Split (1)

train · 816k rows

paragraph_index int64	sec string	p_has_citation int64	cites string	citeids list	pmid int64	cited_id string	sentences string	all_sent_cites list	sent_len int64	sentence_batch_index int64	sent_has_citation float64	qc_fail bool	cited_sentence string	cites_in_sentence list	cln_sentence string	is_cap bool	is_alpha bool	ends_wp bool	cit_qc bool	lgtm bool	__index_level_0__ int64
3	INTRODUCTION	1	23	[ "b23" ]	16,936,310	pmid-15597548	The development of ‘standalone workstations’ running higher-level graphic and command interfaces to the commonly used BLAST suite of software was recently described by Buisine and Chalmers (23).	[ "23" ]	194	10,000	1	false	The development of ‘standalone workstations’ running higher-level graphic and command interfaces to the commonly used BLAST suite of software was recently described by Buisine and Chalmers.	[ "23" ]	The development of ‘standalone workstations’ running higher-level graphic and command interfaces to the commonly used BLAST suite of software was recently described by Buisine and Chalmers.	true	true	true	true	true	1,594
3	INTRODUCTION	1	23	[ "b23" ]	16,936,310	pmid-15597548	However, the implementation reported is restricted to workstations running under the Unix operating system, and limited to the capabilities of the BLAST software.	[ "23" ]	162	10,001	0	false	However, the implementation reported is restricted to workstations running under the Unix operating system, and limited to the capabilities of the BLAST software.	[]	However, the implementation reported is restricted to workstations running under the Unix operating system, and limited to the capabilities of the BLAST software.	true	true	true	true	true	1,594
4	INTRODUCTION	0	null	null	16,936,310	null	Another platform available for the development of customized applications is based on the BioMoby system ().	null	108	10,002	0	false	null	null	Another platform available for the development of customized applications is based on the BioMoby system ().	true	true	true	true	true	1,595
4	INTRODUCTION	0	null	null	16,936,310	null	A tool built using BioMoby, called Taverna () offers an ‘open source’ platform employing Web-based ‘Grid Compuing’.	null	115	10,003	0	false	null	null	A tool built using BioMoby, called Taverna () offers an ‘open source’ platform employing Web-based ‘Grid Compuing’.	true	true	true	true	true	1,595
4	INTRODUCTION	0	null	null	16,936,310	null	It provides a graphic-user interface that enables one to assemble whole process lines using services provided by servers scattered over the internet without having to develop any software.	null	188	10,004	0	false	null	null	It provides a graphic-user interface that enables one to assemble whole process lines using services provided by servers scattered over the internet without having to develop any software.	true	true	true	true	true	1,595
5	INTRODUCTION	0	null	null	16,936,310	null	The computational platform utilized for the current study differs from the two customizable systems described above.	null	116	10,005	0	false	null	null	The computational platform utilized for the current study differs from the two customizable systems described above.	true	true	true	true	true	1,596
5	INTRODUCTION	0	null	null	16,936,310	null	It focuses on a PC-based implementation that evolved in response to the specific study described in this paper.	null	111	10,006	0	false	null	null	It focuses on a PC-based implementation that evolved in response to the specific study described in this paper.	true	true	true	true	true	1,596
5	INTRODUCTION	0	null	null	16,936,310	null	A battery of algorithms were embedded in an interactive network of graphic display and control screens, and interfaced with a server-based database.	null	148	10,007	0	false	null	null	A battery of algorithms were embedded in an interactive network of graphic display and control screens, and interfaced with a server-based database.	true	true	true	true	true	1,596
5	INTRODUCTION	0	null	null	16,936,310	null	These algorithms were designed to extract common subsequences from a group of DNA samples, extended to mono-gap sequences with a varying gap size.	null	146	10,008	0	false	null	null	These algorithms were designed to extract common subsequences from a group of DNA samples, extended to mono-gap sequences with a varying gap size.	true	true	true	true	true	1,596
5	INTRODUCTION	0	null	null	16,936,310	null	The results for gap sizes varying between 0 and 10 elements are utilized to identify common, double-gap segments, which are further extended to identify long common multi-gap sequences.	null	185	10,009	0	false	null	null	The results for gap sizes varying between 0 and 10 elements are utilized to identify common, double-gap segments, which are further extended to identify long common multi-gap sequences.	true	true	true	true	true	1,596
6	INTRODUCTION	1	24	[ "b24", "b25" ]	16,936,310	NA\|NA	The hardware platform consists of a Personal-Computer (PC)-based Workstation, which can be used in stand-alone mode or as part of a server-controlled, distributed network of PCs.	[ "24", "25" ]	178	10,010	0	false	The hardware platform consists of a Personal-Computer (PC)-based Workstation, which can be used in stand-alone mode or as part of a server-controlled, distributed network of PCs.	[]	The hardware platform consists of a Personal-Computer (PC)-based Workstation, which can be used in stand-alone mode or as part of a server-controlled, distributed network of PCs.	true	true	true	true	true	1,597
6	INTRODUCTION	1	24	[ "b24", "b25" ]	16,936,310	NA\|NA	Such platforms are commonplace in many research and process laboratories.	[ "24", "25" ]	73	10,011	0	false	Such platforms are commonplace in many research and process laboratories.	[]	Such platforms are commonplace in many research and process laboratories.	true	true	true	true	true	1,597
6	INTRODUCTION	1	24	[ "b24", "b25" ]	16,936,310	NA\|NA	The software platform was originally developed for the design, implementation, operation and teaching of manufacturing-process control networks, as described by Hazony (24,25).	[ "24", "25" ]	176	10,012	0	false	The software platform was originally developed for the design, implementation, operation and teaching of manufacturing-process control networks, as described by Hazony.	[ "24,25" ]	The software platform was originally developed for the design, implementation, operation and teaching of manufacturing-process control networks, as described by Hazony.	true	true	true	true	true	1,597
6	INTRODUCTION	1	24	[ "b24", "b25" ]	16,936,310	NA\|NA	It is particularly adept for iterative development of customized applications, providing a problem solving paradigm in which both problem specification and problem solution are concurrently refined through an iterative process.	[ "24", "25" ]	227	10,013	0	false	It is particularly adept for iterative development of customized applications, providing a problem solving paradigm in which both problem specification and problem solution are concurrently refined through an iterative process.	[]	It is particularly adept for iterative development of customized applications, providing a problem solving paradigm in which both problem specification and problem solution are concurrently refined through an iterative process.	true	true	true	true	true	1,597
6	INTRODUCTION	1	24	[ "b24", "b25" ]	16,936,310	NA\|NA	The present report describes such a customized application.	[ "24", "25" ]	59	10,014	0	false	The present report describes such a customized application.	[]	The present report describes such a customized application.	true	true	true	true	true	1,597
6	INTRODUCTION	1	24	[ "b24", "b25" ]	16,936,310	NA\|NA	However, the platform can be easily adapted for other purposes.	[ "24", "25" ]	63	10,015	0	false	However, the platform can be easily adapted for other purposes.	[]	However, the platform can be easily adapted for other purposes.	true	true	true	true	true	1,597
7	INTRODUCTION	0	null	null	16,936,310	null	Finally, the false-positive-identification (FPI) investigation, reported below, is based on two different methods: one, using searches of randomized samples, and the second, utilizing available bench-mark batches of 18 406 samples, each of 5000 elements upstream of genes (in relation the ATG switch), extracted from the...	null	474	10,016	0	false	null	null	Finally, the false-positive-identification (FPI) investigation, reported below, is based on two different methods: one, using searches of randomized samples, and the second, utilizing available bench-mark batches of 18 406 samples, each of 5000 elements upstream of genes (in relation the ATG switch), extracted from the...	true	true	true	true	true	1,598
