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### Instruction:
Does meta-epidemiologic analysis indicate that MEDLINE searches are sufficient for diagnostic test accuracy systematic reviews?
### Response:
| Restricting to studies indexed on MEDLINE did not influence the summary estimates of the meta-analyses in our sample. In certain circumstances, for instance, when resources are limited, it may be appropriate to restrict searches to MEDLINE. However, the impact on individual reviews cannot be predicted. |
### Instruction:
Does patient perception of understanding health education and instructions have moderating effect on glycemic control?
### Response:
| Our results revealed that not only were patients with adequate health literacy associated with good glycemic control but patients with marginal health literacy were also able to achieve good glycemic control. Adequate health literacy and better understanding of health education is highly correlated. The role of adequate health literacy on glycemic control could be suppressed if variables are over-controlled during analysis. |
### Instruction:
Are measures of spontaneous and movement-evoked pain associated with disability in patients with whiplash injuries?
### Response:
| This study examined the degree to which measures of spontaneous and movement-evoked pain accounted for shared or unique variance in functional disability associated with whiplash injury. The findings suggest that approaches to the clinical evaluation of pain would benefit from the inclusion of measures of movement-evoked pain. |
### Instruction:
Is nephron-sparing surgery superior to radical nephrectomy in preserving renal function benefit even when expanding indications beyond the traditional 4-cm cutoff?
### Response:
| The renal function benefit carried out by elective PN over RN persists even when expanding nephron-sparing surgery indications beyond the traditional 4-cm cutoff. |
### Instruction:
Does anterior locking plate reduce trochanteric fracture migrations during hip extension?
### Response:
| Hip extension provides a plausible explanation for the high rate of post-operative failures of greater trochanter fixations. An antero-lateral locking plate represents an efficient surgical alternative counteracting the multi-directional greater trochanter movements occurring during hip extension. |
### Instruction:
Does overexpression of p300 correlate with poor prognosis in patients with cutaneous squamous cell carcinoma?
### Response:
| Our results indicate that high p300 expression is associated with aggressive features of cSCC and suggest that p300 expression, as examined by IHC, will be a promising biomarker for predicting clinical outcomes in patients with cSCC. |
### Instruction:
Does next-generation sequencing reveal frequent consistent genomic alterations in small cell undifferentiated lung cancer?
### Response:
| Greater than 50% of the SCLC cases harboured at least one actionable alteration. Given the limited treatment options and poor prognosis of patients with SCLC, comprehensive genomic profiling has the potential to identify new treatment paradigms and meet an unmet clinical need for this disease. |
### Instruction:
Does the CMYA5 gene confer risk for both schizophrenia and major depressive disorder in the Han Chinese population?
### Response:
| Our findings support the idea that specific alleles and haplotype in the CMYA5 confer genetic risk for both schizophrenia and major depressive disorder in the Han Chinese population. |
### Instruction:
Is circulating human epidermal growth factor receptor 2 ( HER2 ) associated with hyperglycaemia and insulin resistance?
### Response:
| There is an independent association between HER2 levels and hyperglycemia and insulin resistance that is not modified by country of birth. |
### Instruction:
Do neutrophil to lymphocyte ratio changes predict small hepatocellular carcinoma survival?
### Response:
| Increased NLR, but not high preoperative NLR or postoperative NLR, helps to predict worse OS and RFS in patients with small HCC who underwent curative resection. |
### Instruction:
Is dNA methylation altered in B and NK lymphocytes in obese and type 2 diabetic human?
### Response:
| Both obesity and T2D are associated with an altered epigenetic signature of the immune system in a cell type-specific manner. These changes could contribute to the altered immune functions associated with obesity and insulin resistance. |
### Instruction:
Is periostin required for maximal airways inflammation and hyperresponsiveness in mice?
### Response:
| In mice, periostin is required for maximal airways hyperresponsiveness and inflammation after HDM sensitization and challenge. Periostin is required for maximal HDM-induced T-cell responses. |
### Instruction:
Does microRNA-146a alleviate chronic skin inflammation in atopic dermatitis through suppression of innate immune responses in keratinocytes?
