not make an informed decision to participate in lung cancer CT screening trial did not experience worse HRQoL during screening than subjects who did make an informed decision, either in general or after receiving an indeterminate result. |
### Instruction:
Is wnt2 expression and signaling increased by different classes of antidepressant treatments?
### Response:
| These findings demonstrate that Wnt2 expression and signaling is a common target of antidepressants and that increased Wnt2 is sufficient to produce antidepressant effects. |
### Instruction:
Is abnormal integrity of long association fiber tracts associated with cognitive deficits in patients with remitted geriatric depression : a cross-sectional , case-control study?
### Response:
| This study suggested that association fiber tracts between remote cortexes may yield important new clues to predict whether a patient will eventually develop Alzheimer's disease. |
### Instruction:
Does activation of liver X receptors with T0901317 attenuate cardiac hypertrophy in vivo?
### Response:
| Together these results indicate that LXR exerts salutary effects in cardiac hypertrophy, possibly via metabolic remodelling. |
### Instruction:
Are doppler signals observed during high temperature thermal ablation the result of boiling?
### Response:
| The value of T1 was near the standard boiling point of water (99.61 degrees C) while T2 was below it. Together, T1 and T2 support the conclusion that DUS during high temperature thermal ablation are the result of boiling (phase change). This conclusion is also supported by the nearly constant temperature histories maintained at locations from which DUS emanated. |
### Instruction:
Does tranilast attenuate the up-regulation of thioredoxin-interacting protein and oxidative stress in an experimental model of diabetic nephropathy?
### Response:
| This is the first study to demonstrate that tranilast not only has anti-inflammatory and anti-fibrotic effects as previously reported but also attenuates the up-regulation of Txnip and oxidative stress in diabetic nephropathy. |
### Instruction:
Are fibrinogen estimates influenced by methods of measurement and hemodilution with colloid plasma expanders?
### Response:
| This study demonstrated that different automated coagulation analyzers revealed significantly different levels of fibrinogen. The presence of colloid plasma expander gave rise to erroneous high levels of fibrinogen returned from some coagulation analyzers employing the method of Clauss. |
### Instruction:
Is reduction in Down 's syndrome screening acceptance predominantly observed in women aged 25-35 years?
### Response:
| It is apparent that the noted overall decline in the trends of serum screening uptake are due to the reduced uptake by the 25-35 years age group. |
### Instruction:
Does hepatitis C virus core protein induce malignant transformation of biliary epithelial cells by activating nuclear factor-kappaB pathway?
### Response:
| Hepatitis C virus core protein activates NF-kappaB pathway in hBE cells by increasing the phosphorylation of IkappaBalpha. The pathway may be responsible for HCV-C-induced malignant transformation of hBE cells. |
### Instruction:
Does hGF protect rat mesangial cells from high-glucose-mediated oxidative stress?
### Response:
| HGF could function as an antioxidant factor and protect against HG-mediated oxidative stress by enhancing ROS scavenging and suppressing ROS production. |
### Instruction:
Does basophil FcepsilonRI histamine release parallel expression of Src-homology 2-containing inositol phosphatases in chronic idiopathic urticaria?
### Response:
| In CIU basophils, the observed changes in FcepsilonRI signaling pathway molecule expression may underlie changes in releasability. |
### Instruction:
Does differentiation of monocytes into macrophages induce the upregulation of histamine H1 receptor?
### Response:
| Differentiation of monocytes into macrophages or dendritic cells is associated with profound changes of histamine receptor expression. Upregulation of H(1) receptors confers on macrophages the capacity of being activated by histamine. |
### Instruction:
Does the level of persistent HIV viremia increase after successful simplification of maintenance therapy to lopinavir/ritonavir alone?
### Response:
| The level of persistent viremia did not increase after stopping NRTI therapy among subjects who maintained virus suppression < 50 copies/ml on LPV/r alone through 48 weeks. This supports further studies of induction-simplification therapy for treatment of HIV-1 infection including the identification of factors predicting success or failure of simplified therapy. |
### Instruction:
Is increased carotid intima-media thickness in HIV patients associated with increased cytomegalovirus-specific T-cell responses?