8	INTRODUCTION	0	null	null	16,936,310	null	The focus of this study has been to describe an application of a computational platform that allows examination of the hypothesis that genes selectively expressed in one hematopoietic lineage share a unique combination of regulatory elements.	null	242	10,017	0	false	null	null	The focus of this study has been to describe an application of a computational platform that allows examination of the hypothesis that genes selectively expressed in one hematopoietic lineage share a unique combination of regulatory elements.	true	true	true	true	true	1,599
8	INTRODUCTION	0	null	null	16,936,310	null	Using the megakaryocyte as a model system, our study identified a cluster of sequences that are unique to gene promoters selectively active in this lineage.	null	156	10,018	0	false	null	null	Using the megakaryocyte as a model system, our study identified a cluster of sequences that are unique to gene promoters selectively active in this lineage.	true	true	true	true	true	1,599
8	INTRODUCTION	0	null	null	16,936,310	null	Within these sequences, Ets and GATA binding sites were recognized, imbedded in clusters of sequences highly selective to megakaryocyte promoters, and for which mammalian binding factors have not been identified yet.	null	216	10,019	0	false	null	null	Within these sequences, Ets and GATA binding sites were recognized, imbedded in clusters of sequences highly selective to megakaryocyte promoters, and for which mammalian binding factors have not been identified yet.	true	true	true	true	true	1,599
8	INTRODUCTION	0	null	null	16,936,310	null	The findings validate our unbiased search method for conserved regulatory elements within a related group of genes, as Ets and GATA binding sites have been previously described to regulate genes specifically expressed in megakaryocytes.	null	236	10,020	0	false	null	null	The findings validate our unbiased search method for conserved regulatory elements within a related group of genes, as Ets and GATA binding sites have been previously described to regulate genes specifically expressed in megakaryocytes.	true	true	true	true	true	1,599
8	INTRODUCTION	0	null	null	16,936,310	null	This method may be also used for searching other groups of genes within and out of the hematopoietic lineage.	null	109	10,021	0	false	null	null	This method may be also used for searching other groups of genes within and out of the hematopoietic lineage.	true	true	true	true	true	1,599
0	DISCUSSION	1	23	[ "b23" ]	16,936,310	pmid-14744438\|pmid-15735639\|pmid-15597548	The merit of a customized system is in its ability to fulfill the specific objectives of a particular research project.	[ "23" ]	119	10,022	0	false	The merit of a customized system is in its ability to fulfill the specific objectives of a particular research project.	[]	The merit of a customized system is in its ability to fulfill the specific objectives of a particular research project.	true	true	true	true	true	1,600
0	DISCUSSION	1	23	[ "b23" ]	16,936,310	pmid-14744438\|pmid-15735639\|pmid-15597548	Two web-based systems for customized application of Bioinformatics have been described in the literature (23); and the Taverna system ; .	[ "23" ]	137	10,023	1	false	Two web-based systems for customized application of Bioinformatics have been described in the literature ; and the Taverna system ;.	[ "23" ]	Two web-based systems for customized application of Bioinformatics have been described in the literature ; and the Taverna system ;.	true	true	true	true	true	1,600
0	DISCUSSION	1	23	[ "b23" ]	16,936,310	pmid-14744438\|pmid-15735639\|pmid-15597548	The methodology outlined in the present report was developed to respond to specific research requirements, providing for the development and application of customized-tool kits.	[ "23" ]	177	10,024	0	false	The methodology outlined in the present report was developed to respond to specific research requirements, providing for the development and application of customized-tool kits.	[]	The methodology outlined in the present report was developed to respond to specific research requirements, providing for the development and application of customized-tool kits.	true	true	true	true	true	1,600
0	DISCUSSION	1	23	[ "b23" ]	16,936,310	pmid-14744438\|pmid-15735639\|pmid-15597548	Our choice of the customization approach may reflect on the lack of sufficient expertise and/or resources to exploit the potential of available web-based methodologies, while having access to expertise in the development of customized-computer applications.	[ "23" ]	257	10,025	0	false	Our choice of the customization approach may reflect on the lack of sufficient expertise and/or resources to exploit the potential of available web-based methodologies, while having access to expertise in the development of customized-computer applications.	[]	Our choice of the customization approach may reflect on the lack of sufficient expertise and/or resources to exploit the potential of available web-based methodologies, while having access to expertise in the development of customized-computer applications.	true	true	true	true	true	1,600
1	DISCUSSION	0	null	null	16,936,310	pmid-11807806\|pmid-11553848\|NA\|pmid-14673175\|pmid-12356738\|pmid-10348704\|pmid-10739394\|pmid-12359731\|pmid-8639837\|pmid-11012226\|pmid-11807806\|pmid-12032776\|pmid-14673175\|pmid-11012226	The objective of the present study was to identify unique sequences, and clusters of sequences, common to a 9-member MegaKP group, and to explore the associated sequence-location information, which may shed light on the role played by such sequences in regulating lineage-specific expressions.	null	293	10,026	0	false	null	null	The objective of the present study was to identify unique sequences, and clusters of sequences, common to a 9-member MegaKP group, and to explore the associated sequence-location information, which may shed light on the role played by such sequences in regulating lineage-specific expressions.	true	true	true	true	true	1,601
2	DISCUSSION	1	32	[ "b32" ]	16,936,310	NA\|NA\|NA\|pmid-7584402\|NA\|pmid-10552946	Our methodology is outlined in the context of some of the results obtained for the megakaryocytic gene promoter group.	[ "32" ]	118	10,027	0	false	Our methodology is outlined in the context of some of the results obtained for the megakaryocytic gene promoter group.	[]	Our methodology is outlined in the context of some of the results obtained for the megakaryocytic gene promoter group.	true	true	true	true	true	1,602
2	DISCUSSION	1	32	[ "b32" ]	16,936,310	NA\|NA\|NA\|pmid-7584402\|NA\|pmid-10552946	The model employed has evolved through consecutive simple conceptual steps: (i) a simple model was initially implemented, consisting of a search for contiguous segments common to the entire group of sample; (ii) an extension of the searches to include single-gap sequences; (iii) an extension to searches for the common ...	[ "32" ]	694	10,028	1	false	The model employed has evolved through consecutive simple conceptual steps: (i) a simple model was initially implemented, consisting of a search for contiguous segments common to the entire group of sample; (ii) an extension of the searches to include single-gap sequences; (iii) an extension to searches for the common ...	[ "32" ]	The model employed has evolved through consecutive simple conceptual steps: (i) a simple model was initially implemented, consisting of a search for contiguous segments common to the entire group of sample; (ii) an extension of the searches to include single-gap sequences; (iii) an extension to searches for the common ...	true	true	true	true	true	1,602
3	DISCUSSION	0	null	null	16,936,310	pmid-15597548	The results presented in this report indicate that, when applied to the full MegaKP group, including both human and murine samples, the observed common sequences correspond to FPI indicators of the order of 10%.	null	211	10,029	0	false	null	null	The results presented in this report indicate that, when applied to the full MegaKP group, including both human and murine samples, the observed common sequences correspond to FPI indicators of the order of 10%.	true	true	true	true	true	1,603