### Response:
| Our data demonstrate that miR-146a controls nuclear factor kappa B-dependent inflammatory responses in keratinocytes and chronic skin inflammation in AD. |
### Instruction:
Does cognitive impairment assessed at annual geriatric health examinations predict mortality among the elderly?
### Response:
| Cognitive impairment as measured by the SPMSQ is associated with an increased risk for mortality. Even mild cognitive impairment was associated with greater risk of mortality at a relatively short follow-up time. |
### Instruction:
Does socioeconomic status influence the likelihood but not the outcome of liver resection for colorectal liver metastasis?
### Response:
| Liver resection for CLM is performed more commonly among the least socioeconomically deprived population than among the most deprived. However, degree of deprivation was not associated with tumour recurrence after resection. |
### Instruction:
Does iL-33 promote ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice?
### Response:
| IL-33 is a novel profibrogenic cytokine that signals through ST2 to promote the initiation and progression of pulmonary fibrosis by recruiting and directing inflammatory cell function and enhancing profibrogenic cytokine production in an ST2- and macrophage-dependent manner. |
### Instruction:
Does versican regulate metastasis of epithelial ovarian carcinoma cells and spheroids?
### Response:
| Taken together these data suggest that versican regulates the development of peritoneal metastasis originating from cells and spheroids. |
### Instruction:
Does large blood pressure variability aggravate arteriolosclerosis and cortical sclerotic changes in the kidney in hypertensive rats?
### Response:
| Large BPV aggravates pre-glomerular arteriolosclerosis, which results in the cortical sclerotic changes in SHRs through a local angII-mediated mechanism. This study raised the possibility that ARB is useful for renal protection in patients who have a combination of hypertension and increased BPV. |
### Instruction:
Is [ Imbalance in the expression of Foxp3 , T-bet and GATA-3 correlated with inflammation of chronic obstructive pulmonary disease ]?
### Response:
| There is a relationship between inflammation and imbalance of in the expression of T-bet, GATA-3, Foxp3 in COPD. |
### Instruction:
Do [ Wortmannin and U0126 inhibit the promoting effect of insulin on differentiation of skeletal myoblasts in rats ]?
### Response:
| Wortmannin and U0126 can suppress the promoting effect of insulin on the differentiation of skeletal myoblasts into myocytes in rats and decrease the formation of myotubes and the expression of myogenin. |
### Instruction:
Does [ Tripterygium wilfordii polyglycoside suppress inflammatory cytokine expression in rats with diabetic nephropathy ]?
### Response:
| TWP treatment could reduce the expressions of inflammation cytokines in serum and kidney and relieve the nephropathy in diabetic rats. |
### Instruction:
Does resiliency Over Time of Elders ' Age stereotype After Encountering Stressful Events?
### Response:
| The robustness of negative age stereotypes was expressed in their capacity to resist change as well as generate it. |
### Instruction:
Is course of late-life depression in China chronic and unremitting?
### Response:
| The naturalistic course of depressive illness in older adult primary care patients in urban China is typically chronic and unremitting for those with severe symptoms and slowly improving for those with milder symptoms. Because access to specialty mental health care is limited, treatments for late-life depression need to be developed that can be effectively and feasibly implemented in Chinese primary care practices. |
### Instruction:
Does insulin inhibit Abeta production through modulation of APP processing in a cellular model of Alzheimer 's disease?
### Response:
| Our present data suggest that insulin could inhibit Abeta production through modulation of APP processing by increasing cleavage at the a-secretase site and decreased cleavage at the beta-secretase sites. |
### Instruction:
Are anti-TNFα therapies safe during pregnancy in women with inflammatory bowel disease : a systematic review and meta-analysis?
### Response:
| The use of anti-TNFα therapy does not seem to increase the risk of unfavorable pregnancy outcomes among women with IBD, although the optimal timing of therapy through pregnancy and the postpartum period was not assessed in this analysis. These data can help counsel patients around family planning and perinatal management. |
### Instruction:
Does perinatal Immunization With Vaccine-Grade Listeria monocytogenes provide Protection Against Murine Th2 Airway Inflammation?
### Response:
| Our findings highlight the promise of early life Lm-based immunomodulatory interventions as a prophylactic strategy for allergic asthma. |
### Instruction:
Is docosahexaenoic acid-induced apoptosis mediated by activation of mitogen-activated protein kinases in human cancer cells?