### Response:
| HIV-infected subjects had thicker carotid IMT compared to controls. While HIV patients also had higher T-cell activation, hs-CRP levels, and CMV-specific T-cell responses, only CMV-specific T-cell responses were independently associated with IMT. Accelerated atherosclerosis in HIV patients may be mediated by heightened CMV-induced immune responses. |
### Instruction:
Is angiopoietin-2 increased in severe sepsis : correlation with inflammatory mediators?
### Response:
| First, patients' serum Ang-2 levels are increased during severe sepsis and associated with disease severity. The strong relationship of serum Ang-2 with serum tumor necrosis factor-alpha suggests that the latter may participate in the regulation of Ang-2 production in sepsis. Second, inflammatory mediators reduce Ang-2 release from human lung microvascular endothelial cells, implying that this vascular bed may not be the source of increased Ang-2 in human sepsis. |
### Instruction:
Do mortality in Emergency Department Sepsis ( MEDS ) score predicts 1-year mortality?
### Response:
| Although the score was initially derived for 28-day in-hospital mortality, our results indicate that the MEDS score also predicts patient survival at 1 yr after index hospital visit with suspected infection. The score needs external validation before widespread use. |
### Instruction:
Are low levels of high-density lipoprotein cholesterol associated with vascular remodeling in cardiac transplant recipients?
### Response:
| Low levels of HDL-C are an independent predictor of brachial artery enlargement in stable cardiac transplant recipients. These findings suggest that suboptimal HDL-C levels may be associated with the development of vascular remodeling and atherosclerosis in this population. |
### Instruction:
Are worries the mother of many diseases : general practitioners and refugees in the Netherlands on stress , being ill and prejudice?
### Response:
| No fundamental difference in paradigms was found between refugees and GPs as to the negative influence worries and bad experiences can have on health. For a fruitful cooperation to develop, based on trust, GPs need to invest in the relationship with individual refugees, and avoid actions based on prejudice. |
### Instruction:
Does insulin glulisine impart effective glycaemic control in patients with Type 2 diabetes?
### Response:
| Glulisine was non-inferior to RHI in reducing HbA(1c) in T2DM. Glulisine demonstrated superior postprandial glucose control and was associated with fewer nocturnal hypoglycaemic episodes, indicating clinical benefits. |
### Instruction:
Does determinants of life expectancy in medullary thyroid cancer : age matter?
### Response:
| In MTC patients, extrathyroidal extension and stage at diagnosis are the only independent predictors of (recurrence-free) life expectancy. Patients diagnosed in an early stage of disease and patients without detectable recurrence have favourable life expectancy independently of biochemical cure. |
### Instruction:
Does a new ATP-sensitive potassium channel opener protect endothelial function in cultured aortic endothelial cells?
### Response:
| Iptakalim is a promising drug that could protect against endothelial dysfunction through activating K(ATP) channels in endothelial cells. |
### Instruction:
Does taurine chloramine inhibit proliferation of rheumatoid arthritis synoviocytes by triggering a p53-dependent pathway?
### Response:
| We propose that Tau-Cl inhibits proliferation of RA FLS by triggering a p53-dependent cell-cycle arrest and conclude that this compound suppresses pathways in FLS that are known to contribute to the pathology of RA. |
### Instruction:
Are the eumelanin and pheomelanin contents in dorsal hairs of female recessive yellow mice greater than in male?
### Response:
| The Mc1r(e) gene stimulates pheomelanin synthesis in the epidermis, dermis and hair follicles. In addition, eumelanin and pheomelanin contents in Mc1r(e)/Mc1r(e) hairs may be influenced by the sex difference. |
### Instruction:
Is cognitive impairment equal in patients with epileptic and psychogenic nonepileptic seizures?
### Response:
| Many patients with PNES do not put forth maximal effort during neuropsychological assessment. When patients with PNES put forth valid effort, they demonstrate less objective evidence of neuropathologic injury or disease than do patients with ES. The cognitive impairment reported by this group appears to be more a function of motivational (although not necessarily intentional) factors than of verifiable neuropathology. |
### Instruction:
Does chewing chitosan-containing gum effectively inhibit the growth of cariogenic bacteria?