3	DISCUSSION	0	null	null	16,936,310	pmid-15597548	However, splitting the study into the murine and human subgroups, results in an observed FPI-indicator Cap of 1% for the murine sub-group, while the human sub-group yielded a list characterized by FPI-indicator Cap as low as 0.01%.	null	231	10,030	0	false	null	null	However, splitting the study into the murine and human subgroups, results in an observed FPI-indicator Cap of 1% for the murine sub-group, while the human sub-group yielded a list characterized by FPI-indicator Cap as low as 0.01%.	true	true	true	true	true	1,603
3	DISCUSSION	0	null	null	16,936,310	pmid-15597548	These groups of sequences, which are primarily present in genes that are expressed selectively in the megakaryocytic lineage, are high candidates for regulatory domains.	null	169	10,031	0	false	null	null	These groups of sequences, which are primarily present in genes that are expressed selectively in the megakaryocytic lineage, are high candidates for regulatory domains.	true	true	true	true	true	1,603
3	DISCUSSION	0	null	null	16,936,310	pmid-15597548	Hence, our study suggests the existence of a DNA signature that consists of a unique combination of binding sites in the megakaryocytic, and provides a list of candidate sequences for future mutation studies to examine their functional significance individually and in combination.	null	281	10,032	0	false	null	null	Hence, our study suggests the existence of a DNA signature that consists of a unique combination of binding sites in the megakaryocytic, and provides a list of candidate sequences for future mutation studies to examine their functional significance individually and in combination.	true	true	true	true	true	1,603
3	DISCUSSION	0	null	null	16,936,310	pmid-15597548	The list of combination of sequences to potentially mutate for promoter activity studies is large and its availability to the research community allows full examination of these regions.	null	186	10,033	0	false	null	null	The list of combination of sequences to potentially mutate for promoter activity studies is large and its availability to the research community allows full examination of these regions.	true	true	true	true	true	1,603
4	DISCUSSION	0	null	null	16,936,310	null	It should be emphasized that the development of a PC-based customized platform does not preclude complementary, web-based studies.	null	130	10,034	0	false	null	null	It should be emphasized that the development of a PC-based customized platform does not preclude complementary, web-based studies.	true	true	true	true	true	1,604
4	DISCUSSION	0	null	null	16,936,310	null	Of most interest, when the newly identified human sequences were subjected to a web-based search against a database of known binding sites for transcription factors, several putative Ets binding sites were identified.	null	217	10,035	0	false	null	null	Of most interest, when the newly identified human sequences were subjected to a web-based search against a database of known binding sites for transcription factors, several putative Ets binding sites were identified.	true	true	true	true	true	1,604
4	DISCUSSION	0	null	null	16,936,310	null	Additional clusters of sequences were identified, for which binding factors have not been identified yet, e.g.	null	110	10,036	0	false	null	null	Additional clusters of sequences were identified, for which binding factors have not been identified yet, e.g.	true	true	true	true	true	1,604
4	DISCUSSION	0	null	null	16,936,310	null	the mammalian homolog of the yeast HSF (Figure 8C).	null	51	10,037	0	false	null	null	the mammalian homolog of the yeast HSF (Figure 8C).	false	true	true	true	false	1,604
4	DISCUSSION	0	null	null	16,936,310	null	When the murine conserved sequences in the megakaryocyte group (Figure 7) were similarly searched against the same databases, the Ets binding core was identified in sequence # 17 and HSF putative sites were recognized in sequences # 1 and 14 (Figure 7).	null	253	10,038	0	false	null	null	When the murine conserved sequences in the megakaryocyte group (Figure 7) were similarly searched against the same databases, the Ets binding core was identified in sequence # 17 and HSF putative sites were recognized in sequences # 1 and 14 (Figure 7).	true	true	true	true	true	1,604
4	DISCUSSION	0	null	null	16,936,310	null	These findings further validate our unbiased search method for conserved regulatory elements that might be significant within a related group of genes, as Ets biding sites have been previously described to regulate genes specifically expressed in megakaryocytes (see Introduction).	null	281	10,039	0	false	null	null	These findings further validate our unbiased search method for conserved regulatory elements that might be significant within a related group of genes, as Ets biding sites have been previously described to regulate genes specifically expressed in megakaryocytes (see Introduction).	true	true	true	true	true	1,604
4	DISCUSSION	0	null	null	16,936,310	null	This search could be applied in the future to identify potential regulatory elements in other groups of genes related by virtue of their unique expression in a specific lineage.	null	177	10,040	0	false	null	null	This search could be applied in the future to identify potential regulatory elements in other groups of genes related by virtue of their unique expression in a specific lineage.	true	true	true	true	true	1,604
5	DISCUSSION	0	null	null	16,936,310	null	The power of a methodology is manifested in having the flexibility to recognize and pursue new research venues based on the unique sequences identified.	null	152	10,041	0	false	null	null	The power of a methodology is manifested in having the flexibility to recognize and pursue new research venues based on the unique sequences identified.	true	true	true	true	true	1,605
5	DISCUSSION	0	null	null	16,936,310	null	The mechanism and implication of such a characteristic difference between the human and mouse groups are not clear at the moment.	null	129	10,042	0	false	null	null	The mechanism and implication of such a characteristic difference between the human and mouse groups are not clear at the moment.	true	true	true	true	true	1,605
5	DISCUSSION	0	null	null	16,936,310	null	Nevertheless, it raises an interesting possibility that there exists an intrinsic difference in the organization of upstream regulatory regions between the two mammalian genomes and that the human megakaryocyte-specific genes are commonly requested by a direct, or indirect, activation of the uniquely shared sequences i...	null	344	10,043	0	false	null	null	Nevertheless, it raises an interesting possibility that there exists an intrinsic difference in the organization of upstream regulatory regions between the two mammalian genomes and that the human megakaryocyte-specific genes are commonly requested by a direct, or indirect, activation of the uniquely shared sequences i...	true	true	true	true	true	1,605
6	DISCUSSION	0	null	null	16,936,310	NA\|NA	The usefulness of a methodology is demonstrated through the achievement and publication of meaningful scientific results, which is the main purpose of the present paper.	null	169	10,044	0	false	null	null	The usefulness of a methodology is demonstrated through the achievement and publication of meaningful scientific results, which is the main purpose of the present paper.	true	true	true	true	true	1,606
6	DISCUSSION	0	null	null	16,936,310	NA\|NA	The validity of its application is proven via the identification of clusters of common sequences in a group of genes related by their specific expression in the lineage.	null	169	10,045	0	false	null	null	The validity of its application is proven via the identification of clusters of common sequences in a group of genes related by their specific expression in the lineage.	true	true	true	true	true	1,606
6	DISCUSSION	0	null	null	16,936,310	NA\|NA	These sequences have been identified here for the first time.	null	61	10,046	0	false	null	null	These sequences have been identified here for the first time.	true	true	true	true	true	1,606
7	DISCUSSION	0	null	null	16,936,310	null	Comment: The evolving software is available from the authors on request.	null	72	10,047	0	false	null	null	Comment: The evolving software is available from the authors on request.	true	true	true	true	true	1,607