### Response:
| Together, these results indicate that DHA-induced MAPKs activation is dependent on its capacity to provoke mitochondrial ROS generation, and accounts for its cytotoxic effect in human cancer cells. |
### Instruction:
Does chronic cholesterol depletion by lovastatin suppress MUC5AC gene expression in human airway epithelial cells?
### Response:
| Chronic cholesterol depletion in the plasma membrane of NCI-H292 cells may be considered an antihypersecretory method, because it effectively inhibits mucin gene expression of human airway epithelial cells. |
### Instruction:
Does addition of sialidase or p38 MAPK inhibitors ameliorate decrements in platelet in vitro storage properties caused by 4 °C storage?
### Response:
| Addition of either sialidase or p38 MAPK inhibitors do not improve any in vitro parameters of PLTs stored at 4 °C in 100% plasma. |
### Instruction:
Is faster VO ( 2 ) kinetics after eccentric contractions explained by better matching of O ( 2 ) delivery to O ( 2 ) utilization?
### Response:
| We propose that the sped VO(2p) kinetics observed in the Slow group coupled with an improved [HHb]/VO(2p) ratio suggest a better matching of local muscle O2 delivery to O2 utilization following eccentric contractions. |
### Instruction:
Do validation of video motion-detection scoring of forced swim test in mice?
### Response:
| This computer-scoring method is an effective, fast, and low-cost method of quantifying the FST. It is validated by replicating statistical differences observed in traditional visual scoring. We also demonstrate a case of heterosis in the FST. |
### Instruction:
Does a modified open surgery technique for peritoneal dialysis catheter placement decrease catheter malfunction?
### Response:
| The modified open surgery technique is a reliable method for catheter placement. |
### Instruction:
Does whey protein modify gene expression related to protein metabolism affecting muscle weight in resistance-exercised rats?
### Response:
| A reduction in MAFbx gene transcription induced by whey protein and the interaction between exercise and whey protein ingestion on mTOR gene expression contributed significantly to differences in body and muscle weight gain. |
### Instruction:
Does excess body fat negatively affect bone mass in adolescents?
### Response:
| The results reveal a negative effect of BF% on bone mass in males and indicate that the higher the BF% among overweight adolescents, the lower the BMD and BMC values. |
### Instruction:
Is medicaid status associated with higher surgical site infection rates after spine surgery?
### Response:
| The study highlights the increased cost of spine surgical procedures for patients with a Medicaid payer status with the passage of the Patient Protection and Affordable Care Act of 2010. The Patient Protection and Affordable Care Act of 2010 provisions could cause a reduction in reimbursement to the hospital for taking care of patients with Medicaid insurance due to their higher complication rates and higher costs. This very issue could inadvertently lead to access limitations. |
### Instruction:
Does nitrofen increase total retinol levels in placenta during lung morphogenesis in the nitrofen model of congenital diaphragmatic hernia?
### Response:
| Increased placental retinol levels show that retinol is transferred from mother to placenta and stored in the placenta in nitrofen model of CDH during lung morphogenesis. Nitrofen may disturb the mobilization of retinol from placenta to fetal circulation causing PH in CDH. |
### Instruction:
Do comparison of ECOG/WHO performance status and ASA score as a measure of functional status?
### Response:
| The ASA score can be used as a proxy for ECOG/WHO PS in risk adjustment models predicting cancer surgery. Further studies should assess its broader application for other outcomes and in other settings. |
### Instruction:
Does [ Neutrophil-to-lymphocyte ratio predict the survival in patients with post-operative recurrence of non-small cell lung cancer ]?
### Response:
| An elevated NLR at recurrence indicates poor prognosis of NSCLC patients. NLR at recurrence may be an important independent prognostic factor of patients with recurrent NSCLC after curative resection. |
### Instruction:
Does comparative evaluation of the combined application of titanium implants and calcium phosphate bone substitute in a rabbit model?
### Response:
| The addition of BCP bone substitute to fill peri-implant gaps significantly enhanced both bone formation (~2.5-fold) and bone to implant contact (>2-fold) for the custom-made titanium implants with two-sided gaps. |
### Instruction:
Do pre-sentence mental health service use predicts post-sentence mortality in a population cohort of first-time adult offenders?