### Response:
| These findings suggest that a supplementation of chitosan to gum is an effective method for controlling the number of cariogenic bacteria in situations where it is difficult to brush one's teeth, such as when an individual is away from home all day or participating in outdoor training. |
### Instruction:
Does stent-based local delivery of nuclear factor-kappaB decoy attenuate in-stent restenosis in hypercholesterolemic rabbits?
### Response:
| Stent-based local delivery of NF-kappaB decoy reduced in-stent neointimal formation with no evidence of incomplete healing. These data suggest that this strategy may be a practical and promising means for prevention of in-stent restenosis in humans. |
### Instruction:
Do comparative study of dosimetry between high-dose-rate and permanent prostate implant brachytherapies in patients with prostate adenocarcinoma?
### Response:
| HDR brachytherapy of the prostate can provide better dose coverage, conformity, and homogeneity compared to PPI. |
### Instruction:
Are immunohistochemical patterns of reactive microenvironment associated with clinicobiologic behavior in follicular lymphoma patients?
### Response:
| Our results demonstrate the existence of two specific patterns in the reactive microenvironment of FL, an immunosurveillance pattern (T lymphocytes and macrophages) and an immune-escape pattern (CD57+ T cells), that were directly associated with the clinicobiologic features of these patients. |
### Instruction:
Does resident psychiatrists as assessors for lecture in continued medical education in psychiatry?
### Response:
| Ongoing evaluation of classroom lectures by resident psychiatrists may provide valuable feedback to instructors and impact the quality of medical education. The "classic" role of the teacher organization and enthusiasm are the most important components of quality education. |
### Instruction:
Does behavioural disturbance trigger recognition of dementia by family informants?
### Response:
| Recognition of memory problems by family members is associated with increasing behavioural disturbance. Even with recognition of dementia, families often fail to seek medical attention. Education of the lay public on the early signs and symptoms of dementia must be a key first step in improving recognition of dementia in the community dwelling elderly. |
### Instruction:
Does coronary bypass grafting using crossclamp fibrillation result in reliable reperfusion of the myocardium when the crossclamp is intermittently released : a prospective cohort study?
### Response:
| Crossclamp fibrillation does not result in reliable reperfusion of the myocardium between periods of crossclamping. |
### Instruction:
Does calcium supplementation of saline-based colloids produce equivalent coagulation profiles to similarly balanced salt preparations?
### Response:
| The different coagulation profiles between the 2 pentastarch preparations, as well as similar profiles of pentastarch in saline and hetastarch in balanced electrolyte solution, suggest that calcium is not solely responsible for previously observed effects. |
### Instruction:
Do policosanolPlus and Neuroprevin ameliorate pesticide-mediated inhibition of neurite outgrowth and neurite degeneration?
### Response:
| The pesticide, bifenthrin, inhibits neurite formation and causes neurite retraction. PolicosanolPlus and Neuroprevin are nutraceutical supplements which ameliorate the effects of bifenthrin on neurite outgrowth and retraction. Dietary supplementation with PolicosanolPlus and Neuroprevin may protect against developmental and long-term neurodegenerative events that result from exposure to pesticides. |
### Instruction:
Does neonatal handling prevent the effects of phencyclidine in an animal model of negative symptoms of schizophrenia?
### Response:
| First, neonatal handling protects animals from acquiring the schizophrenic-like behavior provoked by sub-chronic PCP treatment, which was associated with a reduced HPA activity. Second, the beneficial properties of handling in stress responses seem to depend on the type of stress. |
### Instruction:
Does permanent direct his bundle pacing induce ventricular dyssynchrony unlike conventional right ventricular apical pacing . An intrapatient acute comparison study?
### Response:
| Direct His bundle pacing (also fused with adjacent septum capture) prevents pacing-induced ventricular dyssynchrony. |
### Instruction:
Does a `` two-step '' educational approach for patients taking oral anticoagulants improve therapy control?