0	INTRODUCTION	1	1–5	[ "B1 B2 B3 B4 B5", "B5 B6 B7", "B6", "B8 B9 B10", "B3", "B11 B12 B13 B14", "B15 B16 B17", "B4", "B5", "B9", "B18 B19 B20", "B21", "B22", "B22", "B23" ]	17,403,694	pmid-14637252\|pmid-10358044\|pmid-9108029\|pmid-15706084\|pmid-11018583\|pmid-11018583\|pmid-9560228\|pmid-9766671\|pmid-9560228\|pmid-7800476\|pmid-9495540\|pmid-12186795\|pmid-9108029\|pmid-9407949\|pmid-10023679\|pmid-14633989\|pmid-11554453\|pmid-8521399\|pmid-9870152\|pmid-7534193\|pmid-15706084\|pmid-11018583\|pmid-9495540\|pmid-10828...	Human apurinic/apyrimidinic endonuclease 1/redox effector factor-1 (APE1/Ref-1) is a bifunctional oxidative-stress-responsive protein (1–5).	[ "1–5", "5–7", "6", "8–10", "3", "11–14", "15–17", "4", "5", "9", "18–20", "21", "22", "22", "23" ]	140	10,048	1	false	Human apurinic/apyrimidinic endonuclease 1/redox effector factor-1 (APE1/Ref-1) is a bifunctional oxidative-stress-responsive protein.	[ "1–5" ]	Human apurinic/apyrimidinic endonuclease 1/redox effector factor-1 is a bifunctional oxidative-stress-responsive protein.	true	true	true	true	true	1,608
0	INTRODUCTION	1	1–5	[ "B1 B2 B3 B4 B5", "B5 B6 B7", "B6", "B8 B9 B10", "B3", "B11 B12 B13 B14", "B15 B16 B17", "B4", "B5", "B9", "B18 B19 B20", "B21", "B22", "B22", "B23" ]	17,403,694	pmid-14637252\|pmid-10358044\|pmid-9108029\|pmid-15706084\|pmid-11018583\|pmid-11018583\|pmid-9560228\|pmid-9766671\|pmid-9560228\|pmid-7800476\|pmid-9495540\|pmid-12186795\|pmid-9108029\|pmid-9407949\|pmid-10023679\|pmid-14633989\|pmid-11554453\|pmid-8521399\|pmid-9870152\|pmid-7534193\|pmid-15706084\|pmid-11018583\|pmid-9495540\|pmid-10828...	On one hand, it acts as an apurinic/apyrimidinic endonuclease, during the second step of the DNA base excision repair pathway, which is responsible for the repair of cellular oxidative DNA damages.	[ "1–5", "5–7", "6", "8–10", "3", "11–14", "15–17", "4", "5", "9", "18–20", "21", "22", "22", "23" ]	197	10,049	0	false	On one hand, it acts as an apurinic/apyrimidinic endonuclease, during the second step of the DNA base excision repair pathway, which is responsible for the repair of cellular oxidative DNA damages.	[]	On one hand, it acts as an apurinic/apyrimidinic endonuclease, during the second step of the DNA base excision repair pathway, which is responsible for the repair of cellular oxidative DNA damages.	true	true	true	true	true	1,608
0	INTRODUCTION	1	1–5	[ "B1 B2 B3 B4 B5", "B5 B6 B7", "B6", "B8 B9 B10", "B3", "B11 B12 B13 B14", "B15 B16 B17", "B4", "B5", "B9", "B18 B19 B20", "B21", "B22", "B22", "B23" ]	17,403,694	pmid-14637252\|pmid-10358044\|pmid-9108029\|pmid-15706084\|pmid-11018583\|pmid-11018583\|pmid-9560228\|pmid-9766671\|pmid-9560228\|pmid-7800476\|pmid-9495540\|pmid-12186795\|pmid-9108029\|pmid-9407949\|pmid-10023679\|pmid-14633989\|pmid-11554453\|pmid-8521399\|pmid-9870152\|pmid-7534193\|pmid-15706084\|pmid-11018583\|pmid-9495540\|pmid-10828...	On the other hand, it plays a crucial role, as a coactivator for various transcription factors in controlling gene expression by redox-dependent mechanism.	[ "1–5", "5–7", "6", "8–10", "3", "11–14", "15–17", "4", "5", "9", "18–20", "21", "22", "22", "23" ]	155	10,050	0	false	On the other hand, it plays a crucial role, as a coactivator for various transcription factors in controlling gene expression by redox-dependent mechanism.	[]	On the other hand, it plays a crucial role, as a coactivator for various transcription factors in controlling gene expression by redox-dependent mechanism.	true	true	true	true	true	1,608
0	INTRODUCTION	1	5–7	[ "B1 B2 B3 B4 B5", "B5 B6 B7", "B6", "B8 B9 B10", "B3", "B11 B12 B13 B14", "B15 B16 B17", "B4", "B5", "B9", "B18 B19 B20", "B21", "B22", "B22", "B23" ]	17,403,694	pmid-14637252\|pmid-10358044\|pmid-9108029\|pmid-15706084\|pmid-11018583\|pmid-11018583\|pmid-9560228\|pmid-9766671\|pmid-9560228\|pmid-7800476\|pmid-9495540\|pmid-12186795\|pmid-9108029\|pmid-9407949\|pmid-10023679\|pmid-14633989\|pmid-11554453\|pmid-8521399\|pmid-9870152\|pmid-7534193\|pmid-15706084\|pmid-11018583\|pmid-9495540\|pmid-10828...	Therefore, the regulation of APE1 function is a very important issue (5–7).	[ "1–5", "5–7", "6", "8–10", "3", "11–14", "15–17", "4", "5", "9", "18–20", "21", "22", "22", "23" ]	75	10,051	1	false	Therefore, the regulation of APE1 function is a very important issue.	[ "5–7" ]	Therefore, the regulation of APE1 function is a very important issue.	true	true	true	true	true	1,608
0	INTRODUCTION	1	1–5	[ "B1 B2 B3 B4 B5", "B5 B6 B7", "B6", "B8 B9 B10", "B3", "B11 B12 B13 B14", "B15 B16 B17", "B4", "B5", "B9", "B18 B19 B20", "B21", "B22", "B22", "B23" ]	17,403,694	pmid-14637252\|pmid-10358044\|pmid-9108029\|pmid-15706084\|pmid-11018583\|pmid-11018583\|pmid-9560228\|pmid-9766671\|pmid-9560228\|pmid-7800476\|pmid-9495540\|pmid-12186795\|pmid-9108029\|pmid-9407949\|pmid-10023679\|pmid-14633989\|pmid-11554453\|pmid-8521399\|pmid-9870152\|pmid-7534193\|pmid-15706084\|pmid-11018583\|pmid-9495540\|pmid-10828...	The cellular function of APE1 is coordinately controlled at several levels.	[ "1–5", "5–7", "6", "8–10", "3", "11–14", "15–17", "4", "5", "9", "18–20", "21", "22", "22", "23" ]	75	10,052	0	false	The cellular function of APE1 is coordinately controlled at several levels.	[]	The cellular function of APE1 is coordinately controlled at several levels.	true	true	true	true	true	1,608
0	INTRODUCTION	1	1–5	[ "B1 B2 B3 B4 B5", "B5 B6 B7", "B6", "B8 B9 B10", "B3", "B11 B12 B13 B14", "B15 B16 B17", "B4", "B5", "B9", "B18 B19 B20", "B21", "B22", "B22", "B23" ]	17,403,694	pmid-14637252\|pmid-10358044\|pmid-9108029\|pmid-15706084\|pmid-11018583\|pmid-11018583\|pmid-9560228\|pmid-9766671\|pmid-9560228\|pmid-7800476\|pmid-9495540\|pmid-12186795\|pmid-9108029\|pmid-9407949\|pmid-10023679\|pmid-14633989\|pmid-11554453\|pmid-8521399\|pmid-9870152\|pmid-7534193\|pmid-15706084\|pmid-11018583\|pmid-9495540\|pmid-10828...	Firstly, the expression of APE1 can be upregulated by a variety of reactive oxygen species (ROS) and ROS-generating systems (6,8–10).	[ "1–5", "5–7", "6", "8–10", "3", "11–14", "15–17", "4", "5", "9", "18–20", "21", "22", "22", "23" ]	133	10,053	0	false	Firstly, the expression of APE1 can be upregulated by a variety of reactive oxygen species (ROS) and ROS-generating systems.	[ "6,8–10" ]	Firstly, the expression of APE1 can be upregulated by a variety of reactive oxygen species (ROS) and ROS-generating systems.	true	true	true	true	true	1,608
0	INTRODUCTION	1	1–5	[ "B1 B2 B3 B4 B5", "B5 B6 B7", "B6", "B8 B9 B10", "B3", "B11 B12 B13 B14", "B15 B16 B17", "B4", "B5", "B9", "B18 B19 B20", "B21", "B22", "B22", "B23" ]	17,403,694	pmid-14637252\|pmid-10358044\|pmid-9108029\|pmid-15706084\|pmid-11018583\|pmid-11018583\|pmid-9560228\|pmid-9766671\|pmid-9560228\|pmid-7800476\|pmid-9495540\|pmid-12186795\|pmid-9108029\|pmid-9407949\|pmid-10023679\|pmid-14633989\|pmid-11554453\|pmid-8521399\|pmid-9870152\|pmid-7534193\|pmid-15706084\|pmid-11018583\|pmid-9495540\|pmid-10828...	Secondly, APE1 can be modified by phosphorylation, acetylation, and redox modification, which are important for the regulation of its DNA-binding, transcriptional regulation, and DNA repair functions (3,11–14).	[ "1–5", "5–7", "6", "8–10", "3", "11–14", "15–17", "4", "5", "9", "18–20", "21", "22", "22", "23" ]	210	10,054	0	false	Secondly, APE1 can be modified by phosphorylation, acetylation, and redox modification, which are important for the regulation of its DNA-binding, transcriptional regulation, and DNA repair functions.	[ "3,11–14" ]	Secondly, APE1 can be modified by phosphorylation, acetylation, and redox modification, which are important for the regulation of its DNA-binding, transcriptional regulation, and DNA repair functions.	true	true	true	true	true	1,608
0	INTRODUCTION	1	1–5	[ "B1 B2 B3 B4 B5", "B5 B6 B7", "B6", "B8 B9 B10", "B3", "B11 B12 B13 B14", "B15 B16 B17", "B4", "B5", "B9", "B18 B19 B20", "B21", "B22", "B22", "B23" ]	17,403,694	pmid-14637252\|pmid-10358044\|pmid-9108029\|pmid-15706084\|pmid-11018583\|pmid-11018583\|pmid-9560228\|pmid-9766671\|pmid-9560228\|pmid-7800476\|pmid-9495540\|pmid-12186795\|pmid-9108029\|pmid-9407949\|pmid-10023679\|pmid-14633989\|pmid-11554453\|pmid-8521399\|pmid-9870152\|pmid-7534193\|pmid-15706084\|pmid-11018583\|pmid-9495540\|pmid-10828...	Lastly, the APE1 subcellular distribution varies according to different cell types and environment stresses.	[ "1–5", "5–7", "6", "8–10", "3", "11–14", "15–17", "4", "5", "9", "18–20", "21", "22", "22", "23" ]	108	10,055	0	false	Lastly, the APE1 subcellular distribution varies according to different cell types and environment stresses.	[]	Lastly, the APE1 subcellular distribution varies according to different cell types and environment stresses.	true	true	true	true	true	1,608