### Response:
| Mortality risk in the 2 years following sentence completion is associated with pre-sentence health service use and a range of socio-demographic factors for both incarcerated and non-custodial offenders. The opportunity afforded by imprisonment could be exploited by provision of funding to identify and treat mental illness, impart preventive health education addressing modifiable risk factors and provide transitional care to community-based services, all of which may help reduce preventable post-sentence deaths. Diversion to non-custodial sentences is also a plausible option. |
### Instruction:
Does pulmonary rehabilitation improve only some domains of health-related quality of life measured by the Short Form-36 questionnaire?
### Response:
| These patients had low SF-36 scores compared to the general population; changes in scores after PR were low. These patients may need frequent HRQL assessment during rehabilitation, and PR programs should consider program modification in patients with small changes in mental health. |
### Instruction:
Are adiposity , gut microbiota and faecal short chain fatty acids linked in adult humans?
### Response:
| The results support the hypothesis that colonic fermentation patterns may be altered, leading to different faecal SCFA concentrations in OWOB compared with LN humans. More in-depth studies looking at the metabolic fate of SCFA produced in LN and OWOB participants are needed in order to determine the role of SCFA in obesity. |
### Instruction:
Do quantitative assessment of inferior oblique muscle overaction using photographs of the cardinal positions of gaze?
### Response:
| We describe a new method for measuring the degree of inferior oblique muscle overaction using photographs of the cardinal positions. It has the potential to be a diagnostic tool that measures inferior oblique muscle overaction with minimal observer dependency. |
### Instruction:
Does analysis of the arabidopsis REM gene family predict functions during flower development?
### Response:
| The data suggest that the REM34, REM35 and REM36 group is the most interesting one, as REM34 is co-expressed with the floral meristem identity (FMI) genes, they are bound by AP1, SVP, AP3 and PI, and they are expressed in the floral meristem and during the earliest stages of flower development. However, it appears that high levels of functional redundancy may conceal the exact function of these transcription factor genes. |
### Instruction:
Does [ Heparin-binding hemagglutinin enhance Mycobacterium smegmatis infection by inhibiting autophagy in A549 cells ]?
### Response:
| The exogenous HBHA could enhance the infection ability of MS in A549 cells through inhibiting autophagy. |
### Instruction:
Is `` Shark the man ! `` : ethnoknowledge of Brazil 's South Bahia fishermen regarding shark behaviors?
### Response:
| This work demonstrates the complexity and robustness of artisanal fishermen's ichthyological knowledge of sharks. Therefore, we suggest that such knowledge should be considered to develop public policies for the control of the fishing activity, as well as to develop and consolidate the National Action Plan for the Conservation of Shark and Ray Species (PAN - Tubarões e Raias). |
### Instruction:
Are common variants in PERK , JNK , BIP and XBP1 genes associated with the risk of prediabetes or diabetes-related phenotypes in a Chinese population?
### Response:
| Common variants at PERK and BIP loci contributed to the risk of prediabetes, and the genetic variations in JNK and XBP1 genes are associated with diabetes-related clinical parameters in this Chinese population. |
### Instruction:
Does heparin inhibit burn-induced spleen cell apoptosis by suppressing interleukin-1 expression?
### Response:
| Heparin inhibits burn-induced apoptosis of the spleen cells by suppressing IL-1 expression in mice. |
### Instruction:
Are nADPH oxidase-generated reactive oxygen species required for stromal cell-derived factor-1α-stimulated angiogenesis?
### Response:
| We conclude that NOX is required for SDF-1α signaling and that intracellular redox balance is critical for SDF-1α-induced endothelial migration and angiogenesis. |
### Instruction:
Does imbalance between vascular endothelial growth factor and endostatin correlate with the prognosis of operable non-small cell lung cancer?
### Response:
| There was an imbalance between VEGF and endostatin in serum of operable NSCLC patients. The imbalance correlated with the prognosis of operable NSCLC. |
### Instruction:
Do polysaccharides from Tricholoma matsutake and Lentinus edodes enhance 5-fluorouracil-mediated H22 cell growth inhibition?