### Response:
| A two-step educational approach for patients on long-term oral anticoagulation does not improve TSTR percentages in the short term. |
### Instruction:
Is serum dioxin-like activity associated with reproductive parameters in young men from the general Flemish population?
### Response:
| These data suggest an interaction of dioxin-like compounds with the secretory function of the seminal vesicles or prostate, possibly indirectly through an effect on testosterone secretion, at levels not affecting spermatogenesis as such. |
### Instruction:
Does early-life psychological stress exacerbate adult mouse asthma via the hypothalamus-pituitary-adrenal axis?
### Response:
| Early psychological and physical stresses aggravated adult asthma via hyporesponsiveness of the hypothalamic-pituitary-adrenal axis during antigen challenge and via a pathway(s) distinct from the hypothalamic-pituitary-adrenal axis or neurokinin-1 receptors. |
### Instruction:
Does basic fibroblast growth factor suppress retinal neuronal apoptosis in form-deprivation myopia in chicks?
### Response:
| Exogenous bFGF effectively ameliorates the excessive axial elongation and retinal neuron apoptosis in chronic form-deprivation myopia in chicks. It is possible that bFGF will be a promising therapeutic agent for high human myopia. |
### Instruction:
Does comparison of wavefront reconstructions with Zernike polynomials and Fourier transform?
### Response:
| Fourier full reconstruction is faster and more accurate than Zernike reconstruction, makes optimal use of slope information, and better represents ocular aberrations of highly aberrated eyes. |
### Instruction:
Does t-cell inhibition aggravate bacterial translocation from rat small bowel?
### Response:
| In the model of bacterial translocation from a defunctionalised loop of small bowel the inhibition of T cells does not increase bacterial translocation to mesenteric lymph nodes or promote the systemic spread of the translocating bacteria. This indicates that T cells do not have any important protective function against translocating microbes from defunctionalised small bowel. |
### Instruction:
Do prevalence and development of KIG-relevant symptoms in primary school students from Frankfurt am Main?
### Response:
| Our comparison of results gathered from 2000 and 2004 showed that as the children grew older, the prevalence of already-enlarged overjets increased, as did the frequency of deep bite. We observed fewer frontal open bites and crossbites in late mixed dentition. Treatment need according to current statutory health insurance directives was clearly higher in the late mixed dentition (41.4%) than in the early mixed dentition (8%). |
### Instruction:
Do isoflurane and propofol have similar effects on spinal neuronal windup at concentrations that block movement?
### Response:
| These data suggest that isoflurane and propofol have similar effects on neuronal windup in the spinal cord, although there was enhanced absolute windup at 1.2 MAC isoflurane for the 1 Hz stimulus. |
### Instruction:
Is extent of glomerular tubularization an indicator of the severity of experimental acute kidney injury in mice?
### Response:
| Increased levels of glomerular tubularization represent a poorly understood response to ischemic AKI in mice. As such, this glomerular 'tubularization score' may be useful to complement standard injury scores in experimental and, if detected, in clinical AKI. |
### Instruction:
Does dexamethasone alter bronchoalveolar lavage fluid proteome in a mouse asthma model?
### Response:
| Among all these newly identified protein targets of dexamethasone, AMCase and gob-5 have been shown to be pro-inflammatory in asthma. Downregulation of AMCase and gob-5 may be considered as two novel anti-inflammatory actions of glucocorticoid in asthma. |
### Instruction:
Is reduced telomere length in rheumatoid arthritis independent of disease activity and duration?
### Response:
| The reduced TRF length in a large group of patients with RA compared with controls has been shown. The reduction is apparently independent of disease duration and markers of disease severity, but is influenced by HLA-DRB1 genotype. |
### Instruction:
Are disposition and sterol-lowering effect of ezetimibe influenced by single-dose coadministration of rifampin , an inhibitor of multidrug transport proteins?