0	INTRODUCTION	1	15–17	[ "B1 B2 B3 B4 B5", "B5 B6 B7", "B6", "B8 B9 B10", "B3", "B11 B12 B13 B14", "B15 B16 B17", "B4", "B5", "B9", "B18 B19 B20", "B21", "B22", "B22", "B23" ]	17,403,694	pmid-14637252\|pmid-10358044\|pmid-9108029\|pmid-15706084\|pmid-11018583\|pmid-11018583\|pmid-9560228\|pmid-9766671\|pmid-9560228\|pmid-7800476\|pmid-9495540\|pmid-12186795\|pmid-9108029\|pmid-9407949\|pmid-10023679\|pmid-14633989\|pmid-11554453\|pmid-8521399\|pmid-9870152\|pmid-7534193\|pmid-15706084\|pmid-11018583\|pmid-9495540\|pmid-10828...	(1) The expression pattern of APE1 is mainly nuclear, but cytoplasmic staining has also been reported (15–17).	[ "1–5", "5–7", "6", "8–10", "3", "11–14", "15–17", "4", "5", "9", "18–20", "21", "22", "22", "23" ]	110	10,056	1	false	(1) The expression pattern of APE1 is mainly nuclear, but cytoplasmic staining has also been reported.	[ "15–17" ]	The expression pattern of APE1 is mainly nuclear, but cytoplasmic staining has also been reported.	true	true	true	true	true	1,608
0	INTRODUCTION	1	1–5	[ "B1 B2 B3 B4 B5", "B5 B6 B7", "B6", "B8 B9 B10", "B3", "B11 B12 B13 B14", "B15 B16 B17", "B4", "B5", "B9", "B18 B19 B20", "B21", "B22", "B22", "B23" ]	17,403,694	pmid-14637252\|pmid-10358044\|pmid-9108029\|pmid-15706084\|pmid-11018583\|pmid-11018583\|pmid-9560228\|pmid-9766671\|pmid-9560228\|pmid-7800476\|pmid-9495540\|pmid-12186795\|pmid-9108029\|pmid-9407949\|pmid-10023679\|pmid-14633989\|pmid-11554453\|pmid-8521399\|pmid-9870152\|pmid-7534193\|pmid-15706084\|pmid-11018583\|pmid-9495540\|pmid-10828...	The latter is usually observed in highly metabolically active or proliferative cells, which may experience an increased oxidative stress (4,5).	[ "1–5", "5–7", "6", "8–10", "3", "11–14", "15–17", "4", "5", "9", "18–20", "21", "22", "22", "23" ]	143	10,057	0	false	The latter is usually observed in highly metabolically active or proliferative cells, which may experience an increased oxidative stress.	[ "4,5" ]	The latter is usually observed in highly metabolically active or proliferative cells, which may experience an increased oxidative stress.	true	true	true	true	true	1,608
0	INTRODUCTION	1	1–5	[ "B1 B2 B3 B4 B5", "B5 B6 B7", "B6", "B8 B9 B10", "B3", "B11 B12 B13 B14", "B15 B16 B17", "B4", "B5", "B9", "B18 B19 B20", "B21", "B22", "B22", "B23" ]	17,403,694	pmid-14637252\|pmid-10358044\|pmid-9108029\|pmid-15706084\|pmid-11018583\|pmid-11018583\|pmid-9560228\|pmid-9766671\|pmid-9560228\|pmid-7800476\|pmid-9495540\|pmid-12186795\|pmid-9108029\|pmid-9407949\|pmid-10023679\|pmid-14633989\|pmid-11554453\|pmid-8521399\|pmid-9870152\|pmid-7534193\|pmid-15706084\|pmid-11018583\|pmid-9495540\|pmid-10828...	(2) Generally, stimuli that induce APE1 expression are also able to promote its intracellular movement.	[ "1–5", "5–7", "6", "8–10", "3", "11–14", "15–17", "4", "5", "9", "18–20", "21", "22", "22", "23" ]	103	10,058	0	false	(2) Generally, stimuli that induce APE1 expression are also able to promote its intracellular movement.	[]	(2) Generally, stimuli that induce APE1 expression are also able to promote its intracellular movement.	false	false	true	true	false	1,608
0	INTRODUCTION	1	1–5	[ "B1 B2 B3 B4 B5", "B5 B6 B7", "B6", "B8 B9 B10", "B3", "B11 B12 B13 B14", "B15 B16 B17", "B4", "B5", "B9", "B18 B19 B20", "B21", "B22", "B22", "B23" ]	17,403,694	pmid-14637252\|pmid-10358044\|pmid-9108029\|pmid-15706084\|pmid-11018583\|pmid-11018583\|pmid-9560228\|pmid-9766671\|pmid-9560228\|pmid-7800476\|pmid-9495540\|pmid-12186795\|pmid-9108029\|pmid-9407949\|pmid-10023679\|pmid-14633989\|pmid-11554453\|pmid-8521399\|pmid-9870152\|pmid-7534193\|pmid-15706084\|pmid-11018583\|pmid-9495540\|pmid-10828...	Various redox-related stimuli can induce the translocation of APE1 from cytoplasm to nucleus (9,18–20).	[ "1–5", "5–7", "6", "8–10", "3", "11–14", "15–17", "4", "5", "9", "18–20", "21", "22", "22", "23" ]	103	10,059	0	false	Various redox-related stimuli can induce the translocation of APE1 from cytoplasm to nucleus.	[ "9,18–20" ]	Various redox-related stimuli can induce the translocation of APE1 from cytoplasm to nucleus.	true	true	true	true	true	1,608
0	INTRODUCTION	1	21	[ "B1 B2 B3 B4 B5", "B5 B6 B7", "B6", "B8 B9 B10", "B3", "B11 B12 B13 B14", "B15 B16 B17", "B4", "B5", "B9", "B18 B19 B20", "B21", "B22", "B22", "B23" ]	17,403,694	pmid-14637252\|pmid-10358044\|pmid-9108029\|pmid-15706084\|pmid-11018583\|pmid-11018583\|pmid-9560228\|pmid-9766671\|pmid-9560228\|pmid-7800476\|pmid-9495540\|pmid-12186795\|pmid-9108029\|pmid-9407949\|pmid-10023679\|pmid-14633989\|pmid-11554453\|pmid-8521399\|pmid-9870152\|pmid-7534193\|pmid-15706084\|pmid-11018583\|pmid-9495540\|pmid-10828...	The nuclear import process may be dependent on an N-terminal nuclear import sequence (NLS) that mediates the importin-dependent nuclear import of APE1 (21).	[ "1–5", "5–7", "6", "8–10", "3", "11–14", "15–17", "4", "5", "9", "18–20", "21", "22", "22", "23" ]	156	10,060	1	false	The nuclear import process may be dependent on an N-terminal nuclear import sequence (NLS) that mediates the importin-dependent nuclear import of APE1.	[ "21" ]	The nuclear import process may be dependent on an N-terminal nuclear import sequence (NLS) that mediates the importin-dependent nuclear import of APE1.	true	true	true	true	true	1,608
0	INTRODUCTION	1	22	[ "B1 B2 B3 B4 B5", "B5 B6 B7", "B6", "B8 B9 B10", "B3", "B11 B12 B13 B14", "B15 B16 B17", "B4", "B5", "B9", "B18 B19 B20", "B21", "B22", "B22", "B23" ]	17,403,694	pmid-14637252\|pmid-10358044\|pmid-9108029\|pmid-15706084\|pmid-11018583\|pmid-11018583\|pmid-9560228\|pmid-9766671\|pmid-9560228\|pmid-7800476\|pmid-9495540\|pmid-12186795\|pmid-9108029\|pmid-9407949\|pmid-10023679\|pmid-14633989\|pmid-11554453\|pmid-8521399\|pmid-9870152\|pmid-7534193\|pmid-15706084\|pmid-11018583\|pmid-9495540\|pmid-10828...	In B-lymphocyte, H2O2 stimulation can induce a relocalization of APE1 into mitochondria (22).	[ "1–5", "5–7", "6", "8–10", "3", "11–14", "15–17", "4", "5", "9", "18–20", "21", "22", "22", "23" ]	93	10,061	1	false	In B-lymphocyte, H2O2 stimulation can induce a relocalization of APE1 into mitochondria.	[ "22" ]	In B-lymphocyte, H2O2 stimulation can induce a relocalization of APE1 into mitochondria.	true	true	true	true	true	1,608
0	INTRODUCTION	1	1–5	[ "B1 B2 B3 B4 B5", "B5 B6 B7", "B6", "B8 B9 B10", "B3", "B11 B12 B13 B14", "B15 B16 B17", "B4", "B5", "B9", "B18 B19 B20", "B21", "B22", "B22", "B23" ]	17,403,694	pmid-14637252\|pmid-10358044\|pmid-9108029\|pmid-15706084\|pmid-11018583\|pmid-11018583\|pmid-9560228\|pmid-9766671\|pmid-9560228\|pmid-7800476\|pmid-9495540\|pmid-12186795\|pmid-9108029\|pmid-9407949\|pmid-10023679\|pmid-14633989\|pmid-11554453\|pmid-8521399\|pmid-9870152\|pmid-7534193\|pmid-15706084\|pmid-11018583\|pmid-9495540\|pmid-10828...	Recently, a low abundance of mitochondrial-localized APE1 was found as the N-terminal 33 residues-truncated form (22,23).	[ "1–5", "5–7", "6", "8–10", "3", "11–14", "15–17", "4", "5", "9", "18–20", "21", "22", "22", "23" ]	121	10,062	0	false	Recently, a low abundance of mitochondrial-localized APE1 was found as the N-terminal 33 residues-truncated form.	[ "22,23" ]	Recently, a low abundance of mitochondrial-localized APE1 was found as the N-terminal 33 residues-truncated form.	true	true	true	true	true	1,608
0	INTRODUCTION	1	1–5	[ "B1 B2 B3 B4 B5", "B5 B6 B7", "B6", "B8 B9 B10", "B3", "B11 B12 B13 B14", "B15 B16 B17", "B4", "B5", "B9", "B18 B19 B20", "B21", "B22", "B22", "B23" ]	17,403,694	pmid-14637252\|pmid-10358044\|pmid-9108029\|pmid-15706084\|pmid-11018583\|pmid-11018583\|pmid-9560228\|pmid-9766671\|pmid-9560228\|pmid-7800476\|pmid-9495540\|pmid-12186795\|pmid-9108029\|pmid-9407949\|pmid-10023679\|pmid-14633989\|pmid-11554453\|pmid-8521399\|pmid-9870152\|pmid-7534193\|pmid-15706084\|pmid-11018583\|pmid-9495540\|pmid-10828...	Although various subcellular localizations and intracellular trafficking of APE1 have been reported, little is known about how these phenomena are regulated.	[ "1–5", "5–7", "6", "8–10", "3", "11–14", "15–17", "4", "5", "9", "18–20", "21", "22", "22", "23" ]	157	10,063	0	false	Although various subcellular localizations and intracellular trafficking of APE1 have been reported, little is known about how these phenomena are regulated.	[]	Although various subcellular localizations and intracellular trafficking of APE1 have been reported, little is known about how these phenomena are regulated.	true	true	true	true	true	1,608