### Response:
| Polysaccharides from Lentinus edodes and Tricholoma matsutake could enhance the efficacy of 5-FU-mediated H22 cell growth inhibition. |
### Instruction:
Does the association between apolipoprotein M and insulin resistance vary with country of birth?
### Response:
| Our results show that ApoM levels differ according to country of birth and are associated with IR and T2DM only in Swedes. |
### Instruction:
Does disposition index identify defective beta-cell function in cystic fibrosis subjects with normal glucose tolerance?
### Response:
| β-Cell function as measured by DI is reduced in CF patients compared to non-CF controls-even in CF-NGT-and is decreased further in CF patients with diabetes. If DI proves to be a predictor of the development of CFRD in larger studies, then it could be used to identify CF patients who are at particularly high risk, allowing early interventions aimed to delay or prevent CFRD. |
### Instruction:
Does the compound Chinese medicine `` Kang Fu Ling '' protect against high power microwave-induced myocardial injury?
### Response:
| Microwave radiation can cause electrophysiological, histological and ultrastructural changes in the heart. KFL at 1.5 g/kg/day had the greatest protective effect on these cardiovascular events. mPTP plays an important role in the protective effects of KFL against microwave-radiation-induced myocardial injury. |
### Instruction:
Does mK2206 inhibit hepatocellular carcinoma cellular proliferation via induction of apoptosis and cell cycle arrest?
### Response:
| This study demonstrates the anti-tumor activity of MK2206 in HCC cells. The observed reduction in survivin and pro-caspase 9 suggests that MK2206 induces apoptosis. However, HCC proliferation is also halted via induction of cell cycle arrest as indicated by the increase in p21 and p27 expression and decrease in cyclinD1. Importantly, the concentration needed to achieve growth inhibition in HCC is lower than that needed for other cancer types. |
### Instruction:
Does constitutive overexpression of soybean plasma membrane intrinsic protein GmPIP1 ; 6 confer salt tolerance?
### Response:
| The general impact of overexpression of GmPIP1;6 suggests that it may be a multifunctional aquaporin involved in root water transport, photosynthesis and seed loading. GmPIP1;6 is a valuable gene for genetic engineering to improve soybean yield and salt tolerance. |
### Instruction:
Is the Moraxella catarrhalis-induced pro-inflammatory immune response enhanced by the activation of the epidermal growth factor receptor in human pulmonary epithelial cells?
### Response:
| The interaction between M. catarrhalis and EGFR increases airway inflammation caused by this pathogen. Our data suggest that the inhibition of EGFR signaling in COPD could be an interesting target for reducing M. catarrhalis-induced airway inflammation. |
### Instruction:
Do adipose derived mesenchymal stem cells efficiently rescue carbon tetrachloride-induced acute liver failure in mouse?
### Response:
| Direct transplantation of ADMSCs is an effective treatment for ALF. The transplanted ADMSCs exhibit the potential to differentiate into hepatocyte-like cells in the injured livers. |
### Instruction:
Does identification of abnormal screening mammogram interpretation using Medicare claim data?
### Response:
| Medicare claims may be a feasible data source for research or quality improvement efforts addressing high rates of abnormal screening mammography. |
### Instruction:
Is mTOR pathway involved in ADP-evoked astrocyte activation and ATP release in the spinal dorsal horn in a rat neuropathic pain model?
### Response:
| Our data demonstrated that ADP enhanced neuropathic pain in CCI rats, which was inhibited by rapamycin. This study indicates that targeting mTOR pathway could serve as a novel therapeutic strategy in neuropathic pain management. |
### Instruction:
Does hyaluronic acid enhance the effect of the PAMPS/PDMAAm double-network hydrogel on chondrogenic differentiation of ATDC5 cells?
### Response:
| The DN gel induced chondrogenic differentiation of ATDC5 cells without insulin. This effect was significantly affected by hyaluronic acid, depending on the level of concentration. There is a high possibility that hyaluronic acid plays an important role in the in vivo hyaline cartilage regeneration phenomenon induced by the DN gel. |
### Instruction:
Does tendinopathy alter cumulative transverse strain in the patellar tendon after exercise?