### Response:
| Coadministration of rifampin increases the maximum serum concentrations of ezetimibe but reduces its enterosystemic recycling, most likely by inhibition of the secretion of ezetimibe and its glucuronide via P-gp and MRP2. |
### Instruction:
Does continuous intraperitoneal insulin infusion increase the risk of organ-specific autoimmune disease in type 1 diabetic patients : results of a multicentric , comparative study?
### Response:
| As previously shown AIA (anti-insulin antibodies) levels were higher in CIpii than in CSII (32.9% vs 20.2%, P<0.0001) but no correlation was observed with either clinical or subclinical autoimmune disease. This large-scale study eliminates the possibility that CIpii increases the risk of autoimmune disease. |
### Instruction:
Is less anticipatory guidance associated with more subsequent injury visits among infants?
### Response:
| Disadvantaged children whose families received less injury guidance than other children in their cohort were more likely to have a subsequent injury visit. Further studies are needed to determine whether increased injury prevention counseling reduces injury visits. |
### Instruction:
Does human faecal microbiota develop the ability to degrade type 3 resistant starch during weaning?
### Response:
| Human faecal microbiota of all age groups is able to ferment lactulose in vitro quickly and completely. The ability to degrade RS-3, however, is only established during weaning. Whether fermentation-related production of short-chain fatty acids from RS-3 and concurrent modifications of the microbiota can result in potential health benefits to the host at this stage of life needs to be elucidated. |
### Instruction:
Is elevated circulating adiponectin in type 1 diabetes associated with long diabetes duration?
### Response:
| The increase in circulating adiponectin concentrations in patients with type 1 diabetes appears to be strongly associated with long diabetes duration, irrespective of the metabolic control. Among other factors, a putative role for residual beta-cell function in the regulation of circulating adiponectin levels can be considered but we did not find sufficient evidence for this in the present study. |
### Instruction:
Does phospholipase C-dependent control of cardiac calcium homeostasis involve a TRPC3-NCX1 signaling complex?
### Response:
| These results suggest a PLC-dependent recruitment of a TRPC3-NCX1 complex into the plasma membrane as a pivotal mechanism for the control of cardiac Ca2+ homeostasis. |
### Instruction:
Does coronary artery flow velocity profile measured by transthoracic Doppler echocardiography predict myocardial viability after acute myocardial infarction?
### Response:
| DDT of LAD flow velocity is strongly associated with myocardial viability after reperfused anterior AMI. Non-invasive TTDE of the LAD may be used in the acute phase to predict long-term viability of the jeopardised myocardium. |
### Instruction:
Does the Mayo Clinic quadratic equation improve the prediction of glomerular filtration rate in diabetic subjects?
### Response:
| In diabetic subjects, the MCQ has a similar diagnostic performance to the MDRD, but it does not underestimate normal GFR, which is an important advantage. |
### Instruction:
Does endothelial nitric oxide synthase activation lead to dilatory H2O2 production in mouse cerebral arteries?
### Response:
| H2O2-dependent dilation in mouse cerebral arteries appears to be a physiological eNOS-derived mechanism. |
### Instruction:
Do inappropriate drug use by Portuguese elderly outpatients -- effect of the Beers criteria update?
### Response:
| The application of the updated Beers criteria lead to higher rates of potentially inappropriate medication, and especially those responsible for more severe adverse outcomes. The results suggest that there is a need for interventions to improve instructions for safe drug use in the elderly patients and to decrease the number of medications whenever it is possible. This study suggests a high prevalence of potentially inappropriate drug use by the elderly patients of Lisbon region, Portugal. |
### Instruction:
Are anti-inflammatory effects of inhaled nitric oxide optimized at lower oxygen concentration in experimental Klebsiella pneumoniae pneumonia?
### Response:
| The overall beneficial effects of inhaled NO in anti-inflammation in the mature lungs with K. pneumoniae pneumonia are in favor of a combination with lower level of oxygen, which warrants clinical verification in the treatment of lung inflammatory injury. |
### Instruction:
Is food preparation by young adults associated with better diet quality?
### Response:
| To improve dietary intake, interventions among young adults should teach skills for preparing quick and healthful meals. |
### Instruction:
Is vitamin supplement intake related to dietary intake and physical activity : The Child and Adolescent Trial for Cardiovascular Health ( CATCH )?