0	INTRODUCTION	1	1–5	[ "B1 B2 B3 B4 B5", "B5 B6 B7", "B6", "B8 B9 B10", "B3", "B11 B12 B13 B14", "B15 B16 B17", "B4", "B5", "B9", "B18 B19 B20", "B21", "B22", "B22", "B23" ]	17,403,694	pmid-14637252\|pmid-10358044\|pmid-9108029\|pmid-15706084\|pmid-11018583\|pmid-11018583\|pmid-9560228\|pmid-9766671\|pmid-9560228\|pmid-7800476\|pmid-9495540\|pmid-12186795\|pmid-9108029\|pmid-9407949\|pmid-10023679\|pmid-14633989\|pmid-11554453\|pmid-8521399\|pmid-9870152\|pmid-7534193\|pmid-15706084\|pmid-11018583\|pmid-9495540\|pmid-10828...	Particularly, the mechanism of the redox regulated localization change remains open.	[ "1–5", "5–7", "6", "8–10", "3", "11–14", "15–17", "4", "5", "9", "18–20", "21", "22", "22", "23" ]	84	10,064	0	false	Particularly, the mechanism of the redox regulated localization change remains open.	[]	Particularly, the mechanism of the redox regulated localization change remains open.	true	true	true	true	true	1,608
1	INTRODUCTION	1	24–27	[ "B24 B25 B26 B27", "B28", "B29", "B30", "B4" ]	17,403,694	pmid-16878402\|pmid-16601461\|pmid-15688001\|pmid-7923362\|pmid-11023973\|pmid-10646872\|pmid-15951807\|pmid-15706084	Nitric oxide (NO) is a reactive free radical that plays a central role in diverse signaling pathways (24–27).	[ "24–27", "28", "29", "30", "4" ]	109	10,065	1	false	Nitric oxide (NO) is a reactive free radical that plays a central role in diverse signaling pathways.	[ "24–27" ]	Nitric oxide (NO) is a reactive free radical that plays a central role in diverse signaling pathways.	true	true	true	true	true	1,609
1	INTRODUCTION	1	24–27	[ "B24 B25 B26 B27", "B28", "B29", "B30", "B4" ]	17,403,694	pmid-16878402\|pmid-16601461\|pmid-15688001\|pmid-7923362\|pmid-11023973\|pmid-10646872\|pmid-15951807\|pmid-15706084	Apart from the well-known cGMP-dependent signaling pathway of NO, there is also a cGMP-independent pathway that involves protein S-nitrosation.	[ "24–27", "28", "29", "30", "4" ]	143	10,066	0	false	Apart from the well-known cGMP-dependent signaling pathway of NO, there is also a cGMP-independent pathway that involves protein S-nitrosation.	[]	Apart from the well-known cGMP-dependent signaling pathway of NO, there is also a cGMP-independent pathway that involves protein S-nitrosation.	true	true	true	true	true	1,609
1	INTRODUCTION	1	24–27	[ "B24 B25 B26 B27", "B28", "B29", "B30", "B4" ]	17,403,694	pmid-16878402\|pmid-16601461\|pmid-15688001\|pmid-7923362\|pmid-11023973\|pmid-10646872\|pmid-15951807\|pmid-15706084	S-nitrosation is a ubiquitous redox-related modification of cysteine thiols by nitric oxide, which transduces the bioactivity of NO.	[ "24–27", "28", "29", "30", "4" ]	132	10,067	0	false	S-nitrosation is a ubiquitous redox-related modification of cysteine thiols by nitric oxide, which transduces the bioactivity of NO.	[]	S-nitrosation is a ubiquitous redox-related modification of cysteine thiols by nitric oxide, which transduces the bioactivity of NO.	true	true	true	true	true	1,609
1	INTRODUCTION	1	28	[ "B24 B25 B26 B27", "B28", "B29", "B30", "B4" ]	17,403,694	pmid-16878402\|pmid-16601461\|pmid-15688001\|pmid-7923362\|pmid-11023973\|pmid-10646872\|pmid-15951807\|pmid-15706084	S-nitrosation has been implicated in regulation of gene transcription (28), enzyme activity (29), and protein nuclear translocation (30).	[ "24–27", "28", "29", "30", "4" ]	137	10,068	1	false	S-nitrosation has been implicated in regulation of gene transcription, enzyme activity, and protein nuclear translocation.	[ "28", "29", "30" ]	S-nitrosation has been implicated in regulation of gene transcription, enzyme activity, and protein nuclear translocation.	true	true	true	true	true	1,609
1	INTRODUCTION	1	4	[ "B24 B25 B26 B27", "B28", "B29", "B30", "B4" ]	17,403,694	pmid-16878402\|pmid-16601461\|pmid-15688001\|pmid-7923362\|pmid-11023973\|pmid-10646872\|pmid-15951807\|pmid-15706084	APE1 contains a redox-active domain and three redox-sensitive cysteine residues, and its subcellular localization seems redox-sensitive (4).	[ "24–27", "28", "29", "30", "4" ]	140	10,069	1	false	APE1 contains a redox-active domain and three redox-sensitive cysteine residues, and its subcellular localization seems redox-sensitive.	[ "4" ]	APE1 contains a redox-active domain and three redox-sensitive cysteine residues, and its subcellular localization seems redox-sensitive.	true	true	true	true	true	1,609
1	INTRODUCTION	1	24–27	[ "B24 B25 B26 B27", "B28", "B29", "B30", "B4" ]	17,403,694	pmid-16878402\|pmid-16601461\|pmid-15688001\|pmid-7923362\|pmid-11023973\|pmid-10646872\|pmid-15951807\|pmid-15706084	However, whether APE1 can be modified by NO-elicited S-nitrosation and whether its subcellular distribution can be regulated by this redox modification have not been reported.	[ "24–27", "28", "29", "30", "4" ]	175	10,070	0	false	However, whether APE1 can be modified by NO-elicited S-nitrosation and whether its subcellular distribution can be regulated by this redox modification have not been reported.	[]	However, whether APE1 can be modified by NO-elicited S-nitrosation and whether its subcellular distribution can be regulated by this redox modification have not been reported.	true	true	true	true	true	1,609
2	INTRODUCTION	0	null	null	17,403,694	pmid-9628873	In this study, we reported that APE1 can inducibly translocate from nucleus to cytoplasm in response to nitric oxide stimulation in a CRM1-independent manner.	null	158	10,071	0	false	null	null	In this study, we reported that APE1 can inducibly translocate from nucleus to cytoplasm in response to nitric oxide stimulation in a CRM1-independent manner.	true	true	true	true	true	1,610
2	INTRODUCTION	0	null	null	17,403,694	pmid-9628873	This nuclear export process of APE1 is reversible and dependent on the S-nitrosation of its Cys93 and Cys310 sites.	null	115	10,072	0	false	null	null	This nuclear export process of APE1 is reversible and dependent on the S-nitrosation of its Cys93 and Cys310 sites.	true	true	true	true	true	1,610
2	INTRODUCTION	0	null	null	17,403,694	pmid-9628873	In structure, two antiparallel beta-strands close to Cys93 and Cys310 were identified to be required for NO-mediated export of APE1.	null	132	10,073	0	false	null	null	In structure, two antiparallel beta-strands close to Cys93 and Cys310 were identified to be required for NO-mediated export of APE1.	true	true	true	true	true	1,610
2	INTRODUCTION	0	null	null	17,403,694	pmid-9628873	In addition, it was found that the importin-mediated nuclear import pathway was repressed in NO-insulted cells, which may prevent cytosolic APE1 from re-transporting into the nucleus.	null	183	10,074	0	false	null	null	In addition, it was found that the importin-mediated nuclear import pathway was repressed in NO-insulted cells, which may prevent cytosolic APE1 from re-transporting into the nucleus.	true	true	true	true	true	1,610
2	INTRODUCTION	0	null	null	17,403,694	pmid-9628873	Thus, we for the first time reveal a molecular event that coordinates S-nitrosation modification and nuclear-cytosolic shuttling of APE1.	null	137	10,075	0	false	null	null	Thus, we for the first time reveal a molecular event that coordinates S-nitrosation modification and nuclear-cytosolic shuttling of APE1.	true	true	true	true	true	1,610
2	INTRODUCTION	0	null	null	17,403,694	pmid-9628873	Since the disruption of APE1 subcellular localization may result in a defect in intra-nuclear DNA repair and transcriptional regulation functions, this finding may establish a novel role of APE1 in NO-related physiological and pathological processes.	null	250	10,076	0	false	null	null	Since the disruption of APE1 subcellular localization may result in a defect in intra-nuclear DNA repair and transcriptional regulation functions, this finding may establish a novel role of APE1 in NO-related physiological and pathological processes.	true	true	true	true	true	1,610
0	DISCUSSION	1	26	[ "B26", "B51", "B52", "B53", "B54", "B55", "B12", "B13", "B56" ]	17,403,694	pmid-14637252\|pmid-10358044\|pmid-9108029\|pmid-15706084\|pmid-11018583\|pmid-11018583\|pmid-9560228\|pmid-9766671\|pmid-9560228\|pmid-7800476\|pmid-9495540\|pmid-12186795\|pmid-9108029\|pmid-9407949\|pmid-10023679\|pmid-14633989\|pmid-11554453\|pmid-8521399\|pmid-9870152\|pmid-7534193\|pmid-15706084\|pmid-11018583\|pmid-9495540\|pmid-10828...	Post-translational protein modification is a crucial mechanism to regulate protein function in eukaryotic cells.	[ "26", "51", "52", "53", "54", "55", "12", "13", "56" ]	112	10,077	0	false	Post-translational protein modification is a crucial mechanism to regulate protein function in eukaryotic cells.	[]	Post-translational protein modification is a crucial mechanism to regulate protein function in eukaryotic cells.	true	true	true	true	true	1,611