### Response:
| This study is the first to show that patellar tendinopathy is associated with altered morphological and mechanical response of the tendon to exercise, which is manifest by reduction in cumulative transverse strain and microvascularity, when present. Research directed toward identifying factors that influence the acute microvascular and transverse strain response of the patellar tendon to exercise in the various stages of tendinopathy is warranted. |
### Instruction:
Does aSIC3 contribute to the blunted muscle metaboreflex in heart failure?
### Response:
| Compared with those in controls, cardiovascular responses to lactic acid administered into the hind limb muscles are blunted in HF rats owing to attenuated ASIC3. This suggests that ASIC3 plays a role in engagement in the attenuated metaboreceptor component of the exercise pressor reflex in HF. |
### Instruction:
Does aliskiren ameliorate pressure overload-induced heart hypertrophy and fibrosis in mice?
### Response:
| ALK ameliorates heart hypertrophy, fibrosis and dysfunction in the mouse model in setting of chronic pressure overload, via suppressing Ang II-PKCβI-ERK1/2-regulated autophagy. |
### Instruction:
Do additive effects of HLA alleles and innate immune genes determine viral outcome in HCV infection?
### Response:
| This data supports a critical role for the adaptive immune response in the control of HCV in concert with the innate immune response. |
### Instruction:
Is low protein content of drainage fluid a good predictor for earlier chest tube removal after lobectomy?
### Response:
| Regardless of the daily drainage, chest tubes can safely be removed earlier than anticipated in most patients after lobectomy if the protein content of the draining fluid is low. |
### Instruction:
Do intraoperative experiments show relevance of inter-antagonistic mechanical interaction for spastic muscle 's contribution to joint movement disorder?
### Response:
| Our hypothesis is confirmed for most, but not all limbs tested. Therefore, tested inter-antagonistic mechanical interaction can certainly, but not exclusively be a factor for abnormal mechanics of the spastic muscle. |
### Instruction:
Does forefoot angle at initial contact determine the amplitude of forefoot and rearfoot eversion during running?
### Response:
| Possible mechanisms for the increased risk of running injuries associated with large forefoot angles are discussed. |
### Instruction:
Do bioactives of Artemisia dracunculus L. enhance insulin sensitivity by modulation of ceramide metabolism in rat skeletal muscle cells?
### Response:
| The observations suggest that insulin sensitization by PMI 5011 is partly mediated through moderation of glycosphingolipid accumulation. |
### Instruction:
Does polyphenol-rich Rutgers Scarlet Lettuce improve glucose metabolism and liver lipid accumulation in diet-induced obese C57BL/6 mice?
### Response:
| RSLE demonstrated antidiabetic effects in vitro and in vivo and may improve metabolic syndrome conditions of fatty liver and glucose metabolism. |
### Instruction:
Do artemisia dracunculus L. polyphenols complexed to soy protein show enhanced bioavailability and hypoglycemic activity in C57BL/6 mice?
### Response:
| Complexation with soy protein makes antidiabetic A. dracunculus polyphenols more bioavailable and bioaccessible. |
### Instruction:
Does artemisia supplementation differentially affect the mucosal and luminal ileal microbiota of diet-induced obese mice?
### Response:
| Marked differences in bacterial communities exist depending on the biogeographic compartment in the terminal ileum. Future studies testing the effects of Artemisia or other botanical supplements require larger sample sizes for adequate statistical power. |
### Instruction:
Is ventral striatum , but not cortical volume loss , related to cognitive dysfunction in type 1 diabetic patients with and without microangiopathy?
### Response:
| This study shows subcortical, but not cortical, volume loss in relation to cognitive dysfunction in patients with longstanding type 1 diabetes, irrespective of microangiopathy. The time course, pathophysiology, and clinical relevance of these findings need to be established in longitudinal and mechanistic studies. |
### Instruction:
Is hypermobility related with musculoskeletal pain in Indian school-children?
### Response:
| We found that a large proportion of Indian school children had hypermobility. There was an association between the presence of joint, back or ankle/foot pain with hypermobility in Indian school children. This association was strongest when a Beighton score cut-off of 4 was used to define hypermobility. |
### Instruction:
Does neonatal vaccination with plasmid DNA encoding Cyn d 1 effectively prevent allergic responses in mice?