### Response:
| Adolescents who use multiple vitamin supplements have more healthful dietary and lifestyle behaviors than nonusers. Further study on supplement use by adolescents, including other types of supplements used and reasons for use, is warranted. |
### Instruction:
Does repetitive optokinetic stimulation induce lasting recovery from visual neglect?
### Response:
| We conclude that the presentation of moving visual stimulus displays with active smooth pursuit eye movements can be more efficient than conventional visual scanning training using static visual displays. |
### Instruction:
Does heme oxygenase-1 mediate cytoprotection against nitric oxide-induced cytotoxicity via the cGMP pathway in human pulp cells?
### Response:
| These findings of a link between HO-1, regulated via the cGMP system and NO-induced cytotoxicity in human pulp cells, suggest a protective role for HO-1 in pulpal inflammation. |
### Instruction:
Is the expression of CD9 in the peri-implantation mouse uterus upregulated in an ovarian steroid hormone-dependent manner?
### Response:
| The results of the current investigation showed that CD9 was differentially expressed in the uterus depending on the stage of implantation and was upregulated in ovarian steroid hormone-dependent manner, implicating multiple roles of CD9 in the regulation of embryo implantation during the peri-implantation period. |
### Instruction:
Is serum C-reactive protein response to percutaneous coronary intervention in patients with unstable or stable angina pectoris associated with the risk of clinical restenosis?
### Response:
| The CRP response to PCI, as a model to stimulate inflammation, is associated with an increased risk of clinical restenosis. The results emphasize the role of CRP in the pathogenesis of coronary artery disease progression and in particular restenosis. |
### Instruction:
Do daily goal pursuits predict cortisol secretion and mood states in employed parents with preschool children?
### Response:
| These findings speak to a person-centered approach in research on stress by showing that knowledge of individual goals is important for an understanding of affective and neuroendocrine stress reactions in employed parents with preschool children. |
### Instruction:
Does treatment of periorbital wrinkles by repeated medium-depth chemical peel in dark-skinned individuals?
### Response:
| It can be concluded that fine and/or medium periorbital wrinkling responds favorably to repeated, medium-depth chemical peels even in dark-skinned individuals with few mild side effects. |
### Instruction:
Does plasma Epstein-Barr viral deoxyribonucleic acid quantitation complement tumor-node-metastasis staging prognostication in nasopharyngeal carcinoma?
### Response:
| Pretherapy circulating EBV DNA load is an independent prognostic factor to International Union Against Cancer (UICC) staging in NPC. Combined interpretation of EBV DNA data with UICC staging data leads to alteration of risk definition of patient subsets, with improved risk discrimination in early-stage disease. Validation studies are awaited. |
### Instruction:
Does persistent lactic acidosis in neonatal hypoxic-ischaemic encephalopathy correlate with EEG grade and electrographic seizure burden?
### Response:
| Serum lactate levels in the first 30 minutes of life do not predict the severity of the ensuing encephalopathy. In contrast, sustained lactic acidosis is associated with severe encephalopathy on EEG and correlates with seizure burden. |
### Instruction:
Does endothelial nitric oxide synthase keep erection regulatory function balance in the penis?
### Response:
| These data suggest that endothelial NO has a role in the penis as a regulator of the basal signaling functions of the NO and RhoA/Rho-kinase erection mediatory pathways. These data offer new insight into the homeostasis of erection regulatory biology. |
### Instruction:
Is serum adiponectin a predictor of coronary heart disease : a population-based 10-year follow-up study in elderly men?
### Response:
| In this population-based cohort of healthy men, elevated serum levels of adiponectin were associated with a lower risk for CHD. Importantly, the association between adiponectin and CHD was independent of other well-known risk factors. |
### Instruction:
Are e-cadherin promoter polymorphisms associated with the aggressiveness of prostate cancer in Caucasian patients?