0	DISCUSSION	1	26	[ "B26", "B51", "B52", "B53", "B54", "B55", "B12", "B13", "B56" ]	17,403,694	pmid-14637252\|pmid-10358044\|pmid-9108029\|pmid-15706084\|pmid-11018583\|pmid-11018583\|pmid-9560228\|pmid-9766671\|pmid-9560228\|pmid-7800476\|pmid-9495540\|pmid-12186795\|pmid-9108029\|pmid-9407949\|pmid-10023679\|pmid-14633989\|pmid-11554453\|pmid-8521399\|pmid-9870152\|pmid-7534193\|pmid-15706084\|pmid-11018583\|pmid-9495540\|pmid-10828...	Similar to other post-translational modifications, protein S-nitrosation exerts pleiotropic effects on its target proteins, ranging from altered protein stabilization to changed activity or function (26).	[ "26", "51", "52", "53", "54", "55", "12", "13", "56" ]	204	10,078	1	false	Similar to other post-translational modifications, protein S-nitrosation exerts pleiotropic effects on its target proteins, ranging from altered protein stabilization to changed activity or function.	[ "26" ]	Similar to other post-translational modifications, protein S-nitrosation exerts pleiotropic effects on its target proteins, ranging from altered protein stabilization to changed activity or function.	true	true	true	true	true	1,611
0	DISCUSSION	1	26	[ "B26", "B51", "B52", "B53", "B54", "B55", "B12", "B13", "B56" ]	17,403,694	pmid-14637252\|pmid-10358044\|pmid-9108029\|pmid-15706084\|pmid-11018583\|pmid-11018583\|pmid-9560228\|pmid-9766671\|pmid-9560228\|pmid-7800476\|pmid-9495540\|pmid-12186795\|pmid-9108029\|pmid-9407949\|pmid-10023679\|pmid-14633989\|pmid-11554453\|pmid-8521399\|pmid-9870152\|pmid-7534193\|pmid-15706084\|pmid-11018583\|pmid-9495540\|pmid-10828...	Recently, Hara et al.	[ "26", "51", "52", "53", "54", "55", "12", "13", "56" ]	21	10,079	0	false	Recently, Hara et al.	[]	Recently, Hara et al.	true	true	true	true	true	1,611
0	DISCUSSION	1	26	[ "B26", "B51", "B52", "B53", "B54", "B55", "B12", "B13", "B56" ]	17,403,694	pmid-14637252\|pmid-10358044\|pmid-9108029\|pmid-15706084\|pmid-11018583\|pmid-11018583\|pmid-9560228\|pmid-9766671\|pmid-9560228\|pmid-7800476\|pmid-9495540\|pmid-12186795\|pmid-9108029\|pmid-9407949\|pmid-10023679\|pmid-14633989\|pmid-11554453\|pmid-8521399\|pmid-9870152\|pmid-7534193\|pmid-15706084\|pmid-11018583\|pmid-9495540\|pmid-10828...	reported that S-nitrosation mediated nuclear translocation of GAPDH.	[ "26", "51", "52", "53", "54", "55", "12", "13", "56" ]	68	10,080	0	false	reported that S-nitrosation mediated nuclear translocation of GAPDH.	[]	reported that S-nitrosation mediated nuclear translocation of GAPDH.	false	true	true	true	false	1,611
0	DISCUSSION	1	26	[ "B26", "B51", "B52", "B53", "B54", "B55", "B12", "B13", "B56" ]	17,403,694	pmid-14637252\|pmid-10358044\|pmid-9108029\|pmid-15706084\|pmid-11018583\|pmid-11018583\|pmid-9560228\|pmid-9766671\|pmid-9560228\|pmid-7800476\|pmid-9495540\|pmid-12186795\|pmid-9108029\|pmid-9407949\|pmid-10023679\|pmid-14633989\|pmid-11554453\|pmid-8521399\|pmid-9870152\|pmid-7534193\|pmid-15706084\|pmid-11018583\|pmid-9495540\|pmid-10828...	In the current investigation, we revealed that S-nitrosation mediated nuclear export of APE1.	[ "26", "51", "52", "53", "54", "55", "12", "13", "56" ]	93	10,081	0	false	In the current investigation, we revealed that S-nitrosation mediated nuclear export of APE1.	[]	In the current investigation, we revealed that S-nitrosation mediated nuclear export of APE1.	true	true	true	true	true	1,611
0	DISCUSSION	1	51	[ "B26", "B51", "B52", "B53", "B54", "B55", "B12", "B13", "B56" ]	17,403,694	pmid-14637252\|pmid-10358044\|pmid-9108029\|pmid-15706084\|pmid-11018583\|pmid-11018583\|pmid-9560228\|pmid-9766671\|pmid-9560228\|pmid-7800476\|pmid-9495540\|pmid-12186795\|pmid-9108029\|pmid-9407949\|pmid-10023679\|pmid-14633989\|pmid-11554453\|pmid-8521399\|pmid-9870152\|pmid-7534193\|pmid-15706084\|pmid-11018583\|pmid-9495540\|pmid-10828...	To our knowledge, this is the first evidence that S-nitrosation modification is able to control protein nuclear export, although other post-translational modifications, including phosphorylation (51), ubiquitination (52), sumoylation (53), acetylation (54), and thiol modification (55) have already been involved in such...	[ "26", "51", "52", "53", "54", "55", "12", "13", "56" ]	331	10,082	1	false	To our knowledge, this is the first evidence that S-nitrosation modification is able to control protein nuclear export, although other post-translational modifications, including phosphorylation, ubiquitination, sumoylation, acetylation, and thiol modification have already been involved in such processes.	[ "51", "52", "53", "54", "55" ]	To our knowledge, this is the first evidence that S-nitrosation modification is able to control protein nuclear export, although other post-translational modifications, including phosphorylation, ubiquitination, sumoylation, acetylation, and thiol modification have already been involved in such processes.	true	true	true	true	true	1,611
0	DISCUSSION	1	26	[ "B26", "B51", "B52", "B53", "B54", "B55", "B12", "B13", "B56" ]	17,403,694	pmid-14637252\|pmid-10358044\|pmid-9108029\|pmid-15706084\|pmid-11018583\|pmid-11018583\|pmid-9560228\|pmid-9766671\|pmid-9560228\|pmid-7800476\|pmid-9495540\|pmid-12186795\|pmid-9108029\|pmid-9407949\|pmid-10023679\|pmid-14633989\|pmid-11554453\|pmid-8521399\|pmid-9870152\|pmid-7534193\|pmid-15706084\|pmid-11018583\|pmid-9495540\|pmid-10828...	For APE1, to date, the potential phosphorylation sites, acetylation sites, and granzyme A-cleavage sites have been well established, and the modification of these sites have been known to change APE1 activity (12,13,56).	[ "26", "51", "52", "53", "54", "55", "12", "13", "56" ]	220	10,083	0	false	For APE1, to date, the potential phosphorylation sites, acetylation sites, and granzyme A-cleavage sites have been well established, and the modification of these sites have been known to change APE1 activity.	[ "12,13,56" ]	For APE1, to date, the potential phosphorylation sites, acetylation sites, and granzyme A-cleavage sites have been well established, and the modification of these sites have been known to change APE1 activity.	true	true	true	true	true	1,611
0	DISCUSSION	1	26	[ "B26", "B51", "B52", "B53", "B54", "B55", "B12", "B13", "B56" ]	17,403,694	pmid-14637252\|pmid-10358044\|pmid-9108029\|pmid-15706084\|pmid-11018583\|pmid-11018583\|pmid-9560228\|pmid-9766671\|pmid-9560228\|pmid-7800476\|pmid-9495540\|pmid-12186795\|pmid-9108029\|pmid-9407949\|pmid-10023679\|pmid-14633989\|pmid-11554453\|pmid-8521399\|pmid-9870152\|pmid-7534193\|pmid-15706084\|pmid-11018583\|pmid-9495540\|pmid-10828...	However, the potential S-nitrosation sites of APE1 and the effect of this modification on APE1 have not been reported.	[ "26", "51", "52", "53", "54", "55", "12", "13", "56" ]	118	10,084	0	false	However, the potential S-nitrosation sites of APE1 and the effect of this modification on APE1 have not been reported.	[]	However, the potential S-nitrosation sites of APE1 and the effect of this modification on APE1 have not been reported.	true	true	true	true	true	1,611
0	DISCUSSION	1	26	[ "B26", "B51", "B52", "B53", "B54", "B55", "B12", "B13", "B56" ]	17,403,694	pmid-14637252\|pmid-10358044\|pmid-9108029\|pmid-15706084\|pmid-11018583\|pmid-11018583\|pmid-9560228\|pmid-9766671\|pmid-9560228\|pmid-7800476\|pmid-9495540\|pmid-12186795\|pmid-9108029\|pmid-9407949\|pmid-10023679\|pmid-14633989\|pmid-11554453\|pmid-8521399\|pmid-9870152\|pmid-7534193\|pmid-15706084\|pmid-11018583\|pmid-9495540\|pmid-10828...	Our finding also provided the first evidence that nitrosative stress regulated APE1 by subcellular translocation through S-nitrosation mechanism.	[ "26", "51", "52", "53", "54", "55", "12", "13", "56" ]	145	10,085	0	false	Our finding also provided the first evidence that nitrosative stress regulated APE1 by subcellular translocation through S-nitrosation mechanism.	[]	Our finding also provided the first evidence that nitrosative stress regulated APE1 by subcellular translocation through S-nitrosation mechanism.	true	true	true	true	true	1,611
1	DISCUSSION	0	null	null	17,403,694	pmid-16878402\|pmid-16601461\|pmid-15688001\|pmid-7923362\|pmid-11023973\|pmid-10646872\|pmid-15951807\|pmid-15706084	Strikingly, this inducible cytosolic translocation of APE1 is an NO-related phenomenon.	null	87	10,086	0	false	null	null	Strikingly, this inducible cytosolic translocation of APE1 is an NO-related phenomenon.	true	true	true	true	true	1,612