### Response:
| This study shows the prophylactic effects of DNA vaccine encoding Bermuda grass pollen allergen Cyn d 1 on specific IgE responses in neonatal mice. |
### Instruction:
Do olfactory ensheathing cells promote differentiation of neural stem cells and robust neurite extension?
### Response:
| Overall, our findings suggest that cocultures of NSCs and OECs may be a novel combination therapy for neural injuries including spinal cord injury (SCI). Furthermore, we have identified a class of molecules which plays a substantial role in the behavior that provides new targets for investigating pharmacological therapies. |
### Instruction:
Is yAP1 a potential biomarker for cetuximab resistance in head and neck cancer?
### Response:
| Taken together, we provide evidence that YAP1 could represent a novel biomarker gene of cetuximab resistance in HNSCC cell lines. |
### Instruction:
Does inhibitory effect of St. John׳s Wort oil macerates on TNFα-induced NF-κB activation and their fatty acid composition?
### Response:
| This study sheds light on the fact that application of the proper traditional method to prepare olive oil macerates from Hypericum perforatum is able to get bioactive constituents in the oil. Besides, inhibition of TNFα-induced NF-κB activation appears to be a potential mechanism for topical wound healing activity of SJW oil macerates. |
### Instruction:
Is the graded cycling test combined with the talk test reliable for patients with ischemic heart disease?
### Response:
| The TT, combined with the GCT, was well tolerated by patients with cardiac disease in clinical settings with small measurement error and an excellent relative reliability. These results apply to both patient-rated and PT-rated TT. |
### Instruction:
Does loss of primary cilia occur early in breast cancer development?
### Response:
| These data suggest that primary cilia are lost early in breast cancer development on both the cancer cells and their surrounding stromal cells. |
### Instruction:
Is myeloperoxidase enzymatic activity increased in patients with different levels of dental crowding after initial orthodontic activation?
### Response:
| The amount of dental crowding does not seem to influence MPO activity, which showed similar patterns in GCF and saliva, but the values in GCF reflected the inflammatory changes more accurately than did the values in saliva. The quantification of MPO activity is a useful biologic marker as an indirect measurement of inflammation generated with tooth movement independent of the amount of crowding. |
### Instruction:
Does somatostatin receptor type 2 contribute to the self-renewal of murine embryonic stem cells?
### Response:
| The activation of SSTR2 contributes to the self-renewal of mESCs via activation of the STAT3 pathway. |
### Instruction:
Does rivastigmine but not vardenafil reverse cannabis-induced impairment of verbal memory in healthy humans?
### Response:
| The present data therefore suggest that acetylcholine plays an important role in cannabis-induced memory impairment, whereas similar results for glutamate have not been demonstrated in this study. |
### Instruction:
Does analysis of NHANES 1999-2002 data reveal noteworthy association of alcohol consumption with obesity?
### Response:
| Frequent or heavy alcohol consumption is associated with greater odds of being obese. |
### Instruction:
Is specific bioelectrical impedance vector analysis ( BIVA ) more accurate than classic BIVA to detect changes in body composition and in nutritional status in institutionalised elderly with dementia?
### Response:
| Overall, the findings of the present study suggest that specific BIVA is more effective than classic BIVA in identifying bioelectrical changes associated with psycho-functional and nutritional indicators in institutionalised elderly with dementia. |
### Instruction:
Do central and peripheral cardiovascular impairments limit VO ( 2peak ) in type 1 diabetes?
### Response:
| Both central and peripheral cardiovascular impairments limit VO(2peak) in physically active adults with type 1 diabetes. Importantly, central limitations, and probably peripheral limitations as well, are associated with glycemic control. |
### Instruction:
Do focus groups for developing a peer mentoring program to improve self-management in pediatric inflammatory bowel disease?
### Response:
| Many of the suggestions from the focus groups correspond with research findings associated with successful mentoring programs. Using participants' suggestions and empirically based best practices for mentoring may result in an effective peer mentoring program for improving self-management in youth with IBD. |
### Instruction:
Do [ Importance of EKG in patients wuth resynchronization therapy ]?
### Response:
| The presence of complete left bundle branch block before CRT implantation is associated with a better response to CRT compared to other myocardial intraventricular conduction disturbances. Post-implantation narrowing of QRS complex appears to be an early predictor of favorable response to CRT. |
### Instruction:
Does hand hygiene with alcohol hand rub and gloves reduce the incidence of late onset sepsis in preterm neonates?