### Response:
| We conclude that E-cadherin -160C-->A and/or -347G-->GA polymorphisms are not associated with the aggressiveness of prostate cancer in Caucasian patients. |
### Instruction:
Does [ A new triterpenoid saponin from stem of Akebia trifoliata ]?
### Response:
| Compound II, named mutongsaponin C, is a new triterpenoid saponin and others were isolated from the stems of Akebia trifoliata (Thunb.) Koidz. var. australis (Diels) Rehd for the first time. |
### Instruction:
Do children undergoing cardiac surgery for complex cardiac defects show imbalance between pro- and anti-thrombotic activity?
### Response:
| Our data suggest that children with complex cardiac defects undergoing cardiac surgery show profound but transient imbalance between pro- and anti-thrombotic activity, which could lead to thromboembolic complications. These alterations are more important after TCPC than after biventricular repair but seem to be determined mainly by low antithrombin III. |
### Instruction:
Do perceptions of safety culture vary across the intensive care units of a single institution?
### Response:
| Significant safety culture variation exists across ICUs of a single hospital. ICU nursing directors tend to overestimate their personnel's attitudes, particularly for teamwork. Culture assessments based on institutional level analysis or director opinion may be flawed. |
### Instruction:
Are negative mesenteric effects of lung recruitment maneuvers in oleic acid lung injury transient and short lasting?
### Response:
| In an oleic acid lung injury model, three repeated RMs did not improve systemic oxygenation or lung mechanics. Negative effects on mesenteric oxygenation and metabolism were transient and short lasting. The intestinal effects of PC during RMs were minor and opposing, showing preserved oxygenation but a trend toward worsened mucosal perfusion. |
### Instruction:
Do na+/Ca2+ exchanger inhibitors modify the accumulation of tumor-diagnostic PET tracers in cancer cells?
### Response:
| A possible masking effect of NCX medication must be taken into consideration during the diagnostic interpretation of PET scans. |
### Instruction:
Does intraoperative infusion of amino acids induce anabolism independent of the type of anesthesia?
### Response:
| Epidural anesthesia provided no additional benefit beyond the anabolism obtained with amino acids. |
### Instruction:
Does the dietary antioxidant resveratrol affect redox changes of PPARalpha activity?
### Response:
| A nutritional substance, such as RES, is able to influence the activity of gene-regulating factors, but the net effect is difficult to predict when the compound involved has multiple biological properties. Caution is therefore warranted before drawing conclusions about the potential benefits of RES for human health. |
### Instruction:
Does dexamethasone stimulate expression of C-type Natriuretic Peptide in chondrocytes?
### Response:
| Our data suggest that the growth-suppressive activities of DEX are not due to blockade of CNP signaling. This study reveals a novel, unanticipated relationship between glucocorticoid and CNP signaling and provides the first evidence that CNP expression in chondrocytes is regulated by endocrine factors. |
### Instruction:
Does postoperative pain significantly influence postoperative blood loss in patients undergoing total knee replacement?
### Response:
| In patients undergoing TKR, there is a significant correlation between measured blood loss and morphine consumption from 12 to 18 hours. It is concluded that postoperative pain significantly influences postoperative blood loss in patients undergoing TKR. |
### Instruction:
Is second-line chemotherapy with pegylated liposomal doxorubicin and carboplatin highly effective in patients with advanced ovarian cancer in late relapse : a GINECO phase II trial?
### Response:
| PLD plus carboplatin is highly effective, prolongs OS, and is well tolerated in women with AOC in late relapse previously treated with both platinum and taxanes. Evaluation of this regimen in phase III trials is warranted. |
### Instruction:
Does protease-activated receptor-2 protect against pancreatitis by stimulating exocrine secretion?
### Response:
| Trypsin released during the early stages of pancreatitis activates PAR-2 receptors on the acinar cells and stimulates secretion from these cells. Thus, PAR-2 activation may decrease pancreatic injury and limit the severity of pancreatitis by allowing extracellular trypsin to act as a secretagogue. |
### Instruction:
Does early use of a phosphodiesterase inhibitor after brachytherapy restore and preserves erectile function?