1	DISCUSSION	0	null	null	17,403,694	pmid-16878402\|pmid-16601461\|pmid-15688001\|pmid-7923362\|pmid-11023973\|pmid-10646872\|pmid-15951807\|pmid-15706084	Firstly, the nuclear export of APE1 was not sensitive to other oxidative stresses such as H2O2 (Figure 4A), which may cause a higher oxidative form of APE1, although the possibility has not been excluded that H2O2 may act in a similar manner as NO in the regulation of APE1 trafficking in other unexamined cell types.	null	317	10,087	0	false	null	null	Firstly, the nuclear export of APE1 was not sensitive to other oxidative stresses such as H2O2 (Figure 4A), which may cause a higher oxidative form of APE1, although the possibility has not been excluded that H2O2 may act in a similar manner as NO in the regulation of APE1 trafficking in other unexamined cell types.	true	true	true	true	true	1,612
1	DISCUSSION	0	null	null	17,403,694	pmid-16878402\|pmid-16601461\|pmid-15688001\|pmid-7923362\|pmid-11023973\|pmid-10646872\|pmid-15951807\|pmid-15706084	In addition, GSNO selectively induced cytosolic translocation of APE1, but not other DNA-repair-related proteins such as XRCC1 (Figure 1B) and thymine DNA glycosylase (data not shown).	null	184	10,088	0	false	null	null	In addition, GSNO selectively induced cytosolic translocation of APE1, but not other DNA-repair-related proteins such as XRCC1 (Figure 1B) and thymine DNA glycosylase (data not shown).	true	true	true	true	true	1,612
1	DISCUSSION	0	null	null	17,403,694	pmid-16878402\|pmid-16601461\|pmid-15688001\|pmid-7923362\|pmid-11023973\|pmid-10646872\|pmid-15951807\|pmid-15706084	It should be pointed out that, although the APE1 nuclear export is specific to NO, the endogenous APE1 appears to show different sensitivities to NO-induced nuclear export among different cell types.	null	199	10,089	0	false	null	null	It should be pointed out that, although the APE1 nuclear export is specific to NO, the endogenous APE1 appears to show different sensitivities to NO-induced nuclear export among different cell types.	true	true	true	true	true	1,612
1	DISCUSSION	0	null	null	17,403,694	pmid-16878402\|pmid-16601461\|pmid-15688001\|pmid-7923362\|pmid-11023973\|pmid-10646872\|pmid-15951807\|pmid-15706084	Of note, the endogenous APE1 in human endothelial cells is strongly refractory to NO-induced nuclear export, although it can still be effectively S-nitrosated under the same circumstances (unpublished data).	null	207	10,090	0	false	null	null	Of note, the endogenous APE1 in human endothelial cells is strongly refractory to NO-induced nuclear export, although it can still be effectively S-nitrosated under the same circumstances (unpublished data).	true	true	true	true	true	1,612
2	DISCUSSION	1	51	[ "B51" ]	17,403,694	pmid-9628873	Although the precise mechanism by which S-nitrosation controls nuclear export of APE1 is not clear, two anti-parallel beta-strands close to Cys93 and Cys310 were found to be critical for the nitrosation-mediated cytosolic translocation of APE1.	[ "51" ]	244	10,091	0	false	Although the precise mechanism by which S-nitrosation controls nuclear export of APE1 is not clear, two anti-parallel beta-strands close to Cys93 and Cys310 were found to be critical for the nitrosation-mediated cytosolic translocation of APE1.	[]	Although the precise mechanism by which S-nitrosation controls nuclear export of APE1 is not clear, two anti-parallel beta-strands close to Cys93 and Cys310 were found to be critical for the nitrosation-mediated cytosolic translocation of APE1.	true	true	true	true	true	1,613
2	DISCUSSION	1	51	[ "B51" ]	17,403,694	pmid-9628873	Previous study revealed that phosphorylation of MK2 can result in intra-molecular de-masking of an NES and, therefore, mediate its nuclear export (51).	[ "51" ]	151	10,092	1	false	Previous study revealed that phosphorylation of MK2 can result in intra-molecular de-masking of an NES and, therefore, mediate its nuclear export.	[ "51" ]	Previous study revealed that phosphorylation of MK2 can result in intra-molecular de-masking of an NES and, therefore, mediate its nuclear export.	true	true	true	true	true	1,613
2	DISCUSSION	1	51	[ "B51" ]	17,403,694	pmid-9628873	Therefore, the conformational change and ‘NES’ exposure of APE1 caused by S-nitrosation modification can be expected in this study.	[ "51" ]	131	10,093	0	false	Therefore, the conformational change and ‘NES’ exposure of APE1 caused by S-nitrosation modification can be expected in this study.	[]	Therefore, the conformational change and ‘NES’ exposure of APE1 caused by S-nitrosation modification can be expected in this study.	true	true	true	true	true	1,613
2	DISCUSSION	1	51	[ "B51" ]	17,403,694	pmid-9628873	We demonstrated that one of the beta-strands (B1) was functional, as the exposure of B1-containing sequence through C-terminal truncation could mediate protein cytosolic localization even in the presence of N-terminal NLS (Figure 5A).	[ "51" ]	234	10,094	0	false	We demonstrated that one of the beta-strands (B1) was functional, as the exposure of B1-containing sequence through C-terminal truncation could mediate protein cytosolic localization even in the presence of N-terminal NLS (Figure 5A).	[]	We demonstrated that one of the beta-strands was functional, as the exposure of B1-containing sequence through C-terminal truncation could mediate protein cytosolic localization even in the presence of N-terminal NLS.	true	true	true	true	true	1,613
2	DISCUSSION	1	51	[ "B51" ]	17,403,694	pmid-9628873	The direct evidence about whether the C-terminal B2 strand is another NO-responsive “NES” has not been proved.	[ "51" ]	110	10,095	0	false	The direct evidence about whether the C-terminal B2 strand is another NO-responsive “NES” has not been proved.	[]	The direct evidence about whether the C-terminal B2 strand is another NO-responsive “NES” has not been proved.	true	true	true	true	true	1,613
2	DISCUSSION	1	51	[ "B51" ]	17,403,694	pmid-9628873	However, either deletion of B2 (Figure 5C) or fusion of GFP to APE1 at the B2 end (unpublished data) strongly repressed NO-stimulated nuclear export, suggesting that a proper conformational change of B2 may contribute to the NO-induced cytosolic translocation of APE1.	[ "51" ]	268	10,096	0	false	However, either deletion of B2 (Figure 5C) or fusion of GFP to APE1 at the B2 end (unpublished data) strongly repressed NO-stimulated nuclear export, suggesting that a proper conformational change of B2 may contribute to the NO-induced cytosolic translocation of APE1.	[]	However, either deletion of B2 or fusion of GFP to APE1 at the B2 end (unpublished data) strongly repressed NO-stimulated nuclear export, suggesting that a proper conformational change of B2 may contribute to the NO-induced cytosolic translocation of APE1.	true	true	true	true	true	1,613
2	DISCUSSION	1	51	[ "B51" ]	17,403,694	pmid-9628873	B1 and B2 may cooperate with each other in mediating APE1 nuclear export.	[ "51" ]	73	10,097	0	false	B1 and B2 may cooperate with each other in mediating APE1 nuclear export.	[]	B1 and B2 may cooperate with each other in mediating APE1 nuclear export.	true	true	true	true	true	1,613
2	DISCUSSION	1	51	[ "B51" ]	17,403,694	pmid-9628873	Alternately, they functioned independently, providing that the inter-strand interaction was disrupted as a result of APE1 S-nitrosation (Figure 8).	[ "51" ]	147	10,098	0	false	Alternately, they functioned independently, providing that the inter-strand interaction was disrupted as a result of APE1 S-nitrosation (Figure 8).	[]	Alternately, they functioned independently, providing that the inter-strand interaction was disrupted as a result of APE1 S-nitrosation (Figure 8).	true	true	true	true	true	1,613
2	DISCUSSION	1	51	[ "B51" ]	17,403,694	pmid-9628873	In addition, it should be emphasized that the nuclear export efficiency of APE1 was high, as a 4-h GSNO treatment almost led to a complete nuclear exclusion of APE1.	[ "51" ]	165	10,099	0	false	In addition, it should be emphasized that the nuclear export efficiency of APE1 was high, as a 4-h GSNO treatment almost led to a complete nuclear exclusion of APE1.	[]	In addition, it should be emphasized that the nuclear export efficiency of APE1 was high, as a 4-h GSNO treatment almost led to a complete nuclear exclusion of APE1.	true	true	true	true	true	1,613

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