### Response:
| Using a hand hygiene protocol with hand washing, hand rub and gloves significantly reduced the incidence of LOS in preterm newborns, and the results suggest that it may produce a sustained improvement in the infection rate. |
### Instruction:
Does a coimmunization vaccine of Aβ42 ameliorate cognitive deficits without brain inflammation in an Alzheimer 's disease model?
### Response:
| A coimmunization strategy leading to the development of a safe immunotherapeutic/preventive protocol against AD in humans is warranted. |
### Instruction:
Is creatinine excretion rate , a marker of muscle mass , related to clinical outcome in patients with chronic systolic heart failure?
### Response:
| Low urinary CER is associated with smaller body dimensions and more severe heart failure and is associated with an increased risk of adverse outcome. |
### Instruction:
Does computerized physician order entry and decision support improve ED analgesic ordering for renal colic?
### Response:
| The introduction of CPOE is associated with an increase in ketorolac use for ED renal colic visits. This may reflect the inclusion of ketorolac in the renal colic order set. Computerized physician order entry implementation with condition-specific electronic order sets and decision support may improve evidence-based practice. |
### Instruction:
Does synthesis of 53 tissue and cell line expression QTL datasets reveal master eQTLs?
### Response:
| Expression QTLs inform the interpretation of human trait variability, and may account for a greater fraction of phenotypic variability than protein-coding variants. The synthesis of available tissue eQTL data highlights many strong cis-eQTLs that may have important biologic roles and could serve as positive controls in future studies. Our results indicate some strong tissue-ubiquitous eQTLs may have adaptive origins in humans. Efforts to expand the genetic, splicing and tissue coverage of known eQTLs will provide further insights into human gene regulation. |
### Instruction:
Does hypercapnic hyperventilation shorten emergence time from Propofol and Isoflurane anesthesia?
### Response:
| The emergence time after intravenous anesthesia with propofol can be shortened significantly by using hyperventilation and hypercapnia, without any side effects. |
### Instruction:
Is rs964184 ( APOA5-A4-C3-A1 ) related to elevated plasma triglyceride levels , but not to an increased risk for vascular events in patients with clinically manifest vascular disease?
### Response:
| The single nucleotide polymorphism rs964184 (APOA5-A4-C3-A1) is associated with elevated plasma triglycerides concentrations in patients with clinically manifest vascular disease. In carriers of one minor allele, the effect on plasma triglycerides was modified by body mass index. There is no relation between rs964184 and recurrent vascular events in these patients. |
### Instruction:
Does neuromuscular fatigue alter postural control and sagittal plane hip biomechanics in active females with anterior cruciate ligament reconstruction?
### Response:
| Fatigue may induce lower extremity biomechanics and postural control deficits that may be associated with ACL injury in physically active females with ACL reconstruction. |
### Instruction:
Does the severity of liver injury following blunt trauma correlate with the number of fractured ribs : an analysis of a national trauma registry database?
### Response:
| Although the presence of rib fractures was associated with an increased probability of liver injury in patients with blunt torso trauma, there is no relationship between the number of fractured ribs and the severity of liver injury. |
### Instruction:
Does cross-sectional area of the abdomen predict complication incidence in patients undergoing sternal reconstruction?
### Response:
| Increases in abdominal morphomic measurements correlate strongly with the incidence of complications in patients undergoing sternal reconstruction. This finding may influence preoperative risk stratification and surgical decision making in this patient population. |
### Instruction:
Do religiously affiliated intensive care unit patients receive more aggressive end-of-life care?
### Response:
| Compared with nonaffiliated patients, religiously affiliated patients receive more aggressive EOL care in the ICU. However, this high-intensity care does not translate into any significant difference in survival. |
### Instruction:
Does huogu I formula prevent steroid-induced osteonecrosis in rats by down-regulating PPARgamma expression and activating wnt/LRP5/ beta-catenin signaling?
### Response:
| The results of our present study highlight the lipid-lowering potential of Huogu I formula, and provide further evidence of the involvement of the PPARgamma inhibition and Wnt/LRP5/ beta-catenin signaling activation in the effects of Huogu I formula. |
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