### Response:
| The early use of PDEIs after BT is associated with a significant improvement in and maintenance of erectile function compared with late use. Men undergoing BT should be encouraged to use PDEIs early after implantation, to preserve erectile function. |
### Instruction:
Are polycomb-group oncogenes EZH2 , BMI1 , and RING1 overexpressed in prostate cancer with adverse pathologic and clinical features?
### Response:
| PcG proteins EZH2, BMI1, and RING1 are associated with adverse pathologic features and clinical PSA recurrence of prostate cancer. Whereas BMI1 and RING1 are abundantly present in prostate cancer, EZH2 is expressed at relatively low levels, making it a less obvious target for therapy. |
### Instruction:
Do positive short-term subjective effect of sports drink supplementation during recovery?
### Response:
| Supplementation with a sports drink during recovery showed a significant short-term subjective positive effect compared with placebo. However, no effects were seen on physical performance or signs of overtraining. |
### Instruction:
Does creatine supplementation impair the thermoregulatory response during a bout of exercise in the heat?
### Response:
| Cr loading did not impair the thermoregulatory response during a bout of exercise in the heat. |
### Instruction:
Are subsyndromal depressive symptoms associated with functional impairment in patients with bipolar disorder : results of a large , multisite study?
### Response:
| These findings clearly demonstrate the public health significance of subsyndromal depression in the bipolar population. The most appropriate interventions for subsyndromal depressive symptoms in patients with bipolar disorder remain to be determined. |
### Instruction:
Is unusually mild tuberous sclerosis phenotype associated with TSC2 R905Q mutation?
### Response:
| Codon 905 missense mutations in TSC2 are relatively common. The TSC2 R905Q mutation is associated with unusually mild disease, consistent with functional studies. Combined with previous reports, it is apparent that certain TSC2 missense mutations are associated with a mild form of tuberous sclerosis, which in many patients does not meet standard diagnostic criteria. These findings have implications for the large number of patients with limited clinical features of TSC and for genetic counseling in these families. |
### Instruction:
Does multimodality noninvasive imaging demonstrate in vivo cardiac regeneration after mesenchymal stem cell therapy?
### Response:
| With serially obtained MRI and MDCT, we demonstrate in vivo reappearance of myocardial tissue in the MI zone accompanied by time-dependent restoration of contractile function. These data are consistent with a regenerative process, highlight the value of noninvasive multimodality imaging to assess the structural and functional basis for myocardial regenerative strategies, and have potential clinical applications. |
### Instruction:
Does arsenic trioxide affect signal transducer and activator of transcription proteins through alteration of protein tyrosine kinase phosphorylation?
### Response:
| These results suggest a selective activity of arsenic trioxide on PTKs and will assist in developing clinical trials in AML. |
### Instruction:
Does dominant-negative fibroblast growth factor receptor expression enhance antitumoral potency of oncolytic herpes simplex virus in neural tumors?
### Response:
| By using multiple therapeutic mechanisms, including destruction of both tumor cells and tumor endothelial cells, an oncolytic HSV encoding dnFGFR enhances antitumor efficacy. This strategy can be applied to other oncolytic viruses and for clinical translation. |
### Instruction:
Does sD-1029 inhibit signal transducer and activator of transcription 3 nuclear translocation?
### Response:
| These results show that SD-1029 directly abrogates the Jak-Stat3 signaling pathway in human cancer cells expressing constitutively active Stat, and add to the growing literature that validates this pathway as a viable target for further drug development. Finally, SD-1029 may represent a suitable prototype for structural optimization and exploration as a therapeutic lead. |
### Instruction:
Does combination mammalian target of rapamycin inhibitor rapamycin and HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin have synergistic activity in multiple myeloma?
### Response:
| These studies provide the basis for potential clinical evaluation of this combination for multiple myeloma patients. |
### Instruction:
Is the axis of polarity of the mouse blastocyst specified before blastulation and independently of the zona pellucida?
### Response:
| These findings further support the view that the Em-Ab axis of the mouse blastocyst is normally prepatterned and provide no evidence of a role for the ZP in its specification. |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.